Voriconazole and squamous cell carcinoma after lung transplantation: A multicenter study.
Identifieur interne : 000497 ( PubMed/Curation ); précédent : 000496; suivant : 000498Voriconazole and squamous cell carcinoma after lung transplantation: A multicenter study.
Auteurs : B. Hamandi [Canada] ; C. Fegbeutel [Allemagne] ; F P Silveira [États-Unis] ; E A Verschuuren [Pays-Bas] ; M. Younus [États-Unis] ; J. Mo [États-Unis] ; J. Yan [États-Unis] ; P. Ussetti [Espagne] ; P V Chin-Hong [États-Unis] ; A. Solé [Espagne] ; C L Holmes-Liew [Australie] ; E M Billaud [France] ; P A Grossi [Italie] ; O. Manuel [Suisse] ; D J Levine [États-Unis] ; R G Barbers [États-Unis] ; D. Hadjiliadis [États-Unis] ; J. Aram [États-Unis] ; L G Singer [Canada] ; S. Husain [Canada]Source :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6143 ] ; 2017.
Abstract
This study evaluated the independent contribution of voriconazole to the development of squamous cell carcinoma (SCC) in lung transplant recipients, by attempting to account for important confounding factors, particularly immunosuppression. This international, multicenter, retrospective, cohort study included adult patients who underwent lung transplantation during 2005-2008. Cox regression analysis was used to assess the effects of voriconazole and other azoles, analyzed as time-dependent variables, on the risk of developing biopsy-confirmed SCC. Nine hundred lung transplant recipients were included. Median follow-up time from transplantation to end of follow-up was 3.51 years. In a Cox regression model, exposure to voriconazole alone (adjusted hazard ratio 2.39, 95% confidence interval 1.31-4.37) and exposure to voriconazole and other azole(s) (adjusted hazard ratio 3.45, 95% confidence interval 1.07-11.06) were associated with SCC compared with those unexposed after controlling for important confounders including immunosuppressants. Exposure to voriconazole was associated with increased risk of SCC of the skin in lung transplant recipients. Residual confounding could not be ruled out because of the use of proxy variables to control for some confounders. Benefits of voriconazole use when prescribed to lung transplant recipients should be carefully weighed versus the potential risk of SCC. EU PAS registration number: EUPAS5269.
DOI: 10.1111/ajt.14500
PubMed: 28898527
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<author><name sortKey="Holmes Liew, C L" sort="Holmes Liew, C L" uniqKey="Holmes Liew C" first="C L" last="Holmes-Liew">C L Holmes-Liew</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Voriconazole and squamous cell carcinoma after lung transplantation: A multicenter study.</title>
<author><name sortKey="Hamandi, B" sort="Hamandi, B" uniqKey="Hamandi B" first="B" last="Hamandi">B. Hamandi</name>
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<author><name sortKey="Yan, J" sort="Yan, J" uniqKey="Yan J" first="J" last="Yan">J. Yan</name>
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<author><name sortKey="Ussetti, P" sort="Ussetti, P" uniqKey="Ussetti P" first="P" last="Ussetti">P. Ussetti</name>
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<author><name sortKey="Chin Hong, P V" sort="Chin Hong, P V" uniqKey="Chin Hong P" first="P V" last="Chin-Hong">P V Chin-Hong</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Sole, A" sort="Sole, A" uniqKey="Sole A" first="A" last="Solé">A. Solé</name>
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<wicri:regionArea>Respiratory Department, University and Polytechnic Hospital La Fe, Universidad de Valencia, Valencia</wicri:regionArea>
</affiliation>
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<author><name sortKey="Holmes Liew, C L" sort="Holmes Liew, C L" uniqKey="Holmes Liew C" first="C L" last="Holmes-Liew">C L Holmes-Liew</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Lung Research, Hanson Institute, and Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide</wicri:regionArea>
</affiliation>
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<author><name sortKey="Billaud, E M" sort="Billaud, E M" uniqKey="Billaud E" first="E M" last="Billaud">E M Billaud</name>
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<author><name sortKey="Manuel, O" sort="Manuel, O" uniqKey="Manuel O" first="O" last="Manuel">O. Manuel</name>
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<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Infectious Diseases Service and Transplantation Center, University Hospital of Lausanne, Lausanne</wicri:regionArea>
</affiliation>
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<author><name sortKey="Levine, D J" sort="Levine, D J" uniqKey="Levine D" first="D J" last="Levine">D J Levine</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Pulmonary and Critical Care Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX</wicri:regionArea>
</affiliation>
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<author><name sortKey="Barbers, R G" sort="Barbers, R G" uniqKey="Barbers R" first="R G" last="Barbers">R G Barbers</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Hadjiliadis, D" sort="Hadjiliadis, D" uniqKey="Hadjiliadis D" first="D" last="Hadjiliadis">D. Hadjiliadis</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
</affiliation>
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<author><name sortKey="Aram, J" sort="Aram, J" uniqKey="Aram J" first="J" last="Aram">J. Aram</name>
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</affiliation>
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<author><name sortKey="Singer, L G" sort="Singer, L G" uniqKey="Singer L" first="L G" last="Singer">L G Singer</name>
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<country xml:lang="fr">Canada</country>
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<author><name sortKey="Husain, S" sort="Husain, S" uniqKey="Husain S" first="S" last="Husain">S. Husain</name>
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<country xml:lang="fr">Canada</country>
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<front><div type="abstract" xml:lang="en">This study evaluated the independent contribution of voriconazole to the development of squamous cell carcinoma (SCC) in lung transplant recipients, by attempting to account for important confounding factors, particularly immunosuppression. This international, multicenter, retrospective, cohort study included adult patients who underwent lung transplantation during 2005-2008. Cox regression analysis was used to assess the effects of voriconazole and other azoles, analyzed as time-dependent variables, on the risk of developing biopsy-confirmed SCC. Nine hundred lung transplant recipients were included. Median follow-up time from transplantation to end of follow-up was 3.51 years. In a Cox regression model, exposure to voriconazole alone (adjusted hazard ratio 2.39, 95% confidence interval 1.31-4.37) and exposure to voriconazole and other azole(s) (adjusted hazard ratio 3.45, 95% confidence interval 1.07-11.06) were associated with SCC compared with those unexposed after controlling for important confounders including immunosuppressants. Exposure to voriconazole was associated with increased risk of SCC of the skin in lung transplant recipients. Residual confounding could not be ruled out because of the use of proxy variables to control for some confounders. Benefits of voriconazole use when prescribed to lung transplant recipients should be carefully weighed versus the potential risk of SCC. EU PAS registration number: EUPAS5269.</div>
</front>
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<Title>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</Title>
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<ArticleTitle>Voriconazole and squamous cell carcinoma after lung transplantation: A multicenter study.</ArticleTitle>
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<Abstract><AbstractText>This study evaluated the independent contribution of voriconazole to the development of squamous cell carcinoma (SCC) in lung transplant recipients, by attempting to account for important confounding factors, particularly immunosuppression. This international, multicenter, retrospective, cohort study included adult patients who underwent lung transplantation during 2005-2008. Cox regression analysis was used to assess the effects of voriconazole and other azoles, analyzed as time-dependent variables, on the risk of developing biopsy-confirmed SCC. Nine hundred lung transplant recipients were included. Median follow-up time from transplantation to end of follow-up was 3.51 years. In a Cox regression model, exposure to voriconazole alone (adjusted hazard ratio 2.39, 95% confidence interval 1.31-4.37) and exposure to voriconazole and other azole(s) (adjusted hazard ratio 3.45, 95% confidence interval 1.07-11.06) were associated with SCC compared with those unexposed after controlling for important confounders including immunosuppressants. Exposure to voriconazole was associated with increased risk of SCC of the skin in lung transplant recipients. Residual confounding could not be ruled out because of the use of proxy variables to control for some confounders. Benefits of voriconazole use when prescribed to lung transplant recipients should be carefully weighed versus the potential risk of SCC. EU PAS registration number: EUPAS5269.</AbstractText>
<CopyrightInformation>© 2017 The American Society of Transplantation and the American Society of Transplant Surgeons.</CopyrightInformation>
</Abstract>
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<ForeName>B</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacy, University Health Network, Toronto, ON, Canada.</Affiliation>
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<ForeName>C</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany.</Affiliation>
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<ForeName>F P</ForeName>
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<AffiliationInfo><Affiliation>Pfizer Inc., New York, NY, USA.</Affiliation>
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<ForeName>P</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Respiratory Department, Hospital Puerta de Hierro, Madrid, Spain.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Chin-Hong</LastName>
<ForeName>P V</ForeName>
<Initials>PV</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Solé</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Respiratory Department, University and Polytechnic Hospital La Fe, Universidad de Valencia, Valencia, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Holmes-Liew</LastName>
<ForeName>C L</ForeName>
<Initials>CL</Initials>
<AffiliationInfo><Affiliation>Lung Research, Hanson Institute, and Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, Australia.</Affiliation>
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<Author ValidYN="Y"><LastName>Billaud</LastName>
<ForeName>E M</ForeName>
<Initials>EM</Initials>
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<Author ValidYN="Y"><LastName>Grossi</LastName>
<ForeName>P A</ForeName>
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<Author ValidYN="Y"><LastName>Manuel</LastName>
<ForeName>O</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Infectious Diseases Service and Transplantation Center, University Hospital of Lausanne, Lausanne, Switzerland.</Affiliation>
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<Author ValidYN="Y"><LastName>Levine</LastName>
<ForeName>D J</ForeName>
<Initials>DJ</Initials>
<AffiliationInfo><Affiliation>Division of Pulmonary and Critical Care Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.</Affiliation>
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<ForeName>R G</ForeName>
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<ForeName>D</ForeName>
<Initials>D</Initials>
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<ForeName>J</ForeName>
<Initials>J</Initials>
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<ForeName>L G</ForeName>
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<AffiliationInfo><Affiliation>Toronto Lung Transplant Program, University Health Network, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Husain</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
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</AffiliationInfo>
</Author>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>09</Month>
<Day>12</Day>
</ArticleDate>
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<MedlineTA>Am J Transplant</MedlineTA>
<NlmUniqueID>100968638</NlmUniqueID>
<ISSNLinking>1600-6135</ISSNLinking>
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<Keyword MajorTopicYN="N">clinical research/practice</Keyword>
<Keyword MajorTopicYN="N">complication: malignant</Keyword>
<Keyword MajorTopicYN="N">health services and outcomes research</Keyword>
<Keyword MajorTopicYN="N">infection and infectious agents - fungal</Keyword>
<Keyword MajorTopicYN="N">infectious disease</Keyword>
<Keyword MajorTopicYN="N">lung disease</Keyword>
<Keyword MajorTopicYN="N">lung transplantation/pulmonology</Keyword>
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<Month>06</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2017</Year>
<Month>08</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>08</Month>
<Day>30</Day>
</PubMedPubDate>
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<Month>9</Month>
<Day>13</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<Month>9</Month>
<Day>13</Day>
<Hour>6</Hour>
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<Day>13</Day>
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<PublicationStatus>aheadofprint</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28898527</ArticleId>
<ArticleId IdType="doi">10.1111/ajt.14500</ArticleId>
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