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Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017.

Identifieur interne : 000A11 ( PubMed/Curation ); précédent : 000A10; suivant : 000A12

Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017.

Auteurs : Silke Gillessen [Suisse] ; Gerhardt Attard [Royaume-Uni] ; Tomasz M. Beer [États-Unis] ; Himisha Beltran [États-Unis] ; Alberto Bossi [France] ; Rob Bristow [États-Unis] ; Brett Carver [États-Unis] ; Daniel Castellano [Espagne] ; Byung Ha Chung [Corée du Sud] ; Noel Clarke [Royaume-Uni] ; Gedske Daugaard [Danemark] ; Ian D. Davis [Australie] ; Johann De Bono [Royaume-Uni] ; Rodolfo Borges Dos Reis [Brésil] ; Charles G. Drake [États-Unis] ; Ros Eeles [Royaume-Uni] ; Eleni Efstathiou [États-Unis] ; Christopher P. Evans [États-Unis] ; Stefano Fanti [Italie] ; Felix Feng [États-Unis] ; Karim Fizazi [France] ; Mark Frydenberg ; Martin Gleave [Canada] ; Susan Halabi [États-Unis] ; Axel Heidenreich [Allemagne] ; Celestia S. Higano [États-Unis] ; Nicolas James [Royaume-Uni] ; Philip Kantoff [États-Unis] ; Pirkko-Liisa Kellokumpu-Lehtinen [Finlande] ; Raja B. Khauli [Liban] ; Gero Kramer [Autriche] ; Chris Logothetis [États-Unis] ; Fernando Maluf ; Alicia K. Morgans [États-Unis] ; Michael J. Morris [États-Unis] ; Nicolas Mottet [France] ; Vedang Murthy [Inde] ; William Oh [États-Unis] ; Piet Ost [Belgique] ; Anwar R. Padhani [Royaume-Uni] ; Chris Parker [Royaume-Uni] ; Colin C. Pritchard [États-Unis] ; Mack Roach [États-Unis] ; Mark A. Rubin ; Charles Ryan [États-Unis] ; Fred Saad [Canada] ; Oliver Sartor [États-Unis] ; Howard Scher [États-Unis] ; Avishay Sella [Israël] ; Neal Shore [États-Unis] ; Matthew Smith [États-Unis] ; Howard Soule [États-Unis] ; Cora N. Sternberg [Italie] ; Hiroyoshi Suzuki [Japon] ; Christopher Sweeney [États-Unis] ; Matthew R. Sydes [Royaume-Uni] ; Ian Tannock [Canada] ; Bertrand Tombal [Belgique] ; Riccardo Valdagni [Italie] ; Thomas Wiegel [Allemagne] ; Aurelius Omlin [Suisse]

Source :

RBID : pubmed:28655541

Abstract

In advanced prostate cancer (APC), successful drug development as well as advances in imaging and molecular characterisation have resulted in multiple areas where there is lack of evidence or low level of evidence. The Advanced Prostate Cancer Consensus Conference (APCCC) 2017 addressed some of these topics.

DOI: 10.1016/j.eururo.2017.06.002
PubMed: 28655541

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pubmed:28655541

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Mark Frydenberg
<affiliation>
<nlm:affiliation>Department of Surgery, Department of Anatomy and Developmental Biology, Faculty of Medicine, Nursing and Health Sciences, Monash University.</nlm:affiliation>
<wicri:noCountry code="subField">Monash University</wicri:noCountry>
</affiliation>
Fernando Maluf
<affiliation>
<nlm:affiliation>Department of Medical Oncology Hospital Israelita Albert Einstein and Department of Medical Oncology Beneficência Portuguesa de São Paulo.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Medical Oncology Hospital Israelita Albert Einstein and Department of Medical Oncology Beneficência Portuguesa de São Paulo.</wicri:noCountry>
</affiliation>
Mark A. Rubin
<affiliation>
<nlm:affiliation>Department of Pathology, University of Bern and the Inselspital, Bern (CH).</nlm:affiliation>
<wicri:noCountry code="subField">Bern (CH)</wicri:noCountry>
</affiliation>

Le document en format XML

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<nlm:affiliation>Department of Medical Oncology, The Institute of Cancer Research/Royal Marsden, London, UK.</nlm:affiliation>
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<name sortKey="Dos Reis, Rodolfo Borges" sort="Dos Reis, Rodolfo Borges" uniqKey="Dos Reis R" first="Rodolfo Borges" last="Dos Reis">Rodolfo Borges Dos Reis</name>
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<nlm:affiliation>Department of Urology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.</nlm:affiliation>
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<name sortKey="Drake, Charles G" sort="Drake, Charles G" uniqKey="Drake C" first="Charles G" last="Drake">Charles G. Drake</name>
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<name sortKey="Eeles, Ros" sort="Eeles, Ros" uniqKey="Eeles R" first="Ros" last="Eeles">Ros Eeles</name>
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<name sortKey="Efstathiou, Eleni" sort="Efstathiou, Eleni" uniqKey="Efstathiou E" first="Eleni" last="Efstathiou">Eleni Efstathiou</name>
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<nlm:affiliation>Department of Medical Oncology, University of Texas MD Anderson Cancer Center, TX, USA.</nlm:affiliation>
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<name sortKey="Evans, Christopher P" sort="Evans, Christopher P" uniqKey="Evans C" first="Christopher P" last="Evans">Christopher P. Evans</name>
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<nlm:affiliation>Department of Urology, University of California, Davis School of Medicine, CA, USA.</nlm:affiliation>
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<name sortKey="Fanti, Stefano" sort="Fanti, Stefano" uniqKey="Fanti S" first="Stefano" last="Fanti">Stefano Fanti</name>
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<nlm:affiliation>Department of Nuclear Medicine, Policlinico S. Orsola, Università di Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Nuclear Medicine, Policlinico S. Orsola, Università di Bologna</wicri:regionArea>
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<name sortKey="Feng, Felix" sort="Feng, Felix" uniqKey="Feng F" first="Felix" last="Feng">Felix Feng</name>
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<nlm:affiliation>Department of Radiation Oncology, University of California, San Francisco, CA, USA.</nlm:affiliation>
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<name sortKey="Fizazi, Karim" sort="Fizazi, Karim" uniqKey="Fizazi K" first="Karim" last="Fizazi">Karim Fizazi</name>
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<nlm:affiliation>Department of Medical Oncology, Gustave Roussy, University of Paris Sud, Paris, France.</nlm:affiliation>
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<wicri:regionArea>Department of Medical Oncology, Gustave Roussy, University of Paris Sud, Paris</wicri:regionArea>
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<name sortKey="Frydenberg, Mark" sort="Frydenberg, Mark" uniqKey="Frydenberg M" first="Mark" last="Frydenberg">Mark Frydenberg</name>
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<nlm:affiliation>Department of Surgery, Department of Anatomy and Developmental Biology, Faculty of Medicine, Nursing and Health Sciences, Monash University.</nlm:affiliation>
<wicri:noCountry code="subField">Monash University</wicri:noCountry>
</affiliation>
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<name sortKey="Gleave, Martin" sort="Gleave, Martin" uniqKey="Gleave M" first="Martin" last="Gleave">Martin Gleave</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Urology, Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Urology, Vancouver Prostate Centre, University of British Columbia, Vancouver, BC</wicri:regionArea>
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<name sortKey="Halabi, Susan" sort="Halabi, Susan" uniqKey="Halabi S" first="Susan" last="Halabi">Susan Halabi</name>
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<nlm:affiliation>Department of Clinical trials and Statistics, Duke University, Durham, NC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Clinical trials and Statistics, Duke University, Durham, NC</wicri:regionArea>
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<name sortKey="Heidenreich, Axel" sort="Heidenreich, Axel" uniqKey="Heidenreich A" first="Axel" last="Heidenreich">Axel Heidenreich</name>
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<nlm:affiliation>Department of Urology, University Hospital Köln, Köln, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Urology, University Hospital Köln, Köln</wicri:regionArea>
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<name sortKey="Higano, Celestia S" sort="Higano, Celestia S" uniqKey="Higano C" first="Celestia S" last="Higano">Celestia S. Higano</name>
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<nlm:affiliation>Department of Medicine, Division of Medical Oncology, University of Washington and Fred Hutchinson Cancer Research Center, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Medical Oncology, University of Washington and Fred Hutchinson Cancer Research Center, WA</wicri:regionArea>
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<name sortKey="James, Nicolas" sort="James, Nicolas" uniqKey="James N" first="Nicolas" last="James">Nicolas James</name>
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<nlm:affiliation>Department of Clinical Oncology, Clinical Oncology Queen Elizabeth Hospital Birmingham and University of Birmingham, Birmingham, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Oncology, Clinical Oncology Queen Elizabeth Hospital Birmingham and University of Birmingham, Birmingham</wicri:regionArea>
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<name sortKey="Kantoff, Philip" sort="Kantoff, Philip" uniqKey="Kantoff P" first="Philip" last="Kantoff">Philip Kantoff</name>
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<nlm:affiliation>Department of Medical Oncology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY</wicri:regionArea>
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<name sortKey="Kellokumpu Lehtinen, Pirkko Liisa" sort="Kellokumpu Lehtinen, Pirkko Liisa" uniqKey="Kellokumpu Lehtinen P" first="Pirkko-Liisa" last="Kellokumpu-Lehtinen">Pirkko-Liisa Kellokumpu-Lehtinen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Clinical Oncology, Tampere University Hospital, Faculty of Medicine and Life Sciences, University of Tampere, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
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<name sortKey="Khauli, Raja B" sort="Khauli, Raja B" uniqKey="Khauli R" first="Raja B" last="Khauli">Raja B. Khauli</name>
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<nlm:affiliation>Department of Urology, American University of Beirut Medical Center, Beirut, Lebanon.</nlm:affiliation>
<country xml:lang="fr">Liban</country>
<wicri:regionArea>Department of Urology, American University of Beirut Medical Center, Beirut</wicri:regionArea>
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<name sortKey="Kramer, Gero" sort="Kramer, Gero" uniqKey="Kramer G" first="Gero" last="Kramer">Gero Kramer</name>
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<nlm:affiliation>Department of Urology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Urology, Medical University of Vienna, Vienna</wicri:regionArea>
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<name sortKey="Logothetis, Chris" sort="Logothetis, Chris" uniqKey="Logothetis C" first="Chris" last="Logothetis">Chris Logothetis</name>
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<nlm:affiliation>Department of Genitourinary Medical Oncology, MD Anderson Cancer Centre, Houston, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genitourinary Medical Oncology, MD Anderson Cancer Centre, Houston, TX</wicri:regionArea>
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<name sortKey="Maluf, Fernando" sort="Maluf, Fernando" uniqKey="Maluf F" first="Fernando" last="Maluf">Fernando Maluf</name>
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<nlm:affiliation>Department of Medical Oncology Hospital Israelita Albert Einstein and Department of Medical Oncology Beneficência Portuguesa de São Paulo.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Medical Oncology Hospital Israelita Albert Einstein and Department of Medical Oncology Beneficência Portuguesa de São Paulo.</wicri:noCountry>
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<name sortKey="Morgans, Alicia K" sort="Morgans, Alicia K" uniqKey="Morgans A" first="Alicia K" last="Morgans">Alicia K. Morgans</name>
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<nlm:affiliation>Department of Medical Oncology and Epidemiology, Vanderbilt University Medical Center, Division of Hematology/Oncology, Nashville, TN, USA.</nlm:affiliation>
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<wicri:regionArea>Department of Medical Oncology and Epidemiology, Vanderbilt University Medical Center, Division of Hematology/Oncology, Nashville, TN</wicri:regionArea>
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<name sortKey="Morris, Michael J" sort="Morris, Michael J" uniqKey="Morris M" first="Michael J" last="Morris">Michael J. Morris</name>
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<nlm:affiliation>Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY</wicri:regionArea>
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<name sortKey="Mottet, Nicolas" sort="Mottet, Nicolas" uniqKey="Mottet N" first="Nicolas" last="Mottet">Nicolas Mottet</name>
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<nlm:affiliation>Department of Urology, University Hospital Nord St. Etienne, St. Etienne, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<name sortKey="Murthy, Vedang" sort="Murthy, Vedang" uniqKey="Murthy V" first="Vedang" last="Murthy">Vedang Murthy</name>
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<nlm:affiliation>Department of Radiation Oncology, Tata Memorial Centre, Mumbai, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Radiation Oncology, Tata Memorial Centre, Mumbai</wicri:regionArea>
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<name sortKey="Oh, William" sort="Oh, William" uniqKey="Oh W" first="William" last="Oh">William Oh</name>
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<nlm:affiliation>Department of Medical Oncology, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, The Tisch Cancer Institute, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, The Tisch Cancer Institute, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ost, Piet" sort="Ost, Piet" uniqKey="Ost P" first="Piet" last="Ost">Piet Ost</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Radiation Oncology, Ghent University Hospital, Ghent</wicri:regionArea>
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<name sortKey="Padhani, Anwar R" sort="Padhani, Anwar R" uniqKey="Padhani A" first="Anwar R" last="Padhani">Anwar R. Padhani</name>
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<nlm:affiliation>Department of Radiology, Mount Vernon Cancer Centre and Institute of Cancer Research, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Radiology, Mount Vernon Cancer Centre and Institute of Cancer Research, London</wicri:regionArea>
</affiliation>
</author>
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<name sortKey="Parker, Chris" sort="Parker, Chris" uniqKey="Parker C" first="Chris" last="Parker">Chris Parker</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Clinical Oncology, Royal Marsden NHS Foundation Trust, Sutton, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Oncology, Royal Marsden NHS Foundation Trust, Sutton</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Pritchard, Colin C" sort="Pritchard, Colin C" uniqKey="Pritchard C" first="Colin C" last="Pritchard">Colin C. Pritchard</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Pathology, University of Washington, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, University of Washington, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Roach, Mack" sort="Roach, Mack" uniqKey="Roach M" first="Mack" last="Roach">Mack Roach</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiation Oncology, University of California, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiation Oncology, University of California, San Francisco, CA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rubin, Mark A" sort="Rubin, Mark A" uniqKey="Rubin M" first="Mark A" last="Rubin">Mark A. Rubin</name>
<affiliation>
<nlm:affiliation>Department of Pathology, University of Bern and the Inselspital, Bern (CH).</nlm:affiliation>
<wicri:noCountry code="subField">Bern (CH)</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Ryan, Charles" sort="Ryan, Charles" uniqKey="Ryan C" first="Charles" last="Ryan">Charles Ryan</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Clinical Medicine and Urology at the Helen Diller Family Comprehensive Cancer Center at the University of, California, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Clinical Medicine and Urology at the Helen Diller Family Comprehensive Cancer Center at the University of, California, San Francisco, CA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Saad, Fred" sort="Saad, Fred" uniqKey="Saad F" first="Fred" last="Saad">Fred Saad</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Urology, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Urology, Centre Hospitalier de l'Université de Montréal, Montreal, QC</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sartor, Oliver" sort="Sartor, Oliver" uniqKey="Sartor O" first="Oliver" last="Sartor">Oliver Sartor</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Tulane Cancer Center, New Orleans, LA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Tulane Cancer Center, New Orleans, LA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Scher, Howard" sort="Scher, Howard" uniqKey="Scher H" first="Howard" last="Scher">Howard Scher</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Centre, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Centre, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sella, Avishay" sort="Sella, Avishay" uniqKey="Sella A" first="Avishay" last="Sella">Avishay Sella</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Department of Oncology, Assaf Harofeh Medical Centre, Tel-Aviv University, Sackler School of Medicine, Zerifin, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Medical Oncology, Department of Oncology, Assaf Harofeh Medical Centre, Tel-Aviv University, Sackler School of Medicine, Zerifin</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Shore, Neal" sort="Shore, Neal" uniqKey="Shore N" first="Neal" last="Shore">Neal Shore</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Urology, Carolina Urologic Research Center, Myrtle Beach, SC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Urology, Carolina Urologic Research Center, Myrtle Beach, SC</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Smith, Matthew" sort="Smith, Matthew" uniqKey="Smith M" first="Matthew" last="Smith">Matthew Smith</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Massachusetts General Hospital Cancer Centre, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Massachusetts General Hospital Cancer Centre, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Soule, Howard" sort="Soule, Howard" uniqKey="Soule H" first="Howard" last="Soule">Howard Soule</name>
<affiliation wicri:level="1">
<nlm:affiliation>Prostate Cancer Foundation, Santa Monica, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Prostate Cancer Foundation, Santa Monica, CA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sternberg, Cora N" sort="Sternberg, Cora N" uniqKey="Sternberg C" first="Cora N" last="Sternberg">Cora N. Sternberg</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, San Camillo Forlanini Hospital, Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical Oncology, San Camillo Forlanini Hospital, Rome</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Suzuki, Hiroyoshi" sort="Suzuki, Hiroyoshi" uniqKey="Suzuki H" first="Hiroyoshi" last="Suzuki">Hiroyoshi Suzuki</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Urology, Toho University Sakura Medical Center, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Urology, Toho University Sakura Medical Center</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sweeney, Christopher" sort="Sweeney, Christopher" uniqKey="Sweeney C" first="Christopher" last="Sweeney">Christopher Sweeney</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sydes, Matthew R" sort="Sydes, Matthew R" uniqKey="Sydes M" first="Matthew R" last="Sydes">Matthew R. Sydes</name>
<affiliation wicri:level="1">
<nlm:affiliation>MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tannock, Ian" sort="Tannock, Ian" uniqKey="Tannock I" first="Ian" last="Tannock">Ian Tannock</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Princess Margaret Cancer Centre and University of Toronto, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medical Oncology, Princess Margaret Cancer Centre and University of Toronto, Toronto, ON</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tombal, Bertrand" sort="Tombal, Bertrand" uniqKey="Tombal B" first="Bertrand" last="Tombal">Bertrand Tombal</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Urology, Cliniques Universitaires Saint Luc, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Urology, Cliniques Universitaires Saint Luc, Brussels</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Valdagni, Riccardo" sort="Valdagni, Riccardo" uniqKey="Valdagni R" first="Riccardo" last="Valdagni">Riccardo Valdagni</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Oncology and Haemato-oncology, Università degli Studi di Milano. Radiation Oncology 1, Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Oncology and Haemato-oncology, Università degli Studi di Milano. Radiation Oncology 1, Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wiegel, Thomas" sort="Wiegel, Thomas" uniqKey="Wiegel T" first="Thomas" last="Wiegel">Thomas Wiegel</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiation Oncology, Klinik für Strahlentherapie und Radioonkologie des Universitätsklinikum Ulm, Albert-Einstein-Allee, Ulm, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Radiation Oncology, Klinik für Strahlentherapie und Radioonkologie des Universitätsklinikum Ulm, Albert-Einstein-Allee, Ulm</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Omlin, Aurelius" sort="Omlin, Aurelius" uniqKey="Omlin A" first="Aurelius" last="Omlin">Aurelius Omlin</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Cantonal Hospital St. Gallen and University of Berne, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Medical Oncology, Cantonal Hospital St. Gallen and University of Berne</wicri:regionArea>
</affiliation>
</author>
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<title xml:lang="en">Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017.</title>
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<name sortKey="Gillessen, Silke" sort="Gillessen, Silke" uniqKey="Gillessen S" first="Silke" last="Gillessen">Silke Gillessen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Cantonal Hospital St. Gallen and University of Berne, Switzerland. Electronic address: silke.gillessen@kssg.ch.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Medical Oncology, Cantonal Hospital St. Gallen and University of Berne</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Attard, Gerhardt" sort="Attard, Gerhardt" uniqKey="Attard G" first="Gerhardt" last="Attard">Gerhardt Attard</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, The Institute of Cancer Research/Royal Marsden, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Medical Oncology, The Institute of Cancer Research/Royal Marsden, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Beer, Tomasz M" sort="Beer, Tomasz M" uniqKey="Beer T" first="Tomasz M" last="Beer">Tomasz M. Beer</name>
<affiliation wicri:level="1">
<nlm:affiliation>Oregon Health & Science University Knight Cancer Institute, OR, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Oregon Health & Science University Knight Cancer Institute, OR</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Beltran, Himisha" sort="Beltran, Himisha" uniqKey="Beltran H" first="Himisha" last="Beltran">Himisha Beltran</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Weill Cornell Medicine, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Weill Cornell Medicine, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bossi, Alberto" sort="Bossi, Alberto" uniqKey="Bossi A" first="Alberto" last="Bossi">Alberto Bossi</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiation Oncology, Genito Urinary Oncology, Prostate Brachytherapy Unit, Goustave Roussy, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiation Oncology, Genito Urinary Oncology, Prostate Brachytherapy Unit, Goustave Roussy, Paris</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bristow, Rob" sort="Bristow, Rob" uniqKey="Bristow R" first="Rob" last="Bristow">Rob Bristow</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiation Oncology, Princess Margaret Cancer Centre and University of Toronto, Toronto, ON, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiation Oncology, Princess Margaret Cancer Centre and University of Toronto, Toronto, ON</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Carver, Brett" sort="Carver, Brett" uniqKey="Carver B" first="Brett" last="Carver">Brett Carver</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Castellano, Daniel" sort="Castellano, Daniel" uniqKey="Castellano D" first="Daniel" last="Castellano">Daniel Castellano</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chung, Byung Ha" sort="Chung, Byung Ha" uniqKey="Chung B" first="Byung Ha" last="Chung">Byung Ha Chung</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Urology, Gangnam Severance Hospital, Yonsei University Health System, Seoul, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Urology, Gangnam Severance Hospital, Yonsei University Health System, Seoul</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Clarke, Noel" sort="Clarke, Noel" uniqKey="Clarke N" first="Noel" last="Clarke">Noel Clarke</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Urology, The Christie and Salford Royal Hospitals, Manchester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Urology, The Christie and Salford Royal Hospitals, Manchester</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Daugaard, Gedske" sort="Daugaard, Gedske" uniqKey="Daugaard G" first="Gedske" last="Daugaard">Gedske Daugaard</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Medical Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Davis, Ian D" sort="Davis, Ian D" uniqKey="Davis I" first="Ian D" last="Davis">Ian D. Davis</name>
<affiliation wicri:level="1">
<nlm:affiliation>Monash University and Eastern Health, Eastern Health Clinical School, Box Hill, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Monash University and Eastern Health, Eastern Health Clinical School, Box Hill</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="De Bono, Johann" sort="De Bono, Johann" uniqKey="De Bono J" first="Johann" last="De Bono">Johann De Bono</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, The Institute of Cancer Research/Royal Marsden, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Medical Oncology, The Institute of Cancer Research/Royal Marsden, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Dos Reis, Rodolfo Borges" sort="Dos Reis, Rodolfo Borges" uniqKey="Dos Reis R" first="Rodolfo Borges" last="Dos Reis">Rodolfo Borges Dos Reis</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Urology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Urology, Ribeirão Preto Medical School, University of São Paulo, São Paulo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Drake, Charles G" sort="Drake, Charles G" uniqKey="Drake C" first="Charles G" last="Drake">Charles G. Drake</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Division of Haematology/Oncology, Columbia University Medical Center, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Division of Haematology/Oncology, Columbia University Medical Center, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Eeles, Ros" sort="Eeles, Ros" uniqKey="Eeles R" first="Ros" last="Eeles">Ros Eeles</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Clinical Oncology and Genetics, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Oncology and Genetics, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Efstathiou, Eleni" sort="Efstathiou, Eleni" uniqKey="Efstathiou E" first="Eleni" last="Efstathiou">Eleni Efstathiou</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, University of Texas MD Anderson Cancer Center, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, University of Texas MD Anderson Cancer Center, TX</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Evans, Christopher P" sort="Evans, Christopher P" uniqKey="Evans C" first="Christopher P" last="Evans">Christopher P. Evans</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Urology, University of California, Davis School of Medicine, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Urology, University of California, Davis School of Medicine, CA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fanti, Stefano" sort="Fanti, Stefano" uniqKey="Fanti S" first="Stefano" last="Fanti">Stefano Fanti</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Nuclear Medicine, Policlinico S. Orsola, Università di Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Nuclear Medicine, Policlinico S. Orsola, Università di Bologna</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Feng, Felix" sort="Feng, Felix" uniqKey="Feng F" first="Felix" last="Feng">Felix Feng</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiation Oncology, University of California, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiation Oncology, University of California, San Francisco, CA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fizazi, Karim" sort="Fizazi, Karim" uniqKey="Fizazi K" first="Karim" last="Fizazi">Karim Fizazi</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Gustave Roussy, University of Paris Sud, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Medical Oncology, Gustave Roussy, University of Paris Sud, Paris</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Frydenberg, Mark" sort="Frydenberg, Mark" uniqKey="Frydenberg M" first="Mark" last="Frydenberg">Mark Frydenberg</name>
<affiliation>
<nlm:affiliation>Department of Surgery, Department of Anatomy and Developmental Biology, Faculty of Medicine, Nursing and Health Sciences, Monash University.</nlm:affiliation>
<wicri:noCountry code="subField">Monash University</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Gleave, Martin" sort="Gleave, Martin" uniqKey="Gleave M" first="Martin" last="Gleave">Martin Gleave</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Urology, Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Urology, Vancouver Prostate Centre, University of British Columbia, Vancouver, BC</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Halabi, Susan" sort="Halabi, Susan" uniqKey="Halabi S" first="Susan" last="Halabi">Susan Halabi</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Clinical trials and Statistics, Duke University, Durham, NC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Clinical trials and Statistics, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Heidenreich, Axel" sort="Heidenreich, Axel" uniqKey="Heidenreich A" first="Axel" last="Heidenreich">Axel Heidenreich</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Urology, University Hospital Köln, Köln, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Urology, University Hospital Köln, Köln</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Higano, Celestia S" sort="Higano, Celestia S" uniqKey="Higano C" first="Celestia S" last="Higano">Celestia S. Higano</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medicine, Division of Medical Oncology, University of Washington and Fred Hutchinson Cancer Research Center, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Medical Oncology, University of Washington and Fred Hutchinson Cancer Research Center, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="James, Nicolas" sort="James, Nicolas" uniqKey="James N" first="Nicolas" last="James">Nicolas James</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Clinical Oncology, Clinical Oncology Queen Elizabeth Hospital Birmingham and University of Birmingham, Birmingham, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Oncology, Clinical Oncology Queen Elizabeth Hospital Birmingham and University of Birmingham, Birmingham</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kantoff, Philip" sort="Kantoff, Philip" uniqKey="Kantoff P" first="Philip" last="Kantoff">Philip Kantoff</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kellokumpu Lehtinen, Pirkko Liisa" sort="Kellokumpu Lehtinen, Pirkko Liisa" uniqKey="Kellokumpu Lehtinen P" first="Pirkko-Liisa" last="Kellokumpu-Lehtinen">Pirkko-Liisa Kellokumpu-Lehtinen</name>
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<name sortKey="Khauli, Raja B" sort="Khauli, Raja B" uniqKey="Khauli R" first="Raja B" last="Khauli">Raja B. Khauli</name>
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<nlm:affiliation>Department of Urology, American University of Beirut Medical Center, Beirut, Lebanon.</nlm:affiliation>
<country xml:lang="fr">Liban</country>
<wicri:regionArea>Department of Urology, American University of Beirut Medical Center, Beirut</wicri:regionArea>
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<name sortKey="Kramer, Gero" sort="Kramer, Gero" uniqKey="Kramer G" first="Gero" last="Kramer">Gero Kramer</name>
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<nlm:affiliation>Department of Urology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Urology, Medical University of Vienna, Vienna</wicri:regionArea>
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<name sortKey="Logothetis, Chris" sort="Logothetis, Chris" uniqKey="Logothetis C" first="Chris" last="Logothetis">Chris Logothetis</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Genitourinary Medical Oncology, MD Anderson Cancer Centre, Houston, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genitourinary Medical Oncology, MD Anderson Cancer Centre, Houston, TX</wicri:regionArea>
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</author>
<author>
<name sortKey="Maluf, Fernando" sort="Maluf, Fernando" uniqKey="Maluf F" first="Fernando" last="Maluf">Fernando Maluf</name>
<affiliation>
<nlm:affiliation>Department of Medical Oncology Hospital Israelita Albert Einstein and Department of Medical Oncology Beneficência Portuguesa de São Paulo.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Medical Oncology Hospital Israelita Albert Einstein and Department of Medical Oncology Beneficência Portuguesa de São Paulo.</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Morgans, Alicia K" sort="Morgans, Alicia K" uniqKey="Morgans A" first="Alicia K" last="Morgans">Alicia K. Morgans</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology and Epidemiology, Vanderbilt University Medical Center, Division of Hematology/Oncology, Nashville, TN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology and Epidemiology, Vanderbilt University Medical Center, Division of Hematology/Oncology, Nashville, TN</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Morris, Michael J" sort="Morris, Michael J" uniqKey="Morris M" first="Michael J" last="Morris">Michael J. Morris</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mottet, Nicolas" sort="Mottet, Nicolas" uniqKey="Mottet N" first="Nicolas" last="Mottet">Nicolas Mottet</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Urology, University Hospital Nord St. Etienne, St. Etienne, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Urology, University Hospital Nord St. Etienne, St. Etienne</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Murthy, Vedang" sort="Murthy, Vedang" uniqKey="Murthy V" first="Vedang" last="Murthy">Vedang Murthy</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiation Oncology, Tata Memorial Centre, Mumbai, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Radiation Oncology, Tata Memorial Centre, Mumbai</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Oh, William" sort="Oh, William" uniqKey="Oh W" first="William" last="Oh">William Oh</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, The Tisch Cancer Institute, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, The Tisch Cancer Institute, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ost, Piet" sort="Ost, Piet" uniqKey="Ost P" first="Piet" last="Ost">Piet Ost</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Radiation Oncology, Ghent University Hospital, Ghent</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Padhani, Anwar R" sort="Padhani, Anwar R" uniqKey="Padhani A" first="Anwar R" last="Padhani">Anwar R. Padhani</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiology, Mount Vernon Cancer Centre and Institute of Cancer Research, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Radiology, Mount Vernon Cancer Centre and Institute of Cancer Research, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Parker, Chris" sort="Parker, Chris" uniqKey="Parker C" first="Chris" last="Parker">Chris Parker</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Clinical Oncology, Royal Marsden NHS Foundation Trust, Sutton, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Oncology, Royal Marsden NHS Foundation Trust, Sutton</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Pritchard, Colin C" sort="Pritchard, Colin C" uniqKey="Pritchard C" first="Colin C" last="Pritchard">Colin C. Pritchard</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Pathology, University of Washington, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, University of Washington, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Roach, Mack" sort="Roach, Mack" uniqKey="Roach M" first="Mack" last="Roach">Mack Roach</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiation Oncology, University of California, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiation Oncology, University of California, San Francisco, CA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rubin, Mark A" sort="Rubin, Mark A" uniqKey="Rubin M" first="Mark A" last="Rubin">Mark A. Rubin</name>
<affiliation>
<nlm:affiliation>Department of Pathology, University of Bern and the Inselspital, Bern (CH).</nlm:affiliation>
<wicri:noCountry code="subField">Bern (CH)</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Ryan, Charles" sort="Ryan, Charles" uniqKey="Ryan C" first="Charles" last="Ryan">Charles Ryan</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Clinical Medicine and Urology at the Helen Diller Family Comprehensive Cancer Center at the University of, California, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Clinical Medicine and Urology at the Helen Diller Family Comprehensive Cancer Center at the University of, California, San Francisco, CA</wicri:regionArea>
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<author>
<name sortKey="Saad, Fred" sort="Saad, Fred" uniqKey="Saad F" first="Fred" last="Saad">Fred Saad</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Urology, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Urology, Centre Hospitalier de l'Université de Montréal, Montreal, QC</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sartor, Oliver" sort="Sartor, Oliver" uniqKey="Sartor O" first="Oliver" last="Sartor">Oliver Sartor</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Tulane Cancer Center, New Orleans, LA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Tulane Cancer Center, New Orleans, LA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Scher, Howard" sort="Scher, Howard" uniqKey="Scher H" first="Howard" last="Scher">Howard Scher</name>
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<nlm:affiliation>Department of Medical Oncology, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Centre, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Centre, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sella, Avishay" sort="Sella, Avishay" uniqKey="Sella A" first="Avishay" last="Sella">Avishay Sella</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Department of Oncology, Assaf Harofeh Medical Centre, Tel-Aviv University, Sackler School of Medicine, Zerifin, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Medical Oncology, Department of Oncology, Assaf Harofeh Medical Centre, Tel-Aviv University, Sackler School of Medicine, Zerifin</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Shore, Neal" sort="Shore, Neal" uniqKey="Shore N" first="Neal" last="Shore">Neal Shore</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Urology, Carolina Urologic Research Center, Myrtle Beach, SC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Urology, Carolina Urologic Research Center, Myrtle Beach, SC</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Smith, Matthew" sort="Smith, Matthew" uniqKey="Smith M" first="Matthew" last="Smith">Matthew Smith</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Massachusetts General Hospital Cancer Centre, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Massachusetts General Hospital Cancer Centre, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Soule, Howard" sort="Soule, Howard" uniqKey="Soule H" first="Howard" last="Soule">Howard Soule</name>
<affiliation wicri:level="1">
<nlm:affiliation>Prostate Cancer Foundation, Santa Monica, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Prostate Cancer Foundation, Santa Monica, CA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sternberg, Cora N" sort="Sternberg, Cora N" uniqKey="Sternberg C" first="Cora N" last="Sternberg">Cora N. Sternberg</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, San Camillo Forlanini Hospital, Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical Oncology, San Camillo Forlanini Hospital, Rome</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Suzuki, Hiroyoshi" sort="Suzuki, Hiroyoshi" uniqKey="Suzuki H" first="Hiroyoshi" last="Suzuki">Hiroyoshi Suzuki</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Urology, Toho University Sakura Medical Center, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Urology, Toho University Sakura Medical Center</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sweeney, Christopher" sort="Sweeney, Christopher" uniqKey="Sweeney C" first="Christopher" last="Sweeney">Christopher Sweeney</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sydes, Matthew R" sort="Sydes, Matthew R" uniqKey="Sydes M" first="Matthew R" last="Sydes">Matthew R. Sydes</name>
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<nlm:affiliation>MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London</wicri:regionArea>
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<author>
<name sortKey="Tannock, Ian" sort="Tannock, Ian" uniqKey="Tannock I" first="Ian" last="Tannock">Ian Tannock</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Princess Margaret Cancer Centre and University of Toronto, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medical Oncology, Princess Margaret Cancer Centre and University of Toronto, Toronto, ON</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tombal, Bertrand" sort="Tombal, Bertrand" uniqKey="Tombal B" first="Bertrand" last="Tombal">Bertrand Tombal</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Urology, Cliniques Universitaires Saint Luc, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Urology, Cliniques Universitaires Saint Luc, Brussels</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Valdagni, Riccardo" sort="Valdagni, Riccardo" uniqKey="Valdagni R" first="Riccardo" last="Valdagni">Riccardo Valdagni</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Oncology and Haemato-oncology, Università degli Studi di Milano. Radiation Oncology 1, Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Oncology and Haemato-oncology, Università degli Studi di Milano. Radiation Oncology 1, Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wiegel, Thomas" sort="Wiegel, Thomas" uniqKey="Wiegel T" first="Thomas" last="Wiegel">Thomas Wiegel</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiation Oncology, Klinik für Strahlentherapie und Radioonkologie des Universitätsklinikum Ulm, Albert-Einstein-Allee, Ulm, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Radiation Oncology, Klinik für Strahlentherapie und Radioonkologie des Universitätsklinikum Ulm, Albert-Einstein-Allee, Ulm</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Omlin, Aurelius" sort="Omlin, Aurelius" uniqKey="Omlin A" first="Aurelius" last="Omlin">Aurelius Omlin</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Medical Oncology, Cantonal Hospital St. Gallen and University of Berne, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Medical Oncology, Cantonal Hospital St. Gallen and University of Berne</wicri:regionArea>
</affiliation>
</author>
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<series>
<title level="j">European urology</title>
<idno type="eISSN">1873-7560</idno>
<imprint>
<date when="2017" type="published">2017</date>
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<front>
<div type="abstract" xml:lang="en">In advanced prostate cancer (APC), successful drug development as well as advances in imaging and molecular characterisation have resulted in multiple areas where there is lack of evidence or low level of evidence. The Advanced Prostate Cancer Consensus Conference (APCCC) 2017 addressed some of these topics.</div>
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<PMID Version="1">28655541</PMID>
<DateCreated>
<Year>2017</Year>
<Month>06</Month>
<Day>28</Day>
</DateCreated>
<DateRevised>
<Year>2017</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1873-7560</ISSN>
<JournalIssue CitedMedium="Internet">
<PubDate>
<Year>2017</Year>
<Month>Jun</Month>
<Day>24</Day>
</PubDate>
</JournalIssue>
<Title>European urology</Title>
<ISOAbbreviation>Eur. Urol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">S0302-2838(17)30497-9</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.eururo.2017.06.002</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In advanced prostate cancer (APC), successful drug development as well as advances in imaging and molecular characterisation have resulted in multiple areas where there is lack of evidence or low level of evidence. The Advanced Prostate Cancer Consensus Conference (APCCC) 2017 addressed some of these topics.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To present the report of APCCC 2017.</AbstractText>
<AbstractText Label="DESIGN, SETTING, AND PARTICIPANTS" NlmCategory="METHODS">Ten important areas of controversy in APC management were identified: high-risk localised and locally advanced prostate cancer; "oligometastatic" prostate cancer; castration-naïve and castration-resistant prostate cancer; the role of imaging in APC; osteoclast-targeted therapy; molecular characterisation of blood and tissue; genetic counselling/testing; side effects of systemic treatment(s); global access to prostate cancer drugs. A panel of 60 international prostate cancer experts developed the program and the consensus questions.</AbstractText>
<AbstractText Label="OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS" NlmCategory="UNASSIGNED">The panel voted publicly but anonymously on 150 predefined questions, which have been developed following a modified Delphi process.</AbstractText>
<AbstractText Label="RESULTS AND LIMITATIONS" NlmCategory="CONCLUSIONS">Voting is based on panellist opinion, and thus is not based on a standard literature review or meta-analysis. The outcomes of the voting had varying degrees of support, as reflected in the wording of this article, as well as in the detailed voting results recorded in Supplementary data.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The presented expert voting results can be used for support in areas of management of men with APC where there is no high-level evidence, but individualised treatment decisions should as always be based on all of the data available, including disease extent and location, prior therapies regardless of type, host factors including comorbidities, as well as patient preferences, current and emerging evidence, and logistical and economic constraints. Inclusion of men with APC in clinical trials should be strongly encouraged. Importantly, APCCC 2017 again identified important areas in need of trials specifically designed to address them.</AbstractText>
<AbstractText Label="PATIENT SUMMARY" NlmCategory="UNASSIGNED">The second Advanced Prostate Cancer Consensus Conference APCCC 2017 did provide a forum for discussion and debates on current treatment options for men with advanced prostate cancer. The aim of the conference is to bring the expertise of world experts to care givers around the world who see less patients with prostate cancer. The conference concluded with a discussion and voting of the expert panel on predefined consensus questions, targeting areas of primary clinical relevance. The results of these expert opinion votes are embedded in the clinical context of current treatment of men with advanced prostate cancer and provide a practical guide to clinicians to assist in the discussions with men with prostate cancer as part of a shared and multidisciplinary decision-making process.</AbstractText>
<CopyrightInformation>Copyright © 2017 European Association of Urology. Published by Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
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<Author ValidYN="Y">
<LastName>Gillessen</LastName>
<ForeName>Silke</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>Department of Medical Oncology, Cantonal Hospital St. Gallen and University of Berne, Switzerland. Electronic address: silke.gillessen@kssg.ch.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Attard</LastName>
<ForeName>Gerhardt</ForeName>
<Initials>G</Initials>
<AffiliationInfo>
<Affiliation>Department of Medical Oncology, The Institute of Cancer Research/Royal Marsden, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Beer</LastName>
<ForeName>Tomasz M</ForeName>
<Initials>TM</Initials>
<AffiliationInfo>
<Affiliation>Oregon Health & Science University Knight Cancer Institute, OR, USA.</Affiliation>
</AffiliationInfo>
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<LastName>Beltran</LastName>
<ForeName>Himisha</ForeName>
<Initials>H</Initials>
<AffiliationInfo>
<Affiliation>Department of Medical Oncology, Weill Cornell Medicine, New York, NY, USA.</Affiliation>
</AffiliationInfo>
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<LastName>Bossi</LastName>
<ForeName>Alberto</ForeName>
<Initials>A</Initials>
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<Affiliation>Department of Radiation Oncology, Genito Urinary Oncology, Prostate Brachytherapy Unit, Goustave Roussy, Paris, France.</Affiliation>
</AffiliationInfo>
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<LastName>Bristow</LastName>
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<Initials>R</Initials>
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</AffiliationInfo>
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<LastName>Carver</LastName>
<ForeName>Brett</ForeName>
<Initials>B</Initials>
<AffiliationInfo>
<Affiliation>Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, New York, NY, USA.</Affiliation>
</AffiliationInfo>
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<LastName>Castellano</LastName>
<ForeName>Daniel</ForeName>
<Initials>D</Initials>
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<Affiliation>Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain.</Affiliation>
</AffiliationInfo>
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<LastName>Chung</LastName>
<ForeName>Byung Ha</ForeName>
<Initials>BH</Initials>
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<Affiliation>Department of Urology, Gangnam Severance Hospital, Yonsei University Health System, Seoul, Korea.</Affiliation>
</AffiliationInfo>
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<LastName>Clarke</LastName>
<ForeName>Noel</ForeName>
<Initials>N</Initials>
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<Affiliation>Department of Urology, The Christie and Salford Royal Hospitals, Manchester, UK.</Affiliation>
</AffiliationInfo>
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<LastName>Daugaard</LastName>
<ForeName>Gedske</ForeName>
<Initials>G</Initials>
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<Affiliation>Department of Medical Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.</Affiliation>
</AffiliationInfo>
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<LastName>Davis</LastName>
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<LastName>de Bono</LastName>
<ForeName>Johann</ForeName>
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<ForeName>Rodolfo Borges</ForeName>
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<Affiliation>Department of Urology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.</Affiliation>
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