Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus.
Identifieur interne : 001597 ( PubMed/Curation ); précédent : 001596; suivant : 001598Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus.
Auteurs : Axel Touchard [France] ; Andreas Brust [Australie] ; Fernanda Caldas Cardoso [Australie] ; Yanni K-Y Chin [Australie] ; Volker Herzig [Australie] ; Ai-Hua Jin [Australie] ; Alain Dejean [France] ; Paul F. Alewood [Australie] ; Glenn F. King [Australie] ; Jérôme Orivel [France] ; Pierre Escoubas [France]Source :
- Biochimica et biophysica acta [ 0006-3002 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Ant Venoms, Disulfides.
- Amino Acid Motifs.
Abstract
Most ant venoms consist predominantly of small linear peptides, although some contain disulfide-linked peptides as minor components. However, in striking contrast to other ant species, some Anochetus venoms are composed primarily of disulfide-rich peptides. In this study, we investigated the venom of the ant Anochetus emarginatus with the aim of exploring these novel disulfide-rich peptides.
DOI: 10.1016/j.bbagen.2016.07.027
PubMed: 27474999
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Electronic address: t.axel@hotmail.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR Ecologie des forêts de Guyane (AgroParisTech, CIRAD, CNRS, INRA, Université de Guyane, Université des Antilles), Campus Agronomique, BP 316, 97379 Kourou</wicri:regionArea></affiliation></author><author><name sortKey="Brust, Andreas" sort="Brust, Andreas" uniqKey="Brust A" first="Andreas" last="Brust">Andreas Brust</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072</wicri:regionArea></affiliation></author><author><name sortKey="Cardoso, Fernanda Caldas" sort="Cardoso, Fernanda Caldas" uniqKey="Cardoso F" first="Fernanda Caldas" last="Cardoso">Fernanda Caldas Cardoso</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072</wicri:regionArea></affiliation></author><author><name sortKey="Chin, Yanni K Y" sort="Chin, Yanni K Y" uniqKey="Chin Y" first="Yanni K-Y" last="Chin">Yanni K-Y Chin</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072</wicri:regionArea></affiliation></author><author><name sortKey="Herzig, Volker" sort="Herzig, Volker" uniqKey="Herzig V" first="Volker" last="Herzig">Volker Herzig</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072</wicri:regionArea></affiliation></author><author><name sortKey="Jin, Ai Hua" sort="Jin, Ai Hua" uniqKey="Jin A" first="Ai-Hua" last="Jin">Ai-Hua Jin</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072</wicri:regionArea></affiliation></author><author><name sortKey="Dejean, Alain" sort="Dejean, Alain" uniqKey="Dejean A" first="Alain" last="Dejean">Alain Dejean</name><affiliation wicri:level="1"><nlm:affiliation>CNRS, UMR Ecologie des forêts de Guyane (AgroParisTech, CIRAD, CNRS, INRA, Université de Guyane, Université des Antilles), Campus Agronomique, BP 316, 97379 Kourou, France; CNRS, UMR 5245, Laboratoire Écologie Fonctionnelle et Environnement, 118 route de Narbonne, 31062 Toulouse, France; Université de Toulouse, UPS, INP, Ecolab, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR Ecologie des forêts de Guyane (AgroParisTech, CIRAD, CNRS, INRA, Université de Guyane, Université des Antilles), Campus Agronomique, BP 316, 97379 Kourou, France; CNRS, UMR 5245, Laboratoire Écologie Fonctionnelle et Environnement, 118 route de Narbonne, 31062 Toulouse, France; Université de Toulouse, UPS, INP, Ecolab, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Alewood, Paul F" sort="Alewood, Paul F" uniqKey="Alewood P" first="Paul F" last="Alewood">Paul F. Alewood</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072</wicri:regionArea></affiliation></author><author><name sortKey="King, Glenn F" sort="King, Glenn F" uniqKey="King G" first="Glenn F" last="King">Glenn F. King</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072</wicri:regionArea></affiliation></author><author><name sortKey="Orivel, Jerome" sort="Orivel, Jerome" uniqKey="Orivel J" first="Jérôme" last="Orivel">Jérôme Orivel</name><affiliation wicri:level="1"><nlm:affiliation>CNRS, UMR Ecologie des forêts de Guyane (AgroParisTech, CIRAD, CNRS, INRA, Université de Guyane, Université des Antilles), Campus Agronomique, BP 316, 97379 Kourou, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR Ecologie des forêts de Guyane (AgroParisTech, CIRAD, CNRS, INRA, Université de Guyane, Université des Antilles), Campus Agronomique, BP 316, 97379 Kourou</wicri:regionArea></affiliation></author><author><name sortKey="Escoubas, Pierre" sort="Escoubas, Pierre" uniqKey="Escoubas P" first="Pierre" last="Escoubas">Pierre Escoubas</name><affiliation wicri:level="1"><nlm:affiliation>VenomeTech, 473 Route des Dolines, 06560 Valbonne, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>VenomeTech, 473 Route des Dolines, 06560 Valbonne</wicri:regionArea></affiliation></author></analytic><series><title level="j">Biochimica et biophysica acta</title><idno type="ISSN">0006-3002</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Motifs</term><term>Ant Venoms (chemistry)</term><term>Disulfides (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Disulfures ()</term><term>Motifs d'acides aminés</term><term>Venins de fourmi ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Ant Venoms</term><term>Disulfides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Motifs</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Disulfures</term><term>Motifs d'acides aminés</term><term>Venins de fourmi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Most ant venoms consist predominantly of small linear peptides, although some contain disulfide-linked peptides as minor components. However, in striking contrast to other ant species, some Anochetus venoms are composed primarily of disulfide-rich peptides. In this study, we investigated the venom of the ant Anochetus emarginatus with the aim of exploring these novel disulfide-rich peptides.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27474999</PMID><DateCreated><Year>2016</Year><Month>09</Month><Day>03</Day></DateCreated><DateCompleted><Year>2017</Year><Month>06</Month><Day>26</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0006-3002</ISSN><JournalIssue CitedMedium="Print"><Volume>1860</Volume><Issue>11 Pt A</Issue><PubDate><Year>2016</Year><Month>11</Month></PubDate></JournalIssue><Title>Biochimica et biophysica acta</Title><ISOAbbreviation>Biochim. Biophys. Acta</ISOAbbreviation></Journal><ArticleTitle>Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus.</ArticleTitle><Pagination><MedlinePgn>2553-2562</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0304-4165(16)30274-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbagen.2016.07.027</ELocationID><Abstract><AbstractText Label="BACKGROUND">Most ant venoms consist predominantly of small linear peptides, although some contain disulfide-linked peptides as minor components. However, in striking contrast to other ant species, some Anochetus venoms are composed primarily of disulfide-rich peptides. In this study, we investigated the venom of the ant Anochetus emarginatus with the aim of exploring these novel disulfide-rich peptides.</AbstractText><AbstractText Label="METHODS">The venom peptidome was initially investigated using a combination of reversed-phase HPLC and mass spectrometry, then the amino acid sequences of the major peptides were determined using a combination of Edman degradation and de novo MS/MS sequencing. We focused on one of these peptides, U1-PONTX-Ae1a (Ae1a), because of its novel sequence, which we predicted would form a novel 3D fold. Ae1a was chemically synthesized using Fmoc chemistry and its 3D structure was elucidated using NMR spectroscopy. The peptide was then tested for insecticidal activity and its effect on a range of human ion channels.</AbstractText><AbstractText Label="RESULTS">Seven peptides named poneritoxins (PONTXs) were isolated and sequenced. The three-dimensional structure of synthetic Ae1a revealed a novel, compact scaffold in which a C-terminal β-hairpin is connected to the N-terminal region via two disulfide bonds. Synthetic Ae1a reversibly paralyzed blowflies and inhibited human L-type voltage-gated calcium channels (CaV1).</AbstractText><AbstractText Label="CONCLUSIONS">Poneritoxins from Anochetus emarginatus venom are a novel class of toxins that are structurally unique among animal venoms.</AbstractText><AbstractText Label="GENERAL SIGNIFICANCE">This study demonstrates that Anochetus ant venoms are a rich source of novel ion channel modulating peptides, some of which might be useful leads for the development of biopesticides.</AbstractText><CopyrightInformation>Crown Copyright © 2016. Published by Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Touchard</LastName><ForeName>Axel</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>CNRS, UMR Ecologie des forêts de Guyane (AgroParisTech, CIRAD, CNRS, INRA, Université de Guyane, Université des Antilles), Campus Agronomique, BP 316, 97379 Kourou, France. Electronic address: t.axel@hotmail.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brust</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cardoso</LastName><ForeName>Fernanda Caldas</ForeName><Initials>FC</Initials><AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chin</LastName><ForeName>Yanni K-Y</ForeName><Initials>YK</Initials><AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herzig</LastName><ForeName>Volker</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>Ai-Hua</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dejean</LastName><ForeName>Alain</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>CNRS, UMR Ecologie des forêts de Guyane (AgroParisTech, CIRAD, CNRS, INRA, Université de Guyane, Université des Antilles), Campus Agronomique, BP 316, 97379 Kourou, France; CNRS, UMR 5245, Laboratoire Écologie Fonctionnelle et Environnement, 118 route de Narbonne, 31062 Toulouse, France; Université de Toulouse, UPS, INP, Ecolab, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alewood</LastName><ForeName>Paul F</ForeName><Initials>PF</Initials><AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>King</LastName><ForeName>Glenn F</ForeName><Initials>GF</Initials><AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Orivel</LastName><ForeName>Jérôme</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>CNRS, UMR Ecologie des forêts de Guyane (AgroParisTech, CIRAD, CNRS, INRA, Université de Guyane, Université des Antilles), Campus Agronomique, BP 316, 97379 Kourou, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Escoubas</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>VenomeTech, 473 Route des Dolines, 06560 Valbonne, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>07</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Biochim Biophys Acta</MedlineTA><NlmUniqueID>0217513</NlmUniqueID><ISSNLinking>0006-3002</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000862">Ant Venoms</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004220">Disulfides</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D020816" MajorTopicYN="N">Amino Acid Motifs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000862" MajorTopicYN="N">Ant Venoms</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004220" MajorTopicYN="N">Disulfides</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Anochetus</Keyword><Keyword MajorTopicYN="Y">Ant venom</Keyword><Keyword MajorTopicYN="Y">Disulfide-rich peptides</Keyword><Keyword MajorTopicYN="Y">L-type calcium channels</Keyword><Keyword MajorTopicYN="Y">Neurotoxin</Keyword><Keyword MajorTopicYN="Y">Poneritoxins</Keyword><Keyword MajorTopicYN="Y">U(1)-PONTX-Ae1a</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>02</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>06</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>07</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27474999</ArticleId><ArticleId IdType="pii">S0304-4165(16)30274-4</ArticleId><ArticleId IdType="doi">10.1016/j.bbagen.2016.07.027</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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