AustralieFrV1, PubMed, Curation, bibRecord, 001329

High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.

Identifieur interne : 001329 ( PubMed/Curation ); précédent : 001328; suivant : 001330

High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.

Auteurs : Emiel P C. Van Der Vorst [Allemagne] ; Kosta Theodorou [Pays-Bas] ; Yongzheng Wu [France] ; Marten A. Hoeksema [Pays-Bas] ; Pieter Goossens [France] ; Christina A. Bursill [Australie] ; Taghi Aliyev [Pays-Bas] ; Leonie F A. Huitema [Pays-Bas] ; Sander W. Tas [Pays-Bas] ; Ine M J. Wolfs [Pays-Bas] ; Marijke J E. Kuijpers [Pays-Bas] ; Marion J. Gijbels [Pays-Bas] ; Casper G. Schalkwijk [Pays-Bas] ; Debby P Y. Koonen [Pays-Bas] ; Shahla Abdollahi-Roodsaz [Pays-Bas] ; Kimberly Mcdaniels [États-Unis] ; Chih-Chieh Wang [États-Unis] ; Michael Leitges [Norvège] ; Toby Lawrence [France] ; Jogchum Plat [Pays-Bas] ; Miranda Van Eck [Pays-Bas] ; Kerry-Anne Rye [Australie] ; Lhousseine Touqui [France] ; Menno P J. De Winther [Pays-Bas] ; Erik A L. Biessen [Allemagne] ; Marjo M P C. Donners [Pays-Bas]

Source :

Cell metabolism [ 1932-7420 ] ; 2017.

RBID : pubmed:27866837

Descripteurs français

English descriptors

KwdEn :
- Animals, Base Sequence, Biological Transport (drug effects), Cells, Cultured, Cholesterol (metabolism), Humans, Inflammation (metabolism), Inflammation (pathology), Interferon Regulatory Factor-1 (metabolism), Lipoproteins, HDL (pharmacology), Macrophages (metabolism), Macrophages (pathology), Membrane Microdomains (drug effects), Membrane Microdomains (metabolism), Mice, Mice, Inbred C57BL, Models, Biological, NF-kappa B (metabolism), Protein Kinase C (metabolism), Respiratory Tract Infections (metabolism), Respiratory Tract Infections (microbiology), Respiratory Tract Infections (pathology), STAT1 Transcription Factor (metabolism), Signal Transduction (drug effects), Toll-Like Receptors (metabolism).
MESH :
- chemical , metabolism : Cholesterol, Interferon Regulatory Factor-1, NF-kappa B, Protein Kinase C, STAT1 Transcription Factor, Toll-Like Receptors.
- drug effects : Biological Transport, Membrane Microdomains, Signal Transduction.
- metabolism : Inflammation, Macrophages, Membrane Microdomains, Respiratory Tract Infections.
- microbiology : Respiratory Tract Infections.
- pathology : Inflammation, Macrophages, Respiratory Tract Infections.
- chemical , pharmacology : Lipoproteins, HDL.
- Animals, Base Sequence, Cells, Cultured, Humans, Mice, Mice, Inbred C57BL, Models, Biological.

Abstract

Membrane cholesterol modulates a variety of cell signaling pathways and functions. While cholesterol depletion by high-density lipoproteins (HDLs) has potent anti-inflammatory effects in various cell types, its effects on inflammatory responses in macrophages remain elusive. Here we show overt pro-inflammatory effects of HDL-mediated passive cholesterol depletion and lipid raft disruption in murine and human primary macrophages in vitro. These pro-inflammatory effects were confirmed in vivo in peritoneal macrophages from apoA-I transgenic mice, which have elevated HDL levels. In line with these findings, the innate immune responses required for clearance of P. aeruginosa bacterial infection in lung were compromised in mice with low HDL levels. Expression analysis, ChIP-PCR, and combinatorial pharmacological and genetic intervention studies unveiled that both native and reconstituted HDL enhance Toll-like-receptor-induced signaling by activating a PKC-NF-κB/STAT1-IRF1 axis, leading to increased inflammatory cytokine expression. HDL's pro-inflammatory activity supports proper functioning of macrophage immune responses.

DOI: 10.1016/j.cmet.2016.10.013
PubMed: 27866837

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Le document en format XML

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<author><name sortKey="Van Der Vorst, Emiel P C" sort="Van Der Vorst, Emiel P C" uniqKey="Van Der Vorst E" first="Emiel P C" last="Van Der Vorst">Emiel P C. Van Der Vorst</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, 80336 Munich, Germany. Electronic address: e.vandervorst@maastrichtuniversity.nl.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, 80336 Munich</wicri:regionArea>
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<author><name sortKey="Theodorou, Kosta" sort="Theodorou, Kosta" uniqKey="Theodorou K" first="Kosta" last="Theodorou">Kosta Theodorou</name>
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<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
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<author><name sortKey="Wu, Yongzheng" sort="Wu, Yongzheng" uniqKey="Wu Y" first="Yongzheng" last="Wu">Yongzheng Wu</name>
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<author><name sortKey="Hoeksema, Marten A" sort="Hoeksema, Marten A" uniqKey="Hoeksema M" first="Marten A" last="Hoeksema">Marten A. Hoeksema</name>
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<author><name sortKey="Goossens, Pieter" sort="Goossens, Pieter" uniqKey="Goossens P" first="Pieter" last="Goossens">Pieter Goossens</name>
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<author><name sortKey="Bursill, Christina A" sort="Bursill, Christina A" uniqKey="Bursill C" first="Christina A" last="Bursill">Christina A. Bursill</name>
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<author><name sortKey="Aliyev, Taghi" sort="Aliyev, Taghi" uniqKey="Aliyev T" first="Taghi" last="Aliyev">Taghi Aliyev</name>
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<author><name sortKey="Huitema, Leonie F A" sort="Huitema, Leonie F A" uniqKey="Huitema L" first="Leonie F A" last="Huitema">Leonie F A. Huitema</name>
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<author><name sortKey="Tas, Sander W" sort="Tas, Sander W" uniqKey="Tas S" first="Sander W" last="Tas">Sander W. Tas</name>
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<author><name sortKey="Wolfs, Ine M J" sort="Wolfs, Ine M J" uniqKey="Wolfs I" first="Ine M J" last="Wolfs">Ine M J. Wolfs</name>
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<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
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</affiliation>
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<author><name sortKey="Kuijpers, Marijke J E" sort="Kuijpers, Marijke J E" uniqKey="Kuijpers M" first="Marijke J E" last="Kuijpers">Marijke J E. Kuijpers</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Biochemistry, CARIM, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
</affiliation>
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<author><name sortKey="Gijbels, Marion J" sort="Gijbels, Marion J" uniqKey="Gijbels M" first="Marion J" last="Gijbels">Marion J. Gijbels</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schalkwijk, Casper G" sort="Schalkwijk, Casper G" uniqKey="Schalkwijk C" first="Casper G" last="Schalkwijk">Casper G. Schalkwijk</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, CARIM, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koonen, Debby P Y" sort="Koonen, Debby P Y" uniqKey="Koonen D" first="Debby P Y" last="Koonen">Debby P Y. Koonen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Abdollahi Roodsaz, Shahla" sort="Abdollahi Roodsaz, Shahla" uniqKey="Abdollahi Roodsaz S" first="Shahla" last="Abdollahi-Roodsaz">Shahla Abdollahi-Roodsaz</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Rheumatology, Radboud University Nijmegen Medical Center, 6525 GA Nijmegen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Experimental Rheumatology, Radboud University Nijmegen Medical Center, 6525 GA Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcdaniels, Kimberly" sort="Mcdaniels, Kimberly" uniqKey="Mcdaniels K" first="Kimberly" last="Mcdaniels">Kimberly Mcdaniels</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurobiology, Harvard Medical School, Boston, MA 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Chih Chieh" sort="Wang, Chih Chieh" uniqKey="Wang C" first="Chih-Chieh" last="Wang">Chih-Chieh Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurobiology, Harvard Medical School, Boston, MA 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Leitges, Michael" sort="Leitges, Michael" uniqKey="Leitges M" first="Michael" last="Leitges">Michael Leitges</name>
<affiliation wicri:level="1"><nlm:affiliation>Biotechnology Centre of Oslo, University of Oslo, 0313 Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Biotechnology Centre of Oslo, University of Oslo, 0313 Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lawrence, Toby" sort="Lawrence, Toby" uniqKey="Lawrence T" first="Toby" last="Lawrence">Toby Lawrence</name>
<affiliation wicri:level="1"><nlm:affiliation>Inflammation Biology Group, Centre d'Immunologie Marseille-Luminy, 13288 Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inflammation Biology Group, Centre d'Immunologie Marseille-Luminy, 13288 Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Plat, Jogchum" sort="Plat, Jogchum" uniqKey="Plat J" first="Jogchum" last="Plat">Jogchum Plat</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Human Biology, Nutrim, Maastricht University, 6200 MD Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Human Biology, Nutrim, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Eck, Miranda" sort="Van Eck, Miranda" uniqKey="Van Eck M" first="Miranda" last="Van Eck">Miranda Van Eck</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Biopharmaceutics, Leiden Academic Center for Drug Research, Leiden University, 2333 CC Leiden, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Division of Biopharmaceutics, Leiden Academic Center for Drug Research, Leiden University, 2333 CC Leiden</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name>
<affiliation wicri:level="1"><nlm:affiliation>Heart Research Institute, 2050 Newtown, Australia; Sydney Medical School, University of Sydney, 2006 Sydney, Australia; Centre for Vascular Research, University of New South Wales, 2052 Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Heart Research Institute, 2050 Newtown, Australia; Sydney Medical School, University of Sydney, 2006 Sydney, Australia; Centre for Vascular Research, University of New South Wales, 2052 Sydney</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Touqui, Lhousseine" sort="Touqui, Lhousseine" uniqKey="Touqui L" first="Lhousseine" last="Touqui">Lhousseine Touqui</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infection & Epidemiology, Institut Pasteur, 75015 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Infection & Epidemiology, Institut Pasteur, 75015 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Winther, Menno P J" sort="De Winther, Menno P J" uniqKey="De Winther M" first="Menno P J" last="De Winther">Menno P J. De Winther</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Biessen, Erik A L" sort="Biessen, Erik A L" uniqKey="Biessen E" first="Erik A L" last="Biessen">Erik A L. Biessen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; IMCARIM, Uniklinikum Aachen, 52074 Aachen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; IMCARIM, Uniklinikum Aachen, 52074 Aachen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Donners, Marjo M P C" sort="Donners, Marjo M P C" uniqKey="Donners M" first="Marjo M P C" last="Donners">Marjo M P C. Donners</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands. Electronic address: marjo.donners@maastrichtuniversity.nl.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.</title>
<author><name sortKey="Van Der Vorst, Emiel P C" sort="Van Der Vorst, Emiel P C" uniqKey="Van Der Vorst E" first="Emiel P C" last="Van Der Vorst">Emiel P C. Van Der Vorst</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, 80336 Munich, Germany. Electronic address: e.vandervorst@maastrichtuniversity.nl.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, 80336 Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Theodorou, Kosta" sort="Theodorou, Kosta" uniqKey="Theodorou K" first="Kosta" last="Theodorou">Kosta Theodorou</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wu, Yongzheng" sort="Wu, Yongzheng" uniqKey="Wu Y" first="Yongzheng" last="Wu">Yongzheng Wu</name>
<affiliation wicri:level="1"><nlm:affiliation>Unit of Cellular Biology of Microbial Infection, CNRS UMR3691, Institut Pasteur, 75015 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unit of Cellular Biology of Microbial Infection, CNRS UMR3691, Institut Pasteur, 75015 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hoeksema, Marten A" sort="Hoeksema, Marten A" uniqKey="Hoeksema M" first="Marten A" last="Hoeksema">Marten A. Hoeksema</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Goossens, Pieter" sort="Goossens, Pieter" uniqKey="Goossens P" first="Pieter" last="Goossens">Pieter Goossens</name>
<affiliation wicri:level="1"><nlm:affiliation>Inflammation Biology Group, Centre d'Immunologie Marseille-Luminy, 13288 Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inflammation Biology Group, Centre d'Immunologie Marseille-Luminy, 13288 Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bursill, Christina A" sort="Bursill, Christina A" uniqKey="Bursill C" first="Christina A" last="Bursill">Christina A. Bursill</name>
<affiliation wicri:level="1"><nlm:affiliation>Heart Research Institute, 2050 Newtown, Australia; Sydney Medical School, University of Sydney, 2006 Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Heart Research Institute, 2050 Newtown, Australia; Sydney Medical School, University of Sydney, 2006 Sydney</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aliyev, Taghi" sort="Aliyev, Taghi" uniqKey="Aliyev T" first="Taghi" last="Aliyev">Taghi Aliyev</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huitema, Leonie F A" sort="Huitema, Leonie F A" uniqKey="Huitema L" first="Leonie F A" last="Huitema">Leonie F A. Huitema</name>
<affiliation wicri:level="1"><nlm:affiliation>Amsterdam Rheumatology and Immunology Center, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Amsterdam Rheumatology and Immunology Center, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tas, Sander W" sort="Tas, Sander W" uniqKey="Tas S" first="Sander W" last="Tas">Sander W. Tas</name>
<affiliation wicri:level="1"><nlm:affiliation>Amsterdam Rheumatology and Immunology Center, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Amsterdam Rheumatology and Immunology Center, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wolfs, Ine M J" sort="Wolfs, Ine M J" uniqKey="Wolfs I" first="Ine M J" last="Wolfs">Ine M J. Wolfs</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kuijpers, Marijke J E" sort="Kuijpers, Marijke J E" uniqKey="Kuijpers M" first="Marijke J E" last="Kuijpers">Marijke J E. Kuijpers</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Biochemistry, CARIM, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gijbels, Marion J" sort="Gijbels, Marion J" uniqKey="Gijbels M" first="Marion J" last="Gijbels">Marion J. Gijbels</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schalkwijk, Casper G" sort="Schalkwijk, Casper G" uniqKey="Schalkwijk C" first="Casper G" last="Schalkwijk">Casper G. Schalkwijk</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, CARIM, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koonen, Debby P Y" sort="Koonen, Debby P Y" uniqKey="Koonen D" first="Debby P Y" last="Koonen">Debby P Y. Koonen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Abdollahi Roodsaz, Shahla" sort="Abdollahi Roodsaz, Shahla" uniqKey="Abdollahi Roodsaz S" first="Shahla" last="Abdollahi-Roodsaz">Shahla Abdollahi-Roodsaz</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Rheumatology, Radboud University Nijmegen Medical Center, 6525 GA Nijmegen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Experimental Rheumatology, Radboud University Nijmegen Medical Center, 6525 GA Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcdaniels, Kimberly" sort="Mcdaniels, Kimberly" uniqKey="Mcdaniels K" first="Kimberly" last="Mcdaniels">Kimberly Mcdaniels</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurobiology, Harvard Medical School, Boston, MA 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Chih Chieh" sort="Wang, Chih Chieh" uniqKey="Wang C" first="Chih-Chieh" last="Wang">Chih-Chieh Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurobiology, Harvard Medical School, Boston, MA 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Leitges, Michael" sort="Leitges, Michael" uniqKey="Leitges M" first="Michael" last="Leitges">Michael Leitges</name>
<affiliation wicri:level="1"><nlm:affiliation>Biotechnology Centre of Oslo, University of Oslo, 0313 Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Biotechnology Centre of Oslo, University of Oslo, 0313 Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lawrence, Toby" sort="Lawrence, Toby" uniqKey="Lawrence T" first="Toby" last="Lawrence">Toby Lawrence</name>
<affiliation wicri:level="1"><nlm:affiliation>Inflammation Biology Group, Centre d'Immunologie Marseille-Luminy, 13288 Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inflammation Biology Group, Centre d'Immunologie Marseille-Luminy, 13288 Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Plat, Jogchum" sort="Plat, Jogchum" uniqKey="Plat J" first="Jogchum" last="Plat">Jogchum Plat</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Human Biology, Nutrim, Maastricht University, 6200 MD Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Human Biology, Nutrim, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Eck, Miranda" sort="Van Eck, Miranda" uniqKey="Van Eck M" first="Miranda" last="Van Eck">Miranda Van Eck</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Biopharmaceutics, Leiden Academic Center for Drug Research, Leiden University, 2333 CC Leiden, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Division of Biopharmaceutics, Leiden Academic Center for Drug Research, Leiden University, 2333 CC Leiden</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name>
<affiliation wicri:level="1"><nlm:affiliation>Heart Research Institute, 2050 Newtown, Australia; Sydney Medical School, University of Sydney, 2006 Sydney, Australia; Centre for Vascular Research, University of New South Wales, 2052 Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Heart Research Institute, 2050 Newtown, Australia; Sydney Medical School, University of Sydney, 2006 Sydney, Australia; Centre for Vascular Research, University of New South Wales, 2052 Sydney</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Touqui, Lhousseine" sort="Touqui, Lhousseine" uniqKey="Touqui L" first="Lhousseine" last="Touqui">Lhousseine Touqui</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infection & Epidemiology, Institut Pasteur, 75015 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Infection & Epidemiology, Institut Pasteur, 75015 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Winther, Menno P J" sort="De Winther, Menno P J" uniqKey="De Winther M" first="Menno P J" last="De Winther">Menno P J. De Winther</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Biessen, Erik A L" sort="Biessen, Erik A L" uniqKey="Biessen E" first="Erik A L" last="Biessen">Erik A L. Biessen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; IMCARIM, Uniklinikum Aachen, 52074 Aachen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; IMCARIM, Uniklinikum Aachen, 52074 Aachen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Donners, Marjo M P C" sort="Donners, Marjo M P C" uniqKey="Donners M" first="Marjo M P C" last="Donners">Marjo M P C. Donners</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands. Electronic address: marjo.donners@maastrichtuniversity.nl.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell metabolism</title>
<idno type="eISSN">1932-7420</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
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<term>Base Sequence</term>
<term>Biological Transport (drug effects)</term>
<term>Cells, Cultured</term>
<term>Cholesterol (metabolism)</term>
<term>Humans</term>
<term>Inflammation (metabolism)</term>
<term>Inflammation (pathology)</term>
<term>Interferon Regulatory Factor-1 (metabolism)</term>
<term>Lipoproteins, HDL (pharmacology)</term>
<term>Macrophages (metabolism)</term>
<term>Macrophages (pathology)</term>
<term>Membrane Microdomains (drug effects)</term>
<term>Membrane Microdomains (metabolism)</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Models, Biological</term>
<term>NF-kappa B (metabolism)</term>
<term>Protein Kinase C (metabolism)</term>
<term>Respiratory Tract Infections (metabolism)</term>
<term>Respiratory Tract Infections (microbiology)</term>
<term>Respiratory Tract Infections (pathology)</term>
<term>STAT1 Transcription Factor (metabolism)</term>
<term>Signal Transduction (drug effects)</term>
<term>Toll-Like Receptors (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Cholestérol (métabolisme)</term>
<term>Facteur de transcription NF-kappa B (métabolisme)</term>
<term>Facteur de transcription STAT-1 (métabolisme)</term>
<term>Facteur-1 de régulation d'interféron (métabolisme)</term>
<term>Humains</term>
<term>Infections de l'appareil respiratoire (anatomopathologie)</term>
<term>Infections de l'appareil respiratoire (microbiologie)</term>
<term>Infections de l'appareil respiratoire (métabolisme)</term>
<term>Inflammation (anatomopathologie)</term>
<term>Inflammation (métabolisme)</term>
<term>Lipoprotéines HDL (pharmacologie)</term>
<term>Macrophages (anatomopathologie)</term>
<term>Macrophages (métabolisme)</term>
<term>Microdomaines membranaires ()</term>
<term>Microdomaines membranaires (métabolisme)</term>
<term>Modèles biologiques</term>
<term>Protéine kinase C (métabolisme)</term>
<term>Récepteurs de type Toll (métabolisme)</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Séquence nucléotidique</term>
<term>Transduction du signal ()</term>
<term>Transport biologique ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cholesterol</term>
<term>Interferon Regulatory Factor-1</term>
<term>NF-kappa B</term>
<term>Protein Kinase C</term>
<term>STAT1 Transcription Factor</term>
<term>Toll-Like Receptors</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term>
<term>Inflammation</term>
<term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Biological Transport</term>
<term>Membrane Microdomains</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Inflammation</term>
<term>Macrophages</term>
<term>Membrane Microdomains</term>
<term>Respiratory Tract Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Respiratory Tract Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cholestérol</term>
<term>Facteur de transcription NF-kappa B</term>
<term>Facteur de transcription STAT-1</term>
<term>Facteur-1 de régulation d'interféron</term>
<term>Infections de l'appareil respiratoire</term>
<term>Inflammation</term>
<term>Macrophages</term>
<term>Microdomaines membranaires</term>
<term>Protéine kinase C</term>
<term>Récepteurs de type Toll</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Inflammation</term>
<term>Macrophages</term>
<term>Respiratory Tract Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Lipoprotéines HDL</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Lipoproteins, HDL</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Base Sequence</term>
<term>Cells, Cultured</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Models, Biological</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Humains</term>
<term>Microdomaines membranaires</term>
<term>Modèles biologiques</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Séquence nucléotidique</term>
<term>Transduction du signal</term>
<term>Transport biologique</term>
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<front><div type="abstract" xml:lang="en">Membrane cholesterol modulates a variety of cell signaling pathways and functions. While cholesterol depletion by high-density lipoproteins (HDLs) has potent anti-inflammatory effects in various cell types, its effects on inflammatory responses in macrophages remain elusive. Here we show overt pro-inflammatory effects of HDL-mediated passive cholesterol depletion and lipid raft disruption in murine and human primary macrophages in vitro. These pro-inflammatory effects were confirmed in vivo in peritoneal macrophages from apoA-I transgenic mice, which have elevated HDL levels. In line with these findings, the innate immune responses required for clearance of P. aeruginosa bacterial infection in lung were compromised in mice with low HDL levels. Expression analysis, ChIP-PCR, and combinatorial pharmacological and genetic intervention studies unveiled that both native and reconstituted HDL enhance Toll-like-receptor-induced signaling by activating a PKC-NF-κB/STAT1-IRF1 axis, leading to increased inflammatory cytokine expression. HDL's pro-inflammatory activity supports proper functioning of macrophage immune responses.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27866837</PMID>
<DateCreated><Year>2016</Year>
<Month>11</Month>
<Day>21</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>07</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>03</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1932-7420</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>25</Volume>
<Issue>1</Issue>
<PubDate><Year>2017</Year>
<Month>Jan</Month>
<Day>10</Day>
</PubDate>
</JournalIssue>
<Title>Cell metabolism</Title>
<ISOAbbreviation>Cell Metab.</ISOAbbreviation>
</Journal>
<ArticleTitle>High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.</ArticleTitle>
<Pagination><MedlinePgn>197-207</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S1550-4131(16)30544-7</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cmet.2016.10.013</ELocationID>
<Abstract><AbstractText>Membrane cholesterol modulates a variety of cell signaling pathways and functions. While cholesterol depletion by high-density lipoproteins (HDLs) has potent anti-inflammatory effects in various cell types, its effects on inflammatory responses in macrophages remain elusive. Here we show overt pro-inflammatory effects of HDL-mediated passive cholesterol depletion and lipid raft disruption in murine and human primary macrophages in vitro. These pro-inflammatory effects were confirmed in vivo in peritoneal macrophages from apoA-I transgenic mice, which have elevated HDL levels. In line with these findings, the innate immune responses required for clearance of P. aeruginosa bacterial infection in lung were compromised in mice with low HDL levels. Expression analysis, ChIP-PCR, and combinatorial pharmacological and genetic intervention studies unveiled that both native and reconstituted HDL enhance Toll-like-receptor-induced signaling by activating a PKC-NF-κB/STAT1-IRF1 axis, leading to increased inflammatory cytokine expression. HDL's pro-inflammatory activity supports proper functioning of macrophage immune responses.</AbstractText>
<CopyrightInformation>Copyright © 2017 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>van der Vorst</LastName>
<ForeName>Emiel P C</ForeName>
<Initials>EPC</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, 80336 Munich, Germany. Electronic address: e.vandervorst@maastrichtuniversity.nl.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Theodorou</LastName>
<ForeName>Kosta</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Yongzheng</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Unit of Cellular Biology of Microbial Infection, CNRS UMR3691, Institut Pasteur, 75015 Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hoeksema</LastName>
<ForeName>Marten A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Goossens</LastName>
<ForeName>Pieter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Inflammation Biology Group, Centre d'Immunologie Marseille-Luminy, 13288 Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bursill</LastName>
<ForeName>Christina A</ForeName>
<Initials>CA</Initials>
<AffiliationInfo><Affiliation>Heart Research Institute, 2050 Newtown, Australia; Sydney Medical School, University of Sydney, 2006 Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Aliyev</LastName>
<ForeName>Taghi</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huitema</LastName>
<ForeName>Leonie F A</ForeName>
<Initials>LFA</Initials>
<AffiliationInfo><Affiliation>Amsterdam Rheumatology and Immunology Center, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tas</LastName>
<ForeName>Sander W</ForeName>
<Initials>SW</Initials>
<AffiliationInfo><Affiliation>Amsterdam Rheumatology and Immunology Center, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wolfs</LastName>
<ForeName>Ine M J</ForeName>
<Initials>IMJ</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kuijpers</LastName>
<ForeName>Marijke J E</ForeName>
<Initials>MJE</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gijbels</LastName>
<ForeName>Marion J</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schalkwijk</LastName>
<ForeName>Casper G</ForeName>
<Initials>CG</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Koonen</LastName>
<ForeName>Debby P Y</ForeName>
<Initials>DPY</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Abdollahi-Roodsaz</LastName>
<ForeName>Shahla</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Rheumatology, Radboud University Nijmegen Medical Center, 6525 GA Nijmegen, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McDaniels</LastName>
<ForeName>Kimberly</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Chih-Chieh</ForeName>
<Initials>CC</Initials>
<AffiliationInfo><Affiliation>Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leitges</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Biotechnology Centre of Oslo, University of Oslo, 0313 Oslo, Norway.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lawrence</LastName>
<ForeName>Toby</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Inflammation Biology Group, Centre d'Immunologie Marseille-Luminy, 13288 Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Plat</LastName>
<ForeName>Jogchum</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Human Biology, Nutrim, Maastricht University, 6200 MD Maastricht, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Van Eck</LastName>
<ForeName>Miranda</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Division of Biopharmaceutics, Leiden Academic Center for Drug Research, Leiden University, 2333 CC Leiden, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rye</LastName>
<ForeName>Kerry-Anne</ForeName>
<Initials>KA</Initials>
<AffiliationInfo><Affiliation>Heart Research Institute, 2050 Newtown, Australia; Sydney Medical School, University of Sydney, 2006 Sydney, Australia; Centre for Vascular Research, University of New South Wales, 2052 Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Touqui</LastName>
<ForeName>Lhousseine</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Infection & Epidemiology, Institut Pasteur, 75015 Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Winther</LastName>
<ForeName>Menno P J</ForeName>
<Initials>MPJ</Initials>
<AffiliationInfo><Affiliation>Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Biessen</LastName>
<ForeName>Erik A L</ForeName>
<Initials>EAL</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; IMCARIM, Uniklinikum Aachen, 52074 Aachen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Donners</LastName>
<ForeName>Marjo M P C</ForeName>
<Initials>MMPC</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands. Electronic address: marjo.donners@maastrichtuniversity.nl.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>11</Month>
<Day>17</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Cell Metab</MedlineTA>
<NlmUniqueID>101233170</NlmUniqueID>
<ISSNLinking>1550-4131</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D050856">Interferon Regulatory Factor-1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008075">Lipoproteins, HDL</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016328">NF-kappa B</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D050794">STAT1 Transcription Factor</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D051193">Toll-Like Receptors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>97C5T2UQ7J</RegistryNumber>
<NameOfSubstance UI="D002784">Cholesterol</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.13</RegistryNumber>
<NameOfSubstance UI="D011493">Protein Kinase C</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001692" MajorTopicYN="N">Biological Transport</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002784" MajorTopicYN="N">Cholesterol</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050856" MajorTopicYN="N">Interferon Regulatory Factor-1</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008075" MajorTopicYN="N">Lipoproteins, HDL</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D021962" MajorTopicYN="N">Membrane Microdomains</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016328" MajorTopicYN="N">NF-kappa B</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011493" MajorTopicYN="N">Protein Kinase C</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012141" MajorTopicYN="N">Respiratory Tract Infections</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050794" MajorTopicYN="N">STAT1 Transcription Factor</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051193" MajorTopicYN="N">Toll-Like Receptors</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">bacterial infection</Keyword>
<Keyword MajorTopicYN="N">high-density lipoproteins</Keyword>
<Keyword MajorTopicYN="N">immune response</Keyword>
<Keyword MajorTopicYN="N">inflammation</Keyword>
<Keyword MajorTopicYN="N">inflammatory signaling</Keyword>
<Keyword MajorTopicYN="N">macrophages</Keyword>
<Keyword MajorTopicYN="N">passive cholesterol depletion</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year>
<Month>09</Month>
<Day>09</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2016</Year>
<Month>06</Month>
<Day>30</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>10</Month>
<Day>20</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>11</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>7</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>11</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">27866837</ArticleId>
<ArticleId IdType="pii">S1550-4131(16)30544-7</ArticleId>
<ArticleId IdType="doi">10.1016/j.cmet.2016.10.013</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>

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{{Explor lien
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   |area=    AustralieFrV1
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   |clé=     pubmed:27866837
   |texte=   High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.
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	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.

High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.

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