The staphylococcal toxins γ-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors.
Identifieur interne : 003332 ( PubMed/Corpus ); précédent : 003331; suivant : 003333The staphylococcal toxins γ-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors.
Auteurs : András N. Spaan ; Manouk Vrieling ; Pierre Wallet ; Cédric Badiou ; Tamara Reyes-Robles ; Elizabeth A. Ohneck ; Yvonne Benito ; Carla J C. De Haas ; Christopher J. Day ; Michael P. Jennings ; Gérard Lina ; François Vandenesch ; Kok P M. Van Kessel ; Victor J. Torres ; Jos A G. Van Strijp ; Thomas HenrySource :
- Nature communications [ 2041-1723 ] ; 2014.
English descriptors
- KwdEn :
- Animals, Bacterial Proteins (physiology), Bacterial Toxins, Cells, Cultured, Disease Models, Animal, Female, Hemolysin Proteins (physiology), Humans, Macrophages (microbiology), Macrophages (pathology), Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Peritonitis (microbiology), Peritonitis (pathology), Peritonitis (physiopathology), Phagocytes (microbiology), Phagocytes (pathology), Receptors, CCR2 (deficiency), Receptors, CCR2 (genetics), Receptors, CCR2 (physiology), Receptors, Chemokine (physiology), Receptors, Complement (physiology), Receptors, Interleukin-8A (physiology), Receptors, Interleukin-8B (physiology), Staphylococcal Infections (pathology), Staphylococcal Infections (physiopathology), Staphylococcus aureus.
- MESH :
- chemical , deficiency : Receptors, CCR2.
- chemical , genetics : Receptors, CCR2.
- chemical , physiology : Bacterial Proteins, Hemolysin Proteins, Receptors, CCR2, Receptors, Chemokine, Receptors, Complement, Receptors, Interleukin-8A, Receptors, Interleukin-8B.
- microbiology : Macrophages, Peritonitis, Phagocytes.
- pathology : Macrophages, Peritonitis, Phagocytes, Staphylococcal Infections.
- physiopathology : Peritonitis, Staphylococcal Infections.
- Animals, Bacterial Toxins, Cells, Cultured, Disease Models, Animal, Female, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Staphylococcus aureus.
Abstract
Evasion of the host phagocyte response by Staphylococcus aureus is crucial to successful infection with the pathogen. γ-haemolysin AB and CB (HlgAB, HlgCB) are bicomponent pore-forming toxins present in almost all human S. aureus isolates. Cellular tropism and contribution of the toxins to S. aureus pathophysiology are poorly understood. Here we identify the chemokine receptors CXCR1, CXCR2 and CCR2 as targets for HlgAB, and the complement receptors C5aR and C5L2 as targets for HlgCB. The receptor expression patterns allow the toxins to efficiently and differentially target phagocytic cells. Murine neutrophils are resistant to HlgAB and HlgCB. CCR2 is the sole murine receptor orthologue compatible with γ-haemolysin. In a murine peritonitis model, HlgAB contributes to S. aureus bacteremia in a CCR2-dependent manner. HlgAB-mediated targeting of CCR2(+) cells highlights the involvement of inflammatory macrophages during S. aureus infection. Functional quantification identifies HlgAB and HlgCB as major secreted staphylococcal leukocidins.
DOI: 10.1038/ncomms6438
PubMed: 25384670
Links to Exploration step
pubmed:25384670Le document en format XML
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Spaan</name><affiliation><nlm:affiliation>1] Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands [2] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [3] Inserm, U1111, 69007 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vrieling, Manouk" sort="Vrieling, Manouk" uniqKey="Vrieling M" first="Manouk" last="Vrieling">Manouk Vrieling</name><affiliation><nlm:affiliation>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wallet, Pierre" sort="Wallet, Pierre" uniqKey="Wallet P" first="Pierre" last="Wallet">Pierre Wallet</name><affiliation><nlm:affiliation>1] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [2] Inserm, U1111, 69007 Lyon, France [3] CNRS, UMR5308, 69007 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Badiou, Cedric" sort="Badiou, Cedric" uniqKey="Badiou C" first="Cédric" last="Badiou">Cédric Badiou</name><affiliation><nlm:affiliation>1] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [2] Inserm, U1111, 69007 Lyon, France [3] CNRS, UMR5308, 69007 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Reyes Robles, Tamara" sort="Reyes Robles, Tamara" uniqKey="Reyes Robles T" first="Tamara" last="Reyes-Robles">Tamara Reyes-Robles</name><affiliation><nlm:affiliation>Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ohneck, Elizabeth A" sort="Ohneck, Elizabeth A" uniqKey="Ohneck E" first="Elizabeth A" last="Ohneck">Elizabeth A. 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De Haas</name><affiliation><nlm:affiliation>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Day, Christopher J" sort="Day, Christopher J" uniqKey="Day C" first="Christopher J" last="Day">Christopher J. Day</name><affiliation><nlm:affiliation>Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Jennings, Michael P" sort="Jennings, Michael P" uniqKey="Jennings M" first="Michael P" last="Jennings">Michael P. Jennings</name><affiliation><nlm:affiliation>Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lina, Gerard" sort="Lina, Gerard" uniqKey="Lina G" first="Gérard" last="Lina">Gérard Lina</name><affiliation><nlm:affiliation>1] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [2] Inserm, U1111, 69007 Lyon, France [3] CNRS, UMR5308, 69007 Lyon, France [4] Centre National de Référence des Staphylocoques, Hospices Civils de Lyon, 69007 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vandenesch, Francois" sort="Vandenesch, Francois" uniqKey="Vandenesch F" first="François" last="Vandenesch">François Vandenesch</name><affiliation><nlm:affiliation>1] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [2] Inserm, U1111, 69007 Lyon, France [3] CNRS, UMR5308, 69007 Lyon, France [4] Centre National de Référence des Staphylocoques, Hospices Civils de Lyon, 69007 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Van Kessel, Kok P M" sort="Van Kessel, Kok P M" uniqKey="Van Kessel K" first="Kok P M" last="Van Kessel">Kok P M. Van Kessel</name><affiliation><nlm:affiliation>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Torres, Victor J" sort="Torres, Victor J" uniqKey="Torres V" first="Victor J" last="Torres">Victor J. Torres</name><affiliation><nlm:affiliation>Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Van Strijp, Jos A G" sort="Van Strijp, Jos A G" uniqKey="Van Strijp J" first="Jos A G" last="Van Strijp">Jos A G. Van Strijp</name><affiliation><nlm:affiliation>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Henry, Thomas" sort="Henry, Thomas" uniqKey="Henry T" first="Thomas" last="Henry">Thomas Henry</name><affiliation><nlm:affiliation>1] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [2] Inserm, U1111, 69007 Lyon, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25384670</idno><idno type="pmid">25384670</idno><idno type="doi">10.1038/ncomms6438</idno><idno type="wicri:Area/PubMed/Corpus">003332</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003332</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The staphylococcal toxins γ-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors.</title><author><name sortKey="Spaan, Andras N" sort="Spaan, Andras N" uniqKey="Spaan A" first="András N" last="Spaan">András N. Spaan</name><affiliation><nlm:affiliation>1] Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands [2] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [3] Inserm, U1111, 69007 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vrieling, Manouk" sort="Vrieling, Manouk" uniqKey="Vrieling M" first="Manouk" last="Vrieling">Manouk Vrieling</name><affiliation><nlm:affiliation>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wallet, Pierre" sort="Wallet, Pierre" uniqKey="Wallet P" first="Pierre" last="Wallet">Pierre Wallet</name><affiliation><nlm:affiliation>1] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [2] Inserm, U1111, 69007 Lyon, France [3] CNRS, UMR5308, 69007 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Badiou, Cedric" sort="Badiou, Cedric" uniqKey="Badiou C" first="Cédric" last="Badiou">Cédric Badiou</name><affiliation><nlm:affiliation>1] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [2] Inserm, U1111, 69007 Lyon, France [3] CNRS, UMR5308, 69007 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Reyes Robles, Tamara" sort="Reyes Robles, Tamara" uniqKey="Reyes Robles T" first="Tamara" last="Reyes-Robles">Tamara Reyes-Robles</name><affiliation><nlm:affiliation>Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ohneck, Elizabeth A" sort="Ohneck, Elizabeth A" uniqKey="Ohneck E" first="Elizabeth A" last="Ohneck">Elizabeth A. Ohneck</name><affiliation><nlm:affiliation>Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Benito, Yvonne" sort="Benito, Yvonne" uniqKey="Benito Y" first="Yvonne" last="Benito">Yvonne Benito</name><affiliation><nlm:affiliation>1] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [2] Inserm, U1111, 69007 Lyon, France [3] CNRS, UMR5308, 69007 Lyon, France [4] Centre National de Référence des Staphylocoques, Hospices Civils de Lyon, 69007 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="De Haas, Carla J C" sort="De Haas, Carla J C" uniqKey="De Haas C" first="Carla J C" last="De Haas">Carla J C. De Haas</name><affiliation><nlm:affiliation>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Day, Christopher J" sort="Day, Christopher J" uniqKey="Day C" first="Christopher J" last="Day">Christopher J. Day</name><affiliation><nlm:affiliation>Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Jennings, Michael P" sort="Jennings, Michael P" uniqKey="Jennings M" first="Michael P" last="Jennings">Michael P. Jennings</name><affiliation><nlm:affiliation>Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lina, Gerard" sort="Lina, Gerard" uniqKey="Lina G" first="Gérard" last="Lina">Gérard Lina</name><affiliation><nlm:affiliation>1] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [2] Inserm, U1111, 69007 Lyon, France [3] CNRS, UMR5308, 69007 Lyon, France [4] Centre National de Référence des Staphylocoques, Hospices Civils de Lyon, 69007 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vandenesch, Francois" sort="Vandenesch, Francois" uniqKey="Vandenesch F" first="François" last="Vandenesch">François Vandenesch</name><affiliation><nlm:affiliation>1] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [2] Inserm, U1111, 69007 Lyon, France [3] CNRS, UMR5308, 69007 Lyon, France [4] Centre National de Référence des Staphylocoques, Hospices Civils de Lyon, 69007 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Van Kessel, Kok P M" sort="Van Kessel, Kok P M" uniqKey="Van Kessel K" first="Kok P M" last="Van Kessel">Kok P M. Van Kessel</name><affiliation><nlm:affiliation>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Torres, Victor J" sort="Torres, Victor J" uniqKey="Torres V" first="Victor J" last="Torres">Victor J. Torres</name><affiliation><nlm:affiliation>Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Van Strijp, Jos A G" sort="Van Strijp, Jos A G" uniqKey="Van Strijp J" first="Jos A G" last="Van Strijp">Jos A G. Van Strijp</name><affiliation><nlm:affiliation>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Henry, Thomas" sort="Henry, Thomas" uniqKey="Henry T" first="Thomas" last="Henry">Thomas Henry</name><affiliation><nlm:affiliation>1] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [2] Inserm, U1111, 69007 Lyon, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Nature communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bacterial Proteins (physiology)</term><term>Bacterial Toxins</term><term>Cells, Cultured</term><term>Disease Models, Animal</term><term>Female</term><term>Hemolysin Proteins (physiology)</term><term>Humans</term><term>Macrophages (microbiology)</term><term>Macrophages (pathology)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Peritonitis (microbiology)</term><term>Peritonitis (pathology)</term><term>Peritonitis (physiopathology)</term><term>Phagocytes (microbiology)</term><term>Phagocytes (pathology)</term><term>Receptors, CCR2 (deficiency)</term><term>Receptors, CCR2 (genetics)</term><term>Receptors, CCR2 (physiology)</term><term>Receptors, Chemokine (physiology)</term><term>Receptors, Complement (physiology)</term><term>Receptors, Interleukin-8A (physiology)</term><term>Receptors, Interleukin-8B (physiology)</term><term>Staphylococcal Infections (pathology)</term><term>Staphylococcal Infections (physiopathology)</term><term>Staphylococcus aureus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Receptors, CCR2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, CCR2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Bacterial Proteins</term><term>Hemolysin Proteins</term><term>Receptors, CCR2</term><term>Receptors, Chemokine</term><term>Receptors, Complement</term><term>Receptors, Interleukin-8A</term><term>Receptors, Interleukin-8B</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Macrophages</term><term>Peritonitis</term><term>Phagocytes</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Macrophages</term><term>Peritonitis</term><term>Phagocytes</term><term>Staphylococcal Infections</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Peritonitis</term><term>Staphylococcal Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Bacterial Toxins</term><term>Cells, Cultured</term><term>Disease Models, Animal</term><term>Female</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Staphylococcus aureus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Evasion of the host phagocyte response by Staphylococcus aureus is crucial to successful infection with the pathogen. γ-haemolysin AB and CB (HlgAB, HlgCB) are bicomponent pore-forming toxins present in almost all human S. aureus isolates. Cellular tropism and contribution of the toxins to S. aureus pathophysiology are poorly understood. Here we identify the chemokine receptors CXCR1, CXCR2 and CCR2 as targets for HlgAB, and the complement receptors C5aR and C5L2 as targets for HlgCB. The receptor expression patterns allow the toxins to efficiently and differentially target phagocytic cells. Murine neutrophils are resistant to HlgAB and HlgCB. CCR2 is the sole murine receptor orthologue compatible with γ-haemolysin. In a murine peritonitis model, HlgAB contributes to S. aureus bacteremia in a CCR2-dependent manner. HlgAB-mediated targeting of CCR2(+) cells highlights the involvement of inflammatory macrophages during S. aureus infection. Functional quantification identifies HlgAB and HlgCB as major secreted staphylococcal leukocidins.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25384670</PMID><DateCreated><Year>2014</Year><Month>11</Month><Day>11</Day></DateCreated><DateCompleted><Year>2016</Year><Month>02</Month><Day>22</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>03</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-1723</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><PubDate><Year>2014</Year><Month>Nov</Month><Day>11</Day></PubDate></JournalIssue><Title>Nature communications</Title><ISOAbbreviation>Nat Commun</ISOAbbreviation></Journal><ArticleTitle>The staphylococcal toxins γ-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors.</ArticleTitle><Pagination><MedlinePgn>5438</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/ncomms6438</ELocationID><Abstract><AbstractText>Evasion of the host phagocyte response by Staphylococcus aureus is crucial to successful infection with the pathogen. γ-haemolysin AB and CB (HlgAB, HlgCB) are bicomponent pore-forming toxins present in almost all human S. aureus isolates. Cellular tropism and contribution of the toxins to S. aureus pathophysiology are poorly understood. Here we identify the chemokine receptors CXCR1, CXCR2 and CCR2 as targets for HlgAB, and the complement receptors C5aR and C5L2 as targets for HlgCB. The receptor expression patterns allow the toxins to efficiently and differentially target phagocytic cells. Murine neutrophils are resistant to HlgAB and HlgCB. CCR2 is the sole murine receptor orthologue compatible with γ-haemolysin. In a murine peritonitis model, HlgAB contributes to S. aureus bacteremia in a CCR2-dependent manner. HlgAB-mediated targeting of CCR2(+) cells highlights the involvement of inflammatory macrophages during S. aureus infection. Functional quantification identifies HlgAB and HlgCB as major secreted staphylococcal leukocidins.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Spaan</LastName><ForeName>András N</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>1] Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands [2] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [3] Inserm, U1111, 69007 Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vrieling</LastName><ForeName>Manouk</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wallet</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>1] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [2] Inserm, U1111, 69007 Lyon, France [3] CNRS, UMR5308, 69007 Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Badiou</LastName><ForeName>Cédric</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>1] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [2] Inserm, U1111, 69007 Lyon, France [3] CNRS, UMR5308, 69007 Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reyes-Robles</LastName><ForeName>Tamara</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ohneck</LastName><ForeName>Elizabeth A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benito</LastName><ForeName>Yvonne</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>1] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [2] Inserm, U1111, 69007 Lyon, France [3] CNRS, UMR5308, 69007 Lyon, France [4] Centre National de Référence des Staphylocoques, Hospices Civils de Lyon, 69007 Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Haas</LastName><ForeName>Carla J C</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Day</LastName><ForeName>Christopher J</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jennings</LastName><ForeName>Michael P</ForeName><Initials>MP</Initials><AffiliationInfo><Affiliation>Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lina</LastName><ForeName>Gérard</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>1] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [2] Inserm, U1111, 69007 Lyon, France [3] CNRS, UMR5308, 69007 Lyon, France [4] Centre National de Référence des Staphylocoques, Hospices Civils de Lyon, 69007 Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vandenesch</LastName><ForeName>François</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>1] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [2] Inserm, U1111, 69007 Lyon, France [3] CNRS, UMR5308, 69007 Lyon, France [4] Centre National de Référence des Staphylocoques, Hospices Civils de Lyon, 69007 Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Kessel</LastName><ForeName>Kok P M</ForeName><Initials>KP</Initials><AffiliationInfo><Affiliation>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Torres</LastName><ForeName>Victor J</ForeName><Initials>VJ</Initials><AffiliationInfo><Affiliation>Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Strijp</LastName><ForeName>Jos A G</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Henry</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>1] CIRI, International Center for Infectiology Research, Université Lyon 1 and Ecole Normale Supérieure de Lyon, 69007 Lyon, France [2] Inserm, U1111, 69007 Lyon, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01-AI105129</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN272200700055C</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI105129</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN272200700055C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>F31 AI112290</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 AI007180</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32-AI007180</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>11</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat Commun</MedlineTA><NlmUniqueID>101528555</NlmUniqueID><ISSNLinking>2041-1723</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001426">Bacterial Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001427">Bacterial Toxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006460">Hemolysin Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054390">Receptors, CCR2</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019707">Receptors, Chemokine</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011951">Receptors, Complement</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D023062">Receptors, Interleukin-8A</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D023063">Receptors, Interleukin-8B</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C037956">gamma-hemolysin, Staphylococcus aureus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2005 Sep 15;175(6):3907-19</RefSource><PMID Version="1">16148137</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Mol Biol. 2005 Nov 4;353(4):859-72</RefSource><PMID Version="1">16213522</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Immunol. 2006 Mar;7(3):311-7</RefSource><PMID Version="1">16462739</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2006 Mar 4;367(9512):731-9</RefSource><PMID Version="1">16517273</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2007 Apr 20;282(16):11658-66</RefSource><PMID Version="1">17197447</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2004 Mar 1;199(5):687-95</RefSource><PMID Version="1">14993252</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Leukoc Biol. 1997 Mar;61(3):329-37</RefSource><PMID Version="1">9060456</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Med Microbiol. 1997 Jun;46(6):479-85</RefSource><PMID Version="1">9350200</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2013 Feb 14;494(7436):185-94</RefSource><PMID Version="1">23407534</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Immunol. 2013 Mar;13(3):159-75</RefSource><PMID Version="1">23435331</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>JAMA. 2013 Apr 3;309(13):1368-78</RefSource><PMID Version="1">23549582</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Microbiol. 2013 Feb;16(1):63-9</RefSource><PMID Version="1">23466211</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2013 May;81(5):1830-41</RefSource><PMID Version="1">23509138</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Host Microbe. 2013 May 15;13(5):584-94</RefSource><PMID Version="1">23684309</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10794-9</RefSource><PMID Version="1">23754403</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Microbiol. 2013;67:629-50</RefSource><PMID Version="1">23834243</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Genet Evol. 2013 Oct;19:7-14</RefSource><PMID Version="1">23792184</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Host Microbe. 2013 Oct 16;14(4):453-9</RefSource><PMID Version="1">24139401</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Microbiol. 2014 Jan;22(1):21-7</RefSource><PMID Version="1">24231517</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Pathog. 2014 Feb;10(2):e1003960</RefSource><PMID Version="1">24586164</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2014;9(3):e92094</RefSource><PMID Version="1">24643034</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2014 Apr 15;192(8):3858-67</RefSource><PMID Version="1">24639350</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Microbiol Mol Biol Rev. 2014 Jun;78(2):199-230</RefSource><PMID Version="1">24847020</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Microbiol. 2000 Mar;38(3):1008-15</RefSource><PMID Version="1">10698988</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2001 Apr;69(4):2390-5</RefSource><PMID Version="1">11254598</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Leukoc Biol. 2001 Apr;69(4):666-74</RefSource><PMID Version="1">11310855</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Bacteriol. 2004 Mar;186(5):1518-30</RefSource><PMID Version="1">14973027</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Diagn Microbiol Infect Dis. 2004 Jul;49(3):157-62</RefSource><PMID Version="1">15246504</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 1980 Aug;29(2):678-84</RefSource><PMID Version="1">7216434</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biosci Biotechnol Biochem. 1994 Mar;58(3):602-5</RefSource><PMID Version="1">7764698</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Med Microbiol. 1995 Apr;42(4):237-45</RefSource><PMID Version="1">7707330</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 1995 Oct;63(10):4121-9</RefSource><PMID Version="1">7558328</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Med Microbiol. 1997 Jun;46(6):486-94</RefSource><PMID Version="1">9350201</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 1997 Nov 17;186(10):1757-62</RefSource><PMID Version="1">9362535</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Microb Pathog. 1998 Apr;24(4):241-51</RefSource><PMID Version="1">9533895</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 1998 Aug 20;339(8):520-32</RefSource><PMID Version="1">9709046</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FEBS Lett. 1998 Oct 2;436(2):202-8</RefSource><PMID Version="1">9781679</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 1999 Mar;67(3):1045-9</RefSource><PMID Version="1">10024541</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem J. 1959 Oct;73:225-37</RefSource><PMID Version="1">13845859</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Pharmacol. 2007 Oct;152(4):429-48</RefSource><PMID Version="1">17603557</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2007 Dec;13(12):1510-4</RefSource><PMID Version="1">17994102</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2008;3(9):e3198</RefSource><PMID Version="1">18787708</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Membr Biol. 2009 Jan;227(1):13-24</RefSource><PMID Version="1">19067025</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5587-92</RefSource><PMID Version="1">20231457</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2010 May 1;375(9725):1557-68</RefSource><PMID Version="1">20206987</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Leukoc Biol. 2010 Jul;88(1):169-80</RefSource><PMID Version="1">20400676</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2010;5(7):e11634</RefSource><PMID Version="1">20661294</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Microbiol. 2011 Feb;79(3):814-25</RefSource><PMID Version="1">21255120</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2011;6(4):e18617</RefSource><PMID Version="1">21525981</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2011;6(8):e22864</RefSource><PMID Version="1">21850240</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Microbiol. 2012 Jan;83(2):423-35</RefSource><PMID Version="1">22142035</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Semin Immunopathol. 2012 Mar;34(2):237-59</RefSource><PMID Version="1">22080185</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Pathog. 2012;8(3):e1002606</RefSource><PMID Version="1">22457627</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunity. 2012 May 25;36(5):705-16</RefSource><PMID Version="1">22633458</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Microbiol. 2012 Jul;14(7):1019-36</RefSource><PMID Version="1">22329718</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2012 Aug;80(8):2894-904</RefSource><PMID Version="1">22665379</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Leukoc Biol. 2012 Aug;92(2):361-74</RefSource><PMID Version="1">22581932</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Cell Infect Microbiol. 2012;2:12</RefSource><PMID Version="1">22919604</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>EMBO J. 2012 Aug 29;31(17):3607-19</RefSource><PMID Version="1">22850671</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 2012 Oct;80(10):3721-32</RefSource><PMID Version="1">22802349</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2013 Jan 3;493(7430):51-5</RefSource><PMID Version="1">23235831</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" 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