Sclerostin does not play a major role in the pathogenesis of skeletal complications in type 2 diabetes mellitus.
Identifieur interne : 001361 ( PubMed/Curation ); précédent : 001360; suivant : 001362Sclerostin does not play a major role in the pathogenesis of skeletal complications in type 2 diabetes mellitus.
Auteurs : M. Pereira [Royaume-Uni] ; S. Gohin [Royaume-Uni] ; N. Lund [Royaume-Uni] ; A. Hvid [Royaume-Uni] ; P J Smitham [Royaume-Uni] ; M J Oddy [Royaume-Uni] ; I. Reichert [Royaume-Uni] ; D. Farlay [France] ; J P Roux [France] ; M E Cleasby [Royaume-Uni] ; C. Chenu [Royaume-Uni]Source :
- Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [ 1433-2965 ] ; 2017.
Abstract
In contrast to previously reported elevations in serum sclerostin levels in diabetic patients, the present study shows that the impaired bone microarchitecture and cellular turnover associated with type 2 diabetes mellitus (T2DM)-like conditions in ZDF rats are not correlated with changes in serum and bone sclerostin expression.
DOI: 10.1007/s00198-016-3718-0
PubMed: 27468901
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Pereira</name><affiliation wicri:level="1"><nlm:affiliation>Department of Comparative Biomedical sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU, UK. mpereira@rvc.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Comparative Biomedical sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU</wicri:regionArea></affiliation></author><author><name sortKey="Gohin, S" sort="Gohin, S" uniqKey="Gohin S" first="S" last="Gohin">S. Gohin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Comparative Biomedical sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Comparative Biomedical sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU</wicri:regionArea></affiliation></author><author><name sortKey="Lund, N" sort="Lund, N" uniqKey="Lund N" first="N" last="Lund">N. Lund</name><affiliation wicri:level="1"><nlm:affiliation>Department of Comparative Biomedical sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Comparative Biomedical sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU</wicri:regionArea></affiliation></author><author><name sortKey="Hvid, A" sort="Hvid, A" uniqKey="Hvid A" first="A" last="Hvid">A. Hvid</name><affiliation wicri:level="1"><nlm:affiliation>Department of Comparative Biomedical sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Comparative Biomedical sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU</wicri:regionArea></affiliation></author><author><name sortKey="Smitham, P J" sort="Smitham, P J" uniqKey="Smitham P" first="P J" last="Smitham">P J Smitham</name><affiliation wicri:level="1"><nlm:affiliation>University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Oddy, M J" sort="Oddy, M J" uniqKey="Oddy M" first="M J" last="Oddy">M J Oddy</name><affiliation wicri:level="1"><nlm:affiliation>University College Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Reichert, I" sort="Reichert, I" uniqKey="Reichert I" first="I" last="Reichert">I. Reichert</name><affiliation wicri:level="1"><nlm:affiliation>Kings College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Kings College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Farlay, D" sort="Farlay, D" uniqKey="Farlay D" first="D" last="Farlay">D. Farlay</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR1033 and Université de Lyon, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR1033 and Université de Lyon, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Roux, J P" sort="Roux, J P" uniqKey="Roux J" first="J P" last="Roux">J P Roux</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR1033 and Université de Lyon, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR1033 and Université de Lyon, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Cleasby, M E" sort="Cleasby, M E" uniqKey="Cleasby M" first="M E" last="Cleasby">M E Cleasby</name><affiliation wicri:level="1"><nlm:affiliation>Department of Comparative Biomedical sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Comparative Biomedical sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU</wicri:regionArea></affiliation></author><author><name sortKey="Chenu, C" sort="Chenu, C" uniqKey="Chenu C" first="C" last="Chenu">C. Chenu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Comparative Biomedical sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Comparative Biomedical sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU</wicri:regionArea></affiliation></author></analytic><series><title level="j">Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA</title><idno type="eISSN">1433-2965</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In contrast to previously reported elevations in serum sclerostin levels in diabetic patients, the present study shows that the impaired bone microarchitecture and cellular turnover associated with type 2 diabetes mellitus (T2DM)-like conditions in ZDF rats are not correlated with changes in serum and bone sclerostin expression.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27468901</PMID><DateCreated><Year>2016</Year><Month>07</Month><Day>29</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1433-2965</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA</Title><ISOAbbreviation>Osteoporos Int</ISOAbbreviation></Journal><ArticleTitle>Sclerostin does not play a major role in the pathogenesis of skeletal complications in type 2 diabetes mellitus.</ArticleTitle><Pagination><MedlinePgn>309-320</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00198-016-3718-0</ELocationID><Abstract><AbstractText>In contrast to previously reported elevations in serum sclerostin levels in diabetic patients, the present study shows that the impaired bone microarchitecture and cellular turnover associated with type 2 diabetes mellitus (T2DM)-like conditions in ZDF rats are not correlated with changes in serum and bone sclerostin expression.</AbstractText><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">T2DM is associated with impaired skeletal structure and a higher prevalence of bone fractures. Sclerostin, a negative regulator of bone formation, is elevated in serum of diabetic patients. We aimed to relate changes in bone architecture and cellular activities to sclerostin production in the Zucker diabetic fatty (ZDF) rat.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Bone density and architecture were measured by micro-CT and bone remodelling by histomorphometry in tibiae and femurs of 14-week-old male ZDF rats and lean Zucker controls (n = 6/group).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">ZDF rats showed lower trabecular bone mineral density and bone mass compared to controls, due to decreases in bone volume and thickness, along with impaired bone connectivity and cortical bone geometry. Bone remodelling was impaired in diabetic rats, demonstrated by decreased bone formation rate and increased percentage of tartrate-resistant acid phosphatase-positive osteoclastic surfaces. Serum sclerostin levels (ELISA) were higher in ZDF compared to lean rats at 9 weeks (+40 %, p < 0.01), but this difference disappeared as their glucose control deteriorated and by week 14, ZDF rats had lower sclerostin levels than control rats (-44 %, p < 0.0001). Bone sclerostin mRNA (qPCR) and protein (immunohistochemistry) were similar in ZDF, and lean rats at 14 weeks and genotype did not affect the number of empty osteocytic lacunae in cortical and trabecular bone.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">T2DM results in impaired skeletal architecture through altered remodelling pathways, but despite altered serum levels, it does not appear that sclerostin contributes to the deleterious effect of T2DM in rat bone.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pereira</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Comparative Biomedical sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU, UK. mpereira@rvc.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gohin</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Comparative Biomedical sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lund</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Comparative Biomedical sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hvid</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Comparative Biomedical sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smitham</LastName><ForeName>P J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>University College London, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The University of Adelaide, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oddy</LastName><ForeName>M J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>University College Hospital, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reichert</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Kings College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farlay</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>INSERM UMR1033 and Université de Lyon, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roux</LastName><ForeName>J P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>INSERM UMR1033 and Université de Lyon, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cleasby</LastName><ForeName>M E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>Department of Comparative Biomedical sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chenu</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Comparative Biomedical sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>07</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Osteoporos Int</MedlineTA><NlmUniqueID>9100105</NlmUniqueID><ISSNLinking>0937-941X</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Int J 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Version="1">12968669</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Bone</Keyword><Keyword MajorTopicYN="N">Sclerostin</Keyword><Keyword MajorTopicYN="N">Type 2 diabetes</Keyword><Keyword MajorTopicYN="N">Zucker rats</Keyword></KeywordList><CoiStatement>None.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>03</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>07</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27468901</ArticleId><ArticleId IdType="doi">10.1007/s00198-016-3718-0</ArticleId><ArticleId IdType="pii">10.1007/s00198-016-3718-0</ArticleId><ArticleId IdType="pmc">PMC5206261</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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