Rare mutations in RINT1 predispose carriers to breast and Lynch syndrome-spectrum cancers.
Identifieur interne : 003640 ( PubMed/Corpus ); précédent : 003639; suivant : 003641Rare mutations in RINT1 predispose carriers to breast and Lynch syndrome-spectrum cancers.
Auteurs : Daniel J. Park ; Kayoko Tao ; Florence Le Calvez-Kelm ; Tu Nguyen-Dumont ; Nivonirina Robinot ; Fleur Hammet ; Fabrice Odefrey ; Helen Tsimiklis ; Zhi L. Teo ; Louise B. Thingholm ; Erin L. Young ; Catherine Voegele ; Andrew Lonie ; Bernard J. Pope ; Terrell C. Roane ; Russell Bell ; Hao Hu ; Shankaracharya ; Chad D. Huff ; Jonathan Ellis ; Jun Li ; Igor V. Makunin ; Esther M. John ; Irene L. Andrulis ; Mary B. Terry ; Mary Daly ; Saundra S. Buys ; Carrie Snyder ; Henry T. Lynch ; Peter Devilee ; Graham G. Giles ; John L. Hopper ; Bing-Jian Feng ; Fabienne Lesueur ; Sean V. Tavtigian ; Melissa C. Southey ; David E. GoldgarSource :
- Cancer discovery [ 2159-8290 ] ; 2014.
English descriptors
- KwdEn :
- Breast Neoplasms (genetics), Case-Control Studies, Cell Cycle Proteins (genetics), Colorectal Neoplasms, Hereditary Nonpolyposis (genetics), Exome, Female, Genetic Predisposition to Disease, Genetic Variation, High-Throughput Nucleotide Sequencing, Humans, Male, Mutation, Pedigree, Sequence Analysis, DNA.
- MESH :
- chemical , genetics : Cell Cycle Proteins.
- genetics : Breast Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis.
- Case-Control Studies, Exome, Female, Genetic Predisposition to Disease, Genetic Variation, High-Throughput Nucleotide Sequencing, Humans, Male, Mutation, Pedigree, Sequence Analysis, DNA.
Abstract
Approximately half of the familial aggregation of breast cancer remains unexplained. A multiple-case breast cancer family exome-sequencing study identified three likely pathogenic mutations in RINT1 (NM_021930.4) not present in public sequencing databases: RINT1 c.343C>T (p.Q115X), c.1132_1134del (p.M378del), and c.1207G>T (p.D403Y). On the basis of this finding, a population-based case-control mutation-screening study was conducted that identified 29 carriers of rare (minor allele frequency < 0.5%), likely pathogenic variants: 23 in 1,313 early-onset breast cancer cases and six in 1,123 frequency-matched controls [OR, 3.24; 95% confidence interval (CI), 1.29-8.17; P = 0.013]. RINT1 mutation screening of probands from 798 multiple-case breast cancer families identified four additional carriers of rare genetic variants. Analysis of the incidence of first primary cancers in families of women carrying RINT1 mutations estimated that carriers were at increased risk of Lynch syndrome-spectrum cancers [standardized incidence ratio (SIR), 3.35; 95% CI, 1.7-6.0; P = 0.005], particularly for relatives diagnosed with cancer under the age of 60 years (SIR, 10.9; 95% CI, 4.7-21; P = 0.0003).
DOI: 10.1158/2159-8290.CD-14-0212
PubMed: 25050558
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pubmed:25050558Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Rare mutations in RINT1 predispose carriers to breast and Lynch syndrome-spectrum cancers.</title><author><name sortKey="Park, Daniel J" sort="Park, Daniel J" uniqKey="Park D" first="Daniel J" last="Park">Daniel J. Park</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</nlm:affiliation></affiliation></author><author><name sortKey="Tao, Kayoko" sort="Tao, Kayoko" uniqKey="Tao K" first="Kayoko" last="Tao">Kayoko Tao</name><affiliation><nlm:affiliation>Oncological Sciences and.</nlm:affiliation></affiliation></author><author><name sortKey="Le Calvez Kelm, Florence" sort="Le Calvez Kelm, Florence" uniqKey="Le Calvez Kelm F" first="Florence" last="Le Calvez-Kelm">Florence Le Calvez-Kelm</name><affiliation><nlm:affiliation>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon;</nlm:affiliation></affiliation></author><author><name sortKey="Nguyen Dumont, Tu" sort="Nguyen Dumont, Tu" uniqKey="Nguyen Dumont T" first="Tu" last="Nguyen-Dumont">Tu Nguyen-Dumont</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</nlm:affiliation></affiliation></author><author><name sortKey="Robinot, Nivonirina" sort="Robinot, Nivonirina" uniqKey="Robinot N" first="Nivonirina" last="Robinot">Nivonirina Robinot</name><affiliation><nlm:affiliation>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon;</nlm:affiliation></affiliation></author><author><name sortKey="Hammet, Fleur" sort="Hammet, Fleur" uniqKey="Hammet F" first="Fleur" last="Hammet">Fleur Hammet</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</nlm:affiliation></affiliation></author><author><name sortKey="Odefrey, Fabrice" sort="Odefrey, Fabrice" uniqKey="Odefrey F" first="Fabrice" last="Odefrey">Fabrice Odefrey</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</nlm:affiliation></affiliation></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</nlm:affiliation></affiliation></author><author><name sortKey="Teo, Zhi L" sort="Teo, Zhi L" uniqKey="Teo Z" first="Zhi L" last="Teo">Zhi L. Teo</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</nlm:affiliation></affiliation></author><author><name sortKey="Thingholm, Louise B" sort="Thingholm, Louise B" uniqKey="Thingholm L" first="Louise B" last="Thingholm">Louise B. Thingholm</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</nlm:affiliation></affiliation></author><author><name sortKey="Young, Erin L" sort="Young, Erin L" uniqKey="Young E" first="Erin L" last="Young">Erin L. Young</name><affiliation><nlm:affiliation>Oncological Sciences and.</nlm:affiliation></affiliation></author><author><name sortKey="Voegele, Catherine" sort="Voegele, Catherine" uniqKey="Voegele C" first="Catherine" last="Voegele">Catherine Voegele</name><affiliation><nlm:affiliation>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon;</nlm:affiliation></affiliation></author><author><name sortKey="Lonie, Andrew" sort="Lonie, Andrew" uniqKey="Lonie A" first="Andrew" last="Lonie">Andrew Lonie</name><affiliation><nlm:affiliation>Victorian Life Sciences Computation Initiative;</nlm:affiliation></affiliation></author><author><name sortKey="Pope, Bernard J" sort="Pope, Bernard J" uniqKey="Pope B" first="Bernard J" last="Pope">Bernard J. Pope</name><affiliation><nlm:affiliation>Department of Computing and Information Systems; Victorian Life Sciences Computation Initiative;</nlm:affiliation></affiliation></author><author><name sortKey="Roane, Terrell C" sort="Roane, Terrell C" uniqKey="Roane T" first="Terrell C" last="Roane">Terrell C. Roane</name><affiliation><nlm:affiliation>University of Texas at Austin, Austin;</nlm:affiliation></affiliation></author><author><name sortKey="Bell, Russell" sort="Bell, Russell" uniqKey="Bell R" first="Russell" last="Bell">Russell Bell</name><affiliation><nlm:affiliation>Oncological Sciences and.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Hao" sort="Hu, Hao" uniqKey="Hu H" first="Hao" last="Hu">Hao Hu</name><affiliation><nlm:affiliation>Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas;</nlm:affiliation></affiliation></author><author><name sortKey="Shankaracharya" sort="Shankaracharya" uniqKey="Shankaracharya" last="Shankaracharya">Shankaracharya</name><affiliation><nlm:affiliation>Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas;</nlm:affiliation></affiliation></author><author><name sortKey="Huff, Chad D" sort="Huff, Chad D" uniqKey="Huff C" first="Chad D" last="Huff">Chad D. Huff</name><affiliation><nlm:affiliation>Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas;</nlm:affiliation></affiliation></author><author><name sortKey="Ellis, Jonathan" sort="Ellis, Jonathan" uniqKey="Ellis J" first="Jonathan" last="Ellis">Jonathan Ellis</name><affiliation><nlm:affiliation>The QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia; Departments of.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Jun" sort="Li, Jun" uniqKey="Li J" first="Jun" last="Li">Jun Li</name><affiliation><nlm:affiliation>The QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia; Departments of.</nlm:affiliation></affiliation></author><author><name sortKey="Makunin, Igor V" sort="Makunin, Igor V" uniqKey="Makunin I" first="Igor V" last="Makunin">Igor V. Makunin</name><affiliation><nlm:affiliation>The QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia; Departments of.</nlm:affiliation></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name><affiliation><nlm:affiliation>Cancer Prevention Institute of California, Fremont; Department of Health Research and Policy, Stanford Cancer Institute, Stanford, California;</nlm:affiliation></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:affiliation>Department of Molecular Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada;</nlm:affiliation></affiliation></author><author><name sortKey="Terry, Mary B" sort="Terry, Mary B" uniqKey="Terry M" first="Mary B" last="Terry">Mary B. Terry</name><affiliation><nlm:affiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York;</nlm:affiliation></affiliation></author><author><name sortKey="Daly, Mary" sort="Daly, Mary" uniqKey="Daly M" first="Mary" last="Daly">Mary Daly</name><affiliation><nlm:affiliation>Fox Chase Cancer Center, Philadelphia, Pennsylvania;</nlm:affiliation></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S" last="Buys">Saundra S. Buys</name><affiliation><nlm:affiliation>Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah;</nlm:affiliation></affiliation></author><author><name sortKey="Snyder, Carrie" sort="Snyder, Carrie" uniqKey="Snyder C" first="Carrie" last="Snyder">Carrie Snyder</name><affiliation><nlm:affiliation>Department of Preventive Medicine, Creighton University, Omaha, Nebraska;</nlm:affiliation></affiliation></author><author><name sortKey="Lynch, Henry T" sort="Lynch, Henry T" uniqKey="Lynch H" first="Henry T" last="Lynch">Henry T. Lynch</name><affiliation><nlm:affiliation>Department of Preventive Medicine, Creighton University, Omaha, Nebraska;</nlm:affiliation></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:affiliation>Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands; and.</nlm:affiliation></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne; Centre for Cancer Epidemiology, The Cancer Council Victoria, Carlton, Victoria;</nlm:affiliation></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne; School of Public Health, Seoul National University, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Feng, Bing Jian" sort="Feng, Bing Jian" uniqKey="Feng B" first="Bing-Jian" last="Feng">Bing-Jian Feng</name><affiliation><nlm:affiliation>Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah;</nlm:affiliation></affiliation></author><author><name sortKey="Lesueur, Fabienne" sort="Lesueur, Fabienne" uniqKey="Lesueur F" first="Fabienne" last="Lesueur">Fabienne Lesueur</name><affiliation><nlm:affiliation>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon; Genetic Epidemiology of Cancer Team, Institut National de la Santé et de la Recherche Medicale (INSERM), U900, Institut Curie, Mines ParisTech, Paris, France;</nlm:affiliation></affiliation></author><author><name sortKey="Tavtigian, Sean V" sort="Tavtigian, Sean V" uniqKey="Tavtigian S" first="Sean V" last="Tavtigian">Sean V. Tavtigian</name><affiliation><nlm:affiliation>Oncological Sciences and.</nlm:affiliation></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology; msouthey@unimelb.edu.au david.goldgar@hsc.utah.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E" last="Goldgar">David E. Goldgar</name><affiliation><nlm:affiliation>Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah; msouthey@unimelb.edu.au david.goldgar@hsc.utah.edu.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25050558</idno><idno type="pmid">25050558</idno><idno type="doi">10.1158/2159-8290.CD-14-0212</idno><idno type="wicri:Area/PubMed/Corpus">003640</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003640</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Rare mutations in RINT1 predispose carriers to breast and Lynch syndrome-spectrum cancers.</title><author><name sortKey="Park, Daniel J" sort="Park, Daniel J" uniqKey="Park D" first="Daniel J" last="Park">Daniel J. Park</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</nlm:affiliation></affiliation></author><author><name sortKey="Tao, Kayoko" sort="Tao, Kayoko" uniqKey="Tao K" first="Kayoko" last="Tao">Kayoko Tao</name><affiliation><nlm:affiliation>Oncological Sciences and.</nlm:affiliation></affiliation></author><author><name sortKey="Le Calvez Kelm, Florence" sort="Le Calvez Kelm, Florence" uniqKey="Le Calvez Kelm F" first="Florence" last="Le Calvez-Kelm">Florence Le Calvez-Kelm</name><affiliation><nlm:affiliation>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon;</nlm:affiliation></affiliation></author><author><name sortKey="Nguyen Dumont, Tu" sort="Nguyen Dumont, Tu" uniqKey="Nguyen Dumont T" first="Tu" last="Nguyen-Dumont">Tu Nguyen-Dumont</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</nlm:affiliation></affiliation></author><author><name sortKey="Robinot, Nivonirina" sort="Robinot, Nivonirina" uniqKey="Robinot N" first="Nivonirina" last="Robinot">Nivonirina Robinot</name><affiliation><nlm:affiliation>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon;</nlm:affiliation></affiliation></author><author><name sortKey="Hammet, Fleur" sort="Hammet, Fleur" uniqKey="Hammet F" first="Fleur" last="Hammet">Fleur Hammet</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</nlm:affiliation></affiliation></author><author><name sortKey="Odefrey, Fabrice" sort="Odefrey, Fabrice" uniqKey="Odefrey F" first="Fabrice" last="Odefrey">Fabrice Odefrey</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</nlm:affiliation></affiliation></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</nlm:affiliation></affiliation></author><author><name sortKey="Teo, Zhi L" sort="Teo, Zhi L" uniqKey="Teo Z" first="Zhi L" last="Teo">Zhi L. Teo</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</nlm:affiliation></affiliation></author><author><name sortKey="Thingholm, Louise B" sort="Thingholm, Louise B" uniqKey="Thingholm L" first="Louise B" last="Thingholm">Louise B. Thingholm</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</nlm:affiliation></affiliation></author><author><name sortKey="Young, Erin L" sort="Young, Erin L" uniqKey="Young E" first="Erin L" last="Young">Erin L. Young</name><affiliation><nlm:affiliation>Oncological Sciences and.</nlm:affiliation></affiliation></author><author><name sortKey="Voegele, Catherine" sort="Voegele, Catherine" uniqKey="Voegele C" first="Catherine" last="Voegele">Catherine Voegele</name><affiliation><nlm:affiliation>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon;</nlm:affiliation></affiliation></author><author><name sortKey="Lonie, Andrew" sort="Lonie, Andrew" uniqKey="Lonie A" first="Andrew" last="Lonie">Andrew Lonie</name><affiliation><nlm:affiliation>Victorian Life Sciences Computation Initiative;</nlm:affiliation></affiliation></author><author><name sortKey="Pope, Bernard J" sort="Pope, Bernard J" uniqKey="Pope B" first="Bernard J" last="Pope">Bernard J. Pope</name><affiliation><nlm:affiliation>Department of Computing and Information Systems; Victorian Life Sciences Computation Initiative;</nlm:affiliation></affiliation></author><author><name sortKey="Roane, Terrell C" sort="Roane, Terrell C" uniqKey="Roane T" first="Terrell C" last="Roane">Terrell C. Roane</name><affiliation><nlm:affiliation>University of Texas at Austin, Austin;</nlm:affiliation></affiliation></author><author><name sortKey="Bell, Russell" sort="Bell, Russell" uniqKey="Bell R" first="Russell" last="Bell">Russell Bell</name><affiliation><nlm:affiliation>Oncological Sciences and.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Hao" sort="Hu, Hao" uniqKey="Hu H" first="Hao" last="Hu">Hao Hu</name><affiliation><nlm:affiliation>Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas;</nlm:affiliation></affiliation></author><author><name sortKey="Shankaracharya" sort="Shankaracharya" uniqKey="Shankaracharya" last="Shankaracharya">Shankaracharya</name><affiliation><nlm:affiliation>Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas;</nlm:affiliation></affiliation></author><author><name sortKey="Huff, Chad D" sort="Huff, Chad D" uniqKey="Huff C" first="Chad D" last="Huff">Chad D. Huff</name><affiliation><nlm:affiliation>Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas;</nlm:affiliation></affiliation></author><author><name sortKey="Ellis, Jonathan" sort="Ellis, Jonathan" uniqKey="Ellis J" first="Jonathan" last="Ellis">Jonathan Ellis</name><affiliation><nlm:affiliation>The QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia; Departments of.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Jun" sort="Li, Jun" uniqKey="Li J" first="Jun" last="Li">Jun Li</name><affiliation><nlm:affiliation>The QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia; Departments of.</nlm:affiliation></affiliation></author><author><name sortKey="Makunin, Igor V" sort="Makunin, Igor V" uniqKey="Makunin I" first="Igor V" last="Makunin">Igor V. Makunin</name><affiliation><nlm:affiliation>The QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia; Departments of.</nlm:affiliation></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name><affiliation><nlm:affiliation>Cancer Prevention Institute of California, Fremont; Department of Health Research and Policy, Stanford Cancer Institute, Stanford, California;</nlm:affiliation></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:affiliation>Department of Molecular Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada;</nlm:affiliation></affiliation></author><author><name sortKey="Terry, Mary B" sort="Terry, Mary B" uniqKey="Terry M" first="Mary B" last="Terry">Mary B. Terry</name><affiliation><nlm:affiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York;</nlm:affiliation></affiliation></author><author><name sortKey="Daly, Mary" sort="Daly, Mary" uniqKey="Daly M" first="Mary" last="Daly">Mary Daly</name><affiliation><nlm:affiliation>Fox Chase Cancer Center, Philadelphia, Pennsylvania;</nlm:affiliation></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S" last="Buys">Saundra S. Buys</name><affiliation><nlm:affiliation>Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah;</nlm:affiliation></affiliation></author><author><name sortKey="Snyder, Carrie" sort="Snyder, Carrie" uniqKey="Snyder C" first="Carrie" last="Snyder">Carrie Snyder</name><affiliation><nlm:affiliation>Department of Preventive Medicine, Creighton University, Omaha, Nebraska;</nlm:affiliation></affiliation></author><author><name sortKey="Lynch, Henry T" sort="Lynch, Henry T" uniqKey="Lynch H" first="Henry T" last="Lynch">Henry T. Lynch</name><affiliation><nlm:affiliation>Department of Preventive Medicine, Creighton University, Omaha, Nebraska;</nlm:affiliation></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:affiliation>Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands; and.</nlm:affiliation></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne; Centre for Cancer Epidemiology, The Cancer Council Victoria, Carlton, Victoria;</nlm:affiliation></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne; School of Public Health, Seoul National University, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Feng, Bing Jian" sort="Feng, Bing Jian" uniqKey="Feng B" first="Bing-Jian" last="Feng">Bing-Jian Feng</name><affiliation><nlm:affiliation>Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah;</nlm:affiliation></affiliation></author><author><name sortKey="Lesueur, Fabienne" sort="Lesueur, Fabienne" uniqKey="Lesueur F" first="Fabienne" last="Lesueur">Fabienne Lesueur</name><affiliation><nlm:affiliation>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon; Genetic Epidemiology of Cancer Team, Institut National de la Santé et de la Recherche Medicale (INSERM), U900, Institut Curie, Mines ParisTech, Paris, France;</nlm:affiliation></affiliation></author><author><name sortKey="Tavtigian, Sean V" sort="Tavtigian, Sean V" uniqKey="Tavtigian S" first="Sean V" last="Tavtigian">Sean V. Tavtigian</name><affiliation><nlm:affiliation>Oncological Sciences and.</nlm:affiliation></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology; msouthey@unimelb.edu.au david.goldgar@hsc.utah.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E" last="Goldgar">David E. Goldgar</name><affiliation><nlm:affiliation>Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah; msouthey@unimelb.edu.au david.goldgar@hsc.utah.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cancer discovery</title><idno type="eISSN">2159-8290</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast Neoplasms (genetics)</term><term>Case-Control Studies</term><term>Cell Cycle Proteins (genetics)</term><term>Colorectal Neoplasms, Hereditary Nonpolyposis (genetics)</term><term>Exome</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genetic Variation</term><term>High-Throughput Nucleotide Sequencing</term><term>Humans</term><term>Male</term><term>Mutation</term><term>Pedigree</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cell Cycle Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Breast Neoplasms</term><term>Colorectal Neoplasms, Hereditary Nonpolyposis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Exome</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genetic Variation</term><term>High-Throughput Nucleotide Sequencing</term><term>Humans</term><term>Male</term><term>Mutation</term><term>Pedigree</term><term>Sequence Analysis, DNA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Approximately half of the familial aggregation of breast cancer remains unexplained. A multiple-case breast cancer family exome-sequencing study identified three likely pathogenic mutations in RINT1 (NM_021930.4) not present in public sequencing databases: RINT1 c.343C>T (p.Q115X), c.1132_1134del (p.M378del), and c.1207G>T (p.D403Y). On the basis of this finding, a population-based case-control mutation-screening study was conducted that identified 29 carriers of rare (minor allele frequency < 0.5%), likely pathogenic variants: 23 in 1,313 early-onset breast cancer cases and six in 1,123 frequency-matched controls [OR, 3.24; 95% confidence interval (CI), 1.29-8.17; P = 0.013]. RINT1 mutation screening of probands from 798 multiple-case breast cancer families identified four additional carriers of rare genetic variants. Analysis of the incidence of first primary cancers in families of women carrying RINT1 mutations estimated that carriers were at increased risk of Lynch syndrome-spectrum cancers [standardized incidence ratio (SIR), 3.35; 95% CI, 1.7-6.0; P = 0.005], particularly for relatives diagnosed with cancer under the age of 60 years (SIR, 10.9; 95% CI, 4.7-21; P = 0.0003).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25050558</PMID><DateCreated><Year>2014</Year><Month>07</Month><Day>23</Day></DateCreated><DateCompleted><Year>2015</Year><Month>02</Month><Day>24</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2159-8290</ISSN><JournalIssue CitedMedium="Internet"><Volume>4</Volume><Issue>7</Issue><PubDate><Year>2014</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Cancer discovery</Title><ISOAbbreviation>Cancer Discov</ISOAbbreviation></Journal><ArticleTitle>Rare mutations in RINT1 predispose carriers to breast and Lynch syndrome-spectrum cancers.</ArticleTitle><Pagination><MedlinePgn>804-15</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1158/2159-8290.CD-14-0212</ELocationID><Abstract><AbstractText Label="UNLABELLED">Approximately half of the familial aggregation of breast cancer remains unexplained. A multiple-case breast cancer family exome-sequencing study identified three likely pathogenic mutations in RINT1 (NM_021930.4) not present in public sequencing databases: RINT1 c.343C>T (p.Q115X), c.1132_1134del (p.M378del), and c.1207G>T (p.D403Y). On the basis of this finding, a population-based case-control mutation-screening study was conducted that identified 29 carriers of rare (minor allele frequency < 0.5%), likely pathogenic variants: 23 in 1,313 early-onset breast cancer cases and six in 1,123 frequency-matched controls [OR, 3.24; 95% confidence interval (CI), 1.29-8.17; P = 0.013]. RINT1 mutation screening of probands from 798 multiple-case breast cancer families identified four additional carriers of rare genetic variants. Analysis of the incidence of first primary cancers in families of women carrying RINT1 mutations estimated that carriers were at increased risk of Lynch syndrome-spectrum cancers [standardized incidence ratio (SIR), 3.35; 95% CI, 1.7-6.0; P = 0.005], particularly for relatives diagnosed with cancer under the age of 60 years (SIR, 10.9; 95% CI, 4.7-21; P = 0.0003).</AbstractText><AbstractText Label="SIGNIFICANCE" NlmCategory="CONCLUSIONS">The work described in this study adds RINT1 to the growing list of genes in which rare sequence variants are associated with intermediate levels of breast cancer risk. Given that RINT1 is also associated with a spectrum of cancers with mismatch repair defects, these findings have clinical applications and raise interesting biological questions.</AbstractText><CopyrightInformation>©2014 American Association for Cancer Research.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Daniel J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tao</LastName><ForeName>Kayoko</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Oncological Sciences and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Calvez-Kelm</LastName><ForeName>Florence</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nguyen-Dumont</LastName><ForeName>Tu</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robinot</LastName><ForeName>Nivonirina</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hammet</LastName><ForeName>Fleur</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Odefrey</LastName><ForeName>Fabrice</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsimiklis</LastName><ForeName>Helen</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teo</LastName><ForeName>Zhi L</ForeName><Initials>ZL</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thingholm</LastName><ForeName>Louise B</ForeName><Initials>LB</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Laboratory, Department of Pathology;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Young</LastName><ForeName>Erin L</ForeName><Initials>EL</Initials><AffiliationInfo><Affiliation>Oncological Sciences and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Voegele</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lonie</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Victorian Life Sciences Computation Initiative;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pope</LastName><ForeName>Bernard J</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>Department of Computing and Information Systems; Victorian Life Sciences Computation Initiative;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roane</LastName><ForeName>Terrell C</ForeName><Initials>TC</Initials><AffiliationInfo><Affiliation>University of Texas at Austin, Austin;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bell</LastName><ForeName>Russell</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Oncological Sciences and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Hao</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shankaracharya</LastName><AffiliationInfo><Affiliation>Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huff</LastName><ForeName>Chad D</ForeName><Initials>CD</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ellis</LastName><ForeName>Jonathan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>The QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia; Departments of.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Jun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>The QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia; Departments of.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Makunin</LastName><ForeName>Igor V</ForeName><Initials>IV</Initials><AffiliationInfo><Affiliation>The QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia; Departments of.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>John</LastName><ForeName>Esther M</ForeName><Initials>EM</Initials><AffiliationInfo><Affiliation>Cancer Prevention Institute of California, Fremont; Department of Health Research and Policy, Stanford Cancer Institute, Stanford, California;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andrulis</LastName><ForeName>Irene L</ForeName><Initials>IL</Initials><AffiliationInfo><Affiliation>Department of Molecular Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Terry</LastName><ForeName>Mary B</ForeName><Initials>MB</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Daly</LastName><ForeName>Mary</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Fox Chase Cancer Center, Philadelphia, Pennsylvania;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buys</LastName><ForeName>Saundra S</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Snyder</LastName><ForeName>Carrie</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, Creighton University, Omaha, Nebraska;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lynch</LastName><ForeName>Henry T</ForeName><Initials>HT</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, Creighton University, Omaha, Nebraska;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Devilee</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giles</LastName><ForeName>Graham G</ForeName><Initials>GG</Initials><AffiliationInfo><Affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne; Centre for Cancer Epidemiology, The Cancer Council Victoria, Carlton, Victoria;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hopper</LastName><ForeName>John L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne; School of Public Health, Seoul National University, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feng</LastName><ForeName>Bing-Jian</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lesueur</LastName><ForeName>Fabienne</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon; Genetic Epidemiology of Cancer Team, Institut National de la Santé et de la Recherche Medicale (INSERM), U900, Institut Curie, Mines ParisTech, Paris, France;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tavtigian</LastName><ForeName>Sean V</ForeName><Initials>SV</Initials><AffiliationInfo><Affiliation>Oncological Sciences and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Southey</LastName><ForeName>Melissa C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Laboratory, Department of Pathology; msouthey@unimelb.edu.au david.goldgar@hsc.utah.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goldgar</LastName><ForeName>David E</ForeName><Initials>DE</Initials><AffiliationInfo><Affiliation>Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah; msouthey@unimelb.edu.au david.goldgar@hsc.utah.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>U01 CA069638</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA155767</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 CA016672</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA164920</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA121245</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30CA042014</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant><Grant><GrantID>R01CA155767</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 CA042014</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01CA121245</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>05</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cancer 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UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018797" MajorTopicYN="N">Cell Cycle Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003123" MajorTopicYN="N">Colorectal Neoplasms, Hereditary Nonpolyposis</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059472" MajorTopicYN="N">Exome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="N">Genetic Predisposition to Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014644" MajorTopicYN="N">Genetic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059014" MajorTopicYN="N">High-Throughput Nucleotide Sequencing</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010375" MajorTopicYN="N">Pedigree</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS592360</OtherID><OtherID Source="NLM">PMC4234633</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>7</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>7</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:25050558" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |