The growing world of small heat shock proteins: from structure to functions.
Identifieur interne : 000998 ( PubMed/Curation ); précédent : 000997; suivant : 000999The growing world of small heat shock proteins: from structure to functions.
Auteurs : Serena Carra [Italie] ; Simon Alberti [Allemagne] ; Patrick A. Arrigo [France] ; Justin L. Benesch [Royaume-Uni] ; Ivor J. Benjamin [États-Unis] ; Wilbert Boelens [Pays-Bas] ; Britta Bartelt-Kirbach [Allemagne] ; Bianca J J M. Brundel [Pays-Bas] ; Johannes Buchner [Allemagne] ; Bernd Bukau [Allemagne] ; John A. Carver [Australie] ; Heath Ecroyd [Australie] ; Cecilia Emanuelsson [Suède] ; Stephanie Finet [France] ; Nikola Golenhofen [Allemagne] ; Pierre Goloubinoff [Suisse] ; Nikolai Gusev [Russie] ; Martin Haslbeck [Allemagne] ; Lawrence E. Hightower [États-Unis] ; Harm H. Kampinga [Pays-Bas] ; Rachel E. Klevit [États-Unis] ; Krzysztof Liberek [Pologne] ; Hassane S. Mchaourab [États-Unis] ; Kathryn A. Mcmenimen [États-Unis] ; Angelo Poletti [Italie] ; Roy Quinlan [Royaume-Uni] ; Sergei V. Strelkov [Belgique] ; Melinda E. Toth [Hongrie] ; Elizabeth Vierling [États-Unis] ; Robert M. Tanguay [Canada]Source :
- Cell stress & chaperones [ 1466-1268 ] ; 2017.
Abstract
Small heat shock proteins (sHSPs) are present in all kingdoms of life and play fundamental roles in cell biology. sHSPs are key components of the cellular protein quality control system, acting as the first line of defense against conditions that affect protein homeostasis and proteome stability, from bacteria to plants to humans. sHSPs have the ability to bind to a large subset of substrates and to maintain them in a state competent for refolding or clearance with the assistance of the HSP70 machinery. sHSPs participate in a number of biological processes, from the cell cycle, to cell differentiation, from adaptation to stressful conditions, to apoptosis, and, even, to the transformation of a cell into a malignant state. As a consequence, sHSP malfunction has been implicated in abnormal placental development and preterm deliveries, in the prognosis of several types of cancer, and in the development of neurological diseases. Moreover, mutations in the genes encoding several mammalian sHSPs result in neurological, muscular, or cardiac age-related diseases in humans. Loss of protein homeostasis due to protein aggregation is typical of many age-related neurodegenerative and neuromuscular diseases. In light of the role of sHSPs in the clearance of un/misfolded aggregation-prone substrates, pharmacological modulation of sHSP expression or function and rescue of defective sHSPs represent possible routes to alleviate or cure protein conformation diseases. Here, we report the latest news and views on sHSPs discussed by many of the world's experts in the sHSP field during a dedicated workshop organized in Italy (Bertinoro, CEUB, October 12-15, 2016).
DOI: 10.1007/s12192-017-0787-8
PubMed: 28364346
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Brundel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Buchner, Johannes" sort="Buchner, Johannes" uniqKey="Buchner J" first="Johannes" last="Buchner">Johannes Buchner</name><affiliation wicri:level="1"><nlm:affiliation>Technische Universitat Munchen, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Technische Universitat Munchen, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Bukau, Bernd" sort="Bukau, Bernd" uniqKey="Bukau B" first="Bernd" last="Bukau">Bernd Bukau</name><affiliation wicri:level="1"><nlm:affiliation>Center for Molecular Biology of the University of Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Molecular Biology of the University of Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Carver, John A" sort="Carver, John A" uniqKey="Carver J" first="John A" last="Carver">John A. Carver</name><affiliation wicri:level="1"><nlm:affiliation>The Research School of Chemistry, The Australian National University, Acton, ACT, 2601, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Research School of Chemistry, The Australian National University, Acton, ACT, 2601</wicri:regionArea></affiliation></author><author><name sortKey="Ecroyd, Heath" sort="Ecroyd, Heath" uniqKey="Ecroyd H" first="Heath" last="Ecroyd">Heath Ecroyd</name><affiliation wicri:level="1"><nlm:affiliation>Illawara Health and Medical Research Institute, School of Biological Sciences, University of Wollongong, Wollongong, NSW, 2522, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Illawara Health and Medical Research Institute, School of Biological Sciences, University of Wollongong, Wollongong, NSW, 2522</wicri:regionArea></affiliation></author><author><name sortKey="Emanuelsson, Cecilia" sort="Emanuelsson, Cecilia" uniqKey="Emanuelsson C" first="Cecilia" last="Emanuelsson">Cecilia Emanuelsson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University, 221 00, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University, 221 00, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Finet, Stephanie" sort="Finet, Stephanie" uniqKey="Finet S" first="Stephanie" last="Finet">Stephanie Finet</name><affiliation wicri:level="1"><nlm:affiliation>IMPMC UMR7590, CNRS, UPMC Paris 6, 4 place Jussieu, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IMPMC UMR7590, CNRS, UPMC Paris 6, 4 place Jussieu, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Golenhofen, Nikola" sort="Golenhofen, Nikola" uniqKey="Golenhofen N" first="Nikola" last="Golenhofen">Nikola Golenhofen</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Anatomy and Cell Biology, University of Ulm, 89081, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Anatomy and Cell Biology, University of Ulm, 89081, Ulm</wicri:regionArea></affiliation></author><author><name sortKey="Goloubinoff, Pierre" sort="Goloubinoff, Pierre" uniqKey="Goloubinoff P" first="Pierre" last="Goloubinoff">Pierre Goloubinoff</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Molecular Biology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Plant Molecular Biology, Faculty of Biology and Medicine, University of Lausanne, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Gusev, Nikolai" sort="Gusev, Nikolai" uniqKey="Gusev N" first="Nikolai" last="Gusev">Nikolai Gusev</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, School of Biology, Moscow State University, Moscow, 119991, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Biochemistry, School of Biology, Moscow State University, Moscow, 119991</wicri:regionArea></affiliation></author><author><name sortKey="Haslbeck, Martin" sort="Haslbeck, Martin" uniqKey="Haslbeck M" first="Martin" last="Haslbeck">Martin Haslbeck</name><affiliation wicri:level="1"><nlm:affiliation>Technische Universitat Munchen, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Technische Universitat Munchen, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Hightower, Lawrence E" sort="Hightower, Lawrence E" uniqKey="Hightower L" first="Lawrence E" last="Hightower">Lawrence E. Hightower</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular & Cell Biology, University of Connecticut, 91 North Eagleville Road, Storrs, CT, 06269-3125, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular & Cell Biology, University of Connecticut, 91 North Eagleville Road, Storrs, CT, 06269-3125</wicri:regionArea></affiliation></author><author><name sortKey="Kampinga, Harm H" sort="Kampinga, Harm H" uniqKey="Kampinga H" first="Harm H" last="Kampinga">Harm H. Kampinga</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cell Biology, University Medical Center Groningen, University of Groningen, 9713 GZ, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cell Biology, University Medical Center Groningen, University of Groningen, 9713 GZ, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Klevit, Rachel E" sort="Klevit, Rachel E" uniqKey="Klevit R" first="Rachel E" last="Klevit">Rachel E. Klevit</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Washington, Seattle, WA, 98195</wicri:regionArea></affiliation></author><author><name sortKey="Liberek, Krzysztof" sort="Liberek, Krzysztof" uniqKey="Liberek K" first="Krzysztof" last="Liberek">Krzysztof Liberek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Cellular Biology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and the Medical University of Gdańsk, Gdańsk, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Molecular and Cellular Biology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and the Medical University of Gdańsk, Gdańsk</wicri:regionArea></affiliation></author><author><name sortKey="Mchaourab, Hassane S" sort="Mchaourab, Hassane S" uniqKey="Mchaourab H" first="Hassane S" last="Mchaourab">Hassane S. Mchaourab</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232</wicri:regionArea></affiliation></author><author><name sortKey="Mcmenimen, Kathryn A" sort="Mcmenimen, Kathryn A" uniqKey="Mcmenimen K" first="Kathryn A" last="Mcmenimen">Kathryn A. Mcmenimen</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Pathology, Biological Chemistry, and Medicinal Chemistry and the Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Pathology, Biological Chemistry, and Medicinal Chemistry and the Life Sciences Institute, University of Michigan, Ann Arbor, MI</wicri:regionArea></affiliation></author><author><name sortKey="Poletti, Angelo" sort="Poletti, Angelo" uniqKey="Poletti A" first="Angelo" last="Poletti">Angelo Poletti</name><affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Quinlan, Roy" sort="Quinlan, Roy" uniqKey="Quinlan R" first="Roy" last="Quinlan">Roy Quinlan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biosciences and the Biophysical Sciences Institute, University of Durham, Durham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biosciences and the Biophysical Sciences Institute, University of Durham, Durham</wicri:regionArea></affiliation></author><author><name sortKey="Strelkov, Sergei V" sort="Strelkov, Sergei V" uniqKey="Strelkov S" first="Sergei V" last="Strelkov">Sergei V. Strelkov</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory for Biocrystallography, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory for Biocrystallography, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Toth, Melinda E" sort="Toth, Melinda E" uniqKey="Toth M" first="Melinda E" last="Toth">Melinda E. Toth</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Animal Genetics and Molecular Neurobiology, Institute of Biochemistry, Biological Research Centre, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Laboratory of Animal Genetics and Molecular Neurobiology, Institute of Biochemistry, Biological Research Centre, Szeged</wicri:regionArea></affiliation></author><author><name sortKey="Vierling, Elizabeth" sort="Vierling, Elizabeth" uniqKey="Vierling E" first="Elizabeth" last="Vierling">Elizabeth Vierling</name><affiliation wicri:level="1"><nlm:affiliation>Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA, 01003, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA, 01003</wicri:regionArea></affiliation></author><author><name sortKey="Tanguay, Robert M" sort="Tanguay, Robert M" uniqKey="Tanguay R" first="Robert M" last="Tanguay">Robert M. Tanguay</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Cell & Developmental Genetics, IBIS, and Department of Molecular Biology, Medical Biochemistry and Pathology, Medical School, Université Laval, Québec (Qc), G1V 0A6, Canada. Robert.tanguay@fmed.ulaval.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory of Cell & Developmental Genetics, IBIS, and Department of Molecular Biology, Medical Biochemistry and Pathology, Medical School, Université Laval, Québec (Qc), G1V 0A6</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28364346</idno><idno type="pmid">28364346</idno><idno type="doi">10.1007/s12192-017-0787-8</idno><idno type="wicri:Area/PubMed/Corpus">000A01</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A01</idno><idno type="wicri:Area/PubMed/Curation">000998</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000998</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The growing world of small heat shock proteins: from structure to functions.</title><author><name sortKey="Carra, Serena" sort="Carra, Serena" uniqKey="Carra S" first="Serena" last="Carra">Serena Carra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical, Metabolic and Neural Sciences, and Centre for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, via G. Campi 287, 41125, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedical, Metabolic and Neural Sciences, and Centre for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, via G. Campi 287, 41125, Modena</wicri:regionArea></affiliation></author><author><name sortKey="Alberti, Simon" sort="Alberti, Simon" uniqKey="Alberti S" first="Simon" last="Alberti">Simon Alberti</name><affiliation wicri:level="1"><nlm:affiliation>Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Molecular Cell Biology and Genetics, Dresden</wicri:regionArea></affiliation></author><author><name sortKey="Arrigo, Patrick A" sort="Arrigo, Patrick A" uniqKey="Arrigo P" first="Patrick A" last="Arrigo">Patrick A. Arrigo</name><affiliation wicri:level="1"><nlm:affiliation>Université de Lyon, 69622, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lyon, 69622, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Benesch, Justin L" sort="Benesch, Justin L" uniqKey="Benesch J" first="Justin L" last="Benesch">Justin L. Benesch</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, University of Oxford, Oxford, OX1 3TA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Chemistry, University of Oxford, Oxford, OX1 3TA</wicri:regionArea></affiliation></author><author><name sortKey="Benjamin, Ivor J" sort="Benjamin, Ivor J" uniqKey="Benjamin I" first="Ivor J" last="Benjamin">Ivor J. Benjamin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Utah, Salt Lake City, UT, 84112-5650, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Utah, Salt Lake City, UT, 84112-5650</wicri:regionArea></affiliation></author><author><name sortKey="Boelens, Wilbert" sort="Boelens, Wilbert" uniqKey="Boelens W" first="Wilbert" last="Boelens">Wilbert Boelens</name><affiliation wicri:level="1"><nlm:affiliation>Biomolecular Chemistry, 284, Radboud University, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Biomolecular Chemistry, 284, Radboud University, PO Box 9101, 6500 HB, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Bartelt Kirbach, Britta" sort="Bartelt Kirbach, Britta" uniqKey="Bartelt Kirbach B" first="Britta" last="Bartelt-Kirbach">Britta Bartelt-Kirbach</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Anatomy and Cell Biology, University of Ulm, 89081, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Anatomy and Cell Biology, University of Ulm, 89081, Ulm</wicri:regionArea></affiliation></author><author><name sortKey="Brundel, Bianca J J M" sort="Brundel, Bianca J J M" uniqKey="Brundel B" first="Bianca J J M" last="Brundel">Bianca J J M. Brundel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Buchner, Johannes" sort="Buchner, Johannes" uniqKey="Buchner J" first="Johannes" last="Buchner">Johannes Buchner</name><affiliation wicri:level="1"><nlm:affiliation>Technische Universitat Munchen, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Technische Universitat Munchen, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Bukau, Bernd" sort="Bukau, Bernd" uniqKey="Bukau B" first="Bernd" last="Bukau">Bernd Bukau</name><affiliation wicri:level="1"><nlm:affiliation>Center for Molecular Biology of the University of Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Molecular Biology of the University of Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Carver, John A" sort="Carver, John A" uniqKey="Carver J" first="John A" last="Carver">John A. Carver</name><affiliation wicri:level="1"><nlm:affiliation>The Research School of Chemistry, The Australian National University, Acton, ACT, 2601, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Research School of Chemistry, The Australian National University, Acton, ACT, 2601</wicri:regionArea></affiliation></author><author><name sortKey="Ecroyd, Heath" sort="Ecroyd, Heath" uniqKey="Ecroyd H" first="Heath" last="Ecroyd">Heath Ecroyd</name><affiliation wicri:level="1"><nlm:affiliation>Illawara Health and Medical Research Institute, School of Biological Sciences, University of Wollongong, Wollongong, NSW, 2522, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Illawara Health and Medical Research Institute, School of Biological Sciences, University of Wollongong, Wollongong, NSW, 2522</wicri:regionArea></affiliation></author><author><name sortKey="Emanuelsson, Cecilia" sort="Emanuelsson, Cecilia" uniqKey="Emanuelsson C" first="Cecilia" last="Emanuelsson">Cecilia Emanuelsson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University, 221 00, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University, 221 00, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Finet, Stephanie" sort="Finet, Stephanie" uniqKey="Finet S" first="Stephanie" last="Finet">Stephanie Finet</name><affiliation wicri:level="1"><nlm:affiliation>IMPMC UMR7590, CNRS, UPMC Paris 6, 4 place Jussieu, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IMPMC UMR7590, CNRS, UPMC Paris 6, 4 place Jussieu, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Golenhofen, Nikola" sort="Golenhofen, Nikola" uniqKey="Golenhofen N" first="Nikola" last="Golenhofen">Nikola Golenhofen</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Anatomy and Cell Biology, University of Ulm, 89081, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Anatomy and Cell Biology, University of Ulm, 89081, Ulm</wicri:regionArea></affiliation></author><author><name sortKey="Goloubinoff, Pierre" sort="Goloubinoff, Pierre" uniqKey="Goloubinoff P" first="Pierre" last="Goloubinoff">Pierre Goloubinoff</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Molecular Biology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Plant Molecular Biology, Faculty of Biology and Medicine, University of Lausanne, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Gusev, Nikolai" sort="Gusev, Nikolai" uniqKey="Gusev N" first="Nikolai" last="Gusev">Nikolai Gusev</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, School of Biology, Moscow State University, Moscow, 119991, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Biochemistry, School of Biology, Moscow State University, Moscow, 119991</wicri:regionArea></affiliation></author><author><name sortKey="Haslbeck, Martin" sort="Haslbeck, Martin" uniqKey="Haslbeck M" first="Martin" last="Haslbeck">Martin Haslbeck</name><affiliation wicri:level="1"><nlm:affiliation>Technische Universitat Munchen, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Technische Universitat Munchen, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Hightower, Lawrence E" sort="Hightower, Lawrence E" uniqKey="Hightower L" first="Lawrence E" last="Hightower">Lawrence E. Hightower</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular & Cell Biology, University of Connecticut, 91 North Eagleville Road, Storrs, CT, 06269-3125, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular & Cell Biology, University of Connecticut, 91 North Eagleville Road, Storrs, CT, 06269-3125</wicri:regionArea></affiliation></author><author><name sortKey="Kampinga, Harm H" sort="Kampinga, Harm H" uniqKey="Kampinga H" first="Harm H" last="Kampinga">Harm H. Kampinga</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cell Biology, University Medical Center Groningen, University of Groningen, 9713 GZ, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cell Biology, University Medical Center Groningen, University of Groningen, 9713 GZ, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Klevit, Rachel E" sort="Klevit, Rachel E" uniqKey="Klevit R" first="Rachel E" last="Klevit">Rachel E. Klevit</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Washington, Seattle, WA, 98195</wicri:regionArea></affiliation></author><author><name sortKey="Liberek, Krzysztof" sort="Liberek, Krzysztof" uniqKey="Liberek K" first="Krzysztof" last="Liberek">Krzysztof Liberek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Cellular Biology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and the Medical University of Gdańsk, Gdańsk, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Molecular and Cellular Biology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and the Medical University of Gdańsk, Gdańsk</wicri:regionArea></affiliation></author><author><name sortKey="Mchaourab, Hassane S" sort="Mchaourab, Hassane S" uniqKey="Mchaourab H" first="Hassane S" last="Mchaourab">Hassane S. Mchaourab</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232</wicri:regionArea></affiliation></author><author><name sortKey="Mcmenimen, Kathryn A" sort="Mcmenimen, Kathryn A" uniqKey="Mcmenimen K" first="Kathryn A" last="Mcmenimen">Kathryn A. Mcmenimen</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Pathology, Biological Chemistry, and Medicinal Chemistry and the Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Pathology, Biological Chemistry, and Medicinal Chemistry and the Life Sciences Institute, University of Michigan, Ann Arbor, MI</wicri:regionArea></affiliation></author><author><name sortKey="Poletti, Angelo" sort="Poletti, Angelo" uniqKey="Poletti A" first="Angelo" last="Poletti">Angelo Poletti</name><affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Quinlan, Roy" sort="Quinlan, Roy" uniqKey="Quinlan R" first="Roy" last="Quinlan">Roy Quinlan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biosciences and the Biophysical Sciences Institute, University of Durham, Durham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biosciences and the Biophysical Sciences Institute, University of Durham, Durham</wicri:regionArea></affiliation></author><author><name sortKey="Strelkov, Sergei V" sort="Strelkov, Sergei V" uniqKey="Strelkov S" first="Sergei V" last="Strelkov">Sergei V. Strelkov</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory for Biocrystallography, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory for Biocrystallography, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Toth, Melinda E" sort="Toth, Melinda E" uniqKey="Toth M" first="Melinda E" last="Toth">Melinda E. Toth</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Animal Genetics and Molecular Neurobiology, Institute of Biochemistry, Biological Research Centre, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Laboratory of Animal Genetics and Molecular Neurobiology, Institute of Biochemistry, Biological Research Centre, Szeged</wicri:regionArea></affiliation></author><author><name sortKey="Vierling, Elizabeth" sort="Vierling, Elizabeth" uniqKey="Vierling E" first="Elizabeth" last="Vierling">Elizabeth Vierling</name><affiliation wicri:level="1"><nlm:affiliation>Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA, 01003, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA, 01003</wicri:regionArea></affiliation></author><author><name sortKey="Tanguay, Robert M" sort="Tanguay, Robert M" uniqKey="Tanguay R" first="Robert M" last="Tanguay">Robert M. Tanguay</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Cell & Developmental Genetics, IBIS, and Department of Molecular Biology, Medical Biochemistry and Pathology, Medical School, Université Laval, Québec (Qc), G1V 0A6, Canada. Robert.tanguay@fmed.ulaval.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory of Cell & Developmental Genetics, IBIS, and Department of Molecular Biology, Medical Biochemistry and Pathology, Medical School, Université Laval, Québec (Qc), G1V 0A6</wicri:regionArea></affiliation></author></analytic><series><title level="j">Cell stress & chaperones</title><idno type="eISSN">1466-1268</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Small heat shock proteins (sHSPs) are present in all kingdoms of life and play fundamental roles in cell biology. sHSPs are key components of the cellular protein quality control system, acting as the first line of defense against conditions that affect protein homeostasis and proteome stability, from bacteria to plants to humans. sHSPs have the ability to bind to a large subset of substrates and to maintain them in a state competent for refolding or clearance with the assistance of the HSP70 machinery. sHSPs participate in a number of biological processes, from the cell cycle, to cell differentiation, from adaptation to stressful conditions, to apoptosis, and, even, to the transformation of a cell into a malignant state. As a consequence, sHSP malfunction has been implicated in abnormal placental development and preterm deliveries, in the prognosis of several types of cancer, and in the development of neurological diseases. Moreover, mutations in the genes encoding several mammalian sHSPs result in neurological, muscular, or cardiac age-related diseases in humans. Loss of protein homeostasis due to protein aggregation is typical of many age-related neurodegenerative and neuromuscular diseases. In light of the role of sHSPs in the clearance of un/misfolded aggregation-prone substrates, pharmacological modulation of sHSP expression or function and rescue of defective sHSPs represent possible routes to alleviate or cure protein conformation diseases. Here, we report the latest news and views on sHSPs discussed by many of the world's experts in the sHSP field during a dedicated workshop organized in Italy (Bertinoro, CEUB, October 12-15, 2016).</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28364346</PMID><DateCreated><Year>2017</Year><Month>04</Month><Day>01</Day></DateCreated><DateRevised><Year>2017</Year><Month>07</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1466-1268</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>4</Issue><PubDate><Year>2017</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Cell stress & chaperones</Title><ISOAbbreviation>Cell Stress Chaperones</ISOAbbreviation></Journal><ArticleTitle>The growing world of small heat shock proteins: from structure to functions.</ArticleTitle><Pagination><MedlinePgn>601-611</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s12192-017-0787-8</ELocationID><Abstract><AbstractText>Small heat shock proteins (sHSPs) are present in all kingdoms of life and play fundamental roles in cell biology. sHSPs are key components of the cellular protein quality control system, acting as the first line of defense against conditions that affect protein homeostasis and proteome stability, from bacteria to plants to humans. sHSPs have the ability to bind to a large subset of substrates and to maintain them in a state competent for refolding or clearance with the assistance of the HSP70 machinery. sHSPs participate in a number of biological processes, from the cell cycle, to cell differentiation, from adaptation to stressful conditions, to apoptosis, and, even, to the transformation of a cell into a malignant state. As a consequence, sHSP malfunction has been implicated in abnormal placental development and preterm deliveries, in the prognosis of several types of cancer, and in the development of neurological diseases. Moreover, mutations in the genes encoding several mammalian sHSPs result in neurological, muscular, or cardiac age-related diseases in humans. Loss of protein homeostasis due to protein aggregation is typical of many age-related neurodegenerative and neuromuscular diseases. In light of the role of sHSPs in the clearance of un/misfolded aggregation-prone substrates, pharmacological modulation of sHSP expression or function and rescue of defective sHSPs represent possible routes to alleviate or cure protein conformation diseases. Here, we report the latest news and views on sHSPs discussed by many of the world's experts in the sHSP field during a dedicated workshop organized in Italy (Bertinoro, CEUB, October 12-15, 2016).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Carra</LastName><ForeName>Serena</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biomedical, Metabolic and Neural Sciences, and Centre for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, via G. Campi 287, 41125, Modena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alberti</LastName><ForeName>Simon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arrigo</LastName><ForeName>Patrick A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Université de Lyon, 69622, Lyon, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, UMR 5310, INSERM U1217, Institut NeuroMyoGène, Université Lyon 1, 69100, Villeurbanne, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benesch</LastName><ForeName>Justin L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Department of Chemistry, University of Oxford, Oxford, OX1 3TA, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benjamin</LastName><ForeName>Ivor J</ForeName><Initials>IJ</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Utah, Salt Lake City, UT, 84112-5650, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boelens</LastName><ForeName>Wilbert</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Biomolecular Chemistry, 284, Radboud University, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bartelt-Kirbach</LastName><ForeName>Britta</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institute of Anatomy and Cell Biology, University of Ulm, 89081, Ulm, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brundel</LastName><ForeName>Bianca J J M</ForeName><Initials>BJJM</Initials><AffiliationInfo><Affiliation>Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buchner</LastName><ForeName>Johannes</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Technische Universitat Munchen, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bukau</LastName><ForeName>Bernd</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Center for Molecular Biology of the University of Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carver</LastName><ForeName>John A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>The Research School of Chemistry, The Australian National University, Acton, ACT, 2601, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ecroyd</LastName><ForeName>Heath</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Illawara Health and Medical Research Institute, School of Biological Sciences, University of Wollongong, Wollongong, NSW, 2522, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Emanuelsson</LastName><ForeName>Cecilia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University, 221 00, Lund, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Finet</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>IMPMC UMR7590, CNRS, UPMC Paris 6, 4 place Jussieu, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Golenhofen</LastName><ForeName>Nikola</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Institute of Anatomy and Cell Biology, University of Ulm, 89081, Ulm, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goloubinoff</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Plant Molecular Biology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gusev</LastName><ForeName>Nikolai</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, School of Biology, Moscow State University, Moscow, 119991, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haslbeck</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Technische Universitat Munchen, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hightower</LastName><ForeName>Lawrence E</ForeName><Initials>LE</Initials><AffiliationInfo><Affiliation>Department of Molecular & Cell Biology, University of Connecticut, 91 North Eagleville Road, Storrs, CT, 06269-3125, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kampinga</LastName><ForeName>Harm H</ForeName><Initials>HH</Initials><AffiliationInfo><Affiliation>Department of Cell Biology, University Medical Center Groningen, University of Groningen, 9713 GZ, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klevit</LastName><ForeName>Rachel E</ForeName><Initials>RE</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liberek</LastName><ForeName>Krzysztof</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Molecular and Cellular Biology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and the Medical University of Gdańsk, Gdańsk, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mchaourab</LastName><ForeName>Hassane S</ForeName><Initials>HS</Initials><AffiliationInfo><Affiliation>Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McMenimen</LastName><ForeName>Kathryn A</ForeName><Initials>KA</Initials><AffiliationInfo><Affiliation>Departments of Pathology, Biological Chemistry, and Medicinal Chemistry and the Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Poletti</LastName><ForeName>Angelo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quinlan</LastName><ForeName>Roy</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Biosciences and the Biophysical Sciences Institute, University of Durham, Durham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Strelkov</LastName><ForeName>Sergei V</ForeName><Initials>SV</Initials><AffiliationInfo><Affiliation>Laboratory for Biocrystallography, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Toth</LastName><ForeName>Melinda E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>Laboratory of Animal Genetics and Molecular Neurobiology, Institute of Biochemistry, Biological Research Centre, Szeged, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vierling</LastName><ForeName>Elizabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA, 01003, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, 85721, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tanguay</LastName><ForeName>Robert M</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>Laboratory of Cell & Developmental Genetics, IBIS, and Department of Molecular Biology, Medical Biochemistry and Pathology, Medical School, Université Laval, Québec (Qc), G1V 0A6, Canada. Robert.tanguay@fmed.ulaval.ca.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R15 GM120654</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>03</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Cell Stress Chaperones</MedlineTA><NlmUniqueID>9610925</NlmUniqueID><ISSNLinking>1355-8145</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Mol Evol. 1995 Mar;40(3):238-48</RefSource><PMID Version="1">7723051</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Chem Biol. 2006 Jun;13(6):597-605</RefSource><PMID 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