UVB represses melanocyte cell migration and acts through β-catenin.
Identifieur interne : 000443 ( PubMed/Curation ); précédent : 000442; suivant : 000444UVB represses melanocyte cell migration and acts through β-catenin.
Auteurs : Juliette U. Bertrand [France] ; Valérie Petit [France] ; Elke Hacker [Australie] ; Irina Berlin [France] ; Nicholas K. Hayward [Australie] ; Marie Pouteaux [France] ; Evelyne Sage [France] ; David C. Whiteman [Australie] ; Lionel Larue [France]Source :
- Experimental dermatology [ 1600-0625 ] ; 2017.
Abstract
The exposure of skin to ultraviolet (UV) radiation can have both beneficial and deleterious effects: it can lead, for instance, to increased pigmentation and vitamin D synthesis but also to inflammation and skin cancer. UVB may induce genetic and epigenetic alterations and have reversible effects associated with post-translational and gene regulation modifications. β-catenin is a main driver in melanocyte development; although infrequently mutated in melanoma, its cellular localization and activity are frequently altered. Here, we evaluate the consequence of UVB on β-catenin in the melanocyte lineage. We report that in vivo, UVB induces cytoplasmic/nuclear relocalization of β-catenin in melanocytes of newborn mice and adult human skin. In mouse melanocyte and human melanoma cell lines in vitro, UVB increases β-catenin stability, accumulation in the nucleus and cotranscriptional activity, leading to the repression of cell motility and velocity. The activation of the β-catenin signalling pathway and its effect on migration by UVB are increased by an inhibitor of GSK3β, and decreased by an inhibitor of β-catenin. In conclusion, UVB represses melanocyte migration and does so by acting through the GSK3-β-catenin axis.
DOI: 10.1111/exd.13318
PubMed: 28191677
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Bertrand</name><affiliation wicri:level="1"><nlm:affiliation>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay</wicri:regionArea></affiliation></author><author><name sortKey="Petit, Valerie" sort="Petit, Valerie" uniqKey="Petit V" first="Valérie" last="Petit">Valérie Petit</name><affiliation wicri:level="1"><nlm:affiliation>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay</wicri:regionArea></affiliation></author><author><name sortKey="Hacker, Elke" sort="Hacker, Elke" uniqKey="Hacker E" first="Elke" last="Hacker">Elke Hacker</name><affiliation wicri:level="1"><nlm:affiliation>Queensland Institute of Medical Research, Brisbane, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea></affiliation></author><author><name sortKey="Berlin, Irina" sort="Berlin, Irina" uniqKey="Berlin I" first="Irina" last="Berlin">Irina Berlin</name><affiliation wicri:level="1"><nlm:affiliation>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay</wicri:regionArea></affiliation></author><author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K" last="Hayward">Nicholas K. Hayward</name><affiliation wicri:level="1"><nlm:affiliation>Queensland Institute of Medical Research, Brisbane, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea></affiliation></author><author><name sortKey="Pouteaux, Marie" sort="Pouteaux, Marie" uniqKey="Pouteaux M" first="Marie" last="Pouteaux">Marie Pouteaux</name><affiliation wicri:level="1"><nlm:affiliation>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay</wicri:regionArea></affiliation></author><author><name sortKey="Sage, Evelyne" sort="Sage, Evelyne" uniqKey="Sage E" first="Evelyne" last="Sage">Evelyne Sage</name><affiliation wicri:level="1"><nlm:affiliation>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay</wicri:regionArea></affiliation></author><author><name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C" last="Whiteman">David C. Whiteman</name><affiliation wicri:level="1"><nlm:affiliation>Queensland Institute of Medical Research, Brisbane, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea></affiliation></author><author><name sortKey="Larue, Lionel" sort="Larue, Lionel" uniqKey="Larue L" first="Lionel" last="Larue">Lionel Larue</name><affiliation wicri:level="1"><nlm:affiliation>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay</wicri:regionArea></affiliation></author></analytic><series><title level="j">Experimental dermatology</title><idno type="eISSN">1600-0625</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The exposure of skin to ultraviolet (UV) radiation can have both beneficial and deleterious effects: it can lead, for instance, to increased pigmentation and vitamin D synthesis but also to inflammation and skin cancer. UVB may induce genetic and epigenetic alterations and have reversible effects associated with post-translational and gene regulation modifications. β-catenin is a main driver in melanocyte development; although infrequently mutated in melanoma, its cellular localization and activity are frequently altered. Here, we evaluate the consequence of UVB on β-catenin in the melanocyte lineage. We report that in vivo, UVB induces cytoplasmic/nuclear relocalization of β-catenin in melanocytes of newborn mice and adult human skin. In mouse melanocyte and human melanoma cell lines in vitro, UVB increases β-catenin stability, accumulation in the nucleus and cotranscriptional activity, leading to the repression of cell motility and velocity. The activation of the β-catenin signalling pathway and its effect on migration by UVB are increased by an inhibitor of GSK3β, and decreased by an inhibitor of β-catenin. In conclusion, UVB represses melanocyte migration and does so by acting through the GSK3-β-catenin axis.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28191677</PMID><DateCreated><Year>2017</Year><Month>02</Month><Day>13</Day></DateCreated><DateRevised><Year>2017</Year><Month>09</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-0625</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>10</Issue><PubDate><Year>2017</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Experimental dermatology</Title><ISOAbbreviation>Exp. Dermatol.</ISOAbbreviation></Journal><ArticleTitle>UVB represses melanocyte cell migration and acts through β-catenin.</ArticleTitle><Pagination><MedlinePgn>875-882</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/exd.13318</ELocationID><Abstract><AbstractText>The exposure of skin to ultraviolet (UV) radiation can have both beneficial and deleterious effects: it can lead, for instance, to increased pigmentation and vitamin D synthesis but also to inflammation and skin cancer. UVB may induce genetic and epigenetic alterations and have reversible effects associated with post-translational and gene regulation modifications. β-catenin is a main driver in melanocyte development; although infrequently mutated in melanoma, its cellular localization and activity are frequently altered. Here, we evaluate the consequence of UVB on β-catenin in the melanocyte lineage. We report that in vivo, UVB induces cytoplasmic/nuclear relocalization of β-catenin in melanocytes of newborn mice and adult human skin. In mouse melanocyte and human melanoma cell lines in vitro, UVB increases β-catenin stability, accumulation in the nucleus and cotranscriptional activity, leading to the repression of cell motility and velocity. The activation of the β-catenin signalling pathway and its effect on migration by UVB are increased by an inhibitor of GSK3β, and decreased by an inhibitor of β-catenin. In conclusion, UVB represses melanocyte migration and does so by acting through the GSK3-β-catenin axis.</AbstractText><CopyrightInformation>© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bertrand</LastName><ForeName>Juliette U</ForeName><Initials>JU</Initials><AffiliationInfo><Affiliation>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ Paris-Sud, Univ Paris-Saclay, CNRS UMR 3347, Orsay, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Equipe Labellisée Ligue Contre le Cancer, Orsay, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petit</LastName><ForeName>Valérie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ Paris-Sud, Univ Paris-Saclay, CNRS UMR 3347, Orsay, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Equipe Labellisée Ligue Contre le Cancer, Orsay, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hacker</LastName><ForeName>Elke</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Queensland Institute of Medical Research, Brisbane, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berlin</LastName><ForeName>Irina</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ Paris-Sud, Univ Paris-Saclay, CNRS UMR 3347, Orsay, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Equipe Labellisée Ligue Contre le Cancer, Orsay, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hayward</LastName><ForeName>Nicholas K</ForeName><Initials>NK</Initials><AffiliationInfo><Affiliation>Queensland Institute of Medical Research, Brisbane, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pouteaux</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ Paris-Sud, Univ Paris-Saclay, CNRS UMR 3347, Orsay, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Equipe Labellisée Ligue Contre le Cancer, Orsay, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sage</LastName><ForeName>Evelyne</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ Paris-Sud, Univ Paris-Saclay, CNRS UMR 3347, Orsay, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Equipe Labellisée Ligue Contre le Cancer, Orsay, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Whiteman</LastName><ForeName>David C</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>Queensland Institute of Medical Research, Brisbane, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Larue</LastName><ForeName>Lionel</ForeName><Initials>L</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-2010-6107</Identifier><AffiliationInfo><Affiliation>Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ Paris-Sud, Univ Paris-Saclay, CNRS UMR 3347, Orsay, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Equipe Labellisée Ligue Contre le Cancer, Orsay, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>05</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>Denmark</Country><MedlineTA>Exp Dermatol</MedlineTA><NlmUniqueID>9301549</NlmUniqueID><ISSNLinking>0906-6705</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">BIO inhibitor</Keyword><Keyword MajorTopicYN="N">CHIR99021 inhibitor</Keyword><Keyword MajorTopicYN="N">human skin</Keyword><Keyword MajorTopicYN="N">iCRT3 inhibitor</Keyword><Keyword MajorTopicYN="N">mouse skin</Keyword><Keyword MajorTopicYN="N">p38</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate 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