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Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis.

Identifieur interne : 000A63 ( PubMed/Curation ); précédent : 000A62; suivant : 000A64

Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis.

Auteurs : Tobias J. Weismüller [Allemagne] ; Palak J. Trivedi [Royaume-Uni] ; Annika Bergquist [Suède] ; Mohamad Imam [États-Unis] ; Henrike Lenzen [Allemagne] ; Cyriel Y. Ponsioen [Pays-Bas] ; Kristian Holm [Norvège] ; Daniel Gotthardt [Allemagne] ; Martti A. F Rkkil [Finlande] ; Hanns-Ulrich Marschall [Suède] ; Douglas Thorburn [Royaume-Uni] ; Rinse K. Weersma [Pays-Bas] ; Johan Fevery [Belgique] ; Tobias Mueller [Allemagne] ; Olivier Chazouillères [France] ; Kornelius Schulze [Allemagne] ; Konstantinos N. Lazaridis [États-Unis] ; Sven Almer ; Stephen P. Pereira [Royaume-Uni] ; Cynthia Levy [États-Unis] ; Andrew Mason [Canada] ; Sigrid Naess [Norvège] ; Christopher L. Bowlus [États-Unis] ; Annarosa Floreani [Italie] ; Emina Halilbasic [Autriche] ; Kidist K. Yimam [États-Unis] ; Piotr Milkiewicz [Pologne] ; Ulrich Beuers [Pays-Bas] ; Dep K. Huynh [Australie] ; Albert Pares [Espagne] ; Christine N. Manser [Suisse] ; George N. Dalekos [Grèce] ; Bertus Eksteen [Canada] ; Pietro Invernizzi [Italie] ; Christoph P. Berg [Allemagne] ; Gabi I. Kirchner [Allemagne] ; Christoph Sarrazin [Allemagne] ; Vincent Zimmer [Allemagne] ; Luca Fabris [Italie] ; Felix Braun [Allemagne] ; Marco Marzioni [Italie] ; Brian D. Juran [États-Unis] ; Karouk Said [Suède] ; Christian Rupp [Allemagne] ; Kalle Jokelainen [Finlande] ; Maria Benito De Valle [Suède] ; Francesca Saffioti [Royaume-Uni] ; Angela Cheung [États-Unis] ; Michael Trauner [Autriche] ; Christoph Schramm [Allemagne] ; Roger W. Chapman [Royaume-Uni] ; Tom H. Karlsen [Norvège] ; Erik Schrumpf [Norvège] ; Christian P. Strassburg [Allemagne] ; Michael P. Manns [Allemagne] ; Keith D. Lindor [États-Unis] ; Gideon M. Hirschfield [Royaume-Uni] ; Bettina E. Hansen [Canada] ; Kirsten M. Boberg [Norvège]

Source :

RBID : pubmed:28274849

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Abstract

Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of disease progression based on distinct clinical phenotypes in a large international cohort of patients with PSC.

DOI: 10.1053/j.gastro.2017.02.038
PubMed: 28274849

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pubmed:28274849

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Sven Almer
<affiliation>
<nlm:affiliation>Division of Gastroenterology and Hepatology, Linköping University, Linköping; Sweden.</nlm:affiliation>
<wicri:noCountry code="subField">Linköping; Sweden</wicri:noCountry>
</affiliation>

Le document en format XML

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<title xml:lang="en">Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis.</title>
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<name sortKey="Weismuller, Tobias J" sort="Weismuller, Tobias J" uniqKey="Weismuller T" first="Tobias J" last="Weismüller">Tobias J. Weismüller</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine I, University of Bonn, Germany; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. Electronic address: tobias.weismueller@gmx.de.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine I, University of Bonn, Germany; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover</wicri:regionArea>
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<name sortKey="Trivedi, Palak J" sort="Trivedi, Palak J" uniqKey="Trivedi P" first="Palak J" last="Trivedi">Palak J. Trivedi</name>
<affiliation wicri:level="1">
<nlm:affiliation>National Institute for Health Research (NIHR) Birmingham, Liver Biomedical Research Centre (BRC), University of Birmingham, United Kingdom; Liver Unit, University Hospitals Birmingham Queen Elizabeth, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Institute for Health Research (NIHR) Birmingham, Liver Biomedical Research Centre (BRC), University of Birmingham, United Kingdom; Liver Unit, University Hospitals Birmingham Queen Elizabeth</wicri:regionArea>
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<name sortKey="Bergquist, Annika" sort="Bergquist, Annika" uniqKey="Bergquist A" first="Annika" last="Bergquist">Annika Bergquist</name>
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<nlm:affiliation>Center for Digestive Diseases, Division of Hepatology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Center for Digestive Diseases, Division of Hepatology, Karolinska University Hospital and Karolinska Institutet, Stockholm</wicri:regionArea>
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<name sortKey="Imam, Mohamad" sort="Imam, Mohamad" uniqKey="Imam M" first="Mohamad" last="Imam">Mohamad Imam</name>
<affiliation wicri:level="2">
<nlm:affiliation>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Department of Internal Medicine, University of North Dakota, Grand Forks, North Dakota.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Dakota du Nord</region>
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<wicri:cityArea>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Department of Internal Medicine, University of North Dakota, Grand Forks</wicri:cityArea>
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<name sortKey="Lenzen, Henrike" sort="Lenzen, Henrike" uniqKey="Lenzen H" first="Henrike" last="Lenzen">Henrike Lenzen</name>
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<nlm:affiliation>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover</wicri:regionArea>
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<name sortKey="Ponsioen, Cyriel Y" sort="Ponsioen, Cyriel Y" uniqKey="Ponsioen C" first="Cyriel Y" last="Ponsioen">Cyriel Y. Ponsioen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam</wicri:regionArea>
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<name sortKey="Holm, Kristian" sort="Holm, Kristian" uniqKey="Holm K" first="Kristian" last="Holm">Kristian Holm</name>
<affiliation wicri:level="1">
<nlm:affiliation>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo</wicri:regionArea>
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<author>
<name sortKey="Gotthardt, Daniel" sort="Gotthardt, Daniel" uniqKey="Gotthardt D" first="Daniel" last="Gotthardt">Daniel Gotthardt</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology, Infectious Diseases and Intoxications, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gastroenterology, Infectious Diseases and Intoxications, University Hospital Heidelberg, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="F Rkkil, Martti A" sort="F Rkkil, Martti A" uniqKey="F Rkkil M" first="Martti A" last="F Rkkil">Martti A. F Rkkil</name>
<affiliation wicri:level="1">
<nlm:affiliation>Helsinki University, Clinic of Gastroenterology, Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Helsinki University, Clinic of Gastroenterology, Helsinki University Hospital, Helsinki</wicri:regionArea>
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<author>
<name sortKey="Marschall, Hanns Ulrich" sort="Marschall, Hanns Ulrich" uniqKey="Marschall H" first="Hanns-Ulrich" last="Marschall">Hanns-Ulrich Marschall</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg</wicri:regionArea>
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<author>
<name sortKey="Thorburn, Douglas" sort="Thorburn, Douglas" uniqKey="Thorburn D" first="Douglas" last="Thorburn">Douglas Thorburn</name>
<affiliation wicri:level="1">
<nlm:affiliation>The Sheila Sherlock Liver Centre and UCL Institute for Liver and Digestive Health, Royal Free Hospital, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sheila Sherlock Liver Centre and UCL Institute for Liver and Digestive Health, Royal Free Hospital, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Weersma, Rinse K" sort="Weersma, Rinse K" uniqKey="Weersma R" first="Rinse K" last="Weersma">Rinse K. Weersma</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center, Groningen, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center, Groningen</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fevery, Johan" sort="Fevery, Johan" uniqKey="Fevery J" first="Johan" last="Fevery">Johan Fevery</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Hepatology, University Hospital Gasthuisberg, Leuven</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mueller, Tobias" sort="Mueller, Tobias" uniqKey="Mueller T" first="Tobias" last="Mueller">Tobias Mueller</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine, Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chazouilleres, Olivier" sort="Chazouilleres, Olivier" uniqKey="Chazouilleres O" first="Olivier" last="Chazouillères">Olivier Chazouillères</name>
<affiliation wicri:level="1">
<nlm:affiliation>Service d'Hépatologie, Hôpital Saint Antoine, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine Pierre et Marie Curie, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service d'Hépatologie, Hôpital Saint Antoine, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine Pierre et Marie Curie, Paris</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schulze, Kornelius" sort="Schulze, Kornelius" uniqKey="Schulze K" first="Kornelius" last="Schulze">Kornelius Schulze</name>
<affiliation wicri:level="1">
<nlm:affiliation>1st Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>1st Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lazaridis, Konstantinos N" sort="Lazaridis, Konstantinos N" uniqKey="Lazaridis K" first="Konstantinos N" last="Lazaridis">Konstantinos N. Lazaridis</name>
<affiliation wicri:level="2">
<nlm:affiliation>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Almer, Sven" sort="Almer, Sven" uniqKey="Almer S" first="Sven" last="Almer">Sven Almer</name>
<affiliation>
<nlm:affiliation>Division of Gastroenterology and Hepatology, Linköping University, Linköping; Sweden.</nlm:affiliation>
<wicri:noCountry code="subField">Linköping; Sweden</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Pereira, Stephen P" sort="Pereira, Stephen P" uniqKey="Pereira S" first="Stephen P" last="Pereira">Stephen P. Pereira</name>
<affiliation wicri:level="1">
<nlm:affiliation>Institute for Liver and Digestive Health, University College London, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute for Liver and Digestive Health, University College London, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Levy, Cynthia" sort="Levy, Cynthia" uniqKey="Levy C" first="Cynthia" last="Levy">Cynthia Levy</name>
<affiliation wicri:level="2">
<nlm:affiliation>Division of Hepatology, University of Miami, Miami, Florida.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Floride</region>
</placeName>
<wicri:cityArea>Division of Hepatology, University of Miami, Miami</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Mason, Andrew" sort="Mason, Andrew" uniqKey="Mason A" first="Andrew" last="Mason">Andrew Mason</name>
<affiliation wicri:level="1">
<nlm:affiliation>Division of Gastroenterology and Hepatology, University of Alberta, Edmonton, AB, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Gastroenterology and Hepatology, University of Alberta, Edmonton, AB</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Naess, Sigrid" sort="Naess, Sigrid" uniqKey="Naess S" first="Sigrid" last="Naess">Sigrid Naess</name>
<affiliation wicri:level="1">
<nlm:affiliation>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bowlus, Christopher L" sort="Bowlus, Christopher L" uniqKey="Bowlus C" first="Christopher L" last="Bowlus">Christopher L. Bowlus</name>
<affiliation wicri:level="2">
<nlm:affiliation>Division of Gastroenterology and Hepatology, University of California Davis, Davis, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName>
<region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Gastroenterology and Hepatology, University of California Davis, Davis</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Floreani, Annarosa" sort="Floreani, Annarosa" uniqKey="Floreani A" first="Annarosa" last="Floreani">Annarosa Floreani</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Halilbasic, Emina" sort="Halilbasic, Emina" uniqKey="Halilbasic E" first="Emina" last="Halilbasic">Emina Halilbasic</name>
<affiliation wicri:level="1">
<nlm:affiliation>Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Yimam, Kidist K" sort="Yimam, Kidist K" uniqKey="Yimam K" first="Kidist K" last="Yimam">Kidist K. Yimam</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Hepatology and Liver Transplantation, California Pacific Medical Center, San Francisco, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName>
<region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Hepatology and Liver Transplantation, California Pacific Medical Center, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Milkiewicz, Piotr" sort="Milkiewicz, Piotr" uniqKey="Milkiewicz P" first="Piotr" last="Milkiewicz">Piotr Milkiewicz</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin, Poland; Liver and Internal Medicine Unit, Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin, Poland; Liver and Internal Medicine Unit, Department of General, Transplant and Liver Surgery, Medical University of Warsaw</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Beuers, Ulrich" sort="Beuers, Ulrich" uniqKey="Beuers U" first="Ulrich" last="Beuers">Ulrich Beuers</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Huynh, Dep K" sort="Huynh, Dep K" uniqKey="Huynh D" first="Dep K" last="Huynh">Dep K. Huynh</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, SA, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, SA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Pares, Albert" sort="Pares, Albert" uniqKey="Pares A" first="Albert" last="Pares">Albert Pares</name>
<affiliation wicri:level="1">
<nlm:affiliation>Liver Unit, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Liver Unit, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Manser, Christine N" sort="Manser, Christine N" uniqKey="Manser C" first="Christine N" last="Manser">Christine N. Manser</name>
<affiliation wicri:level="1">
<nlm:affiliation>Division for Gastroenterology and Hepatology, University Hospital Zurich (USZ), Zurich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Division for Gastroenterology and Hepatology, University Hospital Zurich (USZ), Zurich</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Dalekos, George N" sort="Dalekos, George N" uniqKey="Dalekos G" first="George N" last="Dalekos">George N. Dalekos</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medicine and Research Laboratory of Internal Medicine, School of Medicine, University of Thessaly, Larissa, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Medicine and Research Laboratory of Internal Medicine, School of Medicine, University of Thessaly, Larissa</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Eksteen, Bertus" sort="Eksteen, Bertus" uniqKey="Eksteen B" first="Bertus" last="Eksteen">Bertus Eksteen</name>
<affiliation wicri:level="1">
<nlm:affiliation>University of Calgary, Snyder Institute for Chronic Diseases, Alberta, AB, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of Calgary, Snyder Institute for Chronic Diseases, Alberta, AB</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Invernizzi, Pietro" sort="Invernizzi, Pietro" uniqKey="Invernizzi P" first="Pietro" last="Invernizzi">Pietro Invernizzi</name>
<affiliation wicri:level="1">
<nlm:affiliation>Program for Autoimmune Liver Diseases, International Center for Digestive Health, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Program for Autoimmune Liver Diseases, International Center for Digestive Health, Department of Medicine and Surgery, University of Milan-Bicocca, Milan</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Berg, Christoph P" sort="Berg, Christoph P" uniqKey="Berg C" first="Christoph P" last="Berg">Christoph P. Berg</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology, Hepatology, and Infectiology, Medical Clinic, University of Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gastroenterology, Hepatology, and Infectiology, Medical Clinic, University of Tübingen</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kirchner, Gabi I" sort="Kirchner, Gabi I" uniqKey="Kirchner G" first="Gabi I" last="Kirchner">Gabi I. Kirchner</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine 1, University Hospital of Regensburg, Regensburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine 1, University Hospital of Regensburg, Regensburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sarrazin, Christoph" sort="Sarrazin, Christoph" uniqKey="Sarrazin C" first="Christoph" last="Sarrazin">Christoph Sarrazin</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine 1, Johann Wolfgang Goethe-University Hospital, Frankfurt, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine 1, Johann Wolfgang Goethe-University Hospital, Frankfurt</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Zimmer, Vincent" sort="Zimmer, Vincent" uniqKey="Zimmer V" first="Vincent" last="Zimmer">Vincent Zimmer</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medicine II, Saarland University Medical Center, Homburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medicine II, Saarland University Medical Center, Homburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fabris, Luca" sort="Fabris, Luca" uniqKey="Fabris L" first="Luca" last="Fabris">Luca Fabris</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Molecular Medicine, University of Padua School of Medicine, Padua, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Molecular Medicine, University of Padua School of Medicine, Padua</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Braun, Felix" sort="Braun, Felix" uniqKey="Braun F" first="Felix" last="Braun">Felix Braun</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of General, Visceral, Thoracic, Transplantation and Pediatric Surgery, Campus Kiel, UKSH, Kiel, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of General, Visceral, Thoracic, Transplantation and Pediatric Surgery, Campus Kiel, UKSH, Kiel</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Marzioni, Marco" sort="Marzioni, Marco" uniqKey="Marzioni M" first="Marco" last="Marzioni">Marco Marzioni</name>
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<nlm:affiliation>Clinic of Gastroenterology, Università Politecnica delle Marche, Ancona, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Clinic of Gastroenterology, Università Politecnica delle Marche, Ancona</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Juran, Brian D" sort="Juran, Brian D" uniqKey="Juran B" first="Brian D" last="Juran">Brian D. Juran</name>
<affiliation wicri:level="2">
<nlm:affiliation>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Said, Karouk" sort="Said, Karouk" uniqKey="Said K" first="Karouk" last="Said">Karouk Said</name>
<affiliation wicri:level="1">
<nlm:affiliation>Center for Digestive Diseases, Division of Hepatology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Center for Digestive Diseases, Division of Hepatology, Karolinska University Hospital and Karolinska Institutet, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rupp, Christian" sort="Rupp, Christian" uniqKey="Rupp C" first="Christian" last="Rupp">Christian Rupp</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology, Infectious Diseases and Intoxications, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gastroenterology, Infectious Diseases and Intoxications, University Hospital Heidelberg, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jokelainen, Kalle" sort="Jokelainen, Kalle" uniqKey="Jokelainen K" first="Kalle" last="Jokelainen">Kalle Jokelainen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Helsinki University, Clinic of Gastroenterology, Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Helsinki University, Clinic of Gastroenterology, Helsinki University Hospital, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Benito De Valle, Maria" sort="Benito De Valle, Maria" uniqKey="Benito De Valle M" first="Maria" last="Benito De Valle">Maria Benito De Valle</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Saffioti, Francesca" sort="Saffioti, Francesca" uniqKey="Saffioti F" first="Francesca" last="Saffioti">Francesca Saffioti</name>
<affiliation wicri:level="1">
<nlm:affiliation>The Sheila Sherlock Liver Centre and UCL Institute for Liver and Digestive Health, Royal Free Hospital, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sheila Sherlock Liver Centre and UCL Institute for Liver and Digestive Health, Royal Free Hospital, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Cheung, Angela" sort="Cheung, Angela" uniqKey="Cheung A" first="Angela" last="Cheung">Angela Cheung</name>
<affiliation wicri:level="2">
<nlm:affiliation>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Trauner, Michael" sort="Trauner, Michael" uniqKey="Trauner M" first="Michael" last="Trauner">Michael Trauner</name>
<affiliation wicri:level="1">
<nlm:affiliation>Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schramm, Christoph" sort="Schramm, Christoph" uniqKey="Schramm C" first="Christoph" last="Schramm">Christoph Schramm</name>
<affiliation wicri:level="1">
<nlm:affiliation>1st Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany; Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg Eppendorf, Hamburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>1st Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany; Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg Eppendorf, Hamburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chapman, Roger W" sort="Chapman, Roger W" uniqKey="Chapman R" first="Roger W" last="Chapman">Roger W. Chapman</name>
<affiliation wicri:level="1">
<nlm:affiliation>Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom; Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom; Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Karlsen, Tom H" sort="Karlsen, Tom H" uniqKey="Karlsen T" first="Tom H" last="Karlsen">Tom H. Karlsen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schrumpf, Erik" sort="Schrumpf, Erik" uniqKey="Schrumpf E" first="Erik" last="Schrumpf">Erik Schrumpf</name>
<affiliation wicri:level="1">
<nlm:affiliation>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Strassburg, Christian P" sort="Strassburg, Christian P" uniqKey="Strassburg C" first="Christian P" last="Strassburg">Christian P. Strassburg</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine I, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine I, University of Bonn</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Manns, Michael P" sort="Manns, Michael P" uniqKey="Manns M" first="Michael P" last="Manns">Michael P. Manns</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lindor, Keith D" sort="Lindor, Keith D" uniqKey="Lindor K" first="Keith D" last="Lindor">Keith D. Lindor</name>
<affiliation wicri:level="2">
<nlm:affiliation>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Division of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, Arizona; Arizona State University, College of Health Solutions, Phoenix, Arizona.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Division of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, Arizona; Arizona State University, College of Health Solutions, Phoenix</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Hirschfield, Gideon M" sort="Hirschfield, Gideon M" uniqKey="Hirschfield G" first="Gideon M" last="Hirschfield">Gideon M. Hirschfield</name>
<affiliation wicri:level="1">
<nlm:affiliation>National Institute for Health Research (NIHR) Birmingham, Liver Biomedical Research Centre (BRC), University of Birmingham, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Institute for Health Research (NIHR) Birmingham, Liver Biomedical Research Centre (BRC), University of Birmingham</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hansen, Bettina E" sort="Hansen, Bettina E" uniqKey="Hansen B" first="Bettina E" last="Hansen">Bettina E. Hansen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; Toronto Centre for Liver Disease, Toronto General Hospital, Toronto, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; Toronto Centre for Liver Disease, Toronto General Hospital, Toronto</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Boberg, Kirsten M" sort="Boberg, Kirsten M" uniqKey="Boberg K" first="Kirsten M" last="Boberg">Kirsten M. Boberg</name>
<affiliation wicri:level="1">
<nlm:affiliation>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: kboberg@ous-hf.no.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo</wicri:regionArea>
</affiliation>
</author>
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<idno type="RBID">pubmed:28274849</idno>
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<title xml:lang="en">Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis.</title>
<author>
<name sortKey="Weismuller, Tobias J" sort="Weismuller, Tobias J" uniqKey="Weismuller T" first="Tobias J" last="Weismüller">Tobias J. Weismüller</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine I, University of Bonn, Germany; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. Electronic address: tobias.weismueller@gmx.de.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine I, University of Bonn, Germany; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Trivedi, Palak J" sort="Trivedi, Palak J" uniqKey="Trivedi P" first="Palak J" last="Trivedi">Palak J. Trivedi</name>
<affiliation wicri:level="1">
<nlm:affiliation>National Institute for Health Research (NIHR) Birmingham, Liver Biomedical Research Centre (BRC), University of Birmingham, United Kingdom; Liver Unit, University Hospitals Birmingham Queen Elizabeth, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Institute for Health Research (NIHR) Birmingham, Liver Biomedical Research Centre (BRC), University of Birmingham, United Kingdom; Liver Unit, University Hospitals Birmingham Queen Elizabeth</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bergquist, Annika" sort="Bergquist, Annika" uniqKey="Bergquist A" first="Annika" last="Bergquist">Annika Bergquist</name>
<affiliation wicri:level="1">
<nlm:affiliation>Center for Digestive Diseases, Division of Hepatology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Center for Digestive Diseases, Division of Hepatology, Karolinska University Hospital and Karolinska Institutet, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Imam, Mohamad" sort="Imam, Mohamad" uniqKey="Imam M" first="Mohamad" last="Imam">Mohamad Imam</name>
<affiliation wicri:level="2">
<nlm:affiliation>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Department of Internal Medicine, University of North Dakota, Grand Forks, North Dakota.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Dakota du Nord</region>
</placeName>
<wicri:cityArea>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Department of Internal Medicine, University of North Dakota, Grand Forks</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Lenzen, Henrike" sort="Lenzen, Henrike" uniqKey="Lenzen H" first="Henrike" last="Lenzen">Henrike Lenzen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ponsioen, Cyriel Y" sort="Ponsioen, Cyriel Y" uniqKey="Ponsioen C" first="Cyriel Y" last="Ponsioen">Cyriel Y. Ponsioen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Holm, Kristian" sort="Holm, Kristian" uniqKey="Holm K" first="Kristian" last="Holm">Kristian Holm</name>
<affiliation wicri:level="1">
<nlm:affiliation>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Gotthardt, Daniel" sort="Gotthardt, Daniel" uniqKey="Gotthardt D" first="Daniel" last="Gotthardt">Daniel Gotthardt</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology, Infectious Diseases and Intoxications, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gastroenterology, Infectious Diseases and Intoxications, University Hospital Heidelberg, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="F Rkkil, Martti A" sort="F Rkkil, Martti A" uniqKey="F Rkkil M" first="Martti A" last="F Rkkil">Martti A. F Rkkil</name>
<affiliation wicri:level="1">
<nlm:affiliation>Helsinki University, Clinic of Gastroenterology, Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Helsinki University, Clinic of Gastroenterology, Helsinki University Hospital, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Marschall, Hanns Ulrich" sort="Marschall, Hanns Ulrich" uniqKey="Marschall H" first="Hanns-Ulrich" last="Marschall">Hanns-Ulrich Marschall</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Thorburn, Douglas" sort="Thorburn, Douglas" uniqKey="Thorburn D" first="Douglas" last="Thorburn">Douglas Thorburn</name>
<affiliation wicri:level="1">
<nlm:affiliation>The Sheila Sherlock Liver Centre and UCL Institute for Liver and Digestive Health, Royal Free Hospital, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sheila Sherlock Liver Centre and UCL Institute for Liver and Digestive Health, Royal Free Hospital, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Weersma, Rinse K" sort="Weersma, Rinse K" uniqKey="Weersma R" first="Rinse K" last="Weersma">Rinse K. Weersma</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center, Groningen, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center, Groningen</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fevery, Johan" sort="Fevery, Johan" uniqKey="Fevery J" first="Johan" last="Fevery">Johan Fevery</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Hepatology, University Hospital Gasthuisberg, Leuven</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mueller, Tobias" sort="Mueller, Tobias" uniqKey="Mueller T" first="Tobias" last="Mueller">Tobias Mueller</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine, Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chazouilleres, Olivier" sort="Chazouilleres, Olivier" uniqKey="Chazouilleres O" first="Olivier" last="Chazouillères">Olivier Chazouillères</name>
<affiliation wicri:level="1">
<nlm:affiliation>Service d'Hépatologie, Hôpital Saint Antoine, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine Pierre et Marie Curie, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service d'Hépatologie, Hôpital Saint Antoine, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine Pierre et Marie Curie, Paris</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schulze, Kornelius" sort="Schulze, Kornelius" uniqKey="Schulze K" first="Kornelius" last="Schulze">Kornelius Schulze</name>
<affiliation wicri:level="1">
<nlm:affiliation>1st Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>1st Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lazaridis, Konstantinos N" sort="Lazaridis, Konstantinos N" uniqKey="Lazaridis K" first="Konstantinos N" last="Lazaridis">Konstantinos N. Lazaridis</name>
<affiliation wicri:level="2">
<nlm:affiliation>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Almer, Sven" sort="Almer, Sven" uniqKey="Almer S" first="Sven" last="Almer">Sven Almer</name>
<affiliation>
<nlm:affiliation>Division of Gastroenterology and Hepatology, Linköping University, Linköping; Sweden.</nlm:affiliation>
<wicri:noCountry code="subField">Linköping; Sweden</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Pereira, Stephen P" sort="Pereira, Stephen P" uniqKey="Pereira S" first="Stephen P" last="Pereira">Stephen P. Pereira</name>
<affiliation wicri:level="1">
<nlm:affiliation>Institute for Liver and Digestive Health, University College London, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute for Liver and Digestive Health, University College London, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Levy, Cynthia" sort="Levy, Cynthia" uniqKey="Levy C" first="Cynthia" last="Levy">Cynthia Levy</name>
<affiliation wicri:level="2">
<nlm:affiliation>Division of Hepatology, University of Miami, Miami, Florida.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Floride</region>
</placeName>
<wicri:cityArea>Division of Hepatology, University of Miami, Miami</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Mason, Andrew" sort="Mason, Andrew" uniqKey="Mason A" first="Andrew" last="Mason">Andrew Mason</name>
<affiliation wicri:level="1">
<nlm:affiliation>Division of Gastroenterology and Hepatology, University of Alberta, Edmonton, AB, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Gastroenterology and Hepatology, University of Alberta, Edmonton, AB</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Naess, Sigrid" sort="Naess, Sigrid" uniqKey="Naess S" first="Sigrid" last="Naess">Sigrid Naess</name>
<affiliation wicri:level="1">
<nlm:affiliation>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bowlus, Christopher L" sort="Bowlus, Christopher L" uniqKey="Bowlus C" first="Christopher L" last="Bowlus">Christopher L. Bowlus</name>
<affiliation wicri:level="2">
<nlm:affiliation>Division of Gastroenterology and Hepatology, University of California Davis, Davis, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName>
<region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Gastroenterology and Hepatology, University of California Davis, Davis</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Floreani, Annarosa" sort="Floreani, Annarosa" uniqKey="Floreani A" first="Annarosa" last="Floreani">Annarosa Floreani</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Halilbasic, Emina" sort="Halilbasic, Emina" uniqKey="Halilbasic E" first="Emina" last="Halilbasic">Emina Halilbasic</name>
<affiliation wicri:level="1">
<nlm:affiliation>Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Yimam, Kidist K" sort="Yimam, Kidist K" uniqKey="Yimam K" first="Kidist K" last="Yimam">Kidist K. Yimam</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Hepatology and Liver Transplantation, California Pacific Medical Center, San Francisco, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName>
<region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Hepatology and Liver Transplantation, California Pacific Medical Center, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Milkiewicz, Piotr" sort="Milkiewicz, Piotr" uniqKey="Milkiewicz P" first="Piotr" last="Milkiewicz">Piotr Milkiewicz</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin, Poland; Liver and Internal Medicine Unit, Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin, Poland; Liver and Internal Medicine Unit, Department of General, Transplant and Liver Surgery, Medical University of Warsaw</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Beuers, Ulrich" sort="Beuers, Ulrich" uniqKey="Beuers U" first="Ulrich" last="Beuers">Ulrich Beuers</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Huynh, Dep K" sort="Huynh, Dep K" uniqKey="Huynh D" first="Dep K" last="Huynh">Dep K. Huynh</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, SA, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, SA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Pares, Albert" sort="Pares, Albert" uniqKey="Pares A" first="Albert" last="Pares">Albert Pares</name>
<affiliation wicri:level="1">
<nlm:affiliation>Liver Unit, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Liver Unit, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Manser, Christine N" sort="Manser, Christine N" uniqKey="Manser C" first="Christine N" last="Manser">Christine N. Manser</name>
<affiliation wicri:level="1">
<nlm:affiliation>Division for Gastroenterology and Hepatology, University Hospital Zurich (USZ), Zurich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Division for Gastroenterology and Hepatology, University Hospital Zurich (USZ), Zurich</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Dalekos, George N" sort="Dalekos, George N" uniqKey="Dalekos G" first="George N" last="Dalekos">George N. Dalekos</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medicine and Research Laboratory of Internal Medicine, School of Medicine, University of Thessaly, Larissa, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Medicine and Research Laboratory of Internal Medicine, School of Medicine, University of Thessaly, Larissa</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Eksteen, Bertus" sort="Eksteen, Bertus" uniqKey="Eksteen B" first="Bertus" last="Eksteen">Bertus Eksteen</name>
<affiliation wicri:level="1">
<nlm:affiliation>University of Calgary, Snyder Institute for Chronic Diseases, Alberta, AB, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of Calgary, Snyder Institute for Chronic Diseases, Alberta, AB</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Invernizzi, Pietro" sort="Invernizzi, Pietro" uniqKey="Invernizzi P" first="Pietro" last="Invernizzi">Pietro Invernizzi</name>
<affiliation wicri:level="1">
<nlm:affiliation>Program for Autoimmune Liver Diseases, International Center for Digestive Health, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Program for Autoimmune Liver Diseases, International Center for Digestive Health, Department of Medicine and Surgery, University of Milan-Bicocca, Milan</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Berg, Christoph P" sort="Berg, Christoph P" uniqKey="Berg C" first="Christoph P" last="Berg">Christoph P. Berg</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology, Hepatology, and Infectiology, Medical Clinic, University of Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gastroenterology, Hepatology, and Infectiology, Medical Clinic, University of Tübingen</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kirchner, Gabi I" sort="Kirchner, Gabi I" uniqKey="Kirchner G" first="Gabi I" last="Kirchner">Gabi I. Kirchner</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine 1, University Hospital of Regensburg, Regensburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine 1, University Hospital of Regensburg, Regensburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sarrazin, Christoph" sort="Sarrazin, Christoph" uniqKey="Sarrazin C" first="Christoph" last="Sarrazin">Christoph Sarrazin</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine 1, Johann Wolfgang Goethe-University Hospital, Frankfurt, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine 1, Johann Wolfgang Goethe-University Hospital, Frankfurt</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Zimmer, Vincent" sort="Zimmer, Vincent" uniqKey="Zimmer V" first="Vincent" last="Zimmer">Vincent Zimmer</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medicine II, Saarland University Medical Center, Homburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medicine II, Saarland University Medical Center, Homburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fabris, Luca" sort="Fabris, Luca" uniqKey="Fabris L" first="Luca" last="Fabris">Luca Fabris</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Molecular Medicine, University of Padua School of Medicine, Padua, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Molecular Medicine, University of Padua School of Medicine, Padua</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Braun, Felix" sort="Braun, Felix" uniqKey="Braun F" first="Felix" last="Braun">Felix Braun</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of General, Visceral, Thoracic, Transplantation and Pediatric Surgery, Campus Kiel, UKSH, Kiel, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of General, Visceral, Thoracic, Transplantation and Pediatric Surgery, Campus Kiel, UKSH, Kiel</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Marzioni, Marco" sort="Marzioni, Marco" uniqKey="Marzioni M" first="Marco" last="Marzioni">Marco Marzioni</name>
<affiliation wicri:level="1">
<nlm:affiliation>Clinic of Gastroenterology, Università Politecnica delle Marche, Ancona, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Clinic of Gastroenterology, Università Politecnica delle Marche, Ancona</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Juran, Brian D" sort="Juran, Brian D" uniqKey="Juran B" first="Brian D" last="Juran">Brian D. Juran</name>
<affiliation wicri:level="2">
<nlm:affiliation>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Said, Karouk" sort="Said, Karouk" uniqKey="Said K" first="Karouk" last="Said">Karouk Said</name>
<affiliation wicri:level="1">
<nlm:affiliation>Center for Digestive Diseases, Division of Hepatology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Center for Digestive Diseases, Division of Hepatology, Karolinska University Hospital and Karolinska Institutet, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rupp, Christian" sort="Rupp, Christian" uniqKey="Rupp C" first="Christian" last="Rupp">Christian Rupp</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology, Infectious Diseases and Intoxications, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gastroenterology, Infectious Diseases and Intoxications, University Hospital Heidelberg, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jokelainen, Kalle" sort="Jokelainen, Kalle" uniqKey="Jokelainen K" first="Kalle" last="Jokelainen">Kalle Jokelainen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Helsinki University, Clinic of Gastroenterology, Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Helsinki University, Clinic of Gastroenterology, Helsinki University Hospital, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Benito De Valle, Maria" sort="Benito De Valle, Maria" uniqKey="Benito De Valle M" first="Maria" last="Benito De Valle">Maria Benito De Valle</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Saffioti, Francesca" sort="Saffioti, Francesca" uniqKey="Saffioti F" first="Francesca" last="Saffioti">Francesca Saffioti</name>
<affiliation wicri:level="1">
<nlm:affiliation>The Sheila Sherlock Liver Centre and UCL Institute for Liver and Digestive Health, Royal Free Hospital, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sheila Sherlock Liver Centre and UCL Institute for Liver and Digestive Health, Royal Free Hospital, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Cheung, Angela" sort="Cheung, Angela" uniqKey="Cheung A" first="Angela" last="Cheung">Angela Cheung</name>
<affiliation wicri:level="2">
<nlm:affiliation>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Trauner, Michael" sort="Trauner, Michael" uniqKey="Trauner M" first="Michael" last="Trauner">Michael Trauner</name>
<affiliation wicri:level="1">
<nlm:affiliation>Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schramm, Christoph" sort="Schramm, Christoph" uniqKey="Schramm C" first="Christoph" last="Schramm">Christoph Schramm</name>
<affiliation wicri:level="1">
<nlm:affiliation>1st Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany; Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg Eppendorf, Hamburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>1st Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany; Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg Eppendorf, Hamburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chapman, Roger W" sort="Chapman, Roger W" uniqKey="Chapman R" first="Roger W" last="Chapman">Roger W. Chapman</name>
<affiliation wicri:level="1">
<nlm:affiliation>Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom; Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom; Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Karlsen, Tom H" sort="Karlsen, Tom H" uniqKey="Karlsen T" first="Tom H" last="Karlsen">Tom H. Karlsen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schrumpf, Erik" sort="Schrumpf, Erik" uniqKey="Schrumpf E" first="Erik" last="Schrumpf">Erik Schrumpf</name>
<affiliation wicri:level="1">
<nlm:affiliation>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Strassburg, Christian P" sort="Strassburg, Christian P" uniqKey="Strassburg C" first="Christian P" last="Strassburg">Christian P. Strassburg</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine I, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine I, University of Bonn</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Manns, Michael P" sort="Manns, Michael P" uniqKey="Manns M" first="Michael P" last="Manns">Michael P. Manns</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lindor, Keith D" sort="Lindor, Keith D" uniqKey="Lindor K" first="Keith D" last="Lindor">Keith D. Lindor</name>
<affiliation wicri:level="2">
<nlm:affiliation>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Division of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, Arizona; Arizona State University, College of Health Solutions, Phoenix, Arizona.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Division of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, Arizona; Arizona State University, College of Health Solutions, Phoenix</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Hirschfield, Gideon M" sort="Hirschfield, Gideon M" uniqKey="Hirschfield G" first="Gideon M" last="Hirschfield">Gideon M. Hirschfield</name>
<affiliation wicri:level="1">
<nlm:affiliation>National Institute for Health Research (NIHR) Birmingham, Liver Biomedical Research Centre (BRC), University of Birmingham, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Institute for Health Research (NIHR) Birmingham, Liver Biomedical Research Centre (BRC), University of Birmingham</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hansen, Bettina E" sort="Hansen, Bettina E" uniqKey="Hansen B" first="Bettina E" last="Hansen">Bettina E. Hansen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; Toronto Centre for Liver Disease, Toronto General Hospital, Toronto, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; Toronto Centre for Liver Disease, Toronto General Hospital, Toronto</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Boberg, Kirsten M" sort="Boberg, Kirsten M" uniqKey="Boberg K" first="Kirsten M" last="Boberg">Kirsten M. Boberg</name>
<affiliation wicri:level="1">
<nlm:affiliation>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: kboberg@ous-hf.no.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Gastroenterology</title>
<idno type="eISSN">1528-0012</idno>
<imprint>
<date when="2017" type="published">2017</date>
</imprint>
</series>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Adult</term>
<term>Age Distribution</term>
<term>Australia (epidemiology)</term>
<term>Chi-Square Distribution</term>
<term>Cholangitis, Sclerosing (diagnosis)</term>
<term>Cholangitis, Sclerosing (epidemiology)</term>
<term>Cholangitis, Sclerosing (mortality)</term>
<term>Cholangitis, Sclerosing (surgery)</term>
<term>Colitis, Ulcerative (diagnosis)</term>
<term>Colitis, Ulcerative (epidemiology)</term>
<term>Colitis, Ulcerative (mortality)</term>
<term>Colitis, Ulcerative (surgery)</term>
<term>Crohn Disease (diagnosis)</term>
<term>Crohn Disease (epidemiology)</term>
<term>Crohn Disease (mortality)</term>
<term>Crohn Disease (surgery)</term>
<term>Disease Progression</term>
<term>Europe (epidemiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Incidence</term>
<term>Kaplan-Meier Estimate</term>
<term>Liver Transplantation</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>North America (epidemiology)</term>
<term>Phenotype</term>
<term>Prognosis</term>
<term>Proportional Hazards Models</term>
<term>Retrospective Studies</term>
<term>Risk Assessment</term>
<term>Risk Factors</term>
<term>Sex Distribution</term>
<term>Time Factors</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Amérique du Nord (épidémiologie)</term>
<term>Analyse multivariée</term>
<term>Angiocholite sclérosante ()</term>
<term>Angiocholite sclérosante (diagnostic)</term>
<term>Angiocholite sclérosante (mortalité)</term>
<term>Angiocholite sclérosante (épidémiologie)</term>
<term>Australie (épidémiologie)</term>
<term>Estimation de Kaplan-Meier</term>
<term>Europe (épidémiologie)</term>
<term>Facteurs de risque</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Jeune adulte</term>
<term>Loi du khi-deux</term>
<term>Maladie de Crohn ()</term>
<term>Maladie de Crohn (diagnostic)</term>
<term>Maladie de Crohn (mortalité)</term>
<term>Maladie de Crohn (épidémiologie)</term>
<term>Modèles de hasards proportionnels</term>
<term>Mâle</term>
<term>Phénotype</term>
<term>Pronostic</term>
<term>Rectocolite hémorragique ()</term>
<term>Rectocolite hémorragique (diagnostic)</term>
<term>Rectocolite hémorragique (mortalité)</term>
<term>Rectocolite hémorragique (épidémiologie)</term>
<term>Répartition par sexe</term>
<term>Répartition par âge</term>
<term>Transplantation hépatique</term>
<term>Études rétrospectives</term>
<term>Évaluation des risques</term>
<term>Évolution de la maladie</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en">
<term>Cholangitis, Sclerosing</term>
<term>Colitis, Ulcerative</term>
<term>Crohn Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr">
<term>Angiocholite sclérosante</term>
<term>Maladie de Crohn</term>
<term>Rectocolite hémorragique</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Australia</term>
<term>Cholangitis, Sclerosing</term>
<term>Colitis, Ulcerative</term>
<term>Crohn Disease</term>
<term>Europe</term>
<term>North America</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en">
<term>Cholangitis, Sclerosing</term>
<term>Colitis, Ulcerative</term>
<term>Crohn Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr">
<term>Angiocholite sclérosante</term>
<term>Maladie de Crohn</term>
<term>Rectocolite hémorragique</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en">
<term>Cholangitis, Sclerosing</term>
<term>Colitis, Ulcerative</term>
<term>Crohn Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr">
<term>Amérique du Nord</term>
<term>Angiocholite sclérosante</term>
<term>Australie</term>
<term>Europe</term>
<term>Maladie de Crohn</term>
<term>Rectocolite hémorragique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Age Distribution</term>
<term>Chi-Square Distribution</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Incidence</term>
<term>Kaplan-Meier Estimate</term>
<term>Liver Transplantation</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Phenotype</term>
<term>Prognosis</term>
<term>Proportional Hazards Models</term>
<term>Retrospective Studies</term>
<term>Risk Assessment</term>
<term>Risk Factors</term>
<term>Sex Distribution</term>
<term>Time Factors</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse multivariée</term>
<term>Angiocholite sclérosante</term>
<term>Estimation de Kaplan-Meier</term>
<term>Facteurs de risque</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Jeune adulte</term>
<term>Loi du khi-deux</term>
<term>Maladie de Crohn</term>
<term>Modèles de hasards proportionnels</term>
<term>Mâle</term>
<term>Phénotype</term>
<term>Pronostic</term>
<term>Rectocolite hémorragique</term>
<term>Répartition par sexe</term>
<term>Répartition par âge</term>
<term>Transplantation hépatique</term>
<term>Études rétrospectives</term>
<term>Évaluation des risques</term>
<term>Évolution de la maladie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of disease progression based on distinct clinical phenotypes in a large international cohort of patients with PSC.</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="MEDLINE" Owner="NLM">
<PMID Version="1">28274849</PMID>
<DateCreated>
<Year>2017</Year>
<Month>03</Month>
<Day>09</Day>
</DateCreated>
<DateCompleted>
<Year>2017</Year>
<Month>08</Month>
<Day>14</Day>
</DateCompleted>
<DateRevised>
<Year>2017</Year>
<Month>08</Month>
<Day>14</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1528-0012</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>152</Volume>
<Issue>8</Issue>
<PubDate>
<Year>2017</Year>
<Month>Jun</Month>
</PubDate>
</JournalIssue>
<Title>Gastroenterology</Title>
<ISOAbbreviation>Gastroenterology</ISOAbbreviation>
</Journal>
<ArticleTitle>Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis.</ArticleTitle>
<Pagination>
<MedlinePgn>1975-1984.e8</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0016-5085(17)30236-6</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1053/j.gastro.2017.02.038</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND & AIMS" NlmCategory="OBJECTIVE">Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of disease progression based on distinct clinical phenotypes in a large international cohort of patients with PSC.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We performed a retrospective outcome analysis of patients diagnosed with PSC from 1980 through 2010 at 37 centers in Europe, North America, and Australia. For each patient, we collected data on sex, clinician-reported age at and date of PSC and IBD diagnoses, phenotypes of IBD and PSC, and date and indication of IBD-related surgeries. The primary and secondary endpoints were liver transplantation or death (LTD) and hepatopancreatobiliary malignancy, respectively. Cox proportional hazards models were applied to determine the effects of individual covariates on rates of clinical events, with time-to-event analysis ascertained through Kaplan-Meier estimates.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Of the 7121 patients in the cohort, 2616 met the primary endpoint (median time to event of 14.5 years) and 721 developed hepatopancreatobiliary malignancy. The most common malignancy was cholangiocarcinoma (n = 594); patients of advanced age at diagnosis had an increased incidence compared with younger patients (incidence rate: 1.2 per 100 patient-years for patients younger than 20 years old, 6.0 per 100 patient-years for patients 21-30 years old, 9.0 per 100 patient-years for patients 31-40 years old, 14.0 per 100 patient-years for patients 41-50 years old, 15.2 per 100 patient-years for patients 51-60 years old, and 21.0 per 100 patient-years for patients older than 60 years). Of all patients with PSC studied, 65.5% were men, 89.8% had classical or large-duct disease, and 70.0% developed IBD at some point. Assessing the development of IBD as a time-dependent covariate, Crohn's disease and no IBD (both vs ulcerative colitis) were associated with a lower risk of LTD (unadjusted hazard ratio [HR], 0.62; P < .001 and HR, 0.90; P = .03, respectively) and malignancy (HR, 0.68; P = .008 and HR, 0.77; P = .004, respectively). Small-duct PSC was associated with a lower risk of LTD or malignancy compared with classic PSC (HR, 0.30 and HR, 0.15, respectively; both P < .001). Female sex was also associated with a lower risk of LTD or malignancy (HR, 0.88; P = .002 and HR, 0.68; P < .001, respectively). In multivariable analyses assessing the primary endpoint, small-duct PSC characterized a low-risk phenotype in both sexes (adjusted HR for men, 0.23; P < .001 and adjusted HR for women, 0.48; P = .003). Conversely, patients with ulcerative colitis had an increased risk of liver disease progression compared with patients with Crohn's disease (HR, 1.56; P < .001) or no IBD (HR, 1.15; P = .002).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In an analysis of data from individual patients with PSC worldwide, we found significant variation in clinical course associated with age at diagnosis, sex, and ductal and IBD subtypes. The survival estimates provided might be used to estimate risk levels for patients with PSC and select patients for clinical trials.</AbstractText>
<CopyrightInformation>Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Weismüller</LastName>
<ForeName>Tobias J</ForeName>
<Initials>TJ</Initials>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine I, University of Bonn, Germany; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. Electronic address: tobias.weismueller@gmx.de.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Trivedi</LastName>
<ForeName>Palak J</ForeName>
<Initials>PJ</Initials>
<AffiliationInfo>
<Affiliation>National Institute for Health Research (NIHR) Birmingham, Liver Biomedical Research Centre (BRC), University of Birmingham, United Kingdom; Liver Unit, University Hospitals Birmingham Queen Elizabeth, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Bergquist</LastName>
<ForeName>Annika</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Center for Digestive Diseases, Division of Hepatology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Imam</LastName>
<ForeName>Mohamad</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Department of Internal Medicine, University of North Dakota, Grand Forks, North Dakota.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Lenzen</LastName>
<ForeName>Henrike</ForeName>
<Initials>H</Initials>
<AffiliationInfo>
<Affiliation>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Ponsioen</LastName>
<ForeName>Cyriel Y</ForeName>
<Initials>CY</Initials>
<AffiliationInfo>
<Affiliation>Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Holm</LastName>
<ForeName>Kristian</ForeName>
<Initials>K</Initials>
<AffiliationInfo>
<Affiliation>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Gotthardt</LastName>
<ForeName>Daniel</ForeName>
<Initials>D</Initials>
<AffiliationInfo>
<Affiliation>Department of Gastroenterology, Infectious Diseases and Intoxications, University Hospital Heidelberg, Heidelberg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Färkkilä</LastName>
<ForeName>Martti A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo>
<Affiliation>Helsinki University, Clinic of Gastroenterology, Helsinki University Hospital, Helsinki, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Marschall</LastName>
<ForeName>Hanns-Ulrich</ForeName>
<Initials>HU</Initials>
<AffiliationInfo>
<Affiliation>Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Thorburn</LastName>
<ForeName>Douglas</ForeName>
<Initials>D</Initials>
<AffiliationInfo>
<Affiliation>The Sheila Sherlock Liver Centre and UCL Institute for Liver and Digestive Health, Royal Free Hospital, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Weersma</LastName>
<ForeName>Rinse K</ForeName>
<Initials>RK</Initials>
<AffiliationInfo>
<Affiliation>Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center, Groningen, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Fevery</LastName>
<ForeName>Johan</ForeName>
<Initials>J</Initials>
<AffiliationInfo>
<Affiliation>Department of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Mueller</LastName>
<ForeName>Tobias</ForeName>
<Initials>T</Initials>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Chazouillères</LastName>
<ForeName>Olivier</ForeName>
<Initials>O</Initials>
<AffiliationInfo>
<Affiliation>Service d'Hépatologie, Hôpital Saint Antoine, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine Pierre et Marie Curie, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Schulze</LastName>
<ForeName>Kornelius</ForeName>
<Initials>K</Initials>
<AffiliationInfo>
<Affiliation>1st Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Lazaridis</LastName>
<ForeName>Konstantinos N</ForeName>
<Initials>KN</Initials>
<AffiliationInfo>
<Affiliation>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Almer</LastName>
<ForeName>Sven</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>Division of Gastroenterology and Hepatology, Linköping University, Linköping; Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Pereira</LastName>
<ForeName>Stephen P</ForeName>
<Initials>SP</Initials>
<AffiliationInfo>
<Affiliation>Institute for Liver and Digestive Health, University College London, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Levy</LastName>
<ForeName>Cynthia</ForeName>
<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>Division of Hepatology, University of Miami, Miami, Florida.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Mason</LastName>
<ForeName>Andrew</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Division of Gastroenterology and Hepatology, University of Alberta, Edmonton, AB, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Naess</LastName>
<ForeName>Sigrid</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Bowlus</LastName>
<ForeName>Christopher L</ForeName>
<Initials>CL</Initials>
<AffiliationInfo>
<Affiliation>Division of Gastroenterology and Hepatology, University of California Davis, Davis, California.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Floreani</LastName>
<ForeName>Annarosa</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Halilbasic</LastName>
<ForeName>Emina</ForeName>
<Initials>E</Initials>
<AffiliationInfo>
<Affiliation>Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Yimam</LastName>
<ForeName>Kidist K</ForeName>
<Initials>KK</Initials>
<AffiliationInfo>
<Affiliation>Department of Hepatology and Liver Transplantation, California Pacific Medical Center, San Francisco, California.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Milkiewicz</LastName>
<ForeName>Piotr</ForeName>
<Initials>P</Initials>
<AffiliationInfo>
<Affiliation>Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin, Poland; Liver and Internal Medicine Unit, Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Poland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Beuers</LastName>
<ForeName>Ulrich</ForeName>
<Initials>U</Initials>
<AffiliationInfo>
<Affiliation>Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Huynh</LastName>
<ForeName>Dep K</ForeName>
<Initials>DK</Initials>
<AffiliationInfo>
<Affiliation>Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, SA, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Pares</LastName>
<ForeName>Albert</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Liver Unit, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Manser</LastName>
<ForeName>Christine N</ForeName>
<Initials>CN</Initials>
<AffiliationInfo>
<Affiliation>Division for Gastroenterology and Hepatology, University Hospital Zurich (USZ), Zurich, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Dalekos</LastName>
<ForeName>George N</ForeName>
<Initials>GN</Initials>
<AffiliationInfo>
<Affiliation>Department of Medicine and Research Laboratory of Internal Medicine, School of Medicine, University of Thessaly, Larissa, Greece.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Eksteen</LastName>
<ForeName>Bertus</ForeName>
<Initials>B</Initials>
<AffiliationInfo>
<Affiliation>University of Calgary, Snyder Institute for Chronic Diseases, Alberta, AB, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Invernizzi</LastName>
<ForeName>Pietro</ForeName>
<Initials>P</Initials>
<AffiliationInfo>
<Affiliation>Program for Autoimmune Liver Diseases, International Center for Digestive Health, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Berg</LastName>
<ForeName>Christoph P</ForeName>
<Initials>CP</Initials>
<AffiliationInfo>
<Affiliation>Department of Gastroenterology, Hepatology, and Infectiology, Medical Clinic, University of Tübingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Kirchner</LastName>
<ForeName>Gabi I</ForeName>
<Initials>GI</Initials>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine 1, University Hospital of Regensburg, Regensburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Sarrazin</LastName>
<ForeName>Christoph</ForeName>
<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine 1, Johann Wolfgang Goethe-University Hospital, Frankfurt, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Zimmer</LastName>
<ForeName>Vincent</ForeName>
<Initials>V</Initials>
<AffiliationInfo>
<Affiliation>Department of Medicine II, Saarland University Medical Center, Homburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Fabris</LastName>
<ForeName>Luca</ForeName>
<Initials>L</Initials>
<AffiliationInfo>
<Affiliation>Department of Molecular Medicine, University of Padua School of Medicine, Padua, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Braun</LastName>
<ForeName>Felix</ForeName>
<Initials>F</Initials>
<AffiliationInfo>
<Affiliation>Department of General, Visceral, Thoracic, Transplantation and Pediatric Surgery, Campus Kiel, UKSH, Kiel, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Marzioni</LastName>
<ForeName>Marco</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Clinic of Gastroenterology, Università Politecnica delle Marche, Ancona, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Juran</LastName>
<ForeName>Brian D</ForeName>
<Initials>BD</Initials>
<AffiliationInfo>
<Affiliation>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Said</LastName>
<ForeName>Karouk</ForeName>
<Initials>K</Initials>
<AffiliationInfo>
<Affiliation>Center for Digestive Diseases, Division of Hepatology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Rupp</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>Department of Gastroenterology, Infectious Diseases and Intoxications, University Hospital Heidelberg, Heidelberg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Jokelainen</LastName>
<ForeName>Kalle</ForeName>
<Initials>K</Initials>
<AffiliationInfo>
<Affiliation>Helsinki University, Clinic of Gastroenterology, Helsinki University Hospital, Helsinki, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Benito de Valle</LastName>
<ForeName>Maria</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Saffioti</LastName>
<ForeName>Francesca</ForeName>
<Initials>F</Initials>
<AffiliationInfo>
<Affiliation>The Sheila Sherlock Liver Centre and UCL Institute for Liver and Digestive Health, Royal Free Hospital, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Cheung</LastName>
<ForeName>Angela</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Trauner</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Schramm</LastName>
<ForeName>Christoph</ForeName>
<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>1st Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany; Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg Eppendorf, Hamburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Chapman</LastName>
<ForeName>Roger W</ForeName>
<Initials>RW</Initials>
<AffiliationInfo>
<Affiliation>Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom; Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Karlsen</LastName>
<ForeName>Tom H</ForeName>
<Initials>TH</Initials>
<AffiliationInfo>
<Affiliation>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Schrumpf</LastName>
<ForeName>Erik</ForeName>
<Initials>E</Initials>
<AffiliationInfo>
<Affiliation>Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Strassburg</LastName>
<ForeName>Christian P</ForeName>
<Initials>CP</Initials>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine I, University of Bonn, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Manns</LastName>
<ForeName>Michael P</ForeName>
<Initials>MP</Initials>
<AffiliationInfo>
<Affiliation>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Lindor</LastName>
<ForeName>Keith D</ForeName>
<Initials>KD</Initials>
<AffiliationInfo>
<Affiliation>Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Division of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, Arizona; Arizona State University, College of Health Solutions, Phoenix, Arizona.</Affiliation>
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