The extent of B-cell activation and dysfunction preceding lymphoma development in HIV-positive people.
Identifieur interne : 000765 ( PubMed/Curation ); précédent : 000764; suivant : 000766The extent of B-cell activation and dysfunction preceding lymphoma development in HIV-positive people.
Auteurs : L. Shepherd [Royaume-Uni] ; Á H. Borges [Danemark] ; R. Harvey [Royaume-Uni] ; M. Bower [Royaume-Uni] ; A. Grulich [Australie] ; M. Silverberg [États-Unis] ; J. Weber [Royaume-Uni] ; M. Ristola [Finlande] ; J-P Viard [France] ; J R Bogner [Allemagne] ; P. Gargalianos-Kakolyris [Grèce] ; C. Mussini [Italie] ; K. Mansinho [Portugal] ; I. Yust [Israël] ; D. Paduta [Biélorussie] ; D. Jilich [République tchèque] ; T. Smiatacz [Pologne] ; R. Radoi [Roumanie] ; J. Tomazic [Slovénie] ; P. Plomgaard [Danemark] ; R. Frikke-Schmidt [Danemark] ; J. Lundgren [Danemark] ; A. Mocroft [Royaume-Uni]Source :
- HIV medicine [ 1468-1293 ] ; 2017.
Abstract
B-cell dysfunction and activation are thought to contribute to lymphoma development in HIV-positive people; however, the mechanisms are not well understood. We investigated levels of several markers of B-cell dysfunction [free light chain (FLC)-κ, FLC-λ, immunoglobulin G (IgG), IgA, IgM and IgD] prior to lymphoma diagnosis in HIV-positive people.
DOI: 10.1111/hiv.12546
PubMed: 28857427
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The extent of B-cell activation and dysfunction preceding lymphoma development in HIV-positive people.</title><author><name sortKey="Shepherd, L" sort="Shepherd, L" uniqKey="Shepherd L" first="L" last="Shepherd">L. Shepherd</name><affiliation wicri:level="1"><nlm:affiliation>Research Department of Infection and Population Health, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Department of Infection and Population Health, University College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Borges, A H" sort="Borges, A H" uniqKey="Borges A" first="Á H" last="Borges">Á H. Borges</name><affiliation wicri:level="1"><nlm:affiliation>Centre of Excellence for Health, Immunity and Infections, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Centre of Excellence for Health, Immunity and Infections, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Harvey, R" sort="Harvey, R" uniqKey="Harvey R" first="R" last="Harvey">R. Harvey</name><affiliation wicri:level="1"><nlm:affiliation>Charing Cross Oncology Laboratory and Trophoblastic Disease Centre, Charing Cross Hospital Campus of Imperial College Healthcare National Health Service Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Charing Cross Oncology Laboratory and Trophoblastic Disease Centre, Charing Cross Hospital Campus of Imperial College Healthcare National Health Service Trust, London</wicri:regionArea></affiliation></author><author><name sortKey="Bower, M" sort="Bower, M" uniqKey="Bower M" first="M" last="Bower">M. Bower</name><affiliation wicri:level="1"><nlm:affiliation>National Centre for HIV Malignancy, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Centre for HIV Malignancy, Chelsea and Westminster Hospital NHS Foundation Trust, London</wicri:regionArea></affiliation></author><author><name sortKey="Grulich, A" sort="Grulich, A" uniqKey="Grulich A" first="A" last="Grulich">A. Grulich</name><affiliation wicri:level="1"><nlm:affiliation>Kirby Institute, The University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Kirby Institute, The University of New South Wales, Sydney, NSW</wicri:regionArea></affiliation></author><author><name sortKey="Silverberg, M" sort="Silverberg, M" uniqKey="Silverberg M" first="M" last="Silverberg">M. Silverberg</name><affiliation wicri:level="1"><nlm:affiliation>Kaiser Permanente Northern California, Oakland, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Kaiser Permanente Northern California, Oakland, CA</wicri:regionArea></affiliation></author><author><name sortKey="Weber, J" sort="Weber, J" uniqKey="Weber J" first="J" last="Weber">J. Weber</name><affiliation wicri:level="1"><nlm:affiliation>Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Ristola, M" sort="Ristola, M" uniqKey="Ristola M" first="M" last="Ristola">M. Ristola</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Division of Infectious Diseases, University of Helsinki and Helsinki University Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Viard, J P" sort="Viard, J P" uniqKey="Viard J" first="J-P" last="Viard">J-P Viard</name><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Diagnostic & Therapeutic Center, Hotel Dieu Hospital, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Diagnostic & Therapeutic Center, Hotel Dieu Hospital, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Bogner, J R" sort="Bogner, J R" uniqKey="Bogner J" first="J R" last="Bogner">J R Bogner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine IV, University of Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine IV, University of Munich, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Gargalianos Kakolyris, P" sort="Gargalianos Kakolyris, P" uniqKey="Gargalianos Kakolyris P" first="P" last="Gargalianos-Kakolyris">P. Gargalianos-Kakolyris</name><affiliation wicri:level="1"><nlm:affiliation>First Department of Internal Medicine and Infectious Diseases Unit, General Hospital of Athens "G. Gennimatas", Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>First Department of Internal Medicine and Infectious Diseases Unit, General Hospital of Athens "G. Gennimatas", Athens</wicri:regionArea></affiliation></author><author><name sortKey="Mussini, C" sort="Mussini, C" uniqKey="Mussini C" first="C" last="Mussini">C. Mussini</name><affiliation wicri:level="1"><nlm:affiliation>Clinic of Infectious and Tropical Diseases, University of Modena and Reggio Emilia, Azienda Policlinico, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinic of Infectious and Tropical Diseases, University of Modena and Reggio Emilia, Azienda Policlinico, Modena</wicri:regionArea></affiliation></author><author><name sortKey="Mansinho, K" sort="Mansinho, K" uniqKey="Mansinho K" first="K" last="Mansinho">K. Mansinho</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Hospital Egas Moniz-CHLO, E.P.E., Lisboa, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Infectious Diseases, Hospital Egas Moniz-CHLO, E.P.E., Lisboa</wicri:regionArea></affiliation></author><author><name sortKey="Yust, I" sort="Yust, I" uniqKey="Yust I" first="I" last="Yust">I. Yust</name><affiliation wicri:level="1"><nlm:affiliation>Ichilov Hospital, Tel Aviv, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Ichilov Hospital, Tel Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Paduta, D" sort="Paduta, D" uniqKey="Paduta D" first="D" last="Paduta">D. Paduta</name><affiliation wicri:level="1"><nlm:affiliation>Gomel Regional Centre for Hygiene, Gomel, Belarus.</nlm:affiliation><country xml:lang="fr">Biélorussie</country><wicri:regionArea>Gomel Regional Centre for Hygiene, Gomel</wicri:regionArea></affiliation></author><author><name sortKey="Jilich, D" sort="Jilich, D" uniqKey="Jilich D" first="D" last="Jilich">D. Jilich</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University, Prague</wicri:regionArea></affiliation></author><author><name sortKey="Smiatacz, T" sort="Smiatacz, T" uniqKey="Smiatacz T" first="T" last="Smiatacz">T. Smiatacz</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Diseases Department, Medical University of Gdańsk, Gdańsk, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Infectious Diseases Department, Medical University of Gdańsk, Gdańsk</wicri:regionArea></affiliation></author><author><name sortKey="Radoi, R" sort="Radoi, R" uniqKey="Radoi R" first="R" last="Radoi">R. Radoi</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Hospital of Infectious and Tropical Diseases 'Dr. Victor Babeş', Bucharest, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Clinical Hospital of Infectious and Tropical Diseases 'Dr. Victor Babeş', Bucharest</wicri:regionArea></affiliation></author><author><name sortKey="Tomazic, J" sort="Tomazic, J" uniqKey="Tomazic J" first="J" last="Tomazic">J. Tomazic</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia.</nlm:affiliation><country xml:lang="fr">Slovénie</country><wicri:regionArea>Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana</wicri:regionArea></affiliation></author><author><name sortKey="Plomgaard, P" sort="Plomgaard, P" uniqKey="Plomgaard P" first="P" last="Plomgaard">P. Plomgaard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Frikke Schmidt, R" sort="Frikke Schmidt, R" uniqKey="Frikke Schmidt R" first="R" last="Frikke-Schmidt">R. Frikke-Schmidt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Lundgren, J" sort="Lundgren, J" uniqKey="Lundgren J" first="J" last="Lundgren">J. Lundgren</name><affiliation wicri:level="1"><nlm:affiliation>Centre of Excellence for Health, Immunity and Infections, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Centre of Excellence for Health, Immunity and Infections, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Mocroft, A" sort="Mocroft, A" uniqKey="Mocroft A" first="A" last="Mocroft">A. Mocroft</name><affiliation wicri:level="1"><nlm:affiliation>Research Department of Infection and Population Health, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Department of Infection and Population Health, University College London, London</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28857427</idno><idno type="pmid">28857427</idno><idno type="doi">10.1111/hiv.12546</idno><idno type="wicri:Area/PubMed/Corpus">000768</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000768</idno><idno type="wicri:Area/PubMed/Curation">000765</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000765</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The extent of B-cell activation and dysfunction preceding lymphoma development in HIV-positive people.</title><author><name sortKey="Shepherd, L" sort="Shepherd, L" uniqKey="Shepherd L" first="L" last="Shepherd">L. Shepherd</name><affiliation wicri:level="1"><nlm:affiliation>Research Department of Infection and Population Health, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Department of Infection and Population Health, University College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Borges, A H" sort="Borges, A H" uniqKey="Borges A" first="Á H" last="Borges">Á H. Borges</name><affiliation wicri:level="1"><nlm:affiliation>Centre of Excellence for Health, Immunity and Infections, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Centre of Excellence for Health, Immunity and Infections, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Harvey, R" sort="Harvey, R" uniqKey="Harvey R" first="R" last="Harvey">R. Harvey</name><affiliation wicri:level="1"><nlm:affiliation>Charing Cross Oncology Laboratory and Trophoblastic Disease Centre, Charing Cross Hospital Campus of Imperial College Healthcare National Health Service Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Charing Cross Oncology Laboratory and Trophoblastic Disease Centre, Charing Cross Hospital Campus of Imperial College Healthcare National Health Service Trust, London</wicri:regionArea></affiliation></author><author><name sortKey="Bower, M" sort="Bower, M" uniqKey="Bower M" first="M" last="Bower">M. Bower</name><affiliation wicri:level="1"><nlm:affiliation>National Centre for HIV Malignancy, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Centre for HIV Malignancy, Chelsea and Westminster Hospital NHS Foundation Trust, London</wicri:regionArea></affiliation></author><author><name sortKey="Grulich, A" sort="Grulich, A" uniqKey="Grulich A" first="A" last="Grulich">A. Grulich</name><affiliation wicri:level="1"><nlm:affiliation>Kirby Institute, The University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Kirby Institute, The University of New South Wales, Sydney, NSW</wicri:regionArea></affiliation></author><author><name sortKey="Silverberg, M" sort="Silverberg, M" uniqKey="Silverberg M" first="M" last="Silverberg">M. Silverberg</name><affiliation wicri:level="1"><nlm:affiliation>Kaiser Permanente Northern California, Oakland, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Kaiser Permanente Northern California, Oakland, CA</wicri:regionArea></affiliation></author><author><name sortKey="Weber, J" sort="Weber, J" uniqKey="Weber J" first="J" last="Weber">J. Weber</name><affiliation wicri:level="1"><nlm:affiliation>Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Ristola, M" sort="Ristola, M" uniqKey="Ristola M" first="M" last="Ristola">M. Ristola</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Division of Infectious Diseases, University of Helsinki and Helsinki University Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Viard, J P" sort="Viard, J P" uniqKey="Viard J" first="J-P" last="Viard">J-P Viard</name><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Diagnostic & Therapeutic Center, Hotel Dieu Hospital, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Diagnostic & Therapeutic Center, Hotel Dieu Hospital, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Bogner, J R" sort="Bogner, J R" uniqKey="Bogner J" first="J R" last="Bogner">J R Bogner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine IV, University of Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine IV, University of Munich, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Gargalianos Kakolyris, P" sort="Gargalianos Kakolyris, P" uniqKey="Gargalianos Kakolyris P" first="P" last="Gargalianos-Kakolyris">P. Gargalianos-Kakolyris</name><affiliation wicri:level="1"><nlm:affiliation>First Department of Internal Medicine and Infectious Diseases Unit, General Hospital of Athens "G. Gennimatas", Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>First Department of Internal Medicine and Infectious Diseases Unit, General Hospital of Athens "G. Gennimatas", Athens</wicri:regionArea></affiliation></author><author><name sortKey="Mussini, C" sort="Mussini, C" uniqKey="Mussini C" first="C" last="Mussini">C. Mussini</name><affiliation wicri:level="1"><nlm:affiliation>Clinic of Infectious and Tropical Diseases, University of Modena and Reggio Emilia, Azienda Policlinico, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinic of Infectious and Tropical Diseases, University of Modena and Reggio Emilia, Azienda Policlinico, Modena</wicri:regionArea></affiliation></author><author><name sortKey="Mansinho, K" sort="Mansinho, K" uniqKey="Mansinho K" first="K" last="Mansinho">K. Mansinho</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Hospital Egas Moniz-CHLO, E.P.E., Lisboa, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Infectious Diseases, Hospital Egas Moniz-CHLO, E.P.E., Lisboa</wicri:regionArea></affiliation></author><author><name sortKey="Yust, I" sort="Yust, I" uniqKey="Yust I" first="I" last="Yust">I. Yust</name><affiliation wicri:level="1"><nlm:affiliation>Ichilov Hospital, Tel Aviv, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Ichilov Hospital, Tel Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Paduta, D" sort="Paduta, D" uniqKey="Paduta D" first="D" last="Paduta">D. Paduta</name><affiliation wicri:level="1"><nlm:affiliation>Gomel Regional Centre for Hygiene, Gomel, Belarus.</nlm:affiliation><country xml:lang="fr">Biélorussie</country><wicri:regionArea>Gomel Regional Centre for Hygiene, Gomel</wicri:regionArea></affiliation></author><author><name sortKey="Jilich, D" sort="Jilich, D" uniqKey="Jilich D" first="D" last="Jilich">D. Jilich</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University, Prague</wicri:regionArea></affiliation></author><author><name sortKey="Smiatacz, T" sort="Smiatacz, T" uniqKey="Smiatacz T" first="T" last="Smiatacz">T. Smiatacz</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Diseases Department, Medical University of Gdańsk, Gdańsk, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Infectious Diseases Department, Medical University of Gdańsk, Gdańsk</wicri:regionArea></affiliation></author><author><name sortKey="Radoi, R" sort="Radoi, R" uniqKey="Radoi R" first="R" last="Radoi">R. Radoi</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Hospital of Infectious and Tropical Diseases 'Dr. Victor Babeş', Bucharest, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Clinical Hospital of Infectious and Tropical Diseases 'Dr. Victor Babeş', Bucharest</wicri:regionArea></affiliation></author><author><name sortKey="Tomazic, J" sort="Tomazic, J" uniqKey="Tomazic J" first="J" last="Tomazic">J. Tomazic</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia.</nlm:affiliation><country xml:lang="fr">Slovénie</country><wicri:regionArea>Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana</wicri:regionArea></affiliation></author><author><name sortKey="Plomgaard, P" sort="Plomgaard, P" uniqKey="Plomgaard P" first="P" last="Plomgaard">P. Plomgaard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Frikke Schmidt, R" sort="Frikke Schmidt, R" uniqKey="Frikke Schmidt R" first="R" last="Frikke-Schmidt">R. Frikke-Schmidt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Lundgren, J" sort="Lundgren, J" uniqKey="Lundgren J" first="J" last="Lundgren">J. Lundgren</name><affiliation wicri:level="1"><nlm:affiliation>Centre of Excellence for Health, Immunity and Infections, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Centre of Excellence for Health, Immunity and Infections, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Mocroft, A" sort="Mocroft, A" uniqKey="Mocroft A" first="A" last="Mocroft">A. Mocroft</name><affiliation wicri:level="1"><nlm:affiliation>Research Department of Infection and Population Health, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Department of Infection and Population Health, University College London, London</wicri:regionArea></affiliation></author></analytic><series><title level="j">HIV medicine</title><idno type="eISSN">1468-1293</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">B-cell dysfunction and activation are thought to contribute to lymphoma development in HIV-positive people; however, the mechanisms are not well understood. We investigated levels of several markers of B-cell dysfunction [free light chain (FLC)-κ, FLC-λ, immunoglobulin G (IgG), IgA, IgM and IgD] prior to lymphoma diagnosis in HIV-positive people.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">28857427</PMID><DateCreated><Year>2017</Year><Month>08</Month><Day>31</Day></DateCreated><DateRevised><Year>2017</Year><Month>08</Month><Day>31</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-1293</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Aug</Month><Day>31</Day></PubDate></JournalIssue><Title>HIV medicine</Title><ISOAbbreviation>HIV Med.</ISOAbbreviation></Journal><ArticleTitle>The extent of B-cell activation and dysfunction preceding lymphoma development in HIV-positive people.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1111/hiv.12546</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">B-cell dysfunction and activation are thought to contribute to lymphoma development in HIV-positive people; however, the mechanisms are not well understood. We investigated levels of several markers of B-cell dysfunction [free light chain (FLC)-κ, FLC-λ, immunoglobulin G (IgG), IgA, IgM and IgD] prior to lymphoma diagnosis in HIV-positive people.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A nested matched case-control study was carried out within the EuroSIDA cohort, including 73 HIV-positive people with lymphoma and 143 HIV-positive lymphoma-free controls. Markers of B-cell dysfunction were measured in prospectively stored serial plasma samples collected before the diagnosis of lymphoma (or selection date in controls). Marker levels ≤ 2 and > 2 years prior to diagnosis were investigated.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Two-fold higher levels of FLC-κ [odds ratio (OR) 1.84; 95% confidence interval (CI) 1.19, 2.84], FLC-λ (OR 2.15; 95% CI 1.34, 3.46), IgG (OR 3.05; 95% CI 1.41, 6.59) and IgM (OR 1.46; 95% CI 1.01, 2.11) were associated with increased risk of lymphoma > 2 years prior to diagnosis, but not ≤ 2 years prior. Despite significant associations > 2 years prior to diagnosis, the predictive accuracy of each marker was poor, with FLC-λ emerging as the strongest candidate with a c-statistic of 0.67 (95% CI 0.58, 0.76).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">FLC-κ, FLC-λ and IgG levels were higher > 2 years before lymphoma diagnosis, suggesting that B-cell dysfunction occurs many years prior to lymphoma development. However, the predictive value of each marker was low and they are unlikely candidates for risk assessment for targeted intervention.</AbstractText><CopyrightInformation>© 2017 British HIV Association.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shepherd</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Research Department of Infection and Population Health, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borges</LastName><ForeName>Á H</ForeName><Initials>ÁH</Initials><AffiliationInfo><Affiliation>Centre of Excellence for Health, Immunity and Infections, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harvey</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Charing Cross Oncology Laboratory and Trophoblastic Disease Centre, Charing Cross Hospital Campus of Imperial College Healthcare National Health Service Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bower</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>National Centre for HIV Malignancy, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grulich</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Kirby Institute, The University of New South Wales, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silverberg</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Kaiser Permanente Northern California, Oakland, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weber</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ristola</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Viard</LastName><ForeName>J-P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>AP-HP, Diagnostic & Therapeutic Center, Hotel Dieu Hospital, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bogner</LastName><ForeName>J R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine IV, University of Munich, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gargalianos-Kakolyris</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>First Department of Internal Medicine and Infectious Diseases Unit, General Hospital of Athens "G. Gennimatas", Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mussini</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Clinic of Infectious and Tropical Diseases, University of Modena and Reggio Emilia, Azienda Policlinico, Modena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mansinho</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Hospital Egas Moniz-CHLO, E.P.E., Lisboa, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yust</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Ichilov Hospital, Tel Aviv, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paduta</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Gomel Regional Centre for Hygiene, Gomel, Belarus.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jilich</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University, Prague, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smiatacz</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Infectious Diseases Department, Medical University of Gdańsk, Gdańsk, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Radoi</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Clinical Hospital of Infectious and Tropical Diseases 'Dr. Victor Babeş', Bucharest, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tomazic</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Plomgaard</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frikke-Schmidt</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lundgren</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Centre of Excellence for Health, Immunity and Infections, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mocroft</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Research Department of Infection and Population Health, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>EuroSIDA in EuroCOORD</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>08</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>HIV Med</MedlineTA><NlmUniqueID>100897392</NlmUniqueID><ISSNLinking>1464-2662</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">HIV</Keyword><Keyword MajorTopicYN="N">B-cell dysfunction</Keyword><Keyword MajorTopicYN="N">biomarkers</Keyword><Keyword MajorTopicYN="N">free light chains</Keyword><Keyword MajorTopicYN="N">immunoglobulins</Keyword><Keyword MajorTopicYN="N">lymphoma</Keyword></KeywordList><InvestigatorList><Investigator ValidYN="Y"><LastName>Losso</LastName><ForeName>M</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kundro</LastName><ForeName>M</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Schmied</LastName><ForeName>B</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Karpov</LastName><ForeName>I</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vassilenko</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mitsura</LastName><ForeName>V M</ForeName><Initials>VM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Paduto</LastName><ForeName>D</ForeName><Initials>D</Initials></Investigator><Investigator 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