Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies.
Identifieur interne : 000260 ( PubMed/Curation ); précédent : 000259; suivant : 000261Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies.
Auteurs : Jason H Y. Wu [Australie] ; Matti Marklund [Suède] ; Fumiaki Imamura [Royaume-Uni] ; Nathan Tintle [États-Unis] ; Andres V. Ardisson Korat [États-Unis] ; Janette De Goede [Pays-Bas] ; Xia Zhou [États-Unis] ; Wei-Sin Yang [Taïwan] ; Marcia C. De Oliveira Otto [États-Unis] ; Janine Kröger [Allemagne] ; Waqas Qureshi [États-Unis] ; Jyrki K. Virtanen [Finlande] ; Julie K. Bassett [Australie] ; Alexis C. Frazier-Wood [États-Unis] ; Maria Lankinen [Finlande] ; Rachel A. Murphy [Canada] ; Kalina Rajaobelina [France] ; Liana C. Del Gobbo [États-Unis] ; Nita G. Forouhi [Royaume-Uni] ; Robert Luben [Royaume-Uni] ; Kay-Tee Khaw [États-Unis] ; Nick Wareham [Royaume-Uni] ; Anya Kalsbeek [États-Unis] ; Jenna Veenstra [États-Unis] ; Juhua Luo [États-Unis] ; Frank B. Hu [États-Unis] ; Hung-Ju Lin [Taïwan] ; David S. Siscovick [États-Unis] ; Heiner Boeing [Allemagne] ; Tzu-An Chen [États-Unis] ; Brian Steffen [États-Unis] ; Lyn M. Steffen [États-Unis] ; Allison Hodge [Australie] ; Gudny Eriksdottir [Islande] ; Albert V. Smith [Islande] ; Vilmunder Gudnason [Islande] ; Tamara B. Harris [États-Unis] ; Ingeborg A. Brouwer [Pays-Bas] ; Claudine Berr [France] ; Catherine Helmer [France] ; Cecilia Samieri [France] ; Markku Laakso [Finlande] ; Michael Y. Tsai [États-Unis] ; Graham G. Giles [Australie] ; Tarja Nurmi [Finlande] ; Lynne Wagenknecht [États-Unis] ; Matthias B. Schulze [Allemagne] ; Rozenn N. Lemaitre [États-Unis] ; Kuo-Liong Chien [Taïwan] ; Sabita S. Soedamah-Muthu [Pays-Bas] ; Johanna M. Geleijnse [Pays-Bas] ; Qi Sun [États-Unis] ; William S. Harris [États-Unis] ; Lars Lind [Suède] ; Johan Rnlöv [Suède] ; Ulf Riserus [Suède] ; Renata Micha [États-Unis] ; Dariush Mozaffarian [États-Unis]Source :
- The lancet. Diabetes & endocrinology [ 2213-8595 ] ; 2017.
Abstract
The metabolic effects of omega-6 polyunsaturated fatty acids (PUFAs) remain contentious, and little evidence is available regarding their potential role in primary prevention of type 2 diabetes. We aimed to assess the associations of linoleic acid and arachidonic acid biomarkers with incident type 2 diabetes.
DOI: 10.1016/S2213-8587(17)30307-8
PubMed: 29032079
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Electronic address: jwu1@georgeinstitute.org.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW</wicri:regionArea></affiliation></author><author><name sortKey="Marklund, Matti" sort="Marklund, Matti" uniqKey="Marklund M" first="Matti" last="Marklund">Matti Marklund</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Imamura, Fumiaki" sort="Imamura, Fumiaki" uniqKey="Imamura F" first="Fumiaki" last="Imamura">Fumiaki Imamura</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Tintle, Nathan" sort="Tintle, Nathan" uniqKey="Tintle N" first="Nathan" last="Tintle">Nathan Tintle</name><affiliation wicri:level="1"><nlm:affiliation>Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mathematics and Statistics, Dordt College, Sioux Center, IA</wicri:regionArea></affiliation></author><author><name sortKey="Ardisson Korat, Andres V" sort="Ardisson Korat, Andres V" uniqKey="Ardisson Korat A" first="Andres V" last="Ardisson Korat">Andres V. 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Chan School of Public Health, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="De Goede, Janette" sort="De Goede, Janette" uniqKey="De Goede J" first="Janette" last="De Goede">Janette De Goede</name><affiliation wicri:level="1"><nlm:affiliation>Division of Human Nutrition, Wageningen University, Wageningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Human Nutrition, Wageningen University, Wageningen</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Xia" sort="Zhou, Xia" uniqKey="Zhou X" first="Xia" last="Zhou">Xia Zhou</name><affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Public Health, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Wei Sin" sort="Yang, Wei Sin" uniqKey="Yang W" first="Wei-Sin" last="Yang">Wei-Sin Yang</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="De Oliveira Otto, Marcia C" sort="De Oliveira Otto, Marcia C" uniqKey="De Oliveira Otto M" first="Marcia C" last="De Oliveira Otto">Marcia C. De Oliveira Otto</name><affiliation wicri:level="1"><nlm:affiliation>Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center, School of Public Health, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center, School of Public Health, Houston, TX</wicri:regionArea></affiliation></author><author><name sortKey="Kroger, Janine" sort="Kroger, Janine" uniqKey="Kroger J" first="Janine" last="Kröger">Janine Kröger</name><affiliation wicri:level="1"><nlm:affiliation>German Institute of Human Nutrition, Potsdam, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Institute of Human Nutrition, Potsdam</wicri:regionArea></affiliation></author><author><name sortKey="Qureshi, Waqas" sort="Qureshi, Waqas" uniqKey="Qureshi W" first="Waqas" last="Qureshi">Waqas Qureshi</name><affiliation wicri:level="1"><nlm:affiliation>Wake Forest University, Winston-Salem, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wake Forest University, Winston-Salem, NC</wicri:regionArea></affiliation></author><author><name sortKey="Virtanen, Jyrki K" sort="Virtanen, Jyrki K" uniqKey="Virtanen J" first="Jyrki K" last="Virtanen">Jyrki K. Virtanen</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Bassett, Julie K" sort="Bassett, Julie K" uniqKey="Bassett J" first="Julie K" last="Bassett">Julie K. Bassett</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Council Victoria, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Council Victoria, Melbourne, VIC</wicri:regionArea></affiliation></author><author><name sortKey="Frazier Wood, Alexis C" sort="Frazier Wood, Alexis C" uniqKey="Frazier Wood A" first="Alexis C" last="Frazier-Wood">Alexis C. 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Murphy</name><affiliation wicri:level="1"><nlm:affiliation>University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia, Vancouver, BC</wicri:regionArea></affiliation></author><author><name sortKey="Rajaobelina, Kalina" sort="Rajaobelina, Kalina" uniqKey="Rajaobelina K" first="Kalina" last="Rajaobelina">Kalina Rajaobelina</name><affiliation wicri:level="1"><nlm:affiliation>University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR 1219, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR 1219, Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Del Gobbo, Liana C" sort="Del Gobbo, Liana C" uniqKey="Del Gobbo L" first="Liana C" last="Del Gobbo">Liana C. Del Gobbo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA</wicri:regionArea></affiliation></author><author><name sortKey="Forouhi, Nita G" sort="Forouhi, Nita G" uniqKey="Forouhi N" first="Nita G" last="Forouhi">Nita G. Forouhi</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Luben, Robert" sort="Luben, Robert" uniqKey="Luben R" first="Robert" last="Luben">Robert Luben</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK; Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK; Department of Mathematics and Statistics, Dordt College, Sioux Center, IA</wicri:regionArea></affiliation></author><author><name sortKey="Wareham, Nick" sort="Wareham, Nick" uniqKey="Wareham N" first="Nick" last="Wareham">Nick Wareham</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Kalsbeek, Anya" sort="Kalsbeek, Anya" uniqKey="Kalsbeek A" first="Anya" last="Kalsbeek">Anya Kalsbeek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA; Department of Biology, Dordt College, Sioux Center, IA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA; Department of Biology, Dordt College, Sioux Center, IA</wicri:regionArea></affiliation></author><author><name sortKey="Veenstra, Jenna" sort="Veenstra, Jenna" uniqKey="Veenstra J" first="Jenna" last="Veenstra">Jenna Veenstra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA; Department of Biology, Dordt College, Sioux Center, IA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA; Department of Biology, Dordt College, Sioux Center, IA</wicri:regionArea></affiliation></author><author><name sortKey="Luo, Juhua" sort="Luo, Juhua" uniqKey="Luo J" first="Juhua" last="Luo">Juhua Luo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Indiana University, Bloomington, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Indiana University, Bloomington, IN</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B" last="Hu">Frank B. Hu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Hung Ju" sort="Lin, Hung Ju" uniqKey="Lin H" first="Hung-Ju" last="Lin">Hung-Ju Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, National Taiwan University Hospital, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S" last="Siscovick">David S. Siscovick</name><affiliation wicri:level="1"><nlm:affiliation>The New York Academy of Medicine, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The New York Academy of Medicine, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation wicri:level="1"><nlm:affiliation>German Institute of Human Nutrition, Potsdam, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Institute of Human Nutrition, Potsdam</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Tzu An" sort="Chen, Tzu An" uniqKey="Chen T" first="Tzu-An" last="Chen">Tzu-An Chen</name><affiliation wicri:level="1"><nlm:affiliation>US Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>US Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, Houston, TX</wicri:regionArea></affiliation></author><author><name sortKey="Steffen, Brian" sort="Steffen, Brian" uniqKey="Steffen B" first="Brian" last="Steffen">Brian Steffen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Steffen, Lyn M" sort="Steffen, Lyn M" uniqKey="Steffen L" first="Lyn M" last="Steffen">Lyn M. Steffen</name><affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Public Health, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Hodge, Allison" sort="Hodge, Allison" uniqKey="Hodge A" first="Allison" last="Hodge">Allison Hodge</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Council Victoria, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Council Victoria, Melbourne, VIC</wicri:regionArea></affiliation></author><author><name sortKey="Eriksdottir, Gudny" sort="Eriksdottir, Gudny" uniqKey="Eriksdottir G" first="Gudny" last="Eriksdottir">Gudny Eriksdottir</name><affiliation wicri:level="1"><nlm:affiliation>Icelandic Heart Institute, Kópavogur, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Institute, Kópavogur</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name><affiliation wicri:level="1"><nlm:affiliation>Icelandic Heart Institute, Kópavogur, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Institute, Kópavogur</wicri:regionArea></affiliation></author><author><name sortKey="Gudnason, Vilmunder" sort="Gudnason, Vilmunder" uniqKey="Gudnason V" first="Vilmunder" last="Gudnason">Vilmunder Gudnason</name><affiliation wicri:level="1"><nlm:affiliation>Icelandic Heart Institute, Kópavogur, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Institute, Kópavogur</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation wicri:level="1"><nlm:affiliation>National Institute on Aging, Bethesda, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute on Aging, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Brouwer, Ingeborg A" sort="Brouwer, Ingeborg A" uniqKey="Brouwer I" first="Ingeborg A" last="Brouwer">Ingeborg A. Brouwer</name><affiliation wicri:level="1"><nlm:affiliation>Health Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Health Sciences, Vrije Universiteit Amsterdam, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1061, Neuropsychiatry: Epidemiological and Clinical Research, and Montpellier University Hospital, Montpellier University, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1061, Neuropsychiatry: Epidemiological and Clinical Research, and Montpellier University Hospital, Montpellier University, Montpellier</wicri:regionArea></affiliation></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><affiliation wicri:level="1"><nlm:affiliation>University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR 1219, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR 1219, Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Samieri, Cecilia" sort="Samieri, Cecilia" uniqKey="Samieri C" first="Cecilia" last="Samieri">Cecilia Samieri</name><affiliation wicri:level="1"><nlm:affiliation>University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR 1219, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR 1219, Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Laakso, Markku" sort="Laakso, Markku" uniqKey="Laakso M" first="Markku" last="Laakso">Markku Laakso</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Tsai, Michael Y" sort="Tsai, Michael Y" uniqKey="Tsai M" first="Michael Y" last="Tsai">Michael Y. Tsai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Council Victoria, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Council Victoria, Melbourne, VIC</wicri:regionArea></affiliation></author><author><name sortKey="Nurmi, Tarja" sort="Nurmi, Tarja" uniqKey="Nurmi T" first="Tarja" last="Nurmi">Tarja Nurmi</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Wagenknecht, Lynne" sort="Wagenknecht, Lynne" uniqKey="Wagenknecht L" first="Lynne" last="Wagenknecht">Lynne Wagenknecht</name><affiliation wicri:level="1"><nlm:affiliation>Wake Forest University, Winston-Salem, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wake Forest University, Winston-Salem, NC</wicri:regionArea></affiliation></author><author><name sortKey="Schulze, Matthias B" sort="Schulze, Matthias B" uniqKey="Schulze M" first="Matthias B" last="Schulze">Matthias B. Schulze</name><affiliation wicri:level="1"><nlm:affiliation>German Institute of Human Nutrition, Potsdam, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Institute of Human Nutrition, Potsdam</wicri:regionArea></affiliation></author><author><name sortKey="Lemaitre, Rozenn N" sort="Lemaitre, Rozenn N" uniqKey="Lemaitre R" first="Rozenn N" last="Lemaitre">Rozenn N. Lemaitre</name><affiliation wicri:level="1"><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Chien, Kuo Liong" sort="Chien, Kuo Liong" uniqKey="Chien K" first="Kuo-Liong" last="Chien">Kuo-Liong Chien</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Soedamah Muthu, Sabita S" sort="Soedamah Muthu, Sabita S" uniqKey="Soedamah Muthu S" first="Sabita S" last="Soedamah-Muthu">Sabita S. Soedamah-Muthu</name><affiliation wicri:level="1"><nlm:affiliation>Division of Human Nutrition, Wageningen University, Wageningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Human Nutrition, Wageningen University, Wageningen</wicri:regionArea></affiliation></author><author><name sortKey="Geleijnse, Johanna M" sort="Geleijnse, Johanna M" uniqKey="Geleijnse J" first="Johanna M" last="Geleijnse">Johanna M. Geleijnse</name><affiliation wicri:level="1"><nlm:affiliation>Division of Human Nutrition, Wageningen University, Wageningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Human Nutrition, Wageningen University, Wageningen</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Qi" sort="Sun, Qi" uniqKey="Sun Q" first="Qi" last="Sun">Qi Sun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Harris, William S" sort="Harris, William S" uniqKey="Harris W" first="William S" last="Harris">William S. Harris</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA; OmegaQuant Analytics, Sioux Falls, SD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA; OmegaQuant Analytics, Sioux Falls, SD</wicri:regionArea></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey=" Rnlov, Johan" sort=" Rnlov, Johan" uniqKey=" Rnlov J" first="Johan" last=" Rnlöv">Johan Rnlöv</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, Care Sciences and Society, Division of Family Medicine, Karolinska Institute, Stockholm, Sweden; School of Health and Social Studies, Dalarna University, Falun, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurobiology, Care Sciences and Society, Division of Family Medicine, Karolinska Institute, Stockholm, Sweden; School of Health and Social Studies, Dalarna University, Falun</wicri:regionArea></affiliation></author><author><name sortKey="Riserus, Ulf" sort="Riserus, Ulf" uniqKey="Riserus U" first="Ulf" last="Riserus">Ulf Riserus</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Micha, Renata" sort="Micha, Renata" uniqKey="Micha R" first="Renata" last="Micha">Renata Micha</name><affiliation wicri:level="1"><nlm:affiliation>Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Mozaffarian, Dariush" sort="Mozaffarian, Dariush" uniqKey="Mozaffarian D" first="Dariush" last="Mozaffarian">Dariush Mozaffarian</name><affiliation wicri:level="1"><nlm:affiliation>Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29032079</idno><idno type="pmid">29032079</idno><idno type="doi">10.1016/S2213-8587(17)30307-8</idno><idno type="wicri:Area/PubMed/Corpus">000262</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000262</idno><idno type="wicri:Area/PubMed/Curation">000260</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000260</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies.</title><author><name sortKey="Wu, Jason H Y" sort="Wu, Jason H Y" uniqKey="Wu J" first="Jason H Y" last="Wu">Jason H Y. Wu</name><affiliation wicri:level="1"><nlm:affiliation>The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia. Electronic address: jwu1@georgeinstitute.org.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW</wicri:regionArea></affiliation></author><author><name sortKey="Marklund, Matti" sort="Marklund, Matti" uniqKey="Marklund M" first="Matti" last="Marklund">Matti Marklund</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Imamura, Fumiaki" sort="Imamura, Fumiaki" uniqKey="Imamura F" first="Fumiaki" last="Imamura">Fumiaki Imamura</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Tintle, Nathan" sort="Tintle, Nathan" uniqKey="Tintle N" first="Nathan" last="Tintle">Nathan Tintle</name><affiliation wicri:level="1"><nlm:affiliation>Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mathematics and Statistics, Dordt College, Sioux Center, IA</wicri:regionArea></affiliation></author><author><name sortKey="Ardisson Korat, Andres V" sort="Ardisson Korat, Andres V" uniqKey="Ardisson Korat A" first="Andres V" last="Ardisson Korat">Andres V. Ardisson Korat</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="De Goede, Janette" sort="De Goede, Janette" uniqKey="De Goede J" first="Janette" last="De Goede">Janette De Goede</name><affiliation wicri:level="1"><nlm:affiliation>Division of Human Nutrition, Wageningen University, Wageningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Human Nutrition, Wageningen University, Wageningen</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Xia" sort="Zhou, Xia" uniqKey="Zhou X" first="Xia" last="Zhou">Xia Zhou</name><affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Public Health, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Wei Sin" sort="Yang, Wei Sin" uniqKey="Yang W" first="Wei-Sin" last="Yang">Wei-Sin Yang</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="De Oliveira Otto, Marcia C" sort="De Oliveira Otto, Marcia C" uniqKey="De Oliveira Otto M" first="Marcia C" last="De Oliveira Otto">Marcia C. De Oliveira Otto</name><affiliation wicri:level="1"><nlm:affiliation>Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center, School of Public Health, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center, School of Public Health, Houston, TX</wicri:regionArea></affiliation></author><author><name sortKey="Kroger, Janine" sort="Kroger, Janine" uniqKey="Kroger J" first="Janine" last="Kröger">Janine Kröger</name><affiliation wicri:level="1"><nlm:affiliation>German Institute of Human Nutrition, Potsdam, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Institute of Human Nutrition, Potsdam</wicri:regionArea></affiliation></author><author><name sortKey="Qureshi, Waqas" sort="Qureshi, Waqas" uniqKey="Qureshi W" first="Waqas" last="Qureshi">Waqas Qureshi</name><affiliation wicri:level="1"><nlm:affiliation>Wake Forest University, Winston-Salem, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wake Forest University, Winston-Salem, NC</wicri:regionArea></affiliation></author><author><name sortKey="Virtanen, Jyrki K" sort="Virtanen, Jyrki K" uniqKey="Virtanen J" first="Jyrki K" last="Virtanen">Jyrki K. Virtanen</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Bassett, Julie K" sort="Bassett, Julie K" uniqKey="Bassett J" first="Julie K" last="Bassett">Julie K. Bassett</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Council Victoria, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Council Victoria, Melbourne, VIC</wicri:regionArea></affiliation></author><author><name sortKey="Frazier Wood, Alexis C" sort="Frazier Wood, Alexis C" uniqKey="Frazier Wood A" first="Alexis C" last="Frazier-Wood">Alexis C. Frazier-Wood</name><affiliation wicri:level="1"><nlm:affiliation>US Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>US Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, Houston, TX</wicri:regionArea></affiliation></author><author><name sortKey="Lankinen, Maria" sort="Lankinen, Maria" uniqKey="Lankinen M" first="Maria" last="Lankinen">Maria Lankinen</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Murphy, Rachel A" sort="Murphy, Rachel A" uniqKey="Murphy R" first="Rachel A" last="Murphy">Rachel A. Murphy</name><affiliation wicri:level="1"><nlm:affiliation>University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia, Vancouver, BC</wicri:regionArea></affiliation></author><author><name sortKey="Rajaobelina, Kalina" sort="Rajaobelina, Kalina" uniqKey="Rajaobelina K" first="Kalina" last="Rajaobelina">Kalina Rajaobelina</name><affiliation wicri:level="1"><nlm:affiliation>University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR 1219, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR 1219, Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Del Gobbo, Liana C" sort="Del Gobbo, Liana C" uniqKey="Del Gobbo L" first="Liana C" last="Del Gobbo">Liana C. Del Gobbo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA</wicri:regionArea></affiliation></author><author><name sortKey="Forouhi, Nita G" sort="Forouhi, Nita G" uniqKey="Forouhi N" first="Nita G" last="Forouhi">Nita G. Forouhi</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Luben, Robert" sort="Luben, Robert" uniqKey="Luben R" first="Robert" last="Luben">Robert Luben</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK; Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK; Department of Mathematics and Statistics, Dordt College, Sioux Center, IA</wicri:regionArea></affiliation></author><author><name sortKey="Wareham, Nick" sort="Wareham, Nick" uniqKey="Wareham N" first="Nick" last="Wareham">Nick Wareham</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Kalsbeek, Anya" sort="Kalsbeek, Anya" uniqKey="Kalsbeek A" first="Anya" last="Kalsbeek">Anya Kalsbeek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA; Department of Biology, Dordt College, Sioux Center, IA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA; Department of Biology, Dordt College, Sioux Center, IA</wicri:regionArea></affiliation></author><author><name sortKey="Veenstra, Jenna" sort="Veenstra, Jenna" uniqKey="Veenstra J" first="Jenna" last="Veenstra">Jenna Veenstra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA; Department of Biology, Dordt College, Sioux Center, IA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA; Department of Biology, Dordt College, Sioux Center, IA</wicri:regionArea></affiliation></author><author><name sortKey="Luo, Juhua" sort="Luo, Juhua" uniqKey="Luo J" first="Juhua" last="Luo">Juhua Luo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Indiana University, Bloomington, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Indiana University, Bloomington, IN</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B" last="Hu">Frank B. Hu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Hung Ju" sort="Lin, Hung Ju" uniqKey="Lin H" first="Hung-Ju" last="Lin">Hung-Ju Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, National Taiwan University Hospital, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S" last="Siscovick">David S. Siscovick</name><affiliation wicri:level="1"><nlm:affiliation>The New York Academy of Medicine, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The New York Academy of Medicine, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation wicri:level="1"><nlm:affiliation>German Institute of Human Nutrition, Potsdam, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Institute of Human Nutrition, Potsdam</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Tzu An" sort="Chen, Tzu An" uniqKey="Chen T" first="Tzu-An" last="Chen">Tzu-An Chen</name><affiliation wicri:level="1"><nlm:affiliation>US Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>US Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, Houston, TX</wicri:regionArea></affiliation></author><author><name sortKey="Steffen, Brian" sort="Steffen, Brian" uniqKey="Steffen B" first="Brian" last="Steffen">Brian Steffen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Steffen, Lyn M" sort="Steffen, Lyn M" uniqKey="Steffen L" first="Lyn M" last="Steffen">Lyn M. Steffen</name><affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Public Health, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Hodge, Allison" sort="Hodge, Allison" uniqKey="Hodge A" first="Allison" last="Hodge">Allison Hodge</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Council Victoria, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Council Victoria, Melbourne, VIC</wicri:regionArea></affiliation></author><author><name sortKey="Eriksdottir, Gudny" sort="Eriksdottir, Gudny" uniqKey="Eriksdottir G" first="Gudny" last="Eriksdottir">Gudny Eriksdottir</name><affiliation wicri:level="1"><nlm:affiliation>Icelandic Heart Institute, Kópavogur, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Institute, Kópavogur</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name><affiliation wicri:level="1"><nlm:affiliation>Icelandic Heart Institute, Kópavogur, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Institute, Kópavogur</wicri:regionArea></affiliation></author><author><name sortKey="Gudnason, Vilmunder" sort="Gudnason, Vilmunder" uniqKey="Gudnason V" first="Vilmunder" last="Gudnason">Vilmunder Gudnason</name><affiliation wicri:level="1"><nlm:affiliation>Icelandic Heart Institute, Kópavogur, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Institute, Kópavogur</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation wicri:level="1"><nlm:affiliation>National Institute on Aging, Bethesda, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute on Aging, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Brouwer, Ingeborg A" sort="Brouwer, Ingeborg A" uniqKey="Brouwer I" first="Ingeborg A" last="Brouwer">Ingeborg A. Brouwer</name><affiliation wicri:level="1"><nlm:affiliation>Health Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Health Sciences, Vrije Universiteit Amsterdam, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1061, Neuropsychiatry: Epidemiological and Clinical Research, and Montpellier University Hospital, Montpellier University, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1061, Neuropsychiatry: Epidemiological and Clinical Research, and Montpellier University Hospital, Montpellier University, Montpellier</wicri:regionArea></affiliation></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><affiliation wicri:level="1"><nlm:affiliation>University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR 1219, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR 1219, Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Samieri, Cecilia" sort="Samieri, Cecilia" uniqKey="Samieri C" first="Cecilia" last="Samieri">Cecilia Samieri</name><affiliation wicri:level="1"><nlm:affiliation>University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR 1219, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR 1219, Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Laakso, Markku" sort="Laakso, Markku" uniqKey="Laakso M" first="Markku" last="Laakso">Markku Laakso</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Tsai, Michael Y" sort="Tsai, Michael Y" uniqKey="Tsai M" first="Michael Y" last="Tsai">Michael Y. Tsai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Council Victoria, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Council Victoria, Melbourne, VIC</wicri:regionArea></affiliation></author><author><name sortKey="Nurmi, Tarja" sort="Nurmi, Tarja" uniqKey="Nurmi T" first="Tarja" last="Nurmi">Tarja Nurmi</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Wagenknecht, Lynne" sort="Wagenknecht, Lynne" uniqKey="Wagenknecht L" first="Lynne" last="Wagenknecht">Lynne Wagenknecht</name><affiliation wicri:level="1"><nlm:affiliation>Wake Forest University, Winston-Salem, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wake Forest University, Winston-Salem, NC</wicri:regionArea></affiliation></author><author><name sortKey="Schulze, Matthias B" sort="Schulze, Matthias B" uniqKey="Schulze M" first="Matthias B" last="Schulze">Matthias B. Schulze</name><affiliation wicri:level="1"><nlm:affiliation>German Institute of Human Nutrition, Potsdam, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Institute of Human Nutrition, Potsdam</wicri:regionArea></affiliation></author><author><name sortKey="Lemaitre, Rozenn N" sort="Lemaitre, Rozenn N" uniqKey="Lemaitre R" first="Rozenn N" last="Lemaitre">Rozenn N. Lemaitre</name><affiliation wicri:level="1"><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Chien, Kuo Liong" sort="Chien, Kuo Liong" uniqKey="Chien K" first="Kuo-Liong" last="Chien">Kuo-Liong Chien</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Soedamah Muthu, Sabita S" sort="Soedamah Muthu, Sabita S" uniqKey="Soedamah Muthu S" first="Sabita S" last="Soedamah-Muthu">Sabita S. Soedamah-Muthu</name><affiliation wicri:level="1"><nlm:affiliation>Division of Human Nutrition, Wageningen University, Wageningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Human Nutrition, Wageningen University, Wageningen</wicri:regionArea></affiliation></author><author><name sortKey="Geleijnse, Johanna M" sort="Geleijnse, Johanna M" uniqKey="Geleijnse J" first="Johanna M" last="Geleijnse">Johanna M. Geleijnse</name><affiliation wicri:level="1"><nlm:affiliation>Division of Human Nutrition, Wageningen University, Wageningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Human Nutrition, Wageningen University, Wageningen</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Qi" sort="Sun, Qi" uniqKey="Sun Q" first="Qi" last="Sun">Qi Sun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Harris, William S" sort="Harris, William S" uniqKey="Harris W" first="William S" last="Harris">William S. Harris</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA; OmegaQuant Analytics, Sioux Falls, SD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA; OmegaQuant Analytics, Sioux Falls, SD</wicri:regionArea></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey=" Rnlov, Johan" sort=" Rnlov, Johan" uniqKey=" Rnlov J" first="Johan" last=" Rnlöv">Johan Rnlöv</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, Care Sciences and Society, Division of Family Medicine, Karolinska Institute, Stockholm, Sweden; School of Health and Social Studies, Dalarna University, Falun, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurobiology, Care Sciences and Society, Division of Family Medicine, Karolinska Institute, Stockholm, Sweden; School of Health and Social Studies, Dalarna University, Falun</wicri:regionArea></affiliation></author><author><name sortKey="Riserus, Ulf" sort="Riserus, Ulf" uniqKey="Riserus U" first="Ulf" last="Riserus">Ulf Riserus</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Micha, Renata" sort="Micha, Renata" uniqKey="Micha R" first="Renata" last="Micha">Renata Micha</name><affiliation wicri:level="1"><nlm:affiliation>Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Mozaffarian, Dariush" sort="Mozaffarian, Dariush" uniqKey="Mozaffarian D" first="Dariush" last="Mozaffarian">Dariush Mozaffarian</name><affiliation wicri:level="1"><nlm:affiliation>Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA</wicri:regionArea></affiliation></author></analytic><series><title level="j">The lancet. Diabetes & endocrinology</title><idno type="eISSN">2213-8595</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The metabolic effects of omega-6 polyunsaturated fatty acids (PUFAs) remain contentious, and little evidence is available regarding their potential role in primary prevention of type 2 diabetes. We aimed to assess the associations of linoleic acid and arachidonic acid biomarkers with incident type 2 diabetes.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">29032079</PMID><DateCreated><Year>2017</Year><Month>10</Month><Day>16</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2213-8595</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Oct</Month><Day>11</Day></PubDate></JournalIssue><Title>The lancet. Diabetes & endocrinology</Title><ISOAbbreviation>Lancet Diabetes Endocrinol</ISOAbbreviation></Journal><ArticleTitle>Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S2213-8587(17)30307-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/S2213-8587(17)30307-8</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The metabolic effects of omega-6 polyunsaturated fatty acids (PUFAs) remain contentious, and little evidence is available regarding their potential role in primary prevention of type 2 diabetes. We aimed to assess the associations of linoleic acid and arachidonic acid biomarkers with incident type 2 diabetes.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We did a pooled analysis of new, harmonised, individual-level analyses for the biomarkers linoleic acid and its metabolite arachidonic acid and incident type 2 diabetes. We analysed data from 20 prospective cohort studies from ten countries (Iceland, the Netherlands, the USA, Taiwan, the UK, Germany, Finland, Australia, Sweden, and France), with biomarkers sampled between 1970 and 2010. Participants included in the analyses were aged 18 years or older and had data available for linoleic acid and arachidonic acid biomarkers at baseline. We excluded participants with type 2 diabetes at baseline. The main outcome was the association between omega-6 PUFA biomarkers and incident type 2 diabetes. We assessed the relative risk of type 2 diabetes prospectively for each cohort and lipid compartment separately using a prespecified analytic plan for exposures, covariates, effect modifiers, and analysis, and the findings were then pooled using inverse-variance weighted meta-analysis.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">Participants were 39 740 adults, aged (range of cohort means) 49-76 years with a BMI (range of cohort means) of 23·3-28·4 kg/m(2), who did not have type 2 diabetes at baseline. During a follow-up of 366 073 person-years, we identified 4347 cases of incident type 2 diabetes. In multivariable-adjusted pooled analyses, higher proportions of linoleic acid biomarkers as percentages of total fatty acid were associated with a lower risk of type 2 diabetes overall (risk ratio [RR] per interquintile range 0·65, 95% CI 0·60-0·72, p<0·0001; I(2)=53·9%, pheterogeneity=0·002). The associations between linoleic acid biomarkers and type 2 diabetes were generally similar in different lipid compartments, including phospholipids, plasma, cholesterol esters, and adipose tissue. Levels of arachidonic acid biomarker were not significantly associated with type 2 diabetes risk overall (RR per interquintile range 0·96, 95% CI 0·88-1·05; p=0·38; I(2)=63·0%, pheterogeneity<0·0001). The associations between linoleic acid and arachidonic acid biomarkers and the risk of type 2 diabetes were not significantly modified by any prespecified potential sources of heterogeneity (ie, age, BMI, sex, race, aspirin use, omega-3 PUFA levels, or variants of the FADS gene; all pheterogeneity≥0·13).</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Findings suggest that linoleic acid has long-term benefits for the prevention of type 2 diabetes and that arachidonic acid is not harmful.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">Funders are shown in the appendix.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Jason H Y</ForeName><Initials>JHY</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia. Electronic address: jwu1@georgeinstitute.org.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marklund</LastName><ForeName>Matti</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Imamura</LastName><ForeName>Fumiaki</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tintle</LastName><ForeName>Nathan</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ardisson Korat</LastName><ForeName>Andres V</ForeName><Initials>AV</Initials><AffiliationInfo><Affiliation>Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Goede</LastName><ForeName>Janette</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Human Nutrition, Wageningen University, Wageningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Xia</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>School of Public Health, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Wei-Sin</ForeName><Initials>WS</Initials><AffiliationInfo><Affiliation>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Oliveira Otto</LastName><ForeName>Marcia C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center, School of Public Health, Houston, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kröger</LastName><ForeName>Janine</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>German Institute of Human Nutrition, Potsdam, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qureshi</LastName><ForeName>Waqas</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Wake Forest University, Winston-Salem, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Virtanen</LastName><ForeName>Jyrki K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bassett</LastName><ForeName>Julie K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Cancer Council Victoria, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frazier-Wood</LastName><ForeName>Alexis C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>US Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, Houston, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lankinen</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Murphy</LastName><ForeName>Rachel A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>University of British Columbia, Vancouver, BC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rajaobelina</LastName><ForeName>Kalina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR 1219, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Del Gobbo</LastName><ForeName>Liana C</ForeName><Initials>LC</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Forouhi</LastName><ForeName>Nita G</ForeName><Initials>NG</Initials><AffiliationInfo><Affiliation>Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luben</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khaw</LastName><ForeName>Kay-Tee</ForeName><Initials>KT</Initials><AffiliationInfo><Affiliation>Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK; Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wareham</LastName><ForeName>Nick</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kalsbeek</LastName><ForeName>Anya</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA; Department of Biology, Dordt College, Sioux Center, IA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Veenstra</LastName><ForeName>Jenna</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA; Department of Biology, Dordt College, Sioux Center, IA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luo</LastName><ForeName>Juhua</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, Indiana University, Bloomington, IN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Frank B</ForeName><Initials>FB</Initials><AffiliationInfo><Affiliation>Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Hung-Ju</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siscovick</LastName><ForeName>David S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>The New York Academy of Medicine, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boeing</LastName><ForeName>Heiner</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>German Institute of Human Nutrition, Potsdam, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Tzu-An</ForeName><Initials>TA</Initials><AffiliationInfo><Affiliation>US Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, Houston, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Steffen</LastName><ForeName>Brian</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Steffen</LastName><ForeName>Lyn M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>School of Public Health, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hodge</LastName><ForeName>Allison</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Cancer Council Victoria, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eriksdottir</LastName><ForeName>Gudny</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Icelandic Heart Institute, Kópavogur, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Albert V</ForeName><Initials>AV</Initials><AffiliationInfo><Affiliation>Icelandic Heart Institute, Kópavogur, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gudnason</LastName><ForeName>Vilmunder</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Icelandic Heart Institute, Kópavogur, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harris</LastName><ForeName>Tamara B</ForeName><Initials>TB</Initials><AffiliationInfo><Affiliation>National Institute on Aging, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brouwer</LastName><ForeName>Ingeborg A</ForeName><Initials>IA</Initials><AffiliationInfo><Affiliation>Health Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berr</LastName><ForeName>Claudine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>INSERM U1061, Neuropsychiatry: Epidemiological and Clinical Research, and Montpellier University Hospital, Montpellier University, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Helmer</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR 1219, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Samieri</LastName><ForeName>Cecilia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR 1219, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laakso</LastName><ForeName>Markku</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsai</LastName><ForeName>Michael Y</ForeName><Initials>MY</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giles</LastName><ForeName>Graham G</ForeName><Initials>GG</Initials><AffiliationInfo><Affiliation>Cancer Council Victoria, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nurmi</LastName><ForeName>Tarja</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wagenknecht</LastName><ForeName>Lynne</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Wake Forest University, Winston-Salem, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schulze</LastName><ForeName>Matthias B</ForeName><Initials>MB</Initials><AffiliationInfo><Affiliation>German Institute of Human Nutrition, Potsdam, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lemaitre</LastName><ForeName>Rozenn N</ForeName><Initials>RN</Initials><AffiliationInfo><Affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chien</LastName><ForeName>Kuo-Liong</ForeName><Initials>KL</Initials><AffiliationInfo><Affiliation>Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soedamah-Muthu</LastName><ForeName>Sabita S</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Division of Human Nutrition, Wageningen University, Wageningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Geleijnse</LastName><ForeName>Johanna M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Division of Human Nutrition, Wageningen University, Wageningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Qi</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harris</LastName><ForeName>William S</ForeName><Initials>WS</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA; OmegaQuant Analytics, Sioux Falls, SD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lind</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ärnlöv</LastName><ForeName>Johan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, Care Sciences and Society, Division of Family Medicine, Karolinska Institute, Stockholm, Sweden; School of Health and Social Studies, Dalarna University, Falun, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riserus</LastName><ForeName>Ulf</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Micha</LastName><ForeName>Renata</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mozaffarian</LastName><ForeName>Dariush</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCE)</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>10</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lancet Diabetes Endocrinol</MedlineTA><NlmUniqueID>101618821</NlmUniqueID><ISSNLinking>2213-8587</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>06</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>08</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>08</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>10</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>10</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29032079</ArticleId><ArticleId IdType="pii">S2213-8587(17)30307-8</ArticleId><ArticleId IdType="doi">10.1016/S2213-8587(17)30307-8</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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