Replication and Excretion of the Live Attenuated Tetravalent Dengue Vaccine CYD-TDV in a Flavivirus-Naive Adult Population: Assessment of Vaccine Viremia and Virus Shedding.
Identifieur interne : 000273 ( PubMed/Curation ); précédent : 000272; suivant : 000274Replication and Excretion of the Live Attenuated Tetravalent Dengue Vaccine CYD-TDV in a Flavivirus-Naive Adult Population: Assessment of Vaccine Viremia and Virus Shedding.
Auteurs : Joseph Torresi [Australie] ; Peter C. Richmond ; Leon G. Heron ; Ming Qiao ; Joanne Marjason [Australie] ; Linda Starr-Spires [États-Unis] ; Diane Van Der Vliet [France] ; Jing Jin [République populaire de Chine] ; T Anh Wartel [Singapour] ; Alain Bouckenooghe [Singapour]Source :
- The Journal of infectious diseases [ 1537-6613 ] ; 2017.
Abstract
We assessed replication and excretion of the live attenuated tetravalent dengue vaccine (CYD-TDV) into biological fluids following vaccination in dengue-naive adults in Australia.
DOI: 10.1093/infdis/jix314
PubMed: 28968794
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Peter C. Richmond<affiliation><nlm:affiliation>University of Western Australia School of Paediatrics and Child Health.</nlm:affiliation><wicri:noCountry code="no comma">University of Western Australia School of Paediatrics and Child Health.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, Children's Hospital at Westmead, Westmead.</nlm:affiliation><wicri:noCountry code="subField">Westmead</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Royal Adelaide Hospital.</nlm:affiliation><wicri:noCountry code="no comma">Royal Adelaide Hospital.</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Replication and Excretion of the Live Attenuated Tetravalent Dengue Vaccine CYD-TDV in a Flavivirus-Naive Adult Population: Assessment of Vaccine Viremia and Virus Shedding.</title><author><name sortKey="Torresi, Joseph" sort="Torresi, Joseph" uniqKey="Torresi J" first="Joseph" last="Torresi">Joseph Torresi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne.</nlm:affiliation><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><wicri:orgArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne</wicri:orgArea></affiliation></author><author><name sortKey="Richmond, Peter C" sort="Richmond, Peter C" uniqKey="Richmond P" first="Peter C" last="Richmond">Peter C. Richmond</name><affiliation><nlm:affiliation>University of Western Australia School of Paediatrics and Child Health.</nlm:affiliation><wicri:noCountry code="no comma">University of Western Australia School of Paediatrics and Child Health.</wicri:noCountry></affiliation></author><author><name sortKey="Heron, Leon G" sort="Heron, Leon G" uniqKey="Heron L" first="Leon G" last="Heron">Leon G. Heron</name><affiliation><nlm:affiliation>National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, Children's Hospital at Westmead, Westmead.</nlm:affiliation><wicri:noCountry code="subField">Westmead</wicri:noCountry></affiliation></author><author><name sortKey="Qiao, Ming" sort="Qiao, Ming" uniqKey="Qiao M" first="Ming" last="Qiao">Ming Qiao</name><affiliation><nlm:affiliation>Royal Adelaide Hospital.</nlm:affiliation><wicri:noCountry code="no comma">Royal Adelaide Hospital.</wicri:noCountry></affiliation></author><author><name sortKey="Marjason, Joanne" sort="Marjason, Joanne" uniqKey="Marjason J" first="Joanne" last="Marjason">Joanne Marjason</name><affiliation wicri:level="1"><nlm:affiliation>Q-Pharm, Herston, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Q-Pharm, Herston</wicri:regionArea></affiliation></author><author><name sortKey="Starr Spires, Linda" sort="Starr Spires, Linda" uniqKey="Starr Spires L" first="Linda" last="Starr-Spires">Linda Starr-Spires</name><affiliation wicri:level="2"><nlm:affiliation>Global Clinical Immunology, Sanofi Pasteur, Swiftwater, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Global Clinical Immunology, Sanofi Pasteur, Swiftwater</wicri:cityArea></affiliation></author><author><name sortKey="Van Der Vliet, Diane" sort="Van Der Vliet, Diane" uniqKey="Van Der Vliet D" first="Diane" last="Van Der Vliet">Diane Van Der Vliet</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Development, Sanofi Pasteur, Marcy l'Etoile, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Clinical Development, Sanofi Pasteur, Marcy l'Etoile</wicri:regionArea></affiliation></author><author><name sortKey="Jin, Jing" sort="Jin, Jing" uniqKey="Jin J" first="Jing" last="Jin">Jing Jin</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Sciences and Operations, Sanofi, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Clinical Sciences and Operations, Sanofi, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Wartel, T Anh" sort="Wartel, T Anh" uniqKey="Wartel T" first="T Anh" last="Wartel">T Anh Wartel</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Sciences, Sanofi Pasteur, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Clinical Sciences, Sanofi Pasteur</wicri:regionArea></affiliation></author><author><name sortKey="Bouckenooghe, Alain" sort="Bouckenooghe, Alain" uniqKey="Bouckenooghe A" first="Alain" last="Bouckenooghe">Alain Bouckenooghe</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Sciences, Sanofi Pasteur, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Clinical Sciences, Sanofi Pasteur</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28968794</idno><idno type="pmid">28968794</idno><idno type="doi">10.1093/infdis/jix314</idno><idno type="wicri:Area/PubMed/Corpus">000275</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000275</idno><idno type="wicri:Area/PubMed/Curation">000273</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000273</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Replication and Excretion of the Live Attenuated Tetravalent Dengue Vaccine CYD-TDV in a Flavivirus-Naive Adult Population: Assessment of Vaccine Viremia and Virus Shedding.</title><author><name sortKey="Torresi, Joseph" sort="Torresi, Joseph" uniqKey="Torresi J" first="Joseph" last="Torresi">Joseph Torresi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne.</nlm:affiliation><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><wicri:orgArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne</wicri:orgArea></affiliation></author><author><name sortKey="Richmond, Peter C" sort="Richmond, Peter C" uniqKey="Richmond P" first="Peter C" last="Richmond">Peter C. Richmond</name><affiliation><nlm:affiliation>University of Western Australia School of Paediatrics and Child Health.</nlm:affiliation><wicri:noCountry code="no comma">University of Western Australia School of Paediatrics and Child Health.</wicri:noCountry></affiliation></author><author><name sortKey="Heron, Leon G" sort="Heron, Leon G" uniqKey="Heron L" first="Leon G" last="Heron">Leon G. Heron</name><affiliation><nlm:affiliation>National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, Children's Hospital at Westmead, Westmead.</nlm:affiliation><wicri:noCountry code="subField">Westmead</wicri:noCountry></affiliation></author><author><name sortKey="Qiao, Ming" sort="Qiao, Ming" uniqKey="Qiao M" first="Ming" last="Qiao">Ming Qiao</name><affiliation><nlm:affiliation>Royal Adelaide Hospital.</nlm:affiliation><wicri:noCountry code="no comma">Royal Adelaide Hospital.</wicri:noCountry></affiliation></author><author><name sortKey="Marjason, Joanne" sort="Marjason, Joanne" uniqKey="Marjason J" first="Joanne" last="Marjason">Joanne Marjason</name><affiliation wicri:level="1"><nlm:affiliation>Q-Pharm, Herston, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Q-Pharm, Herston</wicri:regionArea></affiliation></author><author><name sortKey="Starr Spires, Linda" sort="Starr Spires, Linda" uniqKey="Starr Spires L" first="Linda" last="Starr-Spires">Linda Starr-Spires</name><affiliation wicri:level="2"><nlm:affiliation>Global Clinical Immunology, Sanofi Pasteur, Swiftwater, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Global Clinical Immunology, Sanofi Pasteur, Swiftwater</wicri:cityArea></affiliation></author><author><name sortKey="Van Der Vliet, Diane" sort="Van Der Vliet, Diane" uniqKey="Van Der Vliet D" first="Diane" last="Van Der Vliet">Diane Van Der Vliet</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Development, Sanofi Pasteur, Marcy l'Etoile, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Clinical Development, Sanofi Pasteur, Marcy l'Etoile</wicri:regionArea></affiliation></author><author><name sortKey="Jin, Jing" sort="Jin, Jing" uniqKey="Jin J" first="Jing" last="Jin">Jing Jin</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Sciences and Operations, Sanofi, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Clinical Sciences and Operations, Sanofi, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Wartel, T Anh" sort="Wartel, T Anh" uniqKey="Wartel T" first="T Anh" last="Wartel">T Anh Wartel</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Sciences, Sanofi Pasteur, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Clinical Sciences, Sanofi Pasteur</wicri:regionArea></affiliation></author><author><name sortKey="Bouckenooghe, Alain" sort="Bouckenooghe, Alain" uniqKey="Bouckenooghe A" first="Alain" last="Bouckenooghe">Alain Bouckenooghe</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Sciences, Sanofi Pasteur, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Clinical Sciences, Sanofi Pasteur</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="eISSN">1537-6613</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We assessed replication and excretion of the live attenuated tetravalent dengue vaccine (CYD-TDV) into biological fluids following vaccination in dengue-naive adults in Australia.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28968794</PMID><DateCreated><Year>2017</Year><Month>10</Month><Day>02</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>03</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1537-6613</ISSN><JournalIssue CitedMedium="Internet"><Volume>216</Volume><Issue>7</Issue><PubDate><Year>2017</Year><Month>Oct</Month><Day>17</Day></PubDate></JournalIssue><Title>The Journal of infectious diseases</Title><ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Replication and Excretion of the Live Attenuated Tetravalent Dengue Vaccine CYD-TDV in a Flavivirus-Naive Adult Population: Assessment of Vaccine Viremia and Virus Shedding.</ArticleTitle><Pagination><MedlinePgn>834-841</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/infdis/jix314</ELocationID><Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">We assessed replication and excretion of the live attenuated tetravalent dengue vaccine (CYD-TDV) into biological fluids following vaccination in dengue-naive adults in Australia.</AbstractText><AbstractText Label="Methods" NlmCategory="UNASSIGNED">Vaccinal viremia/shedding was assessed in a subset of participants enrolled in a lot-to-lot consistency study; 95 participants received 3 subcutaneous doses of CYD-TDV from phase 2/3 lots of the vaccine, and 8 received placebo; doses were administered 6 months apart. Quantitative reverse-transcription polymerase chain reaction (qR-PCR) analysis was used to initially detect the yellow fever virus (YFV) core protein gene in the backbone of CYD-TDV in serum, saliva and urine, followed by serotype-specific qRT-PCR analysis of samples positive for YFV by qRT-PCR (lower limit of detection, 5.16 GEq/mL).</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">YFV viremia was detected by qRT-PCR in 69.5% of participants (66 of 95) who received CYD-TDV, mainly 6-14 days after injection 1. The serotypes detected were serotype 4 (in 68.2% of participants [45 of 95]), serotype 3 (in 19.7% [13 of 95]), and serotype 1 (in 12.1% [8 of 95]); serotype 2 was not detected. None of the placebo recipients had vaccinal viremia/shedding. No participants had detectable viral shedding into saliva at levels above the lower limit of quantitation. Two participants had low-level viral shedding (serotype 3) in urine (5.47 and 5.77 GEq/mL). None of the participants with viremia or shedding experienced concomitant fever.</AbstractText><AbstractText Label="Conclusions" NlmCategory="UNASSIGNED">Low-level vaccinal viremia may occur following vaccination with CYD-TDV, but this is not associated with any symptom or adverse event.</AbstractText><AbstractText Label="Clinical Trials Registration" NlmCategory="UNASSIGNED">NCT01134263.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Torresi</LastName><ForeName>Joseph</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Infectious Diseases, Austin Hospital, Heidelberg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richmond</LastName><ForeName>Peter C</ForeName><Initials>PC</Initials><AffiliationInfo><Affiliation>University of Western Australia School of Paediatrics and Child Health.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Vaccine Trials Group, Telethon Kids Institute, Subiaco.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heron</LastName><ForeName>Leon G</ForeName><Initials>LG</Initials><AffiliationInfo><Affiliation>National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, Children's Hospital at Westmead, Westmead.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qiao</LastName><ForeName>Ming</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Royal Adelaide Hospital.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>SA Pathology, Adelaide.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marjason</LastName><ForeName>Joanne</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Q-Pharm, Herston, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Starr-Spires</LastName><ForeName>Linda</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Global Clinical Immunology, Sanofi Pasteur, Swiftwater, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Vliet</LastName><ForeName>Diane</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Clinical Development, Sanofi Pasteur, Marcy l'Etoile, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Clinical Sciences and Operations, Sanofi, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wartel</LastName><ForeName>T Anh</ForeName><Initials>TA</Initials><AffiliationInfo><Affiliation>Clinical Sciences, Sanofi Pasteur, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouckenooghe</LastName><ForeName>Alain</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Clinical Sciences, Sanofi Pasteur, Singapore.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Infect Dis</MedlineTA><NlmUniqueID>0413675</NlmUniqueID><ISSNLinking>0022-1899</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Flavivirus</Keyword><Keyword MajorTopicYN="N">dengue</Keyword><Keyword MajorTopicYN="N">shedding</Keyword><Keyword MajorTopicYN="N">vaccine</Keyword><Keyword MajorTopicYN="N">viremia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>03</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>08</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>10</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>10</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28968794</ArticleId><ArticleId IdType="pii">4158083</ArticleId><ArticleId IdType="doi">10.1093/infdis/jix314</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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