Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease.
Identifieur interne : 003961 ( PubMed/Corpus ); précédent : 003960; suivant : 003962Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease.
Auteurs : Helena Gylling ; Jogchum Plat ; Stephen Turley ; Henry N. Ginsberg ; Lars Elleg Rd ; Wendy Jessup ; Peter J. Jones ; Dieter Lütjohann ; Winfried Maerz ; Luis Masana ; Günther Silbernagel ; Bart Staels ; Jan Borén ; Alberico L. Catapano ; Guy De Backer ; John Deanfield ; Olivier S. Descamps ; Petri T. Kovanen ; Gabriele Riccardi ; Lale Tokgözoglu ; M John ChapmanSource :
- Atherosclerosis [ 1879-1484 ] ; 2014.
English descriptors
- KwdEn :
- Animals, Anticholesteremic Agents (therapeutic use), Cardiovascular Diseases (blood), Cardiovascular Diseases (prevention & control), Cardiovascular Diseases (therapy), Cholesterol (blood), Cholesterol (metabolism), Cholesterol, LDL (blood), Dyslipidemias (therapy), Humans, Inflammation (drug therapy), Lipids (blood), Phytosterols (therapeutic use), Sitosterols (therapeutic use), Triglycerides (blood).
- MESH :
- chemical , blood : Cholesterol, Cholesterol, LDL, Lipids, Triglycerides.
- chemical , metabolism : Cholesterol.
- chemical , therapeutic use : Anticholesteremic Agents, Phytosterols, Sitosterols.
- blood : Cardiovascular Diseases.
- drug therapy : Inflammation.
- prevention & control : Cardiovascular Diseases.
- therapy : Cardiovascular Diseases, Dyslipidemias.
- Animals, Humans.
Abstract
This EAS Consensus Panel critically appraised evidence relevant to the benefit to risk relationship of functional foods with added plant sterols and/or plant stanols, as components of a healthy lifestyle, to reduce plasma low-density lipoprotein-cholesterol (LDL-C) levels, and thereby lower cardiovascular risk.
DOI: 10.1016/j.atherosclerosis.2013.11.043
PubMed: 24468148
Links to Exploration step
pubmed:24468148Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease.</title><author><name sortKey="Gylling, Helena" sort="Gylling, Helena" uniqKey="Gylling H" first="Helena" last="Gylling">Helena Gylling</name><affiliation><nlm:affiliation>Department of Medicine, Division of Internal Medicine, University of Helsinki, Biomedicum Helsinki, Finland. Electronic address: Helena.Gylling@hus.fi.</nlm:affiliation></affiliation></author><author><name sortKey="Plat, Jogchum" sort="Plat, Jogchum" uniqKey="Plat J" first="Jogchum" last="Plat">Jogchum Plat</name><affiliation><nlm:affiliation>Department of Human Biology, Maastricht University, The Netherlands. Electronic address: j.plat@maastrichtuniversity.nl.</nlm:affiliation></affiliation></author><author><name sortKey="Turley, Stephen" sort="Turley, Stephen" uniqKey="Turley S" first="Stephen" last="Turley">Stephen Turley</name><affiliation><nlm:affiliation>Department of Internal Medicine, UT Southwestern Medical Center, Dallas, USA. Electronic address: Stephen.Turley@UTSouthwestern.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Ginsberg, Henry N" sort="Ginsberg, Henry N" uniqKey="Ginsberg H" first="Henry N" last="Ginsberg">Henry N. Ginsberg</name><affiliation><nlm:affiliation>Irving Institute for Clinical and Translational Research, Columbia University, New York, USA. Electronic address: hng1@columbia.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Elleg Rd, Lars" sort="Elleg Rd, Lars" uniqKey="Elleg Rd L" first="Lars" last="Elleg Rd">Lars Elleg Rd</name><affiliation><nlm:affiliation>Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy at University of Gothenburg, Sweden. Electronic address: lasse.ellegard@nutrition.gu.se.</nlm:affiliation></affiliation></author><author><name sortKey="Jessup, Wendy" sort="Jessup, Wendy" uniqKey="Jessup W" first="Wendy" last="Jessup">Wendy Jessup</name><affiliation><nlm:affiliation>ANZAC Research Institute, Concord Hospital, Sydney, Australia. Electronic address: wendy.jessup@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Jones, Peter J" sort="Jones, Peter J" uniqKey="Jones P" first="Peter J" last="Jones">Peter J. Jones</name><affiliation><nlm:affiliation>Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Canada. Electronic address: Peter.Jones@umanitoba.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Lutjohann, Dieter" sort="Lutjohann, Dieter" uniqKey="Lutjohann D" first="Dieter" last="Lütjohann">Dieter Lütjohann</name><affiliation><nlm:affiliation>Institute of Clinical Chemistry and Clinical Pharmacology, University Clinics Bonn, Germany. Electronic address: Dieter.Luetjohann@ukb.uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Maerz, Winfried" sort="Maerz, Winfried" uniqKey="Maerz W" first="Winfried" last="Maerz">Winfried Maerz</name><affiliation><nlm:affiliation>Synlab Academy, Synlab LLC, Mannheim Center of Laboratory Diagnostics, Heidelberg, Germany; Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, University of Heidelberg, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria. Electronic address: Winfried.Maerz@synlab.com.</nlm:affiliation></affiliation></author><author><name sortKey="Masana, Luis" sort="Masana, Luis" uniqKey="Masana L" first="Luis" last="Masana">Luis Masana</name><affiliation><nlm:affiliation>Vascular Medicine and Metabolism Unit, University Hospital Sant Joan, IISPV, CIBERDEM, Rovira and Virgili University, Reus, Spain. Electronic address: luis.masana@urv.cat.</nlm:affiliation></affiliation></author><author><name sortKey="Silbernagel, Gunther" sort="Silbernagel, Gunther" uniqKey="Silbernagel G" first="Günther" last="Silbernagel">Günther Silbernagel</name><affiliation><nlm:affiliation>Department of Angiology, Swiss Cardiovascular Center, Inselspital, University of Bern, Switzerland. Electronic address: guenther.silbernagel@yahoo.com.</nlm:affiliation></affiliation></author><author><name sortKey="Staels, Bart" sort="Staels, Bart" uniqKey="Staels B" first="Bart" last="Staels">Bart Staels</name><affiliation><nlm:affiliation>Faculty of Pharmacy, University of Lille 2, Lille, France. Electronic address: Bart.Staels@pasteur-lille.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Boren, Jan" sort="Boren, Jan" uniqKey="Boren J" first="Jan" last="Borén">Jan Borén</name><affiliation><nlm:affiliation>Strategic Research Center, Sahlgrenska Center for Cardiovascular and Metabolic Research (CMR), University of Gothenburg, Sweden. Electronic address: Jan.Boren@wlab.gu.se.</nlm:affiliation></affiliation></author><author><name sortKey="Catapano, Alberico L" sort="Catapano, Alberico L" uniqKey="Catapano A" first="Alberico L" last="Catapano">Alberico L. Catapano</name><affiliation><nlm:affiliation>Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy; Multimedica IRCSS Milano, Italy. Electronic address: alberico.catapano@unimi.it.</nlm:affiliation></affiliation></author><author><name sortKey="De Backer, Guy" sort="De Backer, Guy" uniqKey="De Backer G" first="Guy" last="De Backer">Guy De Backer</name><affiliation><nlm:affiliation>Department of Public Health, University Hospital Ghent, Ghent, Belgium. Electronic address: guy.debacker@ugent.be.</nlm:affiliation></affiliation></author><author><name sortKey="Deanfield, John" sort="Deanfield, John" uniqKey="Deanfield J" first="John" last="Deanfield">John Deanfield</name><affiliation><nlm:affiliation>National Centre for Cardiovascular Prevention and Outcomes, University College London, UK. Electronic address: john.deanfield@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Descamps, Olivier S" sort="Descamps, Olivier S" uniqKey="Descamps O" first="Olivier S" last="Descamps">Olivier S. Descamps</name><affiliation><nlm:affiliation>Lipid Clinic, Hopital de Jolimont, Haine-Saint-Paul, Belgium. Electronic address: olivierdescamps@hotmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Kovanen, Petri T" sort="Kovanen, Petri T" uniqKey="Kovanen P" first="Petri T" last="Kovanen">Petri T. Kovanen</name><affiliation><nlm:affiliation>Wihuri Research Institute, Helsinki, Finland. Electronic address: Petri.Kovanen@wri.fi.</nlm:affiliation></affiliation></author><author><name sortKey="Riccardi, Gabriele" sort="Riccardi, Gabriele" uniqKey="Riccardi G" first="Gabriele" last="Riccardi">Gabriele Riccardi</name><affiliation><nlm:affiliation>Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. Electronic address: riccardi@unina.it.</nlm:affiliation></affiliation></author><author><name sortKey="Tokgozoglu, Lale" sort="Tokgozoglu, Lale" uniqKey="Tokgozoglu L" first="Lale" last="Tokgözoglu">Lale Tokgözoglu</name><affiliation><nlm:affiliation>Department of Cardiology, Hacettepe University, Ankara, Turkey. Electronic address: lalet@hacettepe.edu.tr.</nlm:affiliation></affiliation></author><author><name sortKey="Chapman, M John" sort="Chapman, M John" uniqKey="Chapman M" first="M John" last="Chapman">M John Chapman</name><affiliation><nlm:affiliation>University of Pierre and Marie Curie, Paris, France; Dyslipidaemia and Atherosclerosis Research Unit, INSERM U939, Pitié-Salpetriere University Hospital, Paris, France. Electronic address: john.chapman@upmc.fr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24468148</idno><idno type="pmid">24468148</idno><idno type="doi">10.1016/j.atherosclerosis.2013.11.043</idno><idno type="wicri:Area/PubMed/Corpus">003961</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003961</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease.</title><author><name sortKey="Gylling, Helena" sort="Gylling, Helena" uniqKey="Gylling H" first="Helena" last="Gylling">Helena Gylling</name><affiliation><nlm:affiliation>Department of Medicine, Division of Internal Medicine, University of Helsinki, Biomedicum Helsinki, Finland. Electronic address: Helena.Gylling@hus.fi.</nlm:affiliation></affiliation></author><author><name sortKey="Plat, Jogchum" sort="Plat, Jogchum" uniqKey="Plat J" first="Jogchum" last="Plat">Jogchum Plat</name><affiliation><nlm:affiliation>Department of Human Biology, Maastricht University, The Netherlands. Electronic address: j.plat@maastrichtuniversity.nl.</nlm:affiliation></affiliation></author><author><name sortKey="Turley, Stephen" sort="Turley, Stephen" uniqKey="Turley S" first="Stephen" last="Turley">Stephen Turley</name><affiliation><nlm:affiliation>Department of Internal Medicine, UT Southwestern Medical Center, Dallas, USA. Electronic address: Stephen.Turley@UTSouthwestern.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Ginsberg, Henry N" sort="Ginsberg, Henry N" uniqKey="Ginsberg H" first="Henry N" last="Ginsberg">Henry N. Ginsberg</name><affiliation><nlm:affiliation>Irving Institute for Clinical and Translational Research, Columbia University, New York, USA. Electronic address: hng1@columbia.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Elleg Rd, Lars" sort="Elleg Rd, Lars" uniqKey="Elleg Rd L" first="Lars" last="Elleg Rd">Lars Elleg Rd</name><affiliation><nlm:affiliation>Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy at University of Gothenburg, Sweden. Electronic address: lasse.ellegard@nutrition.gu.se.</nlm:affiliation></affiliation></author><author><name sortKey="Jessup, Wendy" sort="Jessup, Wendy" uniqKey="Jessup W" first="Wendy" last="Jessup">Wendy Jessup</name><affiliation><nlm:affiliation>ANZAC Research Institute, Concord Hospital, Sydney, Australia. Electronic address: wendy.jessup@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Jones, Peter J" sort="Jones, Peter J" uniqKey="Jones P" first="Peter J" last="Jones">Peter J. Jones</name><affiliation><nlm:affiliation>Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Canada. Electronic address: Peter.Jones@umanitoba.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Lutjohann, Dieter" sort="Lutjohann, Dieter" uniqKey="Lutjohann D" first="Dieter" last="Lütjohann">Dieter Lütjohann</name><affiliation><nlm:affiliation>Institute of Clinical Chemistry and Clinical Pharmacology, University Clinics Bonn, Germany. Electronic address: Dieter.Luetjohann@ukb.uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Maerz, Winfried" sort="Maerz, Winfried" uniqKey="Maerz W" first="Winfried" last="Maerz">Winfried Maerz</name><affiliation><nlm:affiliation>Synlab Academy, Synlab LLC, Mannheim Center of Laboratory Diagnostics, Heidelberg, Germany; Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, University of Heidelberg, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria. Electronic address: Winfried.Maerz@synlab.com.</nlm:affiliation></affiliation></author><author><name sortKey="Masana, Luis" sort="Masana, Luis" uniqKey="Masana L" first="Luis" last="Masana">Luis Masana</name><affiliation><nlm:affiliation>Vascular Medicine and Metabolism Unit, University Hospital Sant Joan, IISPV, CIBERDEM, Rovira and Virgili University, Reus, Spain. Electronic address: luis.masana@urv.cat.</nlm:affiliation></affiliation></author><author><name sortKey="Silbernagel, Gunther" sort="Silbernagel, Gunther" uniqKey="Silbernagel G" first="Günther" last="Silbernagel">Günther Silbernagel</name><affiliation><nlm:affiliation>Department of Angiology, Swiss Cardiovascular Center, Inselspital, University of Bern, Switzerland. Electronic address: guenther.silbernagel@yahoo.com.</nlm:affiliation></affiliation></author><author><name sortKey="Staels, Bart" sort="Staels, Bart" uniqKey="Staels B" first="Bart" last="Staels">Bart Staels</name><affiliation><nlm:affiliation>Faculty of Pharmacy, University of Lille 2, Lille, France. Electronic address: Bart.Staels@pasteur-lille.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Boren, Jan" sort="Boren, Jan" uniqKey="Boren J" first="Jan" last="Borén">Jan Borén</name><affiliation><nlm:affiliation>Strategic Research Center, Sahlgrenska Center for Cardiovascular and Metabolic Research (CMR), University of Gothenburg, Sweden. Electronic address: Jan.Boren@wlab.gu.se.</nlm:affiliation></affiliation></author><author><name sortKey="Catapano, Alberico L" sort="Catapano, Alberico L" uniqKey="Catapano A" first="Alberico L" last="Catapano">Alberico L. Catapano</name><affiliation><nlm:affiliation>Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy; Multimedica IRCSS Milano, Italy. Electronic address: alberico.catapano@unimi.it.</nlm:affiliation></affiliation></author><author><name sortKey="De Backer, Guy" sort="De Backer, Guy" uniqKey="De Backer G" first="Guy" last="De Backer">Guy De Backer</name><affiliation><nlm:affiliation>Department of Public Health, University Hospital Ghent, Ghent, Belgium. Electronic address: guy.debacker@ugent.be.</nlm:affiliation></affiliation></author><author><name sortKey="Deanfield, John" sort="Deanfield, John" uniqKey="Deanfield J" first="John" last="Deanfield">John Deanfield</name><affiliation><nlm:affiliation>National Centre for Cardiovascular Prevention and Outcomes, University College London, UK. Electronic address: john.deanfield@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Descamps, Olivier S" sort="Descamps, Olivier S" uniqKey="Descamps O" first="Olivier S" last="Descamps">Olivier S. Descamps</name><affiliation><nlm:affiliation>Lipid Clinic, Hopital de Jolimont, Haine-Saint-Paul, Belgium. Electronic address: olivierdescamps@hotmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Kovanen, Petri T" sort="Kovanen, Petri T" uniqKey="Kovanen P" first="Petri T" last="Kovanen">Petri T. Kovanen</name><affiliation><nlm:affiliation>Wihuri Research Institute, Helsinki, Finland. Electronic address: Petri.Kovanen@wri.fi.</nlm:affiliation></affiliation></author><author><name sortKey="Riccardi, Gabriele" sort="Riccardi, Gabriele" uniqKey="Riccardi G" first="Gabriele" last="Riccardi">Gabriele Riccardi</name><affiliation><nlm:affiliation>Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. Electronic address: riccardi@unina.it.</nlm:affiliation></affiliation></author><author><name sortKey="Tokgozoglu, Lale" sort="Tokgozoglu, Lale" uniqKey="Tokgozoglu L" first="Lale" last="Tokgözoglu">Lale Tokgözoglu</name><affiliation><nlm:affiliation>Department of Cardiology, Hacettepe University, Ankara, Turkey. Electronic address: lalet@hacettepe.edu.tr.</nlm:affiliation></affiliation></author><author><name sortKey="Chapman, M John" sort="Chapman, M John" uniqKey="Chapman M" first="M John" last="Chapman">M John Chapman</name><affiliation><nlm:affiliation>University of Pierre and Marie Curie, Paris, France; Dyslipidaemia and Atherosclerosis Research Unit, INSERM U939, Pitié-Salpetriere University Hospital, Paris, France. Electronic address: john.chapman@upmc.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Atherosclerosis</title><idno type="eISSN">1879-1484</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anticholesteremic Agents (therapeutic use)</term><term>Cardiovascular Diseases (blood)</term><term>Cardiovascular Diseases (prevention & control)</term><term>Cardiovascular Diseases (therapy)</term><term>Cholesterol (blood)</term><term>Cholesterol (metabolism)</term><term>Cholesterol, LDL (blood)</term><term>Dyslipidemias (therapy)</term><term>Humans</term><term>Inflammation (drug therapy)</term><term>Lipids (blood)</term><term>Phytosterols (therapeutic use)</term><term>Sitosterols (therapeutic use)</term><term>Triglycerides (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cholesterol</term><term>Cholesterol, LDL</term><term>Lipids</term><term>Triglycerides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cholesterol</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anticholesteremic Agents</term><term>Phytosterols</term><term>Sitosterols</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Cardiovascular Diseases</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Cardiovascular Diseases</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Cardiovascular Diseases</term><term>Dyslipidemias</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This EAS Consensus Panel critically appraised evidence relevant to the benefit to risk relationship of functional foods with added plant sterols and/or plant stanols, as components of a healthy lifestyle, to reduce plasma low-density lipoprotein-cholesterol (LDL-C) levels, and thereby lower cardiovascular risk.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24468148</PMID><DateCreated><Year>2014</Year><Month>01</Month><Day>28</Day></DateCreated><DateCompleted><Year>2014</Year><Month>09</Month><Day>29</Day></DateCompleted><DateRevised><Year>2014</Year><Month>01</Month><Day>28</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1484</ISSN><JournalIssue CitedMedium="Internet"><Volume>232</Volume><Issue>2</Issue><PubDate><Year>2014</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Atherosclerosis</Title><ISOAbbreviation>Atherosclerosis</ISOAbbreviation></Journal><ArticleTitle>Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease.</ArticleTitle><Pagination><MedlinePgn>346-60</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.atherosclerosis.2013.11.043</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0021-9150(13)00694-1</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">This EAS Consensus Panel critically appraised evidence relevant to the benefit to risk relationship of functional foods with added plant sterols and/or plant stanols, as components of a healthy lifestyle, to reduce plasma low-density lipoprotein-cholesterol (LDL-C) levels, and thereby lower cardiovascular risk.</AbstractText><AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">Plant sterols/stanols (when taken at 2 g/day) cause significant inhibition of cholesterol absorption and lower LDL-C levels by between 8 and 10%. The relative proportions of cholesterol versus sterol/stanol levels are similar in both plasma and tissue, with levels of sterols/stanols being 500-/10,000-fold lower than those of cholesterol, suggesting they are handled similarly to cholesterol in most cells. Despite possible atherogenicity of marked elevations in circulating levels of plant sterols/stanols, protective effects have been observed in some animal models of atherosclerosis. Higher plasma levels of plant sterols/stanols associated with intakes of 2 g/day in man have not been linked to adverse effects on health in long-term human studies. Importantly, at this dose, plant sterol/stanol-mediated LDL-C lowering is additive to that of statins in dyslipidaemic subjects, equivalent to doubling the dose of statin. The reported 6-9% lowering of plasma triglyceride by 2 g/day in hypertriglyceridaemic patients warrants further evaluation.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Based on LDL-C lowering and the absence of adverse signals, this EAS Consensus Panel concludes that functional foods with plant sterols/stanols may be considered 1) in individuals with high cholesterol levels at intermediate or low global cardiovascular risk who do not qualify for pharmacotherapy, 2) as an adjunct to pharmacologic therapy in high and very high risk patients who fail to achieve LDL-C targets on statins or are statin- intolerant, 3) and in adults and children (>6 years) with familial hypercholesterolaemia, in line with current guidance. However, it must be acknowledged that there are no randomised, controlled clinical trial data with hard end-points to establish clinical benefit from the use of plant sterols or plant stanols.</AbstractText><CopyrightInformation>Copyright © 2013 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gylling</LastName><ForeName>Helena</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Internal Medicine, University of Helsinki, Biomedicum Helsinki, Finland. Electronic address: Helena.Gylling@hus.fi.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Plat</LastName><ForeName>Jogchum</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Human Biology, Maastricht University, The Netherlands. Electronic address: j.plat@maastrichtuniversity.nl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Turley</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, UT Southwestern Medical Center, Dallas, USA. Electronic address: Stephen.Turley@UTSouthwestern.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ginsberg</LastName><ForeName>Henry N</ForeName><Initials>HN</Initials><AffiliationInfo><Affiliation>Irving Institute for Clinical and Translational Research, Columbia University, New York, USA. Electronic address: hng1@columbia.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ellegård</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy at University of Gothenburg, Sweden. Electronic address: lasse.ellegard@nutrition.gu.se.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jessup</LastName><ForeName>Wendy</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>ANZAC Research Institute, Concord Hospital, Sydney, Australia. Electronic address: wendy.jessup@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jones</LastName><ForeName>Peter J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Canada. Electronic address: Peter.Jones@umanitoba.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lütjohann</LastName><ForeName>Dieter</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institute of Clinical Chemistry and Clinical Pharmacology, University Clinics Bonn, Germany. Electronic address: Dieter.Luetjohann@ukb.uni-bonn.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maerz</LastName><ForeName>Winfried</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Synlab Academy, Synlab LLC, Mannheim Center of Laboratory Diagnostics, Heidelberg, Germany; Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, University of Heidelberg, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria. Electronic address: Winfried.Maerz@synlab.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Masana</LastName><ForeName>Luis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Vascular Medicine and Metabolism Unit, University Hospital Sant Joan, IISPV, CIBERDEM, Rovira and Virgili University, Reus, Spain. Electronic address: luis.masana@urv.cat.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silbernagel</LastName><ForeName>Günther</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Angiology, Swiss Cardiovascular Center, Inselspital, University of Bern, Switzerland. Electronic address: guenther.silbernagel@yahoo.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Staels</LastName><ForeName>Bart</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Faculty of Pharmacy, University of Lille 2, Lille, France. Electronic address: Bart.Staels@pasteur-lille.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borén</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Strategic Research Center, Sahlgrenska Center for Cardiovascular and Metabolic Research (CMR), University of Gothenburg, Sweden. Electronic address: Jan.Boren@wlab.gu.se.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Catapano</LastName><ForeName>Alberico L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy; Multimedica IRCSS Milano, Italy. Electronic address: alberico.catapano@unimi.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Backer</LastName><ForeName>Guy</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Public Health, University Hospital Ghent, Ghent, Belgium. Electronic address: guy.debacker@ugent.be.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deanfield</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>National Centre for Cardiovascular Prevention and Outcomes, University College London, UK. Electronic address: john.deanfield@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Descamps</LastName><ForeName>Olivier S</ForeName><Initials>OS</Initials><AffiliationInfo><Affiliation>Lipid Clinic, Hopital de Jolimont, Haine-Saint-Paul, Belgium. Electronic address: olivierdescamps@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kovanen</LastName><ForeName>Petri T</ForeName><Initials>PT</Initials><AffiliationInfo><Affiliation>Wihuri Research Institute, Helsinki, Finland. Electronic address: Petri.Kovanen@wri.fi.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riccardi</LastName><ForeName>Gabriele</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. Electronic address: riccardi@unina.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tokgözoglu</LastName><ForeName>Lale</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Hacettepe University, Ankara, Turkey. Electronic address: lalet@hacettepe.edu.tr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chapman</LastName><ForeName>M John</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>University of Pierre and Marie Curie, Paris, France; Dyslipidaemia and Atherosclerosis Research Unit, INSERM U939, Pitié-Salpetriere University Hospital, Paris, France. Electronic address: john.chapman@upmc.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>European Atherosclerosis Society Consensus Panel on Phytosterols</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01HL09610</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>11</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>Atherosclerosis</MedlineTA><NlmUniqueID>0242543</NlmUniqueID><ISSNLinking>0021-9150</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000924">Anticholesteremic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008078">Cholesterol, LDL</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008055">Lipids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010840">Phytosterols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012855">Sitosterols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014280">Triglycerides</NameOfSubstance></Chemical><Chemical><RegistryNumber>97C5T2UQ7J</RegistryNumber><NameOfSubstance UI="D002784">Cholesterol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Atherosclerosis. 2014 Apr;233(2):357-8</RefSource><PMID Version="1">24530762</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000924" MajorTopicYN="N">Anticholesteremic Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002318" MajorTopicYN="N">Cardiovascular Diseases</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002784" MajorTopicYN="N">Cholesterol</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008078" MajorTopicYN="N">Cholesterol, LDL</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050171" MajorTopicYN="N">Dyslipidemias</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008055" MajorTopicYN="N">Lipids</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010840" MajorTopicYN="N">Phytosterols</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012855" MajorTopicYN="N">Sitosterols</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014280" MajorTopicYN="N">Triglycerides</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cardiovascular risk</Keyword><Keyword MajorTopicYN="N">Functional foods with added plant sterols and plant stanols</Keyword><Keyword MajorTopicYN="N">Hypercholesterolaemia</Keyword><Keyword MajorTopicYN="N">Intestinal cholesterol absorption</Keyword><Keyword MajorTopicYN="N">Phytosterols</Keyword><Keyword MajorTopicYN="N">Safety</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>11</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>11</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>1</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>1</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>9</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24468148</ArticleId><ArticleId IdType="pii">S0021-9150(13)00694-1</ArticleId><ArticleId IdType="doi">10.1016/j.atherosclerosis.2013.11.043</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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