Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes-proposal from the International/European LeukemiaNet Working Group for Flow Cytometry in MDS.
Identifieur interne : 003514 ( PubMed/Corpus ); précédent : 003513; suivant : 003515Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes-proposal from the International/European LeukemiaNet Working Group for Flow Cytometry in MDS.
Auteurs : A. Porwit ; A A Van De Loosdrecht ; P. Bettelheim ; L Eidenschink Brodersen ; K. Burbury ; E. Cremers ; M G Della Porta ; R. Ireland ; U. Johansson ; S. Matarraz ; K. Ogata ; A. Orfao ; F. Preijers ; K. Psarra ; D. Subirá ; P. Valent ; V H J. Van Der Velden ; D. Wells ; T M Westers ; W. Kern ; M C BénéSource :
- Leukemia [ 1476-5551 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- geographic : Europe.
- classification : Myelodysplastic Syndromes.
- diagnosis : Myelodysplastic Syndromes.
- methods : Flow Cytometry.
- Guidelines as Topic, Humans, World Health Organization.
Abstract
Definite progress has been made in the exploration of myelodysplastic syndromes (MDS) by flow cytometry (FCM) since the publication of the World Health Organization 2008 classification of myeloid neoplasms. An international working party initiated within the European LeukemiaNet and extended to include members from Australia, Canada, Japan, Taiwan and the United States has, through several workshops, developed and subsequently published consensus recommendations. The latter deal with preanalytical precautions, and propose small and large panels, which allow evaluating immunophenotypic anomalies and calculating myelodysplasia scores. The current paper provides guidelines that strongly recommend the integration of FCM data with other diagnostic tools in the diagnostic work-up of MDS.
DOI: 10.1038/leu.2014.191
PubMed: 24919805
Links to Exploration step
pubmed:24919805Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes-proposal from the International/European LeukemiaNet Working Group for Flow Cytometry in MDS.</title><author><name sortKey="Porwit, A" sort="Porwit, A" uniqKey="Porwit A" first="A" last="Porwit">A. Porwit</name><affiliation><nlm:affiliation>Department of Pathobiology and Laboratory Medicine, University of Toronto, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Van De Loosdrecht, A A" sort="Van De Loosdrecht, A A" uniqKey="Van De Loosdrecht A" first="A A" last="Van De Loosdrecht">A A Van De Loosdrecht</name><affiliation><nlm:affiliation>Department of Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Bettelheim, P" sort="Bettelheim, P" uniqKey="Bettelheim P" first="P" last="Bettelheim">P. Bettelheim</name><affiliation><nlm:affiliation>First Medical Department, Elisabethinen Hospital, Linz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Brodersen, L Eidenschink" sort="Brodersen, L Eidenschink" uniqKey="Brodersen L" first="L Eidenschink" last="Brodersen">L Eidenschink Brodersen</name><affiliation><nlm:affiliation>HematoLogics, Inc., Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Burbury, K" sort="Burbury, K" uniqKey="Burbury K" first="K" last="Burbury">K. Burbury</name><affiliation><nlm:affiliation>Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cremers, E" sort="Cremers, E" uniqKey="Cremers E" first="E" last="Cremers">E. Cremers</name><affiliation><nlm:affiliation>Department of Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Della Porta, M G" sort="Della Porta, M G" uniqKey="Della Porta M" first="M G" last="Della Porta">M G Della Porta</name><affiliation><nlm:affiliation>Department of Hematology and Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, and University of Pavia, Pavia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ireland, R" sort="Ireland, R" uniqKey="Ireland R" first="R" last="Ireland">R. Ireland</name><affiliation><nlm:affiliation>King's College Hospital, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Johansson, U" sort="Johansson, U" uniqKey="Johansson U" first="U" last="Johansson">U. Johansson</name><affiliation><nlm:affiliation>University Hospitals, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Matarraz, S" sort="Matarraz, S" uniqKey="Matarraz S" first="S" last="Matarraz">S. Matarraz</name><affiliation><nlm:affiliation>Servicio Central de Citometría, Centro de Investigación del Cáncer, Instituto de Biologia Celular y Molecular del Cáncer CSIC/USAL/IBSAL) and Department of Medicine, Universidad de Salamanca, Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ogata, K" sort="Ogata, K" uniqKey="Ogata K" first="K" last="Ogata">K. Ogata</name><affiliation><nlm:affiliation>Metropolitan Research Center for Blood Disorders MRC JAPAN, Midorigaoka, Chofu, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Orfao, A" sort="Orfao, A" uniqKey="Orfao A" first="A" last="Orfao">A. Orfao</name><affiliation><nlm:affiliation>Servicio Central de Citometría, Centro de Investigación del Cáncer, Instituto de Biologia Celular y Molecular del Cáncer CSIC/USAL/IBSAL) and Department of Medicine, Universidad de Salamanca, Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Preijers, F" sort="Preijers, F" uniqKey="Preijers F" first="F" last="Preijers">F. Preijers</name><affiliation><nlm:affiliation>Department of Hematology, St Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Psarra, K" sort="Psarra, K" uniqKey="Psarra K" first="K" last="Psarra">K. Psarra</name><affiliation><nlm:affiliation>Department of Immunology-Histocompatibility, Evangelismos Hospital, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Subira, D" sort="Subira, D" uniqKey="Subira D" first="D" last="Subirá">D. Subirá</name><affiliation><nlm:affiliation>Department of Hematology, Hospital Universitario de Guadalajara, Guadalajara, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Valent, P" sort="Valent, P" uniqKey="Valent P" first="P" last="Valent">P. Valent</name><affiliation><nlm:affiliation>Department of Internal Medicine I, Division of Hematology and Hemostaseology and Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Velden, V H J" sort="Van Der Velden, V H J" uniqKey="Van Der Velden V" first="V H J" last="Van Der Velden">V H J. Van Der Velden</name><affiliation><nlm:affiliation>Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wells, D" sort="Wells, D" uniqKey="Wells D" first="D" last="Wells">D. Wells</name><affiliation><nlm:affiliation>HematoLogics, Inc., Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Westers, T M" sort="Westers, T M" uniqKey="Westers T" first="T M" last="Westers">T M Westers</name><affiliation><nlm:affiliation>Department of Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Kern, W" sort="Kern, W" uniqKey="Kern W" first="W" last="Kern">W. Kern</name><affiliation><nlm:affiliation>MLL Munich Leukemia Laboratory, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bene, M C" sort="Bene, M C" uniqKey="Bene M" first="M C" last="Béné">M C Béné</name><affiliation><nlm:affiliation>Service d'Hématologie Biologique, CHU de Nantes, Nantes, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24919805</idno><idno type="pmid">24919805</idno><idno type="doi">10.1038/leu.2014.191</idno><idno type="wicri:Area/PubMed/Corpus">003514</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003514</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes-proposal from the International/European LeukemiaNet Working Group for Flow Cytometry in MDS.</title><author><name sortKey="Porwit, A" sort="Porwit, A" uniqKey="Porwit A" first="A" last="Porwit">A. Porwit</name><affiliation><nlm:affiliation>Department of Pathobiology and Laboratory Medicine, University of Toronto, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Van De Loosdrecht, A A" sort="Van De Loosdrecht, A A" uniqKey="Van De Loosdrecht A" first="A A" last="Van De Loosdrecht">A A Van De Loosdrecht</name><affiliation><nlm:affiliation>Department of Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Bettelheim, P" sort="Bettelheim, P" uniqKey="Bettelheim P" first="P" last="Bettelheim">P. Bettelheim</name><affiliation><nlm:affiliation>First Medical Department, Elisabethinen Hospital, Linz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Brodersen, L Eidenschink" sort="Brodersen, L Eidenschink" uniqKey="Brodersen L" first="L Eidenschink" last="Brodersen">L Eidenschink Brodersen</name><affiliation><nlm:affiliation>HematoLogics, Inc., Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Burbury, K" sort="Burbury, K" uniqKey="Burbury K" first="K" last="Burbury">K. Burbury</name><affiliation><nlm:affiliation>Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cremers, E" sort="Cremers, E" uniqKey="Cremers E" first="E" last="Cremers">E. Cremers</name><affiliation><nlm:affiliation>Department of Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Della Porta, M G" sort="Della Porta, M G" uniqKey="Della Porta M" first="M G" last="Della Porta">M G Della Porta</name><affiliation><nlm:affiliation>Department of Hematology and Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, and University of Pavia, Pavia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ireland, R" sort="Ireland, R" uniqKey="Ireland R" first="R" last="Ireland">R. Ireland</name><affiliation><nlm:affiliation>King's College Hospital, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Johansson, U" sort="Johansson, U" uniqKey="Johansson U" first="U" last="Johansson">U. Johansson</name><affiliation><nlm:affiliation>University Hospitals, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Matarraz, S" sort="Matarraz, S" uniqKey="Matarraz S" first="S" last="Matarraz">S. Matarraz</name><affiliation><nlm:affiliation>Servicio Central de Citometría, Centro de Investigación del Cáncer, Instituto de Biologia Celular y Molecular del Cáncer CSIC/USAL/IBSAL) and Department of Medicine, Universidad de Salamanca, Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ogata, K" sort="Ogata, K" uniqKey="Ogata K" first="K" last="Ogata">K. Ogata</name><affiliation><nlm:affiliation>Metropolitan Research Center for Blood Disorders MRC JAPAN, Midorigaoka, Chofu, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Orfao, A" sort="Orfao, A" uniqKey="Orfao A" first="A" last="Orfao">A. Orfao</name><affiliation><nlm:affiliation>Servicio Central de Citometría, Centro de Investigación del Cáncer, Instituto de Biologia Celular y Molecular del Cáncer CSIC/USAL/IBSAL) and Department of Medicine, Universidad de Salamanca, Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Preijers, F" sort="Preijers, F" uniqKey="Preijers F" first="F" last="Preijers">F. Preijers</name><affiliation><nlm:affiliation>Department of Hematology, St Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Psarra, K" sort="Psarra, K" uniqKey="Psarra K" first="K" last="Psarra">K. Psarra</name><affiliation><nlm:affiliation>Department of Immunology-Histocompatibility, Evangelismos Hospital, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Subira, D" sort="Subira, D" uniqKey="Subira D" first="D" last="Subirá">D. Subirá</name><affiliation><nlm:affiliation>Department of Hematology, Hospital Universitario de Guadalajara, Guadalajara, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Valent, P" sort="Valent, P" uniqKey="Valent P" first="P" last="Valent">P. Valent</name><affiliation><nlm:affiliation>Department of Internal Medicine I, Division of Hematology and Hemostaseology and Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Velden, V H J" sort="Van Der Velden, V H J" uniqKey="Van Der Velden V" first="V H J" last="Van Der Velden">V H J. Van Der Velden</name><affiliation><nlm:affiliation>Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wells, D" sort="Wells, D" uniqKey="Wells D" first="D" last="Wells">D. Wells</name><affiliation><nlm:affiliation>HematoLogics, Inc., Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Westers, T M" sort="Westers, T M" uniqKey="Westers T" first="T M" last="Westers">T M Westers</name><affiliation><nlm:affiliation>Department of Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Kern, W" sort="Kern, W" uniqKey="Kern W" first="W" last="Kern">W. Kern</name><affiliation><nlm:affiliation>MLL Munich Leukemia Laboratory, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bene, M C" sort="Bene, M C" uniqKey="Bene M" first="M C" last="Béné">M C Béné</name><affiliation><nlm:affiliation>Service d'Hématologie Biologique, CHU de Nantes, Nantes, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Leukemia</title><idno type="eISSN">1476-5551</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Europe</term><term>Flow Cytometry (methods)</term><term>Guidelines as Topic</term><term>Humans</term><term>Myelodysplastic Syndromes (classification)</term><term>Myelodysplastic Syndromes (diagnosis)</term><term>World Health Organization</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Europe</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Myelodysplastic Syndromes</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Myelodysplastic Syndromes</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Flow Cytometry</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Guidelines as Topic</term><term>Humans</term><term>World Health Organization</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Definite progress has been made in the exploration of myelodysplastic syndromes (MDS) by flow cytometry (FCM) since the publication of the World Health Organization 2008 classification of myeloid neoplasms. An international working party initiated within the European LeukemiaNet and extended to include members from Australia, Canada, Japan, Taiwan and the United States has, through several workshops, developed and subsequently published consensus recommendations. The latter deal with preanalytical precautions, and propose small and large panels, which allow evaluating immunophenotypic anomalies and calculating myelodysplasia scores. The current paper provides guidelines that strongly recommend the integration of FCM data with other diagnostic tools in the diagnostic work-up of MDS.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24919805</PMID><DateCreated><Year>2014</Year><Month>09</Month><Day>03</Day></DateCreated><DateCompleted><Year>2014</Year><Month>10</Month><Day>31</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-5551</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>9</Issue><PubDate><Year>2014</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Leukemia</Title><ISOAbbreviation>Leukemia</ISOAbbreviation></Journal><ArticleTitle>Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes-proposal from the International/European LeukemiaNet Working Group for Flow Cytometry in MDS.</ArticleTitle><Pagination><MedlinePgn>1793-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/leu.2014.191</ELocationID><Abstract><AbstractText>Definite progress has been made in the exploration of myelodysplastic syndromes (MDS) by flow cytometry (FCM) since the publication of the World Health Organization 2008 classification of myeloid neoplasms. An international working party initiated within the European LeukemiaNet and extended to include members from Australia, Canada, Japan, Taiwan and the United States has, through several workshops, developed and subsequently published consensus recommendations. The latter deal with preanalytical precautions, and propose small and large panels, which allow evaluating immunophenotypic anomalies and calculating myelodysplasia scores. The current paper provides guidelines that strongly recommend the integration of FCM data with other diagnostic tools in the diagnostic work-up of MDS.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Porwit</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pathobiology and Laboratory Medicine, University of Toronto, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van de Loosdrecht</LastName><ForeName>A A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Department of Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bettelheim</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>First Medical Department, Elisabethinen Hospital, Linz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brodersen</LastName><ForeName>L Eidenschink</ForeName><Initials>LE</Initials><AffiliationInfo><Affiliation>HematoLogics, Inc., Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burbury</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cremers</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Della Porta</LastName><ForeName>M G</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Department of Hematology and Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, and University of Pavia, Pavia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ireland</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>King's College Hospital, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johansson</LastName><ForeName>U</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>University Hospitals, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matarraz</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Servicio Central de Citometría, Centro de Investigación del Cáncer, Instituto de Biologia Celular y Molecular del Cáncer CSIC/USAL/IBSAL) and Department of Medicine, Universidad de Salamanca, Salamanca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ogata</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Metropolitan Research Center for Blood Disorders MRC JAPAN, Midorigaoka, Chofu, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Orfao</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Servicio Central de Citometría, Centro de Investigación del Cáncer, Instituto de Biologia Celular y Molecular del Cáncer CSIC/USAL/IBSAL) and Department of Medicine, Universidad de Salamanca, Salamanca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Preijers</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Hematology, St Radboud University Medical Center, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Psarra</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Immunology-Histocompatibility, Evangelismos Hospital, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Subirá</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Hematology, Hospital Universitario de Guadalajara, Guadalajara, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valent</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine I, Division of Hematology and Hemostaseology and Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Velden</LastName><ForeName>V H J</ForeName><Initials>VH</Initials><AffiliationInfo><Affiliation>Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wells</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>HematoLogics, Inc., Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Westers</LastName><ForeName>T M</ForeName><Initials>TM</Initials><AffiliationInfo><Affiliation>Department of Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kern</LastName><ForeName>W</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>MLL Munich Leukemia Laboratory, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Béné</LastName><ForeName>M C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Service d'Hématologie Biologique, CHU de Nantes, Nantes, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>06</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Leukemia</MedlineTA><NlmUniqueID>8704895</NlmUniqueID><ISSNLinking>0887-6924</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Leuk Res. 2012 Oct;36(10):1229-36</RefSource><PMID Version="1">22682984</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cytometry B Clin Cytom. 2013 May;84(3):194-7</RefSource><PMID Version="1">23283847</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Haematologica. 2009 Aug;94(8):1124-34</RefSource><PMID 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MajorTopicYN="N">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014944" MajorTopicYN="N">World Health Organization</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>11</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>04</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>05</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>6</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>6</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>11</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId 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