Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study.
Identifieur interne : 000415 ( PubMed/Curation ); précédent : 000414; suivant : 000416Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study.
Auteurs : Martin J. Van Den Bent [Pays-Bas] ; Brigitta Baumert [Allemagne] ; Sara C. Erridge [Royaume-Uni] ; Michael A. Vogelbaum [États-Unis] ; Anna K. Nowak [Australie] ; Marc Sanson [France] ; Alba Ariela Brandes [Italie] ; Paul M. Clement [Belgique] ; Jean Francais Baurain [Belgique] ; Warren P. Mason [Canada] ; Helen Wheeler [Australie] ; Olivier L. Chinot [France] ; Sanjeev Gill [Australie] ; Matthew Griffin [Royaume-Uni] ; David G. Brachman [États-Unis] ; Walter Taal [Pays-Bas] ; Roberta Rudà [Italie] ; Michael Weller [Suisse] ; Catherine Mcbain [Royaume-Uni] ; Jaap Reijneveld [Pays-Bas] ; Roelien H. Enting [Pays-Bas] ; Damien C. Weber [Suisse] ; Thierry Lesimple [France] ; Susan Clenton [Royaume-Uni] ; Anja Gijtenbeek [Pays-Bas] ; Sarah Pascoe [Royaume-Uni] ; Ulrich Herrlinger [Allemagne] ; Peter Hau [Allemagne] ; Frederic Dhermain [France] ; Irene Van Heuvel [Pays-Bas] ; Roger Stupp [Suisse] ; Ken Aldape [Canada] ; Robert B. Jenkins [États-Unis] ; Hendrikus Jan Dubbink [Pays-Bas] ; Winand N M. Dinjens [Pays-Bas] ; Pieter Wesseling [Pays-Bas] ; Sarah Nuyens [Belgique] ; Vassilis Golfinopoulos [Belgique] ; Thierry Gorlia [Belgique] ; Wolfgang Wick [Allemagne] ; Johan M. Kros [Pays-Bas]Source :
- Lancet (London, England) [ 1474-547X ] ; 2017.
Abstract
The role of temozolomide chemotherapy in newly diagnosed 1p/19q non-co-deleted anaplastic gliomas, which are associated with lower sensitivity to chemotherapy and worse prognosis than 1p/19q co-deleted tumours, is unclear. We assessed the use of radiotherapy with concurrent and adjuvant temozolomide in adults with non-co-deleted anaplastic gliomas.
DOI: 10.1016/S0140-6736(17)31442-3
PubMed: 28801186
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study.</title><author><name sortKey="Van Den Bent, Martin J" sort="Van Den Bent, Martin J" uniqKey="Van Den Bent M" first="Martin J" last="Van Den Bent">Martin J. Van Den Bent</name><affiliation wicri:level="1"><nlm:affiliation>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands. Electronic address: m.vandenbent@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Baumert, Brigitta" sort="Baumert, Brigitta" uniqKey="Baumert B" first="Brigitta" last="Baumert">Brigitta Baumert</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation-Oncology (MAASTRO), Maastricht University Medical Centre (MUMC), Maastricht, Netherlands; GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre (MUMC), Maastricht, Netherlands; Department of Radiation-Oncology, University of Münster, Münster, Germany; Paracelsus Clinic, Osnabrück, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiation-Oncology (MAASTRO), Maastricht University Medical Centre (MUMC), Maastricht, Netherlands; GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre (MUMC), Maastricht, Netherlands; Department of Radiation-Oncology, University of Münster, Münster, Germany; Paracelsus Clinic, Osnabrück</wicri:regionArea></affiliation></author><author><name sortKey="Erridge, Sara C" sort="Erridge, Sara C" uniqKey="Erridge S" first="Sara C" last="Erridge">Sara C. Erridge</name><affiliation wicri:level="1"><nlm:affiliation>Edinburgh Centre for Neuro-Oncology, Western General Hospital, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Edinburgh Centre for Neuro-Oncology, Western General Hospital, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Vogelbaum, Michael A" sort="Vogelbaum, Michael A" uniqKey="Vogelbaum M" first="Michael A" last="Vogelbaum">Michael A. Vogelbaum</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA; Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA; Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH</wicri:regionArea></affiliation></author><author><name sortKey="Nowak, Anna K" sort="Nowak, Anna K" uniqKey="Nowak A" first="Anna K" last="Nowak">Anna K. Nowak</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia; Co-Operative Group for Neuro-Oncology, University of Sydney, Camperdown, NSW, Australia; Department of Medical Oncology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia; Co-Operative Group for Neuro-Oncology, University of Sydney, Camperdown, NSW, Australia; Department of Medical Oncology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA</wicri:regionArea></affiliation></author><author><name sortKey="Sanson, Marc" sort="Sanson, Marc" uniqKey="Sanson M" first="Marc" last="Sanson">Marc Sanson</name><affiliation wicri:level="1"><nlm:affiliation>Sorbonne Universités UPMC, University Paris VI, INSERM, CNRS, APHP, Institut du Cerveau et de la Moelle (ICM), Hôpital Pitié-Salpêtrière, F-75013, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Sorbonne Universités UPMC, University Paris VI, INSERM, CNRS, APHP, Institut du Cerveau et de la Moelle (ICM), Hôpital Pitié-Salpêtrière, F-75013, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Brandes, Alba Ariela" sort="Brandes, Alba Ariela" uniqKey="Brandes A" first="Alba Ariela" last="Brandes">Alba Ariela Brandes</name><affiliation wicri:level="1"><nlm:affiliation>Medical Oncology Department, AUSL-IRCCS Scienze Neurologiche, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Medical Oncology Department, AUSL-IRCCS Scienze Neurologiche, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Clement, Paul M" sort="Clement, Paul M" uniqKey="Clement P" first="Paul M" last="Clement">Paul M. Clement</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, KU Leuven, Leuven, Belgium; Department of General Medical Oncology, UZ Leuven, Leuven Cancer Institute, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Oncology, KU Leuven, Leuven, Belgium; Department of General Medical Oncology, UZ Leuven, Leuven Cancer Institute, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Baurain, Jean Francais" sort="Baurain, Jean Francais" uniqKey="Baurain J" first="Jean Francais" last="Baurain">Jean Francais Baurain</name><affiliation wicri:level="1"><nlm:affiliation>Medical Oncology Department, King Albert II Cancer Institute, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Medical Oncology Department, King Albert II Cancer Institute, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Mason, Warren P" sort="Mason, Warren P" uniqKey="Mason W" first="Warren P" last="Mason">Warren P. Mason</name><affiliation wicri:level="1"><nlm:affiliation>Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Centre, University of Toronto, Toronto, ON</wicri:regionArea></affiliation></author><author><name sortKey="Wheeler, Helen" sort="Wheeler, Helen" uniqKey="Wheeler H" first="Helen" last="Wheeler">Helen Wheeler</name><affiliation wicri:level="1"><nlm:affiliation>Northern Sydney Cancer Centre, North Shore Hospital, St Leonards, NSW, Australia; Department of Medicine, University of Sydney, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Northern Sydney Cancer Centre, North Shore Hospital, St Leonards, NSW, Australia; Department of Medicine, University of Sydney, Sydney, NSW</wicri:regionArea></affiliation></author><author><name sortKey="Chinot, Olivier L" sort="Chinot, Olivier L" uniqKey="Chinot O" first="Olivier L" last="Chinot">Olivier L. Chinot</name><affiliation wicri:level="1"><nlm:affiliation>Neuro-Oncology Division, Aix-Marseille University, AP-HM, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Neuro-Oncology Division, Aix-Marseille University, AP-HM, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Gill, Sanjeev" sort="Gill, Sanjeev" uniqKey="Gill S" first="Sanjeev" last="Gill">Sanjeev Gill</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Alfred Hospital, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Oncology, Alfred Hospital, Melbourne, VIC</wicri:regionArea></affiliation></author><author><name sortKey="Griffin, Matthew" sort="Griffin, Matthew" uniqKey="Griffin M" first="Matthew" last="Griffin">Matthew Griffin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Oncology, Nottingham University Hospitals NHS Trust, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Oncology, Nottingham University Hospitals NHS Trust, Nottingham</wicri:regionArea></affiliation></author><author><name sortKey="Brachman, David G" sort="Brachman, David G" uniqKey="Brachman D" first="David G" last="Brachman">David G. Brachman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Oncology, Barrow Neurological Institute, Phoenix, AZ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Oncology, Barrow Neurological Institute, Phoenix, AZ</wicri:regionArea></affiliation></author><author><name sortKey="Taal, Walter" sort="Taal, Walter" uniqKey="Taal W" first="Walter" last="Taal">Walter Taal</name><affiliation wicri:level="1"><nlm:affiliation>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Ruda, Roberta" sort="Ruda, Roberta" uniqKey="Ruda R" first="Roberta" last="Rudà">Roberta Rudà</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuro-Oncology, City of Health and Science Hospital and University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuro-Oncology, City of Health and Science Hospital and University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Weller, Michael" sort="Weller, Michael" uniqKey="Weller M" first="Michael" last="Weller">Michael Weller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology and Brain Tumour Centre, University Hospital and University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology and Brain Tumour Centre, University Hospital and University of Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Mcbain, Catherine" sort="Mcbain, Catherine" uniqKey="Mcbain C" first="Catherine" last="Mcbain">Catherine Mcbain</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Oncology, Christie NHS Foundation Trust, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Oncology, Christie NHS Foundation Trust, Manchester</wicri:regionArea></affiliation></author><author><name sortKey="Reijneveld, Jaap" sort="Reijneveld, Jaap" uniqKey="Reijneveld J" first="Jaap" last="Reijneveld">Jaap Reijneveld</name><affiliation wicri:level="1"><nlm:affiliation>VUmc Cancer Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Department of Neurology, VU University Medical Centre, Amsterdam, Netherlands; Department of Neurology, Academic Medical Centre, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VUmc Cancer Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Department of Neurology, VU University Medical Centre, Amsterdam, Netherlands; Department of Neurology, Academic Medical Centre, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Enting, Roelien H" sort="Enting, Roelien H" uniqKey="Enting R" first="Roelien H" last="Enting">Roelien H. Enting</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, UMCG, University of Groningen, Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, UMCG, University of Groningen, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Weber, Damien C" sort="Weber, Damien C" uniqKey="Weber D" first="Damien C" last="Weber">Damien C. Weber</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Oncology, University Hospital of Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Radiation Oncology, University Hospital of Geneva, Geneva</wicri:regionArea></affiliation></author><author><name sortKey="Lesimple, Thierry" sort="Lesimple, Thierry" uniqKey="Lesimple T" first="Thierry" last="Lesimple">Thierry Lesimple</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Oncology, Comprehensive Cancer Center Eugène Marquis, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical Oncology, Comprehensive Cancer Center Eugène Marquis, Rennes</wicri:regionArea></affiliation></author><author><name sortKey="Clenton, Susan" sort="Clenton, Susan" uniqKey="Clenton S" first="Susan" last="Clenton">Susan Clenton</name><affiliation wicri:level="1"><nlm:affiliation>Weston Park Hospital, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Weston Park Hospital, Sheffield</wicri:regionArea></affiliation></author><author><name sortKey="Gijtenbeek, Anja" sort="Gijtenbeek, Anja" uniqKey="Gijtenbeek A" first="Anja" last="Gijtenbeek">Anja Gijtenbeek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Radboud University Medical Centre, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Radboud University Medical Centre, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Pascoe, Sarah" sort="Pascoe, Sarah" uniqKey="Pascoe S" first="Sarah" last="Pascoe">Sarah Pascoe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Oncology, Plymouth Hospitals NHS Trust, Plymouth, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Oncology, Plymouth Hospitals NHS Trust, Plymouth</wicri:regionArea></affiliation></author><author><name sortKey="Herrlinger, Ulrich" sort="Herrlinger, Ulrich" uniqKey="Herrlinger U" first="Ulrich" last="Herrlinger">Ulrich Herrlinger</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Neuro-Oncology, Department of Neurology, University of Bonn Medical Centre, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Neuro-Oncology, Department of Neurology, University of Bonn Medical Centre, Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Hau, Peter" sort="Hau, Peter" uniqKey="Hau P" first="Peter" last="Hau">Peter Hau</name><affiliation wicri:level="1"><nlm:affiliation>Wilhelm Sander-Neuro-Oncology Unit and Department of Neurology, University Hospital Regensburg, Regensburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Wilhelm Sander-Neuro-Oncology Unit and Department of Neurology, University Hospital Regensburg, Regensburg</wicri:regionArea></affiliation></author><author><name sortKey="Dhermain, Frederic" sort="Dhermain, Frederic" uniqKey="Dhermain F" first="Frederic" last="Dhermain">Frederic Dhermain</name><affiliation wicri:level="1"><nlm:affiliation>Radiotherapy Department, Gustave Roussy University Hospital, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Radiotherapy Department, Gustave Roussy University Hospital, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Van Heuvel, Irene" sort="Van Heuvel, Irene" uniqKey="Van Heuvel I" first="Irene" last="Van Heuvel">Irene Van Heuvel</name><affiliation wicri:level="1"><nlm:affiliation>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Stupp, Roger" sort="Stupp, Roger" uniqKey="Stupp R" first="Roger" last="Stupp">Roger Stupp</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, University Hospital and University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Oncology, University Hospital and University of Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Aldape, Ken" sort="Aldape, Ken" uniqKey="Aldape K" first="Ken" last="Aldape">Ken Aldape</name><affiliation wicri:level="1"><nlm:affiliation>Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Centre, University of Toronto, Toronto, ON</wicri:regionArea></affiliation></author><author><name sortKey="Jenkins, Robert B" sort="Jenkins, Robert B" uniqKey="Jenkins R" first="Robert B" last="Jenkins">Robert B. Jenkins</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN</wicri:regionArea></affiliation></author><author><name sortKey="Dubbink, Hendrikus Jan" sort="Dubbink, Hendrikus Jan" uniqKey="Dubbink H" first="Hendrikus Jan" last="Dubbink">Hendrikus Jan Dubbink</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Dinjens, Winand N M" sort="Dinjens, Winand N M" uniqKey="Dinjens W" first="Winand N M" last="Dinjens">Winand N M. Dinjens</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Wesseling, Pieter" sort="Wesseling, Pieter" uniqKey="Wesseling P" first="Pieter" last="Wesseling">Pieter Wesseling</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands; Department of Pathology, Radboud University Medical Centre, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands; Department of Pathology, Radboud University Medical Centre, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Nuyens, Sarah" sort="Nuyens, Sarah" uniqKey="Nuyens S" first="Sarah" last="Nuyens">Sarah Nuyens</name><affiliation wicri:level="1"><nlm:affiliation>EORTC, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>EORTC, Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Golfinopoulos, Vassilis" sort="Golfinopoulos, Vassilis" uniqKey="Golfinopoulos V" first="Vassilis" last="Golfinopoulos">Vassilis Golfinopoulos</name><affiliation wicri:level="1"><nlm:affiliation>EORTC, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>EORTC, Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Gorlia, Thierry" sort="Gorlia, Thierry" uniqKey="Gorlia T" first="Thierry" last="Gorlia">Thierry Gorlia</name><affiliation wicri:level="1"><nlm:affiliation>EORTC, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>EORTC, Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Wick, Wolfgang" sort="Wick, Wolfgang" uniqKey="Wick W" first="Wolfgang" last="Wick">Wolfgang Wick</name><affiliation wicri:level="1"><nlm:affiliation>Neurologische Klinik und Nationales Zentrum für Tumorerkrankungen Universitätsklinik, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik und Nationales Zentrum für Tumorerkrankungen Universitätsklinik, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Kros, Johan M" sort="Kros, Johan M" uniqKey="Kros J" first="Johan M" last="Kros">Johan M. Kros</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28801186</idno><idno type="pmid">28801186</idno><idno type="doi">10.1016/S0140-6736(17)31442-3</idno><idno type="wicri:Area/PubMed/Corpus">000417</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000417</idno><idno type="wicri:Area/PubMed/Curation">000415</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000415</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study.</title><author><name sortKey="Van Den Bent, Martin J" sort="Van Den Bent, Martin J" uniqKey="Van Den Bent M" first="Martin J" last="Van Den Bent">Martin J. Van Den Bent</name><affiliation wicri:level="1"><nlm:affiliation>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands. Electronic address: m.vandenbent@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Baumert, Brigitta" sort="Baumert, Brigitta" uniqKey="Baumert B" first="Brigitta" last="Baumert">Brigitta Baumert</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation-Oncology (MAASTRO), Maastricht University Medical Centre (MUMC), Maastricht, Netherlands; GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre (MUMC), Maastricht, Netherlands; Department of Radiation-Oncology, University of Münster, Münster, Germany; Paracelsus Clinic, Osnabrück, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiation-Oncology (MAASTRO), Maastricht University Medical Centre (MUMC), Maastricht, Netherlands; GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre (MUMC), Maastricht, Netherlands; Department of Radiation-Oncology, University of Münster, Münster, Germany; Paracelsus Clinic, Osnabrück</wicri:regionArea></affiliation></author><author><name sortKey="Erridge, Sara C" sort="Erridge, Sara C" uniqKey="Erridge S" first="Sara C" last="Erridge">Sara C. Erridge</name><affiliation wicri:level="1"><nlm:affiliation>Edinburgh Centre for Neuro-Oncology, Western General Hospital, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Edinburgh Centre for Neuro-Oncology, Western General Hospital, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Vogelbaum, Michael A" sort="Vogelbaum, Michael A" uniqKey="Vogelbaum M" first="Michael A" last="Vogelbaum">Michael A. Vogelbaum</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA; Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA; Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH</wicri:regionArea></affiliation></author><author><name sortKey="Nowak, Anna K" sort="Nowak, Anna K" uniqKey="Nowak A" first="Anna K" last="Nowak">Anna K. Nowak</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia; Co-Operative Group for Neuro-Oncology, University of Sydney, Camperdown, NSW, Australia; Department of Medical Oncology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia; Co-Operative Group for Neuro-Oncology, University of Sydney, Camperdown, NSW, Australia; Department of Medical Oncology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA</wicri:regionArea></affiliation></author><author><name sortKey="Sanson, Marc" sort="Sanson, Marc" uniqKey="Sanson M" first="Marc" last="Sanson">Marc Sanson</name><affiliation wicri:level="1"><nlm:affiliation>Sorbonne Universités UPMC, University Paris VI, INSERM, CNRS, APHP, Institut du Cerveau et de la Moelle (ICM), Hôpital Pitié-Salpêtrière, F-75013, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Sorbonne Universités UPMC, University Paris VI, INSERM, CNRS, APHP, Institut du Cerveau et de la Moelle (ICM), Hôpital Pitié-Salpêtrière, F-75013, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Brandes, Alba Ariela" sort="Brandes, Alba Ariela" uniqKey="Brandes A" first="Alba Ariela" last="Brandes">Alba Ariela Brandes</name><affiliation wicri:level="1"><nlm:affiliation>Medical Oncology Department, AUSL-IRCCS Scienze Neurologiche, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Medical Oncology Department, AUSL-IRCCS Scienze Neurologiche, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Clement, Paul M" sort="Clement, Paul M" uniqKey="Clement P" first="Paul M" last="Clement">Paul M. Clement</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, KU Leuven, Leuven, Belgium; Department of General Medical Oncology, UZ Leuven, Leuven Cancer Institute, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Oncology, KU Leuven, Leuven, Belgium; Department of General Medical Oncology, UZ Leuven, Leuven Cancer Institute, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Baurain, Jean Francais" sort="Baurain, Jean Francais" uniqKey="Baurain J" first="Jean Francais" last="Baurain">Jean Francais Baurain</name><affiliation wicri:level="1"><nlm:affiliation>Medical Oncology Department, King Albert II Cancer Institute, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Medical Oncology Department, King Albert II Cancer Institute, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Mason, Warren P" sort="Mason, Warren P" uniqKey="Mason W" first="Warren P" last="Mason">Warren P. Mason</name><affiliation wicri:level="1"><nlm:affiliation>Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Centre, University of Toronto, Toronto, ON</wicri:regionArea></affiliation></author><author><name sortKey="Wheeler, Helen" sort="Wheeler, Helen" uniqKey="Wheeler H" first="Helen" last="Wheeler">Helen Wheeler</name><affiliation wicri:level="1"><nlm:affiliation>Northern Sydney Cancer Centre, North Shore Hospital, St Leonards, NSW, Australia; Department of Medicine, University of Sydney, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Northern Sydney Cancer Centre, North Shore Hospital, St Leonards, NSW, Australia; Department of Medicine, University of Sydney, Sydney, NSW</wicri:regionArea></affiliation></author><author><name sortKey="Chinot, Olivier L" sort="Chinot, Olivier L" uniqKey="Chinot O" first="Olivier L" last="Chinot">Olivier L. Chinot</name><affiliation wicri:level="1"><nlm:affiliation>Neuro-Oncology Division, Aix-Marseille University, AP-HM, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Neuro-Oncology Division, Aix-Marseille University, AP-HM, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Gill, Sanjeev" sort="Gill, Sanjeev" uniqKey="Gill S" first="Sanjeev" last="Gill">Sanjeev Gill</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Alfred Hospital, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Oncology, Alfred Hospital, Melbourne, VIC</wicri:regionArea></affiliation></author><author><name sortKey="Griffin, Matthew" sort="Griffin, Matthew" uniqKey="Griffin M" first="Matthew" last="Griffin">Matthew Griffin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Oncology, Nottingham University Hospitals NHS Trust, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Oncology, Nottingham University Hospitals NHS Trust, Nottingham</wicri:regionArea></affiliation></author><author><name sortKey="Brachman, David G" sort="Brachman, David G" uniqKey="Brachman D" first="David G" last="Brachman">David G. Brachman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Oncology, Barrow Neurological Institute, Phoenix, AZ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Oncology, Barrow Neurological Institute, Phoenix, AZ</wicri:regionArea></affiliation></author><author><name sortKey="Taal, Walter" sort="Taal, Walter" uniqKey="Taal W" first="Walter" last="Taal">Walter Taal</name><affiliation wicri:level="1"><nlm:affiliation>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Ruda, Roberta" sort="Ruda, Roberta" uniqKey="Ruda R" first="Roberta" last="Rudà">Roberta Rudà</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuro-Oncology, City of Health and Science Hospital and University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuro-Oncology, City of Health and Science Hospital and University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Weller, Michael" sort="Weller, Michael" uniqKey="Weller M" first="Michael" last="Weller">Michael Weller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology and Brain Tumour Centre, University Hospital and University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology and Brain Tumour Centre, University Hospital and University of Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Mcbain, Catherine" sort="Mcbain, Catherine" uniqKey="Mcbain C" first="Catherine" last="Mcbain">Catherine Mcbain</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Oncology, Christie NHS Foundation Trust, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Oncology, Christie NHS Foundation Trust, Manchester</wicri:regionArea></affiliation></author><author><name sortKey="Reijneveld, Jaap" sort="Reijneveld, Jaap" uniqKey="Reijneveld J" first="Jaap" last="Reijneveld">Jaap Reijneveld</name><affiliation wicri:level="1"><nlm:affiliation>VUmc Cancer Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Department of Neurology, VU University Medical Centre, Amsterdam, Netherlands; Department of Neurology, Academic Medical Centre, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VUmc Cancer Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Department of Neurology, VU University Medical Centre, Amsterdam, Netherlands; Department of Neurology, Academic Medical Centre, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Enting, Roelien H" sort="Enting, Roelien H" uniqKey="Enting R" first="Roelien H" last="Enting">Roelien H. Enting</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, UMCG, University of Groningen, Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, UMCG, University of Groningen, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Weber, Damien C" sort="Weber, Damien C" uniqKey="Weber D" first="Damien C" last="Weber">Damien C. Weber</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Oncology, University Hospital of Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Radiation Oncology, University Hospital of Geneva, Geneva</wicri:regionArea></affiliation></author><author><name sortKey="Lesimple, Thierry" sort="Lesimple, Thierry" uniqKey="Lesimple T" first="Thierry" last="Lesimple">Thierry Lesimple</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Oncology, Comprehensive Cancer Center Eugène Marquis, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical Oncology, Comprehensive Cancer Center Eugène Marquis, Rennes</wicri:regionArea></affiliation></author><author><name sortKey="Clenton, Susan" sort="Clenton, Susan" uniqKey="Clenton S" first="Susan" last="Clenton">Susan Clenton</name><affiliation wicri:level="1"><nlm:affiliation>Weston Park Hospital, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Weston Park Hospital, Sheffield</wicri:regionArea></affiliation></author><author><name sortKey="Gijtenbeek, Anja" sort="Gijtenbeek, Anja" uniqKey="Gijtenbeek A" first="Anja" last="Gijtenbeek">Anja Gijtenbeek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Radboud University Medical Centre, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Radboud University Medical Centre, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Pascoe, Sarah" sort="Pascoe, Sarah" uniqKey="Pascoe S" first="Sarah" last="Pascoe">Sarah Pascoe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Oncology, Plymouth Hospitals NHS Trust, Plymouth, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Oncology, Plymouth Hospitals NHS Trust, Plymouth</wicri:regionArea></affiliation></author><author><name sortKey="Herrlinger, Ulrich" sort="Herrlinger, Ulrich" uniqKey="Herrlinger U" first="Ulrich" last="Herrlinger">Ulrich Herrlinger</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Neuro-Oncology, Department of Neurology, University of Bonn Medical Centre, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Neuro-Oncology, Department of Neurology, University of Bonn Medical Centre, Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Hau, Peter" sort="Hau, Peter" uniqKey="Hau P" first="Peter" last="Hau">Peter Hau</name><affiliation wicri:level="1"><nlm:affiliation>Wilhelm Sander-Neuro-Oncology Unit and Department of Neurology, University Hospital Regensburg, Regensburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Wilhelm Sander-Neuro-Oncology Unit and Department of Neurology, University Hospital Regensburg, Regensburg</wicri:regionArea></affiliation></author><author><name sortKey="Dhermain, Frederic" sort="Dhermain, Frederic" uniqKey="Dhermain F" first="Frederic" last="Dhermain">Frederic Dhermain</name><affiliation wicri:level="1"><nlm:affiliation>Radiotherapy Department, Gustave Roussy University Hospital, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Radiotherapy Department, Gustave Roussy University Hospital, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Van Heuvel, Irene" sort="Van Heuvel, Irene" uniqKey="Van Heuvel I" first="Irene" last="Van Heuvel">Irene Van Heuvel</name><affiliation wicri:level="1"><nlm:affiliation>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Stupp, Roger" sort="Stupp, Roger" uniqKey="Stupp R" first="Roger" last="Stupp">Roger Stupp</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, University Hospital and University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Oncology, University Hospital and University of Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Aldape, Ken" sort="Aldape, Ken" uniqKey="Aldape K" first="Ken" last="Aldape">Ken Aldape</name><affiliation wicri:level="1"><nlm:affiliation>Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Centre, University of Toronto, Toronto, ON</wicri:regionArea></affiliation></author><author><name sortKey="Jenkins, Robert B" sort="Jenkins, Robert B" uniqKey="Jenkins R" first="Robert B" last="Jenkins">Robert B. Jenkins</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN</wicri:regionArea></affiliation></author><author><name sortKey="Dubbink, Hendrikus Jan" sort="Dubbink, Hendrikus Jan" uniqKey="Dubbink H" first="Hendrikus Jan" last="Dubbink">Hendrikus Jan Dubbink</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Dinjens, Winand N M" sort="Dinjens, Winand N M" uniqKey="Dinjens W" first="Winand N M" last="Dinjens">Winand N M. Dinjens</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Wesseling, Pieter" sort="Wesseling, Pieter" uniqKey="Wesseling P" first="Pieter" last="Wesseling">Pieter Wesseling</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands; Department of Pathology, Radboud University Medical Centre, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands; Department of Pathology, Radboud University Medical Centre, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Nuyens, Sarah" sort="Nuyens, Sarah" uniqKey="Nuyens S" first="Sarah" last="Nuyens">Sarah Nuyens</name><affiliation wicri:level="1"><nlm:affiliation>EORTC, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>EORTC, Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Golfinopoulos, Vassilis" sort="Golfinopoulos, Vassilis" uniqKey="Golfinopoulos V" first="Vassilis" last="Golfinopoulos">Vassilis Golfinopoulos</name><affiliation wicri:level="1"><nlm:affiliation>EORTC, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>EORTC, Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Gorlia, Thierry" sort="Gorlia, Thierry" uniqKey="Gorlia T" first="Thierry" last="Gorlia">Thierry Gorlia</name><affiliation wicri:level="1"><nlm:affiliation>EORTC, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>EORTC, Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Wick, Wolfgang" sort="Wick, Wolfgang" uniqKey="Wick W" first="Wolfgang" last="Wick">Wolfgang Wick</name><affiliation wicri:level="1"><nlm:affiliation>Neurologische Klinik und Nationales Zentrum für Tumorerkrankungen Universitätsklinik, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik und Nationales Zentrum für Tumorerkrankungen Universitätsklinik, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Kros, Johan M" sort="Kros, Johan M" uniqKey="Kros J" first="Johan M" last="Kros">Johan M. Kros</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The role of temozolomide chemotherapy in newly diagnosed 1p/19q non-co-deleted anaplastic gliomas, which are associated with lower sensitivity to chemotherapy and worse prognosis than 1p/19q co-deleted tumours, is unclear. We assessed the use of radiotherapy with concurrent and adjuvant temozolomide in adults with non-co-deleted anaplastic gliomas.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">28801186</PMID><DateCreated><Year>2017</Year><Month>08</Month><Day>12</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-547X</ISSN><JournalIssue CitedMedium="Internet"><Volume>390</Volume><Issue>10103</Issue><PubDate><Year>2017</Year><Month>Oct</Month><Day>07</Day></PubDate></JournalIssue><Title>Lancet (London, England)</Title><ISOAbbreviation>Lancet</ISOAbbreviation></Journal><ArticleTitle>Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study.</ArticleTitle><Pagination><MedlinePgn>1645-1653</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0140-6736(17)31442-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/S0140-6736(17)31442-3</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The role of temozolomide chemotherapy in newly diagnosed 1p/19q non-co-deleted anaplastic gliomas, which are associated with lower sensitivity to chemotherapy and worse prognosis than 1p/19q co-deleted tumours, is unclear. We assessed the use of radiotherapy with concurrent and adjuvant temozolomide in adults with non-co-deleted anaplastic gliomas.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">This was a phase 3, randomised, open-label study with a 2 × 2 factorial design. Eligible patients were aged 18 years or older and had newly diagnosed non-co-deleted anaplastic glioma with WHO performance status scores of 0-2. The randomisation schedule was generated with the electronic EORTC web-based ORTA system. Patients were assigned in equal numbers (1:1:1:1), using the minimisation technique, to receive radiotherapy (59·4 Gy in 33 fractions of 1·8 Gy) alone or with adjuvant temozolomide (12 4-week cycles of 150-200 mg/m(2) temozolomide given on days 1-5); or to receive radiotherapy with concurrent temozolomide 75 mg/m(2) per day, with or without adjuvant temozolomide. The primary endpoint was overall survival adjusted for performance status score, age, 1p loss of heterozygosity, presence of oligodendroglial elements, and MGMT promoter methylation status, analysed by intention to treat. We did a planned interim analysis after 219 (41%) deaths had occurred to test the null hypothesis of no efficacy (threshold for rejection p<0·0084). This trial is registered with ClinicalTrials.gov, number NCT00626990.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">At the time of the interim analysis, 745 (99%) of the planned 748 patients had been enrolled. The hazard ratio for overall survival with use of adjuvant temozolomide was 0·65 (99·145% CI 0·45-0·93). Overall survival at 5 years was 55·9% (95% CI 47·2-63·8) with and 44·1% (36·3-51·6) without adjuvant temozolomide. Grade 3-4 adverse events were seen in 8-12% of 549 patients assigned temozolomide, and were mainly haematological and reversible.</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Adjuvant temozolomide chemotherapy was associated with a significant survival benefit in patients with newly diagnosed non-co-deleted anaplastic glioma. Further analysis of the role of concurrent temozolomide treatment and molecular factors is needed.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">Schering Plough and MSD.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>van den Bent</LastName><ForeName>Martin J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands. Electronic address: m.vandenbent@erasmusmc.nl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baumert</LastName><ForeName>Brigitta</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Radiation-Oncology (MAASTRO), Maastricht University Medical Centre (MUMC), Maastricht, Netherlands; GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre (MUMC), Maastricht, Netherlands; Department of Radiation-Oncology, University of Münster, Münster, Germany; Paracelsus Clinic, Osnabrück, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Erridge</LastName><ForeName>Sara C</ForeName><Initials>SC</Initials><AffiliationInfo><Affiliation>Edinburgh Centre for Neuro-Oncology, Western General Hospital, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vogelbaum</LastName><ForeName>Michael A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA; Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nowak</LastName><ForeName>Anna K</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia; Co-Operative Group for Neuro-Oncology, University of Sydney, Camperdown, NSW, Australia; Department of Medical Oncology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sanson</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Sorbonne Universités UPMC, University Paris VI, INSERM, CNRS, APHP, Institut du Cerveau et de la Moelle (ICM), Hôpital Pitié-Salpêtrière, F-75013, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brandes</LastName><ForeName>Alba Ariela</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Medical Oncology Department, AUSL-IRCCS Scienze Neurologiche, Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clement</LastName><ForeName>Paul M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Department of Oncology, KU Leuven, Leuven, Belgium; Department of General Medical Oncology, UZ Leuven, Leuven Cancer Institute, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baurain</LastName><ForeName>Jean Francais</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Medical Oncology Department, King Albert II Cancer Institute, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mason</LastName><ForeName>Warren P</ForeName><Initials>WP</Initials><AffiliationInfo><Affiliation>Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wheeler</LastName><ForeName>Helen</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Northern Sydney Cancer Centre, North Shore Hospital, St Leonards, NSW, Australia; Department of Medicine, University of Sydney, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chinot</LastName><ForeName>Olivier L</ForeName><Initials>OL</Initials><AffiliationInfo><Affiliation>Neuro-Oncology Division, Aix-Marseille University, AP-HM, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gill</LastName><ForeName>Sanjeev</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Alfred Hospital, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Griffin</LastName><ForeName>Matthew</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Clinical Oncology, Nottingham University Hospitals NHS Trust, Nottingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brachman</LastName><ForeName>David G</ForeName><Initials>DG</Initials><AffiliationInfo><Affiliation>Department of Radiation Oncology, Barrow Neurological Institute, Phoenix, AZ, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taal</LastName><ForeName>Walter</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rudà</LastName><ForeName>Roberta</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neuro-Oncology, City of Health and Science Hospital and University of Turin, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weller</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology and Brain Tumour Centre, University Hospital and University of Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McBain</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Clinical Oncology, Christie NHS Foundation Trust, Manchester, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reijneveld</LastName><ForeName>Jaap</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>VUmc Cancer Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Department of Neurology, VU University Medical Centre, Amsterdam, Netherlands; Department of Neurology, Academic Medical Centre, Amsterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Enting</LastName><ForeName>Roelien H</ForeName><Initials>RH</Initials><AffiliationInfo><Affiliation>Department of Neurology, UMCG, University of Groningen, Groningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weber</LastName><ForeName>Damien C</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>Department of Radiation Oncology, University Hospital of Geneva, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lesimple</LastName><ForeName>Thierry</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Clinical Oncology, Comprehensive Cancer Center Eugène Marquis, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clenton</LastName><ForeName>Susan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Weston Park Hospital, Sheffield, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gijtenbeek</LastName><ForeName>Anja</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, Radboud University Medical Centre, Nijmegen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pascoe</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Clinical Oncology, Plymouth Hospitals NHS Trust, Plymouth, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herrlinger</LastName><ForeName>Ulrich</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Division of Clinical Neuro-Oncology, Department of Neurology, University of Bonn Medical Centre, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hau</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Wilhelm Sander-Neuro-Oncology Unit and Department of Neurology, University Hospital Regensburg, Regensburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dhermain</LastName><ForeName>Frederic</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Radiotherapy Department, Gustave Roussy University Hospital, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Heuvel</LastName><ForeName>Irene</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stupp</LastName><ForeName>Roger</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, University Hospital and University of Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aldape</LastName><ForeName>Ken</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jenkins</LastName><ForeName>Robert B</ForeName><Initials>RB</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dubbink</LastName><ForeName>Hendrikus Jan</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dinjens</LastName><ForeName>Winand N M</ForeName><Initials>WNM</Initials><AffiliationInfo><Affiliation>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wesseling</LastName><ForeName>Pieter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands; Department of Pathology, Radboud University Medical Centre, Nijmegen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nuyens</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>EORTC, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Golfinopoulos</LastName><ForeName>Vassilis</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>EORTC, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gorlia</LastName><ForeName>Thierry</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>EORTC, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wick</LastName><ForeName>Wolfgang</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Neurologische Klinik und Nationales Zentrum für Tumorerkrankungen Universitätsklinik, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kros</LastName><ForeName>Johan M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>08</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lancet</MedlineTA><NlmUniqueID>2985213R</NlmUniqueID><ISSNLinking>0140-6736</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>02</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>03</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>03</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>8</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>8</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>8</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28801186</ArticleId><ArticleId IdType="pii">S0140-6736(17)31442-3</ArticleId><ArticleId IdType="doi">10.1016/S0140-6736(17)31442-3</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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