The Use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and Its Differential Diagnosis. An International Reproducibility Study in a Demanding Set of Cases.
Identifieur interne : 001096 ( PubMed/Curation ); précédent : 001095; suivant : 001097The Use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and Its Differential Diagnosis. An International Reproducibility Study in a Demanding Set of Cases.
Auteurs : Erik Thunnissen [Pays-Bas] ; Alain C. Borczuk [États-Unis] ; Douglas B. Flieder [États-Unis] ; Birgit Witte [Pays-Bas] ; Mary Beth Beasley [États-Unis] ; Jin-Haeng Chung [Corée du Sud] ; Sanja Dacic [États-Unis] ; Sylvie Lantuejoul [France] ; Prudence A. Russell [Australie] ; Michael Den Bakker [Pays-Bas] ; Johan Botling [Suède] ; Elisabeth Brambilla [France] ; Erienne De Cuba [Pays-Bas] ; Kim R. Geisinger [États-Unis] ; Kenzo Hiroshima [Japon] ; Alberto M. Marchevsky [États-Unis] ; Yuko Minami [Japon] ; Andre Moreira [États-Unis] ; Andrew G. Nicholson [Royaume-Uni] ; Akihiko Yoshida [Japon] ; Ming-Sound Tsao [Canada] ; Arne Warth [Allemagne] ; Edwina Duhig [Australie] ; Gang Chen [République populaire de Chine] ; Yoshihiro Matsuno [Japon] ; William D. Travis [États-Unis] ; Kelly Butnor [États-Unis] ; Wendy Cooper [Australie] ; Mari Mino-Kenudson [États-Unis] ; Noriko Motoi [Japon] ; Claudia Poleri [Argentine] ; Giuseppe Pelosi [Italie] ; Keith Kerr [Royaume-Uni] ; Seena C. Aisner [États-Unis] ; Yuichi Ishikawa [Japon] ; Reinhard H. Buettner [Allemagne] ; Naoto Keino [Japon] ; Yasushi Yatabe [Japon] ; Masayuki Noguchi [Japon]Source :
- Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [ 1556-1380 ] ; 2017.
Abstract
The current WHO classification of lung cancer states that a diagnosis of SCLC can be reliably made on routine histological and cytological grounds but immunohistochemistry (IHC) may be required, particularly (1) in cases in which histologic features are equivocal and (2) in cases in which the pathologist wants to increase confidence in diagnosis. However, reproducibility studies based on hematoxylin and eosin-stained slides alone for SCLC versus large cell neuroendocrine carcinoma (LCNEC) have shown pairwise κ scores ranging from 0.35 to 0.81. This study examines whether judicious use of IHC improves diagnostic reproducibility for SCLC.
DOI: 10.1016/j.jtho.2016.12.004
PubMed: 27998793
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001099
Links to Exploration step
pubmed:27998793Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and Its Differential Diagnosis. An International Reproducibility Study in a Demanding Set of Cases.</title><author><name sortKey="Thunnissen, Erik" sort="Thunnissen, Erik" uniqKey="Thunnissen E" first="Erik" last="Thunnissen">Erik Thunnissen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: e.thunnissen@vumc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, VU University Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Borczuk, Alain C" sort="Borczuk, Alain C" uniqKey="Borczuk A" first="Alain C" last="Borczuk">Alain C. Borczuk</name><affiliation wicri:level="2"><nlm:affiliation>Deptartment of Pathology, Weill Cornell Medicine, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Deptartment of Pathology, Weill Cornell Medicine, New York</wicri:cityArea></affiliation></author><author><name sortKey="Flieder, Douglas B" sort="Flieder, Douglas B" uniqKey="Flieder D" first="Douglas B" last="Flieder">Douglas B. Flieder</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pathology, Fox Chase Cancer Center, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Witte, Birgit" sort="Witte, Birgit" uniqKey="Witte B" first="Birgit" last="Witte">Birgit Witte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Beasley, Mary Beth" sort="Beasley, Mary Beth" uniqKey="Beasley M" first="Mary Beth" last="Beasley">Mary Beth Beasley</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Mount Sinai Medical Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pathology, Mount Sinai Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Chung, Jin Haeng" sort="Chung, Jin Haeng" uniqKey="Chung J" first="Jin-Haeng" last="Chung">Jin-Haeng Chung</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Dacic, Sanja" sort="Dacic, Sanja" uniqKey="Dacic S" first="Sanja" last="Dacic">Sanja Dacic</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology University of Pittsburgh, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pathology University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Lantuejoul, Sylvie" sort="Lantuejoul, Sylvie" uniqKey="Lantuejoul S" first="Sylvie" last="Lantuejoul">Sylvie Lantuejoul</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biopathology, Centre Léon Bérard UNICANCER, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Biopathology, Centre Léon Bérard UNICANCER, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Russell, Prudence A" sort="Russell, Prudence A" uniqKey="Russell P" first="Prudence A" last="Russell">Prudence A. Russell</name><affiliation wicri:level="1"><nlm:affiliation>St. Vincent's Pathology and The University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St. Vincent's Pathology and The University of Melbourne, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Den Bakker, Michael" sort="Den Bakker, Michael" uniqKey="Den Bakker M" first="Michael" last="Den Bakker">Michael Den Bakker</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Maasstad Ziekenhuis, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Pathology, Maasstad Ziekenhuis, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Botling, Johan" sort="Botling, Johan" uniqKey="Botling J" first="Johan" last="Botling">Johan Botling</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Brambilla, Elisabeth" sort="Brambilla, Elisabeth" uniqKey="Brambilla E" first="Elisabeth" last="Brambilla">Elisabeth Brambilla</name><affiliation wicri:level="1"><nlm:affiliation>CHU Albert Michallon-Institut de Biologie, Département d'Anatomie et Cytologie Pathologiques, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Albert Michallon-Institut de Biologie, Département d'Anatomie et Cytologie Pathologiques, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="De Cuba, Erienne" sort="De Cuba, Erienne" uniqKey="De Cuba E" first="Erienne" last="De Cuba">Erienne De Cuba</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, VU University Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Geisinger, Kim R" sort="Geisinger, Kim R" uniqKey="Geisinger K" first="Kim R" last="Geisinger">Kim R. Geisinger</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, The University of Mississippi Medical Center, Jackson, Mississippi.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>Department of Pathology, The University of Mississippi Medical Center, Jackson</wicri:cityArea></affiliation></author><author><name sortKey="Hiroshima, Kenzo" sort="Hiroshima, Kenzo" uniqKey="Hiroshima K" first="Kenzo" last="Hiroshima">Kenzo Hiroshima</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Tokyo Women's Medical University, Yachiyo Medical Center, Yachiyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Tokyo Women's Medical University, Yachiyo Medical Center, Yachiyo</wicri:regionArea></affiliation></author><author><name sortKey="Marchevsky, Alberto M" sort="Marchevsky, Alberto M" uniqKey="Marchevsky A" first="Alberto M" last="Marchevsky">Alberto M. Marchevsky</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Cedars Sinai Medical Center, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, Cedars Sinai Medical Center, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Minami, Yuko" sort="Minami, Yuko" uniqKey="Minami Y" first="Yuko" last="Minami">Yuko Minami</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba</wicri:regionArea></affiliation></author><author><name sortKey="Moreira, Andre" sort="Moreira, Andre" uniqKey="Moreira A" first="Andre" last="Moreira">Andre Moreira</name><affiliation wicri:level="2"><nlm:affiliation>Pulmonary Pathology, New York University Center for Biospecimen Research and Development, New York University, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Pulmonary Pathology, New York University Center for Biospecimen Research and Development, New York University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Nicholson, Andrew G" sort="Nicholson, Andrew G" uniqKey="Nicholson A" first="Andrew G" last="Nicholson">Andrew G. Nicholson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Histopathology, Royal Brompton and Harefield Hospitals National Health Service Foundation Trust and National Heart and Lung Institute, Imperial College, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Histopathology, Royal Brompton and Harefield Hospitals National Health Service Foundation Trust and National Heart and Lung Institute, Imperial College, London</wicri:regionArea></affiliation></author><author><name sortKey="Yoshida, Akihiko" sort="Yoshida, Akihiko" uniqKey="Yoshida A" first="Akihiko" last="Yoshida">Akihiko Yoshida</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Tsao, Ming Sound" sort="Tsao, Ming Sound" uniqKey="Tsao M" first="Ming-Sound" last="Tsao">Ming-Sound Tsao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Health Network-Princess Margaret Hospital and University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology, University Health Network-Princess Margaret Hospital and University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Warth, Arne" sort="Warth, Arne" uniqKey="Warth A" first="Arne" last="Warth">Arne Warth</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pathology, Heidelberg University, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Heidelberg University, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Duhig, Edwina" sort="Duhig, Edwina" uniqKey="Duhig E" first="Edwina" last="Duhig">Edwina Duhig</name><affiliation wicri:level="1"><nlm:affiliation>Sullivan Nicolaides Pathology, The John Flynn Hospital, Tugun, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sullivan Nicolaides Pathology, The John Flynn Hospital, Tugun, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Gang" sort="Chen, Gang" uniqKey="Chen G" first="Gang" last="Chen">Gang Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Matsuno, Yoshihiro" sort="Matsuno, Yoshihiro" uniqKey="Matsuno Y" first="Yoshihiro" last="Matsuno">Yoshihiro Matsuno</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgical Pathology, Hokkaido University Hospital, Sapporo</wicri:regionArea></affiliation></author><author><name sortKey="Travis, William D" sort="Travis, William D" uniqKey="Travis W" first="William D" last="Travis">William D. Travis</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Butnor, Kelly" sort="Butnor, Kelly" uniqKey="Butnor K" first="Kelly" last="Butnor">Kelly Butnor</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Cooper, Wendy" sort="Cooper, Wendy" uniqKey="Cooper W" first="Wendy" last="Cooper">Wendy Cooper</name><affiliation wicri:level="1"><nlm:affiliation>Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales</wicri:regionArea></affiliation></author><author><name sortKey="Mino Kenudson, Mari" sort="Mino Kenudson, Mari" uniqKey="Mino Kenudson M" first="Mari" last="Mino-Kenudson">Mari Mino-Kenudson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Motoi, Noriko" sort="Motoi, Noriko" uniqKey="Motoi N" first="Noriko" last="Motoi">Noriko Motoi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Poleri, Claudia" sort="Poleri, Claudia" uniqKey="Poleri C" first="Claudia" last="Poleri">Claudia Poleri</name><affiliation wicri:level="1"><nlm:affiliation>Laboratorio de Patología Torácica, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratorio de Patología Torácica, Buenos Aires</wicri:regionArea></affiliation></author><author><name sortKey="Pelosi, Giuseppe" sort="Pelosi, Giuseppe" uniqKey="Pelosi G" first="Giuseppe" last="Pelosi">Giuseppe Pelosi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Kerr, Keith" sort="Kerr, Keith" uniqKey="Kerr K" first="Keith" last="Kerr">Keith Kerr</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, Aberdeen Royal Infirmary, Aberdeen</wicri:regionArea></affiliation></author><author><name sortKey="Aisner, Seena C" sort="Aisner, Seena C" uniqKey="Aisner S" first="Seena C" last="Aisner">Seena C. Aisner</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine at Rutgers New Jersey Medical School, Rutgers University, Newark, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine at Rutgers New Jersey Medical School, Rutgers University, Newark</wicri:cityArea></affiliation></author><author><name sortKey="Ishikawa, Yuichi" sort="Ishikawa, Yuichi" uniqKey="Ishikawa Y" first="Yuichi" last="Ishikawa">Yuichi Ishikawa</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pathology, The Cancer Institute, Japan Foundation Cancer Research, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Pathology, The Cancer Institute, Japan Foundation Cancer Research, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Buettner, Reinhard H" sort="Buettner, Reinhard H" uniqKey="Buettner R" first="Reinhard H" last="Buettner">Reinhard H. Buettner</name><affiliation wicri:level="1"><nlm:affiliation>Cologne Institute for Pathology, Köln, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne Institute for Pathology, Köln</wicri:regionArea></affiliation></author><author><name sortKey="Keino, Naoto" sort="Keino, Naoto" uniqKey="Keino N" first="Naoto" last="Keino">Naoto Keino</name><affiliation wicri:level="1"><nlm:affiliation>Tsukuba Clinical Research and Development Organization, University of Tsukuba, Tsukuba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tsukuba Clinical Research and Development Organization, University of Tsukuba, Tsukuba</wicri:regionArea></affiliation></author><author><name sortKey="Yatabe, Yasushi" sort="Yatabe, Yasushi" uniqKey="Yatabe Y" first="Yasushi" last="Yatabe">Yasushi Yatabe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya</wicri:regionArea></affiliation></author><author><name sortKey="Noguchi, Masayuki" sort="Noguchi, Masayuki" uniqKey="Noguchi M" first="Masayuki" last="Noguchi">Masayuki Noguchi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27998793</idno><idno type="pmid">27998793</idno><idno type="doi">10.1016/j.jtho.2016.12.004</idno><idno type="wicri:Area/PubMed/Corpus">001099</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001099</idno><idno type="wicri:Area/PubMed/Curation">001096</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001096</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The Use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and Its Differential Diagnosis. An International Reproducibility Study in a Demanding Set of Cases.</title><author><name sortKey="Thunnissen, Erik" sort="Thunnissen, Erik" uniqKey="Thunnissen E" first="Erik" last="Thunnissen">Erik Thunnissen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: e.thunnissen@vumc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, VU University Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Borczuk, Alain C" sort="Borczuk, Alain C" uniqKey="Borczuk A" first="Alain C" last="Borczuk">Alain C. Borczuk</name><affiliation wicri:level="2"><nlm:affiliation>Deptartment of Pathology, Weill Cornell Medicine, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Deptartment of Pathology, Weill Cornell Medicine, New York</wicri:cityArea></affiliation></author><author><name sortKey="Flieder, Douglas B" sort="Flieder, Douglas B" uniqKey="Flieder D" first="Douglas B" last="Flieder">Douglas B. Flieder</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pathology, Fox Chase Cancer Center, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Witte, Birgit" sort="Witte, Birgit" uniqKey="Witte B" first="Birgit" last="Witte">Birgit Witte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Beasley, Mary Beth" sort="Beasley, Mary Beth" uniqKey="Beasley M" first="Mary Beth" last="Beasley">Mary Beth Beasley</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Mount Sinai Medical Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pathology, Mount Sinai Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Chung, Jin Haeng" sort="Chung, Jin Haeng" uniqKey="Chung J" first="Jin-Haeng" last="Chung">Jin-Haeng Chung</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Dacic, Sanja" sort="Dacic, Sanja" uniqKey="Dacic S" first="Sanja" last="Dacic">Sanja Dacic</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology University of Pittsburgh, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pathology University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Lantuejoul, Sylvie" sort="Lantuejoul, Sylvie" uniqKey="Lantuejoul S" first="Sylvie" last="Lantuejoul">Sylvie Lantuejoul</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biopathology, Centre Léon Bérard UNICANCER, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Biopathology, Centre Léon Bérard UNICANCER, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Russell, Prudence A" sort="Russell, Prudence A" uniqKey="Russell P" first="Prudence A" last="Russell">Prudence A. Russell</name><affiliation wicri:level="1"><nlm:affiliation>St. Vincent's Pathology and The University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St. Vincent's Pathology and The University of Melbourne, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Den Bakker, Michael" sort="Den Bakker, Michael" uniqKey="Den Bakker M" first="Michael" last="Den Bakker">Michael Den Bakker</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Maasstad Ziekenhuis, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Pathology, Maasstad Ziekenhuis, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Botling, Johan" sort="Botling, Johan" uniqKey="Botling J" first="Johan" last="Botling">Johan Botling</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Brambilla, Elisabeth" sort="Brambilla, Elisabeth" uniqKey="Brambilla E" first="Elisabeth" last="Brambilla">Elisabeth Brambilla</name><affiliation wicri:level="1"><nlm:affiliation>CHU Albert Michallon-Institut de Biologie, Département d'Anatomie et Cytologie Pathologiques, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Albert Michallon-Institut de Biologie, Département d'Anatomie et Cytologie Pathologiques, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="De Cuba, Erienne" sort="De Cuba, Erienne" uniqKey="De Cuba E" first="Erienne" last="De Cuba">Erienne De Cuba</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, VU University Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Geisinger, Kim R" sort="Geisinger, Kim R" uniqKey="Geisinger K" first="Kim R" last="Geisinger">Kim R. Geisinger</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, The University of Mississippi Medical Center, Jackson, Mississippi.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>Department of Pathology, The University of Mississippi Medical Center, Jackson</wicri:cityArea></affiliation></author><author><name sortKey="Hiroshima, Kenzo" sort="Hiroshima, Kenzo" uniqKey="Hiroshima K" first="Kenzo" last="Hiroshima">Kenzo Hiroshima</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Tokyo Women's Medical University, Yachiyo Medical Center, Yachiyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Tokyo Women's Medical University, Yachiyo Medical Center, Yachiyo</wicri:regionArea></affiliation></author><author><name sortKey="Marchevsky, Alberto M" sort="Marchevsky, Alberto M" uniqKey="Marchevsky A" first="Alberto M" last="Marchevsky">Alberto M. Marchevsky</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Cedars Sinai Medical Center, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, Cedars Sinai Medical Center, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Minami, Yuko" sort="Minami, Yuko" uniqKey="Minami Y" first="Yuko" last="Minami">Yuko Minami</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba</wicri:regionArea></affiliation></author><author><name sortKey="Moreira, Andre" sort="Moreira, Andre" uniqKey="Moreira A" first="Andre" last="Moreira">Andre Moreira</name><affiliation wicri:level="2"><nlm:affiliation>Pulmonary Pathology, New York University Center for Biospecimen Research and Development, New York University, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Pulmonary Pathology, New York University Center for Biospecimen Research and Development, New York University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Nicholson, Andrew G" sort="Nicholson, Andrew G" uniqKey="Nicholson A" first="Andrew G" last="Nicholson">Andrew G. Nicholson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Histopathology, Royal Brompton and Harefield Hospitals National Health Service Foundation Trust and National Heart and Lung Institute, Imperial College, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Histopathology, Royal Brompton and Harefield Hospitals National Health Service Foundation Trust and National Heart and Lung Institute, Imperial College, London</wicri:regionArea></affiliation></author><author><name sortKey="Yoshida, Akihiko" sort="Yoshida, Akihiko" uniqKey="Yoshida A" first="Akihiko" last="Yoshida">Akihiko Yoshida</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Tsao, Ming Sound" sort="Tsao, Ming Sound" uniqKey="Tsao M" first="Ming-Sound" last="Tsao">Ming-Sound Tsao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Health Network-Princess Margaret Hospital and University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology, University Health Network-Princess Margaret Hospital and University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Warth, Arne" sort="Warth, Arne" uniqKey="Warth A" first="Arne" last="Warth">Arne Warth</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pathology, Heidelberg University, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Heidelberg University, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Duhig, Edwina" sort="Duhig, Edwina" uniqKey="Duhig E" first="Edwina" last="Duhig">Edwina Duhig</name><affiliation wicri:level="1"><nlm:affiliation>Sullivan Nicolaides Pathology, The John Flynn Hospital, Tugun, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sullivan Nicolaides Pathology, The John Flynn Hospital, Tugun, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Gang" sort="Chen, Gang" uniqKey="Chen G" first="Gang" last="Chen">Gang Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Matsuno, Yoshihiro" sort="Matsuno, Yoshihiro" uniqKey="Matsuno Y" first="Yoshihiro" last="Matsuno">Yoshihiro Matsuno</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgical Pathology, Hokkaido University Hospital, Sapporo</wicri:regionArea></affiliation></author><author><name sortKey="Travis, William D" sort="Travis, William D" uniqKey="Travis W" first="William D" last="Travis">William D. Travis</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Butnor, Kelly" sort="Butnor, Kelly" uniqKey="Butnor K" first="Kelly" last="Butnor">Kelly Butnor</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Cooper, Wendy" sort="Cooper, Wendy" uniqKey="Cooper W" first="Wendy" last="Cooper">Wendy Cooper</name><affiliation wicri:level="1"><nlm:affiliation>Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales</wicri:regionArea></affiliation></author><author><name sortKey="Mino Kenudson, Mari" sort="Mino Kenudson, Mari" uniqKey="Mino Kenudson M" first="Mari" last="Mino-Kenudson">Mari Mino-Kenudson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Motoi, Noriko" sort="Motoi, Noriko" uniqKey="Motoi N" first="Noriko" last="Motoi">Noriko Motoi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Poleri, Claudia" sort="Poleri, Claudia" uniqKey="Poleri C" first="Claudia" last="Poleri">Claudia Poleri</name><affiliation wicri:level="1"><nlm:affiliation>Laboratorio de Patología Torácica, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratorio de Patología Torácica, Buenos Aires</wicri:regionArea></affiliation></author><author><name sortKey="Pelosi, Giuseppe" sort="Pelosi, Giuseppe" uniqKey="Pelosi G" first="Giuseppe" last="Pelosi">Giuseppe Pelosi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Kerr, Keith" sort="Kerr, Keith" uniqKey="Kerr K" first="Keith" last="Kerr">Keith Kerr</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, Aberdeen Royal Infirmary, Aberdeen</wicri:regionArea></affiliation></author><author><name sortKey="Aisner, Seena C" sort="Aisner, Seena C" uniqKey="Aisner S" first="Seena C" last="Aisner">Seena C. Aisner</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine at Rutgers New Jersey Medical School, Rutgers University, Newark, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine at Rutgers New Jersey Medical School, Rutgers University, Newark</wicri:cityArea></affiliation></author><author><name sortKey="Ishikawa, Yuichi" sort="Ishikawa, Yuichi" uniqKey="Ishikawa Y" first="Yuichi" last="Ishikawa">Yuichi Ishikawa</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pathology, The Cancer Institute, Japan Foundation Cancer Research, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Pathology, The Cancer Institute, Japan Foundation Cancer Research, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Buettner, Reinhard H" sort="Buettner, Reinhard H" uniqKey="Buettner R" first="Reinhard H" last="Buettner">Reinhard H. Buettner</name><affiliation wicri:level="1"><nlm:affiliation>Cologne Institute for Pathology, Köln, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne Institute for Pathology, Köln</wicri:regionArea></affiliation></author><author><name sortKey="Keino, Naoto" sort="Keino, Naoto" uniqKey="Keino N" first="Naoto" last="Keino">Naoto Keino</name><affiliation wicri:level="1"><nlm:affiliation>Tsukuba Clinical Research and Development Organization, University of Tsukuba, Tsukuba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tsukuba Clinical Research and Development Organization, University of Tsukuba, Tsukuba</wicri:regionArea></affiliation></author><author><name sortKey="Yatabe, Yasushi" sort="Yatabe, Yasushi" uniqKey="Yatabe Y" first="Yasushi" last="Yatabe">Yasushi Yatabe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya</wicri:regionArea></affiliation></author><author><name sortKey="Noguchi, Masayuki" sort="Noguchi, Masayuki" uniqKey="Noguchi M" first="Masayuki" last="Noguchi">Masayuki Noguchi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer</title><idno type="eISSN">1556-1380</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The current WHO classification of lung cancer states that a diagnosis of SCLC can be reliably made on routine histological and cytological grounds but immunohistochemistry (IHC) may be required, particularly (1) in cases in which histologic features are equivocal and (2) in cases in which the pathologist wants to increase confidence in diagnosis. However, reproducibility studies based on hematoxylin and eosin-stained slides alone for SCLC versus large cell neuroendocrine carcinoma (LCNEC) have shown pairwise κ scores ranging from 0.35 to 0.81. This study examines whether judicious use of IHC improves diagnostic reproducibility for SCLC.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27998793</PMID><DateCreated><Year>2016</Year><Month>12</Month><Day>21</Day></DateCreated><DateRevised><Year>2017</Year><Month>01</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1556-1380</ISSN><JournalIssue CitedMedium="Internet"><Volume>12</Volume><Issue>2</Issue><PubDate><Year>2017</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer</Title><ISOAbbreviation>J Thorac Oncol</ISOAbbreviation></Journal><ArticleTitle>The Use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and Its Differential Diagnosis. An International Reproducibility Study in a Demanding Set of Cases.</ArticleTitle><Pagination><MedlinePgn>334-346</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1556-0864(16)33572-9</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jtho.2016.12.004</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">The current WHO classification of lung cancer states that a diagnosis of SCLC can be reliably made on routine histological and cytological grounds but immunohistochemistry (IHC) may be required, particularly (1) in cases in which histologic features are equivocal and (2) in cases in which the pathologist wants to increase confidence in diagnosis. However, reproducibility studies based on hematoxylin and eosin-stained slides alone for SCLC versus large cell neuroendocrine carcinoma (LCNEC) have shown pairwise κ scores ranging from 0.35 to 0.81. This study examines whether judicious use of IHC improves diagnostic reproducibility for SCLC.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Nineteen lung pathologists studied interactive digital images of 79 tumors, predominantly neuroendocrine lung tumors. Images of resection and biopsy specimens were used to make diagnoses solely on the basis of morphologic features (level 1), morphologic features along with requested IHC staining results (level 2), and all available IHC staining results (level 3).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">For the 19 pathologists reading all 79 cases, the rate of agreement for level 1 was 64.7%, and it increased to 73.2% and 77.5% in levels 2 and 3, respectively. With IHC, κ scores for four tumor categories (SCLC, LCNEC, carcinoid tumors, and other) increased in resection samples from 0.43 to 0.60 and in biopsy specimens from 0.43 to 0.64.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Diagnosis using hematoxylin and eosin staining alone showeds moderate agreement among pathologists in tumors with neuroendocrine morphology, but agreement improved to good in most cases with the judicious use of IHC, especially in the diagnosis of SCLC. An approach for IHC in the differential diagnosis of SCLC is provided.</AbstractText><CopyrightInformation>Copyright © 2017 International Association for the Study of Lung Cancer. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Thunnissen</LastName><ForeName>Erik</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: e.thunnissen@vumc.nl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borczuk</LastName><ForeName>Alain C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>Deptartment of Pathology, Weill Cornell Medicine, New York, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Flieder</LastName><ForeName>Douglas B</ForeName><Initials>DB</Initials><AffiliationInfo><Affiliation>Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Witte</LastName><ForeName>Birgit</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beasley</LastName><ForeName>Mary Beth</ForeName><Initials>MB</Initials><AffiliationInfo><Affiliation>Department of Pathology, Mount Sinai Medical Center, New York, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>Jin-Haeng</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dacic</LastName><ForeName>Sanja</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pathology University of Pittsburgh, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lantuejoul</LastName><ForeName>Sylvie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biopathology, Centre Léon Bérard UNICANCER, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Russell</LastName><ForeName>Prudence A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>St. Vincent's Pathology and The University of Melbourne, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>den Bakker</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pathology, Maasstad Ziekenhuis, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Botling</LastName><ForeName>Johan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brambilla</LastName><ForeName>Elisabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>CHU Albert Michallon-Institut de Biologie, Département d'Anatomie et Cytologie Pathologiques, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Cuba</LastName><ForeName>Erienne</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Geisinger</LastName><ForeName>Kim R</ForeName><Initials>KR</Initials><AffiliationInfo><Affiliation>Department of Pathology, The University of Mississippi Medical Center, Jackson, Mississippi.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hiroshima</LastName><ForeName>Kenzo</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Pathology, Tokyo Women's Medical University, Yachiyo Medical Center, Yachiyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marchevsky</LastName><ForeName>Alberto M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Pathology, Cedars Sinai Medical Center, Los Angeles, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Minami</LastName><ForeName>Yuko</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moreira</LastName><ForeName>Andre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Pulmonary Pathology, New York University Center for Biospecimen Research and Development, New York University, New York, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nicholson</LastName><ForeName>Andrew G</ForeName><Initials>AG</Initials><AffiliationInfo><Affiliation>Department of Histopathology, Royal Brompton and Harefield Hospitals National Health Service Foundation Trust and National Heart and Lung Institute, Imperial College, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yoshida</LastName><ForeName>Akihiko</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsao</LastName><ForeName>Ming-Sound</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Department of Pathology, University Health Network-Princess Margaret Hospital and University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Warth</LastName><ForeName>Arne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Pathology, Heidelberg University, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duhig</LastName><ForeName>Edwina</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Sullivan Nicolaides Pathology, The John Flynn Hospital, Tugun, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Gang</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matsuno</LastName><ForeName>Yoshihiro</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Travis</LastName><ForeName>William D</ForeName><Initials>WD</Initials><AffiliationInfo><Affiliation>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Butnor</LastName><ForeName>Kelly</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Vermont, Burlington, Vermont.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cooper</LastName><ForeName>Wendy</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mino-Kenudson</LastName><ForeName>Mari</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Motoi</LastName><ForeName>Noriko</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Poleri</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratorio de Patología Torácica, Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pelosi</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kerr</LastName><ForeName>Keith</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Pathology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aisner</LastName><ForeName>Seena C</ForeName><Initials>SC</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine at Rutgers New Jersey Medical School, Rutgers University, Newark, New Jersey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ishikawa</LastName><ForeName>Yuichi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Division of Pathology, The Cancer Institute, Japan Foundation Cancer Research, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buettner</LastName><ForeName>Reinhard H</ForeName><Initials>RH</Initials><AffiliationInfo><Affiliation>Cologne Institute for Pathology, Köln, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Keino</LastName><ForeName>Naoto</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Tsukuba Clinical Research and Development Organization, University of Tsukuba, Tsukuba, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yatabe</LastName><ForeName>Yasushi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Noguchi</LastName><ForeName>Masayuki</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>12</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Thorac Oncol</MedlineTA><NlmUniqueID>101274235</NlmUniqueID><ISSNLinking>1556-0864</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Histopathology</Keyword><Keyword MajorTopicYN="N">Immunohistochemistry</Keyword><Keyword MajorTopicYN="N">Reproducibility</Keyword><Keyword MajorTopicYN="N">SCLC</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>09</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>11</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>12</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>12</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>12</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27998793</ArticleId><ArticleId IdType="pii">S1556-0864(16)33572-9</ArticleId><ArticleId IdType="doi">10.1016/j.jtho.2016.12.004</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001096 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 001096 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:27998793
|texte= The Use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and Its Differential Diagnosis. An International Reproducibility Study in a Demanding Set of Cases.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:27998793" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |