X-Tream quality assurance in synchrotron X-ray microbeam radiation therapy.
Identifieur interne : 001933 ( PubMed/Curation ); précédent : 001932; suivant : 001934X-Tream quality assurance in synchrotron X-ray microbeam radiation therapy.
Auteurs : Pauline Fournier [Australie] ; Iwan Cornelius [Australie] ; Mattia Donzelli [France] ; Herwig Requardt [France] ; Christian Nemoz [France] ; Marco Petasecca [Australie] ; Elke Br Uer-Krisch [France] ; Anatoly Rosenfeld [Australie] ; Michael Lerch [Australie]Source :
- Journal of synchrotron radiation [ 1600-5775 ] ; 2016.
Abstract
Microbeam radiation therapy (MRT) is a novel irradiation technique for brain tumours treatment currently under development at the European Synchrotron Radiation Facility in Grenoble, France. The technique is based on the spatial fractionation of a highly brilliant synchrotron X-ray beam into an array of microbeams using a multi-slit collimator (MSC). After promising pre-clinical results, veterinary trials have recently commenced requiring the need for dedicated quality assurance (QA) procedures. The quality of MRT treatment demands reproducible and precise spatial fractionation of the incoming synchrotron beam. The intensity profile of the microbeams must also be quickly and quantitatively characterized prior to each treatment for comparison with that used for input to the dose-planning calculations. The Centre for Medical Radiation Physics (University of Wollongong, Australia) has developed an X-ray treatment monitoring system (X-Tream) which incorporates a high-spatial-resolution silicon strip detector (SSD) specifically designed for MRT. In-air measurements of the horizontal profile of the intrinsic microbeam X-ray field in order to determine the relative intensity of each microbeam are presented, and the alignment of the MSC is also assessed. The results show that the SSD is able to resolve individual microbeams which therefore provides invaluable QA of the horizontal field size and microbeam number and shape. They also demonstrate that the SSD used in the X-Tream system is very sensitive to any small misalignment of the MSC. In order to allow as rapid QA as possible, a fast alignment procedure of the SSD based on X-ray imaging with a low-intensity low-energy beam has been developed and is presented in this publication.
DOI: 10.1107/S1600577516009322
PubMed: 27577773
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Facility</wicri:regionArea></affiliation></author><author><name sortKey="Requardt, Herwig" sort="Requardt, Herwig" uniqKey="Requardt H" first="Herwig" last="Requardt">Herwig Requardt</name><affiliation wicri:level="1"><nlm:affiliation>European Synchrotron Radiation Facility, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>European Synchrotron Radiation Facility</wicri:regionArea></affiliation></author><author><name sortKey="Nemoz, Christian" sort="Nemoz, Christian" uniqKey="Nemoz C" first="Christian" last="Nemoz">Christian Nemoz</name><affiliation wicri:level="1"><nlm:affiliation>European Synchrotron Radiation Facility, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>European Synchrotron Radiation Facility</wicri:regionArea></affiliation></author><author><name sortKey="Petasecca, Marco" sort="Petasecca, Marco" uniqKey="Petasecca M" first="Marco" last="Petasecca">Marco Petasecca</name><affiliation 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xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong</wicri:regionArea></affiliation></author><author><name sortKey="Lerch, Michael" sort="Lerch, Michael" uniqKey="Lerch M" first="Michael" last="Lerch">Michael Lerch</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics, University of Wollongong, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of synchrotron radiation</title><idno type="eISSN">1600-5775</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Microbeam radiation therapy (MRT) is a novel irradiation technique for brain tumours treatment currently under development at the European Synchrotron Radiation Facility in Grenoble, France. The technique is based on the spatial fractionation of a highly brilliant synchrotron X-ray beam into an array of microbeams using a multi-slit collimator (MSC). After promising pre-clinical results, veterinary trials have recently commenced requiring the need for dedicated quality assurance (QA) procedures. The quality of MRT treatment demands reproducible and precise spatial fractionation of the incoming synchrotron beam. The intensity profile of the microbeams must also be quickly and quantitatively characterized prior to each treatment for comparison with that used for input to the dose-planning calculations. The Centre for Medical Radiation Physics (University of Wollongong, Australia) has developed an X-ray treatment monitoring system (X-Tream) which incorporates a high-spatial-resolution silicon strip detector (SSD) specifically designed for MRT. In-air measurements of the horizontal profile of the intrinsic microbeam X-ray field in order to determine the relative intensity of each microbeam are presented, and the alignment of the MSC is also assessed. The results show that the SSD is able to resolve individual microbeams which therefore provides invaluable QA of the horizontal field size and microbeam number and shape. They also demonstrate that the SSD used in the X-Tream system is very sensitive to any small misalignment of the MSC. In order to allow as rapid QA as possible, a fast alignment procedure of the SSD based on X-ray imaging with a low-intensity low-energy beam has been developed and is presented in this publication.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">27577773</PMID><DateCreated><Year>2016</Year><Month>08</Month><Day>31</Day></DateCreated><DateRevised><Year>2016</Year><Month>08</Month><Day>31</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-5775</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>Pt 5</Issue><PubDate><Year>2016</Year><Month>Sep</Month><Day>01</Day></PubDate></JournalIssue><Title>Journal of synchrotron radiation</Title><ISOAbbreviation>J Synchrotron Radiat</ISOAbbreviation></Journal><ArticleTitle>X-Tream quality assurance in synchrotron X-ray microbeam radiation therapy.</ArticleTitle><Pagination><MedlinePgn>1180-90</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1107/S1600577516009322</ELocationID><Abstract><AbstractText>Microbeam radiation therapy (MRT) is a novel irradiation technique for brain tumours treatment currently under development at the European Synchrotron Radiation Facility in Grenoble, France. The technique is based on the spatial fractionation of a highly brilliant synchrotron X-ray beam into an array of microbeams using a multi-slit collimator (MSC). After promising pre-clinical results, veterinary trials have recently commenced requiring the need for dedicated quality assurance (QA) procedures. The quality of MRT treatment demands reproducible and precise spatial fractionation of the incoming synchrotron beam. The intensity profile of the microbeams must also be quickly and quantitatively characterized prior to each treatment for comparison with that used for input to the dose-planning calculations. The Centre for Medical Radiation Physics (University of Wollongong, Australia) has developed an X-ray treatment monitoring system (X-Tream) which incorporates a high-spatial-resolution silicon strip detector (SSD) specifically designed for MRT. In-air measurements of the horizontal profile of the intrinsic microbeam X-ray field in order to determine the relative intensity of each microbeam are presented, and the alignment of the MSC is also assessed. The results show that the SSD is able to resolve individual microbeams which therefore provides invaluable QA of the horizontal field size and microbeam number and shape. They also demonstrate that the SSD used in the X-Tream system is very sensitive to any small misalignment of the MSC. In order to allow as rapid QA as possible, a fast alignment procedure of the SSD based on X-ray imaging with a low-intensity low-energy beam has been developed and is presented in this publication.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fournier</LastName><ForeName>Pauline</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Centre for Medical Radiation Physics, University of Wollongong, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cornelius</LastName><ForeName>Iwan</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Centre for Medical Radiation Physics, University of Wollongong, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Donzelli</LastName><ForeName>Mattia</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>European Synchrotron Radiation Facility, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Requardt</LastName><ForeName>Herwig</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>European Synchrotron Radiation Facility, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nemoz</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>European Synchrotron Radiation Facility, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petasecca</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre for Medical Radiation Physics, University of Wollongong, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bräuer-Krisch</LastName><ForeName>Elke</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>European Synchrotron Radiation Facility, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosenfeld</LastName><ForeName>Anatoly</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre for Medical Radiation Physics, University of Wollongong, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lerch</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre for Medical Radiation Physics, University of Wollongong, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>07</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Synchrotron Radiat</MedlineTA><NlmUniqueID>9888878</NlmUniqueID><ISSNLinking>0909-0495</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">high resolution detector</Keyword><Keyword MajorTopicYN="N">microbeam radiation therapy</Keyword><Keyword MajorTopicYN="N">quality assurance</Keyword><Keyword MajorTopicYN="N">silicon single strip detector</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>03</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>06</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>9</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>9</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>9</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27577773</ArticleId><ArticleId IdType="pii">S1600577516009322</ArticleId><ArticleId IdType="doi">10.1107/S1600577516009322</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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