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Treatment outcome in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study (ESOS).

Identifieur interne : 000A00 ( PubMed/Curation ); précédent : 000999; suivant : 000A01

Treatment outcome in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study (ESOS).

Auteurs : Ariane L. Herrick [Royaume-Uni] ; Xiaoyan Pan [Royaume-Uni] ; Sébastien Peytrignet [Royaume-Uni] ; Mark Lunt [Royaume-Uni] ; Roger Hesselstrand [Suède] ; Luc Mouthon [France] ; Alan Silman [Royaume-Uni] ; Edith Brown [Royaume-Uni] ; Lászl Czirják [Hongrie] ; Jörg H W. Distler [Allemagne] ; Oliver Distler [Suisse] ; Kim Fligelstone [Royaume-Uni] ; William J. Gregory [Royaume-Uni] ; Rachel Ochiel [Royaume-Uni] ; Madelon Vonk [Pays-Bas] ; Codrina Ancu A [Roumanie] ; Voon H. Ong [Royaume-Uni] ; Dominique Farge [France] ; Marie Hudson [Canada] ; Marco Matucci-Cerinic [Italie] ; Alexandra Balbir-Gurman [Israël] ; Yvind Midtvedt [Norvège] ; Alison C. Jordan [Royaume-Uni] ; Paresh Jobanputra [Royaume-Uni] ; Wendy Stevens [Australie] ; Pia Moinzadeh [Allemagne] ; Frances C. Hall [Royaume-Uni] ; Christian Agard [France] ; Marina E. Anderson [Royaume-Uni] ; Elisabeth Diot [France] ; Rajan Madhok [Royaume-Uni] ; Mohammed Akil [Royaume-Uni] ; Maya H. Buch [Royaume-Uni] ; Lorinda Chung [États-Unis] ; Nemanja Damjanov [Serbie] ; Harsha Gunawardena [Royaume-Uni] ; Peter Lanyon [Royaume-Uni] ; Yasmeen Ahmad [Royaume-Uni] ; Kuntal Chakravarty [Royaume-Uni] ; S Ren Jacobsen [Danemark] ; Alexander J. Macgregor [Royaume-Uni] ; Neil Mchugh [Royaume-Uni] ; Ulf Müller-Ladner [Allemagne] ; Gabriela Riemekasten [Allemagne] ; Michael Becker [Allemagne] ; Janet Roddy [Australie] ; Patricia E. Carreira [Espagne] ; Anne Laure Fauchais [France] ; Eric Hachulla [France] ; Jennifer Hamilton [Royaume-Uni] ; Murat Nanç [Turquie] ; John S. Mclaren [Royaume-Uni] ; Jacob M. Van Laar [Pays-Bas] ; Sanjay Pathare [Royaume-Uni] ; Susannah Proudman [Australie] ; Anna Rudin [Suède] ; Joanne Sahhar [Australie] ; Brigitte Coppere [France] ; Christine Serratrice [France] ; Tom Sheeran [Royaume-Uni] ; Douglas J. Veale [Irlande (pays)] ; Claire Grange [France] ; Georges-Selim Trad [France] ; Christopher P. Denton [Royaume-Uni]

Source :

Annals of the rheumatic diseases [ 1468-2060 ] ; 2017.

RBID : pubmed:28188239

Descripteurs français

KwdFr :
- Acide mycophénolique (usage thérapeutique), Adulte, Adulte d'âge moyen, Anticorps antinucléaires (immunologie), Autoanticorps (immunologie), Cyclophosphamide (usage thérapeutique), Europe, Femelle, Humains, Immunosuppresseurs (usage thérapeutique), Indice de gravité médicale, Intervention médicale précoce, Mâle, Méthotrexate (usage thérapeutique), Protéines nucléaires (immunologie), RNA polymerase III (immunologie), Résultat thérapeutique, Sclérodermie diffuse (immunologie), Sclérodermie diffuse (traitement médicamenteux), Taux de survie, Études de cohortes, Études prospectives.
MESH :
- immunologie : Anticorps antinucléaires, Autoanticorps, Protéines nucléaires, RNA polymerase III, Sclérodermie diffuse.
- traitement médicamenteux : Sclérodermie diffuse.
- usage thérapeutique : Acide mycophénolique, Cyclophosphamide, Immunosuppresseurs, Méthotrexate.
- Adulte, Adulte d'âge moyen, Europe, Femelle, Humains, Indice de gravité médicale, Intervention médicale précoce, Mâle, Résultat thérapeutique, Taux de survie, Études de cohortes, Études prospectives.

English descriptors

KwdEn :
- Adult, Antibodies, Antinuclear (immunology), Autoantibodies (immunology), Cohort Studies, Cyclophosphamide (therapeutic use), Early Medical Intervention, Europe, Female, Humans, Immunosuppressive Agents (therapeutic use), Male, Methotrexate (therapeutic use), Middle Aged, Mycophenolic Acid (therapeutic use), Nuclear Proteins (immunology), Prospective Studies, RNA Polymerase III (immunology), Scleroderma, Diffuse (drug therapy), Scleroderma, Diffuse (immunology), Severity of Illness Index, Survival Rate, Treatment Outcome.
MESH :
- chemical , immunology : Antibodies, Antinuclear, Autoantibodies, Nuclear Proteins, RNA Polymerase III.
- chemical , therapeutic use : Cyclophosphamide, Immunosuppressive Agents, Methotrexate, Mycophenolic Acid.
- drug therapy : Scleroderma, Diffuse.
- immunology : Scleroderma, Diffuse.
- Adult, Cohort Studies, Early Medical Intervention, Europe, Female, Humans, Male, Middle Aged, Prospective Studies, Severity of Illness Index, Survival Rate, Treatment Outcome.

Abstract

The rarity of early diffuse cutaneous systemic sclerosis (dcSSc) makes randomised controlled trials very difficult. We aimed to use an observational approach to compare effectiveness of currently used treatment approaches.

DOI: 10.1136/annrheumdis-2016-210503
PubMed: 28188239

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Le document en format XML

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<author><name sortKey="Herrick, Ariane L" sort="Herrick, Ariane L" uniqKey="Herrick A" first="Ariane L" last="Herrick">Ariane L. Herrick</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester</wicri:regionArea>
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<author><name sortKey="Pan, Xiaoyan" sort="Pan, Xiaoyan" uniqKey="Pan X" first="Xiaoyan" last="Pan">Xiaoyan Pan</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Musculoskeletal Research, The University of Manchester, Manchester Academic Health Science Centre, Manchester</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peytrignet, Sebastien" sort="Peytrignet, Sebastien" uniqKey="Peytrignet S" first="Sébastien" last="Peytrignet">Sébastien Peytrignet</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Musculoskeletal Research, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Musculoskeletal Research, The University of Manchester, Manchester Academic Health Science Centre, Manchester</wicri:regionArea>
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<author><name sortKey="Lunt, Mark" sort="Lunt, Mark" uniqKey="Lunt M" first="Mark" last="Lunt">Mark Lunt</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Musculoskeletal Research, The University of Manchester, Manchester Academic Health Science Centre, Manchester</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hesselstrand, Roger" sort="Hesselstrand, Roger" uniqKey="Hesselstrand R" first="Roger" last="Hesselstrand">Roger Hesselstrand</name>
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<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Rheumatology, Lund University, Lund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mouthon, Luc" sort="Mouthon, Luc" uniqKey="Mouthon L" first="Luc" last="Mouthon">Luc Mouthon</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Interne, Hôpital Cochin, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Université Paris Descartes, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris</wicri:regionArea>
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<author><name sortKey="Silman, Alan" sort="Silman, Alan" uniqKey="Silman A" first="Alan" last="Silman">Alan Silman</name>
<affiliation wicri:level="1"><nlm:affiliation>Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences,University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences,University of Oxford, Oxford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brown, Edith" sort="Brown, Edith" uniqKey="Brown E" first="Edith" last="Brown">Edith Brown</name>
<affiliation wicri:level="1"><nlm:affiliation>Member of Steering Committee, contact via Professor Herrick, The University of Manchester, Manchester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Member of Steering Committee, contact via Professor Herrick, The University of Manchester, Manchester</wicri:regionArea>
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</author>
<author><name sortKey="Czirjak, Laszl" sort="Czirjak, Laszl" uniqKey="Czirjak L" first="Lászl" last="Czirják">Lászl Czirják</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Medical Center, University of Pécs, Pecs, Hungary.</nlm:affiliation>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Department of Rheumatology and Immunology, Medical Center, University of Pécs, Pecs</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Distler, Jorg H W" sort="Distler, Jorg H W" uniqKey="Distler J" first="Jörg H W" last="Distler">Jörg H W. Distler</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen</wicri:regionArea>
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</author>
<author><name sortKey="Distler, Oliver" sort="Distler, Oliver" uniqKey="Distler O" first="Oliver" last="Distler">Oliver Distler</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, University of Zurich, Zurich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Rheumatology, University of Zurich, Zurich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fligelstone, Kim" sort="Fligelstone, Kim" uniqKey="Fligelstone K" first="Kim" last="Fligelstone">Kim Fligelstone</name>
<affiliation wicri:level="1"><nlm:affiliation>Royal Free London NHS Foundation Trust, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Royal Free London NHS Foundation Trust, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gregory, William J" sort="Gregory, William J" uniqKey="Gregory W" first="William J" last="Gregory">William J. Gregory</name>
<affiliation wicri:level="1"><nlm:affiliation>Rehabilitation Services, Salford Royal NHS Foundation Trust, Salford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rehabilitation Services, Salford Royal NHS Foundation Trust, Salford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ochiel, Rachel" sort="Ochiel, Rachel" uniqKey="Ochiel R" first="Rachel" last="Ochiel">Rachel Ochiel</name>
<affiliation wicri:level="1"><nlm:affiliation>Royal Free London NHS Foundation Trust, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Royal Free London NHS Foundation Trust, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vonk, Madelon" sort="Vonk, Madelon" uniqKey="Vonk M" first="Madelon" last="Vonk">Madelon Vonk</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of the Rheumatic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of the Rheumatic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ancu A, Codrina" sort="Ancu A, Codrina" uniqKey="Ancu A C" first="Codrina" last="Ancu A">Codrina Ancu A</name>
<affiliation wicri:level="1"><nlm:affiliation>Rheumatology 2 Department, "Grigore T. Popa" University of Medicine and Pharmacy, Clinical Rehabilitation Hospital, Iași, Romania.</nlm:affiliation>
<country xml:lang="fr">Roumanie</country>
<wicri:regionArea>Rheumatology 2 Department, "Grigore T. Popa" University of Medicine and Pharmacy, Clinical Rehabilitation Hospital, Iași</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ong, Voon H" sort="Ong, Voon H" uniqKey="Ong V" first="Voon H" last="Ong">Voon H. Ong</name>
<affiliation wicri:level="1"><nlm:affiliation>UCL Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Farge, Dominique" sort="Farge, Dominique" uniqKey="Farge D" first="Dominique" last="Farge">Dominique Farge</name>
<affiliation wicri:level="1"><nlm:affiliation>Unité Clinique de Médecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Hôpital Saint-Louis, AP-HP Assistance Publique des Hôpitaux de Paris, INSERM UMRS 1160, Paris Denis Diderot University, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité Clinique de Médecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Hôpital Saint-Louis, AP-HP Assistance Publique des Hôpitaux de Paris, INSERM UMRS 1160, Paris Denis Diderot University</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hudson, Marie" sort="Hudson, Marie" uniqKey="Hudson M" first="Marie" last="Hudson">Marie Hudson</name>
<affiliation wicri:level="1"><nlm:affiliation>Jewish General Hospital, Lady Davis Institute and McGill University, Montreal, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Jewish General Hospital, Lady Davis Institute and McGill University, Montreal</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Matucci Cerinic, Marco" sort="Matucci Cerinic, Marco" uniqKey="Matucci Cerinic M" first="Marco" last="Matucci-Cerinic">Marco Matucci-Cerinic</name>
<affiliation wicri:level="1"><nlm:affiliation>Department Experimental and Clinical Medicine, Division of Rheumatology AOUC, University of Florence, Florence, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department Experimental and Clinical Medicine, Division of Rheumatology AOUC, University of Florence, Florence</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Balbir Gurman, Alexandra" sort="Balbir Gurman, Alexandra" uniqKey="Balbir Gurman A" first="Alexandra" last="Balbir-Gurman">Alexandra Balbir-Gurman</name>
<affiliation wicri:level="1"><nlm:affiliation>Shine Rheumatology Unit, Rambam Heath Care Campus; Rappaport Faculty of Medicine, Haifa, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Shine Rheumatology Unit, Rambam Heath Care Campus; Rappaport Faculty of Medicine, Haifa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Midtvedt,  Yvind" sort="Midtvedt,  Yvind" uniqKey="Midtvedt  " first=" Yvind" last="Midtvedt"> Yvind Midtvedt</name>
<affiliation wicri:level="1"><nlm:affiliation>Rheumatology Unit, Oslo University Hospital Rikshospitalet, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Rheumatology Unit, Oslo University Hospital Rikshospitalet, Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jordan, Alison C" sort="Jordan, Alison C" uniqKey="Jordan A" first="Alison C" last="Jordan">Alison C. Jordan</name>
<affiliation wicri:level="1"><nlm:affiliation>Queen Elizabeth Hospital Birmingham, UHB Foundation Trust, Birmingham, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Queen Elizabeth Hospital Birmingham, UHB Foundation Trust, Birmingham</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jobanputra, Paresh" sort="Jobanputra, Paresh" uniqKey="Jobanputra P" first="Paresh" last="Jobanputra">Paresh Jobanputra</name>
<affiliation wicri:level="1"><nlm:affiliation>Queen Elizabeth Hospital Birmingham, UHB Foundation Trust, Birmingham, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Queen Elizabeth Hospital Birmingham, UHB Foundation Trust, Birmingham</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stevens, Wendy" sort="Stevens, Wendy" uniqKey="Stevens W" first="Wendy" last="Stevens">Wendy Stevens</name>
<affiliation wicri:level="1"><nlm:affiliation>St Vincent's Hospital, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>St Vincent's Hospital, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moinzadeh, Pia" sort="Moinzadeh, Pia" uniqKey="Moinzadeh P" first="Pia" last="Moinzadeh">Pia Moinzadeh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department for Dermatology, University of Cologne Kerpenerstr. 62, Köln, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department for Dermatology, University of Cologne Kerpenerstr. 62, Köln</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hall, Frances C" sort="Hall, Frances C" uniqKey="Hall F" first="Frances C" last="Hall">Frances C. Hall</name>
<affiliation wicri:level="1"><nlm:affiliation>Cambridge University NHS Hospital Foundation Trust, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cambridge University NHS Hospital Foundation Trust, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Agard, Christian" sort="Agard, Christian" uniqKey="Agard C" first="Christian" last="Agard">Christian Agard</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Hôtel-Dieu Hospital, University of Nantes, Nantes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Internal Medicine, Hôtel-Dieu Hospital, University of Nantes, Nantes</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Anderson, Marina E" sort="Anderson, Marina E" uniqKey="Anderson M" first="Marina E" last="Anderson">Marina E. Anderson</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Liverpool, Aintree University Hospital, Liverpool, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Liverpool, Aintree University Hospital, Liverpool</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Diot, Elisabeth" sort="Diot, Elisabeth" uniqKey="Diot E" first="Elisabeth" last="Diot">Elisabeth Diot</name>
<affiliation wicri:level="1"><nlm:affiliation>Service de Médecine Interne, Hôpital Bretonneau Tours Cedex, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Interne, Hôpital Bretonneau Tours Cedex</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Madhok, Rajan" sort="Madhok, Rajan" uniqKey="Madhok R" first="Rajan" last="Madhok">Rajan Madhok</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Akil, Mohammed" sort="Akil, Mohammed" uniqKey="Akil M" first="Mohammed" last="Akil">Mohammed Akil</name>
<affiliation wicri:level="1"><nlm:affiliation>Sheffield Teaching Hospitals, Sheffield, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sheffield Teaching Hospitals, Sheffield</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Buch, Maya H" sort="Buch, Maya H" uniqKey="Buch M" first="Maya H" last="Buch">Maya H. Buch</name>
<affiliation wicri:level="1"><nlm:affiliation>Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chung, Lorinda" sort="Chung, Lorinda" uniqKey="Chung L" first="Lorinda" last="Chung">Lorinda Chung</name>
<affiliation wicri:level="1"><nlm:affiliation>Stanford University, Stanford, California, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University, Stanford, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Damjanov, Nemanja" sort="Damjanov, Nemanja" uniqKey="Damjanov N" first="Nemanja" last="Damjanov">Nemanja Damjanov</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Belgrade School of Medicine, Institute of Rheumatology, Belgrade, Serbia.</nlm:affiliation>
<country xml:lang="fr">Serbie</country>
<wicri:regionArea>University of Belgrade School of Medicine, Institute of Rheumatology, Belgrade</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gunawardena, Harsha" sort="Gunawardena, Harsha" uniqKey="Gunawardena H" first="Harsha" last="Gunawardena">Harsha Gunawardena</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical and Academic Rheumatology, North Bristol NHS Trust, Bristol, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical and Academic Rheumatology, North Bristol NHS Trust, Bristol</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lanyon, Peter" sort="Lanyon, Peter" uniqKey="Lanyon P" first="Peter" last="Lanyon">Peter Lanyon</name>
<affiliation wicri:level="1"><nlm:affiliation>Nottingham University Hospitals NHS Trust, and Nottingham NHS Treatment Centre, Nottingham, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Nottingham University Hospitals NHS Trust, and Nottingham NHS Treatment Centre, Nottingham</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ahmad, Yasmeen" sort="Ahmad, Yasmeen" uniqKey="Ahmad Y" first="Yasmeen" last="Ahmad">Yasmeen Ahmad</name>
<affiliation wicri:level="1"><nlm:affiliation>Peter Maddison Rheumatology Centre, Llandudno, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Peter Maddison Rheumatology Centre, Llandudno</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chakravarty, Kuntal" sort="Chakravarty, Kuntal" uniqKey="Chakravarty K" first="Kuntal" last="Chakravarty">Kuntal Chakravarty</name>
<affiliation wicri:level="1"><nlm:affiliation>Queens Hospital, Romford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Queens Hospital, Romford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jacobsen, S Ren" sort="Jacobsen, S Ren" uniqKey="Jacobsen S" first="S Ren" last="Jacobsen">S Ren Jacobsen</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Copenhagen, Copenhagen Lupus and Vasculitis Clinic, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>University of Copenhagen, Copenhagen Lupus and Vasculitis Clinic, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Macgregor, Alexander J" sort="Macgregor, Alexander J" uniqKey="Macgregor A" first="Alexander J" last="Macgregor">Alexander J. Macgregor</name>
<affiliation wicri:level="1"><nlm:affiliation>Norwich Medical School, University of East Anglia, Norwich, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Norwich Medical School, University of East Anglia, Norwich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mchugh, Neil" sort="Mchugh, Neil" uniqKey="Mchugh N" first="Neil" last="Mchugh">Neil Mchugh</name>
<affiliation wicri:level="1"><nlm:affiliation>Royal National Hospital for Rheumatic Diseases, Bath, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Royal National Hospital for Rheumatic Diseases, Bath</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Muller Ladner, Ulf" sort="Muller Ladner, Ulf" uniqKey="Muller Ladner U" first="Ulf" last="Müller-Ladner">Ulf Müller-Ladner</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Clinical Immunology, Justus-Liebig University Giessen, Bad Nauheim, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Rheumatology and Clinical Immunology, Justus-Liebig University Giessen, Bad Nauheim</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Riemekasten, Gabriela" sort="Riemekasten, Gabriela" uniqKey="Riemekasten G" first="Gabriela" last="Riemekasten">Gabriela Riemekasten</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, University of Lübeck, Lübeck, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Rheumatology, University of Lübeck, Lübeck</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Becker, Michael" sort="Becker, Michael" uniqKey="Becker M" first="Michael" last="Becker">Michael Becker</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Clinical Immunology, University Hospital Charité Berlin, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Rheumatology and Clinical Immunology, University Hospital Charité Berlin, Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Roddy, Janet" sort="Roddy, Janet" uniqKey="Roddy J" first="Janet" last="Roddy">Janet Roddy</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Royal Perth Hospital, Perth, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Rheumatology, Royal Perth Hospital, Perth</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carreira, Patricia E" sort="Carreira, Patricia E" uniqKey="Carreira P" first="Patricia E" last="Carreira">Patricia E. Carreira</name>
<affiliation wicri:level="1"><nlm:affiliation>Servicio de Reumatologia. Hospital Universitario 12 de Octubre, Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Servicio de Reumatologia. Hospital Universitario 12 de Octubre, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fauchais, Anne Laure" sort="Fauchais, Anne Laure" uniqKey="Fauchais A" first="Anne Laure" last="Fauchais">Anne Laure Fauchais</name>
<affiliation wicri:level="1"><nlm:affiliation>Internal Medicine Unit, Limoges University Hospital, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Internal Medicine Unit, Limoges University Hospital</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hachulla, Eric" sort="Hachulla, Eric" uniqKey="Hachulla E" first="Eric" last="Hachulla">Eric Hachulla</name>
<affiliation wicri:level="1"><nlm:affiliation>Département de Médecine Interne et Immunologie Clinique, Centre National de Référence Maladies Systémiques etAuto-immunes Rares, Université de Lille, Inserm, U995, FHU Immune-Mediated Inflammatory Diseases and Targeted Therapies, Lille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département de Médecine Interne et Immunologie Clinique, Centre National de Référence Maladies Systémiques etAuto-immunes Rares, Université de Lille, Inserm, U995, FHU Immune-Mediated Inflammatory Diseases and Targeted Therapies, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hamilton, Jennifer" sort="Hamilton, Jennifer" uniqKey="Hamilton J" first="Jennifer" last="Hamilton">Jennifer Hamilton</name>
<affiliation wicri:level="1"><nlm:affiliation>Gateshead Hospitals Foundation Trust, Gateshead, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Gateshead Hospitals Foundation Trust, Gateshead</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey=" Nanc, Murat" sort=" Nanc, Murat" uniqKey=" Nanc M" first="Murat" last=" Nanç">Murat  Nanç</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul, Turkey.</nlm:affiliation>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mclaren, John S" sort="Mclaren, John S" uniqKey="Mclaren J" first="John S" last="Mclaren">John S. Mclaren</name>
<affiliation wicri:level="1"><nlm:affiliation>Fife Rheumatic Diseases Unit, Whyteman's Brae Hospital, Kirkcaldy, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Fife Rheumatic Diseases Unit, Whyteman's Brae Hospital, Kirkcaldy</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Laar, Jacob M" sort="Van Laar, Jacob M" uniqKey="Van Laar J" first="Jacob M" last="Van Laar">Jacob M. Van Laar</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pathare, Sanjay" sort="Pathare, Sanjay" uniqKey="Pathare S" first="Sanjay" last="Pathare">Sanjay Pathare</name>
<affiliation wicri:level="1"><nlm:affiliation>James Cook University Hospital, Middlesbrough, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>James Cook University Hospital, Middlesbrough</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Proudman, Susannah" sort="Proudman, Susannah" uniqKey="Proudman S" first="Susannah" last="Proudman">Susannah Proudman</name>
<affiliation wicri:level="2"><nlm:affiliation>Rheumatology Unit, Royal Adelaide Hospital, and Discipline of Medicine, University of Adelaide, Adelaide, South Australia.</nlm:affiliation>
<country>Australie</country>
<placeName><region type="state">Australie-Méridionale</region>
</placeName>
<wicri:cityArea>Rheumatology Unit, Royal Adelaide Hospital, and Discipline of Medicine, University of Adelaide, Adelaide</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rudin, Anna" sort="Rudin, Anna" uniqKey="Rudin A" first="Anna" last="Rudin">Anna Rudin</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Gothenburg University, Gothenburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sahhar, Joanne" sort="Sahhar, Joanne" uniqKey="Sahhar J" first="Joanne" last="Sahhar">Joanne Sahhar</name>
<affiliation wicri:level="1"><nlm:affiliation>Monash Centre for Inflammatory Diseases, Monash University, Clayton, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Monash Centre for Inflammatory Diseases, Monash University, Clayton, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Coppere, Brigitte" sort="Coppere, Brigitte" uniqKey="Coppere B" first="Brigitte" last="Coppere">Brigitte Coppere</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Hôpital Edouard Herriot, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Internal Medicine, Hôpital Edouard Herriot, Lyon</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Serratrice, Christine" sort="Serratrice, Christine" uniqKey="Serratrice C" first="Christine" last="Serratrice">Christine Serratrice</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Foundation Hospital Saint Joseph, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Internal Medicine, Foundation Hospital Saint Joseph, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sheeran, Tom" sort="Sheeran, Tom" uniqKey="Sheeran T" first="Tom" last="Sheeran">Tom Sheeran</name>
<affiliation wicri:level="1"><nlm:affiliation>Cannock Chase Hospital, Cannock, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cannock Chase Hospital, Cannock</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Veale, Douglas J" sort="Veale, Douglas J" uniqKey="Veale D" first="Douglas J" last="Veale">Douglas J. Veale</name>
<affiliation wicri:level="1"><nlm:affiliation>St Vincent's University Hospital, Dublin, Ireland.</nlm:affiliation>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>St Vincent's University Hospital, Dublin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Grange, Claire" sort="Grange, Claire" uniqKey="Grange C" first="Claire" last="Grange">Claire Grange</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Centre Hospitalier Lyon Sud, Pierre Benite, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Internal Medicine, Centre Hospitalier Lyon Sud, Pierre Benite</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Trad, Georges Selim" sort="Trad, Georges Selim" uniqKey="Trad G" first="Georges-Selim" last="Trad">Georges-Selim Trad</name>
<affiliation wicri:level="1"><nlm:affiliation>Internal Medecine, Ambroise Paré Hospital, Boulogne Billancourt, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Internal Medecine, Ambroise Paré Hospital, Boulogne Billancourt</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Denton, Christopher P" sort="Denton, Christopher P" uniqKey="Denton C" first="Christopher P" last="Denton">Christopher P. Denton</name>
<affiliation wicri:level="1"><nlm:affiliation>UCL Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28188239</idno>
<idno type="pmid">28188239</idno>
<idno type="doi">10.1136/annrheumdis-2016-210503</idno>
<idno type="wicri:Area/PubMed/Corpus">000A03</idno>
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<idno type="wicri:Area/PubMed/Curation">000A00</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A00</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Treatment outcome in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study (ESOS).</title>
<author><name sortKey="Herrick, Ariane L" sort="Herrick, Ariane L" uniqKey="Herrick A" first="Ariane L" last="Herrick">Ariane L. Herrick</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pan, Xiaoyan" sort="Pan, Xiaoyan" uniqKey="Pan X" first="Xiaoyan" last="Pan">Xiaoyan Pan</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Musculoskeletal Research, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Musculoskeletal Research, The University of Manchester, Manchester Academic Health Science Centre, Manchester</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peytrignet, Sebastien" sort="Peytrignet, Sebastien" uniqKey="Peytrignet S" first="Sébastien" last="Peytrignet">Sébastien Peytrignet</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Musculoskeletal Research, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Musculoskeletal Research, The University of Manchester, Manchester Academic Health Science Centre, Manchester</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lunt, Mark" sort="Lunt, Mark" uniqKey="Lunt M" first="Mark" last="Lunt">Mark Lunt</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Musculoskeletal Research, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Musculoskeletal Research, The University of Manchester, Manchester Academic Health Science Centre, Manchester</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hesselstrand, Roger" sort="Hesselstrand, Roger" uniqKey="Hesselstrand R" first="Roger" last="Hesselstrand">Roger Hesselstrand</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Lund University, Lund, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Rheumatology, Lund University, Lund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mouthon, Luc" sort="Mouthon, Luc" uniqKey="Mouthon L" first="Luc" last="Mouthon">Luc Mouthon</name>
<affiliation wicri:level="1"><nlm:affiliation>Service de Médecine Interne, Hôpital Cochin, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Université Paris Descartes, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Interne, Hôpital Cochin, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Université Paris Descartes, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Silman, Alan" sort="Silman, Alan" uniqKey="Silman A" first="Alan" last="Silman">Alan Silman</name>
<affiliation wicri:level="1"><nlm:affiliation>Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences,University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences,University of Oxford, Oxford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brown, Edith" sort="Brown, Edith" uniqKey="Brown E" first="Edith" last="Brown">Edith Brown</name>
<affiliation wicri:level="1"><nlm:affiliation>Member of Steering Committee, contact via Professor Herrick, The University of Manchester, Manchester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Member of Steering Committee, contact via Professor Herrick, The University of Manchester, Manchester</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Czirjak, Laszl" sort="Czirjak, Laszl" uniqKey="Czirjak L" first="Lászl" last="Czirják">Lászl Czirják</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Immunology, Medical Center, University of Pécs, Pecs, Hungary.</nlm:affiliation>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Department of Rheumatology and Immunology, Medical Center, University of Pécs, Pecs</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Distler, Jorg H W" sort="Distler, Jorg H W" uniqKey="Distler J" first="Jörg H W" last="Distler">Jörg H W. Distler</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Distler, Oliver" sort="Distler, Oliver" uniqKey="Distler O" first="Oliver" last="Distler">Oliver Distler</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, University of Zurich, Zurich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Rheumatology, University of Zurich, Zurich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fligelstone, Kim" sort="Fligelstone, Kim" uniqKey="Fligelstone K" first="Kim" last="Fligelstone">Kim Fligelstone</name>
<affiliation wicri:level="1"><nlm:affiliation>Royal Free London NHS Foundation Trust, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Royal Free London NHS Foundation Trust, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gregory, William J" sort="Gregory, William J" uniqKey="Gregory W" first="William J" last="Gregory">William J. Gregory</name>
<affiliation wicri:level="1"><nlm:affiliation>Rehabilitation Services, Salford Royal NHS Foundation Trust, Salford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rehabilitation Services, Salford Royal NHS Foundation Trust, Salford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ochiel, Rachel" sort="Ochiel, Rachel" uniqKey="Ochiel R" first="Rachel" last="Ochiel">Rachel Ochiel</name>
<affiliation wicri:level="1"><nlm:affiliation>Royal Free London NHS Foundation Trust, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Royal Free London NHS Foundation Trust, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vonk, Madelon" sort="Vonk, Madelon" uniqKey="Vonk M" first="Madelon" last="Vonk">Madelon Vonk</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of the Rheumatic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of the Rheumatic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ancu A, Codrina" sort="Ancu A, Codrina" uniqKey="Ancu A C" first="Codrina" last="Ancu A">Codrina Ancu A</name>
<affiliation wicri:level="1"><nlm:affiliation>Rheumatology 2 Department, "Grigore T. Popa" University of Medicine and Pharmacy, Clinical Rehabilitation Hospital, Iași, Romania.</nlm:affiliation>
<country xml:lang="fr">Roumanie</country>
<wicri:regionArea>Rheumatology 2 Department, "Grigore T. Popa" University of Medicine and Pharmacy, Clinical Rehabilitation Hospital, Iași</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ong, Voon H" sort="Ong, Voon H" uniqKey="Ong V" first="Voon H" last="Ong">Voon H. Ong</name>
<affiliation wicri:level="1"><nlm:affiliation>UCL Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Farge, Dominique" sort="Farge, Dominique" uniqKey="Farge D" first="Dominique" last="Farge">Dominique Farge</name>
<affiliation wicri:level="1"><nlm:affiliation>Unité Clinique de Médecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Hôpital Saint-Louis, AP-HP Assistance Publique des Hôpitaux de Paris, INSERM UMRS 1160, Paris Denis Diderot University, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité Clinique de Médecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Hôpital Saint-Louis, AP-HP Assistance Publique des Hôpitaux de Paris, INSERM UMRS 1160, Paris Denis Diderot University</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hudson, Marie" sort="Hudson, Marie" uniqKey="Hudson M" first="Marie" last="Hudson">Marie Hudson</name>
<affiliation wicri:level="1"><nlm:affiliation>Jewish General Hospital, Lady Davis Institute and McGill University, Montreal, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Jewish General Hospital, Lady Davis Institute and McGill University, Montreal</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Matucci Cerinic, Marco" sort="Matucci Cerinic, Marco" uniqKey="Matucci Cerinic M" first="Marco" last="Matucci-Cerinic">Marco Matucci-Cerinic</name>
<affiliation wicri:level="1"><nlm:affiliation>Department Experimental and Clinical Medicine, Division of Rheumatology AOUC, University of Florence, Florence, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department Experimental and Clinical Medicine, Division of Rheumatology AOUC, University of Florence, Florence</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Balbir Gurman, Alexandra" sort="Balbir Gurman, Alexandra" uniqKey="Balbir Gurman A" first="Alexandra" last="Balbir-Gurman">Alexandra Balbir-Gurman</name>
<affiliation wicri:level="1"><nlm:affiliation>Shine Rheumatology Unit, Rambam Heath Care Campus; Rappaport Faculty of Medicine, Haifa, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Shine Rheumatology Unit, Rambam Heath Care Campus; Rappaport Faculty of Medicine, Haifa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Midtvedt,  Yvind" sort="Midtvedt,  Yvind" uniqKey="Midtvedt  " first=" Yvind" last="Midtvedt"> Yvind Midtvedt</name>
<affiliation wicri:level="1"><nlm:affiliation>Rheumatology Unit, Oslo University Hospital Rikshospitalet, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Rheumatology Unit, Oslo University Hospital Rikshospitalet, Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jordan, Alison C" sort="Jordan, Alison C" uniqKey="Jordan A" first="Alison C" last="Jordan">Alison C. Jordan</name>
<affiliation wicri:level="1"><nlm:affiliation>Queen Elizabeth Hospital Birmingham, UHB Foundation Trust, Birmingham, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Queen Elizabeth Hospital Birmingham, UHB Foundation Trust, Birmingham</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jobanputra, Paresh" sort="Jobanputra, Paresh" uniqKey="Jobanputra P" first="Paresh" last="Jobanputra">Paresh Jobanputra</name>
<affiliation wicri:level="1"><nlm:affiliation>Queen Elizabeth Hospital Birmingham, UHB Foundation Trust, Birmingham, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Queen Elizabeth Hospital Birmingham, UHB Foundation Trust, Birmingham</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stevens, Wendy" sort="Stevens, Wendy" uniqKey="Stevens W" first="Wendy" last="Stevens">Wendy Stevens</name>
<affiliation wicri:level="1"><nlm:affiliation>St Vincent's Hospital, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>St Vincent's Hospital, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moinzadeh, Pia" sort="Moinzadeh, Pia" uniqKey="Moinzadeh P" first="Pia" last="Moinzadeh">Pia Moinzadeh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department for Dermatology, University of Cologne Kerpenerstr. 62, Köln, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Hall, Frances C" sort="Hall, Frances C" uniqKey="Hall F" first="Frances C" last="Hall">Frances C. Hall</name>
<affiliation wicri:level="1"><nlm:affiliation>Cambridge University NHS Hospital Foundation Trust, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cambridge University NHS Hospital Foundation Trust, Cambridge</wicri:regionArea>
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<author><name sortKey="Agard, Christian" sort="Agard, Christian" uniqKey="Agard C" first="Christian" last="Agard">Christian Agard</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Hôtel-Dieu Hospital, University of Nantes, Nantes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Internal Medicine, Hôtel-Dieu Hospital, University of Nantes, Nantes</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Anderson, Marina E" sort="Anderson, Marina E" uniqKey="Anderson M" first="Marina E" last="Anderson">Marina E. Anderson</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Liverpool, Aintree University Hospital, Liverpool, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Liverpool, Aintree University Hospital, Liverpool</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Diot, Elisabeth" sort="Diot, Elisabeth" uniqKey="Diot E" first="Elisabeth" last="Diot">Elisabeth Diot</name>
<affiliation wicri:level="1"><nlm:affiliation>Service de Médecine Interne, Hôpital Bretonneau Tours Cedex, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Interne, Hôpital Bretonneau Tours Cedex</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Madhok, Rajan" sort="Madhok, Rajan" uniqKey="Madhok R" first="Rajan" last="Madhok">Rajan Madhok</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Akil, Mohammed" sort="Akil, Mohammed" uniqKey="Akil M" first="Mohammed" last="Akil">Mohammed Akil</name>
<affiliation wicri:level="1"><nlm:affiliation>Sheffield Teaching Hospitals, Sheffield, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sheffield Teaching Hospitals, Sheffield</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Buch, Maya H" sort="Buch, Maya H" uniqKey="Buch M" first="Maya H" last="Buch">Maya H. Buch</name>
<affiliation wicri:level="1"><nlm:affiliation>Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chung, Lorinda" sort="Chung, Lorinda" uniqKey="Chung L" first="Lorinda" last="Chung">Lorinda Chung</name>
<affiliation wicri:level="1"><nlm:affiliation>Stanford University, Stanford, California, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University, Stanford, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Damjanov, Nemanja" sort="Damjanov, Nemanja" uniqKey="Damjanov N" first="Nemanja" last="Damjanov">Nemanja Damjanov</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Belgrade School of Medicine, Institute of Rheumatology, Belgrade, Serbia.</nlm:affiliation>
<country xml:lang="fr">Serbie</country>
<wicri:regionArea>University of Belgrade School of Medicine, Institute of Rheumatology, Belgrade</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gunawardena, Harsha" sort="Gunawardena, Harsha" uniqKey="Gunawardena H" first="Harsha" last="Gunawardena">Harsha Gunawardena</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical and Academic Rheumatology, North Bristol NHS Trust, Bristol, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical and Academic Rheumatology, North Bristol NHS Trust, Bristol</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lanyon, Peter" sort="Lanyon, Peter" uniqKey="Lanyon P" first="Peter" last="Lanyon">Peter Lanyon</name>
<affiliation wicri:level="1"><nlm:affiliation>Nottingham University Hospitals NHS Trust, and Nottingham NHS Treatment Centre, Nottingham, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Nottingham University Hospitals NHS Trust, and Nottingham NHS Treatment Centre, Nottingham</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ahmad, Yasmeen" sort="Ahmad, Yasmeen" uniqKey="Ahmad Y" first="Yasmeen" last="Ahmad">Yasmeen Ahmad</name>
<affiliation wicri:level="1"><nlm:affiliation>Peter Maddison Rheumatology Centre, Llandudno, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Peter Maddison Rheumatology Centre, Llandudno</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chakravarty, Kuntal" sort="Chakravarty, Kuntal" uniqKey="Chakravarty K" first="Kuntal" last="Chakravarty">Kuntal Chakravarty</name>
<affiliation wicri:level="1"><nlm:affiliation>Queens Hospital, Romford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Queens Hospital, Romford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jacobsen, S Ren" sort="Jacobsen, S Ren" uniqKey="Jacobsen S" first="S Ren" last="Jacobsen">S Ren Jacobsen</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Copenhagen, Copenhagen Lupus and Vasculitis Clinic, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>University of Copenhagen, Copenhagen Lupus and Vasculitis Clinic, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Macgregor, Alexander J" sort="Macgregor, Alexander J" uniqKey="Macgregor A" first="Alexander J" last="Macgregor">Alexander J. Macgregor</name>
<affiliation wicri:level="1"><nlm:affiliation>Norwich Medical School, University of East Anglia, Norwich, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Norwich Medical School, University of East Anglia, Norwich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mchugh, Neil" sort="Mchugh, Neil" uniqKey="Mchugh N" first="Neil" last="Mchugh">Neil Mchugh</name>
<affiliation wicri:level="1"><nlm:affiliation>Royal National Hospital for Rheumatic Diseases, Bath, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Royal National Hospital for Rheumatic Diseases, Bath</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Muller Ladner, Ulf" sort="Muller Ladner, Ulf" uniqKey="Muller Ladner U" first="Ulf" last="Müller-Ladner">Ulf Müller-Ladner</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Clinical Immunology, Justus-Liebig University Giessen, Bad Nauheim, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Rheumatology and Clinical Immunology, Justus-Liebig University Giessen, Bad Nauheim</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Riemekasten, Gabriela" sort="Riemekasten, Gabriela" uniqKey="Riemekasten G" first="Gabriela" last="Riemekasten">Gabriela Riemekasten</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, University of Lübeck, Lübeck, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Rheumatology, University of Lübeck, Lübeck</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Becker, Michael" sort="Becker, Michael" uniqKey="Becker M" first="Michael" last="Becker">Michael Becker</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Clinical Immunology, University Hospital Charité Berlin, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Rheumatology and Clinical Immunology, University Hospital Charité Berlin, Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Roddy, Janet" sort="Roddy, Janet" uniqKey="Roddy J" first="Janet" last="Roddy">Janet Roddy</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Royal Perth Hospital, Perth, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Rheumatology, Royal Perth Hospital, Perth</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carreira, Patricia E" sort="Carreira, Patricia E" uniqKey="Carreira P" first="Patricia E" last="Carreira">Patricia E. Carreira</name>
<affiliation wicri:level="1"><nlm:affiliation>Servicio de Reumatologia. Hospital Universitario 12 de Octubre, Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Servicio de Reumatologia. Hospital Universitario 12 de Octubre, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fauchais, Anne Laure" sort="Fauchais, Anne Laure" uniqKey="Fauchais A" first="Anne Laure" last="Fauchais">Anne Laure Fauchais</name>
<affiliation wicri:level="1"><nlm:affiliation>Internal Medicine Unit, Limoges University Hospital, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Internal Medicine Unit, Limoges University Hospital</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hachulla, Eric" sort="Hachulla, Eric" uniqKey="Hachulla E" first="Eric" last="Hachulla">Eric Hachulla</name>
<affiliation wicri:level="1"><nlm:affiliation>Département de Médecine Interne et Immunologie Clinique, Centre National de Référence Maladies Systémiques etAuto-immunes Rares, Université de Lille, Inserm, U995, FHU Immune-Mediated Inflammatory Diseases and Targeted Therapies, Lille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département de Médecine Interne et Immunologie Clinique, Centre National de Référence Maladies Systémiques etAuto-immunes Rares, Université de Lille, Inserm, U995, FHU Immune-Mediated Inflammatory Diseases and Targeted Therapies, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hamilton, Jennifer" sort="Hamilton, Jennifer" uniqKey="Hamilton J" first="Jennifer" last="Hamilton">Jennifer Hamilton</name>
<affiliation wicri:level="1"><nlm:affiliation>Gateshead Hospitals Foundation Trust, Gateshead, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Gateshead Hospitals Foundation Trust, Gateshead</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey=" Nanc, Murat" sort=" Nanc, Murat" uniqKey=" Nanc M" first="Murat" last=" Nanç">Murat  Nanç</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul, Turkey.</nlm:affiliation>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mclaren, John S" sort="Mclaren, John S" uniqKey="Mclaren J" first="John S" last="Mclaren">John S. Mclaren</name>
<affiliation wicri:level="1"><nlm:affiliation>Fife Rheumatic Diseases Unit, Whyteman's Brae Hospital, Kirkcaldy, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Fife Rheumatic Diseases Unit, Whyteman's Brae Hospital, Kirkcaldy</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Laar, Jacob M" sort="Van Laar, Jacob M" uniqKey="Van Laar J" first="Jacob M" last="Van Laar">Jacob M. Van Laar</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pathare, Sanjay" sort="Pathare, Sanjay" uniqKey="Pathare S" first="Sanjay" last="Pathare">Sanjay Pathare</name>
<affiliation wicri:level="1"><nlm:affiliation>James Cook University Hospital, Middlesbrough, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>James Cook University Hospital, Middlesbrough</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Proudman, Susannah" sort="Proudman, Susannah" uniqKey="Proudman S" first="Susannah" last="Proudman">Susannah Proudman</name>
<affiliation wicri:level="2"><nlm:affiliation>Rheumatology Unit, Royal Adelaide Hospital, and Discipline of Medicine, University of Adelaide, Adelaide, South Australia.</nlm:affiliation>
<country>Australie</country>
<placeName><region type="state">Australie-Méridionale</region>
</placeName>
<wicri:cityArea>Rheumatology Unit, Royal Adelaide Hospital, and Discipline of Medicine, University of Adelaide, Adelaide</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rudin, Anna" sort="Rudin, Anna" uniqKey="Rudin A" first="Anna" last="Rudin">Anna Rudin</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Gothenburg University, Gothenburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sahhar, Joanne" sort="Sahhar, Joanne" uniqKey="Sahhar J" first="Joanne" last="Sahhar">Joanne Sahhar</name>
<affiliation wicri:level="1"><nlm:affiliation>Monash Centre for Inflammatory Diseases, Monash University, Clayton, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Monash Centre for Inflammatory Diseases, Monash University, Clayton, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Coppere, Brigitte" sort="Coppere, Brigitte" uniqKey="Coppere B" first="Brigitte" last="Coppere">Brigitte Coppere</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Hôpital Edouard Herriot, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Internal Medicine, Hôpital Edouard Herriot, Lyon</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Serratrice, Christine" sort="Serratrice, Christine" uniqKey="Serratrice C" first="Christine" last="Serratrice">Christine Serratrice</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Foundation Hospital Saint Joseph, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Internal Medicine, Foundation Hospital Saint Joseph, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sheeran, Tom" sort="Sheeran, Tom" uniqKey="Sheeran T" first="Tom" last="Sheeran">Tom Sheeran</name>
<affiliation wicri:level="1"><nlm:affiliation>Cannock Chase Hospital, Cannock, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cannock Chase Hospital, Cannock</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Veale, Douglas J" sort="Veale, Douglas J" uniqKey="Veale D" first="Douglas J" last="Veale">Douglas J. Veale</name>
<affiliation wicri:level="1"><nlm:affiliation>St Vincent's University Hospital, Dublin, Ireland.</nlm:affiliation>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>St Vincent's University Hospital, Dublin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Grange, Claire" sort="Grange, Claire" uniqKey="Grange C" first="Claire" last="Grange">Claire Grange</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Centre Hospitalier Lyon Sud, Pierre Benite, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Internal Medicine, Centre Hospitalier Lyon Sud, Pierre Benite</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Trad, Georges Selim" sort="Trad, Georges Selim" uniqKey="Trad G" first="Georges-Selim" last="Trad">Georges-Selim Trad</name>
<affiliation wicri:level="1"><nlm:affiliation>Internal Medecine, Ambroise Paré Hospital, Boulogne Billancourt, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Internal Medecine, Ambroise Paré Hospital, Boulogne Billancourt</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Denton, Christopher P" sort="Denton, Christopher P" uniqKey="Denton C" first="Christopher P" last="Denton">Christopher P. Denton</name>
<affiliation wicri:level="1"><nlm:affiliation>UCL Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London</wicri:regionArea>
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<series><title level="j">Annals of the rheumatic diseases</title>
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<term>Cohort Studies</term>
<term>Cyclophosphamide (therapeutic use)</term>
<term>Early Medical Intervention</term>
<term>Europe</term>
<term>Female</term>
<term>Humans</term>
<term>Immunosuppressive Agents (therapeutic use)</term>
<term>Male</term>
<term>Methotrexate (therapeutic use)</term>
<term>Middle Aged</term>
<term>Mycophenolic Acid (therapeutic use)</term>
<term>Nuclear Proteins (immunology)</term>
<term>Prospective Studies</term>
<term>RNA Polymerase III (immunology)</term>
<term>Scleroderma, Diffuse (drug therapy)</term>
<term>Scleroderma, Diffuse (immunology)</term>
<term>Severity of Illness Index</term>
<term>Survival Rate</term>
<term>Treatment Outcome</term>
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<term>Sclérodermie diffuse (traitement médicamenteux)</term>
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<term>Études de cohortes</term>
<term>Études prospectives</term>
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<term>Protéines nucléaires</term>
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<term>Sclérodermie diffuse</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">The rarity of early diffuse cutaneous systemic sclerosis (dcSSc) makes randomised controlled trials very difficult. We aimed to use an observational approach to compare effectiveness of currently used treatment approaches.</div>
</front>
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<DateCreated><Year>2017</Year>
<Month>02</Month>
<Day>11</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>08</Month>
<Day>21</Day>
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<DateRevised><Year>2017</Year>
<Month>08</Month>
<Day>21</Day>
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<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-2060</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>76</Volume>
<Issue>7</Issue>
<PubDate><Year>2017</Year>
<Month>Jul</Month>
</PubDate>
</JournalIssue>
<Title>Annals of the rheumatic diseases</Title>
<ISOAbbreviation>Ann. Rheum. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>Treatment outcome in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study (ESOS).</ArticleTitle>
<Pagination><MedlinePgn>1207-1218</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1136/annrheumdis-2016-210503</ELocationID>
<Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The rarity of early diffuse cutaneous systemic sclerosis (dcSSc) makes randomised controlled trials very difficult. We aimed to use an observational approach to compare effectiveness of currently used treatment approaches.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">This was a prospective, observational cohort study of early dcSSc (within three years of onset of skin thickening). Clinicians selected one of four protocols for each patient: methotrexate, mycophenolate mofetil (MMF), cyclophosphamide or 'no immunosuppressant'. Patients were assessed three-monthly for up to 24 months. The primary outcome was the change in modified Rodnan skin score (mRSS). Confounding by indication at baseline was accounted for using inverse probability of treatment (IPT) weights. As a secondary outcome, an IPT-weighted Cox model was used to test for differences in survival.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Of 326 patients recruited from 50 centres, 65 were prescribed methotrexate, 118 MMF, 87 cyclophosphamide and 56 no immunosuppressant. 276 (84.7%) patients completed 12 and 234 (71.7%) 24 months follow-up (or reached last visit date). There were statistically significant reductions in mRSS at 12 months in all groups: -4.0 (-5.2 to -2.7) units for methotrexate, -4.1 (-5.3 to -2.9) for MMF, -3.3 (-4.9 to -1.7) for cyclophosphamide and -2.2 (-4.0 to -0.3) for no immunosuppressant (p value for between-group differences=0.346). There were no statistically significant differences in survival between protocols before (p=0.389) or after weighting (p=0.440), but survival was poorest in the no immunosuppressant group (84.0%) at 24 months.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These findings may support using immunosuppressants for early dcSSc but suggest that overall benefit is modest over 12 months and that better treatments are needed.</AbstractText>
<AbstractText Label="TRIAL REGISTRATION NUMBER" NlmCategory="BACKGROUND">NCT02339441.</AbstractText>
<CopyrightInformation>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.</CopyrightInformation>
</Abstract>
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<Initials>AL</Initials>
<AffiliationInfo><Affiliation>Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.</Affiliation>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D064888">Observational Study</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>02</Month>
<Day>10</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Ann Rheum Dis</MedlineTA>
<NlmUniqueID>0372355</NlmUniqueID>
<ISSNLinking>0003-4967</ISSNLinking>
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<CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2006 Jun 22;354(25):2655-66</RefSource>
<PMID Version="1">16790698</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2007 Feb 15;57(1):94-102</RefSource>
<PMID Version="1">17266096</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2000 Nov;43(11):2445-54</RefSource>
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</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2001 Jun;44(6):1351-8</RefSource>
<PMID Version="1">11407694</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Health Qual Life Outcomes. 2003 Dec 16;1:79</RefSource>
<PMID Version="1">14678568</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Rheumatol. 2010 Jan;37(1):116-24</RefSource>
<PMID Version="1">19955050</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2012 Oct;64(10):3420-9</RefSource>
<PMID Version="1">22328195</PMID>
</CommentsCorrections>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D000974" MajorTopicYN="N">Antibodies, Antinuclear</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001323" MajorTopicYN="N">Autoantibodies</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003520" MajorTopicYN="N">Cyclophosphamide</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D061345" MajorTopicYN="N">Early Medical Intervention</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005060" MajorTopicYN="N">Europe</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007166" MajorTopicYN="N">Immunosuppressive Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008727" MajorTopicYN="N">Methotrexate</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009173" MajorTopicYN="N">Mycophenolic Acid</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009687" MajorTopicYN="N">Nuclear Proteins</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012320" MajorTopicYN="N">RNA Polymerase III</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045743" MajorTopicYN="N">Scleroderma, Diffuse</DescriptorName>
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<CoiStatement>Competing interests: ALH has done consultancy work for Actelion, served on a Data Safety Monitoring Board for Apricus, received research funding and speaker's fees from Actelion, and speaker's fees from GSK. JHWD has consultancy relationships and/or has received research funding from Actelion, BMS, Celgene, Bayer Pharma, Boehringer Ingelheim, JB Therapeutics, Sanofi-Aventis, Novartis, UCB, GSK, Array Biopharma, Active Biotech, Galapagos, Inventiva, Medac, Pfizer, Anamar and RuiYi and is stock owner of 4D Science GmbH. OD has received consultancy fees from 4D Science, Actelion, Active Biotech, Bayer, Biogenidec, BMS, Boehringer Ingelheim, EpiPharm, Ergonex, espeRare Foundation, Genentech/Roche, GSK, Inventiva, Lilly, Medac, Medimmune, Pharmacyclics, Pfizer, Serodapharm, and Sinoxa and received research grants from Actelion, Bayer, Boehringer Ingelheim, Ergonex, Pfizer and Sanofi, and has a patent mir-29 for the treatment of systemic sclerosis licenced. WG has received teaching fees from Pfizer. FH has received research funding from Actelion. MEA has undertaken advisory board work and received honoraria from Actelion, and received speaker's fees from Bristol-Myers Squibb. LC has done advisory board work for Gilead and served Data Safety Monitoring Boards for Cytori and Reata. HG has done consultancy work and received honoraria from Actelion. UM-L is funded in part bu EUSTAR/EULAR. JMvL has received honoraria from Eli Lilly, Pfizer, Roche, MSD and BMS. AR receives funding from AstraZeneca. CPD has done consultancy for GSK, Actelion, Bayer, Inventiva and Merck-Serono, received research grant funding from GSK, Actelion, CSL Behring and Inventiva, received speaker's fees from Bayer and given trial advice to Merck-Serono.</CoiStatement>
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<PubMedPubDate PubStatus="revised"><Year>2016</Year>
<Month>11</Month>
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<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
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Treatment outcome in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study (ESOS).

Treatment outcome in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study (ESOS).

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