Melanoma arising from a long-standing pigmented trichoblastoma: clinicopathologic study with complementary aCGH/mutational analysis.
Identifieur interne : 003547 ( PubMed/Corpus ); précédent : 003546; suivant : 003548Melanoma arising from a long-standing pigmented trichoblastoma: clinicopathologic study with complementary aCGH/mutational analysis.
Auteurs : Gilles Benaïm ; Christine Castillo ; Michelle Houang ; Lydia Dejardin ; Christine Mateus ; Qing Wang ; Daniel Pissaloux ; Gorana Tomasic ; Bernard Cribier ; Arnaud De La FouchardièreSource :
- The American Journal of dermatopathology [ 1533-0311 ] ; 2014.
English descriptors
- KwdEn :
- Biomarkers, Tumor (analysis), Biomarkers, Tumor (genetics), Biopsy, Comparative Genomic Hybridization, DNA Mutational Analysis, Fatal Outcome, GTP Phosphohydrolases (genetics), Humans, Immunohistochemistry, Male, Melanins (analysis), Melanocytes (chemistry), Melanocytes (pathology), Melanoma (chemistry), Melanoma (genetics), Melanoma (secondary), Membrane Proteins (genetics), Middle Aged, Mutation, Neoplasms, Adnexal and Skin Appendage (chemistry), Neoplasms, Adnexal and Skin Appendage (genetics), Neoplasms, Adnexal and Skin Appendage (pathology), Neoplasms, Adnexal and Skin Appendage (surgery), Skin Neoplasms (chemistry), Skin Neoplasms (genetics), Skin Neoplasms (pathology), Time Factors.
- MESH :
- chemical , analysis : Biomarkers, Tumor, Melanins.
- chemical , genetics : Biomarkers, Tumor, GTP Phosphohydrolases, Membrane Proteins.
- chemistry : Melanocytes, Melanoma, Neoplasms, Adnexal and Skin Appendage, Skin Neoplasms.
- genetics : Melanoma, Neoplasms, Adnexal and Skin Appendage, Skin Neoplasms.
- pathology : Melanocytes, Neoplasms, Adnexal and Skin Appendage, Skin Neoplasms.
- secondary : Melanoma.
- surgery : Neoplasms, Adnexal and Skin Appendage.
- Biopsy, Comparative Genomic Hybridization, DNA Mutational Analysis, Fatal Outcome, Humans, Immunohistochemistry, Male, Middle Aged, Mutation, Time Factors.
Abstract
Trichoblastoma is a benign cutaneous adnexal tumor, composed mostly of follicular germinative cells. Its pigmented variant is colonized by numerous dendritic melanocytes. So far, only one case in the literature describes a combination of trichoblastoma and melanoma. We report the case of a 62-year-old man who had a slow-growing mass of the left flank present since childhood. This 8-cm mass was surgically removed when it became ulcerated and associated with axillary lymph nodes. Histologically, this tumor was strictly dermal and composed of 2 intermingled components. Large sheets of atypical, proliferating epithelioid cells predominated. Dispersed solid nests or cribriform epithelial islets encased in fibrous tissue were also seen. Some nests displayed a massive colonization by pigmented dendritic melanocytes. On immunohistochemical staining, the sheets of atypical cells expressed focally but strongly S100 protein, MelanA, HMB45, and MiTF. Epithelial structures diffusely expressed pancytokeratin AE1/AE3, KL1, and pleckstrin homology-like domain, family A, member 1. Based on these results, we diagnosed an intradermal melanoma, possibly developed from dendritic melanocytes colonizing a giant pigmented trichoblastoma. Direct sequencing of the melanoma revealed a rarely described NRAS mutation c.34G>T (G12C). Array comparative genomic hybridization displayed a complex profile somewhat divergent from standard melanoma profiles. The patient died of widespread metastatic disease 8 months after initial diagnosis.
DOI: 10.1097/DAD.0000000000000034
PubMed: 24335517
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pubmed:24335517Le document en format XML
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†Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, Australia; ‡Northern Translational Cancer Research Unit, Sydney Medical School, University of Sydney, Sydney, Australia; §Laboratoire de Pathologie, St Savine, France; ¶Services de Dermatologie, and ‖Pathologie, Institut Gustave Roussy, Villejuif, France; and **Service de Dermatologie, Hôpitaux de Strasbourg, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Castillo, Christine" sort="Castillo, Christine" uniqKey="Castillo C" first="Christine" last="Castillo">Christine Castillo</name></author><author><name sortKey="Houang, Michelle" sort="Houang, Michelle" uniqKey="Houang M" first="Michelle" last="Houang">Michelle Houang</name></author><author><name sortKey="Dejardin, Lydia" sort="Dejardin, Lydia" uniqKey="Dejardin L" first="Lydia" last="Dejardin">Lydia Dejardin</name></author><author><name sortKey="Mateus, Christine" sort="Mateus, Christine" uniqKey="Mateus C" first="Christine" last="Mateus">Christine Mateus</name></author><author><name sortKey="Wang, Qing" sort="Wang, Qing" uniqKey="Wang Q" first="Qing" last="Wang">Qing Wang</name></author><author><name sortKey="Pissaloux, Daniel" sort="Pissaloux, Daniel" uniqKey="Pissaloux D" first="Daniel" last="Pissaloux">Daniel Pissaloux</name></author><author><name sortKey="Tomasic, Gorana" sort="Tomasic, Gorana" uniqKey="Tomasic G" first="Gorana" last="Tomasic">Gorana Tomasic</name></author><author><name sortKey="Cribier, Bernard" sort="Cribier, Bernard" uniqKey="Cribier B" first="Bernard" last="Cribier">Bernard Cribier</name></author><author><name sortKey="De La Fouchardiere, Arnaud" sort="De La Fouchardiere, Arnaud" uniqKey="De La Fouchardiere A" first="Arnaud" last="De La Fouchardière">Arnaud De La Fouchardière</name></author></analytic><series><title level="j">The American Journal of dermatopathology</title><idno type="eISSN">1533-0311</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biomarkers, Tumor (analysis)</term><term>Biomarkers, Tumor (genetics)</term><term>Biopsy</term><term>Comparative Genomic Hybridization</term><term>DNA Mutational Analysis</term><term>Fatal Outcome</term><term>GTP Phosphohydrolases (genetics)</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Melanins (analysis)</term><term>Melanocytes (chemistry)</term><term>Melanocytes (pathology)</term><term>Melanoma (chemistry)</term><term>Melanoma (genetics)</term><term>Melanoma (secondary)</term><term>Membrane Proteins (genetics)</term><term>Middle Aged</term><term>Mutation</term><term>Neoplasms, Adnexal and Skin Appendage (chemistry)</term><term>Neoplasms, Adnexal and Skin Appendage (genetics)</term><term>Neoplasms, Adnexal and Skin Appendage (pathology)</term><term>Neoplasms, Adnexal and Skin Appendage (surgery)</term><term>Skin Neoplasms (chemistry)</term><term>Skin Neoplasms (genetics)</term><term>Skin Neoplasms (pathology)</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers, Tumor</term><term>Melanins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Biomarkers, Tumor</term><term>GTP Phosphohydrolases</term><term>Membrane Proteins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Melanocytes</term><term>Melanoma</term><term>Neoplasms, Adnexal and Skin Appendage</term><term>Skin Neoplasms</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Melanoma</term><term>Neoplasms, Adnexal and Skin Appendage</term><term>Skin Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Melanocytes</term><term>Neoplasms, Adnexal and Skin Appendage</term><term>Skin Neoplasms</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Melanoma</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Neoplasms, Adnexal and Skin Appendage</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biopsy</term><term>Comparative Genomic Hybridization</term><term>DNA Mutational Analysis</term><term>Fatal Outcome</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term><term>Mutation</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Trichoblastoma is a benign cutaneous adnexal tumor, composed mostly of follicular germinative cells. Its pigmented variant is colonized by numerous dendritic melanocytes. So far, only one case in the literature describes a combination of trichoblastoma and melanoma. We report the case of a 62-year-old man who had a slow-growing mass of the left flank present since childhood. This 8-cm mass was surgically removed when it became ulcerated and associated with axillary lymph nodes. Histologically, this tumor was strictly dermal and composed of 2 intermingled components. Large sheets of atypical, proliferating epithelioid cells predominated. Dispersed solid nests or cribriform epithelial islets encased in fibrous tissue were also seen. Some nests displayed a massive colonization by pigmented dendritic melanocytes. On immunohistochemical staining, the sheets of atypical cells expressed focally but strongly S100 protein, MelanA, HMB45, and MiTF. Epithelial structures diffusely expressed pancytokeratin AE1/AE3, KL1, and pleckstrin homology-like domain, family A, member 1. Based on these results, we diagnosed an intradermal melanoma, possibly developed from dendritic melanocytes colonizing a giant pigmented trichoblastoma. Direct sequencing of the melanoma revealed a rarely described NRAS mutation c.34G>T (G12C). Array comparative genomic hybridization displayed a complex profile somewhat divergent from standard melanoma profiles. The patient died of widespread metastatic disease 8 months after initial diagnosis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24335517</PMID><DateCreated><Year>2014</Year><Month>07</Month><Day>24</Day></DateCreated><DateCompleted><Year>2015</Year><Month>04</Month><Day>06</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1533-0311</ISSN><JournalIssue CitedMedium="Internet"><Volume>36</Volume><Issue>8</Issue><PubDate><Year>2014</Year><Month>Aug</Month></PubDate></JournalIssue><Title>The American Journal of dermatopathology</Title><ISOAbbreviation>Am J Dermatopathol</ISOAbbreviation></Journal><ArticleTitle>Melanoma arising from a long-standing pigmented trichoblastoma: clinicopathologic study with complementary aCGH/mutational analysis.</ArticleTitle><Pagination><MedlinePgn>e146-51</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/DAD.0000000000000034</ELocationID><Abstract><AbstractText>Trichoblastoma is a benign cutaneous adnexal tumor, composed mostly of follicular germinative cells. Its pigmented variant is colonized by numerous dendritic melanocytes. So far, only one case in the literature describes a combination of trichoblastoma and melanoma. We report the case of a 62-year-old man who had a slow-growing mass of the left flank present since childhood. This 8-cm mass was surgically removed when it became ulcerated and associated with axillary lymph nodes. Histologically, this tumor was strictly dermal and composed of 2 intermingled components. Large sheets of atypical, proliferating epithelioid cells predominated. Dispersed solid nests or cribriform epithelial islets encased in fibrous tissue were also seen. Some nests displayed a massive colonization by pigmented dendritic melanocytes. On immunohistochemical staining, the sheets of atypical cells expressed focally but strongly S100 protein, MelanA, HMB45, and MiTF. Epithelial structures diffusely expressed pancytokeratin AE1/AE3, KL1, and pleckstrin homology-like domain, family A, member 1. Based on these results, we diagnosed an intradermal melanoma, possibly developed from dendritic melanocytes colonizing a giant pigmented trichoblastoma. Direct sequencing of the melanoma revealed a rarely described NRAS mutation c.34G>T (G12C). Array comparative genomic hybridization displayed a complex profile somewhat divergent from standard melanoma profiles. The patient died of widespread metastatic disease 8 months after initial diagnosis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Benaïm</LastName><ForeName>Gilles</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>*Département de Biopathologie, Centre Léon Bérard, Lyon, France; †Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, Australia; ‡Northern Translational Cancer Research Unit, Sydney Medical School, University of Sydney, Sydney, Australia; §Laboratoire de Pathologie, St Savine, France; ¶Services de Dermatologie, and ‖Pathologie, Institut Gustave Roussy, Villejuif, France; and **Service de Dermatologie, Hôpitaux de Strasbourg, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castillo</LastName><ForeName>Christine</ForeName><Initials>C</Initials></Author><Author 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UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Dermatopathol</MedlineTA><NlmUniqueID>7911005</NlmUniqueID><ISSNLinking>0193-1091</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014408">Biomarkers, Tumor</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008543">Melanins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008565">Membrane Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.1.-</RegistryNumber><NameOfSubstance UI="D020558">GTP Phosphohydrolases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.1.-</RegistryNumber><NameOfSubstance UI="C579846">NRAS protein, human</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D014408" MajorTopicYN="N">Biomarkers, Tumor</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001706" MajorTopicYN="N">Biopsy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055028" MajorTopicYN="Y">Comparative Genomic Hybridization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004252" MajorTopicYN="Y">DNA Mutational Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017809" MajorTopicYN="N">Fatal Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020558" MajorTopicYN="N">GTP Phosphohydrolases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008543" MajorTopicYN="N">Melanins</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008544" MajorTopicYN="N">Melanocytes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008545" MajorTopicYN="N">Melanoma</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000556" MajorTopicYN="N">secondary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008565" MajorTopicYN="N">Membrane Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018294" MajorTopicYN="N">Neoplasms, Adnexal and Skin Appendage</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012878" MajorTopicYN="N">Skin Neoplasms</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>12</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>12</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>4</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24335517</ArticleId><ArticleId IdType="doi">10.1097/DAD.0000000000000034</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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