Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI).
Identifieur interne : 000C45 ( PubMed/Curation ); précédent : 000C44; suivant : 000C46Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI).
Auteurs : Pradeep J. Nathan [Royaume-Uni] ; Yen Ying Lim [Australie] ; Rosemary Abbott [Royaume-Uni] ; Samantha Galluzzi [Italie] ; Moira Marizzoni [Italie] ; Claudio Babiloni [Italie] ; Diego Albani [Italie] ; David Bartres-Faz [Espagne] ; Mira Didic [France] ; Lucia Farotti [Italie] ; Lucilla Parnetti [Italie] ; Nicola Salvadori [Italie] ; Bernhard W. Müller [Allemagne] ; Gianluigi Forloni [Italie] ; Nicola Girtler [Italie] ; Tilman Hensch [Allemagne] ; Jorge Jovicich [Italie] ; Annebet Leeuwis [Pays-Bas] ; Camillo Marra [Italie] ; José Luis Molinuevo [Espagne] ; Flavio Nobili [Italie] ; Jeremie Pariente [France] ; Pierre Payoux [France] ; Jean-Philippe Ranjeva [France] ; Elena Rolandi [Italie] ; Paolo Maria Rossini [Italie] ; Peter Schönknecht [Allemagne] ; Andrea Soricelli [Italie] ; Magda Tsolaki [Grèce] ; Pieter Jelle Visser [Pays-Bas] ; Jens Wiltfang [Allemagne] ; Jill C. Richardson [Royaume-Uni] ; Régis Bordet [France] ; Olivier Blin [France] ; Giovanni B. Frisoni [Suisse]Source :
- Neurobiology of aging [ 1558-1497 ] ; 2017.
Abstract
Few studies have examined the relationship between CSF and structural biomarkers, and cognitive function in MCI. We examined the relationship between cognitive function, hippocampal volume and cerebrospinal fluid (CSF) Aβ42 and tau in 145 patients with MCI. Patients were assessed on cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), the Geriatric Depression Scale and the Functional Activities Questionnaire. Hippocampal volume was measured using magnetic resonance imaging (MRI), and CSF markers of Aβ42, tau and p-tau181 were also measured. Worse performance on a wide range of memory and sustained attention tasks were associated with reduced hippocampal volume, higher CSF tau and p-tau181 and increased tau/Aβ42 ratio. Memory tasks were also associated with lower ability to conduct functional activities of daily living, providing a link between AD biomarkers, memory performance and functional outcome. These results suggest that biomarkers of Aβ and tau are strongly related to cognitive performance as assessed by the CANTAB, and have implications for the early detection and characterization of incipient AD.
DOI: 10.1016/j.neurobiolaging.2017.01.013
PubMed: 28189924
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI).</title><author><name sortKey="Nathan, Pradeep J" sort="Nathan, Pradeep J" uniqKey="Nathan P" first="Pradeep J" last="Nathan">Pradeep J. Nathan</name><affiliation wicri:level="1"><nlm:affiliation>Heptares Therapeutics Ltd, Cambridge, UK; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK. Electronic address: pradeep.nathan@heptares.com.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Heptares Therapeutics Ltd, Cambridge, UK; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Lim, Yen Ying" sort="Lim, Yen Ying" uniqKey="Lim Y" first="Yen Ying" last="Lim">Yen Ying Lim</name><affiliation wicri:level="1"><nlm:affiliation>The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia. Electronic address: yen.lim@florey.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Abbott, Rosemary" sort="Abbott, Rosemary" uniqKey="Abbott R" first="Rosemary" last="Abbott">Rosemary Abbott</name><affiliation wicri:level="1"><nlm:affiliation>Cambridge Cognition, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge Cognition, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Galluzzi, Samantha" sort="Galluzzi, Samantha" uniqKey="Galluzzi S" first="Samantha" last="Galluzzi">Samantha Galluzzi</name><affiliation wicri:level="1"><nlm:affiliation>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia</wicri:regionArea></affiliation></author><author><name sortKey="Marizzoni, Moira" sort="Marizzoni, Moira" uniqKey="Marizzoni M" first="Moira" last="Marizzoni">Moira Marizzoni</name><affiliation wicri:level="1"><nlm:affiliation>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia</wicri:regionArea></affiliation></author><author><name sortKey="Babiloni, Claudio" sort="Babiloni, Claudio" uniqKey="Babiloni C" first="Claudio" last="Babiloni">Claudio Babiloni</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy; IRCCS San Raffaele Pisana of Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy; IRCCS San Raffaele Pisana of Rome</wicri:regionArea></affiliation></author><author><name sortKey="Albani, Diego" sort="Albani, Diego" uniqKey="Albani D" first="Diego" last="Albani">Diego Albani</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano</wicri:regionArea></affiliation></author><author><name sortKey="Bartres Faz, David" sort="Bartres Faz, David" uniqKey="Bartres Faz D" first="David" last="Bartres-Faz">David Bartres-Faz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya</wicri:regionArea></affiliation></author><author><name sortKey="Didic, Mira" sort="Didic, Mira" uniqKey="Didic M" first="Mira" last="Didic">Mira Didic</name><affiliation wicri:level="1"><nlm:affiliation>Aix-Marseille Université, INSERM, INS UMR_S 1106, Marseille, France; Service de Neurologie et Neuropsychologie, APHM Hôpital Timone Adultes, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, INSERM, INS UMR_S 1106, Marseille, France; Service de Neurologie et Neuropsychologie, APHM Hôpital Timone Adultes, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Farotti, Lucia" sort="Farotti, Lucia" uniqKey="Farotti L" first="Lucia" last="Farotti">Lucia Farotti</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Neurologica, Centro Disturbi della Memoria, Università di Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Neurologica, Centro Disturbi della Memoria, Università di Perugia, Ospedale Santa Maria della Misericordia, Perugia</wicri:regionArea></affiliation></author><author><name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Neurologica, Centro Disturbi della Memoria, Università di Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Neurologica, Centro Disturbi della Memoria, Università di Perugia, Ospedale Santa Maria della Misericordia, Perugia</wicri:regionArea></affiliation></author><author><name sortKey="Salvadori, Nicola" sort="Salvadori, Nicola" uniqKey="Salvadori N" first="Nicola" last="Salvadori">Nicola Salvadori</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Neurologica, Centro Disturbi della Memoria, Università di Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Neurologica, Centro Disturbi della Memoria, Università di Perugia, Ospedale Santa Maria della Misericordia, Perugia</wicri:regionArea></affiliation></author><author><name sortKey="Muller, Bernhard W" sort="Muller, Bernhard W" uniqKey="Muller B" first="Bernhard W" last="Müller">Bernhard W. Müller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, LVR-Hospital Essen, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, LVR-Hospital Essen, Faculty of Medicine, University of Duisburg-Essen, Essen</wicri:regionArea></affiliation></author><author><name sortKey="Forloni, Gianluigi" sort="Forloni, Gianluigi" uniqKey="Forloni G" first="Gianluigi" last="Forloni">Gianluigi Forloni</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano</wicri:regionArea></affiliation></author><author><name sortKey="Girtler, Nicola" sort="Girtler, Nicola" uniqKey="Girtler N" first="Nicola" last="Girtler">Nicola Girtler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuroscience (DINOGMI), Clinical Neurology, University of Genoa, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience (DINOGMI), Clinical Neurology, University of Genoa, Genoa</wicri:regionArea></affiliation></author><author><name sortKey="Hensch, Tilman" sort="Hensch, Tilman" uniqKey="Hensch T" first="Tilman" last="Hensch">Tilman Hensch</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="Jovicich, Jorge" sort="Jovicich, Jorge" uniqKey="Jovicich J" first="Jorge" last="Jovicich">Jorge Jovicich</name><affiliation wicri:level="1"><nlm:affiliation>Center for Mind/Brain Sciences, University of Trento, Rovereto, Trento, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Mind/Brain Sciences, University of Trento, Rovereto, Trento</wicri:regionArea></affiliation></author><author><name sortKey="Leeuwis, Annebet" sort="Leeuwis, Annebet" uniqKey="Leeuwis A" first="Annebet" last="Leeuwis">Annebet Leeuwis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Marra, Camillo" sort="Marra, Camillo" uniqKey="Marra C" first="Camillo" last="Marra">Camillo Marra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gerontology, Neurosciences and Orthopedics, Institute of Neurology, Catholic University, Policlinic A. Gemelli Foundation, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Gerontology, Neurosciences and Orthopedics, Institute of Neurology, Catholic University, Policlinic A. Gemelli Foundation, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Molinuevo, Jose Luis" sort="Molinuevo, Jose Luis" uniqKey="Molinuevo J" first="José Luis" last="Molinuevo">José Luis Molinuevo</name><affiliation wicri:level="1"><nlm:affiliation>Alzheimer's Disease Unit and Other Cognitive Disorders Unit, Hospital Clínic de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Alzheimer's Disease Unit and Other Cognitive Disorders Unit, Hospital Clínic de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya</wicri:regionArea></affiliation></author><author><name sortKey="Nobili, Flavio" sort="Nobili, Flavio" uniqKey="Nobili F" first="Flavio" last="Nobili">Flavio Nobili</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuroscience (DINOGMI), Clinical Neurology, University of Genoa, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience (DINOGMI), Clinical Neurology, University of Genoa, Genoa</wicri:regionArea></affiliation></author><author><name sortKey="Pariente, Jeremie" sort="Pariente, Jeremie" uniqKey="Pariente J" first="Jeremie" last="Pariente">Jeremie Pariente</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, Imagerie cérébrale et handicaps neurologiques UMR 825, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Imagerie cérébrale et handicaps neurologiques UMR 825, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Payoux, Pierre" sort="Payoux, Pierre" uniqKey="Payoux P" first="Pierre" last="Payoux">Pierre Payoux</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, Imagerie cérébrale et handicaps neurologiques UMR 825, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Imagerie cérébrale et handicaps neurologiques UMR 825, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Ranjeva, Jean Philippe" sort="Ranjeva, Jean Philippe" uniqKey="Ranjeva J" first="Jean-Philippe" last="Ranjeva">Jean-Philippe Ranjeva</name><affiliation wicri:level="1"><nlm:affiliation>Aix-Marseille Université, INSERM, INS UMR_S 1106, Marseille, France; Service de Neurologie et Neuropsychologie, APHM Hôpital Timone Adultes, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, INSERM, INS UMR_S 1106, Marseille, France; Service de Neurologie et Neuropsychologie, APHM Hôpital Timone Adultes, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Rolandi, Elena" sort="Rolandi, Elena" uniqKey="Rolandi E" first="Elena" last="Rolandi">Elena Rolandi</name><affiliation wicri:level="1"><nlm:affiliation>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia</wicri:regionArea></affiliation></author><author><name sortKey="Rossini, Paolo Maria" sort="Rossini, Paolo Maria" uniqKey="Rossini P" first="Paolo Maria" last="Rossini">Paolo Maria Rossini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gerontology, Neurosciences and Orthopedics, Institute of Neurology, Catholic University, Policlinic A. Gemelli Foundation, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Gerontology, Neurosciences and Orthopedics, Institute of Neurology, Catholic University, Policlinic A. Gemelli Foundation, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Schonknecht, Peter" sort="Schonknecht, Peter" uniqKey="Schonknecht P" first="Peter" last="Schönknecht">Peter Schönknecht</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="Soricelli, Andrea" sort="Soricelli, Andrea" uniqKey="Soricelli A" first="Andrea" last="Soricelli">Andrea Soricelli</name><affiliation wicri:level="1"><nlm:affiliation>SDN Istituto di Ricerca Diagnostica e Nucleare, Napoli, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>SDN Istituto di Ricerca Diagnostica e Nucleare, Napoli</wicri:regionArea></affiliation></author><author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name><affiliation wicri:level="1"><nlm:affiliation>3rd Neurologic Clinic, Medical School, G. Papanikolaou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>3rd Neurologic Clinic, Medical School, G. Papanikolaou Hospital, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea></affiliation></author><author><name sortKey="Visser, Pieter Jelle" sort="Visser, Pieter Jelle" uniqKey="Visser P" first="Pieter Jelle" last="Visser">Pieter Jelle Visser</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Wiltfang, Jens" sort="Wiltfang, Jens" uniqKey="Wiltfang J" first="Jens" last="Wiltfang">Jens Wiltfang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, LVR-Hospital Essen, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August-University, Goettingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, LVR-Hospital Essen, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August-University, Goettingen</wicri:regionArea></affiliation></author><author><name sortKey="Richardson, Jill C" sort="Richardson, Jill C" uniqKey="Richardson J" first="Jill C" last="Richardson">Jill C. Richardson</name><affiliation wicri:level="1"><nlm:affiliation>Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage</wicri:regionArea></affiliation></author><author><name sortKey="Bordet, Regis" sort="Bordet, Regis" uniqKey="Bordet R" first="Régis" last="Bordet">Régis Bordet</name><affiliation wicri:level="1"><nlm:affiliation>University of Lille, Inserm, CHU Lille, U1171 - Degenerative and Vascular Cognitive Disorders, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lille, Inserm, CHU Lille, U1171 - Degenerative and Vascular Cognitive Disorders, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Blin, Olivier" sort="Blin, Olivier" uniqKey="Blin O" first="Olivier" last="Blin">Olivier Blin</name><affiliation wicri:level="1"><nlm:affiliation>Mediterranean Institute of Cognitive Neurosciences (INCM), UMR-CNRS (6193), Aix Marseille University, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Mediterranean Institute of Cognitive Neurosciences (INCM), UMR-CNRS (6193), Aix Marseille University, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Frisoni, Giovanni B" sort="Frisoni, Giovanni B" uniqKey="Frisoni G" first="Giovanni B" last="Frisoni">Giovanni B. Frisoni</name><affiliation wicri:level="1"><nlm:affiliation>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28189924</idno><idno type="pmid">28189924</idno><idno type="doi">10.1016/j.neurobiolaging.2017.01.013</idno><idno type="wicri:Area/PubMed/Corpus">000C48</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C48</idno><idno type="wicri:Area/PubMed/Curation">000C45</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C45</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI).</title><author><name sortKey="Nathan, Pradeep J" sort="Nathan, Pradeep J" uniqKey="Nathan P" first="Pradeep J" last="Nathan">Pradeep J. Nathan</name><affiliation wicri:level="1"><nlm:affiliation>Heptares Therapeutics Ltd, Cambridge, UK; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK. Electronic address: pradeep.nathan@heptares.com.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Heptares Therapeutics Ltd, Cambridge, UK; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Lim, Yen Ying" sort="Lim, Yen Ying" uniqKey="Lim Y" first="Yen Ying" last="Lim">Yen Ying Lim</name><affiliation wicri:level="1"><nlm:affiliation>The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia. Electronic address: yen.lim@florey.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Abbott, Rosemary" sort="Abbott, Rosemary" uniqKey="Abbott R" first="Rosemary" last="Abbott">Rosemary Abbott</name><affiliation wicri:level="1"><nlm:affiliation>Cambridge Cognition, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge Cognition, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Galluzzi, Samantha" sort="Galluzzi, Samantha" uniqKey="Galluzzi S" first="Samantha" last="Galluzzi">Samantha Galluzzi</name><affiliation wicri:level="1"><nlm:affiliation>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia</wicri:regionArea></affiliation></author><author><name sortKey="Marizzoni, Moira" sort="Marizzoni, Moira" uniqKey="Marizzoni M" first="Moira" last="Marizzoni">Moira Marizzoni</name><affiliation wicri:level="1"><nlm:affiliation>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia</wicri:regionArea></affiliation></author><author><name sortKey="Babiloni, Claudio" sort="Babiloni, Claudio" uniqKey="Babiloni C" first="Claudio" last="Babiloni">Claudio Babiloni</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy; IRCCS San Raffaele Pisana of Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy; IRCCS San Raffaele Pisana of Rome</wicri:regionArea></affiliation></author><author><name sortKey="Albani, Diego" sort="Albani, Diego" uniqKey="Albani D" first="Diego" last="Albani">Diego Albani</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano</wicri:regionArea></affiliation></author><author><name sortKey="Bartres Faz, David" sort="Bartres Faz, David" uniqKey="Bartres Faz D" first="David" last="Bartres-Faz">David Bartres-Faz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya</wicri:regionArea></affiliation></author><author><name sortKey="Didic, Mira" sort="Didic, Mira" uniqKey="Didic M" first="Mira" last="Didic">Mira Didic</name><affiliation wicri:level="1"><nlm:affiliation>Aix-Marseille Université, INSERM, INS UMR_S 1106, Marseille, France; Service de Neurologie et Neuropsychologie, APHM Hôpital Timone Adultes, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, INSERM, INS UMR_S 1106, Marseille, France; Service de Neurologie et Neuropsychologie, APHM Hôpital Timone Adultes, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Farotti, Lucia" sort="Farotti, Lucia" uniqKey="Farotti L" first="Lucia" last="Farotti">Lucia Farotti</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Neurologica, Centro Disturbi della Memoria, Università di Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Neurologica, Centro Disturbi della Memoria, Università di Perugia, Ospedale Santa Maria della Misericordia, Perugia</wicri:regionArea></affiliation></author><author><name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Neurologica, Centro Disturbi della Memoria, Università di Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Neurologica, Centro Disturbi della Memoria, Università di Perugia, Ospedale Santa Maria della Misericordia, Perugia</wicri:regionArea></affiliation></author><author><name sortKey="Salvadori, Nicola" sort="Salvadori, Nicola" uniqKey="Salvadori N" first="Nicola" last="Salvadori">Nicola Salvadori</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Neurologica, Centro Disturbi della Memoria, Università di Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Neurologica, Centro Disturbi della Memoria, Università di Perugia, Ospedale Santa Maria della Misericordia, Perugia</wicri:regionArea></affiliation></author><author><name sortKey="Muller, Bernhard W" sort="Muller, Bernhard W" uniqKey="Muller B" first="Bernhard W" last="Müller">Bernhard W. Müller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, LVR-Hospital Essen, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, LVR-Hospital Essen, Faculty of Medicine, University of Duisburg-Essen, Essen</wicri:regionArea></affiliation></author><author><name sortKey="Forloni, Gianluigi" sort="Forloni, Gianluigi" uniqKey="Forloni G" first="Gianluigi" last="Forloni">Gianluigi Forloni</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano</wicri:regionArea></affiliation></author><author><name sortKey="Girtler, Nicola" sort="Girtler, Nicola" uniqKey="Girtler N" first="Nicola" last="Girtler">Nicola Girtler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuroscience (DINOGMI), Clinical Neurology, University of Genoa, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience (DINOGMI), Clinical Neurology, University of Genoa, Genoa</wicri:regionArea></affiliation></author><author><name sortKey="Hensch, Tilman" sort="Hensch, Tilman" uniqKey="Hensch T" first="Tilman" last="Hensch">Tilman Hensch</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="Jovicich, Jorge" sort="Jovicich, Jorge" uniqKey="Jovicich J" first="Jorge" last="Jovicich">Jorge Jovicich</name><affiliation wicri:level="1"><nlm:affiliation>Center for Mind/Brain Sciences, University of Trento, Rovereto, Trento, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Mind/Brain Sciences, University of Trento, Rovereto, Trento</wicri:regionArea></affiliation></author><author><name sortKey="Leeuwis, Annebet" sort="Leeuwis, Annebet" uniqKey="Leeuwis A" first="Annebet" last="Leeuwis">Annebet Leeuwis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Marra, Camillo" sort="Marra, Camillo" uniqKey="Marra C" first="Camillo" last="Marra">Camillo Marra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gerontology, Neurosciences and Orthopedics, Institute of Neurology, Catholic University, Policlinic A. Gemelli Foundation, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Gerontology, Neurosciences and Orthopedics, Institute of Neurology, Catholic University, Policlinic A. Gemelli Foundation, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Molinuevo, Jose Luis" sort="Molinuevo, Jose Luis" uniqKey="Molinuevo J" first="José Luis" last="Molinuevo">José Luis Molinuevo</name><affiliation wicri:level="1"><nlm:affiliation>Alzheimer's Disease Unit and Other Cognitive Disorders Unit, Hospital Clínic de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Alzheimer's Disease Unit and Other Cognitive Disorders Unit, Hospital Clínic de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya</wicri:regionArea></affiliation></author><author><name sortKey="Nobili, Flavio" sort="Nobili, Flavio" uniqKey="Nobili F" first="Flavio" last="Nobili">Flavio Nobili</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuroscience (DINOGMI), Clinical Neurology, University of Genoa, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience (DINOGMI), Clinical Neurology, University of Genoa, Genoa</wicri:regionArea></affiliation></author><author><name sortKey="Pariente, Jeremie" sort="Pariente, Jeremie" uniqKey="Pariente J" first="Jeremie" last="Pariente">Jeremie Pariente</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, Imagerie cérébrale et handicaps neurologiques UMR 825, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Imagerie cérébrale et handicaps neurologiques UMR 825, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Payoux, Pierre" sort="Payoux, Pierre" uniqKey="Payoux P" first="Pierre" last="Payoux">Pierre Payoux</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, Imagerie cérébrale et handicaps neurologiques UMR 825, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Imagerie cérébrale et handicaps neurologiques UMR 825, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Ranjeva, Jean Philippe" sort="Ranjeva, Jean Philippe" uniqKey="Ranjeva J" first="Jean-Philippe" last="Ranjeva">Jean-Philippe Ranjeva</name><affiliation wicri:level="1"><nlm:affiliation>Aix-Marseille Université, INSERM, INS UMR_S 1106, Marseille, France; Service de Neurologie et Neuropsychologie, APHM Hôpital Timone Adultes, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, INSERM, INS UMR_S 1106, Marseille, France; Service de Neurologie et Neuropsychologie, APHM Hôpital Timone Adultes, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Rolandi, Elena" sort="Rolandi, Elena" uniqKey="Rolandi E" first="Elena" last="Rolandi">Elena Rolandi</name><affiliation wicri:level="1"><nlm:affiliation>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia</wicri:regionArea></affiliation></author><author><name sortKey="Rossini, Paolo Maria" sort="Rossini, Paolo Maria" uniqKey="Rossini P" first="Paolo Maria" last="Rossini">Paolo Maria Rossini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gerontology, Neurosciences and Orthopedics, Institute of Neurology, Catholic University, Policlinic A. Gemelli Foundation, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Gerontology, Neurosciences and Orthopedics, Institute of Neurology, Catholic University, Policlinic A. Gemelli Foundation, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Schonknecht, Peter" sort="Schonknecht, Peter" uniqKey="Schonknecht P" first="Peter" last="Schönknecht">Peter Schönknecht</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="Soricelli, Andrea" sort="Soricelli, Andrea" uniqKey="Soricelli A" first="Andrea" last="Soricelli">Andrea Soricelli</name><affiliation wicri:level="1"><nlm:affiliation>SDN Istituto di Ricerca Diagnostica e Nucleare, Napoli, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>SDN Istituto di Ricerca Diagnostica e Nucleare, Napoli</wicri:regionArea></affiliation></author><author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name><affiliation wicri:level="1"><nlm:affiliation>3rd Neurologic Clinic, Medical School, G. Papanikolaou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>3rd Neurologic Clinic, Medical School, G. Papanikolaou Hospital, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea></affiliation></author><author><name sortKey="Visser, Pieter Jelle" sort="Visser, Pieter Jelle" uniqKey="Visser P" first="Pieter Jelle" last="Visser">Pieter Jelle Visser</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Wiltfang, Jens" sort="Wiltfang, Jens" uniqKey="Wiltfang J" first="Jens" last="Wiltfang">Jens Wiltfang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, LVR-Hospital Essen, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August-University, Goettingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, LVR-Hospital Essen, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August-University, Goettingen</wicri:regionArea></affiliation></author><author><name sortKey="Richardson, Jill C" sort="Richardson, Jill C" uniqKey="Richardson J" first="Jill C" last="Richardson">Jill C. Richardson</name><affiliation wicri:level="1"><nlm:affiliation>Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage</wicri:regionArea></affiliation></author><author><name sortKey="Bordet, Regis" sort="Bordet, Regis" uniqKey="Bordet R" first="Régis" last="Bordet">Régis Bordet</name><affiliation wicri:level="1"><nlm:affiliation>University of Lille, Inserm, CHU Lille, U1171 - Degenerative and Vascular Cognitive Disorders, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lille, Inserm, CHU Lille, U1171 - Degenerative and Vascular Cognitive Disorders, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Blin, Olivier" sort="Blin, Olivier" uniqKey="Blin O" first="Olivier" last="Blin">Olivier Blin</name><affiliation wicri:level="1"><nlm:affiliation>Mediterranean Institute of Cognitive Neurosciences (INCM), UMR-CNRS (6193), Aix Marseille University, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Mediterranean Institute of Cognitive Neurosciences (INCM), UMR-CNRS (6193), Aix Marseille University, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Frisoni, Giovanni B" sort="Frisoni, Giovanni B" uniqKey="Frisoni G" first="Giovanni B" last="Frisoni">Giovanni B. Frisoni</name><affiliation wicri:level="1"><nlm:affiliation>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva</wicri:regionArea></affiliation></author></analytic><series><title level="j">Neurobiology of aging</title><idno type="eISSN">1558-1497</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Few studies have examined the relationship between CSF and structural biomarkers, and cognitive function in MCI. We examined the relationship between cognitive function, hippocampal volume and cerebrospinal fluid (CSF) Aβ42 and tau in 145 patients with MCI. Patients were assessed on cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), the Geriatric Depression Scale and the Functional Activities Questionnaire. Hippocampal volume was measured using magnetic resonance imaging (MRI), and CSF markers of Aβ42, tau and p-tau181 were also measured. Worse performance on a wide range of memory and sustained attention tasks were associated with reduced hippocampal volume, higher CSF tau and p-tau181 and increased tau/Aβ42 ratio. Memory tasks were also associated with lower ability to conduct functional activities of daily living, providing a link between AD biomarkers, memory performance and functional outcome. These results suggest that biomarkers of Aβ and tau are strongly related to cognitive performance as assessed by the CANTAB, and have implications for the early detection and characterization of incipient AD.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28189924</PMID><DateCreated><Year>2017</Year><Month>02</Month><Day>12</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1558-1497</ISSN><JournalIssue CitedMedium="Internet"><Volume>53</Volume><PubDate><Year>2017</Year><Month>05</Month></PubDate></JournalIssue><Title>Neurobiology of aging</Title><ISOAbbreviation>Neurobiol. Aging</ISOAbbreviation></Journal><ArticleTitle>Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI).</ArticleTitle><Pagination><MedlinePgn>1-10</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0197-4580(17)30021-0</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neurobiolaging.2017.01.013</ELocationID><Abstract><AbstractText>Few studies have examined the relationship between CSF and structural biomarkers, and cognitive function in MCI. We examined the relationship between cognitive function, hippocampal volume and cerebrospinal fluid (CSF) Aβ42 and tau in 145 patients with MCI. Patients were assessed on cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), the Geriatric Depression Scale and the Functional Activities Questionnaire. Hippocampal volume was measured using magnetic resonance imaging (MRI), and CSF markers of Aβ42, tau and p-tau181 were also measured. Worse performance on a wide range of memory and sustained attention tasks were associated with reduced hippocampal volume, higher CSF tau and p-tau181 and increased tau/Aβ42 ratio. Memory tasks were also associated with lower ability to conduct functional activities of daily living, providing a link between AD biomarkers, memory performance and functional outcome. These results suggest that biomarkers of Aβ and tau are strongly related to cognitive performance as assessed by the CANTAB, and have implications for the early detection and characterization of incipient AD.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nathan</LastName><ForeName>Pradeep J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Heptares Therapeutics Ltd, Cambridge, UK; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK. Electronic address: pradeep.nathan@heptares.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Yen Ying</ForeName><Initials>YY</Initials><AffiliationInfo><Affiliation>The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia. Electronic address: yen.lim@florey.edu.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abbott</LastName><ForeName>Rosemary</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Cambridge Cognition, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Galluzzi</LastName><ForeName>Samantha</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marizzoni</LastName><ForeName>Moira</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Babiloni</LastName><ForeName>Claudio</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy; IRCCS San Raffaele Pisana of Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Albani</LastName><ForeName>Diego</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bartres-Faz</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Didic</LastName><ForeName>Mira</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Aix-Marseille Université, INSERM, INS UMR_S 1106, Marseille, France; Service de Neurologie et Neuropsychologie, APHM Hôpital Timone Adultes, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farotti</LastName><ForeName>Lucia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Clinica Neurologica, Centro Disturbi della Memoria, Università di Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parnetti</LastName><ForeName>Lucilla</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Clinica Neurologica, Centro Disturbi della Memoria, Università di Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salvadori</LastName><ForeName>Nicola</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Clinica Neurologica, Centro Disturbi della Memoria, Università di Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Müller</LastName><ForeName>Bernhard W</ForeName><Initials>BW</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, LVR-Hospital Essen, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Forloni</LastName><ForeName>Gianluigi</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Girtler</LastName><ForeName>Nicola</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Neuroscience (DINOGMI), Clinical Neurology, University of Genoa, Genoa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hensch</LastName><ForeName>Tilman</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jovicich</LastName><ForeName>Jorge</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Center for Mind/Brain Sciences, University of Trento, Rovereto, Trento, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leeuwis</LastName><ForeName>Annebet</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marra</LastName><ForeName>Camillo</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Gerontology, Neurosciences and Orthopedics, Institute of Neurology, Catholic University, Policlinic A. Gemelli Foundation, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Molinuevo</LastName><ForeName>José Luis</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Alzheimer's Disease Unit and Other Cognitive Disorders Unit, Hospital Clínic de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nobili</LastName><ForeName>Flavio</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Neuroscience (DINOGMI), Clinical Neurology, University of Genoa, Genoa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pariente</LastName><ForeName>Jeremie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>INSERM, Imagerie cérébrale et handicaps neurologiques UMR 825, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Payoux</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>INSERM, Imagerie cérébrale et handicaps neurologiques UMR 825, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ranjeva</LastName><ForeName>Jean-Philippe</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Aix-Marseille Université, INSERM, INS UMR_S 1106, Marseille, France; Service de Neurologie et Neuropsychologie, APHM Hôpital Timone Adultes, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rolandi</LastName><ForeName>Elena</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rossini</LastName><ForeName>Paolo Maria</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Department of Gerontology, Neurosciences and Orthopedics, Institute of Neurology, Catholic University, Policlinic A. Gemelli Foundation, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schönknecht</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soricelli</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>SDN Istituto di Ricerca Diagnostica e Nucleare, Napoli, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsolaki</LastName><ForeName>Magda</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>3rd Neurologic Clinic, Medical School, G. Papanikolaou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Visser</LastName><ForeName>Pieter Jelle</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wiltfang</LastName><ForeName>Jens</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, LVR-Hospital Essen, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August-University, Goettingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richardson</LastName><ForeName>Jill C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bordet</LastName><ForeName>Régis</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>University of Lille, Inserm, CHU Lille, U1171 - Degenerative and Vascular Cognitive Disorders, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blin</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Mediterranean Institute of Cognitive Neurosciences (INCM), UMR-CNRS (6193), Aix Marseille University, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frisoni</LastName><ForeName>Giovanni B</ForeName><Initials>GB</Initials><AffiliationInfo><Affiliation>Lab Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>PharmaCog Consortium</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>01</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurobiol Aging</MedlineTA><NlmUniqueID>8100437</NlmUniqueID><ISSNLinking>0197-4580</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Alzheimer's disease</Keyword><Keyword MajorTopicYN="Y">Amyloid</Keyword><Keyword MajorTopicYN="Y">CANTAB</Keyword><Keyword MajorTopicYN="Y">CSF</Keyword><Keyword MajorTopicYN="Y">Cognitive assessment</Keyword><Keyword MajorTopicYN="Y">Hippocampal volume</Keyword><Keyword MajorTopicYN="Y">Mild cognitive impairment</Keyword><Keyword MajorTopicYN="Y">Prodromal</Keyword><Keyword MajorTopicYN="Y">Tau</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>08</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>01</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>01</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28189924</ArticleId><ArticleId IdType="pii">S0197-4580(17)30021-0</ArticleId><ArticleId IdType="doi">10.1016/j.neurobiolaging.2017.01.013</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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