Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial.
Identifieur interne : 000014 ( PubMed/Curation ); précédent : 000013; suivant : 000015Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial.
Auteurs : Sonia S. Anand [Canada] ; Jackie Bosch [Canada] ; John W. Eikelboom [Canada] ; Stuart J. Connolly [Canada] ; Rafael Diaz [Argentine] ; Peter Widimsky [République tchèque] ; Victor Aboyans [France] ; Marco Alings [Pays-Bas] ; Ajay K. Kakkar [Royaume-Uni] ; Katalin Keltai [Hongrie] ; Aldo P. Maggioni [Italie] ; Basil S. Lewis [Israël] ; Stefan Störk [Allemagne] ; Jun Zhu [République populaire de Chine] ; Patricio Lopez-Jaramillo [Colombie] ; Martin O'Donnell [Irlande (pays)] ; Patrick J. Commerford [Afrique du Sud] ; Dragos Vinereanu [Roumanie] ; Nana Pogosova [Russie] ; Lars Ryden [Suède] ; Keith A A. Fox [Royaume-Uni] ; Deepak L. Bhatt [États-Unis] ; Frank Misselwitz [Allemagne] ; John D. Varigos [Australie] ; Thomas Vanassche [Belgique] ; Alvaro A. Avezum [Brésil] ; Edmond Chen [États-Unis] ; Kelley Branch [États-Unis] ; Darryl P. Leong [Canada] ; Shrikant I. Bangdiwala [Canada] ; Robert G. Hart [Canada] ; Salim Yusuf [Canada]Source :
- Lancet (London, England) [ 1474-547X ] ; 2017.
Abstract
Patients with peripheral artery disease have an increased risk of cardiovascular morbidity and mortality. Antiplatelet agents are widely used to reduce these complications.
DOI: 10.1016/S0140-6736(17)32409-1
PubMed: 29132880
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Connolly</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON</wicri:regionArea></affiliation></author><author><name sortKey="Diaz, Rafael" sort="Diaz, Rafael" uniqKey="Diaz R" first="Rafael" last="Diaz">Rafael Diaz</name><affiliation wicri:level="1"><nlm:affiliation>Estudios Clínicos Latino America and Instituto Cardiovascular de Rosario, Rosario, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Estudios Clínicos Latino America and Instituto Cardiovascular de Rosario, Rosario</wicri:regionArea></affiliation></author><author><name sortKey="Widimsky, Peter" sort="Widimsky, Peter" uniqKey="Widimsky P" first="Peter" last="Widimsky">Peter Widimsky</name><affiliation wicri:level="1"><nlm:affiliation>Cardiocenter, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University Prague, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Cardiocenter, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University Prague, Prague</wicri:regionArea></affiliation></author><author><name sortKey="Aboyans, Victor" sort="Aboyans, Victor" uniqKey="Aboyans V" first="Victor" last="Aboyans">Victor Aboyans</name><affiliation wicri:level="1"><nlm:affiliation>Dupuytren University Hospital, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Dupuytren University Hospital, Limoges</wicri:regionArea></affiliation></author><author><name sortKey="Alings, Marco" sort="Alings, Marco" uniqKey="Alings M" first="Marco" last="Alings">Marco Alings</name><affiliation wicri:level="1"><nlm:affiliation>Amphia Ziekenhuis and Werkgroep Cardiologische centra Nederland, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Amphia Ziekenhuis and Werkgroep Cardiologische centra Nederland, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Kakkar, Ajay K" sort="Kakkar, Ajay K" uniqKey="Kakkar A" first="Ajay K" last="Kakkar">Ajay K. Kakkar</name><affiliation wicri:level="1"><nlm:affiliation>Thrombosis Research Institute and University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Thrombosis Research Institute and University College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Keltai, Katalin" sort="Keltai, Katalin" uniqKey="Keltai K" first="Katalin" last="Keltai">Katalin Keltai</name><affiliation wicri:level="1"><nlm:affiliation>3rd Department of Internal Medicine. Semmelweis University, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>3rd Department of Internal Medicine. Semmelweis University, Budapest</wicri:regionArea></affiliation></author><author><name sortKey="Maggioni, Aldo P" sort="Maggioni, Aldo P" uniqKey="Maggioni A" first="Aldo P" last="Maggioni">Aldo P. Maggioni</name><affiliation wicri:level="1"><nlm:affiliation>ANMCO Research Center, Florence, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>ANMCO Research Center, Florence</wicri:regionArea></affiliation></author><author><name sortKey="Lewis, Basil S" sort="Lewis, Basil S" uniqKey="Lewis B" first="Basil S" last="Lewis">Basil S. Lewis</name><affiliation wicri:level="1"><nlm:affiliation>Lady Davis Carmel Medical Centre and the Ruth and Bruce Rappaport School of Medicine, Technion-IIT, Haifa, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Lady Davis Carmel Medical Centre and the Ruth and Bruce Rappaport School of Medicine, Technion-IIT, Haifa</wicri:regionArea></affiliation></author><author><name sortKey="Stork, Stefan" sort="Stork, Stefan" uniqKey="Stork S" first="Stefan" last="Störk">Stefan Störk</name><affiliation wicri:level="1"><nlm:affiliation>Comprehensive Heart Failure Center, University Hospital at University of Würzburg, Würzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Comprehensive Heart Failure Center, University Hospital at University of Würzburg, Würzburg</wicri:regionArea></affiliation></author><author><name sortKey="Zhu, Jun" sort="Zhu, Jun" uniqKey="Zhu J" first="Jun" last="Zhu">Jun Zhu</name><affiliation wicri:level="1"><nlm:affiliation>FuWai Hospital, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>FuWai Hospital, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Lopez Jaramillo, Patricio" sort="Lopez Jaramillo, Patricio" uniqKey="Lopez Jaramillo P" first="Patricio" last="Lopez-Jaramillo">Patricio Lopez-Jaramillo</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute, FOSCAL-Bucaramanga, Bucaramanga, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Research Institute, FOSCAL-Bucaramanga, Bucaramanga</wicri:regionArea></affiliation></author><author><name sortKey="O Donnell, Martin" sort="O Donnell, Martin" uniqKey="O Donnell M" first="Martin" last="O'Donnell">Martin O'Donnell</name><affiliation wicri:level="1"><nlm:affiliation>National University of Ireland, Galway, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>National University of Ireland, Galway</wicri:regionArea></affiliation></author><author><name sortKey="Commerford, Patrick J" sort="Commerford, Patrick J" uniqKey="Commerford P" first="Patrick J" last="Commerford">Patrick J. Commerford</name><affiliation wicri:level="1"><nlm:affiliation>University of Cape Town, Cape Town, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>University of Cape Town, Cape Town</wicri:regionArea></affiliation></author><author><name sortKey="Vinereanu, Dragos" sort="Vinereanu, Dragos" uniqKey="Vinereanu D" first="Dragos" last="Vinereanu">Dragos Vinereanu</name><affiliation wicri:level="1"><nlm:affiliation>University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest</wicri:regionArea></affiliation></author><author><name sortKey="Pogosova, Nana" sort="Pogosova, Nana" uniqKey="Pogosova N" first="Nana" last="Pogosova">Nana Pogosova</name><affiliation wicri:level="1"><nlm:affiliation>National Research Centre for Preventative Medicine, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>National Research Centre for Preventative Medicine, Moscow</wicri:regionArea></affiliation></author><author><name sortKey="Ryden, Lars" sort="Ryden, Lars" uniqKey="Ryden L" first="Lars" last="Ryden">Lars Ryden</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine K2, Karolinska Institute, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicine K2, Karolinska Institute, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Fox, Keith A A" sort="Fox, Keith A A" uniqKey="Fox K" first="Keith A A" last="Fox">Keith A A. Fox</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cardiovascular Science, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Bhatt, Deepak L" sort="Bhatt, Deepak L" uniqKey="Bhatt D" first="Deepak L" last="Bhatt">Deepak L. Bhatt</name><affiliation wicri:level="1"><nlm:affiliation>Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Misselwitz, Frank" sort="Misselwitz, Frank" uniqKey="Misselwitz F" first="Frank" last="Misselwitz">Frank Misselwitz</name><affiliation wicri:level="1"><nlm:affiliation>Bayer AG, Leverkusen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bayer AG, Leverkusen</wicri:regionArea></affiliation></author><author><name sortKey="Varigos, John D" sort="Varigos, John D" uniqKey="Varigos J" first="John D" last="Varigos">John D. Varigos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC</wicri:regionArea></affiliation></author><author><name sortKey="Vanassche, Thomas" sort="Vanassche, Thomas" uniqKey="Vanassche T" first="Thomas" last="Vanassche">Thomas Vanassche</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Cardiovascular Sciences, University of Leuven, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Avezum, Alvaro A" sort="Avezum, Alvaro A" uniqKey="Avezum A" first="Alvaro A" last="Avezum">Alvaro A. Avezum</name><affiliation wicri:level="1"><nlm:affiliation>Dante Pazzanese Institute of Cardiology & University Santo Amaro, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Dante Pazzanese Institute of Cardiology & University Santo Amaro, São Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Edmond" sort="Chen, Edmond" uniqKey="Chen E" first="Edmond" last="Chen">Edmond Chen</name><affiliation wicri:level="1"><nlm:affiliation>Bayer AG, Whippany, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bayer AG, Whippany, NJ</wicri:regionArea></affiliation></author><author><name sortKey="Branch, Kelley" sort="Branch, Kelley" uniqKey="Branch K" first="Kelley" last="Branch">Kelley Branch</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine (Cardiology), University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Cardiology), University of Washington, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Leong, Darryl P" sort="Leong, Darryl P" uniqKey="Leong D" first="Darryl P" last="Leong">Darryl P. Leong</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON</wicri:regionArea></affiliation></author><author><name sortKey="Bangdiwala, Shrikant I" sort="Bangdiwala, Shrikant I" uniqKey="Bangdiwala S" first="Shrikant I" last="Bangdiwala">Shrikant I. Bangdiwala</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON</wicri:regionArea></affiliation></author><author><name sortKey="Hart, Robert G" sort="Hart, Robert G" uniqKey="Hart R" first="Robert G" last="Hart">Robert G. Hart</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON</wicri:regionArea></affiliation></author><author><name sortKey="Yusuf, Salim" sort="Yusuf, Salim" uniqKey="Yusuf S" first="Salim" last="Yusuf">Salim Yusuf</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29132880</idno><idno type="pmid">29132880</idno><idno type="doi">10.1016/S0140-6736(17)32409-1</idno><idno type="wicri:Area/PubMed/Corpus">000014</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000014</idno><idno type="wicri:Area/PubMed/Curation">000014</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000014</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial.</title><author><name sortKey="Anand, Sonia S" sort="Anand, Sonia S" uniqKey="Anand S" first="Sonia S" last="Anand">Sonia S. Anand</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada. Electronic address: anands@mcmaster.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON</wicri:regionArea></affiliation></author><author><name sortKey="Bosch, Jackie" sort="Bosch, Jackie" uniqKey="Bosch J" first="Jackie" last="Bosch">Jackie Bosch</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; School of Rehabilitation Sciences, McMaster University, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; School of Rehabilitation Sciences, McMaster University, Hamilton, ON</wicri:regionArea></affiliation></author><author><name sortKey="Eikelboom, John W" sort="Eikelboom, John W" uniqKey="Eikelboom J" first="John W" last="Eikelboom">John W. Eikelboom</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON</wicri:regionArea></affiliation></author><author><name sortKey="Connolly, Stuart J" sort="Connolly, Stuart J" uniqKey="Connolly S" first="Stuart J" last="Connolly">Stuart J. Connolly</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON</wicri:regionArea></affiliation></author><author><name sortKey="Diaz, Rafael" sort="Diaz, Rafael" uniqKey="Diaz R" first="Rafael" last="Diaz">Rafael Diaz</name><affiliation wicri:level="1"><nlm:affiliation>Estudios Clínicos Latino America and Instituto Cardiovascular de Rosario, Rosario, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Estudios Clínicos Latino America and Instituto Cardiovascular de Rosario, Rosario</wicri:regionArea></affiliation></author><author><name sortKey="Widimsky, Peter" sort="Widimsky, Peter" uniqKey="Widimsky P" first="Peter" last="Widimsky">Peter Widimsky</name><affiliation wicri:level="1"><nlm:affiliation>Cardiocenter, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University Prague, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Cardiocenter, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University Prague, Prague</wicri:regionArea></affiliation></author><author><name sortKey="Aboyans, Victor" sort="Aboyans, Victor" uniqKey="Aboyans V" first="Victor" last="Aboyans">Victor Aboyans</name><affiliation wicri:level="1"><nlm:affiliation>Dupuytren University Hospital, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Dupuytren University Hospital, Limoges</wicri:regionArea></affiliation></author><author><name sortKey="Alings, Marco" sort="Alings, Marco" uniqKey="Alings M" first="Marco" last="Alings">Marco Alings</name><affiliation wicri:level="1"><nlm:affiliation>Amphia Ziekenhuis and Werkgroep Cardiologische centra Nederland, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Amphia Ziekenhuis and Werkgroep Cardiologische centra Nederland, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Kakkar, Ajay K" sort="Kakkar, Ajay K" uniqKey="Kakkar A" first="Ajay K" last="Kakkar">Ajay K. Kakkar</name><affiliation wicri:level="1"><nlm:affiliation>Thrombosis Research Institute and University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Thrombosis Research Institute and University College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Keltai, Katalin" sort="Keltai, Katalin" uniqKey="Keltai K" first="Katalin" last="Keltai">Katalin Keltai</name><affiliation wicri:level="1"><nlm:affiliation>3rd Department of Internal Medicine. Semmelweis University, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>3rd Department of Internal Medicine. Semmelweis University, Budapest</wicri:regionArea></affiliation></author><author><name sortKey="Maggioni, Aldo P" sort="Maggioni, Aldo P" uniqKey="Maggioni A" first="Aldo P" last="Maggioni">Aldo P. Maggioni</name><affiliation wicri:level="1"><nlm:affiliation>ANMCO Research Center, Florence, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>ANMCO Research Center, Florence</wicri:regionArea></affiliation></author><author><name sortKey="Lewis, Basil S" sort="Lewis, Basil S" uniqKey="Lewis B" first="Basil S" last="Lewis">Basil S. Lewis</name><affiliation wicri:level="1"><nlm:affiliation>Lady Davis Carmel Medical Centre and the Ruth and Bruce Rappaport School of Medicine, Technion-IIT, Haifa, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Lady Davis Carmel Medical Centre and the Ruth and Bruce Rappaport School of Medicine, Technion-IIT, Haifa</wicri:regionArea></affiliation></author><author><name sortKey="Stork, Stefan" sort="Stork, Stefan" uniqKey="Stork S" first="Stefan" last="Störk">Stefan Störk</name><affiliation wicri:level="1"><nlm:affiliation>Comprehensive Heart Failure Center, University Hospital at University of Würzburg, Würzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Comprehensive Heart Failure Center, University Hospital at University of Würzburg, Würzburg</wicri:regionArea></affiliation></author><author><name sortKey="Zhu, Jun" sort="Zhu, Jun" uniqKey="Zhu J" first="Jun" last="Zhu">Jun Zhu</name><affiliation wicri:level="1"><nlm:affiliation>FuWai Hospital, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>FuWai Hospital, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Lopez Jaramillo, Patricio" sort="Lopez Jaramillo, Patricio" uniqKey="Lopez Jaramillo P" first="Patricio" last="Lopez-Jaramillo">Patricio Lopez-Jaramillo</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute, FOSCAL-Bucaramanga, Bucaramanga, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Research Institute, FOSCAL-Bucaramanga, Bucaramanga</wicri:regionArea></affiliation></author><author><name sortKey="O Donnell, Martin" sort="O Donnell, Martin" uniqKey="O Donnell M" first="Martin" last="O'Donnell">Martin O'Donnell</name><affiliation wicri:level="1"><nlm:affiliation>National University of Ireland, Galway, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>National University of Ireland, Galway</wicri:regionArea></affiliation></author><author><name sortKey="Commerford, Patrick J" sort="Commerford, Patrick J" uniqKey="Commerford P" first="Patrick J" last="Commerford">Patrick J. Commerford</name><affiliation wicri:level="1"><nlm:affiliation>University of Cape Town, Cape Town, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>University of Cape Town, Cape Town</wicri:regionArea></affiliation></author><author><name sortKey="Vinereanu, Dragos" sort="Vinereanu, Dragos" uniqKey="Vinereanu D" first="Dragos" last="Vinereanu">Dragos Vinereanu</name><affiliation wicri:level="1"><nlm:affiliation>University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest</wicri:regionArea></affiliation></author><author><name sortKey="Pogosova, Nana" sort="Pogosova, Nana" uniqKey="Pogosova N" first="Nana" last="Pogosova">Nana Pogosova</name><affiliation wicri:level="1"><nlm:affiliation>National Research Centre for Preventative Medicine, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>National Research Centre for Preventative Medicine, Moscow</wicri:regionArea></affiliation></author><author><name sortKey="Ryden, Lars" sort="Ryden, Lars" uniqKey="Ryden L" first="Lars" last="Ryden">Lars Ryden</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine K2, Karolinska Institute, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicine K2, Karolinska Institute, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Fox, Keith A A" sort="Fox, Keith A A" uniqKey="Fox K" first="Keith A A" last="Fox">Keith A A. Fox</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cardiovascular Science, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Bhatt, Deepak L" sort="Bhatt, Deepak L" uniqKey="Bhatt D" first="Deepak L" last="Bhatt">Deepak L. Bhatt</name><affiliation wicri:level="1"><nlm:affiliation>Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Misselwitz, Frank" sort="Misselwitz, Frank" uniqKey="Misselwitz F" first="Frank" last="Misselwitz">Frank Misselwitz</name><affiliation wicri:level="1"><nlm:affiliation>Bayer AG, Leverkusen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bayer AG, Leverkusen</wicri:regionArea></affiliation></author><author><name sortKey="Varigos, John D" sort="Varigos, John D" uniqKey="Varigos J" first="John D" last="Varigos">John D. Varigos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC</wicri:regionArea></affiliation></author><author><name sortKey="Vanassche, Thomas" sort="Vanassche, Thomas" uniqKey="Vanassche T" first="Thomas" last="Vanassche">Thomas Vanassche</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Cardiovascular Sciences, University of Leuven, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Avezum, Alvaro A" sort="Avezum, Alvaro A" uniqKey="Avezum A" first="Alvaro A" last="Avezum">Alvaro A. Avezum</name><affiliation wicri:level="1"><nlm:affiliation>Dante Pazzanese Institute of Cardiology & University Santo Amaro, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Dante Pazzanese Institute of Cardiology & University Santo Amaro, São Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Edmond" sort="Chen, Edmond" uniqKey="Chen E" first="Edmond" last="Chen">Edmond Chen</name><affiliation wicri:level="1"><nlm:affiliation>Bayer AG, Whippany, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bayer AG, Whippany, NJ</wicri:regionArea></affiliation></author><author><name sortKey="Branch, Kelley" sort="Branch, Kelley" uniqKey="Branch K" first="Kelley" last="Branch">Kelley Branch</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine (Cardiology), University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Cardiology), University of Washington, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Leong, Darryl P" sort="Leong, Darryl P" uniqKey="Leong D" first="Darryl P" last="Leong">Darryl P. Leong</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON</wicri:regionArea></affiliation></author><author><name sortKey="Bangdiwala, Shrikant I" sort="Bangdiwala, Shrikant I" uniqKey="Bangdiwala S" first="Shrikant I" last="Bangdiwala">Shrikant I. Bangdiwala</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON</wicri:regionArea></affiliation></author><author><name sortKey="Hart, Robert G" sort="Hart, Robert G" uniqKey="Hart R" first="Robert G" last="Hart">Robert G. Hart</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON</wicri:regionArea></affiliation></author><author><name sortKey="Yusuf, Salim" sort="Yusuf, Salim" uniqKey="Yusuf S" first="Salim" last="Yusuf">Salim Yusuf</name><affiliation wicri:level="1"><nlm:affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON</wicri:regionArea></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with peripheral artery disease have an increased risk of cardiovascular morbidity and mortality. Antiplatelet agents are widely used to reduce these complications.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">29132880</PMID><DateCreated><Year>2017</Year><Month>11</Month><Day>14</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-547X</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Nov</Month><Day>10</Day></PubDate></JournalIssue><Title>Lancet (London, England)</Title><ISOAbbreviation>Lancet</ISOAbbreviation></Journal><ArticleTitle>Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S0140-6736(17)32409-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/S0140-6736(17)32409-1</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Patients with peripheral artery disease have an increased risk of cardiovascular morbidity and mortality. Antiplatelet agents are widely used to reduce these complications.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">This was a multicentre, double-blind, randomised placebo-controlled trial for which patients were recruited at 602 hospitals, clinics, or community practices from 33 countries across six continents. Eligible patients had a history of peripheral artery disease of the lower extremities (previous peripheral bypass surgery or angioplasty, limb or foot amputation, intermittent claudication with objective evidence of peripheral artery disease), of the carotid arteries (previous carotid artery revascularisation or asymptomatic carotid artery stenosis of at least 50%), or coronary artery disease with an ankle-brachial index of less than 0·90. After a 30-day run-in period, patients were randomly assigned (1:1:1) to receive oral rivaroxaban (2·5 mg twice a day) plus aspirin (100 mg once a day), rivaroxaban twice a day (5 mg with aspirin placebo once a day), or to aspirin once a day (100 mg and rivaroxaban placebo twice a day). Randomisation was computer generated. Each treatment group was double dummy, and the patient, investigators, and central study staff were masked to treatment allocation. The primary outcome was cardiovascular death, myocardial infarction or stroke; the primary peripheral artery disease outcome was major adverse limb events including major amputation. This trial is registered with ClinicalTrials.gov, number NCT01776424, and is closed to new participants.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">Between March 12, 2013, and May 10, 2016, we enrolled 7470 patients with peripheral artery disease from 558 centres. The combination of rivaroxaban plus aspirin compared with aspirin alone reduced the composite endpoint of cardiovascular death, myocardial infarction, or stroke (126 [5%] of 2492 vs 174 [7%] of 2504; hazard ratio [HR] 0·72, 95% CI 0·57-0·90, p=0·0047), and major adverse limb events including major amputation (32 [1%] vs 60 [2%]; HR 0·54 95% CI 0·35-0·82, p=0·0037). Rivaroxaban 5 mg twice a day compared with aspirin alone did not significantly reduce the composite endpoint (149 [6%] of 2474 vs 174 [7%] of 2504; HR 0·86, 95% CI 0·69-1·08, p=0·19), but reduced major adverse limb events including major amputation (40 [2%] vs 60 [2%]; HR 0·67, 95% CI 0·45-1·00, p=0·05). The median duration of treatment was 21 months. The use of the rivaroxaban plus aspirin combination increased major bleeding compared with the aspirin alone group (77 [3%] of 2492 vs 48 [2%] of 2504; HR 1·61, 95% CI 1·12-2·31, p=0·0089), which was mainly gastrointestinal. Similarly, major bleeding occurred in 79 (3%) of 2474 patients with rivaroxaban 5 mg, and in 48 (2%) of 2504 in the aspirin alone group (HR 1·68, 95% CI 1·17-2·40; p=0·0043).</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Low-dose rivaroxaban taken twice a day plus aspirin once a day reduced major adverse cardiovascular and limb events when compared with aspirin alone. Although major bleeding was increased, fatal or critical organ bleeding was not. This combination therapy represents an important advance in the management of patients with peripheral artery disease. Rivaroxaban alone did not significantly reduce major adverse cardiovascular events compared with asprin alone, but reduced major adverse limb events and increased major bleeding.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">Bayer AG.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Anand</LastName><ForeName>Sonia S</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada. Electronic address: anands@mcmaster.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bosch</LastName><ForeName>Jackie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; School of Rehabilitation Sciences, McMaster University, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eikelboom</LastName><ForeName>John W</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Connolly</LastName><ForeName>Stuart J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Diaz</LastName><ForeName>Rafael</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Estudios Clínicos Latino America and Instituto Cardiovascular de Rosario, Rosario, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Widimsky</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Cardiocenter, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University Prague, Prague, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aboyans</LastName><ForeName>Victor</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Dupuytren University Hospital, Limoges, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alings</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Amphia Ziekenhuis and Werkgroep Cardiologische centra Nederland, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kakkar</LastName><ForeName>Ajay K</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>Thrombosis Research Institute and University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Keltai</LastName><ForeName>Katalin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>3rd Department of Internal Medicine. Semmelweis University, Budapest, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maggioni</LastName><ForeName>Aldo P</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>ANMCO Research Center, Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lewis</LastName><ForeName>Basil S</ForeName><Initials>BS</Initials><AffiliationInfo><Affiliation>Lady Davis Carmel Medical Centre and the Ruth and Bruce Rappaport School of Medicine, Technion-IIT, Haifa, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Störk</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Comprehensive Heart Failure Center, University Hospital at University of Würzburg, Würzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Jun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>FuWai Hospital, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lopez-Jaramillo</LastName><ForeName>Patricio</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Research Institute, FOSCAL-Bucaramanga, Bucaramanga, Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Donnell</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>National University of Ireland, Galway, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Commerford</LastName><ForeName>Patrick J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>University of Cape Town, Cape Town, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vinereanu</LastName><ForeName>Dragos</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pogosova</LastName><ForeName>Nana</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>National Research Centre for Preventative Medicine, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ryden</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Medicine K2, Karolinska Institute, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fox</LastName><ForeName>Keith A A</ForeName><Initials>KAA</Initials><AffiliationInfo><Affiliation>Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bhatt</LastName><ForeName>Deepak L</ForeName><Initials>DL</Initials><AffiliationInfo><Affiliation>Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Misselwitz</LastName><ForeName>Frank</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Bayer AG, Leverkusen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Varigos</LastName><ForeName>John D</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vanassche</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Avezum</LastName><ForeName>Alvaro A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Dante Pazzanese Institute of Cardiology & University Santo Amaro, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Edmond</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Bayer AG, Whippany, NJ, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Branch</LastName><ForeName>Kelley</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Medicine (Cardiology), University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leong</LastName><ForeName>Darryl P</ForeName><Initials>DP</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bangdiwala</LastName><ForeName>Shrikant I</ForeName><Initials>SI</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hart</LastName><ForeName>Robert G</ForeName><Initials>RG</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yusuf</LastName><ForeName>Salim</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>COMPASS Investigators</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>11</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lancet</MedlineTA><NlmUniqueID>2985213R</NlmUniqueID><ISSNLinking>0140-6736</ISSNLinking></MedlineJournalInfo><InvestigatorList><Investigator ValidYN="Y"><LastName>Sala</LastName><ForeName>Jorgelina</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cartasegna</LastName><ForeName>Luis</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vico</LastName><ForeName>Marisa</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hominal</LastName><ForeName>Miguel Angel</ForeName><Initials>MA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hasbani</LastName><ForeName>Eduardo</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Caccavo</LastName><ForeName>Alberto</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zaidman</LastName><ForeName>Cesar</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vogel</LastName><ForeName>Daniel</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hrabar</LastName><ForeName>Adrian</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Schygiel</LastName><ForeName>Pablo Omar</ForeName><Initials>PO</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cuneo</LastName><ForeName>Carlos</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Luquez</LastName><ForeName>Hugo</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mackinnon</LastName><ForeName>Ignacio J</ForeName><Initials>IJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ahuad 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ValidYN="Y"><LastName>Garrido</LastName><ForeName>Marcelo</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ingaramo</LastName><ForeName>Adrian</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bordonava</LastName><ForeName>Anselmo Paulino</ForeName><Initials>AP</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pelagagge</LastName><ForeName>Maria Jose</ForeName><Initials>MJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Novaretto</LastName><ForeName>Leonardo</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Albisu DI Gennero</LastName><ForeName>Juan Pablo</ForeName><Initials>JP</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ibanez Saggia</LastName><ForeName>Luz Maria</ForeName><Initials>LM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Alvarez</LastName><ForeName>Moira</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vita</LastName><ForeName>Nestor Alejandro</ForeName><Initials>NA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Macin</LastName><ForeName>Stella Maris</ForeName><Initials>SM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dran</LastName><ForeName>Ricardo Dario</ForeName><Initials>RD</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cardona</LastName><ForeName>Marcelo</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Guzman</LastName><ForeName>Luis</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sarjanovich</LastName><ForeName>Rodolfo Juan</ForeName><Initials>RJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cuadrado</LastName><ForeName>Jesus</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nani</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Litvak Bruno</LastName><ForeName>Marcos Raul</ForeName><Initials>MR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chacon</LastName><ForeName>Carolina</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Maffei</LastName><ForeName>Laura Elena</ForeName><Initials>LE</Initials></Investigator><Investigator ValidYN="Y"><LastName>Grinfeld</LastName><ForeName>Diego</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vensentini</LastName><ForeName>Natalia</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Majul</LastName><ForeName>Claudio Rodolfo</ForeName><Initials>CR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Luciardi</LastName><ForeName>Hector Lucas</ForeName><Initials>HL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gonzalez Colaso</LastName><ForeName>Patricia Del Carmen</ForeName><Initials>PDC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ferre Pacora</LastName><ForeName>Fredy Antoni</ForeName><Initials>FA</Initials></Investigator><Investigator ValidYN="Y"><LastName>VAN DEN Heuvel</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Verhamme</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ector</LastName><ForeName>Bavo</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Debonnaire</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>VAN DE Borne</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Leroy</LastName><ForeName>Jean</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Schroe</LastName><ForeName>Herman</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vranckx</LastName><ForeName>Pascal</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Elegeert</LastName><ForeName>Ivan</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hoffer</LastName><ForeName>Etienne</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dujardin</LastName><ForeName>Karl</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Indio DO Brasil</LastName><ForeName>Clarisse</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Precoma</LastName><ForeName>Dalton</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Abrantes</LastName><ForeName>Jose Antonio</ForeName><Initials>JA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Manenti</LastName><ForeName>Euler</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Reis</LastName><ForeName>Gilmar</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Saraiva</LastName><ForeName>Jose</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Maia</LastName><ForeName>Lilia</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hernandes</LastName><ForeName>Mauro</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rossi</LastName><ForeName>Paulo</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rossi Dos Santos</LastName><ForeName>Fabio</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zimmermann</LastName><ForeName>Sergio Luiz</ForeName><Initials>SL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rech</LastName><ForeName>Rafael</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Abib</LastName><ForeName>Eduardo</ForeName><Initials>E</Initials><Suffix>Jr</Suffix></Investigator><Investigator ValidYN="Y"><LastName>Leaes</LastName><ForeName>Paulo</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Botelho</LastName><ForeName>Roberto</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dutra</LastName><ForeName>Oscar</ForeName><Initials>O</Initials></Investigator><Investigator ValidYN="Y"><LastName>Souza</LastName><ForeName>Weimar</ForeName><Initials>W</Initials></Investigator><Investigator ValidYN="Y"><LastName>Braile</LastName><ForeName>Maria</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Izukawa</LastName><ForeName>Nilo</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nicolau</LastName><ForeName>Jose Carlos</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tanajura</LastName><ForeName>Luiz Fernando</ForeName><Initials>LF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Serrano Junior</LastName><ForeName>Carlos Vicente</ForeName><Initials>CV</Initials></Investigator><Investigator ValidYN="Y"><LastName>Minelli</LastName><ForeName>Cesar</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nasi</LastName><ForeName>Luiz Antonio</ForeName><Initials>LA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Oliveira</LastName><ForeName>Livia</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>DE Carvalho Cantarelli</LastName><ForeName>Marcelo Jose</ForeName><Initials>MJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tytus</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pandey</LastName><ForeName>Shekhar</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lonn</LastName><ForeName>Eva</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cha</LastName><ForeName>James</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vizel</LastName><ForeName>Saul</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Babapulle</LastName><ForeName>Mohan</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lamy</LastName><ForeName>Andre</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Saunders</LastName><ForeName>Kevin</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Berlingieri</LastName><ForeName>Joseph</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kiaii</LastName><ForeName>Bob</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bhargava</LastName><ForeName>Rakesh</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mehta</LastName><ForeName>Pravinsagar</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hill</LastName><ForeName>Laurie</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fell</LastName><ForeName>David</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lam</LastName><ForeName>Andy</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Al-Qoofi</LastName><ForeName>Faisal</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Brown</LastName><ForeName>Craig</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Petrella</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ricci</LastName><ForeName>Joseph A</ForeName><Initials>JA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Glanz</LastName><ForeName>Anthony</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Noiseux</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bainey</LastName><ForeName>Kevin</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Merali</LastName><ForeName>Fatima</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Heffernan</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Della Siega</LastName><ForeName>Anthony</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dagenais</LastName><ForeName>Gilles R</ForeName><Initials>GR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dagenais</LastName><ForeName>Francois</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Brulotte</LastName><ForeName>Steeve</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nguyen</LastName><ForeName>Michel</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hartleib</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Guzman</LastName><ForeName>Randolph</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bourgeois</LastName><ForeName>Ronald</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rupka</LastName><ForeName>Dennis</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Khaykin</LastName><ForeName>Yaariv</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gosselin</LastName><ForeName>Gilbert</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Huynh</LastName><ForeName>Thao</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pilon</LastName><ForeName>Claude</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Campeau</LastName><ForeName>Jean</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pichette</LastName><ForeName>Francis</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Diaz</LastName><ForeName>Ariel</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Johnston</LastName><ForeName>James</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shukle</LastName><ForeName>Pravin</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hirsch</LastName><ForeName>Gregory</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rheault</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Czarnecki</LastName><ForeName>Wlodzimierz</ForeName><Initials>W</Initials></Investigator><Investigator ValidYN="Y"><LastName>Roy</LastName><ForeName>Annie</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nawaz</LastName><ForeName>Shah</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fremes</LastName><ForeName>Stephen</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shukla</LastName><ForeName>Dinkar</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jano</LastName><ForeName>Gabriel</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cobos</LastName><ForeName>Jorge Leonardo</ForeName><Initials>JL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Corbalan</LastName><ForeName>Ramon</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Medina</LastName><ForeName>Marcelo</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nahuelpan</LastName><ForeName>Leonardo</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Raffo</LastName><ForeName>Carlos</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Perez</LastName><ForeName>Luis</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Potthoff</LastName><ForeName>Sergio</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Stockins</LastName><ForeName>Benjamin</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sepulveda</LastName><ForeName>Pablo</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pincetti</LastName><ForeName>Christian</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vejar</LastName><ForeName>Margarita</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tian</LastName><ForeName>Hongyan</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wu</LastName><ForeName>Xuesi</ForeName><Initials>X</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ke</LastName><ForeName>Yuannan</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jia</LastName><ForeName>Kaiying</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Yin</LastName><ForeName>Pengfei</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wang</LastName><ForeName>Zhaohui</ForeName><Initials>Z</Initials></Investigator><Investigator ValidYN="Y"><LastName>Yu</LastName><ForeName>Litian</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wu</LastName><ForeName>Shulin</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wu</LastName><ForeName>Zongqui</ForeName><Initials>Z</Initials></Investigator><Investigator ValidYN="Y"><LastName>Liu</LastName><ForeName>Shao Wen</ForeName><Initials>SW</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bai</LastName><ForeName>Xiao Juan</ForeName><Initials>XJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zheng</LastName><ForeName>Yang</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Yang</LastName><ForeName>Ping</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Yang</LastName><ForeName>Yun Mei</ForeName><Initials>YM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zhang</LastName><ForeName>Jiwei</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ge</LastName><ForeName>Junbo</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chen</LastName><ForeName>Xiao Ping</ForeName><Initials>XP</Initials></Investigator><Investigator ValidYN="Y"><LastName>Li</LastName><ForeName>Junxia</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hu</LastName><ForeName>Tao Hong</ForeName><Initials>TH</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zhang</LastName><ForeName>Ruiyan</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zheng</LastName><ForeName>Zhe</ForeName><Initials>Z</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chen</LastName><ForeName>Xin</ForeName><Initials>X</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tao</LastName><ForeName>Liang</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Li</LastName><ForeName>Jianping</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Huang</LastName><ForeName>Weijian</ForeName><Initials>W</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fu</LastName><ForeName>Guosheng</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Li</LastName><ForeName>Chunjian</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dong</LastName><ForeName>Yugang</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wang</LastName><ForeName>Chunsheng</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zhou</LastName><ForeName>Xinmin</ForeName><Initials>X</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kong</LastName><ForeName>Y E</ForeName><Initials>YE</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sotomayor</LastName><ForeName>Aristides</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Accini Mendoza</LastName><ForeName>Jose Luis</ForeName><Initials>JL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Castillo</LastName><ForeName>Henry</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Urina</LastName><ForeName>Miguel</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Aroca</LastName><ForeName>Gustavo</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Perez</LastName><ForeName>Maritza</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Molina DE Salazar</LastName><ForeName>Dora Ines</ForeName><Initials>DI</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sanchez Vallejo</LastName><ForeName>Gregorio</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Manzur J</LastName><ForeName>Fernando</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Garcia</LastName><ForeName>Henry</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Garcia</LastName><ForeName>Luis Hernando</ForeName><Initials>LH</Initials></Investigator><Investigator ValidYN="Y"><LastName>Arcos</LastName><ForeName>Edgar</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gomez</LastName><ForeName>Juan</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cuervo Millan</LastName><ForeName>Francisco</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Trujillo Dada</LastName><ForeName>Fredy Alberto</ForeName><Initials>FA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vesga</LastName><ForeName>Boris</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Moreno Silgado</LastName><ForeName>Gustavo Adolfo</ForeName><Initials>GA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zidkova</LastName><ForeName>Eva</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lubanda</LastName><ForeName>Jean-Claude</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kaletova</LastName><ForeName>Marketa</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kryza</LastName><ForeName>Radim</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marcinek</LastName><ForeName>Gabriel</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Richter</LastName><ForeName>Marek</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Spinar</LastName><ForeName>Jindrich</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Matuska</LastName><ForeName>Jiri</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tesak</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Motovska</LastName><ForeName>Zuzana</ForeName><Initials>Z</Initials></Investigator><Investigator ValidYN="Y"><LastName>Branny</LastName><ForeName>Marian</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Maly</LastName><ForeName>Jiri</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Maly</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wiendl</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Foltynova Caisova</LastName><ForeName>Lenka</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Slaby</LastName><ForeName>Josef</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vojtisek</LastName><ForeName>Petr</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pirk</LastName><ForeName>Jan</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Spinarova</LastName><ForeName>Lenka</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Benesova</LastName><ForeName>Miroslava</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Canadyova</LastName><ForeName>Julia</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Homza</LastName><ForeName>Miroslav</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Florian</LastName><ForeName>Jindrich</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Polasek</LastName><ForeName>Rostislav</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Coufal</LastName><ForeName>Zdenek</ForeName><Initials>Z</Initials></Investigator><Investigator ValidYN="Y"><LastName>Skalnikova</LastName><ForeName>Vladimira</ForeName><Initials>V</Initials></Investigator><Investigator ValidYN="Y"><LastName>Brat</LastName><ForeName>Radim</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Brtko</LastName><ForeName>Miroslav</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jansky</LastName><ForeName>Petr</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lindner</LastName><ForeName>Jaroslav</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marcian</LastName><ForeName>Pavel</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Straka</LastName><ForeName>Zbynek</ForeName><Initials>Z</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tretina</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Duarte</LastName><ForeName>Yan Carlos</ForeName><Initials>YC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pow Chon Long</LastName><ForeName>Freddy</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sanchez</LastName><ForeName>Mayra</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lopez</LastName><ForeName>Jose</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Perugachi</LastName><ForeName>Carmita</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marmol</LastName><ForeName>Ricardo</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Trujillo</LastName><ForeName>Freddy</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Teran</LastName><ForeName>Pablo</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tuomilehto</LastName><ForeName>Jaakko</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tuomilehto</LastName><ForeName>Henri</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tuominen</LastName><ForeName>Marja-Leena</ForeName><Initials>ML</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tuomilehto</LastName><ForeName>Henri</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kantola</LastName><ForeName>Ilkka</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Steg</LastName><ForeName>Gabriel</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Aboyans</LastName><ForeName>Victor</ForeName><Initials>V</Initials></Investigator><Investigator ValidYN="Y"><LastName>Leclercq</LastName><ForeName>Florence</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ferrari</LastName><ForeName>Emile</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Boccara</LastName><ForeName>Franck</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Messas</LastName><ForeName>Emmanuel</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mismetti</LastName><ForeName>Patrick</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sevestre</LastName><ForeName>Marie Antoinette</ForeName><Initials>MA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cayla</LastName><ForeName>Guillaume</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Motreff</LastName><ForeName>Pascal</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Stoerk</LastName><ForeName>Stefan</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Duengen</LastName><ForeName>Hans-Dirk</ForeName><Initials>HD</Initials></Investigator><Investigator ValidYN="Y"><LastName>Stellbrink</LastName><ForeName>Christoph</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Guerocak</LastName><ForeName>Osman</ForeName><Initials>O</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kadel</LastName><ForeName>Christoph</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Braun-Dullaeus</LastName><ForeName>Ruediger</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jeserich</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Opitz</LastName><ForeName>Christian</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Voehringer</LastName><ForeName>Hans-Friedrich</ForeName><Initials>HF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Appel</LastName><ForeName>Karl-Friedrich</ForeName><Initials>KF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Winkelmann</LastName><ForeName>Bernhard</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dorsel</LastName><ForeName>Thomas</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nikol</LastName><ForeName>Sigrid</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Darius</LastName><ForeName>Harald</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ranft</LastName><ForeName>Jurgen</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Schellong</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jungmair</LastName><ForeName>Wolfgang</ForeName><Initials>W</Initials></Investigator><Investigator ValidYN="Y"><LastName>Davierwala</LastName><ForeName>Piroze</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vorpahl</LastName><ForeName>Marc</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bajnok</LastName><ForeName>Laszlo</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Laszlo</LastName><ForeName>Zoltan</ForeName><Initials>Z</Initials></Investigator><Investigator ValidYN="Y"><LastName>Noori</LastName><ForeName>Ebrahim</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Veress</LastName><ForeName>Gabor</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vertes</LastName><ForeName>Andras</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zsary</LastName><ForeName>Andras</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kis</LastName><ForeName>Erno</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Koranyi</LastName><ForeName>Laszlo</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bakai</LastName><ForeName>Judit</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Boda</LastName><ForeName>Zoltan</ForeName><Initials>Z</Initials></Investigator><Investigator ValidYN="Y"><LastName>Poor</LastName><ForeName>Ferenc</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jarai</LastName><ForeName>Zoltan</ForeName><Initials>Z</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kemeny</LastName><ForeName>Vendel</ForeName><Initials>V</Initials></Investigator><Investigator ValidYN="Y"><LastName>Barton</LastName><ForeName>John</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>McAdam</LastName><ForeName>Brendan</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Murphy</LastName><ForeName>Andrew</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Crean</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mahon</LastName><ForeName>Niall</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Curtin</LastName><ForeName>Ronan</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Macneill</LastName><ForeName>Briain</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dinneen</LastName><ForeName>Sean</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Halabi</LastName><ForeName>Majdi</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zimlichman</LastName><ForeName>Reuven</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zeltser</LastName><ForeName>David</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Turgeman</LastName><ForeName>Yoav</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Klainman</LastName><ForeName>Eliezer</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lewis</LastName><ForeName>Basil</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Katz</LastName><ForeName>Amos</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Atar</LastName><ForeName>Shaul</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zimlichman</LastName><ForeName>Reuven</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nikolsky</LastName><ForeName>Eugenia</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bosi</LastName><ForeName>Stefano</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Naldi</LastName><ForeName>Monica</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Faggiano</LastName><ForeName>Pompilio</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Robba</LastName><ForeName>Debora</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mos</LastName><ForeName>Lucio</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sinagra</LastName><ForeName>Gianfranco</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cosmi</LastName><ForeName>Franco</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Oltrona Visconti</LastName><ForeName>Luigi</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Carmine</LastName><ForeName>DE Matteis</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>DI Pasquale</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>DI Biase</LastName><ForeName>Matteo</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mandorla</LastName><ForeName>Sara</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bernardinangeli</LastName><ForeName>Marino</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Piccinni</LastName><ForeName>Giovanni Carlo</ForeName><Initials>GC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gulizia</LastName><ForeName>Michele Massimo</ForeName><Initials>MM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Galvani</LastName><ForeName>Marcello</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Venturi</LastName><ForeName>Flavio</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Morocutti</LastName><ForeName>Giorgio</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Baldin</LastName><ForeName>Maria Grazia</ForeName><Initials>MG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Olivieri</LastName><ForeName>Carlo</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Perna</LastName><ForeName>Gian Piero</ForeName><Initials>GP</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cirrincione</LastName><ForeName>Vincenzo</ForeName><Initials>V</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kanno</LastName><ForeName>Takayasu</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Daida</LastName><ForeName>Hiroyuki</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ozaki</LastName><ForeName>Yukio</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Miyamoto</LastName><ForeName>Naomasa</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Higashiue</LastName><ForeName>Shinichi</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Domae</LastName><ForeName>Hiroshi</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hosokawa</LastName><ForeName>Shinobu</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kobayashi</LastName><ForeName>Hiroo</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kuramochi</LastName><ForeName>Takehiko</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fujii</LastName><ForeName>Kenshi</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mizutomi</LastName><ForeName>Kazuaki</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Saku</LastName><ForeName>Keijiro</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kimura</LastName><ForeName>Kazuo</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Higuchi</LastName><ForeName>Yoshiharu</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Abe</LastName><ForeName>Mitsunori</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Okuda</LastName><ForeName>Haruhito</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Noda</LastName><ForeName>Toshiyuki</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mita</LastName><ForeName>Teruaki</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hirayama</LastName><ForeName>Atsushi</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Onaka</LastName><ForeName>Haruhiko</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Inoko</LastName><ForeName>Moriaki</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hirokami</LastName><ForeName>Mitsugu</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Okubo</LastName><ForeName>Munenori</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Akatsuka</LastName><ForeName>Yutaka</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Imamaki</LastName><ForeName>Mizuho</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kamiya</LastName><ForeName>Haruo</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Manita</LastName><ForeName>Mamoru</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Himi</LastName><ForeName>Toshiharu</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ueno</LastName><ForeName>Hideki</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hisamatsu</LastName><ForeName>Yuji</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ako</LastName><ForeName>Junya</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nishino</LastName><ForeName>Yasuhiro</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kawakami</LastName><ForeName>Hideo</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Yamada</LastName><ForeName>Yutaka</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Koretsune</LastName><ForeName>Yukihiro</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Yamada</LastName><ForeName>Takahisa</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Yoshida</LastName><ForeName>Tetsuro</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shimomura</LastName><ForeName>Hideki</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kinoshita</LastName><ForeName>Noriyuki</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Takahashi</LastName><ForeName>Akihiko</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Yusoff</LastName><ForeName>Khalid</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wan Ahmad</LastName><ForeName>Wan Azman</ForeName><Initials>WA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Abu Hassan</LastName><ForeName>Muhammad Radzi</ForeName><Initials>MR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kasim</LastName><ForeName>Sazzli</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Abdul Rahim</LastName><ForeName>Aizai Azan</ForeName><Initials>AA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mohd Zamrin</LastName><ForeName>Dimon</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Machida</LastName><ForeName>Masaharu</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Higashino</LastName><ForeName>Yorihiko</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Utsu</LastName><ForeName>Noriaki</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nakano</LastName><ForeName>Akihiko</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nakamura</LastName><ForeName>Shigeru</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hashimoto</LastName><ForeName>Tetsuo</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ando</LastName><ForeName>Kenji</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sakamoto</LastName><ForeName>Tomohiro</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Prins</LastName><ForeName>F J</ForeName><Initials>FJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lok</LastName><ForeName>Dirk</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Milhous</LastName><ForeName>Johannes Gert-Jan</ForeName><Initials>JG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Viergever</LastName><ForeName>Eric</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Willems</LastName><ForeName>Frank</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Swart</LastName><ForeName>Henk</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Alings</LastName><ForeName>Marco</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Breedveld</LastName><ForeName>Rob</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>DE Vries</LastName><ForeName>Kees-Jan</ForeName><Initials>KJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>VAN DER Borgh</LastName><ForeName>Roger</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Oei</LastName><ForeName>Fanny</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zoet-Nugteren</LastName><ForeName>Stieneke</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kragten</LastName><ForeName>Hans</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Herrman</LastName><ForeName>Jean Paul</ForeName><Initials>JP</Initials></Investigator><Investigator ValidYN="Y"><LastName>VAN Bergen</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gosselink</LastName><ForeName>Marcel</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hoekstra</LastName><ForeName>Eduard</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zegers</LastName><ForeName>Erwin</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ronner</LastName><ForeName>Eelko</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>DEN Hartog</LastName><ForeName>Frank</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bartels</LastName><ForeName>Gerard</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nierop</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>VAN DER Zwaan</LastName><ForeName>Coen</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>VAN Eck</LastName><ForeName>Jacob</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>VAN Gorselen</LastName><ForeName>Edwin</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Groenemeijer</LastName><ForeName>Bjorn</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hoogslag</LastName><ForeName>Pieter</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>DE Groot</LastName><ForeName>Marc Robert</ForeName><Initials>MR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Loyola</LastName><ForeName>Aldrin</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sulit</LastName><ForeName>Dennis Jose</ForeName><Initials>DJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rey</LastName><ForeName>Nannette</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Abola</LastName><ForeName>Maria Teresa</ForeName><Initials>MT</Initials></Investigator><Investigator ValidYN="Y"><LastName>Morales</LastName><ForeName>Dante</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Palomares</LastName><ForeName>Ellen</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Abat</LastName><ForeName>Marc Evans</ForeName><Initials>ME</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rogelio</LastName><ForeName>Gregorio</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chua</LastName><ForeName>Philip</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Del Pilar</LastName><ForeName>Jose Carlo</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Alcaraz</LastName><ForeName>John Dennis</ForeName><Initials>JD</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ebo</LastName><ForeName>Geraldine</ForeName><Initials>G</Initials></Investigator><Investigator 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