AustralieFrV1, PubMed, Corpus, bibRecord, 003697

The sheep genome illuminates biology of the rumen and lipid metabolism.

Identifieur interne : 003697 ( PubMed/Corpus ); précédent : 003696; suivant : 003698

The sheep genome illuminates biology of the rumen and lipid metabolism.

Auteurs : Yu Jiang ; Min Xie ; Wenbin Chen ; Richard Talbot ; Jillian F. Maddox ; Thomas Faraut ; Chunhua Wu ; Donna M. Muzny ; Yuxiang Li ; Wenguang Zhang ; Jo-Ann Stanton ; Rudiger Brauning ; Wesley C. Barris ; Thibaut Hourlier ; Bronwen L. Aken ; Stephen M J. Searle ; David L. Adelson ; Chao Bian ; Graham R. Cam ; Yulin Chen ; Shifeng Cheng ; Udaya Desilva ; Karen Dixen ; Yang Dong ; Guangyi Fan ; Ian R. Franklin ; Shaoyin Fu ; Rui Guan ; Margaret A. Highland ; Michael E. Holder ; Guodong Huang ; Aaron B. Ingham ; Shalini N. Jhangiani ; Divya Kalra ; Christie L. Kovar ; Sandra L. Lee ; Weiqing Liu ; Xin Liu ; Changxin Lu ; Tian Lv ; Tittu Mathew ; Sean Mcwilliam ; Moira Menzies ; Shengkai Pan ; David Robelin ; Bertrand Servin ; David Townley ; Wenliang Wang ; Bin Wei ; Stephen N. White ; Xinhua Yang ; Chen Ye ; Yaojing Yue ; Peng Zeng ; Qing Zhou ; Jacob B. Hansen ; Karsten Kristensen ; Richard A. Gibbs ; Paul Flicek ; Christopher C. Warkup ; Huw E. Jones ; V Hutton Oddy ; Frank W. Nicholas ; John C. Mcewan ; James Kijas ; Jun Wang ; Kim C. Worley ; Alan L. Archibald ; Noelle Cockett ; Xun Xu ; Wen Wang ; Brian P. Dalrymple

Source :

Science (New York, N.Y.) [ 1095-9203 ] ; 2014.

RBID : pubmed:24904168

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Fatty Acids, Volatile (metabolism), Fatty Acids, Volatile (physiology), Gene Expression Regulation, Genome, Keratins, Hair-Specific (genetics), Lipid Metabolism (genetics), Lipid Metabolism (physiology), Molecular Sequence Data, Phylogeny, Rumen (metabolism), Rumen (physiology), Sheep, Domestic (classification), Sheep, Domestic (genetics), Sheep, Domestic (metabolism), Transcriptome, Wool (growth & development).
MESH :
- chemical , genetics : Keratins, Hair-Specific.
- chemical , metabolism : Fatty Acids, Volatile.
- chemical , physiology : Fatty Acids, Volatile.
- classification : Sheep, Domestic.
- genetics : Lipid Metabolism, Sheep, Domestic.
- growth & development : Wool.
- metabolism : Rumen, Sheep, Domestic.
- physiology : Lipid Metabolism, Rumen.
- Amino Acid Sequence, Animals, Gene Expression Regulation, Genome, Molecular Sequence Data, Phylogeny, Transcriptome.

Abstract

Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.

DOI: 10.1126/science.1252806
PubMed: 24904168

Links to Exploration step

pubmed:24904168

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The sheep genome illuminates biology of the rumen and lipid metabolism.</title>
<author><name sortKey="Jiang, Yu" sort="Jiang, Yu" uniqKey="Jiang Y" first="Yu" last="Jiang">Yu Jiang</name>
<affiliation><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Xie, Min" sort="Xie, Min" uniqKey="Xie M" first="Min" last="Xie">Min Xie</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chen, Wenbin" sort="Chen, Wenbin" uniqKey="Chen W" first="Wenbin" last="Chen">Wenbin Chen</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Talbot, Richard" sort="Talbot, Richard" uniqKey="Talbot R" first="Richard" last="Talbot">Richard Talbot</name>
<affiliation><nlm:affiliation>Ediburgh Genomics, University of Edinburgh, Easter Bush, Midlothian EH 25 9RG, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Maddox, Jillian F" sort="Maddox, Jillian F" uniqKey="Maddox J" first="Jillian F" last="Maddox">Jillian F. Maddox</name>
<affiliation><nlm:affiliation>Department of Veterinary Science, University of Melbourne, Victoria 3010, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Faraut, Thomas" sort="Faraut, Thomas" uniqKey="Faraut T" first="Thomas" last="Faraut">Thomas Faraut</name>
<affiliation><nlm:affiliation>INRA, Laboratoire de Génétique Cellulaire, UMR 444, Castanet-Tolosan F-31326, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wu, Chunhua" sort="Wu, Chunhua" uniqKey="Wu C" first="Chunhua" last="Wu">Chunhua Wu</name>
<affiliation><nlm:affiliation>Utah State University, Logan, UT 84322-1435-1435, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Muzny, Donna M" sort="Muzny, Donna M" uniqKey="Muzny D" first="Donna M" last="Muzny">Donna M. Muzny</name>
<affiliation><nlm:affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Li, Yuxiang" sort="Li, Yuxiang" uniqKey="Li Y" first="Yuxiang" last="Li">Yuxiang Li</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhang, Wenguang" sort="Zhang, Wenguang" uniqKey="Zhang W" first="Wenguang" last="Zhang">Wenguang Zhang</name>
<affiliation><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Stanton, Jo Ann" sort="Stanton, Jo Ann" uniqKey="Stanton J" first="Jo-Ann" last="Stanton">Jo-Ann Stanton</name>
<affiliation><nlm:affiliation>Department of Anatomy, University of Otago, Dunedin 9054, New Zealand.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Brauning, Rudiger" sort="Brauning, Rudiger" uniqKey="Brauning R" first="Rudiger" last="Brauning">Rudiger Brauning</name>
<affiliation><nlm:affiliation>AgResearch, Invermay Agricultural Centre, Mosgiel 9053, New Zealand.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Barris, Wesley C" sort="Barris, Wesley C" uniqKey="Barris W" first="Wesley C" last="Barris">Wesley C. Barris</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hourlier, Thibaut" sort="Hourlier, Thibaut" uniqKey="Hourlier T" first="Thibaut" last="Hourlier">Thibaut Hourlier</name>
<affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Aken, Bronwen L" sort="Aken, Bronwen L" uniqKey="Aken B" first="Bronwen L" last="Aken">Bronwen L. Aken</name>
<affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Searle, Stephen M J" sort="Searle, Stephen M J" uniqKey="Searle S" first="Stephen M J" last="Searle">Stephen M J. Searle</name>
<affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Adelson, David L" sort="Adelson, David L" uniqKey="Adelson D" first="David L" last="Adelson">David L. Adelson</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bian, Chao" sort="Bian, Chao" uniqKey="Bian C" first="Chao" last="Bian">Chao Bian</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cam, Graham R" sort="Cam, Graham R" uniqKey="Cam G" first="Graham R" last="Cam">Graham R. Cam</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chen, Yulin" sort="Chen, Yulin" uniqKey="Chen Y" first="Yulin" last="Chen">Yulin Chen</name>
<affiliation><nlm:affiliation>College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cheng, Shifeng" sort="Cheng, Shifeng" uniqKey="Cheng S" first="Shifeng" last="Cheng">Shifeng Cheng</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Desilva, Udaya" sort="Desilva, Udaya" uniqKey="Desilva U" first="Udaya" last="Desilva">Udaya Desilva</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dixen, Karen" sort="Dixen, Karen" uniqKey="Dixen K" first="Karen" last="Dixen">Karen Dixen</name>
<affiliation><nlm:affiliation>Department of Biology, University of Copenhagen, DK-2100 Copenhagen Ø, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dong, Yang" sort="Dong, Yang" uniqKey="Dong Y" first="Yang" last="Dong">Yang Dong</name>
<affiliation><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fan, Guangyi" sort="Fan, Guangyi" uniqKey="Fan G" first="Guangyi" last="Fan">Guangyi Fan</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Franklin, Ian R" sort="Franklin, Ian R" uniqKey="Franklin I" first="Ian R" last="Franklin">Ian R. Franklin</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fu, Shaoyin" sort="Fu, Shaoyin" uniqKey="Fu S" first="Shaoyin" last="Fu">Shaoyin Fu</name>
<affiliation><nlm:affiliation>Inner Mongolia Agricultural University, Hohhot 010018, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Guan, Rui" sort="Guan, Rui" uniqKey="Guan R" first="Rui" last="Guan">Rui Guan</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Highland, Margaret A" sort="Highland, Margaret A" uniqKey="Highland M" first="Margaret A" last="Highland">Margaret A. Highland</name>
<affiliation><nlm:affiliation>USDA-ARS Animal Disease Research Unit, Pullman, WA 99164 USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Holder, Michael E" sort="Holder, Michael E" uniqKey="Holder M" first="Michael E" last="Holder">Michael E. Holder</name>
<affiliation><nlm:affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Huang, Guodong" sort="Huang, Guodong" uniqKey="Huang G" first="Guodong" last="Huang">Guodong Huang</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ingham, Aaron B" sort="Ingham, Aaron B" uniqKey="Ingham A" first="Aaron B" last="Ingham">Aaron B. Ingham</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jhangiani, Shalini N" sort="Jhangiani, Shalini N" uniqKey="Jhangiani S" first="Shalini N" last="Jhangiani">Shalini N. Jhangiani</name>
<affiliation><nlm:affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kalra, Divya" sort="Kalra, Divya" uniqKey="Kalra D" first="Divya" last="Kalra">Divya Kalra</name>
<affiliation><nlm:affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kovar, Christie L" sort="Kovar, Christie L" uniqKey="Kovar C" first="Christie L" last="Kovar">Christie L. Kovar</name>
<affiliation><nlm:affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lee, Sandra L" sort="Lee, Sandra L" uniqKey="Lee S" first="Sandra L" last="Lee">Sandra L. Lee</name>
<affiliation><nlm:affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liu, Weiqing" sort="Liu, Weiqing" uniqKey="Liu W" first="Weiqing" last="Liu">Weiqing Liu</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liu, Xin" sort="Liu, Xin" uniqKey="Liu X" first="Xin" last="Liu">Xin Liu</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lu, Changxin" sort="Lu, Changxin" uniqKey="Lu C" first="Changxin" last="Lu">Changxin Lu</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lv, Tian" sort="Lv, Tian" uniqKey="Lv T" first="Tian" last="Lv">Tian Lv</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mathew, Tittu" sort="Mathew, Tittu" uniqKey="Mathew T" first="Tittu" last="Mathew">Tittu Mathew</name>
<affiliation><nlm:affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mcwilliam, Sean" sort="Mcwilliam, Sean" uniqKey="Mcwilliam S" first="Sean" last="Mcwilliam">Sean Mcwilliam</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Menzies, Moira" sort="Menzies, Moira" uniqKey="Menzies M" first="Moira" last="Menzies">Moira Menzies</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pan, Shengkai" sort="Pan, Shengkai" uniqKey="Pan S" first="Shengkai" last="Pan">Shengkai Pan</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Robelin, David" sort="Robelin, David" uniqKey="Robelin D" first="David" last="Robelin">David Robelin</name>
<affiliation><nlm:affiliation>INRA, Laboratoire de Génétique Cellulaire, UMR 444, Castanet-Tolosan F-31326, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Servin, Bertrand" sort="Servin, Bertrand" uniqKey="Servin B" first="Bertrand" last="Servin">Bertrand Servin</name>
<affiliation><nlm:affiliation>INRA, Laboratoire de Génétique Cellulaire, UMR 444, Castanet-Tolosan F-31326, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Townley, David" sort="Townley, David" uniqKey="Townley D" first="David" last="Townley">David Townley</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Wenliang" sort="Wang, Wenliang" uniqKey="Wang W" first="Wenliang" last="Wang">Wenliang Wang</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wei, Bin" sort="Wei, Bin" uniqKey="Wei B" first="Bin" last="Wei">Bin Wei</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="White, Stephen N" sort="White, Stephen N" uniqKey="White S" first="Stephen N" last="White">Stephen N. White</name>
<affiliation><nlm:affiliation>USDA-ARS Animal Disease Research Unit, Pullman, WA 99164 USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yang, Xinhua" sort="Yang, Xinhua" uniqKey="Yang X" first="Xinhua" last="Yang">Xinhua Yang</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ye, Chen" sort="Ye, Chen" uniqKey="Ye C" first="Chen" last="Ye">Chen Ye</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yue, Yaojing" sort="Yue, Yaojing" uniqKey="Yue Y" first="Yaojing" last="Yue">Yaojing Yue</name>
<affiliation><nlm:affiliation>Lanzhou Institute of Husbandry and Pharmaceutical Science, Lanzhou,730050,China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zeng, Peng" sort="Zeng, Peng" uniqKey="Zeng P" first="Peng" last="Zeng">Peng Zeng</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhou, Qing" sort="Zhou, Qing" uniqKey="Zhou Q" first="Qing" last="Zhou">Qing Zhou</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hansen, Jacob B" sort="Hansen, Jacob B" uniqKey="Hansen J" first="Jacob B" last="Hansen">Jacob B. Hansen</name>
<affiliation><nlm:affiliation>Department of Biology, University of Copenhagen, DK-2100 Copenhagen Ø, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kristensen, Karsten" sort="Kristensen, Karsten" uniqKey="Kristensen K" first="Karsten" last="Kristensen">Karsten Kristensen</name>
<affiliation><nlm:affiliation>Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gibbs, Richard A" sort="Gibbs, Richard A" uniqKey="Gibbs R" first="Richard A" last="Gibbs">Richard A. Gibbs</name>
<affiliation><nlm:affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Flicek, Paul" sort="Flicek, Paul" uniqKey="Flicek P" first="Paul" last="Flicek">Paul Flicek</name>
<affiliation><nlm:affiliation>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Warkup, Christopher C" sort="Warkup, Christopher C" uniqKey="Warkup C" first="Christopher C" last="Warkup">Christopher C. Warkup</name>
<affiliation><nlm:affiliation>Biosciences KTN, The Roslin Institute, Easter Bush, Midlothian, EH25 9RG, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jones, Huw E" sort="Jones, Huw E" uniqKey="Jones H" first="Huw E" last="Jones">Huw E. Jones</name>
<affiliation><nlm:affiliation>Biosciences KTN, The Roslin Institute, Easter Bush, Midlothian, EH25 9RG, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Oddy, V Hutton" sort="Oddy, V Hutton" uniqKey="Oddy V" first="V Hutton" last="Oddy">V Hutton Oddy</name>
<affiliation><nlm:affiliation>School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Nicholas, Frank W" sort="Nicholas, Frank W" uniqKey="Nicholas F" first="Frank W" last="Nicholas">Frank W. Nicholas</name>
<affiliation><nlm:affiliation>Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mcewan, John C" sort="Mcewan, John C" uniqKey="Mcewan J" first="John C" last="Mcewan">John C. Mcewan</name>
<affiliation><nlm:affiliation>AgResearch, Invermay Agricultural Centre, Mosgiel 9053, New Zealand.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kijas, James" sort="Kijas, James" uniqKey="Kijas J" first="James" last="Kijas">James Kijas</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Worley, Kim C" sort="Worley, Kim C" uniqKey="Worley K" first="Kim C" last="Worley">Kim C. Worley</name>
<affiliation><nlm:affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Archibald, Alan L" sort="Archibald, Alan L" uniqKey="Archibald A" first="Alan L" last="Archibald">Alan L. Archibald</name>
<affiliation><nlm:affiliation>The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Midlothian EH 25 9RG, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cockett, Noelle" sort="Cockett, Noelle" uniqKey="Cockett N" first="Noelle" last="Cockett">Noelle Cockett</name>
<affiliation><nlm:affiliation>Utah State University, Logan, UT 84322-1435-1435, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Xu, Xun" sort="Xu, Xun" uniqKey="Xu X" first="Xun" last="Xu">Xun Xu</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Wen" sort="Wang, Wen" uniqKey="Wang W" first="Wen" last="Wang">Wen Wang</name>
<affiliation><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dalrymple, Brian P" sort="Dalrymple, Brian P" uniqKey="Dalrymple B" first="Brian P" last="Dalrymple">Brian P. Dalrymple</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:24904168</idno>
<idno type="pmid">24904168</idno>
<idno type="doi">10.1126/science.1252806</idno>
<idno type="wicri:Area/PubMed/Corpus">003697</idno>
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</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The sheep genome illuminates biology of the rumen and lipid metabolism.</title>
<author><name sortKey="Jiang, Yu" sort="Jiang, Yu" uniqKey="Jiang Y" first="Yu" last="Jiang">Yu Jiang</name>
<affiliation><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Xie, Min" sort="Xie, Min" uniqKey="Xie M" first="Min" last="Xie">Min Xie</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chen, Wenbin" sort="Chen, Wenbin" uniqKey="Chen W" first="Wenbin" last="Chen">Wenbin Chen</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Talbot, Richard" sort="Talbot, Richard" uniqKey="Talbot R" first="Richard" last="Talbot">Richard Talbot</name>
<affiliation><nlm:affiliation>Ediburgh Genomics, University of Edinburgh, Easter Bush, Midlothian EH 25 9RG, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Maddox, Jillian F" sort="Maddox, Jillian F" uniqKey="Maddox J" first="Jillian F" last="Maddox">Jillian F. Maddox</name>
<affiliation><nlm:affiliation>Department of Veterinary Science, University of Melbourne, Victoria 3010, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Faraut, Thomas" sort="Faraut, Thomas" uniqKey="Faraut T" first="Thomas" last="Faraut">Thomas Faraut</name>
<affiliation><nlm:affiliation>INRA, Laboratoire de Génétique Cellulaire, UMR 444, Castanet-Tolosan F-31326, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wu, Chunhua" sort="Wu, Chunhua" uniqKey="Wu C" first="Chunhua" last="Wu">Chunhua Wu</name>
<affiliation><nlm:affiliation>Utah State University, Logan, UT 84322-1435-1435, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Muzny, Donna M" sort="Muzny, Donna M" uniqKey="Muzny D" first="Donna M" last="Muzny">Donna M. Muzny</name>
<affiliation><nlm:affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Li, Yuxiang" sort="Li, Yuxiang" uniqKey="Li Y" first="Yuxiang" last="Li">Yuxiang Li</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhang, Wenguang" sort="Zhang, Wenguang" uniqKey="Zhang W" first="Wenguang" last="Zhang">Wenguang Zhang</name>
<affiliation><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Stanton, Jo Ann" sort="Stanton, Jo Ann" uniqKey="Stanton J" first="Jo-Ann" last="Stanton">Jo-Ann Stanton</name>
<affiliation><nlm:affiliation>Department of Anatomy, University of Otago, Dunedin 9054, New Zealand.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Brauning, Rudiger" sort="Brauning, Rudiger" uniqKey="Brauning R" first="Rudiger" last="Brauning">Rudiger Brauning</name>
<affiliation><nlm:affiliation>AgResearch, Invermay Agricultural Centre, Mosgiel 9053, New Zealand.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Barris, Wesley C" sort="Barris, Wesley C" uniqKey="Barris W" first="Wesley C" last="Barris">Wesley C. Barris</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hourlier, Thibaut" sort="Hourlier, Thibaut" uniqKey="Hourlier T" first="Thibaut" last="Hourlier">Thibaut Hourlier</name>
<affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Aken, Bronwen L" sort="Aken, Bronwen L" uniqKey="Aken B" first="Bronwen L" last="Aken">Bronwen L. Aken</name>
<affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Searle, Stephen M J" sort="Searle, Stephen M J" uniqKey="Searle S" first="Stephen M J" last="Searle">Stephen M J. Searle</name>
<affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Adelson, David L" sort="Adelson, David L" uniqKey="Adelson D" first="David L" last="Adelson">David L. Adelson</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bian, Chao" sort="Bian, Chao" uniqKey="Bian C" first="Chao" last="Bian">Chao Bian</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cam, Graham R" sort="Cam, Graham R" uniqKey="Cam G" first="Graham R" last="Cam">Graham R. Cam</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chen, Yulin" sort="Chen, Yulin" uniqKey="Chen Y" first="Yulin" last="Chen">Yulin Chen</name>
<affiliation><nlm:affiliation>College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cheng, Shifeng" sort="Cheng, Shifeng" uniqKey="Cheng S" first="Shifeng" last="Cheng">Shifeng Cheng</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Desilva, Udaya" sort="Desilva, Udaya" uniqKey="Desilva U" first="Udaya" last="Desilva">Udaya Desilva</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dixen, Karen" sort="Dixen, Karen" uniqKey="Dixen K" first="Karen" last="Dixen">Karen Dixen</name>
<affiliation><nlm:affiliation>Department of Biology, University of Copenhagen, DK-2100 Copenhagen Ø, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dong, Yang" sort="Dong, Yang" uniqKey="Dong Y" first="Yang" last="Dong">Yang Dong</name>
<affiliation><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fan, Guangyi" sort="Fan, Guangyi" uniqKey="Fan G" first="Guangyi" last="Fan">Guangyi Fan</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Franklin, Ian R" sort="Franklin, Ian R" uniqKey="Franklin I" first="Ian R" last="Franklin">Ian R. Franklin</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fu, Shaoyin" sort="Fu, Shaoyin" uniqKey="Fu S" first="Shaoyin" last="Fu">Shaoyin Fu</name>
<affiliation><nlm:affiliation>Inner Mongolia Agricultural University, Hohhot 010018, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Guan, Rui" sort="Guan, Rui" uniqKey="Guan R" first="Rui" last="Guan">Rui Guan</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Highland, Margaret A" sort="Highland, Margaret A" uniqKey="Highland M" first="Margaret A" last="Highland">Margaret A. Highland</name>
<affiliation><nlm:affiliation>USDA-ARS Animal Disease Research Unit, Pullman, WA 99164 USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Holder, Michael E" sort="Holder, Michael E" uniqKey="Holder M" first="Michael E" last="Holder">Michael E. Holder</name>
<affiliation><nlm:affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Huang, Guodong" sort="Huang, Guodong" uniqKey="Huang G" first="Guodong" last="Huang">Guodong Huang</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ingham, Aaron B" sort="Ingham, Aaron B" uniqKey="Ingham A" first="Aaron B" last="Ingham">Aaron B. Ingham</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jhangiani, Shalini N" sort="Jhangiani, Shalini N" uniqKey="Jhangiani S" first="Shalini N" last="Jhangiani">Shalini N. Jhangiani</name>
<affiliation><nlm:affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kalra, Divya" sort="Kalra, Divya" uniqKey="Kalra D" first="Divya" last="Kalra">Divya Kalra</name>
<affiliation><nlm:affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kovar, Christie L" sort="Kovar, Christie L" uniqKey="Kovar C" first="Christie L" last="Kovar">Christie L. Kovar</name>
<affiliation><nlm:affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lee, Sandra L" sort="Lee, Sandra L" uniqKey="Lee S" first="Sandra L" last="Lee">Sandra L. Lee</name>
<affiliation><nlm:affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liu, Weiqing" sort="Liu, Weiqing" uniqKey="Liu W" first="Weiqing" last="Liu">Weiqing Liu</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liu, Xin" sort="Liu, Xin" uniqKey="Liu X" first="Xin" last="Liu">Xin Liu</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lu, Changxin" sort="Lu, Changxin" uniqKey="Lu C" first="Changxin" last="Lu">Changxin Lu</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lv, Tian" sort="Lv, Tian" uniqKey="Lv T" first="Tian" last="Lv">Tian Lv</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mathew, Tittu" sort="Mathew, Tittu" uniqKey="Mathew T" first="Tittu" last="Mathew">Tittu Mathew</name>
<affiliation><nlm:affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mcwilliam, Sean" sort="Mcwilliam, Sean" uniqKey="Mcwilliam S" first="Sean" last="Mcwilliam">Sean Mcwilliam</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Menzies, Moira" sort="Menzies, Moira" uniqKey="Menzies M" first="Moira" last="Menzies">Moira Menzies</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pan, Shengkai" sort="Pan, Shengkai" uniqKey="Pan S" first="Shengkai" last="Pan">Shengkai Pan</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Robelin, David" sort="Robelin, David" uniqKey="Robelin D" first="David" last="Robelin">David Robelin</name>
<affiliation><nlm:affiliation>INRA, Laboratoire de Génétique Cellulaire, UMR 444, Castanet-Tolosan F-31326, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Servin, Bertrand" sort="Servin, Bertrand" uniqKey="Servin B" first="Bertrand" last="Servin">Bertrand Servin</name>
<affiliation><nlm:affiliation>INRA, Laboratoire de Génétique Cellulaire, UMR 444, Castanet-Tolosan F-31326, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Townley, David" sort="Townley, David" uniqKey="Townley D" first="David" last="Townley">David Townley</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Wenliang" sort="Wang, Wenliang" uniqKey="Wang W" first="Wenliang" last="Wang">Wenliang Wang</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wei, Bin" sort="Wei, Bin" uniqKey="Wei B" first="Bin" last="Wei">Bin Wei</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="White, Stephen N" sort="White, Stephen N" uniqKey="White S" first="Stephen N" last="White">Stephen N. White</name>
<affiliation><nlm:affiliation>USDA-ARS Animal Disease Research Unit, Pullman, WA 99164 USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yang, Xinhua" sort="Yang, Xinhua" uniqKey="Yang X" first="Xinhua" last="Yang">Xinhua Yang</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ye, Chen" sort="Ye, Chen" uniqKey="Ye C" first="Chen" last="Ye">Chen Ye</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yue, Yaojing" sort="Yue, Yaojing" uniqKey="Yue Y" first="Yaojing" last="Yue">Yaojing Yue</name>
<affiliation><nlm:affiliation>Lanzhou Institute of Husbandry and Pharmaceutical Science, Lanzhou,730050,China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zeng, Peng" sort="Zeng, Peng" uniqKey="Zeng P" first="Peng" last="Zeng">Peng Zeng</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhou, Qing" sort="Zhou, Qing" uniqKey="Zhou Q" first="Qing" last="Zhou">Qing Zhou</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hansen, Jacob B" sort="Hansen, Jacob B" uniqKey="Hansen J" first="Jacob B" last="Hansen">Jacob B. Hansen</name>
<affiliation><nlm:affiliation>Department of Biology, University of Copenhagen, DK-2100 Copenhagen Ø, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kristensen, Karsten" sort="Kristensen, Karsten" uniqKey="Kristensen K" first="Karsten" last="Kristensen">Karsten Kristensen</name>
<affiliation><nlm:affiliation>Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gibbs, Richard A" sort="Gibbs, Richard A" uniqKey="Gibbs R" first="Richard A" last="Gibbs">Richard A. Gibbs</name>
<affiliation><nlm:affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Flicek, Paul" sort="Flicek, Paul" uniqKey="Flicek P" first="Paul" last="Flicek">Paul Flicek</name>
<affiliation><nlm:affiliation>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Warkup, Christopher C" sort="Warkup, Christopher C" uniqKey="Warkup C" first="Christopher C" last="Warkup">Christopher C. Warkup</name>
<affiliation><nlm:affiliation>Biosciences KTN, The Roslin Institute, Easter Bush, Midlothian, EH25 9RG, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jones, Huw E" sort="Jones, Huw E" uniqKey="Jones H" first="Huw E" last="Jones">Huw E. Jones</name>
<affiliation><nlm:affiliation>Biosciences KTN, The Roslin Institute, Easter Bush, Midlothian, EH25 9RG, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Oddy, V Hutton" sort="Oddy, V Hutton" uniqKey="Oddy V" first="V Hutton" last="Oddy">V Hutton Oddy</name>
<affiliation><nlm:affiliation>School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Nicholas, Frank W" sort="Nicholas, Frank W" uniqKey="Nicholas F" first="Frank W" last="Nicholas">Frank W. Nicholas</name>
<affiliation><nlm:affiliation>Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mcewan, John C" sort="Mcewan, John C" uniqKey="Mcewan J" first="John C" last="Mcewan">John C. Mcewan</name>
<affiliation><nlm:affiliation>AgResearch, Invermay Agricultural Centre, Mosgiel 9053, New Zealand.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kijas, James" sort="Kijas, James" uniqKey="Kijas J" first="James" last="Kijas">James Kijas</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Worley, Kim C" sort="Worley, Kim C" uniqKey="Worley K" first="Kim C" last="Worley">Kim C. Worley</name>
<affiliation><nlm:affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Archibald, Alan L" sort="Archibald, Alan L" uniqKey="Archibald A" first="Alan L" last="Archibald">Alan L. Archibald</name>
<affiliation><nlm:affiliation>The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Midlothian EH 25 9RG, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cockett, Noelle" sort="Cockett, Noelle" uniqKey="Cockett N" first="Noelle" last="Cockett">Noelle Cockett</name>
<affiliation><nlm:affiliation>Utah State University, Logan, UT 84322-1435-1435, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Xu, Xun" sort="Xu, Xun" uniqKey="Xu X" first="Xun" last="Xu">Xun Xu</name>
<affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen 518083, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Wen" sort="Wang, Wen" uniqKey="Wang W" first="Wen" last="Wang">Wen Wang</name>
<affiliation><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dalrymple, Brian P" sort="Dalrymple, Brian P" uniqKey="Dalrymple B" first="Brian P" last="Dalrymple">Brian P. Dalrymple</name>
<affiliation><nlm:affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Science (New York, N.Y.)</title>
<idno type="eISSN">1095-9203</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Fatty Acids, Volatile (metabolism)</term>
<term>Fatty Acids, Volatile (physiology)</term>
<term>Gene Expression Regulation</term>
<term>Genome</term>
<term>Keratins, Hair-Specific (genetics)</term>
<term>Lipid Metabolism (genetics)</term>
<term>Lipid Metabolism (physiology)</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Rumen (metabolism)</term>
<term>Rumen (physiology)</term>
<term>Sheep, Domestic (classification)</term>
<term>Sheep, Domestic (genetics)</term>
<term>Sheep, Domestic (metabolism)</term>
<term>Transcriptome</term>
<term>Wool (growth & development)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Keratins, Hair-Specific</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fatty Acids, Volatile</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Fatty Acids, Volatile</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Sheep, Domestic</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lipid Metabolism</term>
<term>Sheep, Domestic</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Wool</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Rumen</term>
<term>Sheep, Domestic</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lipid Metabolism</term>
<term>Rumen</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Gene Expression Regulation</term>
<term>Genome</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Transcriptome</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24904168</PMID>
<DateCreated><Year>2014</Year>
<Month>06</Month>
<Day>06</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>06</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1095-9203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>344</Volume>
<Issue>6188</Issue>
<PubDate><Year>2014</Year>
<Month>Jun</Month>
<Day>06</Day>
</PubDate>
</JournalIssue>
<Title>Science (New York, N.Y.)</Title>
<ISOAbbreviation>Science</ISOAbbreviation>
</Journal>
<ArticleTitle>The sheep genome illuminates biology of the rumen and lipid metabolism.</ArticleTitle>
<Pagination><MedlinePgn>1168-1173</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1126/science.1252806</ELocationID>
<Abstract><AbstractText>Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.</AbstractText>
<CopyrightInformation>Copyright © 2014, American Association for the Advancement of Science.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Jiang</LastName>
<ForeName>Yu</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y" EqualContrib="Y"><LastName>Xie</LastName>
<ForeName>Min</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y" EqualContrib="Y"><LastName>Chen</LastName>
<ForeName>Wenbin</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Talbot</LastName>
<ForeName>Richard</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Ediburgh Genomics, University of Edinburgh, Easter Bush, Midlothian EH 25 9RG, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Maddox</LastName>
<ForeName>Jillian F</ForeName>
<Initials>JF</Initials>
<AffiliationInfo><Affiliation>Department of Veterinary Science, University of Melbourne, Victoria 3010, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Faraut</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>INRA, Laboratoire de Génétique Cellulaire, UMR 444, Castanet-Tolosan F-31326, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Chunhua</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Utah State University, Logan, UT 84322-1435-1435, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Muzny</LastName>
<ForeName>Donna M</ForeName>
<Initials>DM</Initials>
<AffiliationInfo><Affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Yuxiang</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Wenguang</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Inner Mongolia Agricultural University, Hohhot 010018, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of ATCG, Nei Mongol Bio-Information, Hohhot, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stanton</LastName>
<ForeName>Jo-Ann</ForeName>
<Initials>JA</Initials>
<AffiliationInfo><Affiliation>Department of Anatomy, University of Otago, Dunedin 9054, New Zealand.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brauning</LastName>
<ForeName>Rudiger</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>AgResearch, Invermay Agricultural Centre, Mosgiel 9053, New Zealand.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barris</LastName>
<ForeName>Wesley C</ForeName>
<Initials>WC</Initials>
<AffiliationInfo><Affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hourlier</LastName>
<ForeName>Thibaut</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Aken</LastName>
<ForeName>Bronwen L</ForeName>
<Initials>BL</Initials>
<AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Searle</LastName>
<ForeName>Stephen M J</ForeName>
<Initials>SMJ</Initials>
<AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Adelson</LastName>
<ForeName>David L</ForeName>
<Initials>DL</Initials>
<AffiliationInfo><Affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bian</LastName>
<ForeName>Chao</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cam</LastName>
<ForeName>Graham R</ForeName>
<Initials>GR</Initials>
<AffiliationInfo><Affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Yulin</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cheng</LastName>
<ForeName>Shifeng</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>DeSilva</LastName>
<ForeName>Udaya</ForeName>
<Initials>U</Initials>
<AffiliationInfo><Affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dixen</LastName>
<ForeName>Karen</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Biology, University of Copenhagen, DK-2100 Copenhagen Ø, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dong</LastName>
<ForeName>Yang</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fan</LastName>
<ForeName>Guangyi</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Franklin</LastName>
<ForeName>Ian R</ForeName>
<Initials>IR</Initials>
<AffiliationInfo><Affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fu</LastName>
<ForeName>Shaoyin</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Inner Mongolia Agricultural University, Hohhot 010018, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guan</LastName>
<ForeName>Rui</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Highland</LastName>
<ForeName>Margaret A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>USDA-ARS Animal Disease Research Unit, Pullman, WA 99164 USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Veterinary Microbiology & Pathology, Washington State University, Pullman, WA 99164 USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Holder</LastName>
<ForeName>Michael E</ForeName>
<Initials>ME</Initials>
<AffiliationInfo><Affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Guodong</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ingham</LastName>
<ForeName>Aaron B</ForeName>
<Initials>AB</Initials>
<AffiliationInfo><Affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jhangiani</LastName>
<ForeName>Shalini N</ForeName>
<Initials>SN</Initials>
<AffiliationInfo><Affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kalra</LastName>
<ForeName>Divya</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kovar</LastName>
<ForeName>Christie L</ForeName>
<Initials>CL</Initials>
<AffiliationInfo><Affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Sandra L</ForeName>
<Initials>SL</Initials>
<AffiliationInfo><Affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Weiqing</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Xin</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lu</LastName>
<ForeName>Changxin</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lv</LastName>
<ForeName>Tian</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mathew</LastName>
<ForeName>Tittu</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McWilliam</LastName>
<ForeName>Sean</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Menzies</LastName>
<ForeName>Moira</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pan</LastName>
<ForeName>Shengkai</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Robelin</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>INRA, Laboratoire de Génétique Cellulaire, UMR 444, Castanet-Tolosan F-31326, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Servin</LastName>
<ForeName>Bertrand</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>INRA, Laboratoire de Génétique Cellulaire, UMR 444, Castanet-Tolosan F-31326, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Townley</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Wenliang</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wei</LastName>
<ForeName>Bin</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Maize Research Institute, Sichuan Agricultural University, Chengdu 611130, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>White</LastName>
<ForeName>Stephen N</ForeName>
<Initials>SN</Initials>
<AffiliationInfo><Affiliation>USDA-ARS Animal Disease Research Unit, Pullman, WA 99164 USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Veterinary Microbiology & Pathology, Washington State University, Pullman, WA 99164 USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Xinhua</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ye</LastName>
<ForeName>Chen</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yue</LastName>
<ForeName>Yaojing</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Lanzhou Institute of Husbandry and Pharmaceutical Science, Lanzhou,730050,China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zeng</LastName>
<ForeName>Peng</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Qing</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hansen</LastName>
<ForeName>Jacob B</ForeName>
<Initials>JB</Initials>
<AffiliationInfo><Affiliation>Department of Biology, University of Copenhagen, DK-2100 Copenhagen Ø, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kristensen</LastName>
<ForeName>Karsten</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gibbs</LastName>
<ForeName>Richard A</ForeName>
<Initials>RA</Initials>
<AffiliationInfo><Affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Flicek</LastName>
<ForeName>Paul</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Warkup</LastName>
<ForeName>Christopher C</ForeName>
<Initials>CC</Initials>
<AffiliationInfo><Affiliation>Biosciences KTN, The Roslin Institute, Easter Bush, Midlothian, EH25 9RG, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jones</LastName>
<ForeName>Huw E</ForeName>
<Initials>HE</Initials>
<AffiliationInfo><Affiliation>Biosciences KTN, The Roslin Institute, Easter Bush, Midlothian, EH25 9RG, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Oddy</LastName>
<ForeName>V Hutton</ForeName>
<Initials>VH</Initials>
<AffiliationInfo><Affiliation>School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nicholas</LastName>
<ForeName>Frank W</ForeName>
<Initials>FW</Initials>
<AffiliationInfo><Affiliation>Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McEwan</LastName>
<ForeName>John C</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>AgResearch, Invermay Agricultural Centre, Mosgiel 9053, New Zealand.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kijas</LastName>
<ForeName>James</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Jun</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Princess Al Jawhara Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Macau University of Science and Technology, Macau 999078, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Worley</LastName>
<ForeName>Kim C</ForeName>
<Initials>KC</Initials>
<AffiliationInfo><Affiliation>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Archibald</LastName>
<ForeName>Alan L</ForeName>
<Initials>AL</Initials>
<AffiliationInfo><Affiliation>The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Midlothian EH 25 9RG, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cockett</LastName>
<ForeName>Noelle</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Utah State University, Logan, UT 84322-1435-1435, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Xun</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen 518083, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Wen</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dalrymple</LastName>
<ForeName>Brian P</ForeName>
<Initials>BP</Initials>
<AffiliationInfo><Affiliation>CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
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<Agency>Biotechnology and Biological Sciences Research Council</Agency>
<Country>United Kingdom</Country>
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<Agency>Wellcome Trust</Agency>
<Country>United Kingdom</Country>
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<Agency>Biotechnology and Biological Sciences Research Council</Agency>
<Country>United Kingdom</Country>
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Serveur d'exploration sur les relations entre la France et l'Australie

The sheep genome illuminates biology of the rumen and lipid metabolism.

The sheep genome illuminates biology of the rumen and lipid metabolism.

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