Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study.
Identifieur interne : 000823 ( PubMed/Curation ); précédent : 000822; suivant : 000824Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study.
Auteurs : John G. Laffey [Canada] ; Fabiana Madotto [Italie] ; Giacomo Bellani [Italie] ; Tài Pham [France] ; Eddy Fan [Canada] ; Laurent Brochard [Canada] ; Pravin Amin [Inde] ; Yaseen Arabi [Arabie saoudite] ; Ednan K. Bajwa [États-Unis] ; Alejandro Bruhn [Chili] ; Vladimir Cerny [République tchèque] ; Kevin Clarkson [Irlande (pays)] ; Leo Heunks [Pays-Bas] ; Kiyoyasu Kurahashi [Japon] ; Jon Henrik Laake [Norvège] ; Jose A. Lorente [Espagne] ; Lia Mcnamee [Royaume-Uni] ; Nicolas Nin [Uruguay] ; Jose Emmanuel Palo [Philippines] ; Lise Piquilloud [France] ; Haibo Qiu [République populaire de Chine] ; Juan Ignacio Silesky Jiménez [Costa Rica] ; Andres Esteban [Uruguay] ; Daniel F. Mcauley [Royaume-Uni] ; Frank Van Haren [Australie] ; Marco Ranieri [Italie] ; Gordon Rubenfeld [Canada] ; Hermann Wrigge [Allemagne] ; Arthur S. Slutsky [Canada] ; Antonio Pesenti [Italie]Source :
- The Lancet. Respiratory medicine [ 2213-2619 ] ; 2017.
Abstract
Little information is available about the geo-economic variations in demographics, management, and outcomes of patients with acute respiratory distress syndrome (ARDS). We aimed to characterise the effect of these geo-economic variations in patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE).
DOI: 10.1016/S2213-2600(17)30213-8
PubMed: 28624388
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Electronic address: laffeyj@smh.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anesthesia, St Michael's Hospital, Toronto, ON, Canada; Department of Critical Care Medicine, St Michael's Hospital, Toronto, ON, Canada; Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Department of Anesthesia, University of Toronto, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON</wicri:regionArea></affiliation></author><author><name sortKey="Madotto, Fabiana" sort="Madotto, Fabiana" uniqKey="Madotto F" first="Fabiana" last="Madotto">Fabiana Madotto</name><affiliation wicri:level="1"><nlm:affiliation>Research Center on Public Health, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Research Center on Public Health, Department of Medicine and Surgery, University of Milano-Bicocca, Monza</wicri:regionArea></affiliation></author><author><name sortKey="Bellani, Giacomo" sort="Bellani, Giacomo" uniqKey="Bellani G" first="Giacomo" last="Bellani">Giacomo Bellani</name><affiliation wicri:level="1"><nlm:affiliation>Research Center on Public Health, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; Department of Emergency and Intensive Care, San Gerardo Hospital, Monza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Research Center on Public Health, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; Department of Emergency and Intensive Care, San Gerardo Hospital, Monza</wicri:regionArea></affiliation></author><author><name sortKey="Pham, Tai" sort="Pham, Tai" uniqKey="Pham T" first="Tài" last="Pham">Tài Pham</name><affiliation wicri:level="1"><nlm:affiliation>Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Sorbonne Universités, UPMC Université Paris 06, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Sorbonne Universités, UPMC Université Paris 06, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Fan, Eddy" sort="Fan, Eddy" uniqKey="Fan E" first="Eddy" last="Fan">Eddy Fan</name><affiliation wicri:level="1"><nlm:affiliation>Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; Department of Medicine, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; Department of Medicine, University Health Network and Mount Sinai Hospital, Toronto, ON</wicri:regionArea></affiliation></author><author><name sortKey="Brochard, Laurent" sort="Brochard, Laurent" uniqKey="Brochard L" first="Laurent" last="Brochard">Laurent Brochard</name><affiliation wicri:level="1"><nlm:affiliation>Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON</wicri:regionArea></affiliation></author><author><name sortKey="Amin, Pravin" sort="Amin, Pravin" uniqKey="Amin P" first="Pravin" last="Amin">Pravin Amin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Bombay Hospital Institute of Medical Sciences, Mumbai, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Critical Care Medicine, Bombay Hospital Institute of Medical Sciences, Mumbai</wicri:regionArea></affiliation></author><author><name sortKey="Arabi, Yaseen" sort="Arabi, Yaseen" uniqKey="Arabi Y" first="Yaseen" last="Arabi">Yaseen Arabi</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; Respiratory Services, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; Respiratory Services, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh</wicri:regionArea></affiliation></author><author><name sortKey="Bajwa, Ednan K" sort="Bajwa, Ednan K" uniqKey="Bajwa E" first="Ednan K" last="Bajwa">Ednan K. Bajwa</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pulmonary and Critical Care, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary and Critical Care, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Bruhn, Alejandro" sort="Bruhn, Alejandro" uniqKey="Bruhn A" first="Alejandro" last="Bruhn">Alejandro Bruhn</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago</wicri:regionArea></affiliation></author><author><name sortKey="Cerny, Vladimir" sort="Cerny, Vladimir" uniqKey="Cerny V" first="Vladimir" last="Cerny">Vladimir Cerny</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology, Perioperative Medicine and Intensive Care, J E Purkinje University, Masaryk Hospital, Usti nad Labem, Czech Republic; Department of Research and Development, and Department of Anesthesiology and Intensive Care, Charles University in Prague, Prague, Czech Republic; Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Anesthesiology, Perioperative Medicine and Intensive Care, J E Purkinje University, Masaryk Hospital, Usti nad Labem, Czech Republic; Department of Research and Development, and Department of Anesthesiology and Intensive Care, Charles University in Prague, Prague, Czech Republic; Faculty of Medicine in Hradec Kralove, Hradec Kralove</wicri:regionArea></affiliation></author><author><name sortKey="Clarkson, Kevin" sort="Clarkson, Kevin" uniqKey="Clarkson K" first="Kevin" last="Clarkson">Kevin Clarkson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anaesthesia, Galway University Hospitals and National University of Ireland, Galway, Galway, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Anaesthesia, Galway University Hospitals and National University of Ireland, Galway, Galway</wicri:regionArea></affiliation></author><author><name sortKey="Heunks, Leo" sort="Heunks, Leo" uniqKey="Heunks L" first="Leo" last="Heunks">Leo Heunks</name><affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care, VU University Medical Centre Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Intensive Care, VU University Medical Centre Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Kurahashi, Kiyoyasu" sort="Kurahashi, Kiyoyasu" uniqKey="Kurahashi K" first="Kiyoyasu" last="Kurahashi">Kiyoyasu Kurahashi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, School of Medicine, International University of Health and Welfare, Narita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Anesthesiology and Intensive Care Medicine, School of Medicine, International University of Health and Welfare, Narita</wicri:regionArea></affiliation></author><author><name sortKey="Laake, Jon Henrik" sort="Laake, Jon Henrik" uniqKey="Laake J" first="Jon Henrik" last="Laake">Jon Henrik Laake</name><affiliation wicri:level="1"><nlm:affiliation>Division of Critical Care, Department of Anaesthesiology, Rikshospitalet Medical Centre, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Division of Critical Care, Department of Anaesthesiology, Rikshospitalet Medical Centre, Oslo University Hospital, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Lorente, Jose A" sort="Lorente, Jose A" uniqKey="Lorente J" first="Jose A" last="Lorente">Jose A. Lorente</name><affiliation wicri:level="1"><nlm:affiliation>CIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Universidad Europea, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Mcnamee, Lia" sort="Mcnamee, Lia" uniqKey="Mcnamee L" first="Lia" last="Mcnamee">Lia Mcnamee</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Experimental Medicine, Queen's University of Belfast, Belfast, Northern Ireland, UK; Wellcome-Wolfson Institute for Experimental Medicine, Belfast, Northern Ireland, UK; Regional Intensive Care Unit, Royal Victoria Hospital A&E, Grosvenor Road, Belfast, Northern Ireland, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Experimental Medicine, Queen's University of Belfast, Belfast, Northern Ireland, UK; Wellcome-Wolfson Institute for Experimental Medicine, Belfast, Northern Ireland, UK; Regional Intensive Care Unit, Royal Victoria Hospital A&E, Grosvenor Road, Belfast, Northern Ireland</wicri:regionArea></affiliation></author><author><name sortKey="Nin, Nicolas" sort="Nin, Nicolas" uniqKey="Nin N" first="Nicolas" last="Nin">Nicolas Nin</name><affiliation wicri:level="1"><nlm:affiliation>CIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain; Hospital Español, Montevideo, Uruguay.</nlm:affiliation><country xml:lang="fr">Uruguay</country><wicri:regionArea>CIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain; Hospital Español, Montevideo</wicri:regionArea></affiliation></author><author><name sortKey="Palo, Jose Emmanuel" sort="Palo, Jose Emmanuel" uniqKey="Palo J" first="Jose Emmanuel" last="Palo">Jose Emmanuel Palo</name><affiliation wicri:level="1"><nlm:affiliation>Section of Adult Critical Care, Department of Medicine, The Medical City, Pasig, Philippines.</nlm:affiliation><country xml:lang="fr">Philippines</country><wicri:regionArea>Section of Adult Critical Care, Department of Medicine, The Medical City, Pasig</wicri:regionArea></affiliation></author><author><name sortKey="Piquilloud, Lise" sort="Piquilloud, Lise" uniqKey="Piquilloud L" first="Lise" last="Piquilloud">Lise Piquilloud</name><affiliation wicri:level="1"><nlm:affiliation>Adult Intensive Care and Burn Unit, University Hospital of Lausanne, Lausanne, Switzerland; Department of Medical Intensive Care, University Hospital of Angers, Angers, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Adult Intensive Care and Burn Unit, University Hospital of Lausanne, Lausanne, Switzerland; Department of Medical Intensive Care, University Hospital of Angers, Angers</wicri:regionArea></affiliation></author><author><name sortKey="Qiu, Haibo" sort="Qiu, Haibo" uniqKey="Qiu H" first="Haibo" last="Qiu">Haibo Qiu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Nanjing Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Critical Care Medicine, Nanjing Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009</wicri:regionArea></affiliation></author><author><name sortKey="Jimenez, Juan Ignacio Silesky" sort="Jimenez, Juan Ignacio Silesky" uniqKey="Jimenez J" first="Juan Ignacio Silesky" last="Jiménez">Juan Ignacio Silesky Jiménez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care, Hospital San Juan de Dios, and Department of Intensive Care, Hospital CIMA San Jose, Council of Critical Medicine, University of Costa Rica, San Pedro Montes de Oca, Costa Rica.</nlm:affiliation><country xml:lang="fr">Costa Rica</country><wicri:regionArea>Department of Intensive Care, Hospital San Juan de Dios, and Department of Intensive Care, Hospital CIMA San Jose, Council of Critical Medicine, University of Costa Rica, San Pedro Montes de Oca</wicri:regionArea></affiliation></author><author><name sortKey="Esteban, Andres" sort="Esteban, Andres" uniqKey="Esteban A" first="Andres" last="Esteban">Andres Esteban</name><affiliation wicri:level="1"><nlm:affiliation>CIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain; Hospital Español, Montevideo, Uruguay.</nlm:affiliation><country xml:lang="fr">Uruguay</country><wicri:regionArea>CIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain; Hospital Español, Montevideo</wicri:regionArea></affiliation></author><author><name sortKey="Mcauley, Daniel F" sort="Mcauley, Daniel F" uniqKey="Mcauley D" first="Daniel F" last="Mcauley">Daniel F. Mcauley</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Experimental Medicine, Queen's University of Belfast, Belfast, Northern Ireland, UK; Wellcome-Wolfson Institute for Experimental Medicine, Belfast, Northern Ireland, UK; Regional Intensive Care Unit, Royal Victoria Hospital A&E, Grosvenor Road, Belfast, Northern Ireland, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Experimental Medicine, Queen's University of Belfast, Belfast, Northern Ireland, UK; Wellcome-Wolfson Institute for Experimental Medicine, Belfast, Northern Ireland, UK; Regional Intensive Care Unit, Royal Victoria Hospital A&E, Grosvenor Road, Belfast, Northern Ireland</wicri:regionArea></affiliation></author><author><name sortKey="Van Haren, Frank" sort="Van Haren, Frank" uniqKey="Van Haren F" first="Frank" last="Van Haren">Frank Van Haren</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Unit, Canberra Hospital, Canberra, ACT, Australia; Australian National University, Canberra, ACT, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Intensive Care Unit, Canberra Hospital, Canberra, ACT, Australia; Australian National University, Canberra, ACT</wicri:regionArea></affiliation></author><author><name sortKey="Ranieri, Marco" sort="Ranieri, Marco" uniqKey="Ranieri M" first="Marco" last="Ranieri">Marco Ranieri</name><affiliation wicri:level="1"><nlm:affiliation>Sapienza Università di Roma, Dipartimento di Anestesia e Rianimazione, Policlinico Umberto I, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Sapienza Università di Roma, Dipartimento di Anestesia e Rianimazione, Policlinico Umberto I, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Rubenfeld, Gordon" sort="Rubenfeld, Gordon" uniqKey="Rubenfeld G" first="Gordon" last="Rubenfeld">Gordon Rubenfeld</name><affiliation wicri:level="1"><nlm:affiliation>Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Program in Trauma, Emergency and Critical Care, Sunnybrook Health Sciences Center, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Program in Trauma, Emergency and Critical Care, Sunnybrook Health Sciences Center, Toronto, ON</wicri:regionArea></affiliation></author><author><name sortKey="Wrigge, Hermann" sort="Wrigge, Hermann" uniqKey="Wrigge H" first="Hermann" last="Wrigge">Hermann Wrigge</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, University of Leipzig, Leipzig, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anesthesiology and Intensive Care Medicine, University of Leipzig, Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="Slutsky, Arthur S" sort="Slutsky, Arthur S" uniqKey="Slutsky A" first="Arthur S" last="Slutsky">Arthur S. Slutsky</name><affiliation wicri:level="1"><nlm:affiliation>Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON</wicri:regionArea></affiliation></author><author><name sortKey="Pesenti, Antonio" sort="Pesenti, Antonio" uniqKey="Pesenti A" first="Antonio" last="Pesenti">Antonio Pesenti</name><affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Anestesia, Rianimazione ed Emergenza Urgenza, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico and Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Anestesia, Rianimazione ed Emergenza Urgenza, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico and Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28624388</idno><idno type="pmid">28624388</idno><idno type="doi">10.1016/S2213-2600(17)30213-8</idno><idno type="wicri:Area/PubMed/Corpus">000826</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000826</idno><idno type="wicri:Area/PubMed/Curation">000823</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000823</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study.</title><author><name sortKey="Laffey, John G" sort="Laffey, John G" uniqKey="Laffey J" first="John G" last="Laffey">John G. Laffey</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesia, St Michael's Hospital, Toronto, ON, Canada; Department of Critical Care Medicine, St Michael's Hospital, Toronto, ON, Canada; Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Department of Anesthesia, University of Toronto, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada. Electronic address: laffeyj@smh.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anesthesia, St Michael's Hospital, Toronto, ON, Canada; Department of Critical Care Medicine, St Michael's Hospital, Toronto, ON, Canada; Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Department of Anesthesia, University of Toronto, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON</wicri:regionArea></affiliation></author><author><name sortKey="Madotto, Fabiana" sort="Madotto, Fabiana" uniqKey="Madotto F" first="Fabiana" last="Madotto">Fabiana Madotto</name><affiliation wicri:level="1"><nlm:affiliation>Research Center on Public Health, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Research Center on Public Health, Department of Medicine and Surgery, University of Milano-Bicocca, Monza</wicri:regionArea></affiliation></author><author><name sortKey="Bellani, Giacomo" sort="Bellani, Giacomo" uniqKey="Bellani G" first="Giacomo" last="Bellani">Giacomo Bellani</name><affiliation wicri:level="1"><nlm:affiliation>Research Center on Public Health, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; Department of Emergency and Intensive Care, San Gerardo Hospital, Monza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Research Center on Public Health, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; Department of Emergency and Intensive Care, San Gerardo Hospital, Monza</wicri:regionArea></affiliation></author><author><name sortKey="Pham, Tai" sort="Pham, Tai" uniqKey="Pham T" first="Tài" last="Pham">Tài Pham</name><affiliation wicri:level="1"><nlm:affiliation>Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Sorbonne Universités, UPMC Université Paris 06, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Sorbonne Universités, UPMC Université Paris 06, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Fan, Eddy" sort="Fan, Eddy" uniqKey="Fan E" first="Eddy" last="Fan">Eddy Fan</name><affiliation wicri:level="1"><nlm:affiliation>Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; Department of Medicine, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; Department of Medicine, University Health Network and Mount Sinai Hospital, Toronto, ON</wicri:regionArea></affiliation></author><author><name sortKey="Brochard, Laurent" sort="Brochard, Laurent" uniqKey="Brochard L" first="Laurent" last="Brochard">Laurent Brochard</name><affiliation wicri:level="1"><nlm:affiliation>Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON</wicri:regionArea></affiliation></author><author><name sortKey="Amin, Pravin" sort="Amin, Pravin" uniqKey="Amin P" first="Pravin" last="Amin">Pravin Amin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Bombay Hospital Institute of Medical Sciences, Mumbai, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Critical Care Medicine, Bombay Hospital Institute of Medical Sciences, Mumbai</wicri:regionArea></affiliation></author><author><name sortKey="Arabi, Yaseen" sort="Arabi, Yaseen" uniqKey="Arabi Y" first="Yaseen" last="Arabi">Yaseen Arabi</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; Respiratory Services, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; Respiratory Services, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh</wicri:regionArea></affiliation></author><author><name sortKey="Bajwa, Ednan K" sort="Bajwa, Ednan K" uniqKey="Bajwa E" first="Ednan K" last="Bajwa">Ednan K. Bajwa</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pulmonary and Critical Care, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary and Critical Care, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Bruhn, Alejandro" sort="Bruhn, Alejandro" uniqKey="Bruhn A" first="Alejandro" last="Bruhn">Alejandro Bruhn</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago</wicri:regionArea></affiliation></author><author><name sortKey="Cerny, Vladimir" sort="Cerny, Vladimir" uniqKey="Cerny V" first="Vladimir" last="Cerny">Vladimir Cerny</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology, Perioperative Medicine and Intensive Care, J E Purkinje University, Masaryk Hospital, Usti nad Labem, Czech Republic; Department of Research and Development, and Department of Anesthesiology and Intensive Care, Charles University in Prague, Prague, Czech Republic; Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Anesthesiology, Perioperative Medicine and Intensive Care, J E Purkinje University, Masaryk Hospital, Usti nad Labem, Czech Republic; Department of Research and Development, and Department of Anesthesiology and Intensive Care, Charles University in Prague, Prague, Czech Republic; Faculty of Medicine in Hradec Kralove, Hradec Kralove</wicri:regionArea></affiliation></author><author><name sortKey="Clarkson, Kevin" sort="Clarkson, Kevin" uniqKey="Clarkson K" first="Kevin" last="Clarkson">Kevin Clarkson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anaesthesia, Galway University Hospitals and National University of Ireland, Galway, Galway, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Anaesthesia, Galway University Hospitals and National University of Ireland, Galway, Galway</wicri:regionArea></affiliation></author><author><name sortKey="Heunks, Leo" sort="Heunks, Leo" uniqKey="Heunks L" first="Leo" last="Heunks">Leo Heunks</name><affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care, VU University Medical Centre Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Intensive Care, VU University Medical Centre Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Kurahashi, Kiyoyasu" sort="Kurahashi, Kiyoyasu" uniqKey="Kurahashi K" first="Kiyoyasu" last="Kurahashi">Kiyoyasu Kurahashi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, School of Medicine, International University of Health and Welfare, Narita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Anesthesiology and Intensive Care Medicine, School of Medicine, International University of Health and Welfare, Narita</wicri:regionArea></affiliation></author><author><name sortKey="Laake, Jon Henrik" sort="Laake, Jon Henrik" uniqKey="Laake J" first="Jon Henrik" last="Laake">Jon Henrik Laake</name><affiliation wicri:level="1"><nlm:affiliation>Division of Critical Care, Department of Anaesthesiology, Rikshospitalet Medical Centre, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Division of Critical Care, Department of Anaesthesiology, Rikshospitalet Medical Centre, Oslo University Hospital, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Lorente, Jose A" sort="Lorente, Jose A" uniqKey="Lorente J" first="Jose A" last="Lorente">Jose A. Lorente</name><affiliation wicri:level="1"><nlm:affiliation>CIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Universidad Europea, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Mcnamee, Lia" sort="Mcnamee, Lia" uniqKey="Mcnamee L" first="Lia" last="Mcnamee">Lia Mcnamee</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Experimental Medicine, Queen's University of Belfast, Belfast, Northern Ireland, UK; Wellcome-Wolfson Institute for Experimental Medicine, Belfast, Northern Ireland, UK; Regional Intensive Care Unit, Royal Victoria Hospital A&E, Grosvenor Road, Belfast, Northern Ireland, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Experimental Medicine, Queen's University of Belfast, Belfast, Northern Ireland, UK; Wellcome-Wolfson Institute for Experimental Medicine, Belfast, Northern Ireland, UK; Regional Intensive Care Unit, Royal Victoria Hospital A&E, Grosvenor Road, Belfast, Northern Ireland</wicri:regionArea></affiliation></author><author><name sortKey="Nin, Nicolas" sort="Nin, Nicolas" uniqKey="Nin N" first="Nicolas" last="Nin">Nicolas Nin</name><affiliation wicri:level="1"><nlm:affiliation>CIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain; Hospital Español, Montevideo, Uruguay.</nlm:affiliation><country xml:lang="fr">Uruguay</country><wicri:regionArea>CIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain; Hospital Español, Montevideo</wicri:regionArea></affiliation></author><author><name sortKey="Palo, Jose Emmanuel" sort="Palo, Jose Emmanuel" uniqKey="Palo J" first="Jose Emmanuel" last="Palo">Jose Emmanuel Palo</name><affiliation wicri:level="1"><nlm:affiliation>Section of Adult Critical Care, Department of Medicine, The Medical City, Pasig, Philippines.</nlm:affiliation><country xml:lang="fr">Philippines</country><wicri:regionArea>Section of Adult Critical Care, Department of Medicine, The Medical City, Pasig</wicri:regionArea></affiliation></author><author><name sortKey="Piquilloud, Lise" sort="Piquilloud, Lise" uniqKey="Piquilloud L" first="Lise" last="Piquilloud">Lise Piquilloud</name><affiliation wicri:level="1"><nlm:affiliation>Adult Intensive Care and Burn Unit, University Hospital of Lausanne, Lausanne, Switzerland; Department of Medical Intensive Care, University Hospital of Angers, Angers, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Adult Intensive Care and Burn Unit, University Hospital of Lausanne, Lausanne, Switzerland; Department of Medical Intensive Care, University Hospital of Angers, Angers</wicri:regionArea></affiliation></author><author><name sortKey="Qiu, Haibo" sort="Qiu, Haibo" uniqKey="Qiu H" first="Haibo" last="Qiu">Haibo Qiu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Nanjing Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Critical Care Medicine, Nanjing Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009</wicri:regionArea></affiliation></author><author><name sortKey="Jimenez, Juan Ignacio Silesky" sort="Jimenez, Juan Ignacio Silesky" uniqKey="Jimenez J" first="Juan Ignacio Silesky" last="Jiménez">Juan Ignacio Silesky Jiménez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care, Hospital San Juan de Dios, and Department of Intensive Care, Hospital CIMA San Jose, Council of Critical Medicine, University of Costa Rica, San Pedro Montes de Oca, Costa Rica.</nlm:affiliation><country xml:lang="fr">Costa Rica</country><wicri:regionArea>Department of Intensive Care, Hospital San Juan de Dios, and Department of Intensive Care, Hospital CIMA San Jose, Council of Critical Medicine, University of Costa Rica, San Pedro Montes de Oca</wicri:regionArea></affiliation></author><author><name sortKey="Esteban, Andres" sort="Esteban, Andres" uniqKey="Esteban A" first="Andres" last="Esteban">Andres Esteban</name><affiliation wicri:level="1"><nlm:affiliation>CIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain; Hospital Español, Montevideo, Uruguay.</nlm:affiliation><country xml:lang="fr">Uruguay</country><wicri:regionArea>CIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain; Hospital Español, Montevideo</wicri:regionArea></affiliation></author><author><name sortKey="Mcauley, Daniel F" sort="Mcauley, Daniel F" uniqKey="Mcauley D" first="Daniel F" last="Mcauley">Daniel F. Mcauley</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Experimental Medicine, Queen's University of Belfast, Belfast, Northern Ireland, UK; Wellcome-Wolfson Institute for Experimental Medicine, Belfast, Northern Ireland, UK; Regional Intensive Care Unit, Royal Victoria Hospital A&E, Grosvenor Road, Belfast, Northern Ireland, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Experimental Medicine, Queen's University of Belfast, Belfast, Northern Ireland, UK; Wellcome-Wolfson Institute for Experimental Medicine, Belfast, Northern Ireland, UK; Regional Intensive Care Unit, Royal Victoria Hospital A&E, Grosvenor Road, Belfast, Northern Ireland</wicri:regionArea></affiliation></author><author><name sortKey="Van Haren, Frank" sort="Van Haren, Frank" uniqKey="Van Haren F" first="Frank" last="Van Haren">Frank Van Haren</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Unit, Canberra Hospital, Canberra, ACT, Australia; Australian National University, Canberra, ACT, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Intensive Care Unit, Canberra Hospital, Canberra, ACT, Australia; Australian National University, Canberra, ACT</wicri:regionArea></affiliation></author><author><name sortKey="Ranieri, Marco" sort="Ranieri, Marco" uniqKey="Ranieri M" first="Marco" last="Ranieri">Marco Ranieri</name><affiliation wicri:level="1"><nlm:affiliation>Sapienza Università di Roma, Dipartimento di Anestesia e Rianimazione, Policlinico Umberto I, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Sapienza Università di Roma, Dipartimento di Anestesia e Rianimazione, Policlinico Umberto I, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Rubenfeld, Gordon" sort="Rubenfeld, Gordon" uniqKey="Rubenfeld G" first="Gordon" last="Rubenfeld">Gordon Rubenfeld</name><affiliation wicri:level="1"><nlm:affiliation>Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Program in Trauma, Emergency and Critical Care, Sunnybrook Health Sciences Center, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Program in Trauma, Emergency and Critical Care, Sunnybrook Health Sciences Center, Toronto, ON</wicri:regionArea></affiliation></author><author><name sortKey="Wrigge, Hermann" sort="Wrigge, Hermann" uniqKey="Wrigge H" first="Hermann" last="Wrigge">Hermann Wrigge</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, University of Leipzig, Leipzig, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anesthesiology and Intensive Care Medicine, University of Leipzig, Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="Slutsky, Arthur S" sort="Slutsky, Arthur S" uniqKey="Slutsky A" first="Arthur S" last="Slutsky">Arthur S. Slutsky</name><affiliation wicri:level="1"><nlm:affiliation>Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON</wicri:regionArea></affiliation></author><author><name sortKey="Pesenti, Antonio" sort="Pesenti, Antonio" uniqKey="Pesenti A" first="Antonio" last="Pesenti">Antonio Pesenti</name><affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Anestesia, Rianimazione ed Emergenza Urgenza, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico and Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Anestesia, Rianimazione ed Emergenza Urgenza, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico and Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Lancet. Respiratory medicine</title><idno type="eISSN">2213-2619</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Little information is available about the geo-economic variations in demographics, management, and outcomes of patients with acute respiratory distress syndrome (ARDS). We aimed to characterise the effect of these geo-economic variations in patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE).</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28624388</PMID><DateCreated><Year>2017</Year><Month>06</Month><Day>18</Day></DateCreated><DateRevised><Year>2017</Year><Month>07</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2213-2619</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>8</Issue><PubDate><Year>2017</Year><Month>Aug</Month></PubDate></JournalIssue><Title>The Lancet. Respiratory medicine</Title><ISOAbbreviation>Lancet Respir Med</ISOAbbreviation></Journal><ArticleTitle>Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study.</ArticleTitle><Pagination><MedlinePgn>627-638</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S2213-2600(17)30213-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/S2213-2600(17)30213-8</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Little information is available about the geo-economic variations in demographics, management, and outcomes of patients with acute respiratory distress syndrome (ARDS). We aimed to characterise the effect of these geo-economic variations in patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">LUNG SAFE was done during 4 consecutive weeks in winter, 2014, in a convenience sample of 459 intensive-care units in 50 countries across six continents. Inclusion criteria were admission to a participating intensive-care unit (including transfers) within the enrolment window and receipt of invasive or non-invasive ventilation. One of the trial's secondary aims was to characterise variations in the demographics, management, and outcome of patients with ARDS. We used the 2016 World Bank countries classification to define three major geo-economic groupings, namely European high-income countries (Europe-High), high-income countries in the rest of the world (rWORLD-High), and middle-income countries (Middle). We compared patient outcomes across these three groupings. LUNG SAFE is registered with ClinicalTrials.gov, number NCT02010073.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">Of the 2813 patients enrolled in LUNG SAFE who fulfilled ARDS criteria on day 1 or 2, 1521 (54%) were recruited from Europe-High, 746 (27%) from rWORLD-High, and 546 (19%) from Middle countries. We noted significant geographical variations in demographics, risk factors for ARDS, and comorbid diseases. The proportion of patients with severe ARDS or with ratios of the partial pressure of arterial oxygen (PaO2) to the fractional concentration of oxygen in inspired air (FiO2) less than 150 was significantly lower in rWORLD-High countries than in the two other regions. Use of prone positioning and neuromuscular blockade was significantly more common in Europe-High countries than in the other two regions. Adjusted duration of invasive mechanical ventilation and length of stay in the intensive-care unit were significantly shorter in patients in rWORLD-High countries than in Europe-High or Middle countries. High gross national income per person was associated with increased survival in ARDS; hospital survival was significantly lower in Middle countries than in Europe-High or rWORLD-High countries.</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Important geo-economic differences exist in the severity, clinician recognition, and management of ARDS, and in patients' outcomes. Income per person and outcomes in ARDS are independently associated.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">European Society of Intensive Care Medicine, St Michael's Hospital, University of Milan-Bicocca.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Laffey</LastName><ForeName>John G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Department of Anesthesia, St Michael's Hospital, Toronto, ON, Canada; Department of Critical Care Medicine, St Michael's Hospital, Toronto, ON, Canada; Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Department of Anesthesia, University of Toronto, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada. Electronic address: laffeyj@smh.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Madotto</LastName><ForeName>Fabiana</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Research Center on Public Health, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bellani</LastName><ForeName>Giacomo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Research Center on Public Health, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; Department of Emergency and Intensive Care, San Gerardo Hospital, Monza, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pham</LastName><ForeName>Tài</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Sorbonne Universités, UPMC Université Paris 06, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fan</LastName><ForeName>Eddy</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; Department of Medicine, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brochard</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amin</LastName><ForeName>Pravin</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Critical Care Medicine, Bombay Hospital Institute of Medical Sciences, Mumbai, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arabi</LastName><ForeName>Yaseen</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Intensive Care Department, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; Respiratory Services, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bajwa</LastName><ForeName>Ednan K</ForeName><Initials>EK</Initials><AffiliationInfo><Affiliation>Division of Pulmonary and Critical Care, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bruhn</LastName><ForeName>Alejandro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cerny</LastName><ForeName>Vladimir</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology, Perioperative Medicine and Intensive Care, J E Purkinje University, Masaryk Hospital, Usti nad Labem, Czech Republic; Department of Research and Development, and Department of Anesthesiology and Intensive Care, Charles University in Prague, Prague, Czech Republic; Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clarkson</LastName><ForeName>Kevin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Anaesthesia, Galway University Hospitals and National University of Ireland, Galway, Galway, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heunks</LastName><ForeName>Leo</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Intensive Care, VU University Medical Centre Amsterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kurahashi</LastName><ForeName>Kiyoyasu</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology and Intensive Care Medicine, School of Medicine, International University of Health and Welfare, Narita, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laake</LastName><ForeName>Jon Henrik</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Division of Critical Care, Department of Anaesthesiology, Rikshospitalet Medical Centre, Oslo University Hospital, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lorente</LastName><ForeName>Jose A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>CIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McNamee</LastName><ForeName>Lia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Centre for Experimental Medicine, Queen's University of Belfast, Belfast, Northern Ireland, UK; Wellcome-Wolfson Institute for Experimental Medicine, Belfast, Northern Ireland, UK; Regional Intensive Care Unit, Royal Victoria Hospital A&E, Grosvenor Road, Belfast, Northern Ireland, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nin</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>CIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain; Hospital Español, Montevideo, Uruguay.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palo</LastName><ForeName>Jose Emmanuel</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Section of Adult Critical Care, Department of Medicine, The Medical City, Pasig, Philippines.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Piquilloud</LastName><ForeName>Lise</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Adult Intensive Care and Burn Unit, University Hospital of Lausanne, Lausanne, Switzerland; Department of Medical Intensive Care, University Hospital of Angers, Angers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qiu</LastName><ForeName>Haibo</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Critical Care Medicine, Nanjing Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiménez</LastName><ForeName>Juan Ignacio Silesky</ForeName><Initials>JIS</Initials><AffiliationInfo><Affiliation>Department of Intensive Care, Hospital San Juan de Dios, and Department of Intensive Care, Hospital CIMA San Jose, Council of Critical Medicine, University of Costa Rica, San Pedro Montes de Oca, Costa Rica.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Esteban</LastName><ForeName>Andres</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>CIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain; Hospital Español, Montevideo, Uruguay.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McAuley</LastName><ForeName>Daniel F</ForeName><Initials>DF</Initials><AffiliationInfo><Affiliation>Centre for Experimental Medicine, Queen's University of Belfast, Belfast, Northern Ireland, UK; Wellcome-Wolfson Institute for Experimental Medicine, Belfast, Northern Ireland, UK; Regional Intensive Care Unit, Royal Victoria Hospital A&E, Grosvenor Road, Belfast, Northern Ireland, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Haren</LastName><ForeName>Frank</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Intensive Care Unit, Canberra Hospital, Canberra, ACT, Australia; Australian National University, Canberra, ACT, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ranieri</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Sapienza Università di Roma, Dipartimento di Anestesia e Rianimazione, Policlinico Umberto I, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rubenfeld</LastName><ForeName>Gordon</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Program in Trauma, Emergency and Critical Care, Sunnybrook Health Sciences Center, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wrigge</LastName><ForeName>Hermann</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology and Intensive Care Medicine, University of Leipzig, Leipzig, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slutsky</LastName><ForeName>Arthur S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pesenti</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Dipartimento di Anestesia, Rianimazione ed Emergenza Urgenza, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico and Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>LUNG SAFE Investigators and the ESICM Trials Group</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>06</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lancet Respir Med</MedlineTA><NlmUniqueID>101605555</NlmUniqueID><ISSNLinking>2213-2600</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>12</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>04</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>04</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>6</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>6</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28624388</ArticleId><ArticleId IdType="pii">S2213-2600(17)30213-8</ArticleId><ArticleId IdType="doi">10.1016/S2213-2600(17)30213-8</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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