Effect of cardiac resynchronization therapy in patients with diabetes randomized in EchoCRT.
Identifieur interne : 001331 ( PubMed/Curation ); précédent : 001330; suivant : 001332Effect of cardiac resynchronization therapy in patients with diabetes randomized in EchoCRT.
Auteurs : Matthias P. N Gele [Suisse] ; Jan Steffel [Suisse] ; Michele Robertson [Royaume-Uni] ; Jagmeet P. Singh [États-Unis] ; Andreas J. Flammer [Suisse] ; Jeroen J. Bax [Pays-Bas] ; Jeffrey S. Borer [États-Unis] ; Kenneth Dickstein [Norvège] ; Ian Ford [Royaume-Uni] ; John Gorcsan [États-Unis] ; Daniel Gras [France] ; Henry Krum [Australie] ; Peter Sogaard [Danemark] ; Johannes Holzmeister [Suisse] ; William T. Abraham [États-Unis] ; Josep Brugada [Espagne] ; Frank Ruschitzka [Suisse]Source :
- European journal of heart failure [ 1879-0844 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- Aged, Arrhythmias, Cardiac (complications), Arrhythmias, Cardiac (therapy), Cardiac Resynchronization Therapy, Diabetes Complications, Diabetes Mellitus, Echocardiography, Female, Heart Failure (complications), Heart Failure (therapy), Hospitalization, Humans, Male, Middle Aged, Proportional Hazards Models.
- MESH :
Abstract
As patients with heart failure (HF) and concomitant diabetes carry a poor prognosis, this post-hoc subgroup analysis aimed to compare the outcomes of patients with and without diabetes randomized in the Echocardiography Guided Cardiac Resynchronization Therapy (EchoCRT) study.
DOI: 10.1002/ejhf.655
PubMed: 27862715
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N Gele</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, University Heart Centre Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Cardiology, University Heart Centre Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Steffel, Jan" sort="Steffel, Jan" uniqKey="Steffel J" first="Jan" last="Steffel">Jan Steffel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, University Heart Centre Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Cardiology, University Heart Centre Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Robertson, Michele" sort="Robertson, Michele" uniqKey="Robertson M" first="Michele" last="Robertson">Michele Robertson</name><affiliation wicri:level="1"><nlm:affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Robertson Centre for Biostatistics, University of Glasgow, Glasgow</wicri:regionArea></affiliation></author><author><name sortKey="Singh, Jagmeet P" sort="Singh, Jagmeet P" uniqKey="Singh J" first="Jagmeet P" last="Singh">Jagmeet P. 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N Gele</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, University Heart Centre Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Cardiology, University Heart Centre Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Steffel, Jan" sort="Steffel, Jan" uniqKey="Steffel J" first="Jan" last="Steffel">Jan Steffel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, University Heart Centre Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Cardiology, University Heart Centre Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Robertson, Michele" sort="Robertson, Michele" uniqKey="Robertson M" first="Michele" last="Robertson">Michele Robertson</name><affiliation wicri:level="1"><nlm:affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Robertson Centre for Biostatistics, University of Glasgow, Glasgow</wicri:regionArea></affiliation></author><author><name sortKey="Singh, Jagmeet P" sort="Singh, Jagmeet P" uniqKey="Singh J" first="Jagmeet P" last="Singh">Jagmeet P. Singh</name><affiliation wicri:level="1"><nlm:affiliation>Cardiac Arrhythmia Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiac Arrhythmia Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Flammer, Andreas J" sort="Flammer, Andreas J" uniqKey="Flammer A" first="Andreas J" last="Flammer">Andreas J. Flammer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, University Heart Centre Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Cardiology, University Heart Centre Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Bax, Jeroen J" sort="Bax, Jeroen J" uniqKey="Bax J" first="Jeroen J" last="Bax">Jeroen J. Bax</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Leiden University Medical Centre, Leiden, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Leiden University Medical Centre, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Borer, Jeffrey S" sort="Borer, Jeffrey S" uniqKey="Borer J" first="Jeffrey S" last="Borer">Jeffrey S. Borer</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cardiovascular Medicine and Howard Gilman and Ron and Jean Schiavone Institutes, State University of New York Downstate College of Medicine, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cardiovascular Medicine and Howard Gilman and Ron and Jean Schiavone Institutes, State University of New York Downstate College of Medicine, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Dickstein, Kenneth" sort="Dickstein, Kenneth" uniqKey="Dickstein K" first="Kenneth" last="Dickstein">Kenneth Dickstein</name><affiliation wicri:level="1"><nlm:affiliation>University of Bergen, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>University of Bergen, Bergen</wicri:regionArea></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation wicri:level="1"><nlm:affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Robertson Centre for Biostatistics, University of Glasgow, Glasgow</wicri:regionArea></affiliation></author><author><name sortKey="Gorcsan, John" sort="Gorcsan, John" uniqKey="Gorcsan J" first="John" last="Gorcsan">John Gorcsan</name><affiliation wicri:level="1"><nlm:affiliation>University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh, Pittsburgh, PA</wicri:regionArea></affiliation></author><author><name sortKey="Gras, Daniel" sort="Gras, Daniel" uniqKey="Gras D" first="Daniel" last="Gras">Daniel Gras</name><affiliation wicri:level="1"><nlm:affiliation>Nouvelles Cliniques Nantaises, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Nouvelles Cliniques Nantaises, Nantes</wicri:regionArea></affiliation></author><author><name sortKey="Krum, Henry" sort="Krum, Henry" uniqKey="Krum H" first="Henry" last="Krum">Henry Krum</name><affiliation wicri:level="1"><nlm:affiliation>Monash Centre of Cardiovascular Research and Education in Therapeutics, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash Centre of Cardiovascular Research and Education in Therapeutics, Melbourne, VIC</wicri:regionArea></affiliation></author><author><name sortKey="Sogaard, Peter" sort="Sogaard, Peter" uniqKey="Sogaard P" first="Peter" last="Sogaard">Peter Sogaard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology and Clinical Institute, Aalborg University Hospital, Aalborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Cardiology and Clinical Institute, Aalborg University Hospital, Aalborg</wicri:regionArea></affiliation></author><author><name sortKey="Holzmeister, Johannes" sort="Holzmeister, Johannes" uniqKey="Holzmeister J" first="Johannes" last="Holzmeister">Johannes Holzmeister</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, University Heart Centre Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Cardiology, University Heart Centre Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Abraham, William T" sort="Abraham, William T" uniqKey="Abraham W" first="William T" last="Abraham">William T. Abraham</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cardiovascular Medicine, Ohio State University Medical Center, Columbus, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cardiovascular Medicine, Ohio State University Medical Center, Columbus, OH</wicri:regionArea></affiliation></author><author><name sortKey="Brugada, Josep" sort="Brugada, Josep" uniqKey="Brugada J" first="Josep" last="Brugada">Josep Brugada</name><affiliation wicri:level="1"><nlm:affiliation>Cardiology Department, Thorax Institute, Hospital Clinic, University of Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cardiology Department, Thorax Institute, Hospital Clinic, University of Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Ruschitzka, Frank" sort="Ruschitzka, Frank" uniqKey="Ruschitzka F" first="Frank" last="Ruschitzka">Frank Ruschitzka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, University Heart Centre Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Cardiology, University Heart Centre Zurich, Zurich</wicri:regionArea></affiliation></author></analytic><series><title level="j">European journal of heart failure</title><idno type="eISSN">1879-0844</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Arrhythmias, Cardiac (complications)</term><term>Arrhythmias, Cardiac (therapy)</term><term>Cardiac Resynchronization Therapy</term><term>Diabetes Complications</term><term>Diabetes Mellitus</term><term>Echocardiography</term><term>Female</term><term>Heart Failure (complications)</term><term>Heart Failure (therapy)</term><term>Hospitalization</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Proportional Hazards Models</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Complications du diabète</term><term>Diabète</term><term>Défaillance cardiaque ()</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Modèles de hasards proportionnels</term><term>Mâle</term><term>Sujet âgé</term><term>Thérapie de resynchronisation cardiaque</term><term>Troubles du rythme cardiaque ()</term><term>Échocardiographie</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Arrhythmias, Cardiac</term><term>Heart Failure</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Arrhythmias, Cardiac</term><term>Heart Failure</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cardiac Resynchronization Therapy</term><term>Diabetes Complications</term><term>Diabetes Mellitus</term><term>Echocardiography</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Proportional Hazards Models</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Complications du diabète</term><term>Diabète</term><term>Défaillance cardiaque</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Modèles de hasards proportionnels</term><term>Mâle</term><term>Sujet âgé</term><term>Thérapie de resynchronisation cardiaque</term><term>Troubles du rythme cardiaque</term><term>Échocardiographie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">As patients with heart failure (HF) and concomitant diabetes carry a poor prognosis, this post-hoc subgroup analysis aimed to compare the outcomes of patients with and without diabetes randomized in the Echocardiography Guided Cardiac Resynchronization Therapy (EchoCRT) study.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27862715</PMID><DateCreated><Year>2016</Year><Month>11</Month><Day>18</Day></DateCreated><DateCompleted><Year>2017</Year><Month>11</Month><Day>09</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0844</ISSN><JournalIssue CitedMedium="Internet"><Volume>19</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Jan</Month></PubDate></JournalIssue><Title>European journal of heart failure</Title><ISOAbbreviation>Eur. J. Heart Fail.</ISOAbbreviation></Journal><ArticleTitle>Effect of cardiac resynchronization therapy in patients with diabetes randomized in EchoCRT.</ArticleTitle><Pagination><MedlinePgn>80-87</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/ejhf.655</ELocationID><Abstract><AbstractText Label="AIMS" NlmCategory="OBJECTIVE">As patients with heart failure (HF) and concomitant diabetes carry a poor prognosis, this post-hoc subgroup analysis aimed to compare the outcomes of patients with and without diabetes randomized in the Echocardiography Guided Cardiac Resynchronization Therapy (EchoCRT) study.</AbstractText><AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">EchoCRT randomized patients with a QRS duration <130 ms and echocardiographic evidence of left ventricular dyssynchrony to CRT turned on (CRT=ON) vs. off (CRT=OFF) following device implantation. At study entry, 328 patients (40.5%) had diabetes. The primary outcome (all-cause death or first hospitalization for worsening HF) occurred more frequently in patients with than without diabetes (32.6% vs. 23%, P = 0.003). A significant treatment interaction was observed for the primary outcome indicating a higher risk for CRT=ON vs. CRT-OFF in patients without [26.5% vs. 19.8%, hazard ratio (HR) 1.58, 95% confidence interval (CI) 1.08-2.31] vs. with diabetes (31.4% vs. 34%; HR 0.86, 95% CI 0.58-1.27; P for interaction 0.041). This effect was mainly driven by a lower rate in HF hospitalizations, but was only of borderline significance after multivariate adjustment (P = 0.063). The most pronounced effect was observed in patients with non-ischaemic cardiomyopathy, where a significantly reduced risk of reaching the primary endpoint for CRT=ON vs. CRT-OFF was observed in patients with (HR 0.27, P = 0.003) vs. patients without diabetes (HR 1.79, P = 0.038; P for interaction 0.005). No treatment interaction by diabetes diagnosis was found for mortality endpoints.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In EchoCRT, HF patients with a narrow QRS complex and coexisting diabetes demonstrated a signal for less harm caused by CRT compared with patients without diabetes, which was driven by differences in hospitalizations owing to HF.</AbstractText><CopyrightInformation>© 2016 The Authors. European Journal of Heart Failure © 2016 European Society of Cardiology.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nägele</LastName><ForeName>Matthias P</ForeName><Initials>MP</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University Heart Centre Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Steffel</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University Heart Centre Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robertson</LastName><ForeName>Michele</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singh</LastName><ForeName>Jagmeet P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Cardiac Arrhythmia Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Flammer</LastName><ForeName>Andreas J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University Heart Centre Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bax</LastName><ForeName>Jeroen J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Leiden University Medical Centre, Leiden, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borer</LastName><ForeName>Jeffrey S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine and Howard Gilman and Ron and Jean Schiavone Institutes, State University of New York Downstate College of Medicine, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dickstein</LastName><ForeName>Kenneth</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>University of Bergen, Bergen, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Stavanger University Hospital, Stavanger, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ford</LastName><ForeName>Ian</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gorcsan</LastName><ForeName>John</ForeName><Initials>J</Initials><Suffix>3rd</Suffix><AffiliationInfo><Affiliation>University of Pittsburgh, Pittsburgh, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gras</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Nouvelles Cliniques Nantaises, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krum</LastName><ForeName>Henry</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Monash Centre of Cardiovascular Research and Education in Therapeutics, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sogaard</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Cardiology and Clinical Institute, Aalborg University Hospital, Aalborg, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holzmeister</LastName><ForeName>Johannes</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University Heart Centre Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abraham</LastName><ForeName>William T</ForeName><Initials>WT</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Ohio State University Medical Center, Columbus, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brugada</LastName><ForeName>Josep</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Cardiology Department, Thorax Institute, Hospital Clinic, University of Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruschitzka</LastName><ForeName>Frank</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University Heart Centre Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>11</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Eur J Heart Fail</MedlineTA><NlmUniqueID>100887595</NlmUniqueID><ISSNLinking>1388-9842</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001145" MajorTopicYN="N">Arrhythmias, Cardiac</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058406" MajorTopicYN="Y">Cardiac Resynchronization Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D048909" MajorTopicYN="Y">Diabetes Complications</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003920" MajorTopicYN="Y">Diabetes Mellitus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004452" MajorTopicYN="N">Echocardiography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006333" MajorTopicYN="N">Heart Failure</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016016" MajorTopicYN="N">Proportional Hazards Models</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cardiac resynchronization therapy</Keyword><Keyword MajorTopicYN="N">Diabetes</Keyword><Keyword MajorTopicYN="N">Heart failure</Keyword><Keyword MajorTopicYN="N">Narrow QRS</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>05</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>06</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>08</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>11</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27862715</ArticleId><ArticleId IdType="doi">10.1002/ejhf.655</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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