Reports of Perceived Adverse Events of Stimulant Medication on Cognition, Motivation, and Mood: Qualitative Investigation and the Generation of Items for the Medication and Cognition Rating Scale.
Identifieur interne : 001A41 ( PubMed/Curation ); précédent : 001A40; suivant : 001A42Reports of Perceived Adverse Events of Stimulant Medication on Cognition, Motivation, and Mood: Qualitative Investigation and the Generation of Items for the Medication and Cognition Rating Scale.
Auteurs : Hanna Kovshoff [Royaume-Uni] ; Tobias Banaschewski [Allemagne] ; Jan K. Buitelaar [Pays-Bas] ; Sara Carucci [Italie] ; David Coghill [Royaume-Uni] ; Marina Danckaerts [Belgique] ; Ralf W. Dittmann [Allemagne] ; Bruno Falissard [France] ; Dina Gojkovic Grimshaw [Royaume-Uni] ; Chris Hollis [Royaume-Uni] ; Sarah Inglis [Royaume-Uni] ; Kerstin Konrad [Allemagne] ; Elizabeth Liddle [Royaume-Uni] ; Suzanne Mccarthy [Irlande (pays)] ; Peter Nagy [Hongrie] ; Margaret Thompson [Royaume-Uni] ; Ian C K. Wong [Royaume-Uni] ; Alessandro Zuddas [Italie] ; Edmund J S. Sonuga-Barke [Royaume-Uni]Source :
- Journal of child and adolescent psychopharmacology [ 1557-8992 ] ; 2016.
Abstract
There is no questionnaire to specifically monitor perceived adverse events of methylphenidate (MPH) on cognition, motivation, and mood. The current study therefore had two goals. First, to harvest accounts of such putative events from transcripts of interviews in samples enriched for such potential experiences. Second, to use the derived data to generate items for a new questionnaire that can be used for monitoring such events in medication trials or routine clinical care.
DOI: 10.1089/cap.2015.0218
PubMed: 27007169
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Reports of Perceived Adverse Events of Stimulant Medication on Cognition, Motivation, and Mood: Qualitative Investigation and the Generation of Items for the Medication and Cognition Rating Scale.</title><author><name sortKey="Kovshoff, Hanna" sort="Kovshoff, Hanna" uniqKey="Kovshoff H" first="Hanna" last="Kovshoff">Hanna Kovshoff</name><affiliation wicri:level="1"><nlm:affiliation>1 Academic Unit of Psychology, University of Southampton , Southampton, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1 Academic Unit of Psychology, University of Southampton , Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Banaschewski, Tobias" sort="Banaschewski, Tobias" uniqKey="Banaschewski T" first="Tobias" last="Banaschewski">Tobias Banaschewski</name><affiliation wicri:level="1"><nlm:affiliation>2 Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg , Mannheim, Germany .</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>2 Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg , Mannheim</wicri:regionArea></affiliation></author><author><name sortKey="Buitelaar, Jan K" sort="Buitelaar, Jan K" uniqKey="Buitelaar J" first="Jan K" last="Buitelaar">Jan K. Buitelaar</name><affiliation wicri:level="1"><nlm:affiliation>3 Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience & Karakter Child and Adolescent Psychiatry University Centre , Nijmegen, the Netherlands .</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>3 Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience & Karakter Child and Adolescent Psychiatry University Centre , Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Carucci, Sara" sort="Carucci, Sara" uniqKey="Carucci S" first="Sara" last="Carucci">Sara Carucci</name><affiliation wicri:level="1"><nlm:affiliation>4 Child and Adolescent Neuropsychiatry Unit, Department of Biomedical Science, University of Cagliari, Italy .</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>4 Child and Adolescent Neuropsychiatry Unit, Department of Biomedical Science, University of Cagliari</wicri:regionArea></affiliation></author><author><name sortKey="Coghill, David" sort="Coghill, David" uniqKey="Coghill D" first="David" last="Coghill">David Coghill</name><affiliation wicri:level="1"><nlm:affiliation>5 Division of Neuroscience, School of Medicine, University of Dundee , Dundee, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>5 Division of Neuroscience, School of Medicine, University of Dundee , Dundee</wicri:regionArea></affiliation></author><author><name sortKey="Danckaerts, Marina" sort="Danckaerts, Marina" uniqKey="Danckaerts M" first="Marina" last="Danckaerts">Marina Danckaerts</name><affiliation wicri:level="1"><nlm:affiliation>7 Department of Neurosciences, Research Group Psychiatry , KU Leuven, Belgium .</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>7 Department of Neurosciences, Research Group Psychiatry , KU Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Dittmann, Ralf W" sort="Dittmann, Ralf W" uniqKey="Dittmann R" first="Ralf W" last="Dittmann">Ralf W. 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Paris</wicri:regionArea></affiliation></author><author><name sortKey="Grimshaw, Dina Gojkovic" sort="Grimshaw, Dina Gojkovic" uniqKey="Grimshaw D" first="Dina Gojkovic" last="Grimshaw">Dina Gojkovic Grimshaw</name><affiliation wicri:level="1"><nlm:affiliation>1 Academic Unit of Psychology, University of Southampton , Southampton, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1 Academic Unit of Psychology, University of Southampton , Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Hollis, Chris" sort="Hollis, Chris" uniqKey="Hollis C" first="Chris" last="Hollis">Chris Hollis</name><affiliation wicri:level="1"><nlm:affiliation>10 Institute of Mental Health, Faculty of Medicine and Health Sciences, University of Nottingham , United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>10 Institute of Mental Health, Faculty of Medicine and Health Sciences, University of Nottingham </wicri:regionArea></affiliation></author><author><name sortKey="Inglis, Sarah" sort="Inglis, Sarah" uniqKey="Inglis S" first="Sarah" last="Inglis">Sarah Inglis</name><affiliation wicri:level="1"><nlm:affiliation>11 Tayside Clinical Trials Unit, University of Dundee , Dundee, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>11 Tayside Clinical Trials Unit, University of Dundee , Dundee</wicri:regionArea></affiliation></author><author><name sortKey="Konrad, Kerstin" sort="Konrad, Kerstin" uniqKey="Konrad K" first="Kerstin" last="Konrad">Kerstin Konrad</name><affiliation wicri:level="1"><nlm:affiliation>12 Clinical Child Neuropsychology, Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital RWTH Aachen , Aachen, Germany .</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>12 Clinical Child Neuropsychology, Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital RWTH Aachen , Aachen</wicri:regionArea></affiliation></author><author><name sortKey="Liddle, Elizabeth" sort="Liddle, Elizabeth" uniqKey="Liddle E" first="Elizabeth" last="Liddle">Elizabeth Liddle</name><affiliation wicri:level="1"><nlm:affiliation>10 Institute of Mental Health, Faculty of Medicine and Health Sciences, University of Nottingham , United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>10 Institute of Mental Health, Faculty of Medicine and Health Sciences, University of Nottingham </wicri:regionArea></affiliation></author><author><name sortKey="Mccarthy, Suzanne" sort="Mccarthy, Suzanne" uniqKey="Mccarthy S" first="Suzanne" last="Mccarthy">Suzanne Mccarthy</name><affiliation wicri:level="1"><nlm:affiliation>14 School of Pharmacy, University College Cork , Cork, Ireland .</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>14 School of Pharmacy, University College Cork , Cork</wicri:regionArea></affiliation></author><author><name sortKey="Nagy, Peter" sort="Nagy, Peter" uniqKey="Nagy P" first="Peter" last="Nagy">Peter Nagy</name><affiliation wicri:level="1"><nlm:affiliation>15 Vadaskert Child and Adolescent Psychiatric Hospital , Budapest, Hungary .</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>15 Vadaskert Child and Adolescent Psychiatric Hospital , Budapest</wicri:regionArea></affiliation></author><author><name sortKey="Thompson, Margaret" sort="Thompson, Margaret" uniqKey="Thompson M" first="Margaret" last="Thompson">Margaret Thompson</name><affiliation wicri:level="1"><nlm:affiliation>1 Academic Unit of Psychology, University of Southampton , Southampton, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1 Academic Unit of Psychology, University of Southampton , Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Ian C K" sort="Wong, Ian C K" uniqKey="Wong I" first="Ian C K" last="Wong">Ian C K. Wong</name><affiliation wicri:level="1"><nlm:affiliation>16 UCL School of Pharmacy , London, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>16 UCL School of Pharmacy , London</wicri:regionArea></affiliation></author><author><name sortKey="Zuddas, Alessandro" sort="Zuddas, Alessandro" uniqKey="Zuddas A" first="Alessandro" last="Zuddas">Alessandro Zuddas</name><affiliation wicri:level="1"><nlm:affiliation>4 Child and Adolescent Neuropsychiatry Unit, Department of Biomedical Science, University of Cagliari, Italy .</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>4 Child and Adolescent Neuropsychiatry Unit, Department of Biomedical Science, University of Cagliari</wicri:regionArea></affiliation></author><author><name sortKey="Sonuga Barke, Edmund J S" sort="Sonuga Barke, Edmund J S" uniqKey="Sonuga Barke E" first="Edmund J S" last="Sonuga-Barke">Edmund J S. Sonuga-Barke</name><affiliation wicri:level="1"><nlm:affiliation>1 Academic Unit of Psychology, University of Southampton , Southampton, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1 Academic Unit of Psychology, University of Southampton , Southampton</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27007169</idno><idno type="pmid">27007169</idno><idno type="doi">10.1089/cap.2015.0218</idno><idno type="wicri:Area/PubMed/Corpus">001A65</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001A65</idno><idno type="wicri:Area/PubMed/Curation">001A41</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001A41</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Reports of Perceived Adverse Events of Stimulant Medication on Cognition, Motivation, and Mood: Qualitative Investigation and the Generation of Items for the Medication and Cognition Rating Scale.</title><author><name sortKey="Kovshoff, Hanna" sort="Kovshoff, Hanna" uniqKey="Kovshoff H" first="Hanna" last="Kovshoff">Hanna Kovshoff</name><affiliation wicri:level="1"><nlm:affiliation>1 Academic Unit of Psychology, University of Southampton , Southampton, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1 Academic Unit of Psychology, University of Southampton , Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Banaschewski, Tobias" sort="Banaschewski, Tobias" uniqKey="Banaschewski T" first="Tobias" last="Banaschewski">Tobias Banaschewski</name><affiliation wicri:level="1"><nlm:affiliation>2 Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg , Mannheim, Germany .</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>2 Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg , Mannheim</wicri:regionArea></affiliation></author><author><name sortKey="Buitelaar, Jan K" sort="Buitelaar, Jan K" uniqKey="Buitelaar J" first="Jan K" last="Buitelaar">Jan K. Buitelaar</name><affiliation wicri:level="1"><nlm:affiliation>3 Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience & Karakter Child and Adolescent Psychiatry University Centre , Nijmegen, the Netherlands .</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>3 Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience & Karakter Child and Adolescent Psychiatry University Centre , Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Carucci, Sara" sort="Carucci, Sara" uniqKey="Carucci S" first="Sara" last="Carucci">Sara Carucci</name><affiliation wicri:level="1"><nlm:affiliation>4 Child and Adolescent Neuropsychiatry Unit, Department of Biomedical Science, University of Cagliari, Italy .</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>4 Child and Adolescent Neuropsychiatry Unit, Department of Biomedical Science, University of Cagliari</wicri:regionArea></affiliation></author><author><name sortKey="Coghill, David" sort="Coghill, David" uniqKey="Coghill D" first="David" last="Coghill">David Coghill</name><affiliation wicri:level="1"><nlm:affiliation>5 Division of Neuroscience, School of Medicine, University of Dundee , Dundee, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>5 Division of Neuroscience, School of Medicine, University of Dundee , Dundee</wicri:regionArea></affiliation></author><author><name sortKey="Danckaerts, Marina" sort="Danckaerts, Marina" uniqKey="Danckaerts M" first="Marina" last="Danckaerts">Marina Danckaerts</name><affiliation wicri:level="1"><nlm:affiliation>7 Department of Neurosciences, Research Group Psychiatry , KU Leuven, Belgium .</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>7 Department of Neurosciences, Research Group Psychiatry , KU Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Dittmann, Ralf W" sort="Dittmann, Ralf W" uniqKey="Dittmann R" first="Ralf W" last="Dittmann">Ralf W. Dittmann</name><affiliation wicri:level="1"><nlm:affiliation>8 Paediatric Psychopharmacology, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg , Germany .</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>8 Paediatric Psychopharmacology, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg </wicri:regionArea></affiliation></author><author><name sortKey="Falissard, Bruno" sort="Falissard, Bruno" uniqKey="Falissard B" first="Bruno" last="Falissard">Bruno Falissard</name><affiliation wicri:level="1"><nlm:affiliation>9 INSERM U1178, University Paris-Sud, University Paris-Descartes , AP-HP, Paris, France .</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>9 INSERM U1178, University Paris-Sud, University Paris-Descartes , AP-HP, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Grimshaw, Dina Gojkovic" sort="Grimshaw, Dina Gojkovic" uniqKey="Grimshaw D" first="Dina Gojkovic" last="Grimshaw">Dina Gojkovic Grimshaw</name><affiliation wicri:level="1"><nlm:affiliation>1 Academic Unit of Psychology, University of Southampton , Southampton, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1 Academic Unit of Psychology, University of Southampton , Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Hollis, Chris" sort="Hollis, Chris" uniqKey="Hollis C" first="Chris" last="Hollis">Chris Hollis</name><affiliation wicri:level="1"><nlm:affiliation>10 Institute of Mental Health, Faculty of Medicine and Health Sciences, University of Nottingham , United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>10 Institute of Mental Health, Faculty of Medicine and Health Sciences, University of Nottingham </wicri:regionArea></affiliation></author><author><name sortKey="Inglis, Sarah" sort="Inglis, Sarah" uniqKey="Inglis S" first="Sarah" last="Inglis">Sarah Inglis</name><affiliation wicri:level="1"><nlm:affiliation>11 Tayside Clinical Trials Unit, University of Dundee , Dundee, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>11 Tayside Clinical Trials Unit, University of Dundee , Dundee</wicri:regionArea></affiliation></author><author><name sortKey="Konrad, Kerstin" sort="Konrad, Kerstin" uniqKey="Konrad K" first="Kerstin" last="Konrad">Kerstin Konrad</name><affiliation wicri:level="1"><nlm:affiliation>12 Clinical Child Neuropsychology, Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital RWTH Aachen , Aachen, Germany .</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>12 Clinical Child Neuropsychology, Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital RWTH Aachen , Aachen</wicri:regionArea></affiliation></author><author><name sortKey="Liddle, Elizabeth" sort="Liddle, Elizabeth" uniqKey="Liddle E" first="Elizabeth" last="Liddle">Elizabeth Liddle</name><affiliation wicri:level="1"><nlm:affiliation>10 Institute of Mental Health, Faculty of Medicine and Health Sciences, University of Nottingham , United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>10 Institute of Mental Health, Faculty of Medicine and Health Sciences, University of Nottingham </wicri:regionArea></affiliation></author><author><name sortKey="Mccarthy, Suzanne" sort="Mccarthy, Suzanne" uniqKey="Mccarthy S" first="Suzanne" last="Mccarthy">Suzanne Mccarthy</name><affiliation wicri:level="1"><nlm:affiliation>14 School of Pharmacy, University College Cork , Cork, Ireland .</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>14 School of Pharmacy, University College Cork , Cork</wicri:regionArea></affiliation></author><author><name sortKey="Nagy, Peter" sort="Nagy, Peter" uniqKey="Nagy P" first="Peter" last="Nagy">Peter Nagy</name><affiliation wicri:level="1"><nlm:affiliation>15 Vadaskert Child and Adolescent Psychiatric Hospital , Budapest, Hungary .</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>15 Vadaskert Child and Adolescent Psychiatric Hospital , Budapest</wicri:regionArea></affiliation></author><author><name sortKey="Thompson, Margaret" sort="Thompson, Margaret" uniqKey="Thompson M" first="Margaret" last="Thompson">Margaret Thompson</name><affiliation wicri:level="1"><nlm:affiliation>1 Academic Unit of Psychology, University of Southampton , Southampton, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1 Academic Unit of Psychology, University of Southampton , Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Ian C K" sort="Wong, Ian C K" uniqKey="Wong I" first="Ian C K" last="Wong">Ian C K. Wong</name><affiliation wicri:level="1"><nlm:affiliation>16 UCL School of Pharmacy , London, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>16 UCL School of Pharmacy , London</wicri:regionArea></affiliation></author><author><name sortKey="Zuddas, Alessandro" sort="Zuddas, Alessandro" uniqKey="Zuddas A" first="Alessandro" last="Zuddas">Alessandro Zuddas</name><affiliation wicri:level="1"><nlm:affiliation>4 Child and Adolescent Neuropsychiatry Unit, Department of Biomedical Science, University of Cagliari, Italy .</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>4 Child and Adolescent Neuropsychiatry Unit, Department of Biomedical Science, University of Cagliari</wicri:regionArea></affiliation></author><author><name sortKey="Sonuga Barke, Edmund J S" sort="Sonuga Barke, Edmund J S" uniqKey="Sonuga Barke E" first="Edmund J S" last="Sonuga-Barke">Edmund J S. Sonuga-Barke</name><affiliation wicri:level="1"><nlm:affiliation>1 Academic Unit of Psychology, University of Southampton , Southampton, United Kingdom .</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1 Academic Unit of Psychology, University of Southampton , Southampton</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of child and adolescent psychopharmacology</title><idno type="eISSN">1557-8992</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is no questionnaire to specifically monitor perceived adverse events of methylphenidate (MPH) on cognition, motivation, and mood. The current study therefore had two goals. First, to harvest accounts of such putative events from transcripts of interviews in samples enriched for such potential experiences. Second, to use the derived data to generate items for a new questionnaire that can be used for monitoring such events in medication trials or routine clinical care.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27007169</PMID><DateCreated><Year>2016</Year><Month>08</Month><Day>20</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1557-8992</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>6</Issue><PubDate><Year>2016</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Journal of child and adolescent psychopharmacology</Title><ISOAbbreviation>J Child Adolesc Psychopharmacol</ISOAbbreviation></Journal><ArticleTitle>Reports of Perceived Adverse Events of Stimulant Medication on Cognition, Motivation, and Mood: Qualitative Investigation and the Generation of Items for the Medication and Cognition Rating Scale.</ArticleTitle><Pagination><MedlinePgn>537-47</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1089/cap.2015.0218</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">There is no questionnaire to specifically monitor perceived adverse events of methylphenidate (MPH) on cognition, motivation, and mood. The current study therefore had two goals. First, to harvest accounts of such putative events from transcripts of interviews in samples enriched for such potential experiences. Second, to use the derived data to generate items for a new questionnaire that can be used for monitoring such events in medication trials or routine clinical care.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Following a literature search aimed at identifying associations between MPH and cognition and/or motivation, a qualitative semistructured interview was designed to focus specifically on the domains of cognition (i.e., reasoning, depth/breadth of thinking, intellectual capacity, and creativity) and motivation (i.e., drive, effort, and attitudes toward rewards/incentives). Interviews were conducted with 45 participants drawn from the following four groups: (a) clinicians, child and adolescent psychiatrists, and pediatricians specializing in attention-deficit/hyperactivity disorder (ADHD) (n = 15); (2) teachers, with experience of teaching at least 10 medicated children with ADHD (n = 10); (3) parents of children with ADHD (n = 8) treated with MPH; and (4) adolescents/adults with ADHD (n = 12). Purposeful sampling was used to selectively recruit ADHD participants whose histories suggested a degree of vulnerability to MPH adverse events. Data were analyzed using a deductive approach to content analysis.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">While we probed purposefully for cognitive and motivational adverse events, a third domain, related to mood, emerged from the reports. Therefore, three domains, each with a number of subdomains, were identified from the interview accounts: (i) Cognition (six subdomains; attention/concentration, changes in thinking, reduced creativity, sensory overload, memory, slower processing speed); (ii) motivation (four subdomains; loss of intrinsic motivation for goal-directed activities, external locus of control, lack of effort/engagement in daily tasks, increased focus on incentives); and (iii) mood (three subdomains; dampening of spontaneity/flat affect, mood dysregulation, increased anxiety/edginess). On the basis of these reports, 34 items were specified and incorporated into a prototype questionnaire, which was piloted and refined on the basis of field-testing.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Items were identified that capture potential/perceived cognitive, motivational, and mood-related adverse events of MPH. The items generated will allow us to further develop and psychometrically examine their prevalence, and the extent to which they are associated with medication adherence, treatment outcome, impairment, and other reported adverse events (e.g., loss of appetite/cardiovascular effects).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kovshoff</LastName><ForeName>Hanna</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>1 Academic Unit of Psychology, University of Southampton , Southampton, United Kingdom .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Banaschewski</LastName><ForeName>Tobias</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>2 Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg , Mannheim, Germany .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buitelaar</LastName><ForeName>Jan K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>3 Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience & Karakter Child and Adolescent Psychiatry University Centre , Nijmegen, the Netherlands .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carucci</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>4 Child and Adolescent Neuropsychiatry Unit, Department of Biomedical Science, University of Cagliari, Italy .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coghill</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>5 Division of Neuroscience, School of Medicine, University of Dundee , Dundee, United Kingdom .</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>6 Departments of Paediatrics and Psychiatry, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne , Australia .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Danckaerts</LastName><ForeName>Marina</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>7 Department of Neurosciences, Research Group Psychiatry , KU Leuven, Belgium .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dittmann</LastName><ForeName>Ralf W</ForeName><Initials>RW</Initials><AffiliationInfo><Affiliation>8 Paediatric Psychopharmacology, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg , Germany .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Falissard</LastName><ForeName>Bruno</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>9 INSERM U1178, University Paris-Sud, University Paris-Descartes , AP-HP, Paris, France .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grimshaw</LastName><ForeName>Dina Gojkovic</ForeName><Initials>DG</Initials><AffiliationInfo><Affiliation>1 Academic Unit of Psychology, University of Southampton , Southampton, United Kingdom .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hollis</LastName><ForeName>Chris</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>10 Institute of Mental Health, Faculty of Medicine and Health Sciences, University of Nottingham , United Kingdom .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Inglis</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>11 Tayside Clinical Trials Unit, University of Dundee , Dundee, United Kingdom .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Konrad</LastName><ForeName>Kerstin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>12 Clinical Child Neuropsychology, Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital RWTH Aachen , Aachen, Germany .</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>13 Institute of Neuroscience & Medicine (INM3), Research Centre Juelich, Germany .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liddle</LastName><ForeName>Elizabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>10 Institute of Mental Health, Faculty of Medicine and Health Sciences, University of Nottingham , United Kingdom .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCarthy</LastName><ForeName>Suzanne</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>14 School of Pharmacy, University College Cork , Cork, Ireland .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nagy</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>15 Vadaskert Child and Adolescent Psychiatric Hospital , Budapest, Hungary .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thompson</LastName><ForeName>Margaret</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>1 Academic Unit of Psychology, University of Southampton , Southampton, United Kingdom .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Ian C K</ForeName><Initials>IC</Initials><AffiliationInfo><Affiliation>16 UCL School of Pharmacy , London, United Kingdom .</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>17 Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine University of Hong Kong , China .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zuddas</LastName><ForeName>Alessandro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>4 Child and Adolescent Neuropsychiatry Unit, Department of Biomedical Science, University of Cagliari, Italy .</Affiliation></AffiliationInfo></Author><Author 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