Biomarkers of oxidative stress study V: ozone exposure of rats and its effect on lipids, proteins, and DNA in plasma and urine.
Identifieur interne : 003B35 ( PubMed/Corpus ); précédent : 003B34; suivant : 003B36Biomarkers of oxidative stress study V: ozone exposure of rats and its effect on lipids, proteins, and DNA in plasma and urine.
Auteurs : Maria B. Kadiiska ; Samar Basu ; Nathan Brot ; Christopher Cooper ; A. Saari Csallany ; Michael J. Davies ; Magdalene M. George ; Dennis M. Murray ; L. Jackson Roberts ; Mark K. Shigenaga ; Rajindar S. Sohal ; Roland Stocker ; David H. Van Thiel ; Ingrid Wiswedel ; Gary E. Hatch ; Ronald P. MasonSource :
- Free radical biology & medicine [ 1873-4596 ] ; 2013.
English descriptors
- KwdEn :
- Animals, Biomarkers (analysis), DNA (analysis), DNA (blood), DNA (urine), Dinoprost (analogs & derivatives), Dinoprost (analysis), Lipid Peroxides (analysis), Lipids (analysis), Lipids (blood), Lipids (urine), Male, Malondialdehyde (analysis), Methionine (metabolism), Oxidation-Reduction, Oxidative Stress, Ozone (toxicity), Proteins (analysis), Rats, Rats, Inbred F344.
- MESH :
- chemical , analogs & derivatives : Dinoprost.
- chemical , analysis : Biomarkers, DNA, Dinoprost, Lipid Peroxides, Lipids, Malondialdehyde, Proteins.
- chemical , blood : DNA, Lipids.
- chemical , metabolism : Methionine.
- chemical , toxicity : Ozone.
- chemical , urine : DNA, Lipids.
- Animals, Male, Oxidation-Reduction, Oxidative Stress, Rats, Rats, Inbred F344.
Abstract
Ozone exposure effect on free radical-catalyzed oxidation products of lipids, proteins, and DNA in the plasma and urine of rats was studied as a continuation of the international Biomarker of Oxidative Stress Study (BOSS) sponsored by NIEHS/NIH. The goal was to identify a biomarker for ozone-induced oxidative stress and to assess whether inconsistent results often reported in the literature might be due to the limitations of the available methods for measuring the various types of oxidative products. The time- and dose-dependent effects of ozone exposure on rat plasma lipid hydroperoxides, malondialdehyde, F2-isoprostanes, protein carbonyls, methionine oxidation, and tyrosine- and phenylalanine oxidation products, as well as urinary malondialdehyde and F2-isoprostanes were investigated with various techniques. The criterion used to recognize a marker in the model of ozone exposure was that a significant effect could be identified and measured in a biological fluid seen at both doses at more than one time point. No statistically significant differences between the experimental and the control groups at either ozone dose and time point studied could be identified in this study. Tissue samples were not included. Despite all the work accomplished in the BOSS study of ozone, no available product of oxidation in biological fluid has yet met the required criteria of being a biomarker. The current negative findings as a consequence of ozone exposure are of great importance, because they document that in complex systems, as the present in vivo experiment, the assays used may not provide meaningful data of ozone oxidation, especially in human studies.
DOI: 10.1016/j.freeradbiomed.2013.04.023
PubMed: 23608465
Links to Exploration step
pubmed:23608465Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Biomarkers of oxidative stress study V: ozone exposure of rats and its effect on lipids, proteins, and DNA in plasma and urine.</title><author><name sortKey="Kadiiska, Maria B" sort="Kadiiska, Maria B" uniqKey="Kadiiska M" first="Maria B" last="Kadiiska">Maria B. Kadiiska</name><affiliation><nlm:affiliation>National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA. Electronic address: Kadiiska@niehs.nih.gov.</nlm:affiliation></affiliation></author><author><name sortKey="Basu, Samar" sort="Basu, Samar" uniqKey="Basu S" first="Samar" last="Basu">Samar Basu</name><affiliation><nlm:affiliation>Faculty of Medicine, Uppsala University, Uppsala, Sweden; Biochemistry, Molecular Biology and Nutrition Department, University of Auvergne, Clermont-Ferrand, France.</nlm:affiliation></affiliation></author><author><name sortKey="Brot, Nathan" sort="Brot, Nathan" uniqKey="Brot N" first="Nathan" last="Brot">Nathan Brot</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cooper, Christopher" sort="Cooper, Christopher" uniqKey="Cooper C" first="Christopher" last="Cooper">Christopher Cooper</name><affiliation><nlm:affiliation>School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Saari Csallany, A" sort="Saari Csallany, A" uniqKey="Saari Csallany A" first="A" last="Saari Csallany">A. Saari Csallany</name><affiliation><nlm:affiliation>Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Davies, Michael J" sort="Davies, Michael J" uniqKey="Davies M" first="Michael J" last="Davies">Michael J. Davies</name><affiliation><nlm:affiliation>The Heart Research Institute, University of Sydney, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="George, Magdalene M" sort="George, Magdalene M" uniqKey="George M" first="Magdalene M" last="George">Magdalene M. George</name><affiliation><nlm:affiliation>Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Murray, Dennis M" sort="Murray, Dennis M" uniqKey="Murray D" first="Dennis M" last="Murray">Dennis M. Murray</name><affiliation><nlm:affiliation>Northwest Life Science Specialties, LLC., Vancouver, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jackson Roberts, L" sort="Jackson Roberts, L" uniqKey="Jackson Roberts L" first="L" last="Jackson Roberts">L. Jackson Roberts</name><affiliation><nlm:affiliation>Department of Pharmacology and Medicine, Vanderbilt University, Nashville, TN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Shigenaga, Mark K" sort="Shigenaga, Mark K" uniqKey="Shigenaga M" first="Mark K" last="Shigenaga">Mark K. Shigenaga</name><affiliation><nlm:affiliation>Children's Hospital Oakland Research Institute, Oakland, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sohal, Rajindar S" sort="Sohal, Rajindar S" uniqKey="Sohal R" first="Rajindar S" last="Sohal">Rajindar S. Sohal</name><affiliation><nlm:affiliation>University of Southern California, Los Angeles, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Stocker, Roland" sort="Stocker, Roland" uniqKey="Stocker R" first="Roland" last="Stocker">Roland Stocker</name><affiliation><nlm:affiliation>Victor Chang Cardiac Research Institute, Darlinghurst, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Van Thiel, David H" sort="Van Thiel, David H" uniqKey="Van Thiel D" first="David H" last="Van Thiel">David H. Van Thiel</name><affiliation><nlm:affiliation>Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wiswedel, Ingrid" sort="Wiswedel, Ingrid" uniqKey="Wiswedel I" first="Ingrid" last="Wiswedel">Ingrid Wiswedel</name><affiliation><nlm:affiliation>Otto-von-Guericke-University, Magdeburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hatch, Gary E" sort="Hatch, Gary E" uniqKey="Hatch G" first="Gary E" last="Hatch">Gary E. Hatch</name><affiliation><nlm:affiliation>United States Environmental Protection Agency, Research Triangle Park, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mason, Ronald P" sort="Mason, Ronald P" uniqKey="Mason R" first="Ronald P" last="Mason">Ronald P. Mason</name><affiliation><nlm:affiliation>National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23608465</idno><idno type="pmid">23608465</idno><idno type="doi">10.1016/j.freeradbiomed.2013.04.023</idno><idno type="wicri:Area/PubMed/Corpus">003B35</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003B35</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Biomarkers of oxidative stress study V: ozone exposure of rats and its effect on lipids, proteins, and DNA in plasma and urine.</title><author><name sortKey="Kadiiska, Maria B" sort="Kadiiska, Maria B" uniqKey="Kadiiska M" first="Maria B" last="Kadiiska">Maria B. Kadiiska</name><affiliation><nlm:affiliation>National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA. Electronic address: Kadiiska@niehs.nih.gov.</nlm:affiliation></affiliation></author><author><name sortKey="Basu, Samar" sort="Basu, Samar" uniqKey="Basu S" first="Samar" last="Basu">Samar Basu</name><affiliation><nlm:affiliation>Faculty of Medicine, Uppsala University, Uppsala, Sweden; Biochemistry, Molecular Biology and Nutrition Department, University of Auvergne, Clermont-Ferrand, France.</nlm:affiliation></affiliation></author><author><name sortKey="Brot, Nathan" sort="Brot, Nathan" uniqKey="Brot N" first="Nathan" last="Brot">Nathan Brot</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cooper, Christopher" sort="Cooper, Christopher" uniqKey="Cooper C" first="Christopher" last="Cooper">Christopher Cooper</name><affiliation><nlm:affiliation>School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Saari Csallany, A" sort="Saari Csallany, A" uniqKey="Saari Csallany A" first="A" last="Saari Csallany">A. Saari Csallany</name><affiliation><nlm:affiliation>Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Davies, Michael J" sort="Davies, Michael J" uniqKey="Davies M" first="Michael J" last="Davies">Michael J. Davies</name><affiliation><nlm:affiliation>The Heart Research Institute, University of Sydney, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="George, Magdalene M" sort="George, Magdalene M" uniqKey="George M" first="Magdalene M" last="George">Magdalene M. George</name><affiliation><nlm:affiliation>Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Murray, Dennis M" sort="Murray, Dennis M" uniqKey="Murray D" first="Dennis M" last="Murray">Dennis M. Murray</name><affiliation><nlm:affiliation>Northwest Life Science Specialties, LLC., Vancouver, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jackson Roberts, L" sort="Jackson Roberts, L" uniqKey="Jackson Roberts L" first="L" last="Jackson Roberts">L. Jackson Roberts</name><affiliation><nlm:affiliation>Department of Pharmacology and Medicine, Vanderbilt University, Nashville, TN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Shigenaga, Mark K" sort="Shigenaga, Mark K" uniqKey="Shigenaga M" first="Mark K" last="Shigenaga">Mark K. Shigenaga</name><affiliation><nlm:affiliation>Children's Hospital Oakland Research Institute, Oakland, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sohal, Rajindar S" sort="Sohal, Rajindar S" uniqKey="Sohal R" first="Rajindar S" last="Sohal">Rajindar S. Sohal</name><affiliation><nlm:affiliation>University of Southern California, Los Angeles, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Stocker, Roland" sort="Stocker, Roland" uniqKey="Stocker R" first="Roland" last="Stocker">Roland Stocker</name><affiliation><nlm:affiliation>Victor Chang Cardiac Research Institute, Darlinghurst, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Van Thiel, David H" sort="Van Thiel, David H" uniqKey="Van Thiel D" first="David H" last="Van Thiel">David H. Van Thiel</name><affiliation><nlm:affiliation>Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wiswedel, Ingrid" sort="Wiswedel, Ingrid" uniqKey="Wiswedel I" first="Ingrid" last="Wiswedel">Ingrid Wiswedel</name><affiliation><nlm:affiliation>Otto-von-Guericke-University, Magdeburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hatch, Gary E" sort="Hatch, Gary E" uniqKey="Hatch G" first="Gary E" last="Hatch">Gary E. Hatch</name><affiliation><nlm:affiliation>United States Environmental Protection Agency, Research Triangle Park, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mason, Ronald P" sort="Mason, Ronald P" uniqKey="Mason R" first="Ronald P" last="Mason">Ronald P. Mason</name><affiliation><nlm:affiliation>National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Free radical biology & medicine</title><idno type="eISSN">1873-4596</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biomarkers (analysis)</term><term>DNA (analysis)</term><term>DNA (blood)</term><term>DNA (urine)</term><term>Dinoprost (analogs & derivatives)</term><term>Dinoprost (analysis)</term><term>Lipid Peroxides (analysis)</term><term>Lipids (analysis)</term><term>Lipids (blood)</term><term>Lipids (urine)</term><term>Male</term><term>Malondialdehyde (analysis)</term><term>Methionine (metabolism)</term><term>Oxidation-Reduction</term><term>Oxidative Stress</term><term>Ozone (toxicity)</term><term>Proteins (analysis)</term><term>Rats</term><term>Rats, Inbred F344</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Dinoprost</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers</term><term>DNA</term><term>Dinoprost</term><term>Lipid Peroxides</term><term>Lipids</term><term>Malondialdehyde</term><term>Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>DNA</term><term>Lipids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Methionine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Ozone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>DNA</term><term>Lipids</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Oxidation-Reduction</term><term>Oxidative Stress</term><term>Rats</term><term>Rats, Inbred F344</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ozone exposure effect on free radical-catalyzed oxidation products of lipids, proteins, and DNA in the plasma and urine of rats was studied as a continuation of the international Biomarker of Oxidative Stress Study (BOSS) sponsored by NIEHS/NIH. The goal was to identify a biomarker for ozone-induced oxidative stress and to assess whether inconsistent results often reported in the literature might be due to the limitations of the available methods for measuring the various types of oxidative products. The time- and dose-dependent effects of ozone exposure on rat plasma lipid hydroperoxides, malondialdehyde, F2-isoprostanes, protein carbonyls, methionine oxidation, and tyrosine- and phenylalanine oxidation products, as well as urinary malondialdehyde and F2-isoprostanes were investigated with various techniques. The criterion used to recognize a marker in the model of ozone exposure was that a significant effect could be identified and measured in a biological fluid seen at both doses at more than one time point. No statistically significant differences between the experimental and the control groups at either ozone dose and time point studied could be identified in this study. Tissue samples were not included. Despite all the work accomplished in the BOSS study of ozone, no available product of oxidation in biological fluid has yet met the required criteria of being a biomarker. The current negative findings as a consequence of ozone exposure are of great importance, because they document that in complex systems, as the present in vivo experiment, the assays used may not provide meaningful data of ozone oxidation, especially in human studies.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23608465</PMID><DateCreated><Year>2014</Year><Month>10</Month><Day>13</Day></DateCreated><DateCompleted><Year>2015</Year><Month>08</Month><Day>21</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-4596</ISSN><JournalIssue CitedMedium="Internet"><Volume>61</Volume><PubDate><Year>2013</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Free radical biology & medicine</Title><ISOAbbreviation>Free Radic. Biol. Med.</ISOAbbreviation></Journal><ArticleTitle>Biomarkers of oxidative stress study V: ozone exposure of rats and its effect on lipids, proteins, and DNA in plasma and urine.</ArticleTitle><Pagination><MedlinePgn>408-15</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.freeradbiomed.2013.04.023</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0891-5849(13)00163-9</ELocationID><Abstract><AbstractText>Ozone exposure effect on free radical-catalyzed oxidation products of lipids, proteins, and DNA in the plasma and urine of rats was studied as a continuation of the international Biomarker of Oxidative Stress Study (BOSS) sponsored by NIEHS/NIH. The goal was to identify a biomarker for ozone-induced oxidative stress and to assess whether inconsistent results often reported in the literature might be due to the limitations of the available methods for measuring the various types of oxidative products. The time- and dose-dependent effects of ozone exposure on rat plasma lipid hydroperoxides, malondialdehyde, F2-isoprostanes, protein carbonyls, methionine oxidation, and tyrosine- and phenylalanine oxidation products, as well as urinary malondialdehyde and F2-isoprostanes were investigated with various techniques. The criterion used to recognize a marker in the model of ozone exposure was that a significant effect could be identified and measured in a biological fluid seen at both doses at more than one time point. No statistically significant differences between the experimental and the control groups at either ozone dose and time point studied could be identified in this study. Tissue samples were not included. Despite all the work accomplished in the BOSS study of ozone, no available product of oxidation in biological fluid has yet met the required criteria of being a biomarker. The current negative findings as a consequence of ozone exposure are of great importance, because they document that in complex systems, as the present in vivo experiment, the assays used may not provide meaningful data of ozone oxidation, especially in human studies.</AbstractText><CopyrightInformation>Published by Elsevier Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kadiiska</LastName><ForeName>Maria B</ForeName><Initials>MB</Initials><AffiliationInfo><Affiliation>National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA. Electronic address: Kadiiska@niehs.nih.gov.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Basu</LastName><ForeName>Samar</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, Uppsala University, Uppsala, Sweden; Biochemistry, Molecular Biology and Nutrition Department, University of Auvergne, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brot</LastName><ForeName>Nathan</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cooper</LastName><ForeName>Christopher</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saari Csallany</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Davies</LastName><ForeName>Michael J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>The Heart Research Institute, University of Sydney, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>George</LastName><ForeName>Magdalene M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Rush University Medical Center, Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Murray</LastName><ForeName>Dennis M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>Northwest Life Science Specialties, LLC., Vancouver, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jackson Roberts</LastName><ForeName>L</ForeName><Initials>L</Initials><Suffix>2nd</Suffix><AffiliationInfo><Affiliation>Department of Pharmacology and Medicine, Vanderbilt University, Nashville, TN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shigenaga</LastName><ForeName>Mark K</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>Children's Hospital Oakland Research Institute, Oakland, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sohal</LastName><ForeName>Rajindar S</ForeName><Initials>RS</Initials><AffiliationInfo><Affiliation>University of Southern California, Los Angeles, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stocker</LastName><ForeName>Roland</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Victor Chang Cardiac Research Institute, Darlinghurst, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van Thiel</LastName><ForeName>David H</ForeName><Initials>DH</Initials><AffiliationInfo><Affiliation>Rush University Medical Center, Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wiswedel</LastName><ForeName>Ingrid</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Otto-von-Guericke-University, Magdeburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hatch</LastName><ForeName>Gary E</ForeName><Initials>GE</Initials><AffiliationInfo><Affiliation>United States Environmental Protection Agency, Research Triangle Park, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mason</LastName><ForeName>Ronald P</ForeName><Initials>RP</Initials><AffiliationInfo><Affiliation>National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>ZIA ES048012-15</GrantID><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>04</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Free Radic Biol Med</MedlineTA><NlmUniqueID>8709159</NlmUniqueID><ISSNLinking>0891-5849</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008054">Lipid Peroxides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008055">Lipids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011506">Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>27415-26-5</RegistryNumber><NameOfSubstance UI="C075750">8-epi-prostaglandin F2alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>4Y8F71G49Q</RegistryNumber><NameOfSubstance UI="D008315">Malondialdehyde</NameOfSubstance></Chemical><Chemical><RegistryNumber>66H7ZZK23N</RegistryNumber><NameOfSubstance UI="D010126">Ozone</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-49-2</RegistryNumber><NameOfSubstance UI="D004247">DNA</NameOfSubstance></Chemical><Chemical><RegistryNumber>AE28F7PNPL</RegistryNumber><NameOfSubstance UI="D008715">Methionine</NameOfSubstance></Chemical><Chemical><RegistryNumber>B7IN85G1HY</RegistryNumber><NameOfSubstance UI="D015237">Dinoprost</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections 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