Safety and acceptability of transcranial direct current stimulation for the acute treatment of major depressive episodes: Analysis of individual patient data.
Identifieur interne : 000309 ( PubMed/Curation ); précédent : 000308; suivant : 000310Safety and acceptability of transcranial direct current stimulation for the acute treatment of major depressive episodes: Analysis of individual patient data.
Auteurs : Adriano H. Moffa [Brésil] ; André R. Brunoni [Brésil] ; Felipe Fregni [États-Unis] ; Ulrich Palm [Allemagne] ; Frank Padberg [Allemagne] ; Daniel M. Blumberger [Canada] ; Zafiris J. Daskalakis [Canada] ; Djamila Bennabi [France] ; Emmanuel Haffen [France] ; Angelo Alonzo [Australie] ; Colleen K. Loo [Australie]Source :
- Journal of affective disorders [ 1573-2517 ] ; 2017.
Abstract
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation modality that has been increasingly used for major depressive disorder (MDD) treatment. Although studies in healthy volunteers showed that the technique is well-tolerated, tDCS safety and acceptability have not been sufficiently explored in patients with MDD.
DOI: 10.1016/j.jad.2017.06.021
PubMed: 28623732
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<front><div type="abstract" xml:lang="en">Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation modality that has been increasingly used for major depressive disorder (MDD) treatment. Although studies in healthy volunteers showed that the technique is well-tolerated, tDCS safety and acceptability have not been sufficiently explored in patients with MDD.</div>
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<DateCreated><Year>2017</Year>
<Month>06</Month>
<Day>17</Day>
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<DateRevised><Year>2017</Year>
<Month>07</Month>
<Day>16</Day>
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<PubDate><Year>2017</Year>
<Month>Oct</Month>
<Day>15</Day>
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<Title>Journal of affective disorders</Title>
<ISOAbbreviation>J Affect Disord</ISOAbbreviation>
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<ArticleTitle>Safety and acceptability of transcranial direct current stimulation for the acute treatment of major depressive episodes: Analysis of individual patient data.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation modality that has been increasingly used for major depressive disorder (MDD) treatment. Although studies in healthy volunteers showed that the technique is well-tolerated, tDCS safety and acceptability have not been sufficiently explored in patients with MDD.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We collected individual patient data from 6 randomized clinical trials that had been previously identified in a systematic review and meta-analysis. Primary outcomes were safety (rate of adverse events) and acceptability (rate of dropouts). Secondary outcomes were clinical, demographic and treatment predictors of the primary outcomes.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Dropout rates between active (8.8%) and sham (12%) groups were not significantly different (OR= 0.7, p=0.38). Adverse event rates between active (73.5%) and sham (68.3%) groups were not significantly different (OR= 1.4, p= 0.23). Higher current densities were associated with lower adverse event rates.</AbstractText>
<AbstractText Label="LIMITATIONS" NlmCategory="CONCLUSIONS">Dropout reasons were not systematically reported and adverse events were not collected using questionnaires standardized across studies.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Active tDCS is as acceptable and safe as sham tDCS, as found in randomized clinical trials of MDD.</AbstractText>
<CopyrightInformation>Copyright © 2017. Published by Elsevier B.V.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Moffa</LastName>
<ForeName>Adriano H</ForeName>
<Initials>AH</Initials>
<AffiliationInfo><Affiliation>Interdisciplinary Center for Applied Neuromodulation, University Hospital & Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, Laboratory of Neurosciences (LIM-27), University of São Paulo, São Paulo, Brazil.</Affiliation>
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<Author ValidYN="Y"><LastName>Fregni</LastName>
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</AffiliationInfo>
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</AffiliationInfo>
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<AffiliationInfo><Affiliation>Department of Clinical Psychiatry, Clinical Investigation Center 1431 Inserm, EA 481 Neurosciences, University Hospital of Besancon and FondaMental Foundation, Créteil, France.</Affiliation>
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<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Psychiatry, Clinical Investigation Center 1431 Inserm, EA 481 Neurosciences, University Hospital of Besancon and FondaMental Foundation, Créteil, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alonzo</LastName>
<ForeName>Angelo</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Black Dog Institute & School of Psychiatry, University of New South Wales, Sydney, Australia.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Loo</LastName>
<ForeName>Colleen K</ForeName>
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<AffiliationInfo><Affiliation>Black Dog Institute & School of Psychiatry, University of New South Wales, Sydney, Australia.</Affiliation>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Acceptability</Keyword>
<Keyword MajorTopicYN="N">Adverse effects</Keyword>
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