AustralieFrV1, PubMed, Curation, bibRecord, 000447

Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture.

Identifieur interne : 000447 ( PubMed/Curation ); précédent : 000446; suivant : 000448

Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture.

Auteurs : Fanny Grillet [France] ; Elsa Bayet [France] ; Olivia Villeronce [France] ; Luke Zappia [Australie] ; Ebba Louise Lagerqvist [France] ; Sebastian Lunke [Australie] ; Emmanuelle Charafe-Jauffret [France] ; Kym Pham [Australie] ; Christina Molck [Australie] ; Nathalie Rolland [France] ; Jean François Bourgaux [France] ; Michel Prudhomme [France] ; Claire Philippe [France] ; Sophie Bravo [France] ; Jean Christophe Boyer [France] ; Lucile Canterel-Thouennon [France] ; Graham Roy Taylor [Australie] ; Arthur Hsu [Australie] ; Jean Marc Pascussi [France] ; Frédéric Hollande [France] ; Julie Pannequin [France]

Source :

Gut [ 1468-3288 ] ; 2017.

RBID : pubmed:27456153

Descripteurs français

KwdFr :
- ARN tumoral (analyse), Aldehyde dehydrogenase (génétique), Aldehyde dehydrogenase (métabolisme), Analyse de séquence d'ARN, Animaux, Antigènes CD44 (génétique), Antigènes CD44 (métabolisme), Antinéoplasiques (métabolisme), Auto-renouvellement cellulaire, Cellules cancéreuses en culture, Cellules souches tumorales (enzymologie), Cellules souches tumorales (physiologie), Cellules tumorales circulantes (métabolisme), Culture primaire de cellules, Différenciation cellulaire, Dipeptidyl peptidase 4 (génétique), Dipeptidyl peptidase 4 (métabolisme), Humains, Inactivation métabolique (génétique), Phénotype, Régulation positive, Résistance aux médicaments antinéoplasiques (génétique), Souris, Transplantation tumorale, Tumeurs colorectales (anatomopathologie), Tumeurs colorectales (génétique), Tumeurs colorectales (sang), Tumeurs du foie (anatomopathologie), Tumeurs du foie (secondaire).
MESH :
- analyse : ARN tumoral.
- anatomopathologie : Tumeurs colorectales, Tumeurs du foie.
- enzymologie : Cellules souches tumorales.
- génétique : Aldehyde dehydrogenase, Antigènes CD44, Dipeptidyl peptidase 4, Inactivation métabolique, Résistance aux médicaments antinéoplasiques, Tumeurs colorectales.
- métabolisme : Aldehyde dehydrogenase, Antigènes CD44, Antinéoplasiques, Cellules tumorales circulantes, Dipeptidyl peptidase 4.
- physiologie : Cellules souches tumorales.
- sang : Tumeurs colorectales.
- secondaire : Tumeurs du foie.
- Analyse de séquence d'ARN, Animaux, Auto-renouvellement cellulaire, Cellules cancéreuses en culture, Culture primaire de cellules, Différenciation cellulaire, Humains, Phénotype, Régulation positive, Souris, Transplantation tumorale.

English descriptors

KwdEn :
- Aldehyde Dehydrogenase (genetics), Aldehyde Dehydrogenase (metabolism), Animals, Antigens, CD44 (genetics), Antigens, CD44 (metabolism), Antineoplastic Agents (metabolism), Cell Differentiation, Cell Self Renewal, Colorectal Neoplasms (blood), Colorectal Neoplasms (genetics), Colorectal Neoplasms (pathology), Dipeptidyl Peptidase 4 (genetics), Dipeptidyl Peptidase 4 (metabolism), Drug Resistance, Neoplasm (genetics), Humans, Inactivation, Metabolic (genetics), Liver Neoplasms (pathology), Liver Neoplasms (secondary), Mice, Neoplasm Transplantation, Neoplastic Cells, Circulating (metabolism), Neoplastic Stem Cells (enzymology), Neoplastic Stem Cells (physiology), Phenotype, Primary Cell Culture, RNA, Neoplasm (analysis), Sequence Analysis, RNA, Tumor Cells, Cultured, Up-Regulation.
MESH :
- chemical , analysis : RNA, Neoplasm.
- chemical , genetics : Aldehyde Dehydrogenase, Antigens, CD44, Dipeptidyl Peptidase 4.
- chemical , metabolism : Aldehyde Dehydrogenase, Antigens, CD44, Antineoplastic Agents, Dipeptidyl Peptidase 4.
- blood : Colorectal Neoplasms.
- enzymology : Neoplastic Stem Cells.
- genetics : Colorectal Neoplasms, Drug Resistance, Neoplasm, Inactivation, Metabolic.
- metabolism : Neoplastic Cells, Circulating.
- pathology : Colorectal Neoplasms, Liver Neoplasms.
- physiology : Neoplastic Stem Cells.
- secondary : Liver Neoplasms.
- Animals, Cell Differentiation, Cell Self Renewal, Humans, Mice, Neoplasm Transplantation, Phenotype, Primary Cell Culture, Sequence Analysis, RNA, Tumor Cells, Cultured, Up-Regulation.

Abstract

Although counting of circulating tumour cells (CTC) has attracted a broad interest as potential markers of tumour progression and treatment response, the lack of functional characterisation of these cells had become a bottleneck in taking these observations to the clinic. Our objective was to culture these cells in order to understand them and exploit their therapeutic potential to the full.

DOI: 10.1136/gutjnl-2016-311447
PubMed: 27456153

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Le document en format XML

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<author><name sortKey="Charafe Jauffret, Emmanuelle" sort="Charafe Jauffret, Emmanuelle" uniqKey="Charafe Jauffret E" first="Emmanuelle" last="Charafe-Jauffret">Emmanuelle Charafe-Jauffret</name>
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<author><name sortKey="Molck, Christina" sort="Molck, Christina" uniqKey="Molck C" first="Christina" last="Molck">Christina Molck</name>
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<author><name sortKey="Rolland, Nathalie" sort="Rolland, Nathalie" uniqKey="Rolland N" first="Nathalie" last="Rolland">Nathalie Rolland</name>
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<author><name sortKey="Bourgaux, Jean Francois" sort="Bourgaux, Jean Francois" uniqKey="Bourgaux J" first="Jean François" last="Bourgaux">Jean François Bourgaux</name>
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<author><name sortKey="Boyer, Jean Christophe" sort="Boyer, Jean Christophe" uniqKey="Boyer J" first="Jean Christophe" last="Boyer">Jean Christophe Boyer</name>
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<author><name sortKey="Canterel Thouennon, Lucile" sort="Canterel Thouennon, Lucile" uniqKey="Canterel Thouennon L" first="Lucile" last="Canterel-Thouennon">Lucile Canterel-Thouennon</name>
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<author><name sortKey="Taylor, Graham Roy" sort="Taylor, Graham Roy" uniqKey="Taylor G" first="Graham Roy" last="Taylor">Graham Roy Taylor</name>
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<author><name sortKey="Hsu, Arthur" sort="Hsu, Arthur" uniqKey="Hsu A" first="Arthur" last="Hsu">Arthur Hsu</name>
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<author><name sortKey="Pascussi, Jean Marc" sort="Pascussi, Jean Marc" uniqKey="Pascussi J" first="Jean Marc" last="Pascussi">Jean Marc Pascussi</name>
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<author><name sortKey="Hollande, Frederic" sort="Hollande, Frederic" uniqKey="Hollande F" first="Frédéric" last="Hollande">Frédéric Hollande</name>
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<author><name sortKey="Pannequin, Julie" sort="Pannequin, Julie" uniqKey="Pannequin J" first="Julie" last="Pannequin">Julie Pannequin</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture.</title>
<author><name sortKey="Grillet, Fanny" sort="Grillet, Fanny" uniqKey="Grillet F" first="Fanny" last="Grillet">Fanny Grillet</name>
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<author><name sortKey="Bayet, Elsa" sort="Bayet, Elsa" uniqKey="Bayet E" first="Elsa" last="Bayet">Elsa Bayet</name>
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<author><name sortKey="Villeronce, Olivia" sort="Villeronce, Olivia" uniqKey="Villeronce O" first="Olivia" last="Villeronce">Olivia Villeronce</name>
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<author><name sortKey="Zappia, Luke" sort="Zappia, Luke" uniqKey="Zappia L" first="Luke" last="Zappia">Luke Zappia</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Pathology, University of Melbourne, Parkville, Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lagerqvist, Ebba Louise" sort="Lagerqvist, Ebba Louise" uniqKey="Lagerqvist E" first="Ebba Louise" last="Lagerqvist">Ebba Louise Lagerqvist</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Lunke, Sebastian" sort="Lunke, Sebastian" uniqKey="Lunke S" first="Sebastian" last="Lunke">Sebastian Lunke</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Pathology, University of Melbourne, Parkville, Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Charafe Jauffret, Emmanuelle" sort="Charafe Jauffret, Emmanuelle" uniqKey="Charafe Jauffret E" first="Emmanuelle" last="Charafe-Jauffret">Emmanuelle Charafe-Jauffret</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Recherche en Cancérologie de Marseille, U1068 Inserm, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pham, Kym" sort="Pham, Kym" uniqKey="Pham K" first="Kym" last="Pham">Kym Pham</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Pathology, University of Melbourne, Parkville, Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Molck, Christina" sort="Molck, Christina" uniqKey="Molck C" first="Christina" last="Molck">Christina Molck</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Pathology, University of Melbourne, Parkville, Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rolland, Nathalie" sort="Rolland, Nathalie" uniqKey="Rolland N" first="Nathalie" last="Rolland">Nathalie Rolland</name>
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</affiliation>
</author>
<author><name sortKey="Bourgaux, Jean Francois" sort="Bourgaux, Jean Francois" uniqKey="Bourgaux J" first="Jean François" last="Bourgaux">Jean François Bourgaux</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Service d'Hépato-Gastroentérologie, CHU Carémeau, Nîmes</wicri:regionArea>
</affiliation>
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<author><name sortKey="Prudhomme, Michel" sort="Prudhomme, Michel" uniqKey="Prudhomme M" first="Michel" last="Prudhomme">Michel Prudhomme</name>
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</affiliation>
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<author><name sortKey="Philippe, Claire" sort="Philippe, Claire" uniqKey="Philippe C" first="Claire" last="Philippe">Claire Philippe</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Chirurgie Digestive, CHU Carémeau, Nîmes</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bravo, Sophie" sort="Bravo, Sophie" uniqKey="Bravo S" first="Sophie" last="Bravo">Sophie Bravo</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Biochimie, CHU Carémeau, Nîmes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Biochimie, CHU Carémeau, Nîmes</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Boyer, Jean Christophe" sort="Boyer, Jean Christophe" uniqKey="Boyer J" first="Jean Christophe" last="Boyer">Jean Christophe Boyer</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Biochimie, CHU Carémeau, Nîmes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Biochimie, CHU Carémeau, Nîmes</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Canterel Thouennon, Lucile" sort="Canterel Thouennon, Lucile" uniqKey="Canterel Thouennon L" first="Lucile" last="Canterel-Thouennon">Lucile Canterel-Thouennon</name>
<affiliation wicri:level="1"><nlm:affiliation>Plateforme MPCC-SIRIC Montpellier Cancer, IRCM, Montpellier, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Plateforme MPCC-SIRIC Montpellier Cancer, IRCM, Montpellier</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Taylor, Graham Roy" sort="Taylor, Graham Roy" uniqKey="Taylor G" first="Graham Roy" last="Taylor">Graham Roy Taylor</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Pathology, University of Melbourne, Parkville, Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hsu, Arthur" sort="Hsu, Arthur" uniqKey="Hsu A" first="Arthur" last="Hsu">Arthur Hsu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Pathology, University of Melbourne, Parkville, Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pascussi, Jean Marc" sort="Pascussi, Jean Marc" uniqKey="Pascussi J" first="Jean Marc" last="Pascussi">Jean Marc Pascussi</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hollande, Frederic" sort="Hollande, Frederic" uniqKey="Hollande F" first="Frédéric" last="Hollande">Frédéric Hollande</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pannequin, Julie" sort="Pannequin, Julie" uniqKey="Pannequin J" first="Julie" last="Pannequin">Julie Pannequin</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Gut</title>
<idno type="eISSN">1468-3288</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aldehyde Dehydrogenase (genetics)</term>
<term>Aldehyde Dehydrogenase (metabolism)</term>
<term>Animals</term>
<term>Antigens, CD44 (genetics)</term>
<term>Antigens, CD44 (metabolism)</term>
<term>Antineoplastic Agents (metabolism)</term>
<term>Cell Differentiation</term>
<term>Cell Self Renewal</term>
<term>Colorectal Neoplasms (blood)</term>
<term>Colorectal Neoplasms (genetics)</term>
<term>Colorectal Neoplasms (pathology)</term>
<term>Dipeptidyl Peptidase 4 (genetics)</term>
<term>Dipeptidyl Peptidase 4 (metabolism)</term>
<term>Drug Resistance, Neoplasm (genetics)</term>
<term>Humans</term>
<term>Inactivation, Metabolic (genetics)</term>
<term>Liver Neoplasms (pathology)</term>
<term>Liver Neoplasms (secondary)</term>
<term>Mice</term>
<term>Neoplasm Transplantation</term>
<term>Neoplastic Cells, Circulating (metabolism)</term>
<term>Neoplastic Stem Cells (enzymology)</term>
<term>Neoplastic Stem Cells (physiology)</term>
<term>Phenotype</term>
<term>Primary Cell Culture</term>
<term>RNA, Neoplasm (analysis)</term>
<term>Sequence Analysis, RNA</term>
<term>Tumor Cells, Cultured</term>
<term>Up-Regulation</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN tumoral (analyse)</term>
<term>Aldehyde dehydrogenase (génétique)</term>
<term>Aldehyde dehydrogenase (métabolisme)</term>
<term>Analyse de séquence d'ARN</term>
<term>Animaux</term>
<term>Antigènes CD44 (génétique)</term>
<term>Antigènes CD44 (métabolisme)</term>
<term>Antinéoplasiques (métabolisme)</term>
<term>Auto-renouvellement cellulaire</term>
<term>Cellules cancéreuses en culture</term>
<term>Cellules souches tumorales (enzymologie)</term>
<term>Cellules souches tumorales (physiologie)</term>
<term>Cellules tumorales circulantes (métabolisme)</term>
<term>Culture primaire de cellules</term>
<term>Différenciation cellulaire</term>
<term>Dipeptidyl peptidase 4 (génétique)</term>
<term>Dipeptidyl peptidase 4 (métabolisme)</term>
<term>Humains</term>
<term>Inactivation métabolique (génétique)</term>
<term>Phénotype</term>
<term>Régulation positive</term>
<term>Résistance aux médicaments antinéoplasiques (génétique)</term>
<term>Souris</term>
<term>Transplantation tumorale</term>
<term>Tumeurs colorectales (anatomopathologie)</term>
<term>Tumeurs colorectales (génétique)</term>
<term>Tumeurs colorectales (sang)</term>
<term>Tumeurs du foie (anatomopathologie)</term>
<term>Tumeurs du foie (secondaire)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Neoplasm</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Aldehyde Dehydrogenase</term>
<term>Antigens, CD44</term>
<term>Dipeptidyl Peptidase 4</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Aldehyde Dehydrogenase</term>
<term>Antigens, CD44</term>
<term>Antineoplastic Agents</term>
<term>Dipeptidyl Peptidase 4</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN tumoral</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs colorectales</term>
<term>Tumeurs du foie</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Colorectal Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Cellules souches tumorales</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Neoplastic Stem Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Colorectal Neoplasms</term>
<term>Drug Resistance, Neoplasm</term>
<term>Inactivation, Metabolic</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Aldehyde dehydrogenase</term>
<term>Antigènes CD44</term>
<term>Dipeptidyl peptidase 4</term>
<term>Inactivation métabolique</term>
<term>Résistance aux médicaments antinéoplasiques</term>
<term>Tumeurs colorectales</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neoplastic Cells, Circulating</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Aldehyde dehydrogenase</term>
<term>Antigènes CD44</term>
<term>Antinéoplasiques</term>
<term>Cellules tumorales circulantes</term>
<term>Dipeptidyl peptidase 4</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Colorectal Neoplasms</term>
<term>Liver Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cellules souches tumorales</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neoplastic Stem Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Tumeurs colorectales</term>
</keywords>
<keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Tumeurs du foie</term>
</keywords>
<keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Liver Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Differentiation</term>
<term>Cell Self Renewal</term>
<term>Humans</term>
<term>Mice</term>
<term>Neoplasm Transplantation</term>
<term>Phenotype</term>
<term>Primary Cell Culture</term>
<term>Sequence Analysis, RNA</term>
<term>Tumor Cells, Cultured</term>
<term>Up-Regulation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence d'ARN</term>
<term>Animaux</term>
<term>Auto-renouvellement cellulaire</term>
<term>Cellules cancéreuses en culture</term>
<term>Culture primaire de cellules</term>
<term>Différenciation cellulaire</term>
<term>Humains</term>
<term>Phénotype</term>
<term>Régulation positive</term>
<term>Souris</term>
<term>Transplantation tumorale</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Although counting of circulating tumour cells (CTC) has attracted a broad interest as potential markers of tumour progression and treatment response, the lack of functional characterisation of these cells had become a bottleneck in taking these observations to the clinic. Our objective was to culture these cells in order to understand them and exploit their therapeutic potential to the full.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27456153</PMID>
<DateCreated><Year>2016</Year>
<Month>07</Month>
<Day>26</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>09</Month>
<Day>25</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>11</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-3288</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>66</Volume>
<Issue>10</Issue>
<PubDate><Year>2017</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Gut</Title>
<ISOAbbreviation>Gut</ISOAbbreviation>
</Journal>
<ArticleTitle>Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture.</ArticleTitle>
<Pagination><MedlinePgn>1802-1810</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1136/gutjnl-2016-311447</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Although counting of circulating tumour cells (CTC) has attracted a broad interest as potential markers of tumour progression and treatment response, the lack of functional characterisation of these cells had become a bottleneck in taking these observations to the clinic. Our objective was to culture these cells in order to understand them and exploit their therapeutic potential to the full.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Here, hypothesising that some CTC potentially have cancer stem cell (CSC) phenotype, we generated several CTC lines from the blood of patients with advanced metastatic colorectal cancer (CRC) based on their self-renewal abilities. Multiple standard tests were then employed to characterise these cells.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Our CTC lines self-renew, express CSC markers and have multilineage differentiation ability, both in vitro and in vivo. Patient-derived CTC lines are tumorigenic in subcutaneous xenografts and are also able to colonise the liver after intrasplenic injection. RNA sequencing analyses strikingly demonstrate that drug metabolising pathways represent the most upregulated feature among CTC lines in comparison with primary CRC cells grown under similar conditions. This result is corroborated by the high resistance of the CTC lines to conventional cytotoxic compounds.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Taken together, our results directly demonstrate the existence of patient-derived colorectal CTCs that bear all the functional attributes of CSCs. The CTC culture model described here is simple and takes <1 month from blood collection to drug testing, therefore, routine clinical application could facilitate access to personalised medicine.</AbstractText>
<AbstractText Label="CLINICAL TRIAL REGISTRATION" NlmCategory="BACKGROUND">ClinicalTrial.gov NCT01577511.</AbstractText>
<CopyrightInformation>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Grillet</LastName>
<ForeName>Fanny</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Montpellier, UMR5203, Montpellier, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bayet</LastName>
<ForeName>Elsa</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Montpellier, UMR5203, Montpellier, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Villeronce</LastName>
<ForeName>Olivia</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Montpellier, UMR5203, Montpellier, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zappia</LastName>
<ForeName>Luke</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lagerqvist</LastName>
<ForeName>Ebba Louise</ForeName>
<Initials>EL</Initials>
<AffiliationInfo><Affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Montpellier, UMR5203, Montpellier, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lunke</LastName>
<ForeName>Sebastian</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Charafe-Jauffret</LastName>
<ForeName>Emmanuelle</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Centre de Recherche en Cancérologie de Marseille, U1068 Inserm, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pham</LastName>
<ForeName>Kym</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Translational Pathology, The University of Melbourne, Parkville, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Molck</LastName>
<ForeName>Christina</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rolland</LastName>
<ForeName>Nathalie</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Service d'anatomopathologie, CHU Carémeau, Nîmes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bourgaux</LastName>
<ForeName>Jean François</ForeName>
<Initials>JF</Initials>
<AffiliationInfo><Affiliation>Service d'Hépato-Gastroentérologie, CHU Carémeau, Nîmes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Prudhomme</LastName>
<ForeName>Michel</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Service de Chirurgie Digestive, CHU Carémeau, Nîmes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Philippe</LastName>
<ForeName>Claire</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Service de Chirurgie Digestive, CHU Carémeau, Nîmes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bravo</LastName>
<ForeName>Sophie</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Laboratoire de Biochimie, CHU Carémeau, Nîmes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Boyer</LastName>
<ForeName>Jean Christophe</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Laboratoire de Biochimie, CHU Carémeau, Nîmes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Canterel-Thouennon</LastName>
<ForeName>Lucile</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Plateforme MPCC-SIRIC Montpellier Cancer, IRCM, Montpellier, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Taylor</LastName>
<ForeName>Graham Roy</ForeName>
<Initials>GR</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hsu</LastName>
<ForeName>Arthur</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pascussi</LastName>
<ForeName>Jean Marc</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Montpellier, UMR5203, Montpellier, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hollande</LastName>
<ForeName>Frédéric</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Montpellier, UMR5203, Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pannequin</LastName>
<ForeName>Julie</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Montpellier, UMR5203, Montpellier, France.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>07</Month>
<Day>25</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Gut</MedlineTA>
<NlmUniqueID>2985108R</NlmUniqueID>
<ISSNLinking>0017-5749</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018960">Antigens, CD44</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C112697">CD44v6 antigen</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012334">RNA, Neoplasm</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.2.1.3</RegistryNumber>
<NameOfSubstance UI="C510223">ALDH1A1 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.2.1.3</RegistryNumber>
<NameOfSubstance UI="D000444">Aldehyde Dehydrogenase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.14.5</RegistryNumber>
<NameOfSubstance UI="D018819">Dipeptidyl Peptidase 4</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
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   |texte=   Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture.
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture.

Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture.

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