Circulating concentrations of biomarkers and metabolites related to vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations.
Identifieur interne : 000A52 ( PubMed/Curation ); précédent : 000A51; suivant : 000A53Circulating concentrations of biomarkers and metabolites related to vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations.
Auteurs : Ivind Midttun [Norvège] ; Despoina Theofylaktopoulou [Norvège] ; Adrian Mccann [Norvège] ; Anouar Fanidi [France] ; David C. Muller [France] ; Klaus Meyer [Norvège] ; Arve Ulvik [Norvège] ; Wei Zheng [États-Unis] ; Xiao-Ou Shu [États-Unis] ; Yong-Bing Xiang [République populaire de Chine] ; Ross Prentice [États-Unis] ; Cynthia A. Thomson [États-Unis] ; Mary Pettinger [États-Unis] ; Graham G. Giles [Australie] ; Allison Hodge [Australie] ; Qiuyin Cai [États-Unis] ; William J. Blot [États-Unis] ; Jie Wu [États-Unis] ; Mikael Johansson ; Johan Hultdin [Suède] ; Kjell Grankvist [Suède] ; Victoria L. Stevens [États-Unis] ; Marjorie L. Mccullough [États-Unis] ; Stephanie J. Weinstein [États-Unis] ; Demetrius Albanes [États-Unis] ; Arnulf Langhammer [Norvège] ; Kristian Hveem [Norvège] ; Marit N Ss [Norvège] ; Howard D. Sesso ; J Michael Gaziano [États-Unis] ; Julie E. Buring ; I-Min Lee ; Gianluca Severi [Italie] ; Xuehong Zhang [États-Unis] ; Jiali Han ; Meir J. Stampfer ; Stephanie A. Smith-Warner ; Anne Zeleniuch-Jacquotte [États-Unis] ; Loic Le Marchand [États-Unis] ; Jian-Min Yuan [États-Unis] ; Lesley M. Butler [États-Unis] ; Woon-Puay Koh [Singapour] ; Renwei Wang [États-Unis] ; Yu-Tang Gao [République populaire de Chine] ; Ulrika Ericson [Suède] ; Emily Sonestedt [Suède] ; Regina G. Ziegler [États-Unis] ; Neal D. Freedman [États-Unis] ; Kala Visvanathan [États-Unis] ; Miranda R. Jones [États-Unis] ; Caroline Relton [Royaume-Uni] ; Paul Brennan [France] ; Mattias Johansson [France] ; Per M. Ueland [Norvège]Source :
- The American journal of clinical nutrition [ 1938-3207 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Asie, Australie, Carbone (sang), Complexe vitaminique B (sang), Compléments alimentaires, Cynurénine (sang), Femelle, Humains, Laboratoires, Marqueurs biologiques (sang), Mâle, Pays nordiques et scandinaves, Rétinol (sang), Sujet âgé, Tryptophane (sang), Vitamine D (sang), alpha-Tocophérol (sang), États-Unis d'Amérique, Études transversales.
- MESH :
- sang : Carbone, Complexe vitaminique B, Cynurénine, Marqueurs biologiques, Rétinol, Tryptophane, Vitamine D, alpha-Tocophérol.
- Adulte d'âge moyen, Asie, Australie, Compléments alimentaires, Femelle, Humains, Laboratoires, Mâle, Pays nordiques et scandinaves, Sujet âgé, États-Unis d'Amérique, Études transversales.
English descriptors
- KwdEn :
- Aged, Asia, Australia, Biomarkers (blood), Carbon (blood), Cross-Sectional Studies, Dietary Supplements, Female, Humans, Kynurenine (blood), Laboratories, Male, Middle Aged, Scandinavian and Nordic Countries, Tryptophan (blood), United States, Vitamin A (blood), Vitamin B Complex (blood), Vitamin D (blood), alpha-Tocopherol (blood).
- MESH :
- chemical , blood : Biomarkers, Carbon, Kynurenine, Tryptophan, Vitamin A, Vitamin B Complex, Vitamin D, alpha-Tocopherol.
- Aged, Asia, Australia, Cross-Sectional Studies, Dietary Supplements, Female, Humans, Laboratories, Male, Middle Aged, Scandinavian and Nordic Countries, United States.
Abstract
Background: Circulating concentrations of biomarkers that are related to vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies.Objective: We robustly and comprehensively assessed differences in biomarkers that are related to vitamin status across geographic regions.Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory.Results: Circulating concentrations of riboflavin, pyridoxal 5'-phosphate, folate, vitamin B-12, all-trans retinol, 25-hydroxyvitamin D, and α-tocopherol as well as combined vitamin scores that were based on these nutrients showed that the general B-vitamin concentration was highest in the United States and that the B vitamins and lipid soluble vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-vitamin concentration in the United States appears to be driven mainly by multivitamin-supplement users.Conclusions: The observed differences likely reflect the variation in intake of vitamins and, in particular, the widespread multivitamin-supplement use in the United States. The results provide valuable information about the differences in biomarker concentrations in populations across continents.
DOI: 10.3945/ajcn.116.151241
PubMed: 28424186
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Mikael Johansson<affiliation><nlm:affiliation>Department of Radiation Sciences, Oncology, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Divisions of Preventive Medicine and.</nlm:affiliation><wicri:noCountry code="no comma">Divisions of Preventive Medicine and.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Divisions of Preventive Medicine and.</nlm:affiliation><wicri:noCountry code="no comma">Divisions of Preventive Medicine and.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Divisions of Preventive Medicine and.</nlm:affiliation><wicri:noCountry code="no comma">Divisions of Preventive Medicine and.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Departments of Epidemiology and.</nlm:affiliation><wicri:noCountry code="no comma">Departments of Epidemiology and.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Departments of Epidemiology and.</nlm:affiliation><wicri:noCountry code="no comma">Departments of Epidemiology and.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Departments of Epidemiology and.</nlm:affiliation><wicri:noCountry code="no comma">Departments of Epidemiology and.</wicri:noCountry></affiliation>Le document en format XML
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Thomson</name><affiliation wicri:level="2"><nlm:affiliation>Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson</wicri:cityArea></affiliation></author><author><name sortKey="Pettinger, Mary" sort="Pettinger, Mary" uniqKey="Pettinger M" first="Mary" last="Pettinger">Mary Pettinger</name><affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Center, Cancer Council Victoria, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Center, Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Hodge, Allison" sort="Hodge, Allison" uniqKey="Hodge A" first="Allison" last="Hodge">Allison Hodge</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Center, Cancer Council Victoria, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Center, Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation wicri:level="2"><nlm:affiliation>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Blot, William J" sort="Blot, William J" uniqKey="Blot W" first="William J" last="Blot">William J. Blot</name><affiliation wicri:level="2"><nlm:affiliation>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Wu, Jie" sort="Wu, Jie" uniqKey="Wu J" first="Jie" last="Wu">Jie Wu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Johansson, Mikael" sort="Johansson, Mikael" uniqKey="Johansson M" first="Mikael" last="Johansson">Mikael Johansson</name><affiliation><nlm:affiliation>Department of Radiation Sciences, Oncology, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Hultdin, Johan" sort="Hultdin, Johan" uniqKey="Hultdin J" first="Johan" last="Hultdin">Johan Hultdin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Grankvist, Kjell" sort="Grankvist, Kjell" uniqKey="Grankvist K" first="Kjell" last="Grankvist">Kjell Grankvist</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L" last="Stevens">Victoria L. Stevens</name><affiliation wicri:level="2"><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, GA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Epidemiology Research Program, American Cancer Society, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Mccullough, Marjorie L" sort="Mccullough, Marjorie L" uniqKey="Mccullough M" first="Marjorie L" last="Mccullough">Marjorie L. Mccullough</name><affiliation wicri:level="2"><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, GA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Epidemiology Research Program, American Cancer Society, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Weinstein, Stephanie J" sort="Weinstein, Stephanie J" uniqKey="Weinstein S" first="Stephanie J" last="Weinstein">Stephanie J. Weinstein</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Langhammer, Arnulf" sort="Langhammer, Arnulf" uniqKey="Langhammer A" first="Arnulf" last="Langhammer">Arnulf Langhammer</name><affiliation wicri:level="1"><nlm:affiliation>Nord-Trøndelag Health Study Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Levanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Nord-Trøndelag Health Study Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Levanger</wicri:regionArea></affiliation></author><author><name sortKey="Hveem, Kristian" sort="Hveem, Kristian" uniqKey="Hveem K" first="Kristian" last="Hveem">Kristian Hveem</name><affiliation wicri:level="1"><nlm:affiliation>Nord-Trøndelag Health Study Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Levanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Nord-Trøndelag Health Study Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Levanger</wicri:regionArea></affiliation></author><author><name sortKey="N Ss, Marit" sort="N Ss, Marit" uniqKey="N Ss M" first="Marit" last="N Ss">Marit N Ss</name><affiliation wicri:level="1"><nlm:affiliation>Nord-Trøndelag Health Study Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Levanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Nord-Trøndelag Health Study Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Levanger</wicri:regionArea></affiliation></author><author><name sortKey="Sesso, Howard D" sort="Sesso, Howard D" uniqKey="Sesso H" first="Howard D" last="Sesso">Howard D. Sesso</name><affiliation><nlm:affiliation>Divisions of Preventive Medicine and.</nlm:affiliation><wicri:noCountry code="no comma">Divisions of Preventive Medicine and.</wicri:noCountry></affiliation></author><author><name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J Michael" last="Gaziano">J Michael Gaziano</name><affiliation wicri:level="2"><nlm:affiliation>Aging, Brigham and Women's Hospital, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Aging, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Buring, Julie E" sort="Buring, Julie E" uniqKey="Buring J" first="Julie E" last="Buring">Julie E. Buring</name><affiliation><nlm:affiliation>Divisions of Preventive Medicine and.</nlm:affiliation><wicri:noCountry code="no comma">Divisions of Preventive Medicine and.</wicri:noCountry></affiliation></author><author><name sortKey="Lee, I Min" sort="Lee, I Min" uniqKey="Lee I" first="I-Min" last="Lee">I-Min Lee</name><affiliation><nlm:affiliation>Divisions of Preventive Medicine and.</nlm:affiliation><wicri:noCountry code="no comma">Divisions of Preventive Medicine and.</wicri:noCountry></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation wicri:level="1"><nlm:affiliation>Human Genetics Foundation, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Human Genetics Foundation, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Xuehong" sort="Zhang, Xuehong" uniqKey="Zhang X" first="Xuehong" last="Zhang">Xuehong Zhang</name><affiliation wicri:level="2"><nlm:affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Han, Jiali" sort="Han, Jiali" uniqKey="Han J" first="Jiali" last="Han">Jiali Han</name><affiliation><nlm:affiliation>Departments of Epidemiology and.</nlm:affiliation><wicri:noCountry code="no comma">Departments of Epidemiology and.</wicri:noCountry></affiliation></author><author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J" last="Stampfer">Meir J. Stampfer</name><affiliation><nlm:affiliation>Departments of Epidemiology and.</nlm:affiliation><wicri:noCountry code="no comma">Departments of Epidemiology and.</wicri:noCountry></affiliation></author><author><name sortKey="Smith Warner, Stephanie A" sort="Smith Warner, Stephanie A" uniqKey="Smith Warner S" first="Stephanie A" last="Smith-Warner">Stephanie A. Smith-Warner</name><affiliation><nlm:affiliation>Departments of Epidemiology and.</nlm:affiliation><wicri:noCountry code="no comma">Departments of Epidemiology and.</wicri:noCountry></affiliation></author><author><name sortKey="Zeleniuch Jacquotte, Anne" sort="Zeleniuch Jacquotte, Anne" uniqKey="Zeleniuch Jacquotte A" first="Anne" last="Zeleniuch-Jacquotte">Anne Zeleniuch-Jacquotte</name><affiliation wicri:level="2"><nlm:affiliation>Department of Population Health, New York University School of Medicine, New York, NY.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Population Health, New York University School of Medicine, New York</wicri:cityArea></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="2"><nlm:affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Epidemiology Program, University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Butler, Lesley M" sort="Butler, Lesley M" uniqKey="Butler L" first="Lesley M" last="Butler">Lesley M. Butler</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Koh, Woon Puay" sort="Koh, Woon Puay" uniqKey="Koh W" first="Woon-Puay" last="Koh">Woon-Puay Koh</name><affiliation wicri:level="1"><nlm:affiliation>Duke-National University of Singapore (NSU) Medical School, Singapore, and Saw Swee Hock School of Public Health, NSU, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-National University of Singapore (NSU) Medical School, Singapore, and Saw Swee Hock School of Public Health, NSU, Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Renwei" sort="Wang, Renwei" uniqKey="Wang R" first="Renwei" last="Wang">Renwei Wang</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Ericson, Ulrika" sort="Ericson, Ulrika" uniqKey="Ericson U" first="Ulrika" last="Ericson">Ulrika Ericson</name><affiliation wicri:level="1"><nlm:affiliation>Department of clinical sciences Malmö, Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of clinical sciences Malmö, Lund University, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Sonestedt, Emily" sort="Sonestedt, Emily" uniqKey="Sonestedt E" first="Emily" last="Sonestedt">Emily Sonestedt</name><affiliation wicri:level="1"><nlm:affiliation>Department of clinical sciences Malmö, Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of clinical sciences Malmö, Lund University, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G" last="Ziegler">Regina G. Ziegler</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Freedman, Neal D" sort="Freedman, Neal D" uniqKey="Freedman N" first="Neal D" last="Freedman">Neal D. Freedman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Visvanathan, Kala" sort="Visvanathan, Kala" uniqKey="Visvanathan K" first="Kala" last="Visvanathan">Kala Visvanathan</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Sidney Kimmel Comprehensive Center, School of Medicine, Baltimore, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Sidney Kimmel Comprehensive Center, School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Jones, Miranda R" sort="Jones, Miranda R" uniqKey="Jones M" first="Miranda R" last="Jones">Miranda R. Jones</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Sidney Kimmel Comprehensive Center, School of Medicine, Baltimore, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Sidney Kimmel Comprehensive Center, School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Relton, Caroline" sort="Relton, Caroline" uniqKey="Relton C" first="Caroline" last="Relton">Caroline Relton</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Genetic Medicine, Newcastle University, Newcastle</wicri:regionArea></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Ueland, Per M" sort="Ueland, Per M" uniqKey="Ueland P" first="Per M" last="Ueland">Per M. Ueland</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Science, University of Bergen, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Clinical Science, University of Bergen, Bergen</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28424186</idno><idno type="pmid">28424186</idno><idno type="doi">10.3945/ajcn.116.151241</idno><idno type="wicri:Area/PubMed/Corpus">000A55</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A55</idno><idno type="wicri:Area/PubMed/Curation">000A52</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A52</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Circulating concentrations of biomarkers and metabolites related to vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations.</title><author><name sortKey="Midttun, Ivind" sort="Midttun, Ivind" uniqKey="Midttun " first=" Ivind" last="Midttun"> Ivind Midttun</name><affiliation wicri:level="1"><nlm:affiliation>Bevital AS, Bergen, Norway; nkjbm@uib.no.</nlm:affiliation><country wicri:rule="url">Norvège</country><wicri:regionArea>Bevital AS, Bergen</wicri:regionArea></affiliation></author><author><name sortKey="Theofylaktopoulou, Despoina" sort="Theofylaktopoulou, Despoina" uniqKey="Theofylaktopoulou D" first="Despoina" last="Theofylaktopoulou">Despoina Theofylaktopoulou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Science, University of Bergen, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Clinical Science, University of Bergen, Bergen</wicri:regionArea></affiliation></author><author><name sortKey="Mccann, Adrian" sort="Mccann, Adrian" uniqKey="Mccann A" first="Adrian" last="Mccann">Adrian Mccann</name><affiliation wicri:level="1"><nlm:affiliation>Bevital AS, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Bevital AS, Bergen</wicri:regionArea></affiliation></author><author><name sortKey="Fanidi, Anouar" sort="Fanidi, Anouar" uniqKey="Fanidi A" first="Anouar" last="Fanidi">Anouar Fanidi</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Muller, David C" sort="Muller, David C" uniqKey="Muller D" first="David C" last="Muller">David C. Muller</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Meyer, Klaus" sort="Meyer, Klaus" uniqKey="Meyer K" first="Klaus" last="Meyer">Klaus Meyer</name><affiliation wicri:level="1"><nlm:affiliation>Bevital AS, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Bevital AS, Bergen</wicri:regionArea></affiliation></author><author><name sortKey="Ulvik, Arve" sort="Ulvik, Arve" uniqKey="Ulvik A" first="Arve" last="Ulvik">Arve Ulvik</name><affiliation wicri:level="1"><nlm:affiliation>Bevital AS, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Bevital AS, Bergen</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="2"><nlm:affiliation>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Xiang, Yong Bing" sort="Xiang, Yong Bing" uniqKey="Xiang Y" first="Yong-Bing" last="Xiang">Yong-Bing Xiang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Prentice, Ross" sort="Prentice, Ross" uniqKey="Prentice R" first="Ross" last="Prentice">Ross Prentice</name><affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Thomson, Cynthia A" sort="Thomson, Cynthia A" uniqKey="Thomson C" first="Cynthia A" last="Thomson">Cynthia A. Thomson</name><affiliation wicri:level="2"><nlm:affiliation>Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson</wicri:cityArea></affiliation></author><author><name sortKey="Pettinger, Mary" sort="Pettinger, Mary" uniqKey="Pettinger M" first="Mary" last="Pettinger">Mary Pettinger</name><affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Center, Cancer Council Victoria, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Center, Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Hodge, Allison" sort="Hodge, Allison" uniqKey="Hodge A" first="Allison" last="Hodge">Allison Hodge</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Center, Cancer Council Victoria, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Center, Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation wicri:level="2"><nlm:affiliation>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Blot, William J" sort="Blot, William J" uniqKey="Blot W" first="William J" last="Blot">William J. Blot</name><affiliation wicri:level="2"><nlm:affiliation>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Wu, Jie" sort="Wu, Jie" uniqKey="Wu J" first="Jie" last="Wu">Jie Wu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Johansson, Mikael" sort="Johansson, Mikael" uniqKey="Johansson M" first="Mikael" last="Johansson">Mikael Johansson</name><affiliation><nlm:affiliation>Department of Radiation Sciences, Oncology, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Hultdin, Johan" sort="Hultdin, Johan" uniqKey="Hultdin J" first="Johan" last="Hultdin">Johan Hultdin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Grankvist, Kjell" sort="Grankvist, Kjell" uniqKey="Grankvist K" first="Kjell" last="Grankvist">Kjell Grankvist</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L" last="Stevens">Victoria L. Stevens</name><affiliation wicri:level="2"><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, GA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Epidemiology Research Program, American Cancer Society, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Mccullough, Marjorie L" sort="Mccullough, Marjorie L" uniqKey="Mccullough M" first="Marjorie L" last="Mccullough">Marjorie L. Mccullough</name><affiliation wicri:level="2"><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, GA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Epidemiology Research Program, American Cancer Society, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Weinstein, Stephanie J" sort="Weinstein, Stephanie J" uniqKey="Weinstein S" first="Stephanie J" last="Weinstein">Stephanie J. Weinstein</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Langhammer, Arnulf" sort="Langhammer, Arnulf" uniqKey="Langhammer A" first="Arnulf" last="Langhammer">Arnulf Langhammer</name><affiliation wicri:level="1"><nlm:affiliation>Nord-Trøndelag Health Study Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Levanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Nord-Trøndelag Health Study Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Levanger</wicri:regionArea></affiliation></author><author><name sortKey="Hveem, Kristian" sort="Hveem, Kristian" uniqKey="Hveem K" first="Kristian" last="Hveem">Kristian Hveem</name><affiliation wicri:level="1"><nlm:affiliation>Nord-Trøndelag Health Study Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Levanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Nord-Trøndelag Health Study Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Levanger</wicri:regionArea></affiliation></author><author><name sortKey="N Ss, Marit" sort="N Ss, Marit" uniqKey="N Ss M" first="Marit" last="N Ss">Marit N Ss</name><affiliation wicri:level="1"><nlm:affiliation>Nord-Trøndelag Health Study Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Levanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Nord-Trøndelag Health Study Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Levanger</wicri:regionArea></affiliation></author><author><name sortKey="Sesso, Howard D" sort="Sesso, Howard D" uniqKey="Sesso H" first="Howard D" last="Sesso">Howard D. Sesso</name><affiliation><nlm:affiliation>Divisions of Preventive Medicine and.</nlm:affiliation><wicri:noCountry code="no comma">Divisions of Preventive Medicine and.</wicri:noCountry></affiliation></author><author><name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J Michael" last="Gaziano">J Michael Gaziano</name><affiliation wicri:level="2"><nlm:affiliation>Aging, Brigham and Women's Hospital, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Aging, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Buring, Julie E" sort="Buring, Julie E" uniqKey="Buring J" first="Julie E" last="Buring">Julie E. Buring</name><affiliation><nlm:affiliation>Divisions of Preventive Medicine and.</nlm:affiliation><wicri:noCountry code="no comma">Divisions of Preventive Medicine and.</wicri:noCountry></affiliation></author><author><name sortKey="Lee, I Min" sort="Lee, I Min" uniqKey="Lee I" first="I-Min" last="Lee">I-Min Lee</name><affiliation><nlm:affiliation>Divisions of Preventive Medicine and.</nlm:affiliation><wicri:noCountry code="no comma">Divisions of Preventive Medicine and.</wicri:noCountry></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation wicri:level="1"><nlm:affiliation>Human Genetics Foundation, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Human Genetics Foundation, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Xuehong" sort="Zhang, Xuehong" uniqKey="Zhang X" first="Xuehong" last="Zhang">Xuehong Zhang</name><affiliation wicri:level="2"><nlm:affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Han, Jiali" sort="Han, Jiali" uniqKey="Han J" first="Jiali" last="Han">Jiali Han</name><affiliation><nlm:affiliation>Departments of Epidemiology and.</nlm:affiliation><wicri:noCountry code="no comma">Departments of Epidemiology and.</wicri:noCountry></affiliation></author><author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J" last="Stampfer">Meir J. Stampfer</name><affiliation><nlm:affiliation>Departments of Epidemiology and.</nlm:affiliation><wicri:noCountry code="no comma">Departments of Epidemiology and.</wicri:noCountry></affiliation></author><author><name sortKey="Smith Warner, Stephanie A" sort="Smith Warner, Stephanie A" uniqKey="Smith Warner S" first="Stephanie A" last="Smith-Warner">Stephanie A. Smith-Warner</name><affiliation><nlm:affiliation>Departments of Epidemiology and.</nlm:affiliation><wicri:noCountry code="no comma">Departments of Epidemiology and.</wicri:noCountry></affiliation></author><author><name sortKey="Zeleniuch Jacquotte, Anne" sort="Zeleniuch Jacquotte, Anne" uniqKey="Zeleniuch Jacquotte A" first="Anne" last="Zeleniuch-Jacquotte">Anne Zeleniuch-Jacquotte</name><affiliation wicri:level="2"><nlm:affiliation>Department of Population Health, New York University School of Medicine, New York, NY.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Population Health, New York University School of Medicine, New York</wicri:cityArea></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="2"><nlm:affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Epidemiology Program, University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Butler, Lesley M" sort="Butler, Lesley M" uniqKey="Butler L" first="Lesley M" last="Butler">Lesley M. Butler</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Koh, Woon Puay" sort="Koh, Woon Puay" uniqKey="Koh W" first="Woon-Puay" last="Koh">Woon-Puay Koh</name><affiliation wicri:level="1"><nlm:affiliation>Duke-National University of Singapore (NSU) Medical School, Singapore, and Saw Swee Hock School of Public Health, NSU, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-National University of Singapore (NSU) Medical School, Singapore, and Saw Swee Hock School of Public Health, NSU, Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Renwei" sort="Wang, Renwei" uniqKey="Wang R" first="Renwei" last="Wang">Renwei Wang</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Ericson, Ulrika" sort="Ericson, Ulrika" uniqKey="Ericson U" first="Ulrika" last="Ericson">Ulrika Ericson</name><affiliation wicri:level="1"><nlm:affiliation>Department of clinical sciences Malmö, Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of clinical sciences Malmö, Lund University, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Sonestedt, Emily" sort="Sonestedt, Emily" uniqKey="Sonestedt E" first="Emily" last="Sonestedt">Emily Sonestedt</name><affiliation wicri:level="1"><nlm:affiliation>Department of clinical sciences Malmö, Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of clinical sciences Malmö, Lund University, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G" last="Ziegler">Regina G. Ziegler</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Freedman, Neal D" sort="Freedman, Neal D" uniqKey="Freedman N" first="Neal D" last="Freedman">Neal D. Freedman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Visvanathan, Kala" sort="Visvanathan, Kala" uniqKey="Visvanathan K" first="Kala" last="Visvanathan">Kala Visvanathan</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Sidney Kimmel Comprehensive Center, School of Medicine, Baltimore, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Sidney Kimmel Comprehensive Center, School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Jones, Miranda R" sort="Jones, Miranda R" uniqKey="Jones M" first="Miranda R" last="Jones">Miranda R. Jones</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Sidney Kimmel Comprehensive Center, School of Medicine, Baltimore, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Sidney Kimmel Comprehensive Center, School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Relton, Caroline" sort="Relton, Caroline" uniqKey="Relton C" first="Caroline" last="Relton">Caroline Relton</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Genetic Medicine, Newcastle University, Newcastle</wicri:regionArea></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Ueland, Per M" sort="Ueland, Per M" uniqKey="Ueland P" first="Per M" last="Ueland">Per M. Ueland</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Science, University of Bergen, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Clinical Science, University of Bergen, Bergen</wicri:regionArea></affiliation></author></analytic><series><title level="j">The American journal of clinical nutrition</title><idno type="eISSN">1938-3207</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Asia</term><term>Australia</term><term>Biomarkers (blood)</term><term>Carbon (blood)</term><term>Cross-Sectional Studies</term><term>Dietary Supplements</term><term>Female</term><term>Humans</term><term>Kynurenine (blood)</term><term>Laboratories</term><term>Male</term><term>Middle Aged</term><term>Scandinavian and Nordic Countries</term><term>Tryptophan (blood)</term><term>United States</term><term>Vitamin A (blood)</term><term>Vitamin B Complex (blood)</term><term>Vitamin D (blood)</term><term>alpha-Tocopherol (blood)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Asie</term><term>Australie</term><term>Carbone (sang)</term><term>Complexe vitaminique B (sang)</term><term>Compléments alimentaires</term><term>Cynurénine (sang)</term><term>Femelle</term><term>Humains</term><term>Laboratoires</term><term>Marqueurs biologiques (sang)</term><term>Mâle</term><term>Pays nordiques et scandinaves</term><term>Rétinol (sang)</term><term>Sujet âgé</term><term>Tryptophane (sang)</term><term>Vitamine D (sang)</term><term>alpha-Tocophérol (sang)</term><term>États-Unis d'Amérique</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Carbon</term><term>Kynurenine</term><term>Tryptophan</term><term>Vitamin A</term><term>Vitamin B Complex</term><term>Vitamin D</term><term>alpha-Tocopherol</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Carbone</term><term>Complexe vitaminique B</term><term>Cynurénine</term><term>Marqueurs biologiques</term><term>Rétinol</term><term>Tryptophane</term><term>Vitamine D</term><term>alpha-Tocophérol</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Asia</term><term>Australia</term><term>Cross-Sectional Studies</term><term>Dietary Supplements</term><term>Female</term><term>Humans</term><term>Laboratories</term><term>Male</term><term>Middle Aged</term><term>Scandinavian and Nordic Countries</term><term>United States</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Asie</term><term>Australie</term><term>Compléments alimentaires</term><term>Femelle</term><term>Humains</term><term>Laboratoires</term><term>Mâle</term><term>Pays nordiques et scandinaves</term><term>Sujet âgé</term><term>États-Unis d'Amérique</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Circulating concentrations of biomarkers that are related to vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies.Objective: We robustly and comprehensively assessed differences in biomarkers that are related to vitamin status across geographic regions.Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory.Results: Circulating concentrations of riboflavin, pyridoxal 5'-phosphate, folate, vitamin B-12, all-trans retinol, 25-hydroxyvitamin D, and α-tocopherol as well as combined vitamin scores that were based on these nutrients showed that the general B-vitamin concentration was highest in the United States and that the B vitamins and lipid soluble vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-vitamin concentration in the United States appears to be driven mainly by multivitamin-supplement users.Conclusions: The observed differences likely reflect the variation in intake of vitamins and, in particular, the widespread multivitamin-supplement use in the United States. The results provide valuable information about the differences in biomarker concentrations in populations across continents.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28424186</PMID><DateCreated><Year>2017</Year><Month>04</Month><Day>20</Day></DateCreated><DateCompleted><Year>2017</Year><Month>07</Month><Day>31</Day></DateCompleted><DateRevised><Year>2017</Year><Month>10</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1938-3207</ISSN><JournalIssue CitedMedium="Internet"><Volume>105</Volume><Issue>6</Issue><PubDate><Year>2017</Year><Month>Jun</Month></PubDate></JournalIssue><Title>The American journal of clinical nutrition</Title><ISOAbbreviation>Am. J. Clin. Nutr.</ISOAbbreviation></Journal><ArticleTitle>Circulating concentrations of biomarkers and metabolites related to vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations.</ArticleTitle><Pagination><MedlinePgn>1314-1326</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3945/ajcn.116.151241</ELocationID><Abstract><AbstractText>Background: Circulating concentrations of biomarkers that are related to vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies.Objective: We robustly and comprehensively assessed differences in biomarkers that are related to vitamin status across geographic regions.Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory.Results: Circulating concentrations of riboflavin, pyridoxal 5'-phosphate, folate, vitamin B-12, all-trans retinol, 25-hydroxyvitamin D, and α-tocopherol as well as combined vitamin scores that were based on these nutrients showed that the general B-vitamin concentration was highest in the United States and that the B vitamins and lipid soluble vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-vitamin concentration in the United States appears to be driven mainly by multivitamin-supplement users.Conclusions: The observed differences likely reflect the variation in intake of vitamins and, in particular, the widespread multivitamin-supplement use in the United States. The results provide valuable information about the differences in biomarker concentrations in populations across continents.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Midttun</LastName><ForeName>Øivind</ForeName><Initials>Ø</Initials><AffiliationInfo><Affiliation>Bevital AS, Bergen, Norway; nkjbm@uib.no.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Theofylaktopoulou</LastName><ForeName>Despoina</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Clinical Science, University of Bergen, Bergen, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCann</LastName><ForeName>Adrian</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Bevital AS, Bergen, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fanidi</LastName><ForeName>Anouar</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muller</LastName><ForeName>David C</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meyer</LastName><ForeName>Klaus</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Bevital AS, Bergen, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ulvik</LastName><ForeName>Arve</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Bevital AS, Bergen, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shu</LastName><ForeName>Xiao-Ou</ForeName><Initials>XO</Initials><AffiliationInfo><Affiliation>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiang</LastName><ForeName>Yong-Bing</ForeName><Initials>YB</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prentice</LastName><ForeName>Ross</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomson</LastName><ForeName>Cynthia A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pettinger</LastName><ForeName>Mary</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giles</LastName><ForeName>Graham G</ForeName><Initials>GG</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Center, Cancer Council Victoria, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hodge</LastName><ForeName>Allison</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Center, Cancer Council Victoria, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cai</LastName><ForeName>Qiuyin</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blot</LastName><ForeName>William J</ForeName><Initials>WJ</Initials><AffiliationInfo><Affiliation>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>International Epidemiology Institute, Rockville, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Jie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johansson</LastName><ForeName>Mikael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Radiation Sciences, Oncology, and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hultdin</LastName><ForeName>Johan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grankvist</LastName><ForeName>Kjell</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stevens</LastName><ForeName>Victoria L</ForeName><Initials>VL</Initials><AffiliationInfo><Affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, GA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCullough</LastName><ForeName>Marjorie L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, GA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weinstein</LastName><ForeName>Stephanie J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Albanes</LastName><ForeName>Demetrius</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Langhammer</LastName><ForeName>Arnulf</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Nord-Trøndelag Health Study Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Levanger, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hveem</LastName><ForeName>Kristian</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Nord-Trøndelag Health Study Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Levanger, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Næss</LastName><ForeName>Marit</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Nord-Trøndelag Health Study Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Levanger, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sesso</LastName><ForeName>Howard D</ForeName><Initials>HD</Initials><AffiliationInfo><Affiliation>Divisions of Preventive Medicine and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Aging, Brigham and Women's Hospital, Boston, MA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Departments of Epidemiology and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaziano</LastName><ForeName>J Michael</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Aging, Brigham and Women's Hospital, Boston, MA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>VA Boston Healthcare System, Boston, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buring</LastName><ForeName>Julie E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Divisions of Preventive Medicine and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Departments of Epidemiology and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>I-Min</ForeName><Initials>IM</Initials><AffiliationInfo><Affiliation>Divisions of Preventive Medicine and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Departments of Epidemiology and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Severi</LastName><ForeName>Gianluca</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Human Genetics Foundation, Turin, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Research in Epidemiology and Population Health (U1018 French National Institute of Health and Medical Research), Facultés de Médecine Université Paris-Sud, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Xuehong</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Han</LastName><ForeName>Jiali</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Departments of Epidemiology and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stampfer</LastName><ForeName>Meir J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Departments of Epidemiology and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith-Warner</LastName><ForeName>Stephanie A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Departments of Epidemiology and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeleniuch-Jacquotte</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Population Health, New York University School of Medicine, New York, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>le Marchand</LastName><ForeName>Loic</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yuan</LastName><ForeName>Jian-Min</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Butler</LastName><ForeName>Lesley M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koh</LastName><ForeName>Woon-Puay</ForeName><Initials>WP</Initials><AffiliationInfo><Affiliation>Duke-National University of Singapore (NSU) Medical School, Singapore, and Saw Swee Hock School of Public Health, NSU, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Renwei</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Yu-Tang</ForeName><Initials>YT</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ericson</LastName><ForeName>Ulrika</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Department of clinical sciences Malmö, Lund University, Lund, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sonestedt</LastName><ForeName>Emily</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of clinical sciences Malmö, Lund University, Lund, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ziegler</LastName><ForeName>Regina G</ForeName><Initials>RG</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Freedman</LastName><ForeName>Neal D</ForeName><Initials>ND</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Visvanathan</LastName><ForeName>Kala</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Sidney Kimmel Comprehensive Center, School of Medicine, Baltimore, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jones</LastName><ForeName>Miranda R</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Sidney Kimmel Comprehensive Center, School of Medicine, Baltimore, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Relton</LastName><ForeName>Caroline</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brennan</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johansson</LastName><ForeName>Mattias</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ueland</LastName><ForeName>Per M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Department of Clinical Science, University of Bergen, Bergen, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 CA092447</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA173640</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA182910</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 CA071789</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>A19169</GrantID><Agency>Cancer Research UK</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>04</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Clin Nutr</MedlineTA><NlmUniqueID>0376027</NlmUniqueID><ISSNLinking>0002-9165</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>11103-57-4</RegistryNumber><NameOfSubstance UI="D014801">Vitamin A</NameOfSubstance></Chemical><Chemical><RegistryNumber>12001-76-2</RegistryNumber><NameOfSubstance UI="D014803">Vitamin B Complex</NameOfSubstance></Chemical><Chemical><RegistryNumber>1406-16-2</RegistryNumber><NameOfSubstance UI="D014807">Vitamin D</NameOfSubstance></Chemical><Chemical><RegistryNumber>343-65-7</RegistryNumber><NameOfSubstance UI="D007737">Kynurenine</NameOfSubstance></Chemical><Chemical><RegistryNumber>7440-44-0</RegistryNumber><NameOfSubstance UI="D002244">Carbon</NameOfSubstance></Chemical><Chemical><RegistryNumber>8DUH1N11BX</RegistryNumber><NameOfSubstance UI="D014364">Tryptophan</NameOfSubstance></Chemical><Chemical><RegistryNumber>H4N855PNZ1</RegistryNumber><NameOfSubstance UI="D024502">alpha-Tocopherol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Rapid Commun Mass Spectrom. 2011 Jul 30;25(14):1942-8</RefSource><PMID Version="1">21698677</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Age Ageing. 2004 Jan;33(1):34-41</RefSource><PMID Version="1">14695861</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Public 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MajorTopicYN="N">Australia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002244" MajorTopicYN="N">Carbon</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019587" MajorTopicYN="N">Dietary Supplements</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007737" MajorTopicYN="N">Kynurenine</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007753" MajorTopicYN="N">Laboratories</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012537" MajorTopicYN="N">Scandinavian and Nordic Countries</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014364" MajorTopicYN="N">Tryptophan</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014481" MajorTopicYN="N">United States</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014801" MajorTopicYN="N">Vitamin A</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014803" MajorTopicYN="N">Vitamin B Complex</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014807" MajorTopicYN="N">Vitamin D</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D024502" MajorTopicYN="N">alpha-Tocopherol</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Lung Cancer Cohort Consortium</Keyword><Keyword MajorTopicYN="N">biomarker</Keyword><Keyword MajorTopicYN="N">one-carbon metabolism</Keyword><Keyword MajorTopicYN="N">tryptophan metabolism</Keyword><Keyword MajorTopicYN="N">vitamin status</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>12</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>03</Month><Day>16</Day></PubMedPubDate><PubMedPubDate 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