Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals.
Identifieur interne : 000A33 ( PubMed/Curation ); précédent : 000A32; suivant : 000A34Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals.
Auteurs : Simona D. Frederiksen [Danemark] ; Peter Karlskov-Mortensen [Danemark] ; Sameer D. Pant [Australie] ; Maryse Guerin [France] ; Philippe Lesnik [France] ; Claus B. J Rgensen [Danemark] ; Susanna Cirera [Danemark] ; Camilla S. Bruun [Danemark] ; Thomas Mark [Danemark] ; Merete Fredholm [Danemark]Source :
- PloS one [ 1932-6203 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Obésité, Suidae.
- métabolisme : Obésité.
- Animaux, Cartographie chromosomique, Haplotypes, Polymorphisme de nucléotide simple, Porc miniature, Étude d'association pangénomique.
English descriptors
- KwdEn :
- MESH :
- genetics : Obesity, Swine.
- metabolism : Obesity.
- Animals, Chromosome Mapping, Genome-Wide Association Study, Haplotypes, Polymorphism, Single Nucleotide, Swine, Miniature.
Abstract
We have established a pig resource population specifically designed to elucidate the genetics involved in development of obesity and obesity related co-morbidities by crossing the obesity prone Göttingen Minipig breed with two lean production pig breeds. In this study we have performed genome wide association (GWA) to identify loci with effect on blood lipid levels. The most significantly associated single nucleotide polymorphisms (SNPs) were used for linkage disequilibrium (LD) and haplotype analyses. Three separate haploblocks which influence the ratio between high density lipoprotein cholesterol and total cholesterol (HDL-C/CT), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) levels respectively were identified on Sus Scrofa chromosome 3 (SSC3). Large additive genetic effects were found for the HDL-C/CT and LDL-C haplotypes. Haplotypes segregating from Göttingen Minipigs were shown to impose a positive effect on blood lipid levels. Thus, the genetic profile of the Göttingen Minipig breed seems to support a phenotype comparable to the metabolic healthy obese (MHO) phenotype in humans.
DOI: 10.1371/journal.pone.0178828
PubMed: 28570654
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000A36
Links to Exploration step
pubmed:28570654Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals.</title><author><name sortKey="Frederiksen, Simona D" sort="Frederiksen, Simona D" uniqKey="Frederiksen S" first="Simona D" last="Frederiksen">Simona D. Frederiksen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Karlskov Mortensen, Peter" sort="Karlskov Mortensen, Peter" uniqKey="Karlskov Mortensen P" first="Peter" last="Karlskov-Mortensen">Peter Karlskov-Mortensen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Pant, Sameer D" sort="Pant, Sameer D" uniqKey="Pant S" first="Sameer D" last="Pant">Sameer D. Pant</name><affiliation wicri:level="1"><nlm:affiliation>School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga</wicri:regionArea></affiliation></author><author><name sortKey="Guerin, Maryse" sort="Guerin, Maryse" uniqKey="Guerin M" first="Maryse" last="Guerin">Maryse Guerin</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S1166, Integrative Biology of Atherosclerosis Team, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S1166, Integrative Biology of Atherosclerosis Team, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Lesnik, Philippe" sort="Lesnik, Philippe" uniqKey="Lesnik P" first="Philippe" last="Lesnik">Philippe Lesnik</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S1166, Integrative Biology of Atherosclerosis Team, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S1166, Integrative Biology of Atherosclerosis Team, Paris</wicri:regionArea></affiliation></author><author><name sortKey="J Rgensen, Claus B" sort="J Rgensen, Claus B" uniqKey="J Rgensen C" first="Claus B" last="J Rgensen">Claus B. J Rgensen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Cirera, Susanna" sort="Cirera, Susanna" uniqKey="Cirera S" first="Susanna" last="Cirera">Susanna Cirera</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Bruun, Camilla S" sort="Bruun, Camilla S" uniqKey="Bruun C" first="Camilla S" last="Bruun">Camilla S. Bruun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Mark, Thomas" sort="Mark, Thomas" uniqKey="Mark T" first="Thomas" last="Mark">Thomas Mark</name><affiliation wicri:level="1"><nlm:affiliation>Novo Nordisk, Scandinavia AB, Region Denmark, Maaloev, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Novo Nordisk, Scandinavia AB, Region Denmark, Maaloev</wicri:regionArea></affiliation></author><author><name sortKey="Fredholm, Merete" sort="Fredholm, Merete" uniqKey="Fredholm M" first="Merete" last="Fredholm">Merete Fredholm</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28570654</idno><idno type="pmid">28570654</idno><idno type="doi">10.1371/journal.pone.0178828</idno><idno type="wicri:Area/PubMed/Corpus">000A36</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A36</idno><idno type="wicri:Area/PubMed/Curation">000A33</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A33</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals.</title><author><name sortKey="Frederiksen, Simona D" sort="Frederiksen, Simona D" uniqKey="Frederiksen S" first="Simona D" last="Frederiksen">Simona D. Frederiksen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Karlskov Mortensen, Peter" sort="Karlskov Mortensen, Peter" uniqKey="Karlskov Mortensen P" first="Peter" last="Karlskov-Mortensen">Peter Karlskov-Mortensen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Pant, Sameer D" sort="Pant, Sameer D" uniqKey="Pant S" first="Sameer D" last="Pant">Sameer D. Pant</name><affiliation wicri:level="1"><nlm:affiliation>School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga</wicri:regionArea></affiliation></author><author><name sortKey="Guerin, Maryse" sort="Guerin, Maryse" uniqKey="Guerin M" first="Maryse" last="Guerin">Maryse Guerin</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S1166, Integrative Biology of Atherosclerosis Team, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S1166, Integrative Biology of Atherosclerosis Team, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Lesnik, Philippe" sort="Lesnik, Philippe" uniqKey="Lesnik P" first="Philippe" last="Lesnik">Philippe Lesnik</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S1166, Integrative Biology of Atherosclerosis Team, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S1166, Integrative Biology of Atherosclerosis Team, Paris</wicri:regionArea></affiliation></author><author><name sortKey="J Rgensen, Claus B" sort="J Rgensen, Claus B" uniqKey="J Rgensen C" first="Claus B" last="J Rgensen">Claus B. J Rgensen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Cirera, Susanna" sort="Cirera, Susanna" uniqKey="Cirera S" first="Susanna" last="Cirera">Susanna Cirera</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Bruun, Camilla S" sort="Bruun, Camilla S" uniqKey="Bruun C" first="Camilla S" last="Bruun">Camilla S. Bruun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Mark, Thomas" sort="Mark, Thomas" uniqKey="Mark T" first="Thomas" last="Mark">Thomas Mark</name><affiliation wicri:level="1"><nlm:affiliation>Novo Nordisk, Scandinavia AB, Region Denmark, Maaloev, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Novo Nordisk, Scandinavia AB, Region Denmark, Maaloev</wicri:regionArea></affiliation></author><author><name sortKey="Fredholm, Merete" sort="Fredholm, Merete" uniqKey="Fredholm M" first="Merete" last="Fredholm">Merete Fredholm</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chromosome Mapping</term><term>Genome-Wide Association Study</term><term>Haplotypes</term><term>Obesity (genetics)</term><term>Obesity (metabolism)</term><term>Polymorphism, Single Nucleotide</term><term>Swine (genetics)</term><term>Swine, Miniature</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cartographie chromosomique</term><term>Haplotypes</term><term>Obésité (génétique)</term><term>Obésité (métabolisme)</term><term>Polymorphisme de nucléotide simple</term><term>Porc miniature</term><term>Suidae (génétique)</term><term>Étude d'association pangénomique</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Obesity</term><term>Swine</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Obésité</term><term>Suidae</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Obésité</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chromosome Mapping</term><term>Genome-Wide Association Study</term><term>Haplotypes</term><term>Polymorphism, Single Nucleotide</term><term>Swine, Miniature</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cartographie chromosomique</term><term>Haplotypes</term><term>Polymorphisme de nucléotide simple</term><term>Porc miniature</term><term>Étude d'association pangénomique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have established a pig resource population specifically designed to elucidate the genetics involved in development of obesity and obesity related co-morbidities by crossing the obesity prone Göttingen Minipig breed with two lean production pig breeds. In this study we have performed genome wide association (GWA) to identify loci with effect on blood lipid levels. The most significantly associated single nucleotide polymorphisms (SNPs) were used for linkage disequilibrium (LD) and haplotype analyses. Three separate haploblocks which influence the ratio between high density lipoprotein cholesterol and total cholesterol (HDL-C/CT), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) levels respectively were identified on Sus Scrofa chromosome 3 (SSC3). Large additive genetic effects were found for the HDL-C/CT and LDL-C haplotypes. Haplotypes segregating from Göttingen Minipigs were shown to impose a positive effect on blood lipid levels. Thus, the genetic profile of the Göttingen Minipig breed seems to support a phenotype comparable to the metabolic healthy obese (MHO) phenotype in humans.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28570654</PMID><DateCreated><Year>2017</Year><Month>06</Month><Day>01</Day></DateCreated><DateCompleted><Year>2017</Year><Month>09</Month><Day>28</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>12</Volume><Issue>6</Issue><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals.</ArticleTitle><Pagination><MedlinePgn>e0178828</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0178828</ELocationID><Abstract><AbstractText>We have established a pig resource population specifically designed to elucidate the genetics involved in development of obesity and obesity related co-morbidities by crossing the obesity prone Göttingen Minipig breed with two lean production pig breeds. In this study we have performed genome wide association (GWA) to identify loci with effect on blood lipid levels. The most significantly associated single nucleotide polymorphisms (SNPs) were used for linkage disequilibrium (LD) and haplotype analyses. Three separate haploblocks which influence the ratio between high density lipoprotein cholesterol and total cholesterol (HDL-C/CT), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) levels respectively were identified on Sus Scrofa chromosome 3 (SSC3). Large additive genetic effects were found for the HDL-C/CT and LDL-C haplotypes. Haplotypes segregating from Göttingen Minipigs were shown to impose a positive effect on blood lipid levels. Thus, the genetic profile of the Göttingen Minipig breed seems to support a phenotype comparable to the metabolic healthy obese (MHO) phenotype in humans.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Frederiksen</LastName><ForeName>Simona D</ForeName><Initials>SD</Initials><AffiliationInfo><Affiliation>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karlskov-Mortensen</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pant</LastName><ForeName>Sameer D</ForeName><Initials>SD</Initials><AffiliationInfo><Affiliation>School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guerin</LastName><ForeName>Maryse</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>INSERM UMR_S1166, Integrative Biology of Atherosclerosis Team, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lesnik</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>INSERM UMR_S1166, Integrative Biology of Atherosclerosis Team, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jørgensen</LastName><ForeName>Claus B</ForeName><Initials>CB</Initials><AffiliationInfo><Affiliation>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cirera</LastName><ForeName>Susanna</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bruun</LastName><ForeName>Camilla S</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mark</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Novo Nordisk, Scandinavia AB, Region Denmark, Maaloev, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fredholm</LastName><ForeName>Merete</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-3563-7648</Identifier><AffiliationInfo><Affiliation>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>06</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>BMC Genomics. 2014 Sep 04;15:758</RefSource><PMID Version="1">25189197</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Lipid Res. 1998 Apr;39(4):777-88</RefSource><PMID Version="1">9555943</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2013 Nov;45(11):1274-83</RefSource><PMID Version="1">24097068</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Anim Ecol. 2010 Jan;79(1):13-26</RefSource><PMID Version="1">20409158</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genet Epidemiol. 2010 Jan;34(1):100-5</RefSource><PMID Version="1">19434714</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Public Health. 2014 Jan 08;14:14</RefSource><PMID Version="1">24400816</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Biol. 2004 Dec;2(12):e393</RefSource><PMID Version="1">15534693</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2007 May 15;23(10):1294-6</RefSource><PMID Version="1">17384015</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem Pharmacol. 2004 Jan 15;67(2):303-13</RefSource><PMID Version="1">14698043</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genet Sel Evol. 2016 Mar 29;48:23</RefSource><PMID Version="1">27025270</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2016 Jun;48(6):634-9</RefSource><PMID Version="1">27135400</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Diabetes Res. 2013;2013:761415</RefSource><PMID Version="1">23844374</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genet Epidemiol. 2011 Apr;35(3):154-8</RefSource><PMID Version="1">21254223</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Anim Genet. 2014 Feb;45(1):59-66</RefSource><PMID Version="1">24033492</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Biol Sci. 2007 Feb 10;3(3):179-84</RefSource><PMID Version="1">17384736</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Physiol Regul Integr Comp Physiol. 2009 Oct;297(4):R1195-201</RefSource><PMID Version="1">19710388</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Obesity (Silver Spring). 2013 Jan;21(1):149-58</RefSource><PMID Version="1">23505180</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Diabetologia. 2005 Nov;48(11):2203-5</RefSource><PMID Version="1">16193286</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Circulation. 2014 Jan 21;129(3):e28-e292</RefSource><PMID Version="1">24352519</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Nutr Food Res. 2015 Jan;59(1):75-93</RefSource><PMID Version="1">25418549</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Cardiol. 2016 Feb;13(2):74-5</RefSource><PMID Version="1">26763537</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Circ Res. 2005 Jan 7;96(1):27-42</RefSource><PMID Version="1">15637305</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2010 Aug 5;466(7307):707-13</RefSource><PMID Version="1">20686565</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Lipidol. 2010 Feb;21(1):38-43</RefSource><PMID Version="1">19915462</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2002 Jun 21;296(5576):2225-9</RefSource><PMID Version="1">12029063</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Endocrinol Metab. 2012 Jul;97(7):2482-8</RefSource><PMID Version="1">22508708</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genetics. 2007 Sep;177(1):577-85</RefSource><PMID Version="1">17660554</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Asia Pac J Clin Nutr. 2012;21(2):227-33</RefSource><PMID Version="1">22507609</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2005 Jan 15;21(2):263-5</RefSource><PMID Version="1">15297300</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 1986 Dec 19;234(4783):1573-7</RefSource><PMID Version="1">3787263</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 1991 Jul;139(1):139-47</RefSource><PMID Version="1">1853929</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genet Epidemiol. 2008 May;32(4):361-9</RefSource><PMID Version="1">18271029</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Comp Med. 2001 Apr;51(2):150-5</RefSource><PMID Version="1">11922179</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2015 Jun 29;10(6):e0131667</RefSource><PMID Version="1">26121138</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Genet. 2013 Mar 18;4:29</RefSource><PMID Version="1">23515185</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 2007 Sep;81(3):559-75</RefSource><PMID Version="1">17701901</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 2007 Nov;81(5):913-26</RefSource><PMID Version="1">17924335</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lab Anim. 2005 Jan;39(1):80-93</RefSource><PMID Version="1">15703128</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2015 Sep 08;10(9):e0137356</RefSource><PMID Version="1">26348622</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eat Weight Disord. 2016 Jun;21(2):165-74</RefSource><PMID Version="1">27043948</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2006 Feb;38(2):218-22</RefSource><PMID Version="1">16429159</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochim Biophys Acta. 2014 Oct;1842(10):1993-2009</RefSource><PMID Version="1">24798233</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2007 Dec 05;2(12):e1274</RefSource><PMID Version="1">18060068</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 1954 Jul-Aug;30(4):851-5</RefSource><PMID Version="1">13180692</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002874" MajorTopicYN="Y">Chromosome Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055106" MajorTopicYN="N">Genome-Wide Association Study</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006239" MajorTopicYN="Y">Haplotypes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009765" MajorTopicYN="N">Obesity</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013556" MajorTopicYN="N">Swine, Miniature</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>01</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>05</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>6</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>6</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28570654</ArticleId><ArticleId IdType="doi">10.1371/journal.pone.0178828</ArticleId><ArticleId IdType="pii">PONE-D-17-00264</ArticleId><ArticleId IdType="pmc">PMC5453593</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A33 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000A33 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:28570654
|texte= Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:28570654" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |