Higher Complexity of Infection and Genetic Diversity of Plasmodium vivax Than Plasmodium falciparum Across All Malaria Transmission Zones of Papua New Guinea.
Identifieur interne : 001028 ( PubMed/Curation ); précédent : 001027; suivant : 001029Higher Complexity of Infection and Genetic Diversity of Plasmodium vivax Than Plasmodium falciparum Across All Malaria Transmission Zones of Papua New Guinea.
Auteurs : Abebe A. Fola [Australie] ; G L Abby Harrison [Australie] ; Mita Hapsari Hazairin [Australie] ; Céline Barnadas [Danemark] ; Manuel W. Hetzel [Suisse] ; Jonah Iga [Papouasie-Nouvelle-Guinée] ; Peter M. Siba [Papouasie-Nouvelle-Guinée] ; Ivo Mueller [France] ; Alyssa E. Barry [Australie]Source :
- The American journal of tropical medicine and hygiene [ 1476-1645 ] ; 2017.
Descripteurs français
- KwdFr :
- ADN des protozoaires (génétique), Allèles, Analyse de séquence d'ADN, Humains, Paludisme à Plasmodium falciparum (épidémiologie), Paludisme à Plasmodium vivax (épidémiologie), Papouasie - Nouvelle-Guinée (épidémiologie), Plasmodium falciparum (génétique), Plasmodium vivax (génétique), Prévalence, Variation génétique, Épidémiologie moléculaire.
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : DNA, Protozoan.
- epidemiology : Malaria, Falciparum, Malaria, Vivax, Papua New Guinea.
- genetics : Plasmodium falciparum, Plasmodium vivax.
- Alleles, Genetic Variation, Humans, Molecular Epidemiology, Prevalence, Sequence Analysis, DNA.
Abstract
AbstractPlasmodium falciparum and Plasmodium vivax have varying transmission dynamics that are informed by molecular epidemiology. This study aimed to determine the complexity of infection and genetic diversity of P. vivax and P. falciparum throughout Papua New Guinea (PNG) to evaluate transmission dynamics across the country. In 2008-2009, a nationwide malaria indicator survey collected 8,936 samples from all 16 endemic provinces of PNG. Of these, 892 positive P. vivax samples were genotyped at PvMS16 and PvmspF3, and 758 positive P. falciparum samples were genotyped at Pfmsp2. The data were analyzed for multiplicity of infection (MOI) and genetic diversity. Overall, P. vivax had higher polyclonality (71%) and mean MOI (2.32) than P. falciparum (20%, 1.39). These measures were significantly associated with prevalence for P. falciparum but not for P. vivax. The genetic diversity of P. vivax (PvMS16: expected heterozygosity = 0.95, 0.85-0.98; PvMsp1F3: 0.78, 0.66-0.89) was higher and less variable than that of P. falciparum (Pfmsp2: 0.89, 0.65-0.97). Significant associations of MOI with allelic richness (rho = 0.69, P = 0.009) and expected heterozygosity (rho = 0.87, P < 0.001) were observed for P. falciparum. Conversely, genetic diversity was not correlated with polyclonality nor mean MOI for P. vivax. The results demonstrate higher complexity of infection and genetic diversity of P. vivax across the country. Although P. falciparum shows a strong association of these parameters with prevalence, a lack of association was observed for P. vivax and is consistent with higher potential for outcrossing of this species.
DOI: 10.4269/ajtmh.16-0716
PubMed: 28070005
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Fola</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea></affiliation></author><author><name sortKey="Harrison, G L Abby" sort="Harrison, G L Abby" uniqKey="Harrison G" first="G L Abby" last="Harrison">G L Abby Harrison</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea></affiliation></author><author><name sortKey="Hazairin, Mita Hapsari" sort="Hazairin, Mita Hapsari" uniqKey="Hazairin M" first="Mita Hapsari" last="Hazairin">Mita Hapsari Hazairin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Preventative Medicine, Monash University, Clayton, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Epidemiology and Preventative Medicine, Monash University, Clayton</wicri:regionArea></affiliation></author><author><name sortKey="Barnadas, Celine" sort="Barnadas, Celine" uniqKey="Barnadas C" first="Céline" last="Barnadas">Céline Barnadas</name><affiliation wicri:level="1"><nlm:affiliation>Statens Serum Institut, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Statens Serum Institut, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Hetzel, Manuel W" sort="Hetzel, Manuel W" uniqKey="Hetzel M" first="Manuel W" last="Hetzel">Manuel W. Hetzel</name><affiliation wicri:level="1"><nlm:affiliation>University of Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Basel, Basel</wicri:regionArea></affiliation></author><author><name sortKey="Iga, Jonah" sort="Iga, Jonah" uniqKey="Iga J" first="Jonah" last="Iga">Jonah Iga</name><affiliation wicri:level="1"><nlm:affiliation>Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.</nlm:affiliation><country xml:lang="fr">Papouasie-Nouvelle-Guinée</country><wicri:regionArea>Papua New Guinea Institute of Medical Research, Goroka</wicri:regionArea></affiliation></author><author><name sortKey="Siba, Peter M" sort="Siba, Peter M" uniqKey="Siba P" first="Peter M" last="Siba">Peter M. Siba</name><affiliation wicri:level="1"><nlm:affiliation>Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.</nlm:affiliation><country xml:lang="fr">Papouasie-Nouvelle-Guinée</country><wicri:regionArea>Papua New Guinea Institute of Medical Research, Goroka</wicri:regionArea></affiliation></author><author><name sortKey="Mueller, Ivo" sort="Mueller, Ivo" uniqKey="Mueller I" first="Ivo" last="Mueller">Ivo Mueller</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Barry, Alyssa E" sort="Barry, Alyssa E" uniqKey="Barry A" first="Alyssa E" last="Barry">Alyssa E. Barry</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, University of Melbourne, Parkville</wicri:regionArea></affiliation></author></analytic><series><title level="j">The American journal of tropical medicine and hygiene</title><idno type="eISSN">1476-1645</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles</term><term>DNA, Protozoan (genetics)</term><term>Genetic Variation</term><term>Humans</term><term>Malaria, Falciparum (epidemiology)</term><term>Malaria, Vivax (epidemiology)</term><term>Molecular Epidemiology</term><term>Papua New Guinea (epidemiology)</term><term>Plasmodium falciparum (genetics)</term><term>Plasmodium vivax (genetics)</term><term>Prevalence</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN des protozoaires (génétique)</term><term>Allèles</term><term>Analyse de séquence d'ADN</term><term>Humains</term><term>Paludisme à Plasmodium falciparum (épidémiologie)</term><term>Paludisme à Plasmodium vivax (épidémiologie)</term><term>Papouasie - Nouvelle-Guinée (épidémiologie)</term><term>Plasmodium falciparum (génétique)</term><term>Plasmodium vivax (génétique)</term><term>Prévalence</term><term>Variation génétique</term><term>Épidémiologie moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Protozoan</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Malaria, Falciparum</term><term>Malaria, Vivax</term><term>Papua New Guinea</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Plasmodium falciparum</term><term>Plasmodium vivax</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN des protozoaires</term><term>Plasmodium falciparum</term><term>Plasmodium vivax</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Paludisme à Plasmodium falciparum</term><term>Paludisme à Plasmodium vivax</term><term>Papouasie - Nouvelle-Guinée</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Genetic Variation</term><term>Humans</term><term>Molecular Epidemiology</term><term>Prevalence</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Allèles</term><term>Analyse de séquence d'ADN</term><term>Humains</term><term>Prévalence</term><term>Variation génétique</term><term>Épidémiologie moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">AbstractPlasmodium falciparum and Plasmodium vivax have varying transmission dynamics that are informed by molecular epidemiology. This study aimed to determine the complexity of infection and genetic diversity of P. vivax and P. falciparum throughout Papua New Guinea (PNG) to evaluate transmission dynamics across the country. In 2008-2009, a nationwide malaria indicator survey collected 8,936 samples from all 16 endemic provinces of PNG. Of these, 892 positive P. vivax samples were genotyped at PvMS16 and PvmspF3, and 758 positive P. falciparum samples were genotyped at Pfmsp2. The data were analyzed for multiplicity of infection (MOI) and genetic diversity. Overall, P. vivax had higher polyclonality (71%) and mean MOI (2.32) than P. falciparum (20%, 1.39). These measures were significantly associated with prevalence for P. falciparum but not for P. vivax. The genetic diversity of P. vivax (PvMS16: expected heterozygosity = 0.95, 0.85-0.98; PvMsp1F3: 0.78, 0.66-0.89) was higher and less variable than that of P. falciparum (Pfmsp2: 0.89, 0.65-0.97). Significant associations of MOI with allelic richness (rho = 0.69, P = 0.009) and expected heterozygosity (rho = 0.87, P < 0.001) were observed for P. falciparum. Conversely, genetic diversity was not correlated with polyclonality nor mean MOI for P. vivax. The results demonstrate higher complexity of infection and genetic diversity of P. vivax across the country. Although P. falciparum shows a strong association of these parameters with prevalence, a lack of association was observed for P. vivax and is consistent with higher potential for outcrossing of this species.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28070005</PMID><DateCreated><Year>2017</Year><Month>01</Month><Day>10</Day></DateCreated><DateCompleted><Year>2017</Year><Month>07</Month><Day>31</Day></DateCompleted><DateRevised><Year>2017</Year><Month>07</Month><Day>31</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-1645</ISSN><JournalIssue CitedMedium="Internet"><Volume>96</Volume><Issue>3</Issue><PubDate><Year>2017</Year><Month>Mar</Month></PubDate></JournalIssue><Title>The American journal of tropical medicine and hygiene</Title><ISOAbbreviation>Am. J. Trop. Med. Hyg.</ISOAbbreviation></Journal><ArticleTitle>Higher Complexity of Infection and Genetic Diversity of Plasmodium vivax Than Plasmodium falciparum Across All Malaria Transmission Zones of Papua New Guinea.</ArticleTitle><Pagination><MedlinePgn>630-641</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4269/ajtmh.16-0716</ELocationID><Abstract><AbstractText>AbstractPlasmodium falciparum and Plasmodium vivax have varying transmission dynamics that are informed by molecular epidemiology. This study aimed to determine the complexity of infection and genetic diversity of P. vivax and P. falciparum throughout Papua New Guinea (PNG) to evaluate transmission dynamics across the country. In 2008-2009, a nationwide malaria indicator survey collected 8,936 samples from all 16 endemic provinces of PNG. Of these, 892 positive P. vivax samples were genotyped at PvMS16 and PvmspF3, and 758 positive P. falciparum samples were genotyped at Pfmsp2. The data were analyzed for multiplicity of infection (MOI) and genetic diversity. Overall, P. vivax had higher polyclonality (71%) and mean MOI (2.32) than P. falciparum (20%, 1.39). These measures were significantly associated with prevalence for P. falciparum but not for P. vivax. The genetic diversity of P. vivax (PvMS16: expected heterozygosity = 0.95, 0.85-0.98; PvMsp1F3: 0.78, 0.66-0.89) was higher and less variable than that of P. falciparum (Pfmsp2: 0.89, 0.65-0.97). Significant associations of MOI with allelic richness (rho = 0.69, P = 0.009) and expected heterozygosity (rho = 0.87, P < 0.001) were observed for P. falciparum. Conversely, genetic diversity was not correlated with polyclonality nor mean MOI for P. vivax. The results demonstrate higher complexity of infection and genetic diversity of P. vivax across the country. Although P. falciparum shows a strong association of these parameters with prevalence, a lack of association was observed for P. vivax and is consistent with higher potential for outcrossing of this species.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fola</LastName><ForeName>Abebe A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harrison</LastName><ForeName>G L Abby</ForeName><Initials>GLA</Initials><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hazairin</LastName><ForeName>Mita Hapsari</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Preventative Medicine, Monash University, Clayton, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barnadas</LastName><ForeName>Céline</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Statens Serum Institut, Copenhagen, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>European Public Health Microbiology (EUPHEM) Training Programme, European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hetzel</LastName><ForeName>Manuel W</ForeName><Initials>MW</Initials><AffiliationInfo><Affiliation>University of Basel, Basel, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iga</LastName><ForeName>Jonah</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siba</LastName><ForeName>Peter M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mueller</LastName><ForeName>Ivo</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Institut Pasteur, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barry</LastName><ForeName>Alyssa E</ForeName><Initials>AE</Initials><AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>04</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Trop Med Hyg</MedlineTA><NlmUniqueID>0370507</NlmUniqueID><ISSNLinking>0002-9637</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016054">DNA, Protozoan</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000483" MajorTopicYN="N">Alleles</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016054" MajorTopicYN="N">DNA, Protozoan</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014644" MajorTopicYN="Y">Genetic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016778" MajorTopicYN="N">Malaria, Falciparum</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016780" MajorTopicYN="N">Malaria, Vivax</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017720" MajorTopicYN="N">Molecular Epidemiology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010219" MajorTopicYN="N">Papua New Guinea</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010963" MajorTopicYN="N">Plasmodium falciparum</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010966" MajorTopicYN="N">Plasmodium vivax</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>1</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>8</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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