Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.
Identifieur interne : 003703 ( PubMed/Corpus ); précédent : 003702; suivant : 003704Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.
Auteurs : Petter S. Woll ; Una Kj Llquist ; Onima Chowdhury ; Helen Doolittle ; David C. Wedge ; Supat Thongjuea ; Rikard Erlandsson ; Mtakai Ngara ; Kristina Anderson ; Qiaolin Deng ; Adam J. Mead ; Laura Stenson ; Alice Giustacchini ; Sara Duarte ; Eleni Giannoulatou ; Stephen Taylor ; Mohsen Karimi ; Christian Scharenberg ; Teresa Mortera-Blanco ; Iain C. Macaulay ; Sally-Ann Clark ; Ingunn Dybedal ; Dag Josefsen ; Pierre Fenaux ; Peter Hokland ; Mette S. Holm ; Mario Cazzola ; Luca Malcovati ; Sudhir Tauro ; David Bowen ; Jacqueline Boultwood ; Andrea Pellagatti ; John E. Pimanda ; Ashwin Unnikrishnan ; Paresh Vyas ; Gudrun Göhring ; Brigitte Schlegelberger ; Magnus Tobiasson ; Gunnar Kvalheim ; Stefan N. Constantinescu ; Claus Nerlov ; Lars Nilsson ; Peter J. Campbell ; Rickard Sandberg ; Elli Papaemmanuil ; Eva Hellström-Lindberg ; Sten Linnarsson ; Sten Eirik W. JacobsenSource :
- Cancer cell [ 1878-3686 ] ; 2014.
English descriptors
- KwdEn :
- Animals, Antigens, CD (biosynthesis), Antigens, CD (immunology), Chromosome Deletion, Chromosomes, Human, Pair 5, Flow Cytometry, Gene Expression Profiling, Genetic Predisposition to Disease, Heterografts, Humans, Mice, Mice, Inbred NOD, Mutation, Myelodysplastic Syndromes (genetics), Myelodysplastic Syndromes (immunology), Myelodysplastic Syndromes (pathology), Neoplastic Stem Cells (immunology), Neoplastic Stem Cells (pathology), Neoplastic Stem Cells (physiology), Prognosis.
- MESH :
- chemical , biosynthesis : Antigens, CD.
- chemical , immunology : Antigens, CD.
- genetics : Myelodysplastic Syndromes.
- immunology : Myelodysplastic Syndromes, Neoplastic Stem Cells.
- pathology : Myelodysplastic Syndromes, Neoplastic Stem Cells.
- physiology : Neoplastic Stem Cells.
- Animals, Chromosome Deletion, Chromosomes, Human, Pair 5, Flow Cytometry, Gene Expression Profiling, Genetic Predisposition to Disease, Heterografts, Humans, Mice, Mice, Inbred NOD, Mutation, Prognosis.
Abstract
Evidence for distinct human cancer stem cells (CSCs) remains contentious and the degree to which different cancer cells contribute to propagating malignancies in patients remains unexplored. In low- to intermediate-risk myelodysplastic syndromes (MDS), we establish the existence of rare multipotent MDS stem cells (MDS-SCs), and their hierarchical relationship to lineage-restricted MDS progenitors. All identified somatically acquired genetic lesions were backtracked to distinct MDS-SCs, establishing their distinct MDS-propagating function in vivo. In isolated del(5q)-MDS, acquisition of del(5q) preceded diverse recurrent driver mutations. Sequential analysis in del(5q)-MDS revealed genetic evolution in MDS-SCs and MDS-progenitors prior to leukemic transformation. These findings provide definitive evidence for rare human MDS-SCs in vivo, with extensive implications for the targeting of the cells required and sufficient for MDS-propagation.
DOI: 10.1016/j.ccr.2014.03.036
PubMed: 24835589
Links to Exploration step
pubmed:24835589Le document en format XML
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Woll</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kj Llquist, Una" sort="Kj Llquist, Una" uniqKey="Kj Llquist U" first="Una" last="Kj Llquist">Una Kj Llquist</name><affiliation><nlm:affiliation>Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 65 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Chowdhury, Onima" sort="Chowdhury, Onima" uniqKey="Chowdhury O" first="Onima" last="Chowdhury">Onima Chowdhury</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Doolittle, Helen" sort="Doolittle, Helen" uniqKey="Doolittle H" first="Helen" last="Doolittle">Helen Doolittle</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wedge, David C" sort="Wedge, David C" uniqKey="Wedge D" first="David C" last="Wedge">David C. Wedge</name><affiliation><nlm:affiliation>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Thongjuea, Supat" sort="Thongjuea, Supat" uniqKey="Thongjuea S" first="Supat" last="Thongjuea">Supat Thongjuea</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Erlandsson, Rikard" sort="Erlandsson, Rikard" uniqKey="Erlandsson R" first="Rikard" last="Erlandsson">Rikard Erlandsson</name><affiliation><nlm:affiliation>Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 65 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Ngara, Mtakai" sort="Ngara, Mtakai" uniqKey="Ngara M" first="Mtakai" last="Ngara">Mtakai Ngara</name><affiliation><nlm:affiliation>Ludwig Institute for Cancer Research and Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Anderson, Kristina" sort="Anderson, Kristina" uniqKey="Anderson K" first="Kristina" last="Anderson">Kristina Anderson</name><affiliation><nlm:affiliation>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Deng, Qiaolin" sort="Deng, Qiaolin" uniqKey="Deng Q" first="Qiaolin" last="Deng">Qiaolin Deng</name><affiliation><nlm:affiliation>Ludwig Institute for Cancer Research and Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Mead, Adam J" sort="Mead, Adam J" uniqKey="Mead A" first="Adam J" last="Mead">Adam J. Mead</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Stenson, Laura" sort="Stenson, Laura" uniqKey="Stenson L" first="Laura" last="Stenson">Laura Stenson</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Giustacchini, Alice" sort="Giustacchini, Alice" uniqKey="Giustacchini A" first="Alice" last="Giustacchini">Alice Giustacchini</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Duarte, Sara" sort="Duarte, Sara" uniqKey="Duarte S" first="Sara" last="Duarte">Sara Duarte</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Giannoulatou, Eleni" sort="Giannoulatou, Eleni" uniqKey="Giannoulatou E" first="Eleni" last="Giannoulatou">Eleni Giannoulatou</name><affiliation><nlm:affiliation>Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Taylor, Stephen" sort="Taylor, Stephen" uniqKey="Taylor S" first="Stephen" last="Taylor">Stephen Taylor</name><affiliation><nlm:affiliation>Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Karimi, Mohsen" sort="Karimi, Mohsen" uniqKey="Karimi M" first="Mohsen" last="Karimi">Mohsen Karimi</name><affiliation><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Scharenberg, Christian" sort="Scharenberg, Christian" uniqKey="Scharenberg C" first="Christian" last="Scharenberg">Christian Scharenberg</name><affiliation><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Mortera Blanco, Teresa" sort="Mortera Blanco, Teresa" uniqKey="Mortera Blanco T" first="Teresa" last="Mortera-Blanco">Teresa Mortera-Blanco</name><affiliation><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Macaulay, Iain C" sort="Macaulay, Iain C" uniqKey="Macaulay I" first="Iain C" last="Macaulay">Iain C. Macaulay</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Clark, Sally Ann" sort="Clark, Sally Ann" uniqKey="Clark S" first="Sally-Ann" last="Clark">Sally-Ann Clark</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Dybedal, Ingunn" sort="Dybedal, Ingunn" uniqKey="Dybedal I" first="Ingunn" last="Dybedal">Ingunn Dybedal</name><affiliation><nlm:affiliation>Department of Hematology, Oslo University Hospital, Rikshospitalet, 0130 Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Josefsen, Dag" sort="Josefsen, Dag" uniqKey="Josefsen D" first="Dag" last="Josefsen">Dag Josefsen</name><affiliation><nlm:affiliation>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Fenaux, Pierre" sort="Fenaux, Pierre" uniqKey="Fenaux P" first="Pierre" last="Fenaux">Pierre Fenaux</name><affiliation><nlm:affiliation>Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris (AP-HP), Service d'hématologie clinique, 93000 Bobigny, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hokland, Peter" sort="Hokland, Peter" uniqKey="Hokland P" first="Peter" last="Hokland">Peter Hokland</name><affiliation><nlm:affiliation>Department of Hematology, Aarhus University Hospital, 8000 Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Holm, Mette S" sort="Holm, Mette S" uniqKey="Holm M" first="Mette S" last="Holm">Mette S. Holm</name><affiliation><nlm:affiliation>Department of Hematology, Aarhus University Hospital, 8000 Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Cazzola, Mario" sort="Cazzola, Mario" uniqKey="Cazzola M" first="Mario" last="Cazzola">Mario Cazzola</name><affiliation><nlm:affiliation>Department of Molecular Medicine, University of Pavia, and Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Malcovati, Luca" sort="Malcovati, Luca" uniqKey="Malcovati L" first="Luca" last="Malcovati">Luca Malcovati</name><affiliation><nlm:affiliation>Department of Molecular Medicine, University of Pavia, and Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tauro, Sudhir" sort="Tauro, Sudhir" uniqKey="Tauro S" first="Sudhir" last="Tauro">Sudhir Tauro</name><affiliation><nlm:affiliation>Division of Medical Sciences, University of Dundee, Dundee DD1 9SY, Scotland, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bowen, David" sort="Bowen, David" uniqKey="Bowen D" first="David" last="Bowen">David Bowen</name><affiliation><nlm:affiliation>St. James Institute of Oncology, St. James Hospital, Leeds LS9 7TF, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Boultwood, Jacqueline" sort="Boultwood, Jacqueline" uniqKey="Boultwood J" first="Jacqueline" last="Boultwood">Jacqueline Boultwood</name><affiliation><nlm:affiliation>Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Pellagatti, Andrea" sort="Pellagatti, Andrea" uniqKey="Pellagatti A" first="Andrea" last="Pellagatti">Andrea Pellagatti</name><affiliation><nlm:affiliation>Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Pimanda, John E" sort="Pimanda, John E" uniqKey="Pimanda J" first="John E" last="Pimanda">John E. Pimanda</name><affiliation><nlm:affiliation>Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney 2052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Unnikrishnan, Ashwin" sort="Unnikrishnan, Ashwin" uniqKey="Unnikrishnan A" first="Ashwin" last="Unnikrishnan">Ashwin Unnikrishnan</name><affiliation><nlm:affiliation>Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney 2052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Vyas, Paresh" sort="Vyas, Paresh" uniqKey="Vyas P" first="Paresh" last="Vyas">Paresh Vyas</name><affiliation><nlm:affiliation>MRC Molecular Haematology Unit, Department of Haematology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Oxford University Hospital, NHS Trust, Oxford OX3 9DU, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Gohring, Gudrun" sort="Gohring, Gudrun" uniqKey="Gohring G" first="Gudrun" last="Göhring">Gudrun Göhring</name><affiliation><nlm:affiliation>Institute of Cell and Molecular Pathology, Hannover Medical School, 30625 Hannover, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schlegelberger, Brigitte" sort="Schlegelberger, Brigitte" uniqKey="Schlegelberger B" first="Brigitte" last="Schlegelberger">Brigitte Schlegelberger</name><affiliation><nlm:affiliation>Institute of Cell and Molecular Pathology, Hannover Medical School, 30625 Hannover, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Tobiasson, Magnus" sort="Tobiasson, Magnus" uniqKey="Tobiasson M" first="Magnus" last="Tobiasson">Magnus Tobiasson</name><affiliation><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Kvalheim, Gunnar" sort="Kvalheim, Gunnar" uniqKey="Kvalheim G" first="Gunnar" last="Kvalheim">Gunnar Kvalheim</name><affiliation><nlm:affiliation>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Constantinescu, Stefan N" sort="Constantinescu, Stefan N" uniqKey="Constantinescu S" first="Stefan N" last="Constantinescu">Stefan N. Constantinescu</name><affiliation><nlm:affiliation>Ludwig Institute for Cancer Research and de Duve Institute, Université Catholique de Louvain, 1200 Brussels, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Nerlov, Claus" sort="Nerlov, Claus" uniqKey="Nerlov C" first="Claus" last="Nerlov">Claus Nerlov</name><affiliation><nlm:affiliation>MRC Molecular Haematology Unit, Department of Haematology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Nilsson, Lars" sort="Nilsson, Lars" uniqKey="Nilsson L" first="Lars" last="Nilsson">Lars Nilsson</name><affiliation><nlm:affiliation>Skåne University Hospital, Lund 221 00, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J" last="Campbell">Peter J. Campbell</name><affiliation><nlm:affiliation>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sandberg, Rickard" sort="Sandberg, Rickard" uniqKey="Sandberg R" first="Rickard" last="Sandberg">Rickard Sandberg</name><affiliation><nlm:affiliation>Ludwig Institute for Cancer Research and Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Papaemmanuil, Elli" sort="Papaemmanuil, Elli" uniqKey="Papaemmanuil E" first="Elli" last="Papaemmanuil">Elli Papaemmanuil</name><affiliation><nlm:affiliation>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hellstrom Lindberg, Eva" sort="Hellstrom Lindberg, Eva" uniqKey="Hellstrom Lindberg E" first="Eva" last="Hellström-Lindberg">Eva Hellström-Lindberg</name><affiliation><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Linnarsson, Sten" sort="Linnarsson, Sten" uniqKey="Linnarsson S" first="Sten" last="Linnarsson">Sten Linnarsson</name><affiliation><nlm:affiliation>Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 65 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Jacobsen, Sten Eirik W" sort="Jacobsen, Sten Eirik W" uniqKey="Jacobsen S" first="Sten Eirik W" last="Jacobsen">Sten Eirik W. Jacobsen</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Departments of Cell and Molecular Biology, Medicine Huddinge, and Laboratory Medicine, Huddinge, Karolinska Institutet and Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Electronic address: sten.jacobsen@imm.ox.ac.uk.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24835589</idno><idno type="pmid">24835589</idno><idno type="doi">10.1016/j.ccr.2014.03.036</idno><idno type="wicri:Area/PubMed/Corpus">003703</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003703</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.</title><author><name sortKey="Woll, Petter S" sort="Woll, Petter S" uniqKey="Woll P" first="Petter S" last="Woll">Petter S. Woll</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kj Llquist, Una" sort="Kj Llquist, Una" uniqKey="Kj Llquist U" first="Una" last="Kj Llquist">Una Kj Llquist</name><affiliation><nlm:affiliation>Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 65 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Chowdhury, Onima" sort="Chowdhury, Onima" uniqKey="Chowdhury O" first="Onima" last="Chowdhury">Onima Chowdhury</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Doolittle, Helen" sort="Doolittle, Helen" uniqKey="Doolittle H" first="Helen" last="Doolittle">Helen Doolittle</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wedge, David C" sort="Wedge, David C" uniqKey="Wedge D" first="David C" last="Wedge">David C. Wedge</name><affiliation><nlm:affiliation>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Thongjuea, Supat" sort="Thongjuea, Supat" uniqKey="Thongjuea S" first="Supat" last="Thongjuea">Supat Thongjuea</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Erlandsson, Rikard" sort="Erlandsson, Rikard" uniqKey="Erlandsson R" first="Rikard" last="Erlandsson">Rikard Erlandsson</name><affiliation><nlm:affiliation>Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 65 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Ngara, Mtakai" sort="Ngara, Mtakai" uniqKey="Ngara M" first="Mtakai" last="Ngara">Mtakai Ngara</name><affiliation><nlm:affiliation>Ludwig Institute for Cancer Research and Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Anderson, Kristina" sort="Anderson, Kristina" uniqKey="Anderson K" first="Kristina" last="Anderson">Kristina Anderson</name><affiliation><nlm:affiliation>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Deng, Qiaolin" sort="Deng, Qiaolin" uniqKey="Deng Q" first="Qiaolin" last="Deng">Qiaolin Deng</name><affiliation><nlm:affiliation>Ludwig Institute for Cancer Research and Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Mead, Adam J" sort="Mead, Adam J" uniqKey="Mead A" first="Adam J" last="Mead">Adam J. Mead</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Stenson, Laura" sort="Stenson, Laura" uniqKey="Stenson L" first="Laura" last="Stenson">Laura Stenson</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Giustacchini, Alice" sort="Giustacchini, Alice" uniqKey="Giustacchini A" first="Alice" last="Giustacchini">Alice Giustacchini</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Duarte, Sara" sort="Duarte, Sara" uniqKey="Duarte S" first="Sara" last="Duarte">Sara Duarte</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Giannoulatou, Eleni" sort="Giannoulatou, Eleni" uniqKey="Giannoulatou E" first="Eleni" last="Giannoulatou">Eleni Giannoulatou</name><affiliation><nlm:affiliation>Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Taylor, Stephen" sort="Taylor, Stephen" uniqKey="Taylor S" first="Stephen" last="Taylor">Stephen Taylor</name><affiliation><nlm:affiliation>Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Karimi, Mohsen" sort="Karimi, Mohsen" uniqKey="Karimi M" first="Mohsen" last="Karimi">Mohsen Karimi</name><affiliation><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Scharenberg, Christian" sort="Scharenberg, Christian" uniqKey="Scharenberg C" first="Christian" last="Scharenberg">Christian Scharenberg</name><affiliation><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Mortera Blanco, Teresa" sort="Mortera Blanco, Teresa" uniqKey="Mortera Blanco T" first="Teresa" last="Mortera-Blanco">Teresa Mortera-Blanco</name><affiliation><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Macaulay, Iain C" sort="Macaulay, Iain C" uniqKey="Macaulay I" first="Iain C" last="Macaulay">Iain C. Macaulay</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Clark, Sally Ann" sort="Clark, Sally Ann" uniqKey="Clark S" first="Sally-Ann" last="Clark">Sally-Ann Clark</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Dybedal, Ingunn" sort="Dybedal, Ingunn" uniqKey="Dybedal I" first="Ingunn" last="Dybedal">Ingunn Dybedal</name><affiliation><nlm:affiliation>Department of Hematology, Oslo University Hospital, Rikshospitalet, 0130 Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Josefsen, Dag" sort="Josefsen, Dag" uniqKey="Josefsen D" first="Dag" last="Josefsen">Dag Josefsen</name><affiliation><nlm:affiliation>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Fenaux, Pierre" sort="Fenaux, Pierre" uniqKey="Fenaux P" first="Pierre" last="Fenaux">Pierre Fenaux</name><affiliation><nlm:affiliation>Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris (AP-HP), Service d'hématologie clinique, 93000 Bobigny, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hokland, Peter" sort="Hokland, Peter" uniqKey="Hokland P" first="Peter" last="Hokland">Peter Hokland</name><affiliation><nlm:affiliation>Department of Hematology, Aarhus University Hospital, 8000 Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Holm, Mette S" sort="Holm, Mette S" uniqKey="Holm M" first="Mette S" last="Holm">Mette S. Holm</name><affiliation><nlm:affiliation>Department of Hematology, Aarhus University Hospital, 8000 Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Cazzola, Mario" sort="Cazzola, Mario" uniqKey="Cazzola M" first="Mario" last="Cazzola">Mario Cazzola</name><affiliation><nlm:affiliation>Department of Molecular Medicine, University of Pavia, and Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Malcovati, Luca" sort="Malcovati, Luca" uniqKey="Malcovati L" first="Luca" last="Malcovati">Luca Malcovati</name><affiliation><nlm:affiliation>Department of Molecular Medicine, University of Pavia, and Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tauro, Sudhir" sort="Tauro, Sudhir" uniqKey="Tauro S" first="Sudhir" last="Tauro">Sudhir Tauro</name><affiliation><nlm:affiliation>Division of Medical Sciences, University of Dundee, Dundee DD1 9SY, Scotland, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bowen, David" sort="Bowen, David" uniqKey="Bowen D" first="David" last="Bowen">David Bowen</name><affiliation><nlm:affiliation>St. James Institute of Oncology, St. James Hospital, Leeds LS9 7TF, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Boultwood, Jacqueline" sort="Boultwood, Jacqueline" uniqKey="Boultwood J" first="Jacqueline" last="Boultwood">Jacqueline Boultwood</name><affiliation><nlm:affiliation>Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Pellagatti, Andrea" sort="Pellagatti, Andrea" uniqKey="Pellagatti A" first="Andrea" last="Pellagatti">Andrea Pellagatti</name><affiliation><nlm:affiliation>Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Pimanda, John E" sort="Pimanda, John E" uniqKey="Pimanda J" first="John E" last="Pimanda">John E. Pimanda</name><affiliation><nlm:affiliation>Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney 2052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Unnikrishnan, Ashwin" sort="Unnikrishnan, Ashwin" uniqKey="Unnikrishnan A" first="Ashwin" last="Unnikrishnan">Ashwin Unnikrishnan</name><affiliation><nlm:affiliation>Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney 2052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Vyas, Paresh" sort="Vyas, Paresh" uniqKey="Vyas P" first="Paresh" last="Vyas">Paresh Vyas</name><affiliation><nlm:affiliation>MRC Molecular Haematology Unit, Department of Haematology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Oxford University Hospital, NHS Trust, Oxford OX3 9DU, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Gohring, Gudrun" sort="Gohring, Gudrun" uniqKey="Gohring G" first="Gudrun" last="Göhring">Gudrun Göhring</name><affiliation><nlm:affiliation>Institute of Cell and Molecular Pathology, Hannover Medical School, 30625 Hannover, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schlegelberger, Brigitte" sort="Schlegelberger, Brigitte" uniqKey="Schlegelberger B" first="Brigitte" last="Schlegelberger">Brigitte Schlegelberger</name><affiliation><nlm:affiliation>Institute of Cell and Molecular Pathology, Hannover Medical School, 30625 Hannover, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Tobiasson, Magnus" sort="Tobiasson, Magnus" uniqKey="Tobiasson M" first="Magnus" last="Tobiasson">Magnus Tobiasson</name><affiliation><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Kvalheim, Gunnar" sort="Kvalheim, Gunnar" uniqKey="Kvalheim G" first="Gunnar" last="Kvalheim">Gunnar Kvalheim</name><affiliation><nlm:affiliation>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Constantinescu, Stefan N" sort="Constantinescu, Stefan N" uniqKey="Constantinescu S" first="Stefan N" last="Constantinescu">Stefan N. Constantinescu</name><affiliation><nlm:affiliation>Ludwig Institute for Cancer Research and de Duve Institute, Université Catholique de Louvain, 1200 Brussels, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Nerlov, Claus" sort="Nerlov, Claus" uniqKey="Nerlov C" first="Claus" last="Nerlov">Claus Nerlov</name><affiliation><nlm:affiliation>MRC Molecular Haematology Unit, Department of Haematology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Nilsson, Lars" sort="Nilsson, Lars" uniqKey="Nilsson L" first="Lars" last="Nilsson">Lars Nilsson</name><affiliation><nlm:affiliation>Skåne University Hospital, Lund 221 00, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J" last="Campbell">Peter J. Campbell</name><affiliation><nlm:affiliation>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sandberg, Rickard" sort="Sandberg, Rickard" uniqKey="Sandberg R" first="Rickard" last="Sandberg">Rickard Sandberg</name><affiliation><nlm:affiliation>Ludwig Institute for Cancer Research and Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Papaemmanuil, Elli" sort="Papaemmanuil, Elli" uniqKey="Papaemmanuil E" first="Elli" last="Papaemmanuil">Elli Papaemmanuil</name><affiliation><nlm:affiliation>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hellstrom Lindberg, Eva" sort="Hellstrom Lindberg, Eva" uniqKey="Hellstrom Lindberg E" first="Eva" last="Hellström-Lindberg">Eva Hellström-Lindberg</name><affiliation><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Linnarsson, Sten" sort="Linnarsson, Sten" uniqKey="Linnarsson S" first="Sten" last="Linnarsson">Sten Linnarsson</name><affiliation><nlm:affiliation>Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 65 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Jacobsen, Sten Eirik W" sort="Jacobsen, Sten Eirik W" uniqKey="Jacobsen S" first="Sten Eirik W" last="Jacobsen">Sten Eirik W. Jacobsen</name><affiliation><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Departments of Cell and Molecular Biology, Medicine Huddinge, and Laboratory Medicine, Huddinge, Karolinska Institutet and Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Electronic address: sten.jacobsen@imm.ox.ac.uk.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cancer cell</title><idno type="eISSN">1878-3686</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, CD (biosynthesis)</term><term>Antigens, CD (immunology)</term><term>Chromosome Deletion</term><term>Chromosomes, Human, Pair 5</term><term>Flow Cytometry</term><term>Gene Expression Profiling</term><term>Genetic Predisposition to Disease</term><term>Heterografts</term><term>Humans</term><term>Mice</term><term>Mice, Inbred NOD</term><term>Mutation</term><term>Myelodysplastic Syndromes (genetics)</term><term>Myelodysplastic Syndromes (immunology)</term><term>Myelodysplastic Syndromes (pathology)</term><term>Neoplastic Stem Cells (immunology)</term><term>Neoplastic Stem Cells (pathology)</term><term>Neoplastic Stem Cells (physiology)</term><term>Prognosis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antigens, CD</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, CD</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Myelodysplastic Syndromes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Myelodysplastic Syndromes</term><term>Neoplastic Stem Cells</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Myelodysplastic Syndromes</term><term>Neoplastic Stem Cells</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neoplastic Stem Cells</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chromosome Deletion</term><term>Chromosomes, Human, Pair 5</term><term>Flow Cytometry</term><term>Gene Expression Profiling</term><term>Genetic Predisposition to Disease</term><term>Heterografts</term><term>Humans</term><term>Mice</term><term>Mice, Inbred NOD</term><term>Mutation</term><term>Prognosis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Evidence for distinct human cancer stem cells (CSCs) remains contentious and the degree to which different cancer cells contribute to propagating malignancies in patients remains unexplored. In low- to intermediate-risk myelodysplastic syndromes (MDS), we establish the existence of rare multipotent MDS stem cells (MDS-SCs), and their hierarchical relationship to lineage-restricted MDS progenitors. All identified somatically acquired genetic lesions were backtracked to distinct MDS-SCs, establishing their distinct MDS-propagating function in vivo. In isolated del(5q)-MDS, acquisition of del(5q) preceded diverse recurrent driver mutations. Sequential analysis in del(5q)-MDS revealed genetic evolution in MDS-SCs and MDS-progenitors prior to leukemic transformation. These findings provide definitive evidence for rare human MDS-SCs in vivo, with extensive implications for the targeting of the cells required and sufficient for MDS-propagation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24835589</PMID><DateCreated><Year>2014</Year><Month>06</Month><Day>18</Day></DateCreated><DateCompleted><Year>2014</Year><Month>10</Month><Day>08</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-3686</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>6</Issue><PubDate><Year>2014</Year><Month>Jun</Month><Day>16</Day></PubDate></JournalIssue><Title>Cancer cell</Title><ISOAbbreviation>Cancer Cell</ISOAbbreviation></Journal><ArticleTitle>Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.</ArticleTitle><Pagination><MedlinePgn>794-808</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ccr.2014.03.036</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1535-6108(14)00134-2</ELocationID><Abstract><AbstractText>Evidence for distinct human cancer stem cells (CSCs) remains contentious and the degree to which different cancer cells contribute to propagating malignancies in patients remains unexplored. In low- to intermediate-risk myelodysplastic syndromes (MDS), we establish the existence of rare multipotent MDS stem cells (MDS-SCs), and their hierarchical relationship to lineage-restricted MDS progenitors. All identified somatically acquired genetic lesions were backtracked to distinct MDS-SCs, establishing their distinct MDS-propagating function in vivo. In isolated del(5q)-MDS, acquisition of del(5q) preceded diverse recurrent driver mutations. Sequential analysis in del(5q)-MDS revealed genetic evolution in MDS-SCs and MDS-progenitors prior to leukemic transformation. These findings provide definitive evidence for rare human MDS-SCs in vivo, with extensive implications for the targeting of the cells required and sufficient for MDS-propagation.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Woll</LastName><ForeName>Petter S</ForeName><Initials>PS</Initials><AffiliationInfo><Affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kjällquist</LastName><ForeName>Una</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 65 Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chowdhury</LastName><ForeName>Onima</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Doolittle</LastName><ForeName>Helen</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wedge</LastName><ForeName>David C</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thongjuea</LastName><ForeName>Supat</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Erlandsson</LastName><ForeName>Rikard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 65 Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ngara</LastName><ForeName>Mtakai</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Ludwig Institute for Cancer Research and Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anderson</LastName><ForeName>Kristina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deng</LastName><ForeName>Qiaolin</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Ludwig Institute for Cancer Research and Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mead</LastName><ForeName>Adam J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stenson</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giustacchini</LastName><ForeName>Alice</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duarte</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giannoulatou</LastName><ForeName>Eleni</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taylor</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karimi</LastName><ForeName>Mohsen</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scharenberg</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mortera-Blanco</LastName><ForeName>Teresa</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Macaulay</LastName><ForeName>Iain C</ForeName><Initials>IC</Initials><AffiliationInfo><Affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clark</LastName><ForeName>Sally-Ann</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dybedal</LastName><ForeName>Ingunn</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Hematology, Oslo University Hospital, Rikshospitalet, 0130 Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Josefsen</LastName><ForeName>Dag</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fenaux</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris (AP-HP), Service d'hématologie clinique, 93000 Bobigny, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hokland</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Hematology, Aarhus University Hospital, 8000 Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holm</LastName><ForeName>Mette S</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Department of Hematology, Aarhus University Hospital, 8000 Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cazzola</LastName><ForeName>Mario</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, University of Pavia, and Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malcovati</LastName><ForeName>Luca</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, University of Pavia, and Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tauro</LastName><ForeName>Sudhir</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Medical Sciences, University of Dundee, Dundee DD1 9SY, Scotland, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bowen</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>St. James Institute of Oncology, St. James Hospital, Leeds LS9 7TF, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boultwood</LastName><ForeName>Jacqueline</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pellagatti</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pimanda</LastName><ForeName>John E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney 2052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Unnikrishnan</LastName><ForeName>Ashwin</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney 2052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vyas</LastName><ForeName>Paresh</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>MRC Molecular Haematology Unit, Department of Haematology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Oxford University Hospital, NHS Trust, Oxford OX3 9DU, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Göhring</LastName><ForeName>Gudrun</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institute of Cell and Molecular Pathology, Hannover Medical School, 30625 Hannover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schlegelberger</LastName><ForeName>Brigitte</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institute of Cell and Molecular Pathology, Hannover Medical School, 30625 Hannover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tobiasson</LastName><ForeName>Magnus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kvalheim</LastName><ForeName>Gunnar</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Constantinescu</LastName><ForeName>Stefan N</ForeName><Initials>SN</Initials><AffiliationInfo><Affiliation>Ludwig Institute for Cancer Research and de Duve Institute, Université Catholique de Louvain, 1200 Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nerlov</LastName><ForeName>Claus</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>MRC Molecular Haematology Unit, Department of Haematology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nilsson</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Skåne University Hospital, Lund 221 00, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Campbell</LastName><ForeName>Peter J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sandberg</LastName><ForeName>Rickard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Ludwig Institute for Cancer Research and Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Papaemmanuil</LastName><ForeName>Elli</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hellström-Lindberg</LastName><ForeName>Eva</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Linnarsson</LastName><ForeName>Sten</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 65 Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacobsen</LastName><ForeName>Sten Eirik W</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Departments of Cell and Molecular Biology, Medicine Huddinge, and Laboratory Medicine, Huddinge, Karolinska Institutet and Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Electronic address: sten.jacobsen@imm.ox.ac.uk.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>GEO</DataBankName><AccessionNumberList><AccessionNumber>GSE55689</AccessionNumber></AccessionNumberList></DataBank><DataBank><DataBankName>SRA</DataBankName><AccessionNumberList><AccessionNumber>SRP039353</AccessionNumber></AccessionNumberList></DataBank></DataBankList><GrantList CompleteYN="Y"><Grant><GrantID>MC_PC_12020</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0902418</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>088340</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0701761</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MR/L006340/1</GrantID><Agency>Medical Research 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Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>05</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cancer Cell</MedlineTA><NlmUniqueID>101130617</NlmUniqueID><ISSNLinking>1535-6108</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015703">Antigens, CD</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Cancer Cell. 2014 Jun 16;25(6):713-4</RefSource><PMID Version="1">24937455</PMID></CommentsCorrections><CommentsCorrections RefType="ErratumIn"><RefSource>Cancer Cell. 2015 Apr 13;27(4):603-5</RefSource></CommentsCorrections><CommentsCorrections RefType="ErratumIn"><RefSource>Cancer Cell. 2014 Jun 16;25(6):861</RefSource></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015703" MajorTopicYN="N">Antigens, CD</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002872" MajorTopicYN="N">Chromosome Deletion</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002895" MajorTopicYN="N">Chromosomes, Human, Pair 5</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005434" MajorTopicYN="N">Flow Cytometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020869" MajorTopicYN="N">Gene Expression Profiling</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="N">Genetic Predisposition to Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064593" MajorTopicYN="N">Heterografts</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016688" MajorTopicYN="N">Mice, Inbred NOD</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009190" MajorTopicYN="N">Myelodysplastic Syndromes</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014411" MajorTopicYN="N">Neoplastic Stem Cells</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>10</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>02</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>03</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>5</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>5</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>10</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24835589</ArticleId><ArticleId IdType="pii">S1535-6108(14)00134-2</ArticleId><ArticleId IdType="doi">10.1016/j.ccr.2014.03.036</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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