Vancomycin-intermediate Staphylococcus aureus isolates are attenuated for virulence when compared with susceptible progenitors.
Identifieur interne : 000437 ( PubMed/Curation ); précédent : 000436; suivant : 000438Vancomycin-intermediate Staphylococcus aureus isolates are attenuated for virulence when compared with susceptible progenitors.
Auteurs : D R Cameron [Australie] ; Y-H Lin [Australie] ; S. Trouillet-Assant [France] ; V. Tafani [France] ; X. Kostoulias [Australie] ; E. Mouhtouris [Australie] ; N. Skinner [Australie] ; K. Visvanathan [Australie] ; S L Baines [Australie] ; B. Howden [Australie] ; I R Monk [Australie] ; F. Laurent [France] ; T P Stinear [Australie] ; B P Howden [Australie] ; A Y Peleg [Australie]Source :
- Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [ 1469-0691 ] ; 2017.
Abstract
Vancomycin-intermediate Staphylococcus aureus (VISA) is associated with genetic changes that may also impact upon pathogenicity. In the current study, we compared the virulence of clinical VISA strains with their isogenic vancomycin-susceptible progenitors (VSSA).
DOI: 10.1016/j.cmi.2017.03.027
PubMed: 28396035
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Electronic address: bhowden@unimelb.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity, Australia; Infectious Diseases and Microbiology Departments, Austin Health</wicri:regionArea></affiliation></author><author><name sortKey="Peleg, A Y" sort="Peleg, A Y" uniqKey="Peleg A" first="A Y" last="Peleg">A Y Peleg</name><affiliation wicri:level="1"><nlm:affiliation>Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Australia; Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Australia. Electronic address: anton.peleg@monash.edu.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Australia; Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28396035</idno><idno type="pmid">28396035</idno><idno type="doi">10.1016/j.cmi.2017.03.027</idno><idno type="wicri:Area/PubMed/Corpus">000439</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000439</idno><idno type="wicri:Area/PubMed/Curation">000437</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000437</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Vancomycin-intermediate Staphylococcus aureus isolates are attenuated for virulence when compared with susceptible progenitors.</title><author><name sortKey="Cameron, D R" sort="Cameron, D R" uniqKey="Cameron D" first="D R" last="Cameron">D R Cameron</name><affiliation wicri:level="1"><nlm:affiliation>Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Y H" sort="Lin, Y H" uniqKey="Lin Y" first="Y-H" last="Lin">Y-H Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity</wicri:regionArea></affiliation></author><author><name sortKey="Trouillet Assant, S" sort="Trouillet Assant, S" uniqKey="Trouillet Assant S" first="S" last="Trouillet-Assant">S. Trouillet-Assant</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, French National Reference Centre for Staphylococci, Hospices Civils de Lyon, International Centre of Infectiology Research, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Microbiology, French National Reference Centre for Staphylococci, Hospices Civils de Lyon, International Centre of Infectiology Research</wicri:regionArea></affiliation></author><author><name sortKey="Tafani, V" sort="Tafani, V" uniqKey="Tafani V" first="V" last="Tafani">V. Tafani</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, French National Reference Centre for Staphylococci, Hospices Civils de Lyon, International Centre of Infectiology Research, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Microbiology, French National Reference Centre for Staphylococci, Hospices Civils de Lyon, International Centre of Infectiology Research</wicri:regionArea></affiliation></author><author><name sortKey="Kostoulias, X" sort="Kostoulias, X" uniqKey="Kostoulias X" first="X" last="Kostoulias">X. Kostoulias</name><affiliation wicri:level="1"><nlm:affiliation>Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University</wicri:regionArea></affiliation></author><author><name sortKey="Mouhtouris, E" sort="Mouhtouris, E" uniqKey="Mouhtouris E" first="E" last="Mouhtouris">E. Mouhtouris</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, The University of Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Surgery, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Skinner, N" sort="Skinner, N" uniqKey="Skinner N" first="N" last="Skinner">N. Skinner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, The University of Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Visvanathan, K" sort="Visvanathan, K" uniqKey="Visvanathan K" first="K" last="Visvanathan">K. Visvanathan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, The University of Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, The University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Baines, S L" sort="Baines, S L" uniqKey="Baines S" first="S L" last="Baines">S L Baines</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity</wicri:regionArea></affiliation></author><author><name sortKey="Howden, B" sort="Howden, B" uniqKey="Howden B" first="B" last="Howden">B. Howden</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity</wicri:regionArea></affiliation></author><author><name sortKey="Monk, I R" sort="Monk, I R" uniqKey="Monk I" first="I R" last="Monk">I R Monk</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity</wicri:regionArea></affiliation></author><author><name sortKey="Laurent, F" sort="Laurent, F" uniqKey="Laurent F" first="F" last="Laurent">F. Laurent</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, French National Reference Centre for Staphylococci, Hospices Civils de Lyon, International Centre of Infectiology Research, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Microbiology, French National Reference Centre for Staphylococci, Hospices Civils de Lyon, International Centre of Infectiology Research</wicri:regionArea></affiliation></author><author><name sortKey="Stinear, T P" sort="Stinear, T P" uniqKey="Stinear T" first="T P" last="Stinear">T P Stinear</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity</wicri:regionArea></affiliation></author><author><name sortKey="Howden, B P" sort="Howden, B P" uniqKey="Howden B" first="B P" last="Howden">B P Howden</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity, Australia; Infectious Diseases and Microbiology Departments, Austin Health, Australia. Electronic address: bhowden@unimelb.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity, Australia; Infectious Diseases and Microbiology Departments, Austin Health</wicri:regionArea></affiliation></author><author><name sortKey="Peleg, A Y" sort="Peleg, A Y" uniqKey="Peleg A" first="A Y" last="Peleg">A Y Peleg</name><affiliation wicri:level="1"><nlm:affiliation>Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Australia; Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Australia. Electronic address: anton.peleg@monash.edu.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Australia; Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University</wicri:regionArea></affiliation></author></analytic><series><title level="j">Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases</title><idno type="eISSN">1469-0691</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Vancomycin-intermediate Staphylococcus aureus (VISA) is associated with genetic changes that may also impact upon pathogenicity. In the current study, we compared the virulence of clinical VISA strains with their isogenic vancomycin-susceptible progenitors (VSSA).</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28396035</PMID><DateCreated><Year>2017</Year><Month>04</Month><Day>11</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1469-0691</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>10</Issue><PubDate><Year>2017</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases</Title><ISOAbbreviation>Clin. Microbiol. Infect.</ISOAbbreviation></Journal><ArticleTitle>Vancomycin-intermediate Staphylococcus aureus isolates are attenuated for virulence when compared with susceptible progenitors.</ArticleTitle><Pagination><MedlinePgn>767-773</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1198-743X(17)30199-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cmi.2017.03.027</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Vancomycin-intermediate Staphylococcus aureus (VISA) is associated with genetic changes that may also impact upon pathogenicity. In the current study, we compared the virulence of clinical VISA strains with their isogenic vancomycin-susceptible progenitors (VSSA).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Production of the critical virulence protein, α toxin, was assessed using Western blot analysis and was correlated to agr activity using a bioluminescent agr-reporter. Cytotoxicity and intracellular persistence were compared ex vivo for VSSA and VISA within non-professional phagocytes (NPP). Virulence and host immune responses were further explored in vivo using a murine model of bacteraemia.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">VISA isolates produced up to 20-fold less α toxin compared with VSSA, and this was corroborated by either loss of agr activity due to agr mutation, or altered agr activity in the absence of mutation. VISA were less cytotoxic towards NPP and were associated with enhanced intracellular persistence, suggesting that NPP may act as a reservoir for VISA. Infection with VSSA strains produced higher mortality in a murine bacteraemia model (≥90% 7-day mortality) compared with infection with VISA isolates (20% to 50%, p <0.001). Mice infected with VISA produced a dampened immune response (4.6-fold reduction in interleukin-6, p <0.001) and persistent organ bacterial growth was observed for VISA strains out to 7 days.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These findings highlight the remarkable adaptability of S. aureus, whereby, in addition to having reduced antibiotic susceptibility, VISA alter the expression of pathogenic factors to circumvent the host immune response to favour persistent infection over acute virulence.</AbstractText><CopyrightInformation>Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cameron</LastName><ForeName>D R</ForeName><Initials>DR</Initials><AffiliationInfo><Affiliation>Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Y-H</ForeName><Initials>YH</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trouillet-Assant</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Microbiology, French National Reference Centre for Staphylococci, Hospices Civils de Lyon, International Centre of Infectiology Research, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tafani</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Microbiology, French National Reference Centre for Staphylococci, Hospices Civils de Lyon, International Centre of Infectiology Research, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kostoulias</LastName><ForeName>X</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mouhtouris</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Surgery, The University of Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Skinner</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Medicine, The University of Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Visvanathan</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Medicine, The University of Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baines</LastName><ForeName>S L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Howden</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monk</LastName><ForeName>I R</ForeName><Initials>IR</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laurent</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Microbiology, French National Reference Centre for Staphylococci, Hospices Civils de Lyon, International Centre of Infectiology Research, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stinear</LastName><ForeName>T P</ForeName><Initials>TP</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Howden</LastName><ForeName>B P</ForeName><Initials>BP</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection & Immunity, Australia; Infectious Diseases and Microbiology Departments, Austin Health, Australia. Electronic address: bhowden@unimelb.edu.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peleg</LastName><ForeName>A Y</ForeName><Initials>AY</Initials><AffiliationInfo><Affiliation>Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Australia; Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Australia. Electronic address: anton.peleg@monash.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>04</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Clin Microbiol Infect</MedlineTA><NlmUniqueID>9516420</NlmUniqueID><ISSNLinking>1198-743X</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Accessory gene regulator</Keyword><Keyword MajorTopicYN="N">Persistence</Keyword><Keyword MajorTopicYN="N">Staphylococcus aureus</Keyword><Keyword MajorTopicYN="N">Vancomycin-intermediate Staphylococcus aureus</Keyword><Keyword MajorTopicYN="N">Virulence</Keyword><Keyword MajorTopicYN="N">agr</Keyword><Keyword MajorTopicYN="N">α toxin</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>10</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>03</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>03</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>4</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>4</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>4</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28396035</ArticleId><ArticleId IdType="pii">S1198-743X(17)30199-4</ArticleId><ArticleId IdType="doi">10.1016/j.cmi.2017.03.027</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |