Relation of Post-Coronary Artery Bypass Graft Creatine Kinase-MB Elevations and New Q Waves With Long-Term Cardiovascular Death in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease.
Identifieur interne : 001485 ( PubMed/Curation ); précédent : 001484; suivant : 001486Relation of Post-Coronary Artery Bypass Graft Creatine Kinase-MB Elevations and New Q Waves With Long-Term Cardiovascular Death in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease.
Auteurs : Michael Domanski [Canada] ; Michael E. Farkouh [Canada] ; Victor Zak [États-Unis] ; John French [Australie] ; John H. Alexander [États-Unis] ; Andrzej Bochenek [Pologne] ; Martial Hamon [France] ; Kenneth Mahaffey [États-Unis] ; John Puskas [France] ; Peter Smith [Géorgie (pays)] ; Peter Shrader [États-Unis] ; Valentin Fuster [Espagne]Source :
- The American journal of cardiology [ 1879-1913 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Cause de décès (tendances), Coronarographie, Diabète (mortalité), Diabète (sang), Europe (épidémiologie), Femelle, Humains, MB Creatine kinase (sang), Maladie des artères coronaires (), Maladie des artères coronaires (diagnostic), Maladie des artères coronaires (enzymologie), Maladie des artères coronaires (mortalité), Marqueurs biologiques (sang), Mâle, Nouvelle-Galles du Sud (épidémiologie), Ontario (épidémiologie), Pontage aortocoronarien, Pronostic, Période postopératoire, Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie (tendances), Vaisseaux coronaires (), Vaisseaux coronaires (imagerie diagnostique), Électrocardiographie, États-Unis d'Amérique (épidémiologie).
- MESH :
- diagnostic : Maladie des artères coronaires.
- enzymologie : Maladie des artères coronaires.
- imagerie diagnostique : Vaisseaux coronaires.
- mortalité : Diabète, Maladie des artères coronaires.
- sang : Diabète, MB Creatine kinase, Marqueurs biologiques.
- tendances : Cause de décès, Taux de survie.
- épidémiologie : Europe, Nouvelle-Galles du Sud, Ontario, États-Unis d'Amérique.
- Adulte, Adulte d'âge moyen, Coronarographie, Femelle, Humains, Maladie des artères coronaires, Mâle, Pontage aortocoronarien, Pronostic, Période postopératoire, Sujet âgé, Sujet âgé de 80 ans ou plus, Vaisseaux coronaires, Électrocardiographie.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Biomarkers (blood), Cause of Death (trends), Coronary Angiography, Coronary Artery Bypass, Coronary Artery Disease (diagnosis), Coronary Artery Disease (enzymology), Coronary Artery Disease (mortality), Coronary Artery Disease (surgery), Coronary Vessels (diagnostic imaging), Coronary Vessels (surgery), Creatine Kinase, MB Form (blood), Diabetes Mellitus (blood), Diabetes Mellitus (mortality), Electrocardiography, Europe (epidemiology), Female, Humans, Male, Middle Aged, New South Wales (epidemiology), Ontario (epidemiology), Postoperative Period, Prognosis, Survival Rate (trends), United States (epidemiology).
- MESH :
- chemical , blood : Biomarkers, Creatine Kinase, MB Form.
- blood : Diabetes Mellitus.
- diagnosis : Coronary Artery Disease.
- diagnostic imaging : Coronary Vessels.
- enzymology : Coronary Artery Disease.
- epidemiology : Europe, New South Wales, Ontario, United States.
- mortality : Coronary Artery Disease, Diabetes Mellitus.
- surgery : Coronary Artery Disease, Coronary Vessels.
- trends : Cause of Death, Survival Rate.
- Adult, Aged, Aged, 80 and over, Coronary Angiography, Coronary Artery Bypass, Electrocardiography, Female, Humans, Male, Middle Aged, Postoperative Period, Prognosis.
Abstract
Associations of early creatine phosphokinase-MB (CK-MB) elevation and new Q waves and their association with cardiovascular death (CVD) after coronary artery bypass grafting (CABG) have been reported, but this association has not been studied in a large population of patients with diabetes mellitus. In this study, we examine the association of periprocedural CK-MB elevations and new Q waves with CVD in the Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease trial. Cox proportional hazards regression was used to assess the relation of CK-MB elevations and new Q waves in the first 24 hours after procedure and their relation to CVD; logistic regression was used to assess odds ratios of these variables. Hazard ratios, 95% confidence intervals, and p values associated with Wald chi-square test are reported. CK-MB elevation in first 24 hours after procedure was independently associated with CVD. CVD hazard increased by 6% (p <0.001) with each multiple of CK-MB above the upper reference limit (URL); odds of new post-CABG Q waves increased by a factor of 1.08 (p <0.001); at 7× CK-MB URL, HR was >2. CK-MB URL multiples of 7, 12, and 15 were associated with new Q-wave odds ratios of 9, 16, and 27 times, respectively (p ≤0.001, C-statistic >0.70). New Q waves were independently associated with survival in the multivariate model only when CK-MB was excluded (p = 0.01). In conclusion, independent associations included (1) CVD and early post-CABG CK-MB elevation; (2) new Q waves with early post-CABG CK-MB elevation; (3) CVD with new Q waves only when CK-MB elevation is excluded from analysis.
DOI: 10.1016/j.amjcard.2016.08.041
PubMed: 27816118
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Biomarkers (blood)</term>
<term>Cause of Death (trends)</term>
<term>Coronary Angiography</term>
<term>Coronary Artery Bypass</term>
<term>Coronary Artery Disease (diagnosis)</term>
<term>Coronary Artery Disease (enzymology)</term>
<term>Coronary Artery Disease (mortality)</term>
<term>Coronary Artery Disease (surgery)</term>
<term>Coronary Vessels (diagnostic imaging)</term>
<term>Coronary Vessels (surgery)</term>
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<term>Cause de décès (tendances)</term>
<term>Coronarographie</term>
<term>Diabète (mortalité)</term>
<term>Diabète (sang)</term>
<term>Europe (épidémiologie)</term>
<term>Femelle</term>
<term>Humains</term>
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<term>Maladie des artères coronaires ()</term>
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<term>Maladie des artères coronaires (enzymologie)</term>
<term>Maladie des artères coronaires (mortalité)</term>
<term>Marqueurs biologiques (sang)</term>
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<term>Ontario (épidémiologie)</term>
<term>Pontage aortocoronarien</term>
<term>Pronostic</term>
<term>Période postopératoire</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
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<term>Aged</term>
<term>Aged, 80 and over</term>
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<term>Coronary Artery Bypass</term>
<term>Electrocardiography</term>
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<term>Maladie des artères coronaires</term>
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<front><div type="abstract" xml:lang="en">Associations of early creatine phosphokinase-MB (CK-MB) elevation and new Q waves and their association with cardiovascular death (CVD) after coronary artery bypass grafting (CABG) have been reported, but this association has not been studied in a large population of patients with diabetes mellitus. In this study, we examine the association of periprocedural CK-MB elevations and new Q waves with CVD in the Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease trial. Cox proportional hazards regression was used to assess the relation of CK-MB elevations and new Q waves in the first 24 hours after procedure and their relation to CVD; logistic regression was used to assess odds ratios of these variables. Hazard ratios, 95% confidence intervals, and p values associated with Wald chi-square test are reported. CK-MB elevation in first 24 hours after procedure was independently associated with CVD. CVD hazard increased by 6% (p <0.001) with each multiple of CK-MB above the upper reference limit (URL); odds of new post-CABG Q waves increased by a factor of 1.08 (p <0.001); at 7× CK-MB URL, HR was >2. CK-MB URL multiples of 7, 12, and 15 were associated with new Q-wave odds ratios of 9, 16, and 27 times, respectively (p ≤0.001, C-statistic >0.70). New Q waves were independently associated with survival in the multivariate model only when CK-MB was excluded (p = 0.01). In conclusion, independent associations included (1) CVD and early post-CABG CK-MB elevation; (2) new Q waves with early post-CABG CK-MB elevation; (3) CVD with new Q waves only when CK-MB elevation is excluded from analysis.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27816118</PMID>
<DateCreated><Year>2016</Year>
<Month>11</Month>
<Day>06</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>04</Month>
<Day>27</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>04</Month>
<Day>27</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1913</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>118</Volume>
<Issue>11</Issue>
<PubDate><Year>2016</Year>
<Month>Dec</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>The American journal of cardiology</Title>
<ISOAbbreviation>Am. J. Cardiol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Relation of Post-Coronary Artery Bypass Graft Creatine Kinase-MB Elevations and New Q Waves With Long-Term Cardiovascular Death in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease.</ArticleTitle>
<Pagination><MedlinePgn>1655-1660</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0002-9149(16)31432-1</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.amjcard.2016.08.041</ELocationID>
<Abstract><AbstractText>Associations of early creatine phosphokinase-MB (CK-MB) elevation and new Q waves and their association with cardiovascular death (CVD) after coronary artery bypass grafting (CABG) have been reported, but this association has not been studied in a large population of patients with diabetes mellitus. In this study, we examine the association of periprocedural CK-MB elevations and new Q waves with CVD in the Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease trial. Cox proportional hazards regression was used to assess the relation of CK-MB elevations and new Q waves in the first 24 hours after procedure and their relation to CVD; logistic regression was used to assess odds ratios of these variables. Hazard ratios, 95% confidence intervals, and p values associated with Wald chi-square test are reported. CK-MB elevation in first 24 hours after procedure was independently associated with CVD. CVD hazard increased by 6% (p <0.001) with each multiple of CK-MB above the upper reference limit (URL); odds of new post-CABG Q waves increased by a factor of 1.08 (p <0.001); at 7× CK-MB URL, HR was >2. CK-MB URL multiples of 7, 12, and 15 were associated with new Q-wave odds ratios of 9, 16, and 27 times, respectively (p ≤0.001, C-statistic >0.70). New Q waves were independently associated with survival in the multivariate model only when CK-MB was excluded (p = 0.01). In conclusion, independent associations included (1) CVD and early post-CABG CK-MB elevation; (2) new Q waves with early post-CABG CK-MB elevation; (3) CVD with new Q waves only when CK-MB elevation is excluded from analysis.</AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Domanski</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Peter Munk Cardiac Centre and the Heart and Stroke Richard Lewar Centre, University of Toronto, Toronto, Canada. Electronic address: michael.domanski@uhn.ca.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Farkouh</LastName>
<ForeName>Michael E</ForeName>
<Initials>ME</Initials>
<AffiliationInfo><Affiliation>Peter Munk Cardiac Centre and the Heart and Stroke Richard Lewar Centre, University of Toronto, Toronto, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zak</LastName>
<ForeName>Victor</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>The New England Research Institute, Watertown, Massachusetts.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>French</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Liverpool Hospital, University of New South Wales, Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alexander</LastName>
<ForeName>John H</ForeName>
<Initials>JH</Initials>
<AffiliationInfo><Affiliation>Duke Clinical Research Institute, Duke Medicine, Durham, North Carolina.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bochenek</LastName>
<ForeName>Andrzej</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Medical University of Silesia, Katowice, Poland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hamon</LastName>
<ForeName>Martial</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>CHU Caen, Caen, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mahaffey</LastName>
<ForeName>Kenneth</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Duke Clinical Research Institute, Duke Medicine, Durham, North Carolina.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Puskas</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>CHU Caen, Caen, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Smith</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Emory University Hospital Midtown, Atlanta, Georgia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shrader</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>The New England Research Institute, Watertown, Massachusetts.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fuster</LastName>
<ForeName>Valentin</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Icahn School of Medicine at Mount Sinai, New York, NY; Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>08</Month>
<Day>30</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Am J Cardiol</MedlineTA>
<NlmUniqueID>0207277</NlmUniqueID>
<ISSNLinking>0002-9149</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.3.2</RegistryNumber>
<NameOfSubstance UI="D052279">Creatine Kinase, MB Form</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002423" MajorTopicYN="N">Cause of Death</DescriptorName>
<QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017023" MajorTopicYN="N">Coronary Angiography</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001026" MajorTopicYN="Y">Coronary Artery Bypass</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003324" MajorTopicYN="N">Coronary Artery Disease</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003331" MajorTopicYN="N">Coronary Vessels</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName>
<QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D052279" MajorTopicYN="N">Creatine Kinase, MB Form</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003920" MajorTopicYN="N">Diabetes Mellitus</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004562" MajorTopicYN="Y">Electrocardiography</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005060" MajorTopicYN="N">Europe</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009517" MajorTopicYN="N">New South Wales</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009864" MajorTopicYN="N">Ontario</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011184" MajorTopicYN="N">Postoperative Period</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName>
<QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014481" MajorTopicYN="N">United States</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>04</Month>
<Day>25</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2016</Year>
<Month>08</Month>
<Day>19</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>08</Month>
<Day>19</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>11</Month>
<Day>7</Day>
<Hour>6</Hour>
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<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>4</Month>
<Day>28</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<ArticleId IdType="pii">S0002-9149(16)31432-1</ArticleId>
<ArticleId IdType="doi">10.1016/j.amjcard.2016.08.041</ArticleId>
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