Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women.
Identifieur interne : 001625 ( PubMed/Curation ); précédent : 001624; suivant : 001626Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women.
Auteurs : Timothy R. Rebbeck [États-Unis] ; Tara M. Friebel [États-Unis] ; Nandita Mitra [États-Unis] ; Fei Wan [États-Unis] ; Stephanie Chen [États-Unis] ; Irene L. Andrulis [Canada] ; Paraskevi Apostolou [Grèce] ; Norbert Arnold [Allemagne] ; Banu K. Arun [États-Unis] ; Daniel Barrowdale [Australie] ; Javier Benitez [Espagne] ; Raanan Berger [Israël] ; Pascaline Berthet [France] ; Ake Borg [Suède] ; Saundra S. Buys [États-Unis] ; Trinidad Caldes [Espagne] ; Jonathan Carter [Australie] ; Jocelyne Chiquette [Canada] ; Kathleen B M. Claes [Belgique] ; Fergus J. Couch [États-Unis] ; Cezary Cybulski [Pologne] ; Mary B. Daly [États-Unis] ; Miguel De La Hoya [Espagne] ; Orland Diez [Espagne] ; Susan M. Domchek [États-Unis] ; Katherine L. Nathanson [États-Unis] ; Katarzyna Durda [Pologne] ; Steve Ellis [Royaume-Uni] ; D Gareth Evans [Royaume-Uni] ; Lenka Foretova [République tchèque] ; Eitan Friedman [Israël] ; Debra Frost [Royaume-Uni] ; Patricia A. Ganz [États-Unis] ; Judy Garber [États-Unis] ; Gord Glendon [Canada] ; Andrew K. Godwin [États-Unis] ; Mark H. Greene [États-Unis] ; Jacek Gronwald [Pologne] ; Eric Hahnen [Allemagne] ; Emily Hallberg [États-Unis] ; Ute Hamann [Allemagne] ; Thomas V O. Hansen [Danemark] ; Evgeny N. Imyanitov [Russie] ; Claudine Isaacs [États-Unis] ; Anna Jakubowska [Pologne] ; Ramunas Janavicius [Lituanie] ; Katarzyna Jaworska-Bieniek [Pologne] ; Esther M. John [États-Unis] ; Beth Y. Karlan [États-Unis] ; Bella Kaufman [Israël] ; Kconfab Investigators [Australie] ; Ava Kwong [Hong Kong] ; Yael Laitman [Israël] ; Christine Lasset [France] ; Conxi Lazaro [Espagne] ; Jenny Lester [États-Unis] ; Niklas Loman [Suède] ; Jan Lubinski [Pologne] ; Siranoush Manoukian [Italie] ; Gillian Mitchell [Australie] ; Marco Montagna [Italie] ; Susan L. Neuhausen [États-Unis] ; Heli Nevanlinna [Finlande] ; Dieter Niederacher [Allemagne] ; Robert L. Nussbaum [États-Unis] ; Kenneth Offit [États-Unis] ; Edith Olah [Hongrie] ; Olufunmilayo I. Olopade [États-Unis] ; Sue Kyung Park [Corée du Sud] ; Marion Piedmonte [États-Unis] ; Paolo Radice [Italie] ; Christine Rappaport-Fuerhauser [Autriche] ; Matti A. Rookus [Pays-Bas] ; Caroline Seynaeve [Pays-Bas] ; Jacques Simard [Canada] ; Christian F. Singer [Autriche] ; Penny Soucy [Canada] ; Melissa Southey [Australie] ; Dominique Stoppa-Lyonnet [France] ; Grzegorz Sukiennicki [Pologne] ; Csilla I. Szabo [États-Unis] ; Mariella Tancredi [Italie] ; Manuel R. Teixeira [Portugal] ; Soo-Hwang Teo [Malaisie] ; Mary Beth Terry [États-Unis] ; Mads Thomassen [Danemark] ; Laima Tihomirova [Lettonie] ; Marc Tischkowitz [Canada] ; Amanda Ewart Toland [États-Unis] ; Aleksandra Toloczko-Grabarek [Pologne] ; Nadine Tung [États-Unis] ; Elizabeth J. Van Rensburg [Afrique du Sud] ; Danylo Villano [États-Unis] ; Shan Wang-Gohrke [Allemagne] ; Barbara Wappenschmidt [Allemagne] ; Jeffrey N. Weitzel [États-Unis] ; Jamal Zidan [Israël] ; Kristin K. Zorn [États-Unis] ; Lesley Mcguffog [Royaume-Uni] ; Douglas Easton [Royaume-Uni] ; Georgia Chenevix-Trench [Australie] ; Antonis C. Antoniou [Royaume-Uni] ; Susan J. Ramus [États-Unis]Source :
- Breast cancer research : BCR [ 1465-542X ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Tumeurs du sein.
- génétique : Tumeurs du sein.
- Allèles, Exons, Femelle, Gène BRCA1, Gène BRCA2, Humains, Hétérozygote, Mutation germinale, Perte d'hétérozygotie, Phénotype, Régions promotrices (génétique), Surveillance de la population.
English descriptors
- KwdEn :
- MESH :
- genetics : Breast Neoplasms.
- pathology : Breast Neoplasms.
- Alleles, Exons, Female, Genes, BRCA1, Genes, BRCA2, Germ-Line Mutation, Heterozygote, Humans, Loss of Heterozygosity, Phenotype, Population Surveillance, Promoter Regions, Genetic.
Abstract
Most BRCA1 or BRCA2 mutation carriers have inherited a single (heterozygous) mutation. Transheterozygotes (TH) who have inherited deleterious mutations in both BRCA1 and BRCA2 are rare, and the consequences of transheterozygosity are poorly understood.
DOI: 10.1186/s13058-016-0768-3
PubMed: 27836010
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pubmed:27836010Le document en format XML
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<author><name sortKey="Carter, Jonathan" sort="Carter, Jonathan" uniqKey="Carter J" first="Jonathan" last="Carter">Jonathan Carter</name>
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<author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B" last="Daly">Mary B. Daly</name>
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<author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name>
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<wicri:regionArea>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Martin Lagos s/n, Madrid</wicri:regionArea>
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<author><name sortKey="Diez, Orland" sort="Diez, Orland" uniqKey="Diez O" first="Orland" last="Diez">Orland Diez</name>
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<author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M" last="Domchek">Susan M. Domchek</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
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<author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L" last="Nathanson">Katherine L. Nathanson</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
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<author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name>
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<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin</wicri:regionArea>
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<author><name sortKey="Ellis, Steve" sort="Ellis, Steve" uniqKey="Ellis S" first="Steve" last="Ellis">Steve Ellis</name>
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<author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D Gareth" last="Evans">D Gareth Evans</name>
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<author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name>
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<author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name>
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<author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A" last="Ganz">Patricia A. Ganz</name>
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<author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name>
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<author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name>
<affiliation wicri:level="1"><nlm:affiliation>Ontario Cancer Genetics Network: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.</nlm:affiliation>
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</author>
<author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K" last="Godwin">Andrew K. Godwin</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Laboratory Medicine, 3901 Rainbow Boulevard, 4019 Wahl Hall East, MS, 3040, Kansas, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, 3901 Rainbow Boulevard, 4019 Wahl Hall East, MS, 3040, Kansas</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H" last="Greene">Mark H. Greene</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Genetics Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clinical Genetics Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hahnen, Eric" sort="Hahnen, Eric" uniqKey="Hahnen E" first="Eric" last="Hahnen">Eric Hahnen</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hallberg, Emily" sort="Hallberg, Emily" uniqKey="Hallberg E" first="Emily" last="Hallberg">Emily Hallberg</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, 13400 E. Scottsdale Blvd., Scottsdale, AZ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, 13400 E. Scottsdale Blvd., Scottsdale, AZ</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation wicri:level="1"><nlm:affiliation>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V O" last="Hansen">Thomas V O. Hansen</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100, Copenhagen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N" last="Imyanitov">Evgeny N. Imyanitov</name>
<affiliation wicri:level="1"><nlm:affiliation>N.N. Petrov Institute of Oncology, St.-Petersburg, 197758, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>N.N. Petrov Institute of Oncology, St.-Petersburg, 197758</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name>
<affiliation wicri:level="1"><nlm:affiliation>Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Hematology, oncology and transfusion medicine center, Santariskiu st, Vilnius, Lithuania.</nlm:affiliation>
<country xml:lang="fr">Lituanie</country>
<wicri:regionArea>Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Hematology, oncology and transfusion medicine center, Santariskiu st, Vilnius</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA, 94538, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA, 94538</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y" last="Karlan">Beth Y. Karlan</name>
<affiliation wicri:level="1"><nlm:affiliation>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaufman, Bella" sort="Kaufman, Bella" uniqKey="Kaufman B" first="Bella" last="Kaufman">Bella Kaufman</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute of Oncology, Chaim Sheba Medical Center, Ramat Gan, 52621, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>The Institute of Oncology, Chaim Sheba Medical Center, Ramat Gan, 52621</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Investigators, Kconfab" sort="Investigators, Kconfab" uniqKey="Investigators K" first="Kconfab" last="Investigators">Kconfab Investigators</name>
<affiliation wicri:level="1"><nlm:affiliation>Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Center, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Center, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kwong, Ava" sort="Kwong, Ava" uniqKey="Kwong A" first="Ava" last="Kwong">Ava Kwong</name>
<affiliation wicri:level="1"><nlm:affiliation>The Hong Kong Hereditary Breast Cancer Family Registry; Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong, Hong Kong.</nlm:affiliation>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>The Hong Kong Hereditary Breast Cancer Family Registry; Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name>
<affiliation wicri:level="1"><nlm:affiliation>The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, 52621, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, 52621</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name>
<affiliation wicri:level="1"><nlm:affiliation>Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, 28 rue Laënnec, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, 28 rue Laënnec, Lyon</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name>
<affiliation wicri:level="1"><nlm:affiliation>Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute) Catalan Institute of Oncology, Gran Via de l'Hospitalet, 199-203, 08908, L'Hospitalet Barcelona, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute) Catalan Institute of Oncology, Gran Via de l'Hospitalet, 199-203, 08908, L'Hospitalet Barcelona, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lester, Jenny" sort="Lester, Jenny" uniqKey="Lester J" first="Jenny" last="Lester">Jenny Lester</name>
<affiliation wicri:level="1"><nlm:affiliation>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Loman, Niklas" sort="Loman, Niklas" uniqKey="Loman N" first="Niklas" last="Loman">Niklas Loman</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Lund University Hospital, Lund, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Oncology, Lund University Hospital, Lund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name>
<affiliation wicri:level="1"><nlm:affiliation>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133, Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mitchell, Gillian" sort="Mitchell, Gillian" uniqKey="Mitchell G" first="Gillian" last="Mitchell">Gillian Mitchell</name>
<affiliation wicri:level="1"><nlm:affiliation>Familial Cancer Centre, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, Melbourne, VIC, 8006, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Familial Cancer Centre, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, Melbourne, VIC, 8006</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name>
<affiliation wicri:level="1"><nlm:affiliation>Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOC - IRCCS, Via Gattamelata 64, Padua, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOC - IRCCS, Via Gattamelata 64, Padua</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L" last="Neuhausen">Susan L. Neuhausen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki, P.O. BOX 700, (Haartmaninkatu 8), 00029, HUS, Helsinki, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki, P.O. BOX 700, (Haartmaninkatu 8), 00029, HUS, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nussbaum, Robert L" sort="Nussbaum, Robert L" uniqKey="Nussbaum R" first="Robert L" last="Nussbaum">Robert L. Nussbaum</name>
<affiliation wicri:level="1"><nlm:affiliation>, 513 Parnassus Ave., HSE 901E, San Francisco, CA, 94143-0794, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>, 513 Parnassus Ave., HSE 901E, San Francisco, CA, 94143-0794</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Genetics Research Laboratory, Department of Medicine, Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10044, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clinical Genetics Research Laboratory, Department of Medicine, Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10044</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.</nlm:affiliation>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Department of Molecular Genetics, National Institute of Oncology, Budapest</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I" last="Olopade">Olufunmilayo I. Olopade</name>
<affiliation wicri:level="1"><nlm:affiliation>, 5841 South Maryland Avenue, MC 2115, Chicago, IL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>, 5841 South Maryland Avenue, MC 2115, Chicago, IL</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Park, Sue Kyung" sort="Park, Sue Kyung" uniqKey="Park S" first="Sue Kyung" last="Park">Sue Kyung Park</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 110-799, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 110-799</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name>
<affiliation wicri:level="1"><nlm:affiliation>NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Elm St & Carlton St, Buffalo, NY, 14263, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Elm St & Carlton St, Buffalo, NY, 14263</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
<affiliation wicri:level="1"><nlm:affiliation>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), c/o Amaedeolab, via GA Amadeo 42, 20133, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), c/o Amaedeolab, via GA Amadeo 42, 20133, Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rappaport Fuerhauser, Christine" sort="Rappaport Fuerhauser, Christine" uniqKey="Rappaport Fuerhauser C" first="Christine" last="Rappaport-Fuerhauser">Christine Rappaport-Fuerhauser</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of OB/GYN, Medical University of Vienna, Waehringer Guertel 18-20, A 1090, Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of OB/GYN, Medical University of Vienna, Waehringer Guertel 18-20, A 1090, Vienna</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A" last="Rookus">Matti A. Rookus</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Netherlands Cancer Institute, P.O. Box 90203, 1000, BE, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Netherlands Cancer Institute, P.O. Box 90203, 1000, BE, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Family Cancer Clinic Erasmus University Medical Center Cancer institute, P.O. Box 5201, 3008, AE, Rotterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Oncology, Family Cancer Clinic Erasmus University Medical Center Cancer institute, P.O. Box 5201, 3008, AE, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<affiliation wicri:level="1"><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F" last="Singer">Christian F. Singer</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, A 1090, Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, A 1090, Vienna</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name>
<affiliation wicri:level="1"><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name>
<affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name>
<affiliation wicri:level="1"><nlm:affiliation>Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris, Cedex 05, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris, Cedex 05</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sukiennicki, Grzegorz" sort="Sukiennicki, Grzegorz" uniqKey="Sukiennicki G" first="Grzegorz" last="Sukiennicki">Grzegorz Sukiennicki</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I" last="Szabo">Csilla I. Szabo</name>
<affiliation wicri:level="1"><nlm:affiliation>National Human Genome Research Institute, National Institutes of Health Building 50, Room 5312, 50 South Drive, MSC 004, Bethesda, MD, 20892-8004, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Human Genome Research Institute, National Institutes of Health Building 50, Room 5312, 50 South Drive, MSC 004, Bethesda, MD, 20892-8004</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tancredi, Mariella" sort="Tancredi, Mariella" uniqKey="Tancredi M" first="Mariella" last="Tancredi">Mariella Tancredi</name>
<affiliation wicri:level="1"><nlm:affiliation>Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R" last="Teixeira">Manuel R. Teixeira</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Department of Genetics, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200-072, Porto</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo-Hwang" last="Teo">Soo-Hwang Teo</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 1 Jalan SS12/1A, Subang Jaya, 47500, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 1 Jalan SS12/1A, Subang Jaya, 47500</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary Beth" last="Terry">Mary Beth Terry</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Columbia University, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Columbia University, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Genetics, Odense University Hospital, Sonder Boulevard 29, Odense C, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Genetics, Odense University Hospital, Sonder Boulevard 29, Odense C</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tihomirova, Laima" sort="Tihomirova, Laima" uniqKey="Tihomirova L" first="Laima" last="Tihomirova">Laima Tihomirova</name>
<affiliation wicri:level="1"><nlm:affiliation>Latvian Biomedical Research and Study Centre, Ratsupites str 1, Riga, Latvia.</nlm:affiliation>
<country xml:lang="fr">Lettonie</country>
<wicri:regionArea>Latvian Biomedical Research and Study Centre, Ratsupites str 1, Riga</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tischkowitz, Marc" sort="Tischkowitz, Marc" uniqKey="Tischkowitz M" first="Marc" last="Tischkowitz">Marc Tischkowitz</name>
<affiliation wicri:level="1"><nlm:affiliation>Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Toland, Amanda Ewart" sort="Toland, Amanda Ewart" uniqKey="Toland A" first="Amanda Ewart" last="Toland">Amanda Ewart Toland</name>
<affiliation wicri:level="1"><nlm:affiliation>Divison of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, 998 Biomedical Research Tower, Columbus, OH, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Divison of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, 998 Biomedical Research Tower, Columbus, OH</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Toloczko Grabarek, Aleksandra" sort="Toloczko Grabarek, Aleksandra" uniqKey="Toloczko Grabarek A" first="Aleksandra" last="Toloczko-Grabarek">Aleksandra Toloczko-Grabarek</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Rensburg, Elizabeth J" sort="Van Rensburg, Elizabeth J" uniqKey="Van Rensburg E" first="Elizabeth J" last="Van Rensburg">Elizabeth J. Van Rensburg</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Private Bag X323, Arcadia, 0007, South Africa.</nlm:affiliation>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Private Bag X323, Arcadia, 0007</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Villano, Danylo" sort="Villano, Danylo" uniqKey="Villano D" first="Danylo" last="Villano">Danylo Villano</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wappenschmidt, Barbara" sort="Wappenschmidt, Barbara" uniqKey="Wappenschmidt B" first="Barbara" last="Wappenschmidt">Barbara Wappenschmidt</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Weitzel, Jeffrey N" sort="Weitzel, Jeffrey N" uniqKey="Weitzel J" first="Jeffrey N" last="Weitzel">Jeffrey N. Weitzel</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California, 91010, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California, 91010</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zidan, Jamal" sort="Zidan, Jamal" uniqKey="Zidan J" first="Jamal" last="Zidan">Jamal Zidan</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Oncology, Rivka Ziv Medical Center, 13000, Zefat, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Institute of Oncology, Rivka Ziv Medical Center, 13000, Zefat</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zorn, Kristin K" sort="Zorn, Kristin K" uniqKey="Zorn K" first="Kristin K" last="Zorn">Kristin K. Zorn</name>
<affiliation wicri:level="1"><nlm:affiliation>, 4301 West Markham Street, Slot 793, Little Rock, AR, 72205, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>, 4301 West Markham Street, Slot 793, Little Rock, AR, 72205</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas" sort="Easton, Douglas" uniqKey="Easton D" first="Douglas" last="Easton">Douglas Easton</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Computational Biology, QIMR Berghofer Institute of Medical Research, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer Institute of Medical Research, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C" last="Antoniou">Antonis C. Antoniou</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J" last="Ramus">Susan J. Ramus</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, California, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, California</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:27836010</idno>
<idno type="pmid">27836010</idno>
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<author><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R" last="Rebbeck">Timothy R. Rebbeck</name>
<affiliation wicri:level="1"><nlm:affiliation>Department Epidemiology, Dana Farber Cancer Institute and Harvard T.H. Chan School of Public Health, 1101 Dana Building, 450 Brookline Avenue, Boston, MA, USA. Timothy_Rebbeck@dfci.harvard.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department Epidemiology, Dana Farber Cancer Institute and Harvard T.H. Chan School of Public Health, 1101 Dana Building, 450 Brookline Avenue, Boston, MA</wicri:regionArea>
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<author><name sortKey="Friebel, Tara M" sort="Friebel, Tara M" uniqKey="Friebel T" first="Tara M" last="Friebel">Tara M. Friebel</name>
<affiliation wicri:level="1"><nlm:affiliation>Department Epidemiology, Dana Farber Cancer Institute and Harvard T.H. Chan School of Public Health, 1101 Dana Building, 450 Brookline Avenue, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department Epidemiology, Dana Farber Cancer Institute and Harvard T.H. Chan School of Public Health, 1101 Dana Building, 450 Brookline Avenue, Boston, MA</wicri:regionArea>
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<author><name sortKey="Mitra, Nandita" sort="Mitra, Nandita" uniqKey="Mitra N" first="Nandita" last="Mitra">Nandita Mitra</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wan, Fei" sort="Wan, Fei" uniqKey="Wan F" first="Fei" last="Wan">Fei Wan</name>
<affiliation wicri:level="1"><nlm:affiliation>Biostatistics Unit, Group Health Research Institute, Seattle, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biostatistics Unit, Group Health Research Institute, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Stephanie" sort="Chen, Stephanie" uniqKey="Chen S" first="Stephanie" last="Chen">Stephanie Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, California, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name>
<affiliation wicri:level="1"><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Apostolou, Paraskevi" sort="Apostolou, Paraskevi" uniqKey="Apostolou P" first="Paraskevi" last="Apostolou">Paraskevi Apostolou</name>
<affiliation wicri:level="1"><nlm:affiliation>Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research "Demokritos", Patriarchou Gregoriou & Neapoleos str. Aghia Paraskevi Attikis, Athens, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research "Demokritos", Patriarchou Gregoriou & Neapoleos str. Aghia Paraskevi Attikis, Athens</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University, Kiel, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University, Kiel</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arun, Banu K" sort="Arun, Banu K" uniqKey="Arun B" first="Banu K" last="Arun">Banu K. Arun</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Breast Medical Oncology and Clinical Cancer Genetics Program, University Of Texas MD Anderson Cancer Center, 1515 Pressler Street, CBP 5, Houston, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Breast Medical Oncology and Clinical Cancer Genetics Program, University Of Texas MD Anderson Cancer Center, 1515 Pressler Street, CBP 5, Houston, TX</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Computational Biology, QIMR Berghofer Institute of Medical Research, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer Institute of Medical Research, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<affiliation wicri:level="1"><nlm:affiliation>Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Berger, Raanan" sort="Berger, Raanan" uniqKey="Berger R" first="Raanan" last="Berger">Raanan Berger</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute of Oncology, Chaim Sheba Medical Center, Ramat Gan, 52621, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>The Institute of Oncology, Chaim Sheba Medical Center, Ramat Gan, 52621</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre François Baclesse, 3 avenue Général Harris, Caen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre François Baclesse, 3 avenue Général Harris, Caen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Borg, Ake" sort="Borg, Ake" uniqKey="Borg A" first="Ake" last="Borg">Ake Borg</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Oncology, Clinical Sciences, Lund University and Skåne University Hospital, Lund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S" last="Buys">Saundra S. Buys</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT, 84112, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT, 84112</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name>
<affiliation wicri:level="1"><nlm:affiliation>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Martin Lagos s/n, Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Martin Lagos s/n, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carter, Jonathan" sort="Carter, Jonathan" uniqKey="Carter J" first="Jonathan" last="Carter">Jonathan Carter</name>
<affiliation wicri:level="1"><nlm:affiliation>Gynaecological Oncology, The University of Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Gynaecological Oncology, The University of Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chiquette, Jocelyne" sort="Chiquette, Jocelyne" uniqKey="Chiquette J" first="Jocelyne" last="Chiquette">Jocelyne Chiquette</name>
<affiliation wicri:level="1"><nlm:affiliation>Unité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Hôpital du Saint-Sacrement, 1050, chemin Sainte-Foy, Québec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Unité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Hôpital du Saint-Sacrement, 1050, chemin Sainte-Foy, Québec</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Claes, Kathleen B M" sort="Claes, Kathleen B M" uniqKey="Claes K" first="Kathleen B M" last="Claes">Kathleen B M. Claes</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000, Gent, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000, Gent</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B" last="Daly">Mary B. Daly</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name>
<affiliation wicri:level="1"><nlm:affiliation>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Martin Lagos s/n, Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Martin Lagos s/n, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Diez, Orland" sort="Diez, Orland" uniqKey="Diez O" first="Orland" last="Diez">Orland Diez</name>
<affiliation wicri:level="1"><nlm:affiliation>Oncogenetics Group, Vall d'Hebron Institute of Oncology (VHIO), Clinical and Molecular Genetics Area, Vall d'Hebron University Hospital, Passeig Vall d'Hebron 119-129, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Oncogenetics Group, Vall d'Hebron Institute of Oncology (VHIO), Clinical and Molecular Genetics Area, Vall d'Hebron University Hospital, Passeig Vall d'Hebron 119-129, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M" last="Domchek">Susan M. Domchek</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L" last="Nathanson">Katherine L. Nathanson</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ellis, Steve" sort="Ellis, Steve" uniqKey="Ellis S" first="Steve" last="Ellis">Steve Ellis</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D Gareth" last="Evans">D Gareth Evans</name>
<affiliation wicri:level="1"><nlm:affiliation>Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust, Manchester</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno, 65653, Czech Republic.</nlm:affiliation>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno, 65653</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name>
<affiliation wicri:level="1"><nlm:affiliation>The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, 52621, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, 52621</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A" last="Ganz">Patricia A. Ganz</name>
<affiliation wicri:level="1"><nlm:affiliation>UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research Jonsson Comprehensive Cancer Center, 650 Charles Young Drive South, Room A2-125 HS, Los Angeles, CA, 90095-6900, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research Jonsson Comprehensive Cancer Center, 650 Charles Young Drive South, Room A2-125 HS, Los Angeles, CA, 90095-6900</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name>
<affiliation wicri:level="1"><nlm:affiliation>Department Epidemiology, Dana Farber Cancer Institute and Harvard T.H. Chan School of Public Health, 1101 Dana Building, 450 Brookline Avenue, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department Epidemiology, Dana Farber Cancer Institute and Harvard T.H. Chan School of Public Health, 1101 Dana Building, 450 Brookline Avenue, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name>
<affiliation wicri:level="1"><nlm:affiliation>Ontario Cancer Genetics Network: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Ontario Cancer Genetics Network: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K" last="Godwin">Andrew K. Godwin</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Laboratory Medicine, 3901 Rainbow Boulevard, 4019 Wahl Hall East, MS, 3040, Kansas, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, 3901 Rainbow Boulevard, 4019 Wahl Hall East, MS, 3040, Kansas</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H" last="Greene">Mark H. Greene</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Genetics Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clinical Genetics Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hahnen, Eric" sort="Hahnen, Eric" uniqKey="Hahnen E" first="Eric" last="Hahnen">Eric Hahnen</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hallberg, Emily" sort="Hallberg, Emily" uniqKey="Hallberg E" first="Emily" last="Hallberg">Emily Hallberg</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, 13400 E. Scottsdale Blvd., Scottsdale, AZ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, 13400 E. Scottsdale Blvd., Scottsdale, AZ</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation wicri:level="1"><nlm:affiliation>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V O" last="Hansen">Thomas V O. Hansen</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100, Copenhagen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N" last="Imyanitov">Evgeny N. Imyanitov</name>
<affiliation wicri:level="1"><nlm:affiliation>N.N. Petrov Institute of Oncology, St.-Petersburg, 197758, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>N.N. Petrov Institute of Oncology, St.-Petersburg, 197758</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name>
<affiliation wicri:level="1"><nlm:affiliation>Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Hematology, oncology and transfusion medicine center, Santariskiu st, Vilnius, Lithuania.</nlm:affiliation>
<country xml:lang="fr">Lituanie</country>
<wicri:regionArea>Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Hematology, oncology and transfusion medicine center, Santariskiu st, Vilnius</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA, 94538, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA, 94538</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y" last="Karlan">Beth Y. Karlan</name>
<affiliation wicri:level="1"><nlm:affiliation>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaufman, Bella" sort="Kaufman, Bella" uniqKey="Kaufman B" first="Bella" last="Kaufman">Bella Kaufman</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute of Oncology, Chaim Sheba Medical Center, Ramat Gan, 52621, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>The Institute of Oncology, Chaim Sheba Medical Center, Ramat Gan, 52621</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Investigators, Kconfab" sort="Investigators, Kconfab" uniqKey="Investigators K" first="Kconfab" last="Investigators">Kconfab Investigators</name>
<affiliation wicri:level="1"><nlm:affiliation>Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Center, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Center, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kwong, Ava" sort="Kwong, Ava" uniqKey="Kwong A" first="Ava" last="Kwong">Ava Kwong</name>
<affiliation wicri:level="1"><nlm:affiliation>The Hong Kong Hereditary Breast Cancer Family Registry; Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong, Hong Kong.</nlm:affiliation>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>The Hong Kong Hereditary Breast Cancer Family Registry; Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name>
<affiliation wicri:level="1"><nlm:affiliation>The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, 52621, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, 52621</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name>
<affiliation wicri:level="1"><nlm:affiliation>Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, 28 rue Laënnec, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, 28 rue Laënnec, Lyon</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name>
<affiliation wicri:level="1"><nlm:affiliation>Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute) Catalan Institute of Oncology, Gran Via de l'Hospitalet, 199-203, 08908, L'Hospitalet Barcelona, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute) Catalan Institute of Oncology, Gran Via de l'Hospitalet, 199-203, 08908, L'Hospitalet Barcelona, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lester, Jenny" sort="Lester, Jenny" uniqKey="Lester J" first="Jenny" last="Lester">Jenny Lester</name>
<affiliation wicri:level="1"><nlm:affiliation>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Loman, Niklas" sort="Loman, Niklas" uniqKey="Loman N" first="Niklas" last="Loman">Niklas Loman</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Lund University Hospital, Lund, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Oncology, Lund University Hospital, Lund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name>
<affiliation wicri:level="1"><nlm:affiliation>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133, Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mitchell, Gillian" sort="Mitchell, Gillian" uniqKey="Mitchell G" first="Gillian" last="Mitchell">Gillian Mitchell</name>
<affiliation wicri:level="1"><nlm:affiliation>Familial Cancer Centre, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, Melbourne, VIC, 8006, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Familial Cancer Centre, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, Melbourne, VIC, 8006</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name>
<affiliation wicri:level="1"><nlm:affiliation>Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOC - IRCCS, Via Gattamelata 64, Padua, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOC - IRCCS, Via Gattamelata 64, Padua</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L" last="Neuhausen">Susan L. Neuhausen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki, P.O. BOX 700, (Haartmaninkatu 8), 00029, HUS, Helsinki, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki, P.O. BOX 700, (Haartmaninkatu 8), 00029, HUS, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nussbaum, Robert L" sort="Nussbaum, Robert L" uniqKey="Nussbaum R" first="Robert L" last="Nussbaum">Robert L. Nussbaum</name>
<affiliation wicri:level="1"><nlm:affiliation>, 513 Parnassus Ave., HSE 901E, San Francisco, CA, 94143-0794, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>, 513 Parnassus Ave., HSE 901E, San Francisco, CA, 94143-0794</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Genetics Research Laboratory, Department of Medicine, Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10044, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clinical Genetics Research Laboratory, Department of Medicine, Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10044</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.</nlm:affiliation>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Department of Molecular Genetics, National Institute of Oncology, Budapest</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I" last="Olopade">Olufunmilayo I. Olopade</name>
<affiliation wicri:level="1"><nlm:affiliation>, 5841 South Maryland Avenue, MC 2115, Chicago, IL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>, 5841 South Maryland Avenue, MC 2115, Chicago, IL</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Park, Sue Kyung" sort="Park, Sue Kyung" uniqKey="Park S" first="Sue Kyung" last="Park">Sue Kyung Park</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 110-799, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 110-799</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name>
<affiliation wicri:level="1"><nlm:affiliation>NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Elm St & Carlton St, Buffalo, NY, 14263, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Elm St & Carlton St, Buffalo, NY, 14263</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
<affiliation wicri:level="1"><nlm:affiliation>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), c/o Amaedeolab, via GA Amadeo 42, 20133, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), c/o Amaedeolab, via GA Amadeo 42, 20133, Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rappaport Fuerhauser, Christine" sort="Rappaport Fuerhauser, Christine" uniqKey="Rappaport Fuerhauser C" first="Christine" last="Rappaport-Fuerhauser">Christine Rappaport-Fuerhauser</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of OB/GYN, Medical University of Vienna, Waehringer Guertel 18-20, A 1090, Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of OB/GYN, Medical University of Vienna, Waehringer Guertel 18-20, A 1090, Vienna</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A" last="Rookus">Matti A. Rookus</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Netherlands Cancer Institute, P.O. Box 90203, 1000, BE, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Netherlands Cancer Institute, P.O. Box 90203, 1000, BE, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Family Cancer Clinic Erasmus University Medical Center Cancer institute, P.O. Box 5201, 3008, AE, Rotterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Oncology, Family Cancer Clinic Erasmus University Medical Center Cancer institute, P.O. Box 5201, 3008, AE, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<affiliation wicri:level="1"><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F" last="Singer">Christian F. Singer</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, A 1090, Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, A 1090, Vienna</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name>
<affiliation wicri:level="1"><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name>
<affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name>
<affiliation wicri:level="1"><nlm:affiliation>Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris, Cedex 05, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris, Cedex 05</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sukiennicki, Grzegorz" sort="Sukiennicki, Grzegorz" uniqKey="Sukiennicki G" first="Grzegorz" last="Sukiennicki">Grzegorz Sukiennicki</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I" last="Szabo">Csilla I. Szabo</name>
<affiliation wicri:level="1"><nlm:affiliation>National Human Genome Research Institute, National Institutes of Health Building 50, Room 5312, 50 South Drive, MSC 004, Bethesda, MD, 20892-8004, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Human Genome Research Institute, National Institutes of Health Building 50, Room 5312, 50 South Drive, MSC 004, Bethesda, MD, 20892-8004</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tancredi, Mariella" sort="Tancredi, Mariella" uniqKey="Tancredi M" first="Mariella" last="Tancredi">Mariella Tancredi</name>
<affiliation wicri:level="1"><nlm:affiliation>Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R" last="Teixeira">Manuel R. Teixeira</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Department of Genetics, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200-072, Porto</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo-Hwang" last="Teo">Soo-Hwang Teo</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 1 Jalan SS12/1A, Subang Jaya, 47500, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 1 Jalan SS12/1A, Subang Jaya, 47500</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary Beth" last="Terry">Mary Beth Terry</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Columbia University, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Columbia University, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Genetics, Odense University Hospital, Sonder Boulevard 29, Odense C, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Genetics, Odense University Hospital, Sonder Boulevard 29, Odense C</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tihomirova, Laima" sort="Tihomirova, Laima" uniqKey="Tihomirova L" first="Laima" last="Tihomirova">Laima Tihomirova</name>
<affiliation wicri:level="1"><nlm:affiliation>Latvian Biomedical Research and Study Centre, Ratsupites str 1, Riga, Latvia.</nlm:affiliation>
<country xml:lang="fr">Lettonie</country>
<wicri:regionArea>Latvian Biomedical Research and Study Centre, Ratsupites str 1, Riga</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tischkowitz, Marc" sort="Tischkowitz, Marc" uniqKey="Tischkowitz M" first="Marc" last="Tischkowitz">Marc Tischkowitz</name>
<affiliation wicri:level="1"><nlm:affiliation>Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Toland, Amanda Ewart" sort="Toland, Amanda Ewart" uniqKey="Toland A" first="Amanda Ewart" last="Toland">Amanda Ewart Toland</name>
<affiliation wicri:level="1"><nlm:affiliation>Divison of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, 998 Biomedical Research Tower, Columbus, OH, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Divison of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, 998 Biomedical Research Tower, Columbus, OH</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Toloczko Grabarek, Aleksandra" sort="Toloczko Grabarek, Aleksandra" uniqKey="Toloczko Grabarek A" first="Aleksandra" last="Toloczko-Grabarek">Aleksandra Toloczko-Grabarek</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Rensburg, Elizabeth J" sort="Van Rensburg, Elizabeth J" uniqKey="Van Rensburg E" first="Elizabeth J" last="Van Rensburg">Elizabeth J. Van Rensburg</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Private Bag X323, Arcadia, 0007, South Africa.</nlm:affiliation>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Private Bag X323, Arcadia, 0007</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Villano, Danylo" sort="Villano, Danylo" uniqKey="Villano D" first="Danylo" last="Villano">Danylo Villano</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wappenschmidt, Barbara" sort="Wappenschmidt, Barbara" uniqKey="Wappenschmidt B" first="Barbara" last="Wappenschmidt">Barbara Wappenschmidt</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Weitzel, Jeffrey N" sort="Weitzel, Jeffrey N" uniqKey="Weitzel J" first="Jeffrey N" last="Weitzel">Jeffrey N. Weitzel</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California, 91010, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California, 91010</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zidan, Jamal" sort="Zidan, Jamal" uniqKey="Zidan J" first="Jamal" last="Zidan">Jamal Zidan</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Oncology, Rivka Ziv Medical Center, 13000, Zefat, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Institute of Oncology, Rivka Ziv Medical Center, 13000, Zefat</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zorn, Kristin K" sort="Zorn, Kristin K" uniqKey="Zorn K" first="Kristin K" last="Zorn">Kristin K. Zorn</name>
<affiliation wicri:level="1"><nlm:affiliation>, 4301 West Markham Street, Slot 793, Little Rock, AR, 72205, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>, 4301 West Markham Street, Slot 793, Little Rock, AR, 72205</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas" sort="Easton, Douglas" uniqKey="Easton D" first="Douglas" last="Easton">Douglas Easton</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Computational Biology, QIMR Berghofer Institute of Medical Research, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer Institute of Medical Research, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C" last="Antoniou">Antonis C. Antoniou</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J" last="Ramus">Susan J. Ramus</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, California, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, California</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Breast cancer research : BCR</title>
<idno type="eISSN">1465-542X</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles</term>
<term>Breast Neoplasms (genetics)</term>
<term>Breast Neoplasms (pathology)</term>
<term>Exons</term>
<term>Female</term>
<term>Genes, BRCA1</term>
<term>Genes, BRCA2</term>
<term>Germ-Line Mutation</term>
<term>Heterozygote</term>
<term>Humans</term>
<term>Loss of Heterozygosity</term>
<term>Phenotype</term>
<term>Population Surveillance</term>
<term>Promoter Regions, Genetic</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Allèles</term>
<term>Exons</term>
<term>Femelle</term>
<term>Gène BRCA1</term>
<term>Gène BRCA2</term>
<term>Humains</term>
<term>Hétérozygote</term>
<term>Mutation germinale</term>
<term>Perte d'hétérozygotie</term>
<term>Phénotype</term>
<term>Régions promotrices (génétique)</term>
<term>Surveillance de la population</term>
<term>Tumeurs du sein (anatomopathologie)</term>
<term>Tumeurs du sein (génétique)</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Alleles</term>
<term>Exons</term>
<term>Female</term>
<term>Genes, BRCA1</term>
<term>Genes, BRCA2</term>
<term>Germ-Line Mutation</term>
<term>Heterozygote</term>
<term>Humans</term>
<term>Loss of Heterozygosity</term>
<term>Phenotype</term>
<term>Population Surveillance</term>
<term>Promoter Regions, Genetic</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Allèles</term>
<term>Exons</term>
<term>Femelle</term>
<term>Gène BRCA1</term>
<term>Gène BRCA2</term>
<term>Humains</term>
<term>Hétérozygote</term>
<term>Mutation germinale</term>
<term>Perte d'hétérozygotie</term>
<term>Phénotype</term>
<term>Régions promotrices (génétique)</term>
<term>Surveillance de la population</term>
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<front><div type="abstract" xml:lang="en">Most BRCA1 or BRCA2 mutation carriers have inherited a single (heterozygous) mutation. Transheterozygotes (TH) who have inherited deleterious mutations in both BRCA1 and BRCA2 are rare, and the consequences of transheterozygosity are poorly understood.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27836010</PMID>
<DateCreated><Year>2016</Year>
<Month>11</Month>
<Day>12</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>08</Month>
<Day>07</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>11</Month>
<Day>03</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1465-542X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>18</Volume>
<Issue>1</Issue>
<PubDate><Year>2016</Year>
<Month>Nov</Month>
<Day>11</Day>
</PubDate>
</JournalIssue>
<Title>Breast cancer research : BCR</Title>
<ISOAbbreviation>Breast Cancer Res.</ISOAbbreviation>
</Journal>
<ArticleTitle>Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women.</ArticleTitle>
<Pagination><MedlinePgn>112</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Most BRCA1 or BRCA2 mutation carriers have inherited a single (heterozygous) mutation. Transheterozygotes (TH) who have inherited deleterious mutations in both BRCA1 and BRCA2 are rare, and the consequences of transheterozygosity are poorly understood.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">From 32,295 female BRCA1/2 mutation carriers, we identified 93 TH (0.3 %). "Cases" were defined as TH, and "controls" were single mutations at BRCA1 (SH1) or BRCA2 (SH2). Matched SH1 "controls" carried a BRCA1 mutation found in the TH "case". Matched SH2 "controls" carried a BRCA2 mutation found in the TH "case". After matching the TH carriers with SH1 or SH2, 91 TH were matched to 9316 SH1, and 89 TH were matched to 3370 SH2.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The majority of TH (45.2 %) involved the three common Jewish mutations. TH were more likely than SH1 and SH2 women to have been ever diagnosed with breast cancer (BC; p = 0.002). TH were more likely to be diagnosed with ovarian cancer (OC) than SH2 (p = 0.017), but not SH1. Age at BC diagnosis was the same in TH vs. SH1 (p = 0.231), but was on average 4.5 years younger in TH than in SH2 (p < 0.001). BC in TH was more likely to be estrogen receptor (ER) positive (p = 0.010) or progesterone receptor (PR) positive (p = 0.013) than in SH1, but less likely to be ER positive (p < 0.001) or PR positive (p = 0.012) than SH2. Among 15 tumors from TH patients, there was no clear pattern of loss of heterozygosity (LOH) for BRCA1 or BRCA2 in either BC or OC.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our observations suggest that clinical TH phenotypes resemble SH1. However, TH breast tumor marker characteristics are phenotypically intermediate to SH1 and SH2.</AbstractText>
</Abstract>
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<Initials>TR</Initials>
<AffiliationInfo><Affiliation>Department Epidemiology, Dana Farber Cancer Institute and Harvard T.H. Chan School of Public Health, 1101 Dana Building, 450 Brookline Avenue, Boston, MA, USA. Timothy_Rebbeck@dfci.harvard.edu.</Affiliation>
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<Initials>TM</Initials>
<AffiliationInfo><Affiliation>Department Epidemiology, Dana Farber Cancer Institute and Harvard T.H. Chan School of Public Health, 1101 Dana Building, 450 Brookline Avenue, Boston, MA, USA.</Affiliation>
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<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Biostatistics Unit, Group Health Research Institute, Seattle, WA, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, California, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Breast Medical Oncology and Clinical Cancer Genetics Program, University Of Texas MD Anderson Cancer Center, 1515 Pressler Street, CBP 5, Houston, TX, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Medical Oncology, Family Cancer Clinic Erasmus University Medical Center Cancer institute, P.O. Box 5201, 3008, AE, Rotterdam, The Netherlands.</Affiliation>
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<Initials>L</Initials>
<AffiliationInfo><Affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.</Affiliation>
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<AffiliationInfo><Affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.</Affiliation>
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<ForeName>Georgia</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Genetics and Computational Biology, QIMR Berghofer Institute of Medical Research, Brisbane, Australia.</Affiliation>
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<ForeName>Antonis C</ForeName>
<Initials>AC</Initials>
<AffiliationInfo><Affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.</Affiliation>
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<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, California, USA.</Affiliation>
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