Epidemiology and treatment of pulmonary arterial hypertension.
Identifieur interne : 000432 ( PubMed/Curation ); précédent : 000431; suivant : 000433Epidemiology and treatment of pulmonary arterial hypertension.
Auteurs : Edmund M T. Lau [Australie] ; Eleni Giannoulatou [Australie] ; David S. Celermajer [Australie] ; Marc Humbert [France]Source :
- Nature reviews. Cardiology [ 1759-5010 ] ; 2017.
Abstract
In the past 2 decades, major changes have occurred in the epidemiological and treatment landscape of pulmonary arterial hypertension (PAH). Previously regarded as a disease of the young and middle-aged, contemporary registries from the Western world have demonstrated an increase in the age of patients with PAH, many of whom are elderly with multiple comorbidities. Another important observation is the improvement in survival of patients with PAH in the modern treatment era compared with historical cohorts, before the availability of advanced therapy. The management of PAH has also become more complex, and numerous drugs are now approved that target the endothelin 1, nitric oxide, and prostacyclin pathways. Combining drugs from different classes is now considered the standard of care and has been demonstrated to improve outcomes. Furthermore, the current treatment paradigm is the early use of combination therapy, often at the time of diagnosis, particularly in patients with severe disease. This Review provides a comprehensive update on the epidemiology and pharmacotherapy of PAH.
DOI: 10.1038/nrcardio.2017.84
PubMed: 28593996
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Lau</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Respiratory Medicine, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050</wicri:regionArea></affiliation></author><author><name sortKey="Giannoulatou, Eleni" sort="Giannoulatou, Eleni" uniqKey="Giannoulatou E" first="Eleni" last="Giannoulatou">Eleni Giannoulatou</name><affiliation wicri:level="1"><nlm:affiliation>Computational Genomics Laboratory, Victor Chang Cardiac Research Institute, Liverpool Street, Darlinghurst, NSW 2010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Computational Genomics Laboratory, Victor Chang Cardiac Research Institute, Liverpool Street, Darlinghurst, NSW 2010</wicri:regionArea></affiliation></author><author><name sortKey="Celermajer, David S" sort="Celermajer, David S" uniqKey="Celermajer D" first="David S" last="Celermajer">David S. Celermajer</name><affiliation wicri:level="1"><nlm:affiliation>Sydney Medical School, University of Sydney, Missenden Road, Camperdown, NSW 2050, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, Missenden Road, Camperdown, NSW 2050</wicri:regionArea></affiliation></author><author><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Rue du Général Leclerc, 94270 Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Rue du Général Leclerc, 94270 Le Kremlin-Bicêtre</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature reviews. Cardiology</title><idno type="eISSN">1759-5010</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the past 2 decades, major changes have occurred in the epidemiological and treatment landscape of pulmonary arterial hypertension (PAH). Previously regarded as a disease of the young and middle-aged, contemporary registries from the Western world have demonstrated an increase in the age of patients with PAH, many of whom are elderly with multiple comorbidities. Another important observation is the improvement in survival of patients with PAH in the modern treatment era compared with historical cohorts, before the availability of advanced therapy. The management of PAH has also become more complex, and numerous drugs are now approved that target the endothelin 1, nitric oxide, and prostacyclin pathways. Combining drugs from different classes is now considered the standard of care and has been demonstrated to improve outcomes. Furthermore, the current treatment paradigm is the early use of combination therapy, often at the time of diagnosis, particularly in patients with severe disease. This Review provides a comprehensive update on the epidemiology and pharmacotherapy of PAH.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">28593996</PMID><DateCreated><Year>2017</Year><Month>06</Month><Day>08</Day></DateCreated><DateRevised><Year>2017</Year><Month>09</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1759-5010</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><Issue>10</Issue><PubDate><Year>2017</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Nature reviews. Cardiology</Title><ISOAbbreviation>Nat Rev Cardiol</ISOAbbreviation></Journal><ArticleTitle>Epidemiology and treatment of pulmonary arterial hypertension.</ArticleTitle><Pagination><MedlinePgn>603-614</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/nrcardio.2017.84</ELocationID><Abstract><AbstractText>In the past 2 decades, major changes have occurred in the epidemiological and treatment landscape of pulmonary arterial hypertension (PAH). Previously regarded as a disease of the young and middle-aged, contemporary registries from the Western world have demonstrated an increase in the age of patients with PAH, many of whom are elderly with multiple comorbidities. Another important observation is the improvement in survival of patients with PAH in the modern treatment era compared with historical cohorts, before the availability of advanced therapy. The management of PAH has also become more complex, and numerous drugs are now approved that target the endothelin 1, nitric oxide, and prostacyclin pathways. Combining drugs from different classes is now considered the standard of care and has been demonstrated to improve outcomes. Furthermore, the current treatment paradigm is the early use of combination therapy, often at the time of diagnosis, particularly in patients with severe disease. This Review provides a comprehensive update on the epidemiology and pharmacotherapy of PAH.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lau</LastName><ForeName>Edmund M T</ForeName><Initials>EMT</Initials><AffiliationInfo><Affiliation>Department of Respiratory Medicine, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giannoulatou</LastName><ForeName>Eleni</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Computational Genomics Laboratory, Victor Chang Cardiac Research Institute, Liverpool Street, Darlinghurst, NSW 2010, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>St Vincent's Clinical School, University of New South Wales, Victoria Street, Darlinghurst, NSW 2010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Celermajer</LastName><ForeName>David S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Sydney Medical School, University of Sydney, Missenden Road, Camperdown, NSW 2050, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Cardiology, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Humbert</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Rue du Général Leclerc, 94270 Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR_S 999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Univ. Paris-Sud, Université Paris-Saclay, Avenue de la Résistance, 92350 Le Plessis-Robinson, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculté de Médecine, Univ. Paris-Sud, Université Paris-Saclay, Rue Gabriel Peri, 94270 Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>06</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat Rev Cardiol</MedlineTA><NlmUniqueID>101500075</NlmUniqueID><ISSNLinking>1759-5002</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Am J Respir Crit Care Med. 2006 Nov 1;174(9):1034-41</RefSource><PMID Version="1">16888289</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Am Coll Cardiol. 2010 May 4;55(18):1915-22</RefSource><PMID Version="1">20430262</PMID></CommentsCorrections><CommentsCorrections 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Version="1">15194174</PMID></CommentsCorrections></CommentsCorrectionsList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>6</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>6</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28593996</ArticleId><ArticleId IdType="pii">nrcardio.2017.84</ArticleId><ArticleId IdType="doi">10.1038/nrcardio.2017.84</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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