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Common variant at 16p11.2 conferring risk of psychosis.

Identifieur interne : 003A59 ( PubMed/Corpus ); précédent : 003A58; suivant : 003A60

Common variant at 16p11.2 conferring risk of psychosis.

Auteurs : S. Steinberg ; S. De Jong ; M. Mattheisen ; J. Costas ; D. Demontis ; S. Jamain ; O P H. Pietil Inen ; K. Lin ; S. Papiol ; J. Huttenlocher ; E. Sigurdsson ; E. Vassos ; I. Giegling ; R. Breuer ; G. Fraser ; N. Walker ; I. Melle ; S. Djurovic ; I. Agartz ; A. Tuulio-Henriksson ; J. Suvisaari ; J. Lönnqvist ; T. Paunio ; L. Olsen ; T. Hansen ; A. Ingason ; M. Pirinen ; E. Strengman ; D M Hougaard ; T. Orntoft ; M. Didriksen ; M V Hollegaard ; M. Nordentoft ; L. Abramova ; V. Kaleda ; M. Arrojo ; J. Sanjuán ; C. Arango ; B. Etain ; F. Bellivier ; A. Méary ; F. Schürhoff ; A. Szoke ; M. Ribolsi ; V. Magni ; A. Siracusano ; S. Sperling ; M. Rossner ; C. Christiansen ; L A Kiemeney ; B. Franke ; L H Van Den Berg ; J. Veldink ; S. Curran ; P. Bolton ; M. Poot ; W. Staal ; K. Rehnstrom ; H. Kilpinen ; C M Freitag ; J. Meyer ; P. Magnusson ; E. Saemundsen ; I. Martsenkovsky ; I. Bikshaieva ; I. Martsenkovska ; O. Vashchenko ; M. Raleva ; K. Paketchieva ; B. Stefanovski ; N. Durmishi ; M. Pejovic Milovancevic ; D. Lecic Tosevski ; T. Silagadze ; N. Naneishvili ; N. Mikeladze ; S. Surguladze ; J B Vincent ; A. Farmer ; P B Mitchell ; A. Wright ; P R Schofield ; J M Fullerton ; G W Montgomery ; N G Martin ; I A Rubino ; R. Van Winkel ; G. Kenis ; M. De Hert ; J M Réthelyi ; I. Bitter ; L. Terenius ; E G Jönsson ; S. Bakker ; J. Van Os ; A. Jablensky ; M. Leboyer ; E. Bramon ; J. Powell ; R. Murray ; A. Corvin ; M. Gill ; D. Morris ; F A O'Neill ; K. Kendler ; B. Riley ; N. Craddock ; M J Owen ; M C O'Donovan ; U. Thorsteinsdottir ; A. Kong ; H. Ehrenreich ; A. Carracedo ; V. Golimbet ; O A Andreassen ; A D B Rglum ; O. Mors ; P B Mortensen ; T. Werge ; R A Ophoff ; M M Nöthen ; M. Rietschel ; S. Cichon ; M. Ruggeri ; S. Tosato ; A. Palotie ; D. St Clair ; D. Rujescu ; D A Collier ; H. Stefansson ; K. Stefansson

Source :

RBID : pubmed:23164818

English descriptors

Abstract

Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18 206 cases and 42 536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46 160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T]; odds ratio=1.08; P=6.6 × 10(-11)). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22 651 additional Icelanders).

DOI: 10.1038/mp.2012.157
PubMed: 23164818

Links to Exploration step

pubmed:23164818

Le document en format XML

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<name sortKey="Steinberg, S" sort="Steinberg, S" uniqKey="Steinberg S" first="S" last="Steinberg">S. Steinberg</name>
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<nlm:affiliation>deCODE genetics, Reykjavik, Iceland.</nlm:affiliation>
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<name sortKey="De Jong, S" sort="De Jong, S" uniqKey="De Jong S" first="S" last="De Jong">S. De Jong</name>
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<nlm:affiliation>Center for Neurobehavioral Genetics, UCLA, Los Angeles, CA, USA.</nlm:affiliation>
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<name sortKey="Mattheisen, M" sort="Mattheisen, M" uniqKey="Mattheisen M" first="M" last="Mattheisen">M. Mattheisen</name>
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<nlm:affiliation>1] Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Institute for Genomic Mathematics, University of Bonn, Bonn, Germany [3] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.</nlm:affiliation>
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<name sortKey="Costas, J" sort="Costas, J" uniqKey="Costas J" first="J" last="Costas">J. Costas</name>
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<nlm:affiliation>Galician Foundation of Genomic Medicine-SERGAS, Complexo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, Spain.</nlm:affiliation>
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<name sortKey="Demontis, D" sort="Demontis, D" uniqKey="Demontis D" first="D" last="Demontis">D. Demontis</name>
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<nlm:affiliation>1] Department of Biomedicine, Human Genetics, and Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark [2] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.</nlm:affiliation>
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<name sortKey="Jamain, S" sort="Jamain, S" uniqKey="Jamain S" first="S" last="Jamain">S. Jamain</name>
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<nlm:affiliation>1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France.</nlm:affiliation>
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<name sortKey="Pietil Inen, O P H" sort="Pietil Inen, O P H" uniqKey="Pietil Inen O" first="O P H" last="Pietil Inen">O P H. Pietil Inen</name>
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<nlm:affiliation>1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland [3] Wellcome Trust Sanger Institute, Cambridge, UK.</nlm:affiliation>
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<name sortKey="Lin, K" sort="Lin, K" uniqKey="Lin K" first="K" last="Lin">K. Lin</name>
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<nlm:affiliation>Department of Neuroscience, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King's College, London, UK.</nlm:affiliation>
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<name sortKey="Papiol, S" sort="Papiol, S" uniqKey="Papiol S" first="S" last="Papiol">S. Papiol</name>
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<nlm:affiliation>1] DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany [2] Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.</nlm:affiliation>
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<name sortKey="Huttenlocher, J" sort="Huttenlocher, J" uniqKey="Huttenlocher J" first="J" last="Huttenlocher">J. Huttenlocher</name>
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<nlm:affiliation>1] deCODE genetics, Reykjavik, Iceland [2] Department of Medical Genetics, Institute of Human Genetics, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
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<name sortKey="Sigurdsson, E" sort="Sigurdsson, E" uniqKey="Sigurdsson E" first="E" last="Sigurdsson">E. Sigurdsson</name>
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<nlm:affiliation>1] Department of Psychiatry, National University Hospital, Reykjavik, Iceland [2] School of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:affiliation>
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<name sortKey="Vassos, E" sort="Vassos, E" uniqKey="Vassos E" first="E" last="Vassos">E. Vassos</name>
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<nlm:affiliation>Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK.</nlm:affiliation>
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<name sortKey="Giegling, I" sort="Giegling, I" uniqKey="Giegling I" first="I" last="Giegling">I. Giegling</name>
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<nlm:affiliation>Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany.</nlm:affiliation>
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<name sortKey="Breuer, R" sort="Breuer, R" uniqKey="Breuer R" first="R" last="Breuer">R. Breuer</name>
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<nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.</nlm:affiliation>
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<name sortKey="Fraser, G" sort="Fraser, G" uniqKey="Fraser G" first="G" last="Fraser">G. Fraser</name>
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<nlm:affiliation>Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen, UK.</nlm:affiliation>
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<name sortKey="Walker, N" sort="Walker, N" uniqKey="Walker N" first="N" last="Walker">N. Walker</name>
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<nlm:affiliation>Ravenscraig Hospital, Greenock, UK.</nlm:affiliation>
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<name sortKey="Melle, I" sort="Melle, I" uniqKey="Melle I" first="I" last="Melle">I. Melle</name>
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<nlm:affiliation>Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway.</nlm:affiliation>
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<name sortKey="Djurovic, S" sort="Djurovic, S" uniqKey="Djurovic S" first="S" last="Djurovic">S. Djurovic</name>
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<nlm:affiliation>Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway.</nlm:affiliation>
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<name sortKey="Agartz, I" sort="Agartz, I" uniqKey="Agartz I" first="I" last="Agartz">I. Agartz</name>
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<nlm:affiliation>Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Tuulio Henriksson, A" sort="Tuulio Henriksson, A" uniqKey="Tuulio Henriksson A" first="A" last="Tuulio-Henriksson">A. Tuulio-Henriksson</name>
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<nlm:affiliation>Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation>
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<name sortKey="Suvisaari, J" sort="Suvisaari, J" uniqKey="Suvisaari J" first="J" last="Suvisaari">J. Suvisaari</name>
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<nlm:affiliation>Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation>
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<name sortKey="Lonnqvist, J" sort="Lonnqvist, J" uniqKey="Lonnqvist J" first="J" last="Lönnqvist">J. Lönnqvist</name>
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<nlm:affiliation>Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation>
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<author>
<name sortKey="Paunio, T" sort="Paunio, T" uniqKey="Paunio T" first="T" last="Paunio">T. Paunio</name>
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<nlm:affiliation>Public Health Genomics Unit, National Institute for Health and Welfare THL, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation>
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<name sortKey="Olsen, L" sort="Olsen, L" uniqKey="Olsen L" first="L" last="Olsen">L. Olsen</name>
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<nlm:affiliation>Institute of Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University, Roskilde, Denmark.</nlm:affiliation>
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<name sortKey="Hansen, T" sort="Hansen, T" uniqKey="Hansen T" first="T" last="Hansen">T. Hansen</name>
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<nlm:affiliation>Institute of Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University, Roskilde, Denmark.</nlm:affiliation>
</affiliation>
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<name sortKey="Ingason, A" sort="Ingason, A" uniqKey="Ingason A" first="A" last="Ingason">A. Ingason</name>
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<nlm:affiliation>Institute of Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University, Roskilde, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Pirinen, M" sort="Pirinen, M" uniqKey="Pirinen M" first="M" last="Pirinen">M. Pirinen</name>
<affiliation>
<nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Strengman, E" sort="Strengman, E" uniqKey="Strengman E" first="E" last="Strengman">E. Strengman</name>
<affiliation>
<nlm:affiliation>Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Hougaard, D M" sort="Hougaard, D M" uniqKey="Hougaard D" first="D M" last="Hougaard">D M Hougaard</name>
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<nlm:affiliation>Section of Neonatal Screening and Hormones, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen, Denmark.</nlm:affiliation>
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<name sortKey="Orntoft, T" sort="Orntoft, T" uniqKey="Orntoft T" first="T" last="Orntoft">T. Orntoft</name>
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<nlm:affiliation>Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Didriksen, M" sort="Didriksen, M" uniqKey="Didriksen M" first="M" last="Didriksen">M. Didriksen</name>
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<nlm:affiliation>Synaptic transmission, H. Lundbeck A/S, Copenhagen, Denmark.</nlm:affiliation>
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<author>
<name sortKey="Hollegaard, M V" sort="Hollegaard, M V" uniqKey="Hollegaard M" first="M V" last="Hollegaard">M V Hollegaard</name>
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<nlm:affiliation>Section of Neonatal Screening and Hormones, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen, Denmark.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Nordentoft, M" sort="Nordentoft, M" uniqKey="Nordentoft M" first="M" last="Nordentoft">M. Nordentoft</name>
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<nlm:affiliation>1] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [2] Psychiatric Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Abramova, L" sort="Abramova, L" uniqKey="Abramova L" first="L" last="Abramova">L. Abramova</name>
<affiliation>
<nlm:affiliation>Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Kaleda, V" sort="Kaleda, V" uniqKey="Kaleda V" first="V" last="Kaleda">V. Kaleda</name>
<affiliation>
<nlm:affiliation>Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Arrojo, M" sort="Arrojo, M" uniqKey="Arrojo M" first="M" last="Arrojo">M. Arrojo</name>
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<nlm:affiliation>Service of Psychiatry, Complexo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, Spain.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Sanjuan, J" sort="Sanjuan, J" uniqKey="Sanjuan J" first="J" last="Sanjuán">J. Sanjuán</name>
<affiliation>
<nlm:affiliation>Unit of Psychiatry, Faculty of Medicine, University of Valencia, Network Center of Biomedical Research on Mental Health (CIBERSAM), Valencia, Spain.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Arango, C" sort="Arango, C" uniqKey="Arango C" first="C" last="Arango">C. Arango</name>
<affiliation>
<nlm:affiliation>Hospital General Universitario Gregorio Marañón, IiSGM, Universidad Complutense, CIBERSAM, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Etain, B" sort="Etain, B" uniqKey="Etain B" first="B" last="Etain">B. Etain</name>
<affiliation>
<nlm:affiliation>1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Bellivier, F" sort="Bellivier, F" uniqKey="Bellivier F" first="F" last="Bellivier">F. Bellivier</name>
<affiliation>
<nlm:affiliation>1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France [4] Université Paris Est, Faculté de Médecine, Creteil, France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Meary, A" sort="Meary, A" uniqKey="Meary A" first="A" last="Méary">A. Méary</name>
<affiliation>
<nlm:affiliation>1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Schurhoff, F" sort="Schurhoff, F" uniqKey="Schurhoff F" first="F" last="Schürhoff">F. Schürhoff</name>
<affiliation>
<nlm:affiliation>1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France [4] Université Paris Est, Faculté de Médecine, Creteil, France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Szoke, A" sort="Szoke, A" uniqKey="Szoke A" first="A" last="Szoke">A. Szoke</name>
<affiliation>
<nlm:affiliation>1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Ribolsi, M" sort="Ribolsi, M" uniqKey="Ribolsi M" first="M" last="Ribolsi">M. Ribolsi</name>
<affiliation>
<nlm:affiliation>Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Magni, V" sort="Magni, V" uniqKey="Magni V" first="V" last="Magni">V. Magni</name>
<affiliation>
<nlm:affiliation>Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Siracusano, A" sort="Siracusano, A" uniqKey="Siracusano A" first="A" last="Siracusano">A. Siracusano</name>
<affiliation>
<nlm:affiliation>Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Sperling, S" sort="Sperling, S" uniqKey="Sperling S" first="S" last="Sperling">S. Sperling</name>
<affiliation>
<nlm:affiliation>Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Rossner, M" sort="Rossner, M" uniqKey="Rossner M" first="M" last="Rossner">M. Rossner</name>
<affiliation>
<nlm:affiliation>1] DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany [2] Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Christiansen, C" sort="Christiansen, C" uniqKey="Christiansen C" first="C" last="Christiansen">C. Christiansen</name>
<affiliation>
<nlm:affiliation>Nordic Bioscience, Herlev, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Kiemeney, L A" sort="Kiemeney, L A" uniqKey="Kiemeney L" first="L A" last="Kiemeney">L A Kiemeney</name>
<affiliation>
<nlm:affiliation>Department of Epidemiology and Biostatistics and Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Franke, B" sort="Franke, B" uniqKey="Franke B" first="B" last="Franke">B. Franke</name>
<affiliation>
<nlm:affiliation>Departments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Van Den Berg, L H" sort="Van Den Berg, L H" uniqKey="Van Den Berg L" first="L H" last="Van Den Berg">L H Van Den Berg</name>
<affiliation>
<nlm:affiliation>Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Veldink, J" sort="Veldink, J" uniqKey="Veldink J" first="J" last="Veldink">J. Veldink</name>
<affiliation>
<nlm:affiliation>Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Curran, S" sort="Curran, S" uniqKey="Curran S" first="S" last="Curran">S. Curran</name>
<affiliation>
<nlm:affiliation>1] Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK [2] Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College, London UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Bolton, P" sort="Bolton, P" uniqKey="Bolton P" first="P" last="Bolton">P. Bolton</name>
<affiliation>
<nlm:affiliation>1] Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK [2] Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College, London UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Poot, M" sort="Poot, M" uniqKey="Poot M" first="M" last="Poot">M. Poot</name>
<affiliation>
<nlm:affiliation>Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Staal, W" sort="Staal, W" uniqKey="Staal W" first="W" last="Staal">W. Staal</name>
<affiliation>
<nlm:affiliation>Department of Cognitive Neuroscience, Radboud University Nijmegen, Nijmegen, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Rehnstrom, K" sort="Rehnstrom, K" uniqKey="Rehnstrom K" first="K" last="Rehnstrom">K. Rehnstrom</name>
<affiliation>
<nlm:affiliation>1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Wellcome Trust Sanger Institute, Cambridge, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Kilpinen, H" sort="Kilpinen, H" uniqKey="Kilpinen H" first="H" last="Kilpinen">H. Kilpinen</name>
<affiliation>
<nlm:affiliation>1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Wellcome Trust Sanger Institute, Cambridge, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Freitag, C M" sort="Freitag, C M" uniqKey="Freitag C" first="C M" last="Freitag">C M Freitag</name>
<affiliation>
<nlm:affiliation>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Frankfurt am Main, Frankfurt am Main, Germany.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Meyer, J" sort="Meyer, J" uniqKey="Meyer J" first="J" last="Meyer">J. Meyer</name>
<affiliation>
<nlm:affiliation>Department of Neurobehavioural Genetics, University of Trier, Trier, Germany.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Magnusson, P" sort="Magnusson, P" uniqKey="Magnusson P" first="P" last="Magnusson">P. Magnusson</name>
<affiliation>
<nlm:affiliation>Department of Child and Adolescent Psychiatry, National University Hospital, Reykjavik, Iceland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Saemundsen, E" sort="Saemundsen, E" uniqKey="Saemundsen E" first="E" last="Saemundsen">E. Saemundsen</name>
<affiliation>
<nlm:affiliation>State Diagnostic and Counseling Centre, Kopavogur, Iceland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Martsenkovsky, I" sort="Martsenkovsky, I" uniqKey="Martsenkovsky I" first="I" last="Martsenkovsky">I. Martsenkovsky</name>
<affiliation>
<nlm:affiliation>Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Bikshaieva, I" sort="Bikshaieva, I" uniqKey="Bikshaieva I" first="I" last="Bikshaieva">I. Bikshaieva</name>
<affiliation>
<nlm:affiliation>Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Martsenkovska, I" sort="Martsenkovska, I" uniqKey="Martsenkovska I" first="I" last="Martsenkovska">I. Martsenkovska</name>
<affiliation>
<nlm:affiliation>Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Vashchenko, O" sort="Vashchenko, O" uniqKey="Vashchenko O" first="O" last="Vashchenko">O. Vashchenko</name>
<affiliation>
<nlm:affiliation>Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Raleva, M" sort="Raleva, M" uniqKey="Raleva M" first="M" last="Raleva">M. Raleva</name>
<affiliation>
<nlm:affiliation>Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Paketchieva, K" sort="Paketchieva, K" uniqKey="Paketchieva K" first="K" last="Paketchieva">K. Paketchieva</name>
<affiliation>
<nlm:affiliation>Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Stefanovski, B" sort="Stefanovski, B" uniqKey="Stefanovski B" first="B" last="Stefanovski">B. Stefanovski</name>
<affiliation>
<nlm:affiliation>Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Durmishi, N" sort="Durmishi, N" uniqKey="Durmishi N" first="N" last="Durmishi">N. Durmishi</name>
<affiliation>
<nlm:affiliation>Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Pejovic Milovancevic, M" sort="Pejovic Milovancevic, M" uniqKey="Pejovic Milovancevic M" first="M" last="Pejovic Milovancevic">M. Pejovic Milovancevic</name>
<affiliation>
<nlm:affiliation>1] Institute of Mental Health, Belgrade, Serbia [2] Medical Faculty, University of Belgrade, Belgrade, Serbia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Lecic Tosevski, D" sort="Lecic Tosevski, D" uniqKey="Lecic Tosevski D" first="D" last="Lecic Tosevski">D. Lecic Tosevski</name>
<affiliation>
<nlm:affiliation>1] Institute of Mental Health, Belgrade, Serbia [2] Medical Faculty, University of Belgrade, Belgrade, Serbia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Silagadze, T" sort="Silagadze, T" uniqKey="Silagadze T" first="T" last="Silagadze">T. Silagadze</name>
<affiliation>
<nlm:affiliation>Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Naneishvili, N" sort="Naneishvili, N" uniqKey="Naneishvili N" first="N" last="Naneishvili">N. Naneishvili</name>
<affiliation>
<nlm:affiliation>Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Mikeladze, N" sort="Mikeladze, N" uniqKey="Mikeladze N" first="N" last="Mikeladze">N. Mikeladze</name>
<affiliation>
<nlm:affiliation>Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Surguladze, S" sort="Surguladze, S" uniqKey="Surguladze S" first="S" last="Surguladze">S. Surguladze</name>
<affiliation>
<nlm:affiliation>Social and Affective Neuroscience Lab, Ilia State University, Tbilisi, Georgia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Vincent, J B" sort="Vincent, J B" uniqKey="Vincent J" first="J B" last="Vincent">J B Vincent</name>
<affiliation>
<nlm:affiliation>Molecular Neuropsychiatry and Development Laboratory, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Farmer, A" sort="Farmer, A" uniqKey="Farmer A" first="A" last="Farmer">A. Farmer</name>
<affiliation>
<nlm:affiliation>Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Mitchell, P B" sort="Mitchell, P B" uniqKey="Mitchell P" first="P B" last="Mitchell">P B Mitchell</name>
<affiliation>
<nlm:affiliation>1] Black Dog Institute, Prince of Wales Hospital, Randwick, NSW, Australia [2] School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Wright, A" sort="Wright, A" uniqKey="Wright A" first="A" last="Wright">A. Wright</name>
<affiliation>
<nlm:affiliation>1] Black Dog Institute, Prince of Wales Hospital, Randwick, NSW, Australia [2] School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Schofield, P R" sort="Schofield, P R" uniqKey="Schofield P" first="P R" last="Schofield">P R Schofield</name>
<affiliation>
<nlm:affiliation>1] Neuroscience Research Australia, Barker Street, Sydney, NSW, Australia [2] School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Fullerton, J M" sort="Fullerton, J M" uniqKey="Fullerton J" first="J M" last="Fullerton">J M Fullerton</name>
<affiliation>
<nlm:affiliation>1] Neuroscience Research Australia, Barker Street, Sydney, NSW, Australia [2] School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Montgomery, G W" sort="Montgomery, G W" uniqKey="Montgomery G" first="G W" last="Montgomery">G W Montgomery</name>
<affiliation>
<nlm:affiliation>Queensland Institute of Medical Research, Brisbane, QLD, Australia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Martin, N G" sort="Martin, N G" uniqKey="Martin N" first="N G" last="Martin">N G Martin</name>
<affiliation>
<nlm:affiliation>Queensland Institute of Medical Research, Brisbane, QLD, Australia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Rubino, I A" sort="Rubino, I A" uniqKey="Rubino I" first="I A" last="Rubino">I A Rubino</name>
<affiliation>
<nlm:affiliation>Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Van Winkel, R" sort="Van Winkel, R" uniqKey="Van Winkel R" first="R" last="Van Winkel">R. Van Winkel</name>
<affiliation>
<nlm:affiliation>1] University Psychiatric Center, Catholic University Leuven, Kortenberg, Belgium [2] Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience (EURON), South Limburg Mental Health Research and Teaching Network (SEARCH), Maastricht University Medical Center, Maastricht, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Kenis, G" sort="Kenis, G" uniqKey="Kenis G" first="G" last="Kenis">G. Kenis</name>
<affiliation>
<nlm:affiliation>Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience (EURON), South Limburg Mental Health Research and Teaching Network (SEARCH), Maastricht University Medical Center, Maastricht, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="De Hert, M" sort="De Hert, M" uniqKey="De Hert M" first="M" last="De Hert">M. De Hert</name>
<affiliation>
<nlm:affiliation>University Psychiatric Center, Catholic University Leuven, Kortenberg, Belgium.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Rethelyi, J M" sort="Rethelyi, J M" uniqKey="Rethelyi J" first="J M" last="Réthelyi">J M Réthelyi</name>
<affiliation>
<nlm:affiliation>Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Bitter, I" sort="Bitter, I" uniqKey="Bitter I" first="I" last="Bitter">I. Bitter</name>
<affiliation>
<nlm:affiliation>Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Terenius, L" sort="Terenius, L" uniqKey="Terenius L" first="L" last="Terenius">L. Terenius</name>
<affiliation>
<nlm:affiliation>Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Jonsson, E G" sort="Jonsson, E G" uniqKey="Jonsson E" first="E G" last="Jönsson">E G Jönsson</name>
<affiliation>
<nlm:affiliation>Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Bakker, S" sort="Bakker, S" uniqKey="Bakker S" first="S" last="Bakker">S. Bakker</name>
<affiliation>
<nlm:affiliation>Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Van Os, J" sort="Van Os, J" uniqKey="Van Os J" first="J" last="Van Os">J. Van Os</name>
<affiliation>
<nlm:affiliation>Department of Psychiatry, Maastricht University Medical Centre, Maastricht, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Jablensky, A" sort="Jablensky, A" uniqKey="Jablensky A" first="A" last="Jablensky">A. Jablensky</name>
<affiliation>
<nlm:affiliation>Centre for Clinical Research in Neuropsychiatry (CCRN), Graylands Hospital, the University of Western Australia, Perth, WA, Australia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Leboyer, M" sort="Leboyer, M" uniqKey="Leboyer M" first="M" last="Leboyer">M. Leboyer</name>
<affiliation>
<nlm:affiliation>1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France [4] Université Paris Est, Faculté de Médecine, Creteil, France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Bramon, E" sort="Bramon, E" uniqKey="Bramon E" first="E" last="Bramon">E. Bramon</name>
<affiliation>
<nlm:affiliation>Mental Health Sciences Unit and Institute of Cognitive Neuroscience, University College London, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Powell, J" sort="Powell, J" uniqKey="Powell J" first="J" last="Powell">J. Powell</name>
<affiliation>
<nlm:affiliation>Department of Neuroscience, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King's College, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Murray, R" sort="Murray, R" uniqKey="Murray R" first="R" last="Murray">R. Murray</name>
<affiliation>
<nlm:affiliation>Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King's College, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Corvin, A" sort="Corvin, A" uniqKey="Corvin A" first="A" last="Corvin">A. Corvin</name>
<affiliation>
<nlm:affiliation>Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Gill, M" sort="Gill, M" uniqKey="Gill M" first="M" last="Gill">M. Gill</name>
<affiliation>
<nlm:affiliation>Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Morris, D" sort="Morris, D" uniqKey="Morris D" first="D" last="Morris">D. Morris</name>
<affiliation>
<nlm:affiliation>Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="O Neill, F A" sort="O Neill, F A" uniqKey="O Neill F" first="F A" last="O'Neill">F A O'Neill</name>
<affiliation>
<nlm:affiliation>Department of Psychiatry, Queens University, Belfast, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Kendler, K" sort="Kendler, K" uniqKey="Kendler K" first="K" last="Kendler">K. Kendler</name>
<affiliation>
<nlm:affiliation>1] Department of Human Genetics, Virginia Commonwealth University, Richmond, VA, USA [2] Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA [3] Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Riley, B" sort="Riley, B" uniqKey="Riley B" first="B" last="Riley">B. Riley</name>
<affiliation>
<nlm:affiliation>1] Department of Human Genetics, Virginia Commonwealth University, Richmond, VA, USA [2] Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA [3] Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Craddock, N" sort="Craddock, N" uniqKey="Craddock N" first="N" last="Craddock">N. Craddock</name>
<affiliation>
<nlm:affiliation>MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Owen, M J" sort="Owen, M J" uniqKey="Owen M" first="M J" last="Owen">M J Owen</name>
<affiliation>
<nlm:affiliation>MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="O Donovan, M C" sort="O Donovan, M C" uniqKey="O Donovan M" first="M C" last="O'Donovan">M C O'Donovan</name>
<affiliation>
<nlm:affiliation>MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Thorsteinsdottir, U" sort="Thorsteinsdottir, U" uniqKey="Thorsteinsdottir U" first="U" last="Thorsteinsdottir">U. Thorsteinsdottir</name>
<affiliation>
<nlm:affiliation>1] deCODE genetics, Reykjavik, Iceland [2] School of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Kong, A" sort="Kong, A" uniqKey="Kong A" first="A" last="Kong">A. Kong</name>
<affiliation>
<nlm:affiliation>deCODE genetics, Reykjavik, Iceland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Ehrenreich, H" sort="Ehrenreich, H" uniqKey="Ehrenreich H" first="H" last="Ehrenreich">H. Ehrenreich</name>
<affiliation>
<nlm:affiliation>1] DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany [2] Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Carracedo, A" sort="Carracedo, A" uniqKey="Carracedo A" first="A" last="Carracedo">A. Carracedo</name>
<affiliation>
<nlm:affiliation>Genomic Medicine Group - Galician Foundation of Genomic Medicine-Biomedical Network Research Centre on Rare Diseases (CIBERER), University of Santiago de Compostela, Santiago de Compostela, Spain.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Golimbet, V" sort="Golimbet, V" uniqKey="Golimbet V" first="V" last="Golimbet">V. Golimbet</name>
<affiliation>
<nlm:affiliation>Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Andreassen, O A" sort="Andreassen, O A" uniqKey="Andreassen O" first="O A" last="Andreassen">O A Andreassen</name>
<affiliation>
<nlm:affiliation>Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="B Rglum, A D" sort="B Rglum, A D" uniqKey="B Rglum A" first="A D" last="B Rglum">A D B Rglum</name>
<affiliation>
<nlm:affiliation>1] Department of Biomedicine, Human Genetics, and Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark [2] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [3] Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Mors, O" sort="Mors, O" uniqKey="Mors O" first="O" last="Mors">O. Mors</name>
<affiliation>
<nlm:affiliation>1] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [2] Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Mortensen, P B" sort="Mortensen, P B" uniqKey="Mortensen P" first="P B" last="Mortensen">P B Mortensen</name>
<affiliation>
<nlm:affiliation>1] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [2] National Centre for Register-based Research, Aarhus University, Aarhus, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Werge, T" sort="Werge, T" uniqKey="Werge T" first="T" last="Werge">T. Werge</name>
<affiliation>
<nlm:affiliation>1] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [2] Institute of Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University, Roskilde, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Ophoff, R A" sort="Ophoff, R A" uniqKey="Ophoff R" first="R A" last="Ophoff">R A Ophoff</name>
<affiliation>
<nlm:affiliation>1] Center for Neurobehavioral Genetics, UCLA, Los Angeles, CA, USA [2] Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Nothen, M M" sort="Nothen, M M" uniqKey="Nothen M" first="M M" last="Nöthen">M M Nöthen</name>
<affiliation>
<nlm:affiliation>1] German Center for Neurodegenerative Disorders (DZNE), Bonn Germany [2] Institute of Human Genetics, University of Bonn, Bonn Germany.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Rietschel, M" sort="Rietschel, M" uniqKey="Rietschel M" first="M" last="Rietschel">M. Rietschel</name>
<affiliation>
<nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Cichon, S" sort="Cichon, S" uniqKey="Cichon S" first="S" last="Cichon">S. Cichon</name>
<affiliation>
<nlm:affiliation>1] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany [2] Institute of Human Genetics, University of Bonn, Bonn Germany [3] Institute of Neurosciences and Medicine (INM-1), Juelich, Germany.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Ruggeri, M" sort="Ruggeri, M" uniqKey="Ruggeri M" first="M" last="Ruggeri">M. Ruggeri</name>
<affiliation>
<nlm:affiliation>Section of Psychiatry, University of Verona, Verona, Italy.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Tosato, S" sort="Tosato, S" uniqKey="Tosato S" first="S" last="Tosato">S. Tosato</name>
<affiliation>
<nlm:affiliation>Section of Psychiatry, University of Verona, Verona, Italy.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Palotie, A" sort="Palotie, A" uniqKey="Palotie A" first="A" last="Palotie">A. Palotie</name>
<affiliation>
<nlm:affiliation>1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Wellcome Trust Sanger Institute, Cambridge, UK [3] Program in Medical and Population Genetics and Genetic Analysis Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA [4] Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="St Clair, D" sort="St Clair, D" uniqKey="St Clair D" first="D" last="St Clair">D. St Clair</name>
<affiliation>
<nlm:affiliation>Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Rujescu, D" sort="Rujescu, D" uniqKey="Rujescu D" first="D" last="Rujescu">D. Rujescu</name>
<affiliation>
<nlm:affiliation>1] Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany [2] Department of Psychiatry, University of Halle-Wittenberg, Halle, Germany.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Collier, D A" sort="Collier, D A" uniqKey="Collier D" first="D A" last="Collier">D A Collier</name>
<affiliation>
<nlm:affiliation>1] Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK [2] Eli Lilly and Co. Ltd, Erl Wood Manor, Windlesham, Surrey, UK.</nlm:affiliation>
</affiliation>
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<name sortKey="Stefansson, H" sort="Stefansson, H" uniqKey="Stefansson H" first="H" last="Stefansson">H. Stefansson</name>
<affiliation>
<nlm:affiliation>deCODE genetics, Reykjavik, Iceland.</nlm:affiliation>
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<name sortKey="Stefansson, K" sort="Stefansson, K" uniqKey="Stefansson K" first="K" last="Stefansson">K. Stefansson</name>
<affiliation>
<nlm:affiliation>1] deCODE genetics, Reykjavik, Iceland [2] School of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:affiliation>
</affiliation>
</author>
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<idno type="doi">10.1038/mp.2012.157</idno>
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<nlm:affiliation>deCODE genetics, Reykjavik, Iceland.</nlm:affiliation>
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<nlm:affiliation>Center for Neurobehavioral Genetics, UCLA, Los Angeles, CA, USA.</nlm:affiliation>
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<nlm:affiliation>1] Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Institute for Genomic Mathematics, University of Bonn, Bonn, Germany [3] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.</nlm:affiliation>
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<nlm:affiliation>Galician Foundation of Genomic Medicine-SERGAS, Complexo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, Spain.</nlm:affiliation>
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<nlm:affiliation>1] Department of Biomedicine, Human Genetics, and Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark [2] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.</nlm:affiliation>
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<nlm:affiliation>1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France.</nlm:affiliation>
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<affiliation>
<nlm:affiliation>1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland [3] Wellcome Trust Sanger Institute, Cambridge, UK.</nlm:affiliation>
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<name sortKey="Lin, K" sort="Lin, K" uniqKey="Lin K" first="K" last="Lin">K. Lin</name>
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<nlm:affiliation>Department of Neuroscience, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King's College, London, UK.</nlm:affiliation>
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<name sortKey="Papiol, S" sort="Papiol, S" uniqKey="Papiol S" first="S" last="Papiol">S. Papiol</name>
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<nlm:affiliation>1] DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany [2] Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.</nlm:affiliation>
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<nlm:affiliation>1] deCODE genetics, Reykjavik, Iceland [2] Department of Medical Genetics, Institute of Human Genetics, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
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<name sortKey="Sigurdsson, E" sort="Sigurdsson, E" uniqKey="Sigurdsson E" first="E" last="Sigurdsson">E. Sigurdsson</name>
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<nlm:affiliation>1] Department of Psychiatry, National University Hospital, Reykjavik, Iceland [2] School of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:affiliation>
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<nlm:affiliation>Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK.</nlm:affiliation>
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<name sortKey="Giegling, I" sort="Giegling, I" uniqKey="Giegling I" first="I" last="Giegling">I. Giegling</name>
<affiliation>
<nlm:affiliation>Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Breuer, R" sort="Breuer, R" uniqKey="Breuer R" first="R" last="Breuer">R. Breuer</name>
<affiliation>
<nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.</nlm:affiliation>
</affiliation>
</author>
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<name sortKey="Fraser, G" sort="Fraser, G" uniqKey="Fraser G" first="G" last="Fraser">G. Fraser</name>
<affiliation>
<nlm:affiliation>Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Walker, N" sort="Walker, N" uniqKey="Walker N" first="N" last="Walker">N. Walker</name>
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<nlm:affiliation>Ravenscraig Hospital, Greenock, UK.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Melle, I" sort="Melle, I" uniqKey="Melle I" first="I" last="Melle">I. Melle</name>
<affiliation>
<nlm:affiliation>Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway.</nlm:affiliation>
</affiliation>
</author>
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<name sortKey="Djurovic, S" sort="Djurovic, S" uniqKey="Djurovic S" first="S" last="Djurovic">S. Djurovic</name>
<affiliation>
<nlm:affiliation>Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway.</nlm:affiliation>
</affiliation>
</author>
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<name sortKey="Agartz, I" sort="Agartz, I" uniqKey="Agartz I" first="I" last="Agartz">I. Agartz</name>
<affiliation>
<nlm:affiliation>Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway.</nlm:affiliation>
</affiliation>
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<name sortKey="Tuulio Henriksson, A" sort="Tuulio Henriksson, A" uniqKey="Tuulio Henriksson A" first="A" last="Tuulio-Henriksson">A. Tuulio-Henriksson</name>
<affiliation>
<nlm:affiliation>Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Suvisaari, J" sort="Suvisaari, J" uniqKey="Suvisaari J" first="J" last="Suvisaari">J. Suvisaari</name>
<affiliation>
<nlm:affiliation>Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
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<name sortKey="Lonnqvist, J" sort="Lonnqvist, J" uniqKey="Lonnqvist J" first="J" last="Lönnqvist">J. Lönnqvist</name>
<affiliation>
<nlm:affiliation>Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Paunio, T" sort="Paunio, T" uniqKey="Paunio T" first="T" last="Paunio">T. Paunio</name>
<affiliation>
<nlm:affiliation>Public Health Genomics Unit, National Institute for Health and Welfare THL, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
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<affiliation>
<nlm:affiliation>Institute of Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University, Roskilde, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Hansen, T" sort="Hansen, T" uniqKey="Hansen T" first="T" last="Hansen">T. Hansen</name>
<affiliation>
<nlm:affiliation>Institute of Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University, Roskilde, Denmark.</nlm:affiliation>
</affiliation>
</author>
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<name sortKey="Ingason, A" sort="Ingason, A" uniqKey="Ingason A" first="A" last="Ingason">A. Ingason</name>
<affiliation>
<nlm:affiliation>Institute of Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University, Roskilde, Denmark.</nlm:affiliation>
</affiliation>
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<name sortKey="Pirinen, M" sort="Pirinen, M" uniqKey="Pirinen M" first="M" last="Pirinen">M. Pirinen</name>
<affiliation>
<nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:affiliation>
</affiliation>
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<name sortKey="Strengman, E" sort="Strengman, E" uniqKey="Strengman E" first="E" last="Strengman">E. Strengman</name>
<affiliation>
<nlm:affiliation>Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Hougaard, D M" sort="Hougaard, D M" uniqKey="Hougaard D" first="D M" last="Hougaard">D M Hougaard</name>
<affiliation>
<nlm:affiliation>Section of Neonatal Screening and Hormones, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Orntoft, T" sort="Orntoft, T" uniqKey="Orntoft T" first="T" last="Orntoft">T. Orntoft</name>
<affiliation>
<nlm:affiliation>Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Didriksen, M" sort="Didriksen, M" uniqKey="Didriksen M" first="M" last="Didriksen">M. Didriksen</name>
<affiliation>
<nlm:affiliation>Synaptic transmission, H. Lundbeck A/S, Copenhagen, Denmark.</nlm:affiliation>
</affiliation>
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<affiliation>
<nlm:affiliation>Section of Neonatal Screening and Hormones, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Nordentoft, M" sort="Nordentoft, M" uniqKey="Nordentoft M" first="M" last="Nordentoft">M. Nordentoft</name>
<affiliation>
<nlm:affiliation>1] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [2] Psychiatric Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation>
</affiliation>
</author>
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<nlm:affiliation>Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia.</nlm:affiliation>
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<nlm:affiliation>Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia.</nlm:affiliation>
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<nlm:affiliation>Service of Psychiatry, Complexo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, Spain.</nlm:affiliation>
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<nlm:affiliation>Unit of Psychiatry, Faculty of Medicine, University of Valencia, Network Center of Biomedical Research on Mental Health (CIBERSAM), Valencia, Spain.</nlm:affiliation>
</affiliation>
</author>
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<nlm:affiliation>Hospital General Universitario Gregorio Marañón, IiSGM, Universidad Complutense, CIBERSAM, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author>
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<affiliation>
<nlm:affiliation>1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France.</nlm:affiliation>
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<name sortKey="Bellivier, F" sort="Bellivier, F" uniqKey="Bellivier F" first="F" last="Bellivier">F. Bellivier</name>
<affiliation>
<nlm:affiliation>1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France [4] Université Paris Est, Faculté de Médecine, Creteil, France.</nlm:affiliation>
</affiliation>
</author>
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<affiliation>
<nlm:affiliation>1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Schurhoff, F" sort="Schurhoff, F" uniqKey="Schurhoff F" first="F" last="Schürhoff">F. Schürhoff</name>
<affiliation>
<nlm:affiliation>1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France [4] Université Paris Est, Faculté de Médecine, Creteil, France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Szoke, A" sort="Szoke, A" uniqKey="Szoke A" first="A" last="Szoke">A. Szoke</name>
<affiliation>
<nlm:affiliation>1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France.</nlm:affiliation>
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<name sortKey="Ribolsi, M" sort="Ribolsi, M" uniqKey="Ribolsi M" first="M" last="Ribolsi">M. Ribolsi</name>
<affiliation>
<nlm:affiliation>Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Magni, V" sort="Magni, V" uniqKey="Magni V" first="V" last="Magni">V. Magni</name>
<affiliation>
<nlm:affiliation>Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Siracusano, A" sort="Siracusano, A" uniqKey="Siracusano A" first="A" last="Siracusano">A. Siracusano</name>
<affiliation>
<nlm:affiliation>Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Sperling, S" sort="Sperling, S" uniqKey="Sperling S" first="S" last="Sperling">S. Sperling</name>
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<nlm:affiliation>Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.</nlm:affiliation>
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<author>
<name sortKey="Rossner, M" sort="Rossner, M" uniqKey="Rossner M" first="M" last="Rossner">M. Rossner</name>
<affiliation>
<nlm:affiliation>1] DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany [2] Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Christiansen, C" sort="Christiansen, C" uniqKey="Christiansen C" first="C" last="Christiansen">C. Christiansen</name>
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<nlm:affiliation>Nordic Bioscience, Herlev, Denmark.</nlm:affiliation>
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<name sortKey="Kiemeney, L A" sort="Kiemeney, L A" uniqKey="Kiemeney L" first="L A" last="Kiemeney">L A Kiemeney</name>
<affiliation>
<nlm:affiliation>Department of Epidemiology and Biostatistics and Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Franke, B" sort="Franke, B" uniqKey="Franke B" first="B" last="Franke">B. Franke</name>
<affiliation>
<nlm:affiliation>Departments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
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<name sortKey="Van Den Berg, L H" sort="Van Den Berg, L H" uniqKey="Van Den Berg L" first="L H" last="Van Den Berg">L H Van Den Berg</name>
<affiliation>
<nlm:affiliation>Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Veldink, J" sort="Veldink, J" uniqKey="Veldink J" first="J" last="Veldink">J. Veldink</name>
<affiliation>
<nlm:affiliation>Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Curran, S" sort="Curran, S" uniqKey="Curran S" first="S" last="Curran">S. Curran</name>
<affiliation>
<nlm:affiliation>1] Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK [2] Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College, London UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Bolton, P" sort="Bolton, P" uniqKey="Bolton P" first="P" last="Bolton">P. Bolton</name>
<affiliation>
<nlm:affiliation>1] Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK [2] Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College, London UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Poot, M" sort="Poot, M" uniqKey="Poot M" first="M" last="Poot">M. Poot</name>
<affiliation>
<nlm:affiliation>Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Staal, W" sort="Staal, W" uniqKey="Staal W" first="W" last="Staal">W. Staal</name>
<affiliation>
<nlm:affiliation>Department of Cognitive Neuroscience, Radboud University Nijmegen, Nijmegen, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Rehnstrom, K" sort="Rehnstrom, K" uniqKey="Rehnstrom K" first="K" last="Rehnstrom">K. Rehnstrom</name>
<affiliation>
<nlm:affiliation>1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Wellcome Trust Sanger Institute, Cambridge, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Kilpinen, H" sort="Kilpinen, H" uniqKey="Kilpinen H" first="H" last="Kilpinen">H. Kilpinen</name>
<affiliation>
<nlm:affiliation>1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Wellcome Trust Sanger Institute, Cambridge, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Freitag, C M" sort="Freitag, C M" uniqKey="Freitag C" first="C M" last="Freitag">C M Freitag</name>
<affiliation>
<nlm:affiliation>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Frankfurt am Main, Frankfurt am Main, Germany.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Meyer, J" sort="Meyer, J" uniqKey="Meyer J" first="J" last="Meyer">J. Meyer</name>
<affiliation>
<nlm:affiliation>Department of Neurobehavioural Genetics, University of Trier, Trier, Germany.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Magnusson, P" sort="Magnusson, P" uniqKey="Magnusson P" first="P" last="Magnusson">P. Magnusson</name>
<affiliation>
<nlm:affiliation>Department of Child and Adolescent Psychiatry, National University Hospital, Reykjavik, Iceland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Saemundsen, E" sort="Saemundsen, E" uniqKey="Saemundsen E" first="E" last="Saemundsen">E. Saemundsen</name>
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<nlm:affiliation>State Diagnostic and Counseling Centre, Kopavogur, Iceland.</nlm:affiliation>
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<author>
<name sortKey="Martsenkovsky, I" sort="Martsenkovsky, I" uniqKey="Martsenkovsky I" first="I" last="Martsenkovsky">I. Martsenkovsky</name>
<affiliation>
<nlm:affiliation>Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Bikshaieva, I" sort="Bikshaieva, I" uniqKey="Bikshaieva I" first="I" last="Bikshaieva">I. Bikshaieva</name>
<affiliation>
<nlm:affiliation>Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Martsenkovska, I" sort="Martsenkovska, I" uniqKey="Martsenkovska I" first="I" last="Martsenkovska">I. Martsenkovska</name>
<affiliation>
<nlm:affiliation>Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Vashchenko, O" sort="Vashchenko, O" uniqKey="Vashchenko O" first="O" last="Vashchenko">O. Vashchenko</name>
<affiliation>
<nlm:affiliation>Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Raleva, M" sort="Raleva, M" uniqKey="Raleva M" first="M" last="Raleva">M. Raleva</name>
<affiliation>
<nlm:affiliation>Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Paketchieva, K" sort="Paketchieva, K" uniqKey="Paketchieva K" first="K" last="Paketchieva">K. Paketchieva</name>
<affiliation>
<nlm:affiliation>Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Stefanovski, B" sort="Stefanovski, B" uniqKey="Stefanovski B" first="B" last="Stefanovski">B. Stefanovski</name>
<affiliation>
<nlm:affiliation>Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Durmishi, N" sort="Durmishi, N" uniqKey="Durmishi N" first="N" last="Durmishi">N. Durmishi</name>
<affiliation>
<nlm:affiliation>Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Pejovic Milovancevic, M" sort="Pejovic Milovancevic, M" uniqKey="Pejovic Milovancevic M" first="M" last="Pejovic Milovancevic">M. Pejovic Milovancevic</name>
<affiliation>
<nlm:affiliation>1] Institute of Mental Health, Belgrade, Serbia [2] Medical Faculty, University of Belgrade, Belgrade, Serbia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Lecic Tosevski, D" sort="Lecic Tosevski, D" uniqKey="Lecic Tosevski D" first="D" last="Lecic Tosevski">D. Lecic Tosevski</name>
<affiliation>
<nlm:affiliation>1] Institute of Mental Health, Belgrade, Serbia [2] Medical Faculty, University of Belgrade, Belgrade, Serbia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Silagadze, T" sort="Silagadze, T" uniqKey="Silagadze T" first="T" last="Silagadze">T. Silagadze</name>
<affiliation>
<nlm:affiliation>Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Naneishvili, N" sort="Naneishvili, N" uniqKey="Naneishvili N" first="N" last="Naneishvili">N. Naneishvili</name>
<affiliation>
<nlm:affiliation>Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Mikeladze, N" sort="Mikeladze, N" uniqKey="Mikeladze N" first="N" last="Mikeladze">N. Mikeladze</name>
<affiliation>
<nlm:affiliation>Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Surguladze, S" sort="Surguladze, S" uniqKey="Surguladze S" first="S" last="Surguladze">S. Surguladze</name>
<affiliation>
<nlm:affiliation>Social and Affective Neuroscience Lab, Ilia State University, Tbilisi, Georgia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Vincent, J B" sort="Vincent, J B" uniqKey="Vincent J" first="J B" last="Vincent">J B Vincent</name>
<affiliation>
<nlm:affiliation>Molecular Neuropsychiatry and Development Laboratory, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Farmer, A" sort="Farmer, A" uniqKey="Farmer A" first="A" last="Farmer">A. Farmer</name>
<affiliation>
<nlm:affiliation>Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Mitchell, P B" sort="Mitchell, P B" uniqKey="Mitchell P" first="P B" last="Mitchell">P B Mitchell</name>
<affiliation>
<nlm:affiliation>1] Black Dog Institute, Prince of Wales Hospital, Randwick, NSW, Australia [2] School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Wright, A" sort="Wright, A" uniqKey="Wright A" first="A" last="Wright">A. Wright</name>
<affiliation>
<nlm:affiliation>1] Black Dog Institute, Prince of Wales Hospital, Randwick, NSW, Australia [2] School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Schofield, P R" sort="Schofield, P R" uniqKey="Schofield P" first="P R" last="Schofield">P R Schofield</name>
<affiliation>
<nlm:affiliation>1] Neuroscience Research Australia, Barker Street, Sydney, NSW, Australia [2] School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Fullerton, J M" sort="Fullerton, J M" uniqKey="Fullerton J" first="J M" last="Fullerton">J M Fullerton</name>
<affiliation>
<nlm:affiliation>1] Neuroscience Research Australia, Barker Street, Sydney, NSW, Australia [2] School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Montgomery, G W" sort="Montgomery, G W" uniqKey="Montgomery G" first="G W" last="Montgomery">G W Montgomery</name>
<affiliation>
<nlm:affiliation>Queensland Institute of Medical Research, Brisbane, QLD, Australia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Martin, N G" sort="Martin, N G" uniqKey="Martin N" first="N G" last="Martin">N G Martin</name>
<affiliation>
<nlm:affiliation>Queensland Institute of Medical Research, Brisbane, QLD, Australia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Rubino, I A" sort="Rubino, I A" uniqKey="Rubino I" first="I A" last="Rubino">I A Rubino</name>
<affiliation>
<nlm:affiliation>Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Van Winkel, R" sort="Van Winkel, R" uniqKey="Van Winkel R" first="R" last="Van Winkel">R. Van Winkel</name>
<affiliation>
<nlm:affiliation>1] University Psychiatric Center, Catholic University Leuven, Kortenberg, Belgium [2] Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience (EURON), South Limburg Mental Health Research and Teaching Network (SEARCH), Maastricht University Medical Center, Maastricht, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Kenis, G" sort="Kenis, G" uniqKey="Kenis G" first="G" last="Kenis">G. Kenis</name>
<affiliation>
<nlm:affiliation>Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience (EURON), South Limburg Mental Health Research and Teaching Network (SEARCH), Maastricht University Medical Center, Maastricht, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="De Hert, M" sort="De Hert, M" uniqKey="De Hert M" first="M" last="De Hert">M. De Hert</name>
<affiliation>
<nlm:affiliation>University Psychiatric Center, Catholic University Leuven, Kortenberg, Belgium.</nlm:affiliation>
</affiliation>
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<affiliation>
<nlm:affiliation>Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Bitter, I" sort="Bitter, I" uniqKey="Bitter I" first="I" last="Bitter">I. Bitter</name>
<affiliation>
<nlm:affiliation>Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Terenius, L" sort="Terenius, L" uniqKey="Terenius L" first="L" last="Terenius">L. Terenius</name>
<affiliation>
<nlm:affiliation>Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Jonsson, E G" sort="Jonsson, E G" uniqKey="Jonsson E" first="E G" last="Jönsson">E G Jönsson</name>
<affiliation>
<nlm:affiliation>Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Bakker, S" sort="Bakker, S" uniqKey="Bakker S" first="S" last="Bakker">S. Bakker</name>
<affiliation>
<nlm:affiliation>Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Van Os, J" sort="Van Os, J" uniqKey="Van Os J" first="J" last="Van Os">J. Van Os</name>
<affiliation>
<nlm:affiliation>Department of Psychiatry, Maastricht University Medical Centre, Maastricht, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Jablensky, A" sort="Jablensky, A" uniqKey="Jablensky A" first="A" last="Jablensky">A. Jablensky</name>
<affiliation>
<nlm:affiliation>Centre for Clinical Research in Neuropsychiatry (CCRN), Graylands Hospital, the University of Western Australia, Perth, WA, Australia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Leboyer, M" sort="Leboyer, M" uniqKey="Leboyer M" first="M" last="Leboyer">M. Leboyer</name>
<affiliation>
<nlm:affiliation>1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France [4] Université Paris Est, Faculté de Médecine, Creteil, France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Bramon, E" sort="Bramon, E" uniqKey="Bramon E" first="E" last="Bramon">E. Bramon</name>
<affiliation>
<nlm:affiliation>Mental Health Sciences Unit and Institute of Cognitive Neuroscience, University College London, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Powell, J" sort="Powell, J" uniqKey="Powell J" first="J" last="Powell">J. Powell</name>
<affiliation>
<nlm:affiliation>Department of Neuroscience, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King's College, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Murray, R" sort="Murray, R" uniqKey="Murray R" first="R" last="Murray">R. Murray</name>
<affiliation>
<nlm:affiliation>Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King's College, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Corvin, A" sort="Corvin, A" uniqKey="Corvin A" first="A" last="Corvin">A. Corvin</name>
<affiliation>
<nlm:affiliation>Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Gill, M" sort="Gill, M" uniqKey="Gill M" first="M" last="Gill">M. Gill</name>
<affiliation>
<nlm:affiliation>Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Morris, D" sort="Morris, D" uniqKey="Morris D" first="D" last="Morris">D. Morris</name>
<affiliation>
<nlm:affiliation>Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="O Neill, F A" sort="O Neill, F A" uniqKey="O Neill F" first="F A" last="O'Neill">F A O'Neill</name>
<affiliation>
<nlm:affiliation>Department of Psychiatry, Queens University, Belfast, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Kendler, K" sort="Kendler, K" uniqKey="Kendler K" first="K" last="Kendler">K. Kendler</name>
<affiliation>
<nlm:affiliation>1] Department of Human Genetics, Virginia Commonwealth University, Richmond, VA, USA [2] Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA [3] Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Riley, B" sort="Riley, B" uniqKey="Riley B" first="B" last="Riley">B. Riley</name>
<affiliation>
<nlm:affiliation>1] Department of Human Genetics, Virginia Commonwealth University, Richmond, VA, USA [2] Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA [3] Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Craddock, N" sort="Craddock, N" uniqKey="Craddock N" first="N" last="Craddock">N. Craddock</name>
<affiliation>
<nlm:affiliation>MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Owen, M J" sort="Owen, M J" uniqKey="Owen M" first="M J" last="Owen">M J Owen</name>
<affiliation>
<nlm:affiliation>MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="O Donovan, M C" sort="O Donovan, M C" uniqKey="O Donovan M" first="M C" last="O'Donovan">M C O'Donovan</name>
<affiliation>
<nlm:affiliation>MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.</nlm:affiliation>
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<nlm:affiliation>1] deCODE genetics, Reykjavik, Iceland [2] School of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:affiliation>
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</author>
<author>
<name sortKey="Kong, A" sort="Kong, A" uniqKey="Kong A" first="A" last="Kong">A. Kong</name>
<affiliation>
<nlm:affiliation>deCODE genetics, Reykjavik, Iceland.</nlm:affiliation>
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<affiliation>
<nlm:affiliation>1] DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany [2] Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.</nlm:affiliation>
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<nlm:affiliation>Genomic Medicine Group - Galician Foundation of Genomic Medicine-Biomedical Network Research Centre on Rare Diseases (CIBERER), University of Santiago de Compostela, Santiago de Compostela, Spain.</nlm:affiliation>
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<nlm:affiliation>Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia.</nlm:affiliation>
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<affiliation>
<nlm:affiliation>Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="B Rglum, A D" sort="B Rglum, A D" uniqKey="B Rglum A" first="A D" last="B Rglum">A D B Rglum</name>
<affiliation>
<nlm:affiliation>1] Department of Biomedicine, Human Genetics, and Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark [2] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [3] Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Mors, O" sort="Mors, O" uniqKey="Mors O" first="O" last="Mors">O. Mors</name>
<affiliation>
<nlm:affiliation>1] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [2] Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Mortensen, P B" sort="Mortensen, P B" uniqKey="Mortensen P" first="P B" last="Mortensen">P B Mortensen</name>
<affiliation>
<nlm:affiliation>1] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [2] National Centre for Register-based Research, Aarhus University, Aarhus, Denmark.</nlm:affiliation>
</affiliation>
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<name sortKey="Werge, T" sort="Werge, T" uniqKey="Werge T" first="T" last="Werge">T. Werge</name>
<affiliation>
<nlm:affiliation>1] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [2] Institute of Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University, Roskilde, Denmark.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Ophoff, R A" sort="Ophoff, R A" uniqKey="Ophoff R" first="R A" last="Ophoff">R A Ophoff</name>
<affiliation>
<nlm:affiliation>1] Center for Neurobehavioral Genetics, UCLA, Los Angeles, CA, USA [2] Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Nothen, M M" sort="Nothen, M M" uniqKey="Nothen M" first="M M" last="Nöthen">M M Nöthen</name>
<affiliation>
<nlm:affiliation>1] German Center for Neurodegenerative Disorders (DZNE), Bonn Germany [2] Institute of Human Genetics, University of Bonn, Bonn Germany.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Rietschel, M" sort="Rietschel, M" uniqKey="Rietschel M" first="M" last="Rietschel">M. Rietschel</name>
<affiliation>
<nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Cichon, S" sort="Cichon, S" uniqKey="Cichon S" first="S" last="Cichon">S. Cichon</name>
<affiliation>
<nlm:affiliation>1] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany [2] Institute of Human Genetics, University of Bonn, Bonn Germany [3] Institute of Neurosciences and Medicine (INM-1), Juelich, Germany.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Ruggeri, M" sort="Ruggeri, M" uniqKey="Ruggeri M" first="M" last="Ruggeri">M. Ruggeri</name>
<affiliation>
<nlm:affiliation>Section of Psychiatry, University of Verona, Verona, Italy.</nlm:affiliation>
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<author>
<name sortKey="Tosato, S" sort="Tosato, S" uniqKey="Tosato S" first="S" last="Tosato">S. Tosato</name>
<affiliation>
<nlm:affiliation>Section of Psychiatry, University of Verona, Verona, Italy.</nlm:affiliation>
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<name sortKey="Palotie, A" sort="Palotie, A" uniqKey="Palotie A" first="A" last="Palotie">A. Palotie</name>
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<nlm:affiliation>1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Wellcome Trust Sanger Institute, Cambridge, UK [3] Program in Medical and Population Genetics and Genetic Analysis Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA [4] Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland.</nlm:affiliation>
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<name sortKey="St Clair, D" sort="St Clair, D" uniqKey="St Clair D" first="D" last="St Clair">D. St Clair</name>
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<nlm:affiliation>Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen, UK.</nlm:affiliation>
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<name sortKey="Rujescu, D" sort="Rujescu, D" uniqKey="Rujescu D" first="D" last="Rujescu">D. Rujescu</name>
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<nlm:affiliation>1] Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany [2] Department of Psychiatry, University of Halle-Wittenberg, Halle, Germany.</nlm:affiliation>
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<name sortKey="Collier, D A" sort="Collier, D A" uniqKey="Collier D" first="D A" last="Collier">D A Collier</name>
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<nlm:affiliation>1] Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK [2] Eli Lilly and Co. Ltd, Erl Wood Manor, Windlesham, Surrey, UK.</nlm:affiliation>
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<name sortKey="Stefansson, H" sort="Stefansson, H" uniqKey="Stefansson H" first="H" last="Stefansson">H. Stefansson</name>
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<nlm:affiliation>deCODE genetics, Reykjavik, Iceland.</nlm:affiliation>
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<nlm:affiliation>1] deCODE genetics, Reykjavik, Iceland [2] School of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:affiliation>
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</analytic>
<series>
<title level="j">Molecular psychiatry</title>
<idno type="eISSN">1476-5578</idno>
<imprint>
<date when="2014" type="published">2014</date>
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<term>Bipolar Disorder (epidemiology)</term>
<term>Bipolar Disorder (genetics)</term>
<term>Chromosome Aberrations</term>
<term>Chromosomes, Human, Pair 16 (genetics)</term>
<term>Europe</term>
<term>Female</term>
<term>Gene Expression Profiling</term>
<term>Genetic Predisposition to Disease</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>International Cooperation</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Oligonucleotide Array Sequence Analysis</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Risk Factors</term>
<term>Schizophrenia (complications)</term>
<term>Schizophrenia (epidemiology)</term>
<term>Schizophrenia (genetics)</term>
<term>Young Adult</term>
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<term>Schizophrenia</term>
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<term>Bipolar Disorder</term>
<term>Schizophrenia</term>
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<term>Bipolar Disorder</term>
<term>Chromosomes, Human, Pair 16</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Schizophrenia</term>
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<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Chromosome Aberrations</term>
<term>Female</term>
<term>Gene Expression Profiling</term>
<term>Genetic Predisposition to Disease</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>International Cooperation</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
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<front>
<div type="abstract" xml:lang="en">Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18 206 cases and 42 536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46 160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T]; odds ratio=1.08; P=6.6 × 10(-11)). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22 651 additional Icelanders).</div>
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<PMID Version="1">23164818</PMID>
<DateCreated>
<Year>2013</Year>
<Month>12</Month>
<Day>23</Day>
</DateCreated>
<DateCompleted>
<Year>2014</Year>
<Month>08</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised>
<Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1476-5578</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>19</Volume>
<Issue>1</Issue>
<PubDate>
<Year>2014</Year>
<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>Molecular psychiatry</Title>
<ISOAbbreviation>Mol. Psychiatry</ISOAbbreviation>
</Journal>
<ArticleTitle>Common variant at 16p11.2 conferring risk of psychosis.</ArticleTitle>
<Pagination>
<MedlinePgn>108-14</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/mp.2012.157</ELocationID>
<Abstract>
<AbstractText>Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18 206 cases and 42 536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46 160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T]; odds ratio=1.08; P=6.6 × 10(-11)). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22 651 additional Icelanders).</AbstractText>
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