Molecular evolution and antigenic variation of European brown hare syndrome virus (EBHSV).
Identifieur interne : 003301 ( PubMed/Corpus ); précédent : 003300; suivant : 003302Molecular evolution and antigenic variation of European brown hare syndrome virus (EBHSV).
Auteurs : Ana M. Lopes ; Lorenzo Capucci ; Dolores Gavier-Widén ; Ghislaine Le Gall-Reculé ; Emiliana Brocchi ; Ilaria Barbieri ; Agnès Quéméner ; Jacques Le Pendu ; Jemma L. Geoghegan ; Edward C. Holmes ; Pedro J. Esteves ; Joana AbrantesSource :
- Virology [ 1096-0341 ] ; 2014.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal, Antibodies, Viral, Antigens, Viral (genetics), Antigens, Viral (metabolism), Bunyaviridae Infections (epidemiology), Bunyaviridae Infections (veterinary), Bunyaviridae Infections (virology), Epitopes (genetics), Evolution, Molecular, Gene Expression Regulation, Viral (physiology), Genetic Variation, Hares (virology), Lagovirus (genetics), Liver (virology), Models, Molecular, Phylogeny, Protein Conformation, Sweden (epidemiology), Time Factors.
- MESH :
- chemical , genetics : Antigens, Viral, Epitopes.
- chemical , metabolism : Antigens, Viral.
- chemical : Antibodies, Monoclonal, Antibodies, Viral.
- geographic , epidemiology : Sweden.
- epidemiology : Bunyaviridae Infections.
- genetics : Lagovirus.
- physiology : Gene Expression Regulation, Viral.
- veterinary : Bunyaviridae Infections.
- virology : Bunyaviridae Infections, Hares, Liver.
- Animals, Evolution, Molecular, Genetic Variation, Models, Molecular, Phylogeny, Protein Conformation, Time Factors.
Abstract
European brown hare syndrome virus (EBHSV) is the aetiological agent of European brown hare syndrome (EBHS), a disease affecting Lepus europaeus and Lepus timidus first diagnosed in Sweden in 1980. To characterize EBHSV evolution we studied hare samples collected in Sweden between 1982 and 2008. Our molecular clock dating is compatible with EBHSV emergence in the 1970s. Phylogenetic analysis revealed two lineages: Group A persisted until 1989 when it apparently suffered extinction; Group B emerged in the mid-1980s and contains the most recent strains. Antigenic differences exist between groups, with loss of reactivity of some MAbs over time, which are associated with amino acid substitutions in recognized epitopes. A role for immune selection is also supported by the presence of positively selected codons in exposed regions of the capsid. Hence, EBHSV evolution is characterized by replacement of Group A by Group B viruses, suggesting that the latter possess a selective advantage.
DOI: 10.1016/j.virol.2014.08.002
PubMed: 25155199
Links to Exploration step
pubmed:25155199Le document en format XML
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Geoghegan</name><affiliation><nlm:affiliation>Sydney Emerging Infectious and Biosecurity Institute, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: jemma.geoghegan@sydney.edu.au.</nlm:affiliation></affiliation></author><author><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C" last="Holmes">Edward C. Holmes</name><affiliation><nlm:affiliation>Sydney Emerging Infectious and Biosecurity Institute, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: edward.holmes@sydney.edu.au.</nlm:affiliation></affiliation></author><author><name sortKey="Esteves, Pedro J" sort="Esteves, Pedro J" uniqKey="Esteves P" first="Pedro J" last="Esteves">Pedro J. Esteves</name><affiliation><nlm:affiliation>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão, Portugal; Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal; CITS, Centro de Investigação em Tecnologias da Saúde, IPSN, CESPU, Gandra, Portugal. Electronic address: pjesteves@cibio.up.pt.</nlm:affiliation></affiliation></author><author><name sortKey="Abrantes, Joana" sort="Abrantes, Joana" uniqKey="Abrantes J" first="Joana" last="Abrantes">Joana Abrantes</name><affiliation><nlm:affiliation>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão, Portugal. Electronic address: jabrantes@cibio.up.pt.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25155199</idno><idno type="pmid">25155199</idno><idno type="doi">10.1016/j.virol.2014.08.002</idno><idno type="wicri:Area/PubMed/Corpus">003301</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003301</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Molecular evolution and antigenic variation of European brown hare syndrome virus (EBHSV).</title><author><name sortKey="Lopes, Ana M" sort="Lopes, Ana M" uniqKey="Lopes A" first="Ana M" last="Lopes">Ana M. Lopes</name><affiliation><nlm:affiliation>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão, Portugal; Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal; INSERM, UMR892, CNRS, UMR6299, Université de Nantes, Nantes, France. Electronic address: analopes@cibio.up.pt.</nlm:affiliation></affiliation></author><author><name sortKey="Capucci, Lorenzo" sort="Capucci, Lorenzo" uniqKey="Capucci L" first="Lorenzo" last="Capucci">Lorenzo Capucci</name><affiliation><nlm:affiliation>Istituto Zooprofilattico Sperimentale della Lombardia e dell׳Emilia Romagna, Via Bianchi 9, 25124 Brescia, Italy. Electronic address: lorenzo.capucci@izsler.it.</nlm:affiliation></affiliation></author><author><name sortKey="Gavier Widen, Dolores" sort="Gavier Widen, Dolores" uniqKey="Gavier Widen D" first="Dolores" last="Gavier-Widén">Dolores Gavier-Widén</name><affiliation><nlm:affiliation>Department of Pathology and Wildlife Disease, National Veterinary Institute (SVA), Uppsala, Sweden; Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden. Electronic address: dolores.gavier-widen@sva.se.</nlm:affiliation></affiliation></author><author><name sortKey="Le Gall Recule, Ghislaine" sort="Le Gall Recule, Ghislaine" uniqKey="Le Gall Recule G" first="Ghislaine" last="Le Gall-Reculé">Ghislaine Le Gall-Reculé</name><affiliation><nlm:affiliation>Anses, Ploufragan-Plouzané Laboratory, Avian and Rabbit Virology, Immunology, and Parasitology Unit, Ploufragan, France; European University of Brittany, Rennes, France. Electronic address: ghislaine.legall-recule@anses.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Brocchi, Emiliana" sort="Brocchi, Emiliana" uniqKey="Brocchi E" first="Emiliana" last="Brocchi">Emiliana Brocchi</name><affiliation><nlm:affiliation>Istituto Zooprofilattico Sperimentale della Lombardia e dell׳Emilia Romagna, Via Bianchi 9, 25124 Brescia, Italy. Electronic address: emiliana.brocchi@izsler.it.</nlm:affiliation></affiliation></author><author><name sortKey="Barbieri, Ilaria" sort="Barbieri, Ilaria" uniqKey="Barbieri I" first="Ilaria" last="Barbieri">Ilaria Barbieri</name><affiliation><nlm:affiliation>Istituto Zooprofilattico Sperimentale della Lombardia e dell׳Emilia Romagna, Via Bianchi 9, 25124 Brescia, Italy. Electronic address: ilaria.barbieri@izsler.it.</nlm:affiliation></affiliation></author><author><name sortKey="Quemener, Agnes" sort="Quemener, Agnes" uniqKey="Quemener A" first="Agnès" last="Quéméner">Agnès Quéméner</name><affiliation><nlm:affiliation>INSERM, UMR892, CNRS, UMR6299, Université de Nantes, Nantes, France. Electronic address: agnes.quemener@nantes.inserm.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Le Pendu, Jacques" sort="Le Pendu, Jacques" uniqKey="Le Pendu J" first="Jacques" last="Le Pendu">Jacques Le Pendu</name><affiliation><nlm:affiliation>INSERM, UMR892, CNRS, UMR6299, Université de Nantes, Nantes, France. Electronic address: jacques.le-pendu@univ-nantes.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Geoghegan, Jemma L" sort="Geoghegan, Jemma L" uniqKey="Geoghegan J" first="Jemma L" last="Geoghegan">Jemma L. Geoghegan</name><affiliation><nlm:affiliation>Sydney Emerging Infectious and Biosecurity Institute, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: jemma.geoghegan@sydney.edu.au.</nlm:affiliation></affiliation></author><author><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C" last="Holmes">Edward C. Holmes</name><affiliation><nlm:affiliation>Sydney Emerging Infectious and Biosecurity Institute, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: edward.holmes@sydney.edu.au.</nlm:affiliation></affiliation></author><author><name sortKey="Esteves, Pedro J" sort="Esteves, Pedro J" uniqKey="Esteves P" first="Pedro J" last="Esteves">Pedro J. Esteves</name><affiliation><nlm:affiliation>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão, Portugal; Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal; CITS, Centro de Investigação em Tecnologias da Saúde, IPSN, CESPU, Gandra, Portugal. Electronic address: pjesteves@cibio.up.pt.</nlm:affiliation></affiliation></author><author><name sortKey="Abrantes, Joana" sort="Abrantes, Joana" uniqKey="Abrantes J" first="Joana" last="Abrantes">Joana Abrantes</name><affiliation><nlm:affiliation>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão, Portugal. Electronic address: jabrantes@cibio.up.pt.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Virology</title><idno type="eISSN">1096-0341</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal</term><term>Antibodies, Viral</term><term>Antigens, Viral (genetics)</term><term>Antigens, Viral (metabolism)</term><term>Bunyaviridae Infections (epidemiology)</term><term>Bunyaviridae Infections (veterinary)</term><term>Bunyaviridae Infections (virology)</term><term>Epitopes (genetics)</term><term>Evolution, Molecular</term><term>Gene Expression Regulation, Viral (physiology)</term><term>Genetic Variation</term><term>Hares (virology)</term><term>Lagovirus (genetics)</term><term>Liver (virology)</term><term>Models, Molecular</term><term>Phylogeny</term><term>Protein Conformation</term><term>Sweden (epidemiology)</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Viral</term><term>Epitopes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, Viral</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Sweden</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Bunyaviridae Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lagovirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gene Expression Regulation, Viral</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Bunyaviridae Infections</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Bunyaviridae Infections</term><term>Hares</term><term>Liver</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Evolution, Molecular</term><term>Genetic Variation</term><term>Models, Molecular</term><term>Phylogeny</term><term>Protein Conformation</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">European brown hare syndrome virus (EBHSV) is the aetiological agent of European brown hare syndrome (EBHS), a disease affecting Lepus europaeus and Lepus timidus first diagnosed in Sweden in 1980. To characterize EBHSV evolution we studied hare samples collected in Sweden between 1982 and 2008. Our molecular clock dating is compatible with EBHSV emergence in the 1970s. Phylogenetic analysis revealed two lineages: Group A persisted until 1989 when it apparently suffered extinction; Group B emerged in the mid-1980s and contains the most recent strains. Antigenic differences exist between groups, with loss of reactivity of some MAbs over time, which are associated with amino acid substitutions in recognized epitopes. A role for immune selection is also supported by the presence of positively selected codons in exposed regions of the capsid. Hence, EBHSV evolution is characterized by replacement of Group A by Group B viruses, suggesting that the latter possess a selective advantage.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25155199</PMID><DateCreated><Year>2014</Year><Month>12</Month><Day>02</Day></DateCreated><DateCompleted><Year>2015</Year><Month>02</Month><Day>17</Day></DateCompleted><DateRevised><Year>2014</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-0341</ISSN><JournalIssue CitedMedium="Internet"><Volume>468-470</Volume><PubDate><Year>2014</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Virology</Title><ISOAbbreviation>Virology</ISOAbbreviation></Journal><ArticleTitle>Molecular evolution and antigenic variation of European brown hare syndrome virus (EBHSV).</ArticleTitle><Pagination><MedlinePgn>104-12</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.virol.2014.08.002</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0042-6822(14)00373-0</ELocationID><Abstract><AbstractText>European brown hare syndrome virus (EBHSV) is the aetiological agent of European brown hare syndrome (EBHS), a disease affecting Lepus europaeus and Lepus timidus first diagnosed in Sweden in 1980. To characterize EBHSV evolution we studied hare samples collected in Sweden between 1982 and 2008. Our molecular clock dating is compatible with EBHSV emergence in the 1970s. Phylogenetic analysis revealed two lineages: Group A persisted until 1989 when it apparently suffered extinction; Group B emerged in the mid-1980s and contains the most recent strains. Antigenic differences exist between groups, with loss of reactivity of some MAbs over time, which are associated with amino acid substitutions in recognized epitopes. A role for immune selection is also supported by the presence of positively selected codons in exposed regions of the capsid. Hence, EBHSV evolution is characterized by replacement of Group A by Group B viruses, suggesting that the latter possess a selective advantage.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lopes</LastName><ForeName>Ana M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão, Portugal; Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal; INSERM, UMR892, CNRS, UMR6299, Université de Nantes, Nantes, France. Electronic address: analopes@cibio.up.pt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Capucci</LastName><ForeName>Lorenzo</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Istituto Zooprofilattico Sperimentale della Lombardia e dell׳Emilia Romagna, Via Bianchi 9, 25124 Brescia, Italy. Electronic address: lorenzo.capucci@izsler.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gavier-Widén</LastName><ForeName>Dolores</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Pathology and Wildlife Disease, National Veterinary Institute (SVA), Uppsala, Sweden; Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden. Electronic address: dolores.gavier-widen@sva.se.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Gall-Reculé</LastName><ForeName>Ghislaine</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Anses, Ploufragan-Plouzané Laboratory, Avian and Rabbit Virology, Immunology, and Parasitology Unit, Ploufragan, France; European University of Brittany, Rennes, France. Electronic address: ghislaine.legall-recule@anses.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brocchi</LastName><ForeName>Emiliana</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Istituto Zooprofilattico Sperimentale della Lombardia e dell׳Emilia Romagna, Via Bianchi 9, 25124 Brescia, Italy. Electronic address: emiliana.brocchi@izsler.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barbieri</LastName><ForeName>Ilaria</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Istituto Zooprofilattico Sperimentale della Lombardia e dell׳Emilia Romagna, Via Bianchi 9, 25124 Brescia, Italy. Electronic address: ilaria.barbieri@izsler.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quéméner</LastName><ForeName>Agnès</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>INSERM, UMR892, CNRS, UMR6299, Université de Nantes, Nantes, France. Electronic address: agnes.quemener@nantes.inserm.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Pendu</LastName><ForeName>Jacques</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>INSERM, UMR892, CNRS, UMR6299, Université de Nantes, Nantes, France. Electronic address: jacques.le-pendu@univ-nantes.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Geoghegan</LastName><ForeName>Jemma L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Sydney Emerging Infectious and Biosecurity Institute, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: jemma.geoghegan@sydney.edu.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holmes</LastName><ForeName>Edward C</ForeName><Initials>EC</Initials><AffiliationInfo><Affiliation>Sydney Emerging Infectious and Biosecurity Institute, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: edward.holmes@sydney.edu.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Esteves</LastName><ForeName>Pedro J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão, Portugal; Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal; CITS, Centro de Investigação em Tecnologias da Saúde, IPSN, CESPU, Gandra, Portugal. Electronic address: pjesteves@cibio.up.pt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abrantes</LastName><ForeName>Joana</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão, Portugal. Electronic address: jabrantes@cibio.up.pt.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>08</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Virology</MedlineTA><NlmUniqueID>0110674</NlmUniqueID><ISSNLinking>0042-6822</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000956">Antigens, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000939">Epitopes</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000911" MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000956" MajorTopicYN="N">Antigens, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002044" MajorTopicYN="N">Bunyaviridae Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000939" MajorTopicYN="N">Epitopes</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019143" MajorTopicYN="Y">Evolution, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015967" MajorTopicYN="N">Gene Expression Regulation, Viral</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014644" MajorTopicYN="Y">Genetic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D034621" MajorTopicYN="N">Hares</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029321" MajorTopicYN="N">Lagovirus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008958" MajorTopicYN="N">Models, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011487" MajorTopicYN="N">Protein Conformation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013548" MajorTopicYN="N" Type="Geographic">Sweden</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antigenic variation</Keyword><Keyword MajorTopicYN="N">European brown hare syndrome virus (EBHSV)</Keyword><Keyword MajorTopicYN="N">Evolution</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>06</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>07</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>08</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>8</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>8</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>2</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25155199</ArticleId><ArticleId IdType="pii">S0042-6822(14)00373-0</ArticleId><ArticleId IdType="doi">10.1016/j.virol.2014.08.002</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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