Melanoma arising from a long-standing pigmented trichoblastoma: clinicopathologic study with complementary aCGH/mutational analysis.
Identifieur interne : 003547 ( PubMed/Corpus ); précédent : 003546; suivant : 003548Melanoma arising from a long-standing pigmented trichoblastoma: clinicopathologic study with complementary aCGH/mutational analysis.
Auteurs : Gilles Benaïm ; Christine Castillo ; Michelle Houang ; Lydia Dejardin ; Christine Mateus ; Qing Wang ; Daniel Pissaloux ; Gorana Tomasic ; Bernard Cribier ; Arnaud De La FouchardièreSource :
- The American Journal of dermatopathology [ 1533-0311 ] ; 2014.
English descriptors
- KwdEn :
- Biomarkers, Tumor (analysis), Biomarkers, Tumor (genetics), Biopsy, Comparative Genomic Hybridization, DNA Mutational Analysis, Fatal Outcome, GTP Phosphohydrolases (genetics), Humans, Immunohistochemistry, Male, Melanins (analysis), Melanocytes (chemistry), Melanocytes (pathology), Melanoma (chemistry), Melanoma (genetics), Melanoma (secondary), Membrane Proteins (genetics), Middle Aged, Mutation, Neoplasms, Adnexal and Skin Appendage (chemistry), Neoplasms, Adnexal and Skin Appendage (genetics), Neoplasms, Adnexal and Skin Appendage (pathology), Neoplasms, Adnexal and Skin Appendage (surgery), Skin Neoplasms (chemistry), Skin Neoplasms (genetics), Skin Neoplasms (pathology), Time Factors.
- MESH :
- chemical , analysis : Biomarkers, Tumor, Melanins.
- chemical , genetics : Biomarkers, Tumor, GTP Phosphohydrolases, Membrane Proteins.
- chemistry : Melanocytes, Melanoma, Neoplasms, Adnexal and Skin Appendage, Skin Neoplasms.
- genetics : Melanoma, Neoplasms, Adnexal and Skin Appendage, Skin Neoplasms.
- pathology : Melanocytes, Neoplasms, Adnexal and Skin Appendage, Skin Neoplasms.
- secondary : Melanoma.
- surgery : Neoplasms, Adnexal and Skin Appendage.
- Biopsy, Comparative Genomic Hybridization, DNA Mutational Analysis, Fatal Outcome, Humans, Immunohistochemistry, Male, Middle Aged, Mutation, Time Factors.
Abstract
Trichoblastoma is a benign cutaneous adnexal tumor, composed mostly of follicular germinative cells. Its pigmented variant is colonized by numerous dendritic melanocytes. So far, only one case in the literature describes a combination of trichoblastoma and melanoma. We report the case of a 62-year-old man who had a slow-growing mass of the left flank present since childhood. This 8-cm mass was surgically removed when it became ulcerated and associated with axillary lymph nodes. Histologically, this tumor was strictly dermal and composed of 2 intermingled components. Large sheets of atypical, proliferating epithelioid cells predominated. Dispersed solid nests or cribriform epithelial islets encased in fibrous tissue were also seen. Some nests displayed a massive colonization by pigmented dendritic melanocytes. On immunohistochemical staining, the sheets of atypical cells expressed focally but strongly S100 protein, MelanA, HMB45, and MiTF. Epithelial structures diffusely expressed pancytokeratin AE1/AE3, KL1, and pleckstrin homology-like domain, family A, member 1. Based on these results, we diagnosed an intradermal melanoma, possibly developed from dendritic melanocytes colonizing a giant pigmented trichoblastoma. Direct sequencing of the melanoma revealed a rarely described NRAS mutation c.34G>T (G12C). Array comparative genomic hybridization displayed a complex profile somewhat divergent from standard melanoma profiles. The patient died of widespread metastatic disease 8 months after initial diagnosis.
DOI: 10.1097/DAD.0000000000000034
PubMed: 24335517
Links to Exploration step
pubmed:24335517Le document en format XML
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<term>GTP Phosphohydrolases (genetics)</term>
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<term>Melanins (analysis)</term>
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<front><div type="abstract" xml:lang="en">Trichoblastoma is a benign cutaneous adnexal tumor, composed mostly of follicular germinative cells. Its pigmented variant is colonized by numerous dendritic melanocytes. So far, only one case in the literature describes a combination of trichoblastoma and melanoma. We report the case of a 62-year-old man who had a slow-growing mass of the left flank present since childhood. This 8-cm mass was surgically removed when it became ulcerated and associated with axillary lymph nodes. Histologically, this tumor was strictly dermal and composed of 2 intermingled components. Large sheets of atypical, proliferating epithelioid cells predominated. Dispersed solid nests or cribriform epithelial islets encased in fibrous tissue were also seen. Some nests displayed a massive colonization by pigmented dendritic melanocytes. On immunohistochemical staining, the sheets of atypical cells expressed focally but strongly S100 protein, MelanA, HMB45, and MiTF. Epithelial structures diffusely expressed pancytokeratin AE1/AE3, KL1, and pleckstrin homology-like domain, family A, member 1. Based on these results, we diagnosed an intradermal melanoma, possibly developed from dendritic melanocytes colonizing a giant pigmented trichoblastoma. Direct sequencing of the melanoma revealed a rarely described NRAS mutation c.34G>T (G12C). Array comparative genomic hybridization displayed a complex profile somewhat divergent from standard melanoma profiles. The patient died of widespread metastatic disease 8 months after initial diagnosis.</div>
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<Abstract><AbstractText>Trichoblastoma is a benign cutaneous adnexal tumor, composed mostly of follicular germinative cells. Its pigmented variant is colonized by numerous dendritic melanocytes. So far, only one case in the literature describes a combination of trichoblastoma and melanoma. We report the case of a 62-year-old man who had a slow-growing mass of the left flank present since childhood. This 8-cm mass was surgically removed when it became ulcerated and associated with axillary lymph nodes. Histologically, this tumor was strictly dermal and composed of 2 intermingled components. Large sheets of atypical, proliferating epithelioid cells predominated. Dispersed solid nests or cribriform epithelial islets encased in fibrous tissue were also seen. Some nests displayed a massive colonization by pigmented dendritic melanocytes. On immunohistochemical staining, the sheets of atypical cells expressed focally but strongly S100 protein, MelanA, HMB45, and MiTF. Epithelial structures diffusely expressed pancytokeratin AE1/AE3, KL1, and pleckstrin homology-like domain, family A, member 1. Based on these results, we diagnosed an intradermal melanoma, possibly developed from dendritic melanocytes colonizing a giant pigmented trichoblastoma. Direct sequencing of the melanoma revealed a rarely described NRAS mutation c.34G>T (G12C). Array comparative genomic hybridization displayed a complex profile somewhat divergent from standard melanoma profiles. The patient died of widespread metastatic disease 8 months after initial diagnosis.</AbstractText>
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