Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment.
Identifieur interne : 000849 ( PubMed/Curation ); précédent : 000848; suivant : 000850Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment.
Auteurs : M M Juki [Suède] ; N. Opel [Allemagne] ; J. Ström [Suède] ; T. Carrillo-Roa [Allemagne] ; S. Miksys [Canada] ; M. Novalen [Canada] ; A. Renblom [Suède] ; S C Sim [Suède] ; E M Pe As-Lled [Espagne] ; P. Courtet [France] ; A. Llerena [Canada] ; B T Baune [Australie] ; D J De Quervain [Suisse] ; A. Papassotiropoulos [Suisse] ; R F Tyndale [Canada] ; E B Binder [Allemagne] ; U. Dannlowski [Allemagne] ; M. Ingelman-Sundberg [Suède]Source :
- Molecular psychiatry [ 1476-5578 ] ; 2017.
Descripteurs français
- KwdFr :
- Afro-Américains (génétique), Agonistes des récepteurs 5-HT1 de la sérotonine (pharmacologie), Animaux, Anxiété (génétique), Anxiété (imagerie diagnostique), Citalopram (pharmacologie), Comportement animal (), Cytochrome P-450 CYP2C19 (), Cytochrome P-450 CYP2C19 (génétique), Cytochrome P-450 CYP2C19 (métabolisme), Dépression (génétique), Dépression (traitement médicamenteux), Facteur neurotrophique dérivé du cerveau (métabolisme), Hippocampe (métabolisme), Homéostasie (génétique), Homéostasie (physiologie), Humains, Neurogenèse (génétique), Récepteur de la sérotonine de type 5-HT1A (métabolisme), Souris, Souris transgéniques, Sérotonine (métabolisme), Trouble dépressif majeur (imagerie diagnostique), Trouble dépressif majeur (métabolisme), Troubles anxieux (génétique).
- MESH :
- génétique : Afro-Américains, Anxiété, Cytochrome P-450 CYP2C19, Dépression, Homéostasie, Neurogenèse, Troubles anxieux.
- imagerie diagnostique : Anxiété, Trouble dépressif majeur.
- métabolisme : Cytochrome P-450 CYP2C19, Facteur neurotrophique dérivé du cerveau, Hippocampe, Récepteur de la sérotonine de type 5-HT1A, Sérotonine, Trouble dépressif majeur.
- pharmacologie : Agonistes des récepteurs 5-HT1 de la sérotonine, Citalopram.
- physiologie : Homéostasie.
- traitement médicamenteux : Dépression.
- Animaux, Comportement animal, Cytochrome P-450 CYP2C19, Humains, Souris, Souris transgéniques.
English descriptors
- KwdEn :
- African Americans (genetics), Animals, Anxiety (diagnostic imaging), Anxiety (genetics), Anxiety Disorders (genetics), Behavior, Animal (drug effects), Brain-Derived Neurotrophic Factor (metabolism), Citalopram (pharmacology), Cytochrome P-450 CYP2C19 (drug effects), Cytochrome P-450 CYP2C19 (genetics), Cytochrome P-450 CYP2C19 (metabolism), Depression (drug therapy), Depression (genetics), Depressive Disorder, Major (diagnostic imaging), Depressive Disorder, Major (metabolism), Hippocampus (metabolism), Homeostasis (genetics), Homeostasis (physiology), Humans, Mice, Mice, Transgenic, Neurogenesis (genetics), Receptor, Serotonin, 5-HT1A (metabolism), Serotonin (metabolism), Serotonin 5-HT1 Receptor Agonists (pharmacology).
- MESH :
- chemical , drug effects : Cytochrome P-450 CYP2C19.
- chemical , genetics : Cytochrome P-450 CYP2C19.
- chemical , metabolism : Brain-Derived Neurotrophic Factor, Cytochrome P-450 CYP2C19, Receptor, Serotonin, 5-HT1A, Serotonin.
- diagnostic imaging : Anxiety, Depressive Disorder, Major.
- drug effects : Behavior, Animal.
- drug therapy : Depression.
- genetics : African Americans, Anxiety, Anxiety Disorders, Depression, Homeostasis, Neurogenesis.
- metabolism : Depressive Disorder, Major, Hippocampus.
- chemical , pharmacology : Citalopram, Serotonin 5-HT1 Receptor Agonists.
- physiology : Homeostasis.
- Animals, Humans, Mice, Mice, Transgenic.
Abstract
The polymorphic CYP2C19 enzyme metabolizes psychoactive compounds and is expressed in the adult liver and fetal brain. Previously, we demonstrated that the absence of CYP2C19 is associated with lower levels of depressive symptoms in 1472 Swedes. Conversely, transgenic mice carrying the human CYP2C19 gene (2C19TG) have shown an anxious phenotype and decrease in hippocampal volume and adult neurogenesis. The aims of this study were to: (1) examine whether the 2C19TG findings could be translated to humans, (2) evaluate the usefulness of the 2C19TG strain as a tool for preclinical screening of new antidepressants and (3) provide an insight into the molecular underpinnings of the 2C19TG phenotype. In humans, we found that the absence of CYP2C19 was associated with a bilateral hippocampal volume increase in two independent healthy cohorts (N=386 and 1032) and a lower prevalence of major depressive disorder and depression severity in African-Americans (N=3848). Moreover, genetically determined high CYP2C19 enzymatic capacity was associated with higher suicidality in depressed suicide attempters (N=209). 2C19TG mice showed high stress sensitivity, impaired hippocampal Bdnf homeostasis in stress, and more despair-like behavior in the forced swim test (FST). After the treatment with citalopram and 5-HT1A receptor agonist 8OH-DPAT, the reduction in immobility time in the FST was more pronounced in 2C19TG mice compared with WTs. Conversely, in the 2C19TG hippocampus, metabolic turnover of serotonin was reduced, whereas ERK1/2 and GSK3β phosphorylation was increased. Altogether, this study indicates that elevated CYP2C19 expression is associated with depressive symptoms, reduced hippocampal volume and impairment of hippocampal serotonin and BDNF homeostasis.
DOI: 10.1038/mp.2016.204
PubMed: 27895323
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<author><name sortKey="Juki, M M" sort="Juki, M M" uniqKey="Juki M" first="M M" last="Juki">M M Juki</name>
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<author><name sortKey="Opel, N" sort="Opel, N" uniqKey="Opel N" first="N" last="Opel">N. Opel</name>
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<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Strom, J" sort="Strom, J" uniqKey="Strom J" first="J" last="Ström">J. Ström</name>
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<country xml:lang="fr">Suède</country>
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<author><name sortKey="Carrillo Roa, T" sort="Carrillo Roa, T" uniqKey="Carrillo Roa T" first="T" last="Carrillo-Roa">T. Carrillo-Roa</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich</wicri:regionArea>
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<author><name sortKey="Miksys, S" sort="Miksys, S" uniqKey="Miksys S" first="S" last="Miksys">S. Miksys</name>
<affiliation wicri:level="1"><nlm:affiliation>Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
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<author><name sortKey="Novalen, M" sort="Novalen, M" uniqKey="Novalen M" first="M" last="Novalen">M. Novalen</name>
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<country xml:lang="fr">Canada</country>
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</affiliation>
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<author><name sortKey="Renblom, A" sort="Renblom, A" uniqKey="Renblom A" first="A" last="Renblom">A. Renblom</name>
<affiliation wicri:level="1"><nlm:affiliation>Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm</wicri:regionArea>
</affiliation>
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<author><name sortKey="Sim, S C" sort="Sim, S C" uniqKey="Sim S" first="S C" last="Sim">S C Sim</name>
<affiliation wicri:level="1"><nlm:affiliation>Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
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<author><name sortKey="Pe As Lled, E M" sort="Pe As Lled, E M" uniqKey="Pe As Lled E" first="E M" last="Pe As-Lled">E M Pe As-Lled</name>
<affiliation wicri:level="1"><nlm:affiliation>CICAB Clinical Research Center, Extremadura University Hospital and Medical School, Badajoz, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CICAB Clinical Research Center, Extremadura University Hospital and Medical School, Badajoz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Courtet, P" sort="Courtet, P" uniqKey="Courtet P" first="P" last="Courtet">P. Courtet</name>
<affiliation wicri:level="1"><nlm:affiliation>CHU Montpellier, Hôpital Lapeyronie, Psychiatric Emergency and Post-Acute Care Department, Pole Urgence, Montpellier, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU Montpellier, Hôpital Lapeyronie, Psychiatric Emergency and Post-Acute Care Department, Pole Urgence, Montpellier</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Llerena, A" sort="Llerena, A" uniqKey="Llerena A" first="A" last="Llerena">A. Llerena</name>
<affiliation wicri:level="1"><nlm:affiliation>Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baune, B T" sort="Baune, B T" uniqKey="Baune B" first="B T" last="Baune">B T Baune</name>
<affiliation wicri:level="1"><nlm:affiliation>Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA</wicri:regionArea>
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<author><name sortKey="De Quervain, D J" sort="De Quervain, D J" uniqKey="De Quervain D" first="D J" last="De Quervain">D J De Quervain</name>
<affiliation wicri:level="1"><nlm:affiliation>Transfaculty Research Platform, Department of Psychology, University Psychiatric Clinics, University of Basel, Basel, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Transfaculty Research Platform, Department of Psychology, University Psychiatric Clinics, University of Basel, Basel</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Papassotiropoulos, A" sort="Papassotiropoulos, A" uniqKey="Papassotiropoulos A" first="A" last="Papassotiropoulos">A. Papassotiropoulos</name>
<affiliation wicri:level="1"><nlm:affiliation>Transfaculty Research Platform, Department of Psychology, University Psychiatric Clinics, University of Basel, Basel, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Transfaculty Research Platform, Department of Psychology, University Psychiatric Clinics, University of Basel, Basel</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tyndale, R F" sort="Tyndale, R F" uniqKey="Tyndale R" first="R F" last="Tyndale">R F Tyndale</name>
<affiliation wicri:level="1"><nlm:affiliation>Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Binder, E B" sort="Binder, E B" uniqKey="Binder E" first="E B" last="Binder">E B Binder</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dannlowski, U" sort="Dannlowski, U" uniqKey="Dannlowski U" first="U" last="Dannlowski">U. Dannlowski</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Münster, Münster, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, University of Münster, Münster</wicri:regionArea>
</affiliation>
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<author><name sortKey="Ingelman Sundberg, M" sort="Ingelman Sundberg, M" uniqKey="Ingelman Sundberg M" first="M" last="Ingelman-Sundberg">M. Ingelman-Sundberg</name>
<affiliation wicri:level="1"><nlm:affiliation>Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm</wicri:regionArea>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>African Americans (genetics)</term>
<term>Animals</term>
<term>Anxiety (diagnostic imaging)</term>
<term>Anxiety (genetics)</term>
<term>Anxiety Disorders (genetics)</term>
<term>Behavior, Animal (drug effects)</term>
<term>Brain-Derived Neurotrophic Factor (metabolism)</term>
<term>Citalopram (pharmacology)</term>
<term>Cytochrome P-450 CYP2C19 (drug effects)</term>
<term>Cytochrome P-450 CYP2C19 (genetics)</term>
<term>Cytochrome P-450 CYP2C19 (metabolism)</term>
<term>Depression (drug therapy)</term>
<term>Depression (genetics)</term>
<term>Depressive Disorder, Major (diagnostic imaging)</term>
<term>Depressive Disorder, Major (metabolism)</term>
<term>Hippocampus (metabolism)</term>
<term>Homeostasis (genetics)</term>
<term>Homeostasis (physiology)</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
<term>Neurogenesis (genetics)</term>
<term>Receptor, Serotonin, 5-HT1A (metabolism)</term>
<term>Serotonin (metabolism)</term>
<term>Serotonin 5-HT1 Receptor Agonists (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Afro-Américains (génétique)</term>
<term>Agonistes des récepteurs 5-HT1 de la sérotonine (pharmacologie)</term>
<term>Animaux</term>
<term>Anxiété (génétique)</term>
<term>Anxiété (imagerie diagnostique)</term>
<term>Citalopram (pharmacologie)</term>
<term>Comportement animal ()</term>
<term>Cytochrome P-450 CYP2C19 ()</term>
<term>Cytochrome P-450 CYP2C19 (génétique)</term>
<term>Cytochrome P-450 CYP2C19 (métabolisme)</term>
<term>Dépression (génétique)</term>
<term>Dépression (traitement médicamenteux)</term>
<term>Facteur neurotrophique dérivé du cerveau (métabolisme)</term>
<term>Hippocampe (métabolisme)</term>
<term>Homéostasie (génétique)</term>
<term>Homéostasie (physiologie)</term>
<term>Humains</term>
<term>Neurogenèse (génétique)</term>
<term>Récepteur de la sérotonine de type 5-HT1A (métabolisme)</term>
<term>Souris</term>
<term>Souris transgéniques</term>
<term>Sérotonine (métabolisme)</term>
<term>Trouble dépressif majeur (imagerie diagnostique)</term>
<term>Trouble dépressif majeur (métabolisme)</term>
<term>Troubles anxieux (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Cytochrome P-450 CYP2C19</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytochrome P-450 CYP2C19</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Brain-Derived Neurotrophic Factor</term>
<term>Cytochrome P-450 CYP2C19</term>
<term>Receptor, Serotonin, 5-HT1A</term>
<term>Serotonin</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Anxiety</term>
<term>Depressive Disorder, Major</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Behavior, Animal</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Depression</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>African Americans</term>
<term>Anxiety</term>
<term>Anxiety Disorders</term>
<term>Depression</term>
<term>Homeostasis</term>
<term>Neurogenesis</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Afro-Américains</term>
<term>Anxiété</term>
<term>Cytochrome P-450 CYP2C19</term>
<term>Dépression</term>
<term>Homéostasie</term>
<term>Neurogenèse</term>
<term>Troubles anxieux</term>
</keywords>
<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Anxiété</term>
<term>Trouble dépressif majeur</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Depressive Disorder, Major</term>
<term>Hippocampus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytochrome P-450 CYP2C19</term>
<term>Facteur neurotrophique dérivé du cerveau</term>
<term>Hippocampe</term>
<term>Récepteur de la sérotonine de type 5-HT1A</term>
<term>Sérotonine</term>
<term>Trouble dépressif majeur</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agonistes des récepteurs 5-HT1 de la sérotonine</term>
<term>Citalopram</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Citalopram</term>
<term>Serotonin 5-HT1 Receptor Agonists</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Homéostasie</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Homeostasis</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Dépression</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Comportement animal</term>
<term>Cytochrome P-450 CYP2C19</term>
<term>Humains</term>
<term>Souris</term>
<term>Souris transgéniques</term>
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<front><div type="abstract" xml:lang="en">The polymorphic CYP2C19 enzyme metabolizes psychoactive compounds and is expressed in the adult liver and fetal brain. Previously, we demonstrated that the absence of CYP2C19 is associated with lower levels of depressive symptoms in 1472 Swedes. Conversely, transgenic mice carrying the human CYP2C19 gene (2C19TG) have shown an anxious phenotype and decrease in hippocampal volume and adult neurogenesis. The aims of this study were to: (1) examine whether the 2C19TG findings could be translated to humans, (2) evaluate the usefulness of the 2C19TG strain as a tool for preclinical screening of new antidepressants and (3) provide an insight into the molecular underpinnings of the 2C19TG phenotype. In humans, we found that the absence of CYP2C19 was associated with a bilateral hippocampal volume increase in two independent healthy cohorts (N=386 and 1032) and a lower prevalence of major depressive disorder and depression severity in African-Americans (N=3848). Moreover, genetically determined high CYP2C19 enzymatic capacity was associated with higher suicidality in depressed suicide attempters (N=209). 2C19TG mice showed high stress sensitivity, impaired hippocampal Bdnf homeostasis in stress, and more despair-like behavior in the forced swim test (FST). After the treatment with citalopram and 5-HT1A receptor agonist 8OH-DPAT, the reduction in immobility time in the FST was more pronounced in 2C19TG mice compared with WTs. Conversely, in the 2C19TG hippocampus, metabolic turnover of serotonin was reduced, whereas ERK1/2 and GSK3β phosphorylation was increased. Altogether, this study indicates that elevated CYP2C19 expression is associated with depressive symptoms, reduced hippocampal volume and impairment of hippocampal serotonin and BDNF homeostasis.</div>
</front>
</TEI>
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<DateCreated><Year>2016</Year>
<Month>11</Month>
<Day>29</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>11</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-5578</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>22</Volume>
<Issue>8</Issue>
<PubDate><Year>2017</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>Molecular psychiatry</Title>
<ISOAbbreviation>Mol. Psychiatry</ISOAbbreviation>
</Journal>
<ArticleTitle>Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment.</ArticleTitle>
<Pagination><MedlinePgn>1155-1163</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/mp.2016.204</ELocationID>
<Abstract><AbstractText>The polymorphic CYP2C19 enzyme metabolizes psychoactive compounds and is expressed in the adult liver and fetal brain. Previously, we demonstrated that the absence of CYP2C19 is associated with lower levels of depressive symptoms in 1472 Swedes. Conversely, transgenic mice carrying the human CYP2C19 gene (2C19TG) have shown an anxious phenotype and decrease in hippocampal volume and adult neurogenesis. The aims of this study were to: (1) examine whether the 2C19TG findings could be translated to humans, (2) evaluate the usefulness of the 2C19TG strain as a tool for preclinical screening of new antidepressants and (3) provide an insight into the molecular underpinnings of the 2C19TG phenotype. In humans, we found that the absence of CYP2C19 was associated with a bilateral hippocampal volume increase in two independent healthy cohorts (N=386 and 1032) and a lower prevalence of major depressive disorder and depression severity in African-Americans (N=3848). Moreover, genetically determined high CYP2C19 enzymatic capacity was associated with higher suicidality in depressed suicide attempters (N=209). 2C19TG mice showed high stress sensitivity, impaired hippocampal Bdnf homeostasis in stress, and more despair-like behavior in the forced swim test (FST). After the treatment with citalopram and 5-HT1A receptor agonist 8OH-DPAT, the reduction in immobility time in the FST was more pronounced in 2C19TG mice compared with WTs. Conversely, in the 2C19TG hippocampus, metabolic turnover of serotonin was reduced, whereas ERK1/2 and GSK3β phosphorylation was increased. Altogether, this study indicates that elevated CYP2C19 expression is associated with depressive symptoms, reduced hippocampal volume and impairment of hippocampal serotonin and BDNF homeostasis.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jukić</LastName>
<ForeName>M M</ForeName>
<Initials>MM</Initials>
<AffiliationInfo><Affiliation>Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Opel</LastName>
<ForeName>N</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, University of Münster, Münster, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ström</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carrillo-Roa</LastName>
<ForeName>T</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Miksys</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Psychiatry, University of Toronto, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Novalen</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Psychiatry, University of Toronto, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Renblom</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sim</LastName>
<ForeName>S C</ForeName>
<Initials>SC</Initials>
<AffiliationInfo><Affiliation>Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Peñas-Lledó</LastName>
<ForeName>E M</ForeName>
<Initials>EM</Initials>
<AffiliationInfo><Affiliation>CICAB Clinical Research Center, Extremadura University Hospital and Medical School, Badajoz, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CIBERSAM, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Courtet</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>CHU Montpellier, Hôpital Lapeyronie, Psychiatric Emergency and Post-Acute Care Department, Pole Urgence, Montpellier, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Llerena</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Psychiatry, University of Toronto, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Baune</LastName>
<ForeName>B T</ForeName>
<Initials>BT</Initials>
<AffiliationInfo><Affiliation>Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Quervain</LastName>
<ForeName>D J</ForeName>
<Initials>DJ</Initials>
<AffiliationInfo><Affiliation>Transfaculty Research Platform, Department of Psychology, University Psychiatric Clinics, University of Basel, Basel, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Papassotiropoulos</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Transfaculty Research Platform, Department of Psychology, University Psychiatric Clinics, University of Basel, Basel, Switzerland.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Life Sciences Training Facility, Department Biozentrum, University of Basel, Basel, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tyndale</LastName>
<ForeName>R F</ForeName>
<Initials>RF</Initials>
<AffiliationInfo><Affiliation>Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Psychiatry, University of Toronto, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Binder</LastName>
<ForeName>E B</ForeName>
<Initials>EB</Initials>
<AffiliationInfo><Affiliation>Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dannlowski</LastName>
<ForeName>U</ForeName>
<Initials>U</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, University of Münster, Münster, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Psychiatry, University of Marburg, Marburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ingelman-Sundberg</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>11</Month>
<Day>29</Day>
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<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Mol Psychiatry</MedlineTA>
<NlmUniqueID>9607835</NlmUniqueID>
<ISSNLinking>1359-4184</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019208">Brain-Derived Neurotrophic Factor</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D058825">Serotonin 5-HT1 Receptor Agonists</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C579455">brain-derived neurotrophic factor, human</NameOfSubstance>
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<Chemical><RegistryNumber>0DHU5B8D6V</RegistryNumber>
<NameOfSubstance UI="D015283">Citalopram</NameOfSubstance>
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<Chemical><RegistryNumber>112692-38-3</RegistryNumber>
<NameOfSubstance UI="D044282">Receptor, Serotonin, 5-HT1A</NameOfSubstance>
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<Chemical><RegistryNumber>333DO1RDJY</RegistryNumber>
<NameOfSubstance UI="D012701">Serotonin</NameOfSubstance>
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<Chemical><RegistryNumber>EC 1.14.14.1</RegistryNumber>
<NameOfSubstance UI="C045793">CYP2C19 protein, human</NameOfSubstance>
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<Chemical><RegistryNumber>EC 1.14.14.1</RegistryNumber>
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<CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>Mol Psychiatry. 2017 Aug;22(8):1224</RefSource>
<PMID Version="1">28416806</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 2012 Dec 15;380(9859):2163-96</RefSource>
<PMID Version="1">23245607</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Pharmacol Ther. 2006 Jan;79(1):103-13</RefSource>
<PMID Version="1">16413245</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neuropsychopharmacology. 2014 Nov;39(12):2723-31</RefSource>
<PMID Version="1">24924799</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Psychiatry. 2003 Feb;160(2):334-40</RefSource>
<PMID Version="1">12562581</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurosci Lett. 2002 Mar 1;320(1-2):91-5</RefSource>
<PMID Version="1">11849771</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2013 Jul 1;74(1):62-8</RefSource>
<PMID Version="1">23419546</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Methods Enzymol. 1996;272:210-8</RefSource>
<PMID Version="1">8791779</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Affect Disord. 2016 Jan 1;189:199-202</RefSource>
<PMID Version="1">26451503</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Neuropsychopharmacol. 2014 May;17(5):779-91</RefSource>
<PMID Version="1">24451568</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neuron. 2011 Jun 9;70(5):908-23</RefSource>
<PMID Version="1">21658584</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2013 Apr 1;73(7):658-66</RefSource>
<PMID Version="1">23237316</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2015 Nov;18(11):1606-16</RefSource>
<PMID Version="1">26389840</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Br J Clin Pharmacol. 2010 Mar;69(3):222-30</RefSource>
<PMID Version="1">20233192</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2015 Apr;16(4):189-200</RefSource>
<PMID Version="1">25790864</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Fam Med. 2015 Jan-Feb;13(1):69-79</RefSource>
<PMID Version="1">25583895</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurosci Lett. 2012 Jul 11;521(1):20-5</RefSource>
<PMID Version="1">22622174</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Drug Metab Dispos. 2008 May;36(5):955-62</RefSource>
<PMID Version="1">18276835</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Opin Neurobiol. 2015 Feb;30:51-8</RefSource>
<PMID Version="1">25240202</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Med Genet B Neuropsychiatr Genet. 2010 Sep;153B(6):1160-6</RefSource>
<PMID Version="1">20468063</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2015 Apr 9;520(7546):224-9</RefSource>
<PMID Version="1">25607358</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 1997 Jul 15;17(14):5591-8</RefSource>
<PMID Version="1">9204940</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neuron. 2010 Jan 14;65(1):40-52</RefSource>
<PMID Version="1">20152112</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neuropsychopharmacology. 2006 Oct;31(10):2274-80</RefSource>
<PMID Version="1">16641936</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2010 Nov;16(11):1328-32</RefSource>
<PMID Version="1">20953200</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurol Ther. 2014 Jan 03;3(1):67-77</RefSource>
<PMID Version="1">26000223</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2014 Jan 16;9(1):e83879</RefSource>
<PMID Version="1">24454710</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Psychopharmacology (Berl). 2003 Mar;166(3):284-93</RefSource>
<PMID Version="1">12589521</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nucl Med Biol. 2007 Oct;34(7):865-77</RefSource>
<PMID Version="1">17921037</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Pharmacol Ther. 2007 Dec;116(3):496-526</RefSource>
<PMID Version="1">18001838</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2011 Aug 03;476(7361):458-61</RefSource>
<PMID Version="1">21814201</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Psychiatry. 2014 Nov;19(11):1171-8</RefSource>
<PMID Version="1">24342991</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2011 Mar 23;31(12):4475-83</RefSource>
<PMID Version="1">21430148</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neural Transm (Vienna). 2003 Dec;110(12):1445-53</RefSource>
<PMID Version="1">14666415</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Psychiatry. 2015 Feb;20(1):32-47</RefSource>
<PMID Version="1">25486982</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 2003 Aug 8;301(5634):805-9</RefSource>
<PMID Version="1">12907793</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Psychiatry. 2015 Nov;20(11):1266-85</RefSource>
<PMID Version="1">26283638</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Behav Brain Res. 2011 Jan 20;216(2):585-91</RefSource>
<PMID Version="1">20816900</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Neuropsychopharmacol. 2008 Jun;11(4):465-76</RefSource>
<PMID Version="1">17971260</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Psychiatry. 2014 Jun;19(6):733-41</RefSource>
<PMID Version="1">23877834</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neuropsychopharmacology. 2015 Mar;40(4):839-48</RefSource>
<PMID Version="1">25241801</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Life Sci. 2002 Nov 1;71(24):2867-2880</RefSource>
<PMID Version="1">12377268</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurochem. 1986 Sep;47(3):958-65</RefSource>
<PMID Version="1">2426412</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur J Pharmacol. 2015 Sep 5;762:127-35</RefSource>
<PMID Version="1">26004533</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Psychiatry. 2016 Jun;21(6):806-12</RefSource>
<PMID Version="1">26122586</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 1966 Aug 12;153(3737):767-8</RefSource>
<PMID Version="1">5940897</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neuron. 2009 May 28;62(4):479-93</RefSource>
<PMID Version="1">19477151</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2011 Apr 20;31(16):6008-18</RefSource>
<PMID Version="1">21508226</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2013 Nov;10(11):e1001547</RefSource>
<PMID Version="1">24223526</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell Signal. 2010 Oct;22(10):1406-12</RefSource>
<PMID Version="1">20363322</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Psychol Med. 2014 Aug;44(11):2255-69</RefSource>
<PMID Version="1">24262766</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neuropsychopharmacology. 2015 Mar 13;40(5):1216-21</RefSource>
<PMID Version="1">25409592</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2008 Jan 3;358(1):55-68</RefSource>
<PMID Version="1">18172175</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Med. 1998 Nov;4(11):1313-7</RefSource>
<PMID Version="1">9809557</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Trends Pharmacol Sci. 2011 Dec;32(12):708-14</RefSource>
<PMID Version="1">21975165</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2005 Feb 2;25(5):1089-94</RefSource>
<PMID Version="1">15689544</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neuropsychopharmacology. 2014 Feb;39(3):770-9</RefSource>
<PMID Version="1">24220026</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2015 Feb 1;77(3):285-94</RefSource>
<PMID Version="1">25109665</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Pharmacopsychiatry. 1995 Mar;28(2):45-50</RefSource>
<PMID Version="1">7542785</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2011 Jun 15;475(7354):91-5</RefSource>
<PMID Version="1">21677641</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
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