ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis.
Identifieur interne : 003309 ( PubMed/Corpus ); précédent : 003308; suivant : 003310ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis.
Auteurs : Raquel Fucho ; Laura Martínez ; Anna Baulies ; Sandra Torres ; Nuria Tarrats ; Anna Fernandez ; Vicente Ribas ; Alma M. Astudillo ; Jesús Balsinde ; Pablo Garcia-Rovés ; Montserrat Elena ; Ina Bergheim ; Sophie Lotersztajn ; Christian Trautwein ; Hanna Appelqvist ; Adrienne W. Paton ; James C. Paton ; Mark J. Czaja ; Neil Kaplowitz ; Jose C. Fernandez-Checa ; Carmen García-RuizSource :
- Journal of hepatology [ 1600-0641 ] ; 2014.
English descriptors
- KwdEn :
- Amitriptyline (pharmacology), Animals, Autophagy (physiology), Ceramides (metabolism), Cholesterol (metabolism), Choline Deficiency (complications), Diet, High-Fat (adverse effects), Disease Models, Animal, Endoplasmic Reticulum Stress, Humans, Liver (metabolism), Liver (pathology), Lysosomes (metabolism), Methionine (deficiency), Mice, Mice, Inbred C57BL, Mice, Knockout, Non-alcoholic Fatty Liver Disease (enzymology), Non-alcoholic Fatty Liver Disease (etiology), Non-alcoholic Fatty Liver Disease (prevention & control), Permeability, Sphingomyelin Phosphodiesterase (antagonists & inhibitors), Sphingomyelin Phosphodiesterase (deficiency), Sphingomyelin Phosphodiesterase (metabolism), Sphingomyelins (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Sphingomyelin Phosphodiesterase.
- chemical , deficiency : Methionine, Sphingomyelin Phosphodiesterase.
- chemical , metabolism : Ceramides, Cholesterol, Sphingomyelin Phosphodiesterase, Sphingomyelins.
- chemical , pharmacology : Amitriptyline.
- adverse effects : Diet, High-Fat.
- complications : Choline Deficiency.
- enzymology : Non-alcoholic Fatty Liver Disease.
- etiology : Non-alcoholic Fatty Liver Disease.
- metabolism : Liver, Lysosomes.
- pathology : Liver.
- physiology : Autophagy.
- prevention & control : Non-alcoholic Fatty Liver Disease.
- Animals, Disease Models, Animal, Endoplasmic Reticulum Stress, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, Permeability.
Abstract
Acid sphingomyelinase (ASMase) is activated in non-alcoholic steatohepatitis (NASH). However, the contribution of ASMase to NASH is poorly understood and limited to hepatic steatosis and glucose metabolism. Here we examined the role of ASMase in high fat diet (HFD)-induced NASH.
DOI: 10.1016/j.jhep.2014.06.009
PubMed: 24946279
Links to Exploration step
pubmed:24946279Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis.</title><author><name sortKey="Fucho, Raquel" sort="Fucho, Raquel" uniqKey="Fucho R" first="Raquel" last="Fucho">Raquel Fucho</name><affiliation><nlm:affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Martinez, Laura" sort="Martinez, Laura" uniqKey="Martinez L" first="Laura" last="Martínez">Laura Martínez</name><affiliation><nlm:affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Baulies, Anna" sort="Baulies, Anna" uniqKey="Baulies A" first="Anna" last="Baulies">Anna Baulies</name><affiliation><nlm:affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Torres, Sandra" sort="Torres, Sandra" uniqKey="Torres S" first="Sandra" last="Torres">Sandra Torres</name><affiliation><nlm:affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Tarrats, Nuria" sort="Tarrats, Nuria" uniqKey="Tarrats N" first="Nuria" last="Tarrats">Nuria Tarrats</name><affiliation><nlm:affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez, Anna" sort="Fernandez, Anna" uniqKey="Fernandez A" first="Anna" last="Fernandez">Anna Fernandez</name><affiliation><nlm:affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ribas, Vicente" sort="Ribas, Vicente" uniqKey="Ribas V" first="Vicente" last="Ribas">Vicente Ribas</name><affiliation><nlm:affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Astudillo, Alma M" sort="Astudillo, Alma M" uniqKey="Astudillo A" first="Alma M" last="Astudillo">Alma M. Astudillo</name><affiliation><nlm:affiliation>Institute of Molecular Biology and Genetics CSIC, Medical School, University of Valladolid and CIBERDEM, Valladolid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Balsinde, Jesus" sort="Balsinde, Jesus" uniqKey="Balsinde J" first="Jesús" last="Balsinde">Jesús Balsinde</name><affiliation><nlm:affiliation>Institute of Molecular Biology and Genetics CSIC, Medical School, University of Valladolid and CIBERDEM, Valladolid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Garcia Roves, Pablo" sort="Garcia Roves, Pablo" uniqKey="Garcia Roves P" first="Pablo" last="Garcia-Rovés">Pablo Garcia-Rovés</name><affiliation><nlm:affiliation>Diabetes and Obesity Laboratory, IDIBAPS-Hospital Clinic de Barcelona, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Elena, Montserrat" sort="Elena, Montserrat" uniqKey="Elena M" first="Montserrat" last="Elena">Montserrat Elena</name><affiliation><nlm:affiliation>Biochemical Service, Hospital Clinic de Barcelona, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Bergheim, Ina" sort="Bergheim, Ina" uniqKey="Bergheim I" first="Ina" last="Bergheim">Ina Bergheim</name><affiliation><nlm:affiliation>Department of Nutritional Sciences, Friedrich-Schiller-University, Jena, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lotersztajn, Sophie" sort="Lotersztajn, Sophie" uniqKey="Lotersztajn S" first="Sophie" last="Lotersztajn">Sophie Lotersztajn</name><affiliation><nlm:affiliation>Université Paris-Est, UMR-S955, UPEC, Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Trautwein, Christian" sort="Trautwein, Christian" uniqKey="Trautwein C" first="Christian" last="Trautwein">Christian Trautwein</name><affiliation><nlm:affiliation>Department of Internal Medicine III, University Hospital, RWTH Aachen, Aachen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Appelqvist, Hanna" sort="Appelqvist, Hanna" uniqKey="Appelqvist H" first="Hanna" last="Appelqvist">Hanna Appelqvist</name><affiliation><nlm:affiliation>Experimental Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Paton, Adrienne W" sort="Paton, Adrienne W" uniqKey="Paton A" first="Adrienne W" last="Paton">Adrienne W. Paton</name><affiliation><nlm:affiliation>Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Paton, James C" sort="Paton, James C" uniqKey="Paton J" first="James C" last="Paton">James C. Paton</name><affiliation><nlm:affiliation>Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Czaja, Mark J" sort="Czaja, Mark J" uniqKey="Czaja M" first="Mark J" last="Czaja">Mark J. Czaja</name><affiliation><nlm:affiliation>Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, United States.</nlm:affiliation></affiliation></author><author><name sortKey="Kaplowitz, Neil" sort="Kaplowitz, Neil" uniqKey="Kaplowitz N" first="Neil" last="Kaplowitz">Neil Kaplowitz</name><affiliation><nlm:affiliation>Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Checa, Jose C" sort="Fernandez Checa, Jose C" uniqKey="Fernandez Checa J" first="Jose C" last="Fernandez-Checa">Jose C. Fernandez-Checa</name><affiliation><nlm:affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain; Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. Electronic address: checa229@yahoo.com.</nlm:affiliation></affiliation></author><author><name sortKey="Garcia Ruiz, Carmen" sort="Garcia Ruiz, Carmen" uniqKey="Garcia Ruiz C" first="Carmen" last="García-Ruiz">Carmen García-Ruiz</name><affiliation><nlm:affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain; Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. Electronic address: cgrbam@iibb.csic.es.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24946279</idno><idno type="pmid">24946279</idno><idno type="doi">10.1016/j.jhep.2014.06.009</idno><idno type="wicri:Area/PubMed/Corpus">003309</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003309</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis.</title><author><name sortKey="Fucho, Raquel" sort="Fucho, Raquel" uniqKey="Fucho R" first="Raquel" last="Fucho">Raquel Fucho</name><affiliation><nlm:affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Martinez, Laura" sort="Martinez, Laura" uniqKey="Martinez L" first="Laura" last="Martínez">Laura Martínez</name><affiliation><nlm:affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Baulies, Anna" sort="Baulies, Anna" uniqKey="Baulies A" first="Anna" last="Baulies">Anna Baulies</name><affiliation><nlm:affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Torres, Sandra" sort="Torres, Sandra" uniqKey="Torres S" first="Sandra" last="Torres">Sandra Torres</name><affiliation><nlm:affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Tarrats, Nuria" sort="Tarrats, Nuria" uniqKey="Tarrats N" first="Nuria" last="Tarrats">Nuria Tarrats</name><affiliation><nlm:affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez, Anna" sort="Fernandez, Anna" uniqKey="Fernandez A" first="Anna" last="Fernandez">Anna Fernandez</name><affiliation><nlm:affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ribas, Vicente" sort="Ribas, Vicente" uniqKey="Ribas V" first="Vicente" last="Ribas">Vicente Ribas</name><affiliation><nlm:affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Astudillo, Alma M" sort="Astudillo, Alma M" uniqKey="Astudillo A" first="Alma M" last="Astudillo">Alma M. Astudillo</name><affiliation><nlm:affiliation>Institute of Molecular Biology and Genetics CSIC, Medical School, University of Valladolid and CIBERDEM, Valladolid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Balsinde, Jesus" sort="Balsinde, Jesus" uniqKey="Balsinde J" first="Jesús" last="Balsinde">Jesús Balsinde</name><affiliation><nlm:affiliation>Institute of Molecular Biology and Genetics CSIC, Medical School, University of Valladolid and CIBERDEM, Valladolid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Garcia Roves, Pablo" sort="Garcia Roves, Pablo" uniqKey="Garcia Roves P" first="Pablo" last="Garcia-Rovés">Pablo Garcia-Rovés</name><affiliation><nlm:affiliation>Diabetes and Obesity Laboratory, IDIBAPS-Hospital Clinic de Barcelona, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Elena, Montserrat" sort="Elena, Montserrat" uniqKey="Elena M" first="Montserrat" last="Elena">Montserrat Elena</name><affiliation><nlm:affiliation>Biochemical Service, Hospital Clinic de Barcelona, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Bergheim, Ina" sort="Bergheim, Ina" uniqKey="Bergheim I" first="Ina" last="Bergheim">Ina Bergheim</name><affiliation><nlm:affiliation>Department of Nutritional Sciences, Friedrich-Schiller-University, Jena, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lotersztajn, Sophie" sort="Lotersztajn, Sophie" uniqKey="Lotersztajn S" first="Sophie" last="Lotersztajn">Sophie Lotersztajn</name><affiliation><nlm:affiliation>Université Paris-Est, UMR-S955, UPEC, Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Trautwein, Christian" sort="Trautwein, Christian" uniqKey="Trautwein C" first="Christian" last="Trautwein">Christian Trautwein</name><affiliation><nlm:affiliation>Department of Internal Medicine III, University Hospital, RWTH Aachen, Aachen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Appelqvist, Hanna" sort="Appelqvist, Hanna" uniqKey="Appelqvist H" first="Hanna" last="Appelqvist">Hanna Appelqvist</name><affiliation><nlm:affiliation>Experimental Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Paton, Adrienne W" sort="Paton, Adrienne W" uniqKey="Paton A" first="Adrienne W" last="Paton">Adrienne W. Paton</name><affiliation><nlm:affiliation>Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Paton, James C" sort="Paton, James C" uniqKey="Paton J" first="James C" last="Paton">James C. Paton</name><affiliation><nlm:affiliation>Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Czaja, Mark J" sort="Czaja, Mark J" uniqKey="Czaja M" first="Mark J" last="Czaja">Mark J. Czaja</name><affiliation><nlm:affiliation>Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, United States.</nlm:affiliation></affiliation></author><author><name sortKey="Kaplowitz, Neil" sort="Kaplowitz, Neil" uniqKey="Kaplowitz N" first="Neil" last="Kaplowitz">Neil Kaplowitz</name><affiliation><nlm:affiliation>Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Checa, Jose C" sort="Fernandez Checa, Jose C" uniqKey="Fernandez Checa J" first="Jose C" last="Fernandez-Checa">Jose C. Fernandez-Checa</name><affiliation><nlm:affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain; Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. Electronic address: checa229@yahoo.com.</nlm:affiliation></affiliation></author><author><name sortKey="Garcia Ruiz, Carmen" sort="Garcia Ruiz, Carmen" uniqKey="Garcia Ruiz C" first="Carmen" last="García-Ruiz">Carmen García-Ruiz</name><affiliation><nlm:affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain; Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. Electronic address: cgrbam@iibb.csic.es.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of hepatology</title><idno type="eISSN">1600-0641</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amitriptyline (pharmacology)</term><term>Animals</term><term>Autophagy (physiology)</term><term>Ceramides (metabolism)</term><term>Cholesterol (metabolism)</term><term>Choline Deficiency (complications)</term><term>Diet, High-Fat (adverse effects)</term><term>Disease Models, Animal</term><term>Endoplasmic Reticulum Stress</term><term>Humans</term><term>Liver (metabolism)</term><term>Liver (pathology)</term><term>Lysosomes (metabolism)</term><term>Methionine (deficiency)</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Non-alcoholic Fatty Liver Disease (enzymology)</term><term>Non-alcoholic Fatty Liver Disease (etiology)</term><term>Non-alcoholic Fatty Liver Disease (prevention & control)</term><term>Permeability</term><term>Sphingomyelin Phosphodiesterase (antagonists & inhibitors)</term><term>Sphingomyelin Phosphodiesterase (deficiency)</term><term>Sphingomyelin Phosphodiesterase (metabolism)</term><term>Sphingomyelins (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Sphingomyelin Phosphodiesterase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Methionine</term><term>Sphingomyelin Phosphodiesterase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Ceramides</term><term>Cholesterol</term><term>Sphingomyelin Phosphodiesterase</term><term>Sphingomyelins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Amitriptyline</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Diet, High-Fat</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Choline Deficiency</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Non-alcoholic Fatty Liver Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Non-alcoholic Fatty Liver Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Liver</term><term>Lysosomes</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Liver</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Autophagy</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Non-alcoholic Fatty Liver Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Endoplasmic Reticulum Stress</term><term>Humans</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Permeability</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Acid sphingomyelinase (ASMase) is activated in non-alcoholic steatohepatitis (NASH). However, the contribution of ASMase to NASH is poorly understood and limited to hepatic steatosis and glucose metabolism. Here we examined the role of ASMase in high fat diet (HFD)-induced NASH.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24946279</PMID><DateCreated><Year>2014</Year><Month>10</Month><Day>20</Day></DateCreated><DateCompleted><Year>2015</Year><Month>06</Month><Day>26</Day></DateCompleted><DateRevised><Year>2017</Year><Month>04</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-0641</ISSN><JournalIssue CitedMedium="Internet"><Volume>61</Volume><Issue>5</Issue><PubDate><Year>2014</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Journal of hepatology</Title><ISOAbbreviation>J. Hepatol.</ISOAbbreviation></Journal><ArticleTitle>ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis.</ArticleTitle><Pagination><MedlinePgn>1126-34</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jhep.2014.06.009</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0168-8278(14)00404-8</ELocationID><Abstract><AbstractText Label="BACKGROUND & AIMS" NlmCategory="OBJECTIVE">Acid sphingomyelinase (ASMase) is activated in non-alcoholic steatohepatitis (NASH). However, the contribution of ASMase to NASH is poorly understood and limited to hepatic steatosis and glucose metabolism. Here we examined the role of ASMase in high fat diet (HFD)-induced NASH.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Autophagy, endoplasmic reticulum (ER) stress and lysosomal membrane permeabilization (LMP) were determined in ASMase(-/-) mice fed a HFD. The impact of pharmacological ASMase inhibition on NASH was analyzed in wild type mice fed a HFD.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">ASMase deficiency determined resistance to hepatic steatosis mediated by a HFD or methionine-choline deficient diet. ASMase(-/-) mice were resistant to HFD-induced hepatic ER stress, but sensitive to tunicamycin-mediated ER stress, indicating selectivity in the resistance of ASMase(-/-) mice to ER stress and steatosis. Autophagic flux, determined in the presence of rapamycin and/or chloroquine, was lower in primary mouse hepatocytes (PMH) from ASMase(-/-) mice and accompanied by increased p62 levels, suggesting autophagic impairment. Moreover, autophagy suppression by chloroquine and brefeldin A caused ER stress in PMH from ASMase(+/+) mice but not in ASMase(-/-) mice. ASMase(-/-) PMH exhibited increased lysosomal cholesterol loading, decreased LMP and apoptosis resistance induced by O-methyl-serine dodecylamide hydrochloride or palmitic acid, effects that were reversed by decreasing cholesterol levels by oxysterol 25-hydroxycholesterol. In vivo pharmacological ASMase inhibition by amitriptyline, a widely used tricyclic antidepressant, protected wild type mice against HFD-induced hepatic steatosis, fibrosis, and liver damage, effects indicative of early-stage NASH.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These findings underscore a critical role for ASMase in diet-induced NASH and suggest the potential of amitriptyline as a treatment for patients with NASH.</AbstractText><CopyrightInformation>Copyright © 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fucho</LastName><ForeName>Raquel</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martínez</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baulies</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Torres</LastName><ForeName>Sandra</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tarrats</LastName><ForeName>Nuria</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernandez</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ribas</LastName><ForeName>Vicente</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Astudillo</LastName><ForeName>Alma M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Institute of Molecular Biology and Genetics CSIC, Medical School, University of Valladolid and CIBERDEM, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balsinde</LastName><ForeName>Jesús</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Molecular Biology and Genetics CSIC, Medical School, University of Valladolid and CIBERDEM, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garcia-Rovés</LastName><ForeName>Pablo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Diabetes and Obesity Laboratory, IDIBAPS-Hospital Clinic de Barcelona, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elena</LastName><ForeName>Montserrat</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Biochemical Service, Hospital Clinic de Barcelona, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bergheim</LastName><ForeName>Ina</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Nutritional Sciences, Friedrich-Schiller-University, Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lotersztajn</LastName><ForeName>Sophie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Université Paris-Est, UMR-S955, UPEC, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trautwein</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine III, University Hospital, RWTH Aachen, Aachen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Appelqvist</LastName><ForeName>Hanna</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Experimental Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paton</LastName><ForeName>Adrienne W</ForeName><Initials>AW</Initials><AffiliationInfo><Affiliation>Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paton</LastName><ForeName>James C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Czaja</LastName><ForeName>Mark J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaplowitz</LastName><ForeName>Neil</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernandez-Checa</LastName><ForeName>Jose C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain; Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. Electronic address: checa229@yahoo.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García-Ruiz</LastName><ForeName>Carmen</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain; Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. Electronic address: cgrbam@iibb.csic.es.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 DK044234</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 DK041296</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50-AA-11999</GrantID><Acronym>AA</Acronym><Agency>NIAAA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 AA011999</GrantID><Acronym>AA</Acronym><Agency>NIAAA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 DK061498</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 AA014135</GrantID><Acronym>AA</Acronym><Agency>NIAAA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>06</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Hepatol</MedlineTA><NlmUniqueID>8503886</NlmUniqueID><ISSNLinking>0168-8278</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002518">Ceramides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013109">Sphingomyelins</NameOfSubstance></Chemical><Chemical><RegistryNumber>1806D8D52K</RegistryNumber><NameOfSubstance UI="D000639">Amitriptyline</NameOfSubstance></Chemical><Chemical><RegistryNumber>97C5T2UQ7J</RegistryNumber><NameOfSubstance UI="D002784">Cholesterol</NameOfSubstance></Chemical><Chemical><RegistryNumber>AE28F7PNPL</RegistryNumber><NameOfSubstance UI="D008715">Methionine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.4.12</RegistryNumber><NameOfSubstance UI="C577975">ASMase, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.4.12</RegistryNumber><NameOfSubstance UI="D013108">Sphingomyelin Phosphodiesterase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Hepatology. 2008 May;47(5):1495-503</RefSource><PMID Version="1">18220271</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Apoptosis. 2007 May;12(5):923-39</RefSource><PMID Version="1">17294080</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hepatology. 2009 Apr;49(4):1297-307</RefSource><PMID Version="1">19116891</PMID></CommentsCorrections><CommentsCorrections 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MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002796" MajorTopicYN="N">Choline Deficiency</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059305" MajorTopicYN="N">Diet, High-Fat</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059865" MajorTopicYN="N">Endoplasmic Reticulum Stress</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008247" MajorTopicYN="N">Lysosomes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008715" MajorTopicYN="N">Methionine</DescriptorName><QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D065626" MajorTopicYN="N">Non-alcoholic Fatty Liver Disease</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010539" MajorTopicYN="N">Permeability</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013108" MajorTopicYN="N">Sphingomyelin Phosphodiesterase</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName><QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013109" MajorTopicYN="N">Sphingomyelins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS606750</OtherID><OtherID Source="NLM">PMC4203709</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Autophagy</Keyword><Keyword MajorTopicYN="N">Ceramide</Keyword><Keyword MajorTopicYN="N">Endoplasmic reticulum stress</Keyword><Keyword MajorTopicYN="N">Fatty liver</Keyword><Keyword MajorTopicYN="N">Lysosomal membrane permeabilization</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>02</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>05</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>06</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>6</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>6</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>6</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24946279</ArticleId><ArticleId IdType="pii">S0168-8278(14)00404-8</ArticleId><ArticleId IdType="doi">10.1016/j.jhep.2014.06.009</ArticleId><ArticleId IdType="pmc">PMC4203709</ArticleId><ArticleId IdType="mid">NIHMS606750</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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