Myocardial deformation and twist mechanics in adults with metabolic syndrome: impact of cumulative metabolic burden.
Identifieur interne : 003A76 ( PubMed/Corpus ); précédent : 003A75; suivant : 003A77Myocardial deformation and twist mechanics in adults with metabolic syndrome: impact of cumulative metabolic burden.
Auteurs : Edward Crendal ; Guillaume Walther ; Agnes Vinet ; Frédéric Dutheil ; Geraldine Naughton ; Bruno Lesourd ; Robert Chapier ; Thomas Rupp ; Daniel Courteix ; Philippe ObertSource :
- Obesity (Silver Spring, Md.) [ 1930-739X ] ; 2013.
English descriptors
- KwdEn :
- Aged, Case-Control Studies, Cross-Sectional Studies, Diabetes Mellitus, Type 2 (complications), Diabetes Mellitus, Type 2 (physiopathology), Diastole (physiology), Echocardiography, Female, Hemoglobin A, Glycosylated (metabolism), Humans, Hypertension (complications), Hypertension (physiopathology), Hypertrophy, Left Ventricular (etiology), Hypertrophy, Left Ventricular (physiopathology), Insulin Resistance, Male, Metabolic Syndrome X (complications), Metabolic Syndrome X (physiopathology), Middle Aged, Myocardium (pathology), Obesity (complications), Obesity (physiopathology), Systole (physiology), Tumor Necrosis Factor-alpha (blood).
- MESH :
- chemical , blood : Tumor Necrosis Factor-alpha.
- chemical , metabolism : Hemoglobin A, Glycosylated.
- complications : Diabetes Mellitus, Type 2, Hypertension, Metabolic Syndrome X, Obesity.
- etiology : Hypertrophy, Left Ventricular.
- pathology : Myocardium.
- physiology : Diastole, Systole.
- physiopathology : Diabetes Mellitus, Type 2, Hypertension, Hypertrophy, Left Ventricular, Metabolic Syndrome X, Obesity.
- Aged, Case-Control Studies, Cross-Sectional Studies, Echocardiography, Female, Humans, Insulin Resistance, Male, Middle Aged.
Abstract
The aim of the study is to characterize left ventricular (LV) myocardial mechanics in adults with metabolic syndrome (MetS), and elucidate the effects of multiple risk-factors on myocardial function using speckle tracking echocardiography (STE); a more sensitive method than conventional echocardiography for detecting subclinical myocardial dysfunction.
DOI: 10.1002/oby.20537
PubMed: 23804526
Links to Exploration step
pubmed:23804526Le document en format XML
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School of Exercise Science, Australian Catholic University, Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Walther, Guillaume" sort="Walther, Guillaume" uniqKey="Walther G" first="Guillaume" last="Walther">Guillaume Walther</name></author><author><name sortKey="Vinet, Agnes" sort="Vinet, Agnes" uniqKey="Vinet A" first="Agnes" last="Vinet">Agnes Vinet</name></author><author><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frédéric" last="Dutheil">Frédéric Dutheil</name></author><author><name sortKey="Naughton, Geraldine" sort="Naughton, Geraldine" uniqKey="Naughton G" first="Geraldine" last="Naughton">Geraldine Naughton</name></author><author><name sortKey="Lesourd, Bruno" sort="Lesourd, Bruno" uniqKey="Lesourd B" first="Bruno" last="Lesourd">Bruno Lesourd</name></author><author><name sortKey="Chapier, Robert" sort="Chapier, Robert" uniqKey="Chapier R" first="Robert" last="Chapier">Robert Chapier</name></author><author><name sortKey="Rupp, Thomas" sort="Rupp, Thomas" uniqKey="Rupp T" first="Thomas" last="Rupp">Thomas Rupp</name></author><author><name sortKey="Courteix, Daniel" sort="Courteix, Daniel" uniqKey="Courteix D" first="Daniel" last="Courteix">Daniel Courteix</name></author><author><name sortKey="Obert, Philippe" sort="Obert, Philippe" uniqKey="Obert P" first="Philippe" last="Obert">Philippe Obert</name></author></analytic><series><title level="j">Obesity (Silver Spring, Md.)</title><idno type="eISSN">1930-739X</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Cross-Sectional Studies</term><term>Diabetes Mellitus, Type 2 (complications)</term><term>Diabetes Mellitus, Type 2 (physiopathology)</term><term>Diastole (physiology)</term><term>Echocardiography</term><term>Female</term><term>Hemoglobin A, Glycosylated (metabolism)</term><term>Humans</term><term>Hypertension (complications)</term><term>Hypertension (physiopathology)</term><term>Hypertrophy, Left Ventricular (etiology)</term><term>Hypertrophy, Left Ventricular (physiopathology)</term><term>Insulin Resistance</term><term>Male</term><term>Metabolic Syndrome X (complications)</term><term>Metabolic Syndrome X (physiopathology)</term><term>Middle Aged</term><term>Myocardium (pathology)</term><term>Obesity (complications)</term><term>Obesity (physiopathology)</term><term>Systole (physiology)</term><term>Tumor Necrosis Factor-alpha (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hemoglobin A, Glycosylated</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Diabetes Mellitus, Type 2</term><term>Hypertension</term><term>Metabolic Syndrome X</term><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hypertrophy, Left Ventricular</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Myocardium</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Diastole</term><term>Systole</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Diabetes Mellitus, Type 2</term><term>Hypertension</term><term>Hypertrophy, Left Ventricular</term><term>Metabolic Syndrome X</term><term>Obesity</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Cross-Sectional Studies</term><term>Echocardiography</term><term>Female</term><term>Humans</term><term>Insulin Resistance</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of the study is to characterize left ventricular (LV) myocardial mechanics in adults with metabolic syndrome (MetS), and elucidate the effects of multiple risk-factors on myocardial function using speckle tracking echocardiography (STE); a more sensitive method than conventional echocardiography for detecting subclinical myocardial dysfunction.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23804526</PMID><DateCreated><Year>2013</Year><Month>12</Month><Day>04</Day></DateCreated><DateCompleted><Year>2014</Year><Month>08</Month><Day>11</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1930-739X</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>12</Issue><PubDate><Year>2013</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Obesity (Silver Spring, Md.)</Title><ISOAbbreviation>Obesity (Silver Spring)</ISOAbbreviation></Journal><ArticleTitle>Myocardial deformation and twist mechanics in adults with metabolic syndrome: impact of cumulative metabolic burden.</ArticleTitle><Pagination><MedlinePgn>E679-86</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/oby.20537</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The aim of the study is to characterize left ventricular (LV) myocardial mechanics in adults with metabolic syndrome (MetS), and elucidate the effects of multiple risk-factors on myocardial function using speckle tracking echocardiography (STE); a more sensitive method than conventional echocardiography for detecting subclinical myocardial dysfunction.</AbstractText><AbstractText Label="DESIGN AND METHODS" NlmCategory="METHODS">Cross-sectional analyses of 92 adults (50-70 years) with MetS, and 50 healthy controls included conventional echocardiography, blood biochemistry, and STE-derived myocardial longitudinal, circumferential, and twist mechanics.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Using conventional measures, MetS participants revealed LV hypertrophy and reduced diastolic function compared with controls, while systolic function was preserved. From STE, MetS participants showed attenuated longitudinal strain (-16.8% ± 2.8% vs. -20.6% ± 2.7%), and both diastolic (1.1 ± 0.2 vs. 1.4 ± 0.3 s s(-1) ) and systolic (-1.0 ± 0.1 vs. -1.2 ± 0.2 s s(-1) ) strain rate (SR). Circumferential strain, SR, and twist mechanics did not differ. Participants with the highest number of MetS factors or diabetes demonstrated the greatest reduction in longitudinal strain and SR. Abdominal obesity, TNF-α, HbA1c , and systolic dyssynchrony explained 48% of impairment in longitudinal strain.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Impaired longitudinal myocardial diastolic and systolic function, but preserved circumferential function and twist mechanics were found in MetS participants, indicative of altered subendocardial function. This dysfunction was best predicted by abdominal obesity, inflammation, glucose-intolerance, and systolic dyssynchrony.</AbstractText><CopyrightInformation>Copyright © 2013 The Obesity Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Crendal</LastName><ForeName>Edward</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Avignon University, LAPEC EA4278, Avignon, France; School of Exercise Science, Australian Catholic University, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walther</LastName><ForeName>Guillaume</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Vinet</LastName><ForeName>Agnes</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Dutheil</LastName><ForeName>Frédéric</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Naughton</LastName><ForeName>Geraldine</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Lesourd</LastName><ForeName>Bruno</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Chapier</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Rupp</LastName><ForeName>Thomas</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Courteix</LastName><ForeName>Daniel</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Obert</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>08</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Obesity (Silver Spring)</MedlineTA><NlmUniqueID>101264860</NlmUniqueID><ISSNLinking>1930-7381</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006442">Hemoglobin A, Glycosylated</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C517652">hemoglobin A1c protein, human</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003924" MajorTopicYN="N">Diabetes Mellitus, Type 2</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003971" MajorTopicYN="N">Diastole</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004452" MajorTopicYN="N">Echocardiography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006442" MajorTopicYN="N">Hemoglobin A, Glycosylated</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006973" MajorTopicYN="N">Hypertension</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017379" MajorTopicYN="N">Hypertrophy, Left Ventricular</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007333" MajorTopicYN="N">Insulin Resistance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D024821" MajorTopicYN="N">Metabolic Syndrome X</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009206" MajorTopicYN="N">Myocardium</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009765" MajorTopicYN="N">Obesity</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013599" MajorTopicYN="N">Systole</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>12</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>05</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>6</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>6</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>8</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23804526</ArticleId><ArticleId IdType="doi">10.1002/oby.20537</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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