Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21.
Identifieur interne : 001719 ( PubMed/Curation ); précédent : 001718; suivant : 001720Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21.
Auteurs : Mingfeng Zhang [États-Unis] ; Zhaoming Wang [États-Unis] ; Ofure Obazee [Allemagne] ; Jinping Jia [États-Unis] ; Erica J. Childs [États-Unis] ; Jason Hoskins [États-Unis] ; Gisella Figlioli [Allemagne] ; Evelina Mocci [États-Unis] ; Irene Collins [États-Unis] ; Charles C. Chung [États-Unis] ; Christopher Hautman [États-Unis] ; Alan A. Arslan [États-Unis] ; Laura Beane-Freeman [États-Unis] ; Paige M. Bracci [États-Unis] ; Julie Buring [États-Unis] ; Eric J. Duell [Espagne] ; Steven Gallinger [Canada] ; Graham G. Giles [Australie] ; Gary E. Goodman [États-Unis] ; Phyllis J. Goodman [États-Unis] ; Aruna Kamineni [États-Unis] ; Laurence N. Kolonel [États-Unis] ; Matthew H. Kulke [États-Unis] ; Núria Malats [Espagne] ; Sara H. Olson [États-Unis] ; Howard D. Sesso [États-Unis] ; Kala Visvanathan [États-Unis] ; Emily White [États-Unis] ; Wei Zheng [États-Unis] ; Christian C. Abnet [États-Unis] ; Demetrius Albanes [États-Unis] ; Gabriella Andreotti [États-Unis] ; Lauren Brais [États-Unis] ; H Bas Bueno-De-Mesquita [Pays-Bas] ; Daniela Basso [Pays-Bas] ; Sonja I. Berndt [États-Unis] ; Marie-Christine Boutron-Ruault [France] ; Maarten F. Bijlsma [Pays-Bas] ; Hermann Brenner [Allemagne] ; Laurie Burdette [États-Unis] ; Daniele Campa [Italie] ; Neil E. Caporaso [États-Unis] ; Gabriele Capurso [Italie] ; Giulia Martina Cavestro [Italie] ; Michelle Cotterchio [Canada] ; Eithne Costello [Royaume-Uni] ; Joanne Elena [États-Unis] ; Ugo Boggi [Italie] ; J Michael Gaziano [États-Unis] ; Maria Gazouli [Grèce] ; Edward L. Giovannucci [États-Unis] ; Michael Goggins [États-Unis] ; Myron Gross [États-Unis] ; Christopher A. Haiman [États-Unis] ; Manal Hassan [États-Unis] ; Kathy J. Helzlsouer [États-Unis] ; Nan Hu [États-Unis] ; David J. Hunter [États-Unis] ; Elzbieta Iskierka-Jazdzewska [Pologne] ; Mazda Jenab [France] ; Rudolf Kaaks [Allemagne] ; Timothy J. Key [Royaume-Uni] ; Kay-Tee Khaw [Royaume-Uni] ; Eric A. Klein [États-Unis] ; Manolis Kogevinas [Espagne] ; Vittorio Krogh [Italie] ; Juozas Kupcinskas [Lituanie] ; Robert C. Kurtz [États-Unis] ; Maria T. Landi [États-Unis] ; Stefano Landi [Italie] ; Loic Le Marchand [États-Unis] ; Andrea Mambrini [Italie] ; Satu Mannisto [Finlande] ; Roger L. Milne [Australie] ; Rachel E. Neale [Australie] ; Ann L. Oberg [États-Unis] ; Salvatore Panico [Italie] ; Alpa V. Patel [États-Unis] ; Petra H M. Peeters [Pays-Bas] ; Ulrike Peters [États-Unis] ; Raffaele Pezzilli [Italie] ; Miquel Porta [Espagne] ; Mark Purdue [États-Unis] ; J Ram N Quiros [Espagne] ; Elio Riboli [Royaume-Uni] ; Nathaniel Rothman [États-Unis] ; Aldo Scarpa [Italie] ; Ghislaine Scelo [France] ; Xiao-Ou Shu [États-Unis] ; Debra T. Silverman [États-Unis] ; Pavel Soucek [République tchèque] ; Oliver Strobel [Allemagne] ; Malin Sund [Suède] ; Ewa Małecka-Panas [Pologne] ; Philip R. Taylor [États-Unis] ; Francesca Tavano [Italie] ; Ruth C. Travis [Royaume-Uni] ; Mark Thornquist [États-Unis] ; Anne Tj Nneland [Danemark] ; Geoffrey S. Tobias [États-Unis] ; Dimitrios Trichopoulos [États-Unis] ; Yogesh Vashist [Allemagne] ; Pavel Vodicka [République tchèque] ; Jean Wactawski-Wende [États-Unis] ; Nicolas Wentzensen [États-Unis] ; Herbert Yu [États-Unis] ; Kai Yu [États-Unis] ; Anne Zeleniuch-Jacquotte [États-Unis] ; Charles Kooperberg [États-Unis] ; Harvey A. Risch [États-Unis] ; Eric J. Jacobs [États-Unis] ; Donghui Li [États-Unis] ; Charles Fuchs [États-Unis] ; Robert Hoover [États-Unis] ; Patricia Hartge [États-Unis] ; Stephen J. Chanock [États-Unis] ; Gloria M. Petersen [États-Unis] ; Rachael S. Stolzenberg-Solomon [États-Unis] ; Brian M. Wolpin [États-Unis] ; Peter Kraft [États-Unis] ; Alison P. Klein [États-Unis] ; Federico Canzian [Allemagne] ; Laufey T. Amundadottir [États-Unis]Source :
- Oncotarget [ 1949-2553 ] ; 2016.
Abstract
Genome-wide association studies (GWAS) have identified common pancreatic cancer susceptibility variants at 13 chromosomal loci in individuals of European descent. To identify new susceptibility variants, we performed imputation based on 1000 Genomes (1000G) Project data and association analysis using 5,107 case and 8,845 control subjects from 27 cohort and case-control studies that participated in the PanScan I-III GWAS. This analysis, in combination with a two-staged replication in an additional 6,076 case and 7,555 control subjects from the PANcreatic Disease ReseArch (PANDoRA) and Pancreatic Cancer Case-Control (PanC4) Consortia uncovered 3 new pancreatic cancer risk signals marked by single nucleotide polymorphisms (SNPs) rs2816938 at chromosome 1q32.1 (per allele odds ratio (OR) = 1.20, P = 4.88x10 -15), rs10094872 at 8q24.21 (OR = 1.15, P = 3.22x10 -9) and rs35226131 at 5p15.33 (OR = 0.71, P = 1.70x10 -8). These SNPs represent independent risk variants at previously identified pancreatic cancer risk loci on chr1q32.1 ( NR5A2), chr8q24.21 ( MYC) and chr5p15.33 ( CLPTM1L- TERT) as per analyses conditioned on previously reported susceptibility variants. We assessed expression of candidate genes at the three risk loci in histologically normal ( n = 10) and tumor ( n = 8) derived pancreatic tissue samples and observed a marked reduction of NR5A2 expression (chr1q32.1) in the tumors (fold change -7.6, P = 5.7x10 -8). This finding was validated in a second set of paired ( n = 20) histologically normal and tumor derived pancreatic tissue samples (average fold change for three NR5A2 isoforms -31.3 to -95.7, P = 7.5x10 -4-2.0x10 -3). Our study has identified new susceptibility variants independently conferring pancreatic cancer risk that merit functional follow-up to identify target genes and explain the underlying biology.
DOI: 10.18632/oncotarget.11041
PubMed: 27579533
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Goodman</name><affiliation wicri:level="1"><nlm:affiliation>Southwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Southwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Kamineni, Aruna" sort="Kamineni, Aruna" uniqKey="Kamineni A" first="Aruna" last="Kamineni">Aruna Kamineni</name><affiliation wicri:level="1"><nlm:affiliation>Group Health Research Institute, Seattle, Washington, USA,.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute, Seattle, Washington, USA</wicri:regionArea></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N" last="Kolonel">Laurence N. Kolonel</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</wicri:regionArea></affiliation></author><author><name sortKey="Kulke, Matthew H" sort="Kulke, Matthew H" uniqKey="Kulke M" first="Matthew H" last="Kulke">Matthew H. Kulke</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Malats, Nuria" sort="Malats, Nuria" uniqKey="Malats N" first="Núria" last="Malats">Núria Malats</name><affiliation wicri:level="1"><nlm:affiliation>Genetic and Molecular Epidemiology Group, CNIO-Spanish National Cancer Research Centre, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, CNIO-Spanish National Cancer Research Centre, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Olson, Sara H" sort="Olson, Sara H" uniqKey="Olson S" first="Sara H" last="Olson">Sara H. Olson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Sesso, Howard D" sort="Sesso, Howard D" uniqKey="Sesso H" first="Howard D" last="Sesso">Howard D. Sesso</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Visvanathan, Kala" sort="Visvanathan, Kala" uniqKey="Visvanathan K" first="Kala" last="Visvanathan">Kala Visvanathan</name><affiliation wicri:level="1"><nlm:affiliation>Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation wicri:level="1"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Abnet, Christian C" sort="Abnet, Christian C" uniqKey="Abnet C" first="Christian C" last="Abnet">Christian C. Abnet</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Andreotti, Gabriella" sort="Andreotti, Gabriella" uniqKey="Andreotti G" first="Gabriella" last="Andreotti">Gabriella Andreotti</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Brais, Lauren" sort="Brais, Lauren" uniqKey="Brais L" first="Lauren" last="Brais">Lauren Brais</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name><affiliation wicri:level="1"><nlm:affiliation>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea></affiliation></author><author><name sortKey="Basso, Daniela" sort="Basso, Daniela" uniqKey="Basso D" first="Daniela" last="Basso">Daniela Basso</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, University Hospital of Padova, Padua, Italy,.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Laboratory Medicine, University Hospital of Padova, Padua, Italy</wicri:regionArea></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation wicri:level="1"><nlm:affiliation>Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health Team, F-94805, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health Team, F-94805, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Bijlsma, Maarten F" sort="Bijlsma, Maarten F" uniqKey="Bijlsma M" first="Maarten F" last="Bijlsma">Maarten F. Bijlsma</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory for Experimental Oncology and Radiobiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Laboratory for Experimental Oncology and Radiobiology, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Burdette, Laurie" sort="Burdette, Laurie" uniqKey="Burdette L" first="Laurie" last="Burdette">Laurie Burdette</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Campa, Daniele" sort="Campa, Daniele" uniqKey="Campa D" first="Daniele" last="Campa">Daniele Campa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, University of Pisa, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Pisa, Pisa</wicri:regionArea></affiliation></author><author><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E" last="Caporaso">Neil E. Caporaso</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Capurso, Gabriele" sort="Capurso, Gabriele" uniqKey="Capurso G" first="Gabriele" last="Capurso">Gabriele Capurso</name><affiliation wicri:level="1"><nlm:affiliation>Digestive and Liver Disease Unit, 'Sapienza' University of Rome, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Digestive and Liver Disease Unit, 'Sapienza' University of Rome, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Cavestro, Giulia Martina" sort="Cavestro, Giulia Martina" uniqKey="Cavestro G" first="Giulia Martina" last="Cavestro">Giulia Martina Cavestro</name><affiliation wicri:level="1"><nlm:affiliation>Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Cotterchio, Michelle" sort="Cotterchio, Michelle" uniqKey="Cotterchio M" first="Michelle" last="Cotterchio">Michelle Cotterchio</name><affiliation wicri:level="1"><nlm:affiliation>Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Costello, Eithne" sort="Costello, Eithne" uniqKey="Costello E" first="Eithne" last="Costello">Eithne Costello</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool</wicri:regionArea></affiliation></author><author><name sortKey="Elena, Joanne" sort="Elena, Joanne" uniqKey="Elena J" first="Joanne" last="Elena">Joanne Elena</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Boggi, Ugo" sort="Boggi, Ugo" uniqKey="Boggi U" first="Ugo" last="Boggi">Ugo Boggi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Unit of Experimental Surgical Pathology, University Hospital of Pisa, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Surgery, Unit of Experimental Surgical Pathology, University Hospital of Pisa, Pisa</wicri:regionArea></affiliation></author><author><name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J Michael" last="Gaziano">J Michael Gaziano</name><affiliation wicri:level="1"><nlm:affiliation>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Gazouli, Maria" sort="Gazouli, Maria" uniqKey="Gazouli M" first="Maria" last="Gazouli">Maria Gazouli</name><affiliation wicri:level="1"><nlm:affiliation>Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Goggins, Michael" sort="Goggins, Michael" uniqKey="Goggins M" first="Michael" last="Goggins">Michael Goggins</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Gross, Myron" sort="Gross, Myron" uniqKey="Gross M" first="Myron" last="Gross">Myron Gross</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="1"><nlm:affiliation>Preventive Medicine, University of Southern California, Los Angeles, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Preventive Medicine, University of Southern California, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Hassan, Manal" sort="Hassan, Manal" uniqKey="Hassan M" first="Manal" last="Hassan">Manal Hassan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J" last="Helzlsouer">Kathy J. Helzlsouer</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Nan" sort="Hu, Nan" uniqKey="Hu N" first="Nan" last="Hu">Nan Hu</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Iskierka Jazdzewska, Elzbieta" sort="Iskierka Jazdzewska, Elzbieta" uniqKey="Iskierka Jazdzewska E" first="Elzbieta" last="Iskierka-Jazdzewska">Elzbieta Iskierka-Jazdzewska</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Medical University of Łodz, Łodz, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Hematology, Medical University of Łodz, Łodz</wicri:regionArea></affiliation></author><author><name sortKey="Jenab, Mazda" sort="Jenab, Mazda" uniqKey="Jenab M" first="Mazda" last="Jenab">Mazda Jenab</name><affiliation wicri:level="1"><nlm:affiliation>International Agency for Research on Cancer (IARC), Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J" last="Key">Timothy J. Key</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:affiliation>School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Clinical Medicine, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Eric A" sort="Klein, Eric A" uniqKey="Klein E" first="Eric A" last="Klein">Eric A. Klein</name><affiliation wicri:level="1"><nlm:affiliation>Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio</wicri:regionArea></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Recerca en Epidemiologia Ambiental (CREAL), CIBER Epidemiología y Salud Pública (CIBERESP), Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre de Recerca en Epidemiologia Ambiental (CREAL), CIBER Epidemiología y Salud Pública (CIBERESP)</wicri:regionArea></affiliation></author><author><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Kupcinskas, Juozas" sort="Kupcinskas, Juozas" uniqKey="Kupcinskas J" first="Juozas" last="Kupcinskas">Juozas Kupcinskas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas</wicri:regionArea></affiliation></author><author><name sortKey="Kurtz, Robert C" sort="Kurtz, Robert C" uniqKey="Kurtz R" first="Robert C" last="Kurtz">Robert C. Kurtz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Landi, Maria T" sort="Landi, Maria T" uniqKey="Landi M" first="Maria T" last="Landi">Maria T. Landi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Landi, Stefano" sort="Landi, Stefano" uniqKey="Landi S" first="Stefano" last="Landi">Stefano Landi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, University of Pisa, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Pisa, Pisa</wicri:regionArea></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</wicri:regionArea></affiliation></author><author><name sortKey="Mambrini, Andrea" sort="Mambrini, Andrea" uniqKey="Mambrini A" first="Andrea" last="Mambrini">Andrea Mambrini</name><affiliation wicri:level="1"><nlm:affiliation>Oncology Department, ASL1 Massa Carrara, Massa Carrara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Oncology Department, ASL1 Massa Carrara, Massa Carrara</wicri:regionArea></affiliation></author><author><name sortKey="Mannisto, Satu" sort="Mannisto, Satu" uniqKey="Mannisto S" first="Satu" last="Mannisto">Satu Mannisto</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Neale, Rachel E" sort="Neale, Rachel E" uniqKey="Neale R" first="Rachel E" last="Neale">Rachel E. Neale</name><affiliation wicri:level="1"><nlm:affiliation>Department of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Oberg, Ann L" sort="Oberg, Ann L" uniqKey="Oberg A" first="Ann L" last="Oberg">Ann L. Oberg</name><affiliation wicri:level="1"><nlm:affiliation>Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Panico, Salvatore" sort="Panico, Salvatore" uniqKey="Panico S" first="Salvatore" last="Panico">Salvatore Panico</name><affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Medicina Clinica E Chirurgia, Federico II Univeristy, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Medicina Clinica E Chirurgia, Federico II Univeristy, Naples</wicri:regionArea></affiliation></author><author><name sortKey="Patel, Alpa V" sort="Patel, Alpa V" uniqKey="Patel A" first="Alpa V" last="Patel">Alpa V. Patel</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea></affiliation></author><author><name sortKey="Peeters, Petra H M" sort="Peeters, Petra H M" uniqKey="Peeters P" first="Petra H M" last="Peeters">Petra H M. Peeters</name><affiliation wicri:level="1"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="1"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Pezzilli, Raffaele" sort="Pezzilli, Raffaele" uniqKey="Pezzilli R" first="Raffaele" last="Pezzilli">Raffaele Pezzilli</name><affiliation wicri:level="1"><nlm:affiliation>Pancreas Unit, Department of Digestive Diseases and Internal Medicine, Sant'Orsola-Malpighi Hospital, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pancreas Unit, Department of Digestive Diseases and Internal Medicine, Sant'Orsola-Malpighi Hospital, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Porta, Miquel" sort="Porta, Miquel" uniqKey="Porta M" first="Miquel" last="Porta">Miquel Porta</name><affiliation wicri:level="1"><nlm:affiliation>Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital del Mar Institute of Medical Research (IMIM), Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Purdue, Mark" sort="Purdue, Mark" uniqKey="Purdue M" first="Mark" last="Purdue">Mark Purdue</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Quiros, J Ram N" sort="Quiros, J Ram N" uniqKey="Quiros J" first="J Ram N" last="Quiros">J Ram N Quiros</name><affiliation wicri:level="1"><nlm:affiliation>Public Health and Participation Directorate, Asturias, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Public Health and Participation Directorate, Asturias</wicri:regionArea></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Scarpa, Aldo" sort="Scarpa, Aldo" uniqKey="Scarpa A" first="Aldo" last="Scarpa">Aldo Scarpa</name><affiliation wicri:level="1"><nlm:affiliation>ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona</wicri:regionArea></affiliation></author><author><name sortKey="Scelo, Ghislaine" sort="Scelo, Ghislaine" uniqKey="Scelo G" first="Ghislaine" last="Scelo">Ghislaine Scelo</name><affiliation wicri:level="1"><nlm:affiliation>International Agency for Research on Cancer (IARC), Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation wicri:level="1"><nlm:affiliation>Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Silverman, Debra T" sort="Silverman, Debra T" uniqKey="Silverman D" first="Debra T" last="Silverman">Debra T. Silverman</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Soucek, Pavel" sort="Soucek, Pavel" uniqKey="Soucek P" first="Pavel" last="Soucek">Pavel Soucek</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Pharmacogenomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Laboratory of Pharmacogenomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen</wicri:regionArea></affiliation></author><author><name sortKey="Strobel, Oliver" sort="Strobel, Oliver" uniqKey="Strobel O" first="Oliver" last="Strobel">Oliver Strobel</name><affiliation wicri:level="1"><nlm:affiliation>Department of General Surgery, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of General Surgery, University Hospital Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Sund, Malin" sort="Sund, Malin" uniqKey="Sund M" first="Malin" last="Sund">Malin Sund</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgical and Peroperative Sciences, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgical and Peroperative Sciences, Umeå University, Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Malecka Panas, Ewa" sort="Malecka Panas, Ewa" uniqKey="Malecka Panas E" first="Ewa" last="Małecka-Panas">Ewa Małecka-Panas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Digestive Tract Diseases, Medical University of Łodz, Łodz, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Digestive Tract Diseases, Medical University of Łodz, Łodz</wicri:regionArea></affiliation></author><author><name sortKey="Taylor, Philip R" sort="Taylor, Philip R" uniqKey="Taylor P" first="Philip R" last="Taylor">Philip R. Taylor</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Tavano, Francesca" sort="Tavano, Francesca" uniqKey="Tavano F" first="Francesca" last="Tavano">Francesca Tavano</name><affiliation wicri:level="1"><nlm:affiliation>Division of Gastroenterology and Research Laboratory, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Gastroenterology and Research Laboratory, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo</wicri:regionArea></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Thornquist, Mark" sort="Thornquist, Mark" uniqKey="Thornquist M" first="Mark" last="Thornquist">Mark Thornquist</name><affiliation wicri:level="1"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Tobias, Geoffrey S" sort="Tobias, Geoffrey S" uniqKey="Tobias G" first="Geoffrey S" last="Tobias">Geoffrey S. Tobias</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Vashist, Yogesh" sort="Vashist, Yogesh" uniqKey="Vashist Y" first="Yogesh" last="Vashist">Yogesh Vashist</name><affiliation wicri:level="1"><nlm:affiliation>Department of General, Visceral and Thoracic Surgery, University Hamburg-Eppendorf, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of General, Visceral and Thoracic Surgery, University Hamburg-Eppendorf, Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Vodicka, Pavel" sort="Vodicka, Pavel" uniqKey="Vodicka P" first="Pavel" last="Vodicka">Pavel Vodicka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague</wicri:regionArea></affiliation></author><author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name><affiliation wicri:level="1"><nlm:affiliation>Department of Social and Preventive Medicine, University at Buffalo, Buffalo, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Social and Preventive Medicine, University at Buffalo, Buffalo, New York</wicri:regionArea></affiliation></author><author><name sortKey="Wentzensen, Nicolas" sort="Wentzensen, Nicolas" uniqKey="Wentzensen N" first="Nicolas" last="Wentzensen">Nicolas Wentzensen</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Herbert" sort="Yu, Herbert" uniqKey="Yu H" first="Herbert" last="Yu">Herbert Yu</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Kai" sort="Yu, Kai" uniqKey="Yu K" first="Kai" last="Yu">Kai Yu</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Zeleniuch Jacquotte, Anne" sort="Zeleniuch Jacquotte, Anne" uniqKey="Zeleniuch Jacquotte A" first="Anne" last="Zeleniuch-Jacquotte">Anne Zeleniuch-Jacquotte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Medicine, New York University School of Medicine, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation wicri:level="1"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA,.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</wicri:regionArea></affiliation></author><author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A" last="Risch">Harvey A. Risch</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut</wicri:regionArea></affiliation></author><author><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J" last="Jacobs">Eric J. Jacobs</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea></affiliation></author><author><name sortKey="Li, Donghui" sort="Li, Donghui" uniqKey="Li D" first="Donghui" last="Li">Donghui Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Fuchs, Charles" sort="Fuchs, Charles" uniqKey="Fuchs C" first="Charles" last="Fuchs">Charles Fuchs</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Hoover, Robert" sort="Hoover, Robert" uniqKey="Hoover R" first="Robert" last="Hoover">Robert Hoover</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Petersen, Gloria M" sort="Petersen, Gloria M" uniqKey="Petersen G" first="Gloria M" last="Petersen">Gloria M. Petersen</name><affiliation wicri:level="1"><nlm:affiliation>Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Stolzenberg Solomon, Rachael S" sort="Stolzenberg Solomon, Rachael S" uniqKey="Stolzenberg Solomon R" first="Rachael S" last="Stolzenberg-Solomon">Rachael S. Stolzenberg-Solomon</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Wolpin, Brian M" sort="Wolpin, Brian M" uniqKey="Wolpin B" first="Brian M" last="Wolpin">Brian M. Wolpin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Alison P" sort="Klein, Alison P" uniqKey="Klein A" first="Alison P" last="Klein">Alison P. Klein</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation wicri:level="1"><nlm:affiliation>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Amundadottir, Laufey T" sort="Amundadottir, Laufey T" uniqKey="Amundadottir L" first="Laufey T" last="Amundadottir">Laufey T. Amundadottir</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27579533</idno><idno type="pmid">27579533</idno><idno type="doi">10.18632/oncotarget.11041</idno><idno type="wicri:Area/PubMed/Corpus">001742</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001742</idno><idno type="wicri:Area/PubMed/Curation">001719</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001719</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21.</title><author><name sortKey="Zhang, Mingfeng" sort="Zhang, Mingfeng" uniqKey="Zhang M" first="Mingfeng" last="Zhang">Mingfeng Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Obazee, Ofure" sort="Obazee, Ofure" uniqKey="Obazee O" first="Ofure" last="Obazee">Ofure Obazee</name><affiliation wicri:level="1"><nlm:affiliation>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Jia, Jinping" sort="Jia, Jinping" uniqKey="Jia J" first="Jinping" last="Jia">Jinping Jia</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Childs, Erica J" sort="Childs, Erica J" uniqKey="Childs E" first="Erica J" last="Childs">Erica J. Childs</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Hoskins, Jason" sort="Hoskins, Jason" uniqKey="Hoskins J" first="Jason" last="Hoskins">Jason Hoskins</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Figlioli, Gisella" sort="Figlioli, Gisella" uniqKey="Figlioli G" first="Gisella" last="Figlioli">Gisella Figlioli</name><affiliation wicri:level="1"><nlm:affiliation>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Mocci, Evelina" sort="Mocci, Evelina" uniqKey="Mocci E" first="Evelina" last="Mocci">Evelina Mocci</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Collins, Irene" sort="Collins, Irene" uniqKey="Collins I" first="Irene" last="Collins">Irene Collins</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Chung, Charles C" sort="Chung, Charles C" uniqKey="Chung C" first="Charles C" last="Chung">Charles C. Chung</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Hautman, Christopher" sort="Hautman, Christopher" uniqKey="Hautman C" first="Christopher" last="Hautman">Christopher Hautman</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Arslan, Alan A" sort="Arslan, Alan A" uniqKey="Arslan A" first="Alan A" last="Arslan">Alan A. Arslan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Beane Freeman, Laura" sort="Beane Freeman, Laura" uniqKey="Beane Freeman L" first="Laura" last="Beane-Freeman">Laura Beane-Freeman</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Bracci, Paige M" sort="Bracci, Paige M" uniqKey="Bracci P" first="Paige M" last="Bracci">Paige M. Bracci</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California</wicri:regionArea></affiliation></author><author><name sortKey="Buring, Julie" sort="Buring, Julie" uniqKey="Buring J" first="Julie" last="Buring">Julie Buring</name><affiliation wicri:level="1"><nlm:affiliation>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J" last="Duell">Eric J. Duell</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology (ICO), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology (ICO), Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation wicri:level="1"><nlm:affiliation>Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Goodman, Gary E" sort="Goodman, Gary E" uniqKey="Goodman G" first="Gary E" last="Goodman">Gary E. Goodman</name><affiliation wicri:level="1"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Goodman, Phyllis J" sort="Goodman, Phyllis J" uniqKey="Goodman P" first="Phyllis J" last="Goodman">Phyllis J. Goodman</name><affiliation wicri:level="1"><nlm:affiliation>Southwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Southwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Kamineni, Aruna" sort="Kamineni, Aruna" uniqKey="Kamineni A" first="Aruna" last="Kamineni">Aruna Kamineni</name><affiliation wicri:level="1"><nlm:affiliation>Group Health Research Institute, Seattle, Washington, USA,.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute, Seattle, Washington, USA</wicri:regionArea></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N" last="Kolonel">Laurence N. Kolonel</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</wicri:regionArea></affiliation></author><author><name sortKey="Kulke, Matthew H" sort="Kulke, Matthew H" uniqKey="Kulke M" first="Matthew H" last="Kulke">Matthew H. Kulke</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Malats, Nuria" sort="Malats, Nuria" uniqKey="Malats N" first="Núria" last="Malats">Núria Malats</name><affiliation wicri:level="1"><nlm:affiliation>Genetic and Molecular Epidemiology Group, CNIO-Spanish National Cancer Research Centre, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, CNIO-Spanish National Cancer Research Centre, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Olson, Sara H" sort="Olson, Sara H" uniqKey="Olson S" first="Sara H" last="Olson">Sara H. Olson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Sesso, Howard D" sort="Sesso, Howard D" uniqKey="Sesso H" first="Howard D" last="Sesso">Howard D. Sesso</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Visvanathan, Kala" sort="Visvanathan, Kala" uniqKey="Visvanathan K" first="Kala" last="Visvanathan">Kala Visvanathan</name><affiliation wicri:level="1"><nlm:affiliation>Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation wicri:level="1"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Abnet, Christian C" sort="Abnet, Christian C" uniqKey="Abnet C" first="Christian C" last="Abnet">Christian C. Abnet</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Andreotti, Gabriella" sort="Andreotti, Gabriella" uniqKey="Andreotti G" first="Gabriella" last="Andreotti">Gabriella Andreotti</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Brais, Lauren" sort="Brais, Lauren" uniqKey="Brais L" first="Lauren" last="Brais">Lauren Brais</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name><affiliation wicri:level="1"><nlm:affiliation>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea></affiliation></author><author><name sortKey="Basso, Daniela" sort="Basso, Daniela" uniqKey="Basso D" first="Daniela" last="Basso">Daniela Basso</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, University Hospital of Padova, Padua, Italy,.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Laboratory Medicine, University Hospital of Padova, Padua, Italy</wicri:regionArea></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation wicri:level="1"><nlm:affiliation>Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health Team, F-94805, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health Team, F-94805, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Bijlsma, Maarten F" sort="Bijlsma, Maarten F" uniqKey="Bijlsma M" first="Maarten F" last="Bijlsma">Maarten F. Bijlsma</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory for Experimental Oncology and Radiobiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Laboratory for Experimental Oncology and Radiobiology, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Burdette, Laurie" sort="Burdette, Laurie" uniqKey="Burdette L" first="Laurie" last="Burdette">Laurie Burdette</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Campa, Daniele" sort="Campa, Daniele" uniqKey="Campa D" first="Daniele" last="Campa">Daniele Campa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, University of Pisa, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Pisa, Pisa</wicri:regionArea></affiliation></author><author><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E" last="Caporaso">Neil E. Caporaso</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Capurso, Gabriele" sort="Capurso, Gabriele" uniqKey="Capurso G" first="Gabriele" last="Capurso">Gabriele Capurso</name><affiliation wicri:level="1"><nlm:affiliation>Digestive and Liver Disease Unit, 'Sapienza' University of Rome, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Digestive and Liver Disease Unit, 'Sapienza' University of Rome, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Cavestro, Giulia Martina" sort="Cavestro, Giulia Martina" uniqKey="Cavestro G" first="Giulia Martina" last="Cavestro">Giulia Martina Cavestro</name><affiliation wicri:level="1"><nlm:affiliation>Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Cotterchio, Michelle" sort="Cotterchio, Michelle" uniqKey="Cotterchio M" first="Michelle" last="Cotterchio">Michelle Cotterchio</name><affiliation wicri:level="1"><nlm:affiliation>Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Costello, Eithne" sort="Costello, Eithne" uniqKey="Costello E" first="Eithne" last="Costello">Eithne Costello</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool</wicri:regionArea></affiliation></author><author><name sortKey="Elena, Joanne" sort="Elena, Joanne" uniqKey="Elena J" first="Joanne" last="Elena">Joanne Elena</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Boggi, Ugo" sort="Boggi, Ugo" uniqKey="Boggi U" first="Ugo" last="Boggi">Ugo Boggi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Unit of Experimental Surgical Pathology, University Hospital of Pisa, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Surgery, Unit of Experimental Surgical Pathology, University Hospital of Pisa, Pisa</wicri:regionArea></affiliation></author><author><name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J Michael" last="Gaziano">J Michael Gaziano</name><affiliation wicri:level="1"><nlm:affiliation>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Gazouli, Maria" sort="Gazouli, Maria" uniqKey="Gazouli M" first="Maria" last="Gazouli">Maria Gazouli</name><affiliation wicri:level="1"><nlm:affiliation>Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Goggins, Michael" sort="Goggins, Michael" uniqKey="Goggins M" first="Michael" last="Goggins">Michael Goggins</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Gross, Myron" sort="Gross, Myron" uniqKey="Gross M" first="Myron" last="Gross">Myron Gross</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="1"><nlm:affiliation>Preventive Medicine, University of Southern California, Los Angeles, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Preventive Medicine, University of Southern California, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Hassan, Manal" sort="Hassan, Manal" uniqKey="Hassan M" first="Manal" last="Hassan">Manal Hassan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J" last="Helzlsouer">Kathy J. Helzlsouer</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Nan" sort="Hu, Nan" uniqKey="Hu N" first="Nan" last="Hu">Nan Hu</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Iskierka Jazdzewska, Elzbieta" sort="Iskierka Jazdzewska, Elzbieta" uniqKey="Iskierka Jazdzewska E" first="Elzbieta" last="Iskierka-Jazdzewska">Elzbieta Iskierka-Jazdzewska</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Medical University of Łodz, Łodz, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Hematology, Medical University of Łodz, Łodz</wicri:regionArea></affiliation></author><author><name sortKey="Jenab, Mazda" sort="Jenab, Mazda" uniqKey="Jenab M" first="Mazda" last="Jenab">Mazda Jenab</name><affiliation wicri:level="1"><nlm:affiliation>International Agency for Research on Cancer (IARC), Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J" last="Key">Timothy J. Key</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:affiliation>School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Clinical Medicine, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Eric A" sort="Klein, Eric A" uniqKey="Klein E" first="Eric A" last="Klein">Eric A. Klein</name><affiliation wicri:level="1"><nlm:affiliation>Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio</wicri:regionArea></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Recerca en Epidemiologia Ambiental (CREAL), CIBER Epidemiología y Salud Pública (CIBERESP), Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre de Recerca en Epidemiologia Ambiental (CREAL), CIBER Epidemiología y Salud Pública (CIBERESP)</wicri:regionArea></affiliation></author><author><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Kupcinskas, Juozas" sort="Kupcinskas, Juozas" uniqKey="Kupcinskas J" first="Juozas" last="Kupcinskas">Juozas Kupcinskas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas</wicri:regionArea></affiliation></author><author><name sortKey="Kurtz, Robert C" sort="Kurtz, Robert C" uniqKey="Kurtz R" first="Robert C" last="Kurtz">Robert C. Kurtz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Landi, Maria T" sort="Landi, Maria T" uniqKey="Landi M" first="Maria T" last="Landi">Maria T. Landi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Landi, Stefano" sort="Landi, Stefano" uniqKey="Landi S" first="Stefano" last="Landi">Stefano Landi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, University of Pisa, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Pisa, Pisa</wicri:regionArea></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</wicri:regionArea></affiliation></author><author><name sortKey="Mambrini, Andrea" sort="Mambrini, Andrea" uniqKey="Mambrini A" first="Andrea" last="Mambrini">Andrea Mambrini</name><affiliation wicri:level="1"><nlm:affiliation>Oncology Department, ASL1 Massa Carrara, Massa Carrara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Oncology Department, ASL1 Massa Carrara, Massa Carrara</wicri:regionArea></affiliation></author><author><name sortKey="Mannisto, Satu" sort="Mannisto, Satu" uniqKey="Mannisto S" first="Satu" last="Mannisto">Satu Mannisto</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Neale, Rachel E" sort="Neale, Rachel E" uniqKey="Neale R" first="Rachel E" last="Neale">Rachel E. Neale</name><affiliation wicri:level="1"><nlm:affiliation>Department of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Oberg, Ann L" sort="Oberg, Ann L" uniqKey="Oberg A" first="Ann L" last="Oberg">Ann L. Oberg</name><affiliation wicri:level="1"><nlm:affiliation>Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Panico, Salvatore" sort="Panico, Salvatore" uniqKey="Panico S" first="Salvatore" last="Panico">Salvatore Panico</name><affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Medicina Clinica E Chirurgia, Federico II Univeristy, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Medicina Clinica E Chirurgia, Federico II Univeristy, Naples</wicri:regionArea></affiliation></author><author><name sortKey="Patel, Alpa V" sort="Patel, Alpa V" uniqKey="Patel A" first="Alpa V" last="Patel">Alpa V. Patel</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea></affiliation></author><author><name sortKey="Peeters, Petra H M" sort="Peeters, Petra H M" uniqKey="Peeters P" first="Petra H M" last="Peeters">Petra H M. Peeters</name><affiliation wicri:level="1"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="1"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Pezzilli, Raffaele" sort="Pezzilli, Raffaele" uniqKey="Pezzilli R" first="Raffaele" last="Pezzilli">Raffaele Pezzilli</name><affiliation wicri:level="1"><nlm:affiliation>Pancreas Unit, Department of Digestive Diseases and Internal Medicine, Sant'Orsola-Malpighi Hospital, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pancreas Unit, Department of Digestive Diseases and Internal Medicine, Sant'Orsola-Malpighi Hospital, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Porta, Miquel" sort="Porta, Miquel" uniqKey="Porta M" first="Miquel" last="Porta">Miquel Porta</name><affiliation wicri:level="1"><nlm:affiliation>Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital del Mar Institute of Medical Research (IMIM), Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Purdue, Mark" sort="Purdue, Mark" uniqKey="Purdue M" first="Mark" last="Purdue">Mark Purdue</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Quiros, J Ram N" sort="Quiros, J Ram N" uniqKey="Quiros J" first="J Ram N" last="Quiros">J Ram N Quiros</name><affiliation wicri:level="1"><nlm:affiliation>Public Health and Participation Directorate, Asturias, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Public Health and Participation Directorate, Asturias</wicri:regionArea></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Scarpa, Aldo" sort="Scarpa, Aldo" uniqKey="Scarpa A" first="Aldo" last="Scarpa">Aldo Scarpa</name><affiliation wicri:level="1"><nlm:affiliation>ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona</wicri:regionArea></affiliation></author><author><name sortKey="Scelo, Ghislaine" sort="Scelo, Ghislaine" uniqKey="Scelo G" first="Ghislaine" last="Scelo">Ghislaine Scelo</name><affiliation wicri:level="1"><nlm:affiliation>International Agency for Research on Cancer (IARC), Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation wicri:level="1"><nlm:affiliation>Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Silverman, Debra T" sort="Silverman, Debra T" uniqKey="Silverman D" first="Debra T" last="Silverman">Debra T. Silverman</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Soucek, Pavel" sort="Soucek, Pavel" uniqKey="Soucek P" first="Pavel" last="Soucek">Pavel Soucek</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Pharmacogenomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Laboratory of Pharmacogenomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen</wicri:regionArea></affiliation></author><author><name sortKey="Strobel, Oliver" sort="Strobel, Oliver" uniqKey="Strobel O" first="Oliver" last="Strobel">Oliver Strobel</name><affiliation wicri:level="1"><nlm:affiliation>Department of General Surgery, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of General Surgery, University Hospital Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Sund, Malin" sort="Sund, Malin" uniqKey="Sund M" first="Malin" last="Sund">Malin Sund</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgical and Peroperative Sciences, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgical and Peroperative Sciences, Umeå University, Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Malecka Panas, Ewa" sort="Malecka Panas, Ewa" uniqKey="Malecka Panas E" first="Ewa" last="Małecka-Panas">Ewa Małecka-Panas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Digestive Tract Diseases, Medical University of Łodz, Łodz, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Digestive Tract Diseases, Medical University of Łodz, Łodz</wicri:regionArea></affiliation></author><author><name sortKey="Taylor, Philip R" sort="Taylor, Philip R" uniqKey="Taylor P" first="Philip R" last="Taylor">Philip R. Taylor</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Tavano, Francesca" sort="Tavano, Francesca" uniqKey="Tavano F" first="Francesca" last="Tavano">Francesca Tavano</name><affiliation wicri:level="1"><nlm:affiliation>Division of Gastroenterology and Research Laboratory, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Gastroenterology and Research Laboratory, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo</wicri:regionArea></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Thornquist, Mark" sort="Thornquist, Mark" uniqKey="Thornquist M" first="Mark" last="Thornquist">Mark Thornquist</name><affiliation wicri:level="1"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Tobias, Geoffrey S" sort="Tobias, Geoffrey S" uniqKey="Tobias G" first="Geoffrey S" last="Tobias">Geoffrey S. Tobias</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Vashist, Yogesh" sort="Vashist, Yogesh" uniqKey="Vashist Y" first="Yogesh" last="Vashist">Yogesh Vashist</name><affiliation wicri:level="1"><nlm:affiliation>Department of General, Visceral and Thoracic Surgery, University Hamburg-Eppendorf, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of General, Visceral and Thoracic Surgery, University Hamburg-Eppendorf, Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Vodicka, Pavel" sort="Vodicka, Pavel" uniqKey="Vodicka P" first="Pavel" last="Vodicka">Pavel Vodicka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague</wicri:regionArea></affiliation></author><author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name><affiliation wicri:level="1"><nlm:affiliation>Department of Social and Preventive Medicine, University at Buffalo, Buffalo, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Social and Preventive Medicine, University at Buffalo, Buffalo, New York</wicri:regionArea></affiliation></author><author><name sortKey="Wentzensen, Nicolas" sort="Wentzensen, Nicolas" uniqKey="Wentzensen N" first="Nicolas" last="Wentzensen">Nicolas Wentzensen</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Herbert" sort="Yu, Herbert" uniqKey="Yu H" first="Herbert" last="Yu">Herbert Yu</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Kai" sort="Yu, Kai" uniqKey="Yu K" first="Kai" last="Yu">Kai Yu</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Zeleniuch Jacquotte, Anne" sort="Zeleniuch Jacquotte, Anne" uniqKey="Zeleniuch Jacquotte A" first="Anne" last="Zeleniuch-Jacquotte">Anne Zeleniuch-Jacquotte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Medicine, New York University School of Medicine, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation wicri:level="1"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA,.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</wicri:regionArea></affiliation></author><author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A" last="Risch">Harvey A. Risch</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut</wicri:regionArea></affiliation></author><author><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J" last="Jacobs">Eric J. Jacobs</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea></affiliation></author><author><name sortKey="Li, Donghui" sort="Li, Donghui" uniqKey="Li D" first="Donghui" last="Li">Donghui Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Fuchs, Charles" sort="Fuchs, Charles" uniqKey="Fuchs C" first="Charles" last="Fuchs">Charles Fuchs</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Hoover, Robert" sort="Hoover, Robert" uniqKey="Hoover R" first="Robert" last="Hoover">Robert Hoover</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Petersen, Gloria M" sort="Petersen, Gloria M" uniqKey="Petersen G" first="Gloria M" last="Petersen">Gloria M. Petersen</name><affiliation wicri:level="1"><nlm:affiliation>Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Stolzenberg Solomon, Rachael S" sort="Stolzenberg Solomon, Rachael S" uniqKey="Stolzenberg Solomon R" first="Rachael S" last="Stolzenberg-Solomon">Rachael S. Stolzenberg-Solomon</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Wolpin, Brian M" sort="Wolpin, Brian M" uniqKey="Wolpin B" first="Brian M" last="Wolpin">Brian M. Wolpin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Alison P" sort="Klein, Alison P" uniqKey="Klein A" first="Alison P" last="Klein">Alison P. Klein</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation wicri:level="1"><nlm:affiliation>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Amundadottir, Laufey T" sort="Amundadottir, Laufey T" uniqKey="Amundadottir L" first="Laufey T" last="Amundadottir">Laufey T. Amundadottir</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author></analytic><series><title level="j">Oncotarget</title><idno type="eISSN">1949-2553</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genome-wide association studies (GWAS) have identified common pancreatic cancer susceptibility variants at 13 chromosomal loci in individuals of European descent. To identify new susceptibility variants, we performed imputation based on 1000 Genomes (1000G) Project data and association analysis using 5,107 case and 8,845 control subjects from 27 cohort and case-control studies that participated in the PanScan I-III GWAS. This analysis, in combination with a two-staged replication in an additional 6,076 case and 7,555 control subjects from the PANcreatic Disease ReseArch (PANDoRA) and Pancreatic Cancer Case-Control (PanC4) Consortia uncovered 3 new pancreatic cancer risk signals marked by single nucleotide polymorphisms (SNPs) rs2816938 at chromosome 1q32.1 (per allele odds ratio (OR) = 1.20, P = 4.88x10 -15), rs10094872 at 8q24.21 (OR = 1.15, P = 3.22x10 -9) and rs35226131 at 5p15.33 (OR = 0.71, P = 1.70x10 -8). These SNPs represent independent risk variants at previously identified pancreatic cancer risk loci on chr1q32.1 ( NR5A2), chr8q24.21 ( MYC) and chr5p15.33 ( CLPTM1L- TERT) as per analyses conditioned on previously reported susceptibility variants. We assessed expression of candidate genes at the three risk loci in histologically normal ( n = 10) and tumor ( n = 8) derived pancreatic tissue samples and observed a marked reduction of NR5A2 expression (chr1q32.1) in the tumors (fold change -7.6, P = 5.7x10 -8). This finding was validated in a second set of paired ( n = 20) histologically normal and tumor derived pancreatic tissue samples (average fold change for three NR5A2 isoforms -31.3 to -95.7, P = 7.5x10 -4-2.0x10 -3). Our study has identified new susceptibility variants independently conferring pancreatic cancer risk that merit functional follow-up to identify target genes and explain the underlying biology.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27579533</PMID><DateCreated><Year>2016</Year><Month>08</Month><Day>31</Day></DateCreated><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1949-2553</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>41</Issue><PubDate><Year>2016</Year><Month>Oct</Month><Day>11</Day></PubDate></JournalIssue><Title>Oncotarget</Title><ISOAbbreviation>Oncotarget</ISOAbbreviation></Journal><ArticleTitle>Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21.</ArticleTitle><Pagination><MedlinePgn>66328-66343</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.18632/oncotarget.11041</ELocationID><Abstract><AbstractText>Genome-wide association studies (GWAS) have identified common pancreatic cancer susceptibility variants at 13 chromosomal loci in individuals of European descent. To identify new susceptibility variants, we performed imputation based on 1000 Genomes (1000G) Project data and association analysis using 5,107 case and 8,845 control subjects from 27 cohort and case-control studies that participated in the PanScan I-III GWAS. This analysis, in combination with a two-staged replication in an additional 6,076 case and 7,555 control subjects from the PANcreatic Disease ReseArch (PANDoRA) and Pancreatic Cancer Case-Control (PanC4) Consortia uncovered 3 new pancreatic cancer risk signals marked by single nucleotide polymorphisms (SNPs) rs2816938 at chromosome 1q32.1 (per allele odds ratio (OR) = 1.20, P = 4.88x10 -15), rs10094872 at 8q24.21 (OR = 1.15, P = 3.22x10 -9) and rs35226131 at 5p15.33 (OR = 0.71, P = 1.70x10 -8). These SNPs represent independent risk variants at previously identified pancreatic cancer risk loci on chr1q32.1 ( NR5A2), chr8q24.21 ( MYC) and chr5p15.33 ( CLPTM1L- TERT) as per analyses conditioned on previously reported susceptibility variants. We assessed expression of candidate genes at the three risk loci in histologically normal ( n = 10) and tumor ( n = 8) derived pancreatic tissue samples and observed a marked reduction of NR5A2 expression (chr1q32.1) in the tumors (fold change -7.6, P = 5.7x10 -8). This finding was validated in a second set of paired ( n = 20) histologically normal and tumor derived pancreatic tissue samples (average fold change for three NR5A2 isoforms -31.3 to -95.7, P = 7.5x10 -4-2.0x10 -3). Our study has identified new susceptibility variants independently conferring pancreatic cancer risk that merit functional follow-up to identify target genes and explain the underlying biology.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Mingfeng</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Zhaoming</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Obazee</LastName><ForeName>Ofure</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jia</LastName><ForeName>Jinping</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Childs</LastName><ForeName>Erica J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoskins</LastName><ForeName>Jason</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Figlioli</LastName><ForeName>Gisella</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mocci</LastName><ForeName>Evelina</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Collins</LastName><ForeName>Irene</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>Charles C</ForeName><Initials>CC</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hautman</LastName><ForeName>Christopher</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arslan</LastName><ForeName>Alan A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>New York University Cancer Institute, New York, New York, USA,.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beane-Freeman</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bracci</LastName><ForeName>Paige M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buring</LastName><ForeName>Julie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duell</LastName><ForeName>Eric J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology (ICO), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gallinger</LastName><ForeName>Steven</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giles</LastName><ForeName>Graham G</ForeName><Initials>GG</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goodman</LastName><ForeName>Gary E</ForeName><Initials>GE</Initials><AffiliationInfo><Affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goodman</LastName><ForeName>Phyllis J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Southwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kamineni</LastName><ForeName>Aruna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Group Health Research Institute, Seattle, Washington, USA,.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kolonel</LastName><ForeName>Laurence N</ForeName><Initials>LN</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kulke</LastName><ForeName>Matthew H</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malats</LastName><ForeName>Núria</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Genetic and Molecular Epidemiology Group, CNIO-Spanish National Cancer Research Centre, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olson</LastName><ForeName>Sara H</ForeName><Initials>SH</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sesso</LastName><ForeName>Howard D</ForeName><Initials>HD</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Visvanathan</LastName><ForeName>Kala</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>White</LastName><ForeName>Emily</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, University of Washington, Seattle, Washington, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abnet</LastName><ForeName>Christian C</ForeName><Initials>CC</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Albanes</LastName><ForeName>Demetrius</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andreotti</LastName><ForeName>Gabriella</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brais</LastName><ForeName>Lauren</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bueno-de-Mesquita</LastName><ForeName>H Bas</ForeName><Initials>HB</Initials><AffiliationInfo><Affiliation>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Basso</LastName><ForeName>Daniela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine, University Hospital of Padova, Padua, Italy,.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berndt</LastName><ForeName>Sonja I</ForeName><Initials>SI</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boutron-Ruault</LastName><ForeName>Marie-Christine</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health Team, F-94805, Villejuif, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University Paris Sud, UMRS 1018, F-94805, Villejuif, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>IGR, F-94805, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bijlsma</LastName><ForeName>Maarten F</ForeName><Initials>MF</Initials><AffiliationInfo><Affiliation>Laboratory for Experimental Oncology and Radiobiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brenner</LastName><ForeName>Hermann</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burdette</LastName><ForeName>Laurie</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Campa</LastName><ForeName>Daniele</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Biology, University of Pisa, Pisa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caporaso</LastName><ForeName>Neil E</ForeName><Initials>NE</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Capurso</LastName><ForeName>Gabriele</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Digestive and Liver Disease Unit, 'Sapienza' University of Rome, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cavestro</LastName><ForeName>Giulia Martina</ForeName><Initials>GM</Initials><AffiliationInfo><Affiliation>Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cotterchio</LastName><ForeName>Michelle</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Costello</LastName><ForeName>Eithne</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elena</LastName><ForeName>Joanne</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boggi</LastName><ForeName>Ugo</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Department of Surgery, Unit of Experimental Surgical Pathology, University Hospital of Pisa, Pisa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaziano</LastName><ForeName>J Michael</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Massachusetts Veteran's Epidemiology, Research, and Information Center, Geriatric Research Education and Clinical Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gazouli</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giovannucci</LastName><ForeName>Edward L</ForeName><Initials>EL</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goggins</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pathology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Oncology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gross</LastName><ForeName>Myron</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory of Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haiman</LastName><ForeName>Christopher A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Preventive Medicine, University of Southern California, Los Angeles, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hassan</LastName><ForeName>Manal</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Helzlsouer</LastName><ForeName>Kathy J</ForeName><Initials>KJ</Initials><AffiliationInfo><Affiliation>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Nan</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hunter</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Harvard School of Public Health, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iskierka-Jazdzewska</LastName><ForeName>Elzbieta</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Hematology, Medical University of Łodz, Łodz, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jenab</LastName><ForeName>Mazda</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>International Agency for Research on Cancer (IARC), Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaaks</LastName><ForeName>Rudolf</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Key</LastName><ForeName>Timothy J</ForeName><Initials>TJ</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khaw</LastName><ForeName>Kay-Tee</ForeName><Initials>KT</Initials><AffiliationInfo><Affiliation>School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klein</LastName><ForeName>Eric A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kogevinas</LastName><ForeName>Manolis</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre de Recerca en Epidemiologia Ambiental (CREAL), CIBER Epidemiología y Salud Pública (CIBERESP), Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>National School of Public Health, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krogh</LastName><ForeName>Vittorio</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kupcinskas</LastName><ForeName>Juozas</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kurtz</LastName><ForeName>Robert C</ForeName><Initials>RC</Initials><AffiliationInfo><Affiliation>Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Landi</LastName><ForeName>Maria T</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Landi</LastName><ForeName>Stefano</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biology, University of Pisa, Pisa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Marchand</LastName><ForeName>Loic</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mambrini</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Oncology Department, ASL1 Massa Carrara, Massa Carrara, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mannisto</LastName><ForeName>Satu</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Milne</LastName><ForeName>Roger L</ForeName><Initials>RL</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neale</LastName><ForeName>Rachel E</ForeName><Initials>RE</Initials><AffiliationInfo><Affiliation>Department of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oberg</LastName><ForeName>Ann L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Panico</LastName><ForeName>Salvatore</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Dipartimento di Medicina Clinica E Chirurgia, Federico II Univeristy, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patel</LastName><ForeName>Alpa V</ForeName><Initials>AV</Initials><AffiliationInfo><Affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peeters</LastName><ForeName>Petra H M</ForeName><Initials>PH</Initials><AffiliationInfo><Affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>Ulrike</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, University of Washington, Seattle, Washington, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pezzilli</LastName><ForeName>Raffaele</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Pancreas Unit, Department of Digestive Diseases and Internal Medicine, Sant'Orsola-Malpighi Hospital, Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Porta</LastName><ForeName>Miquel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Purdue</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quiros</LastName><ForeName>J Ramón</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Public Health and Participation Directorate, Asturias, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riboli</LastName><ForeName>Elio</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rothman</LastName><ForeName>Nathaniel</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scarpa</LastName><ForeName>Aldo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scelo</LastName><ForeName>Ghislaine</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>International Agency for Research on Cancer (IARC), Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shu</LastName><ForeName>Xiao-Ou</ForeName><Initials>XO</Initials><AffiliationInfo><Affiliation>Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silverman</LastName><ForeName>Debra T</ForeName><Initials>DT</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soucek</LastName><ForeName>Pavel</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Laboratory of Pharmacogenomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Strobel</LastName><ForeName>Oliver</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of General Surgery, University Hospital Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sund</LastName><ForeName>Malin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Surgical and Peroperative Sciences, Umeå University, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Małecka-Panas</LastName><ForeName>Ewa</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Digestive Tract Diseases, Medical University of Łodz, Łodz, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taylor</LastName><ForeName>Philip R</ForeName><Initials>PR</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tavano</LastName><ForeName>Francesca</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology and Research Laboratory, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Travis</LastName><ForeName>Ruth C</ForeName><Initials>RC</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thornquist</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tjønneland</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tobias</LastName><ForeName>Geoffrey S</ForeName><Initials>GS</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trichopoulos</LastName><ForeName>Dimitrios</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hellenic Health Foundation, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vashist</LastName><ForeName>Yogesh</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of General, Visceral and Thoracic Surgery, University Hamburg-Eppendorf, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vodicka</LastName><ForeName>Pavel</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Molecular Biology of Cancer, 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ValidYN="Y"><LastName>Yu</LastName><ForeName>Kai</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeleniuch-Jacquotte</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>New York University Cancer Institute, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kooperberg</LastName><ForeName>Charles</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA,.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Risch</LastName><ForeName>Harvey A</ForeName><Initials>HA</Initials><AffiliationInfo><Affiliation>Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacobs</LastName><ForeName>Eric J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Donghui</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fuchs</LastName><ForeName>Charles</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoover</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hartge</LastName><ForeName>Patricia</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chanock</LastName><ForeName>Stephen J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petersen</LastName><ForeName>Gloria M</ForeName><Initials>GM</Initials><AffiliationInfo><Affiliation>Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stolzenberg-Solomon</LastName><ForeName>Rachael S</ForeName><Initials>RS</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wolpin</LastName><ForeName>Brian M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kraft</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klein</LastName><ForeName>Alison P</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, the Bloomberg School of Public Health, Baltimore, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author 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