A ternary model of decompression sickness in rats.
Identifieur interne : 003220 ( PubMed/Corpus ); précédent : 003219; suivant : 003221A ternary model of decompression sickness in rats.
Auteurs : Peter Buzzacott ; Kate Lambrechts ; Aleksandra Mazur ; Qiong Wang ; Virginie Papadopoulou ; Michael Theron ; Costantino Balestra ; François GuerreroSource :
- Computers in biology and medicine [ 1879-0534 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- physiopathology : Decompression Sickness.
- Animals, Disease Models, Animal, Female, Logistic Models, Male, Odds Ratio, Rats, Rats, Sprague-Dawley, Rats, Wistar, Reproducibility of Results.
Abstract
Decompression sickness (DCS) in rats is commonly modelled as a binary outcome. The present study aimed to develop a ternary model of predicting probability of DCS in rats, (as no-DCS, survivable-DCS or death), based upon the compression/decompression profile and physiological characteristics of each rat.
DOI: 10.1016/j.compbiomed.2014.10.012
PubMed: 25450221
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Electronic address: peter.buzzacott@uwa.edu.au.</nlm:affiliation></affiliation></author><author><name sortKey="Lambrechts, Kate" sort="Lambrechts, Kate" uniqKey="Lambrechts K" first="Kate" last="Lambrechts">Kate Lambrechts</name><affiliation><nlm:affiliation>Université de Bretagne Occidentale, Laboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, 6 avenue Le Gorgeu, CS 93837, 29200 Brest Cedex 3, France. Electronic address: lambrechtskate@hotmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Mazur, Aleksandra" sort="Mazur, Aleksandra" uniqKey="Mazur A" first="Aleksandra" last="Mazur">Aleksandra Mazur</name><affiliation><nlm:affiliation>Université de Bretagne Occidentale, Laboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, 6 avenue Le Gorgeu, CS 93837, 29200 Brest Cedex 3, France. Electronic address: maz.aleksandra@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Qiong" sort="Wang, Qiong" uniqKey="Wang Q" first="Qiong" last="Wang">Qiong Wang</name><affiliation><nlm:affiliation>Université de Bretagne Occidentale, Laboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, 6 avenue Le Gorgeu, CS 93837, 29200 Brest Cedex 3, France. Electronic address: qiong.wang@etudiant.univ-brest.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Papadopoulou, Virginie" sort="Papadopoulou, Virginie" uniqKey="Papadopoulou V" first="Virginie" last="Papadopoulou">Virginie Papadopoulou</name><affiliation><nlm:affiliation>Department of Bioengineering, Imperial College London, London, United Kingdom. Electronic address: virginie.papadopoulou07@imperial.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Theron, Michael" sort="Theron, Michael" uniqKey="Theron M" first="Michael" last="Theron">Michael Theron</name><affiliation><nlm:affiliation>Université de Bretagne Occidentale, Laboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, 6 avenue Le Gorgeu, CS 93837, 29200 Brest Cedex 3, France. Electronic address: Michael.Theron@univ-brest.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Balestra, Costantino" sort="Balestra, Costantino" uniqKey="Balestra C" first="Costantino" last="Balestra">Costantino Balestra</name><affiliation><nlm:affiliation>Haute Ecole Paul Henri-Spaak, Environmental, Occupational & Ageing (Integrative) Physiology Laboratory, Brussels, Belgium; DAN Europe Research Division, Brussels, Belgium. Electronic address: daneuben@skynet.be.</nlm:affiliation></affiliation></author><author><name sortKey="Guerrero, Francois" sort="Guerrero, Francois" uniqKey="Guerrero F" first="François" last="Guerrero">François Guerrero</name><affiliation><nlm:affiliation>Université de Bretagne Occidentale, Laboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, 6 avenue Le Gorgeu, CS 93837, 29200 Brest Cedex 3, France. Electronic address: francois.guerrero@univ-brest.fr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25450221</idno><idno type="pmid">25450221</idno><idno type="doi">10.1016/j.compbiomed.2014.10.012</idno><idno type="wicri:Area/PubMed/Corpus">003220</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003220</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A ternary model of decompression sickness in rats.</title><author><name sortKey="Buzzacott, Peter" sort="Buzzacott, Peter" uniqKey="Buzzacott P" first="Peter" last="Buzzacott">Peter Buzzacott</name><affiliation><nlm:affiliation>Université de Bretagne Occidentale, Laboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, 6 avenue Le Gorgeu, CS 93837, 29200 Brest Cedex 3, France; School of Sports Science, Exercise and Health, the University of Western Australia, 35 Stirling Highway, Crawley WA 6009, Australia. Electronic address: peter.buzzacott@uwa.edu.au.</nlm:affiliation></affiliation></author><author><name sortKey="Lambrechts, Kate" sort="Lambrechts, Kate" uniqKey="Lambrechts K" first="Kate" last="Lambrechts">Kate Lambrechts</name><affiliation><nlm:affiliation>Université de Bretagne Occidentale, Laboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, 6 avenue Le Gorgeu, CS 93837, 29200 Brest Cedex 3, France. Electronic address: lambrechtskate@hotmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Mazur, Aleksandra" sort="Mazur, Aleksandra" uniqKey="Mazur A" first="Aleksandra" last="Mazur">Aleksandra Mazur</name><affiliation><nlm:affiliation>Université de Bretagne Occidentale, Laboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, 6 avenue Le Gorgeu, CS 93837, 29200 Brest Cedex 3, France. Electronic address: maz.aleksandra@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Qiong" sort="Wang, Qiong" uniqKey="Wang Q" first="Qiong" last="Wang">Qiong Wang</name><affiliation><nlm:affiliation>Université de Bretagne Occidentale, Laboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, 6 avenue Le Gorgeu, CS 93837, 29200 Brest Cedex 3, France. Electronic address: qiong.wang@etudiant.univ-brest.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Papadopoulou, Virginie" sort="Papadopoulou, Virginie" uniqKey="Papadopoulou V" first="Virginie" last="Papadopoulou">Virginie Papadopoulou</name><affiliation><nlm:affiliation>Department of Bioengineering, Imperial College London, London, United Kingdom. Electronic address: virginie.papadopoulou07@imperial.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Theron, Michael" sort="Theron, Michael" uniqKey="Theron M" first="Michael" last="Theron">Michael Theron</name><affiliation><nlm:affiliation>Université de Bretagne Occidentale, Laboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, 6 avenue Le Gorgeu, CS 93837, 29200 Brest Cedex 3, France. Electronic address: Michael.Theron@univ-brest.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Balestra, Costantino" sort="Balestra, Costantino" uniqKey="Balestra C" first="Costantino" last="Balestra">Costantino Balestra</name><affiliation><nlm:affiliation>Haute Ecole Paul Henri-Spaak, Environmental, Occupational & Ageing (Integrative) Physiology Laboratory, Brussels, Belgium; DAN Europe Research Division, Brussels, Belgium. Electronic address: daneuben@skynet.be.</nlm:affiliation></affiliation></author><author><name sortKey="Guerrero, Francois" sort="Guerrero, Francois" uniqKey="Guerrero F" first="François" last="Guerrero">François Guerrero</name><affiliation><nlm:affiliation>Université de Bretagne Occidentale, Laboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, 6 avenue Le Gorgeu, CS 93837, 29200 Brest Cedex 3, France. Electronic address: francois.guerrero@univ-brest.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Computers in biology and medicine</title><idno type="eISSN">1879-0534</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Decompression Sickness (physiopathology)</term><term>Disease Models, Animal</term><term>Female</term><term>Logistic Models</term><term>Male</term><term>Odds Ratio</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Rats, Wistar</term><term>Reproducibility of Results</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Decompression Sickness</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Logistic Models</term><term>Male</term><term>Odds Ratio</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Rats, Wistar</term><term>Reproducibility of Results</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Decompression sickness (DCS) in rats is commonly modelled as a binary outcome. The present study aimed to develop a ternary model of predicting probability of DCS in rats, (as no-DCS, survivable-DCS or death), based upon the compression/decompression profile and physiological characteristics of each rat.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25450221</PMID><DateCreated><Year>2014</Year><Month>12</Month><Day>03</Day></DateCreated><DateCompleted><Year>2015</Year><Month>07</Month><Day>30</Day></DateCompleted><DateRevised><Year>2014</Year><Month>12</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0534</ISSN><JournalIssue CitedMedium="Internet"><Volume>55</Volume><PubDate><Year>2014</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Computers in biology and medicine</Title><ISOAbbreviation>Comput. Biol. Med.</ISOAbbreviation></Journal><ArticleTitle>A ternary model of decompression sickness in rats.</ArticleTitle><Pagination><MedlinePgn>74-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.compbiomed.2014.10.012</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0010-4825(14)00286-8</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Decompression sickness (DCS) in rats is commonly modelled as a binary outcome. The present study aimed to develop a ternary model of predicting probability of DCS in rats, (as no-DCS, survivable-DCS or death), based upon the compression/decompression profile and physiological characteristics of each rat.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A literature search identified dive profiles with outcomes no-DCS, survivable-DCS or death by DCS. Inclusion criteria were that at least one rat was represented in each DCS status, not treated with drugs or simulated ascent to altitude, that strain, sex, breathing gases and compression/decompression profile were described and that weight was reported. A dataset was compiled (n=1602 rats) from 15 studies using 22 dive profiles and two strains of both sexes. Inert gas pressures in five compartments were estimated. Using ordinal logistic regression, model-fit of the calibration dataset was optimised by maximum log likelihood. Two validation datasets assessed model robustness.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In the interpolation dataset the model predicted 10/15 cases of nDCS, 3/3 sDCS and 2/2 dDCS, totalling 15/20 (75% accuracy) and 18.5/20 (92.5%) were within 95% confidence intervals. Mean weight in the extrapolation dataset was more than 2SD outside of the calibration dataset and the probability of each outcome was not predictable.</AbstractText><AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">This model is reliable for the prediction of DCS status providing the dive profile and rat characteristics are within the range of parameters used to optimise the model. The addition of data with a wider range of parameters should improve the applicability of the model.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Buzzacott</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Université de Bretagne Occidentale, Laboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, 6 avenue Le Gorgeu, CS 93837, 29200 Brest Cedex 3, France; School of Sports Science, Exercise and Health, the University of Western Australia, 35 Stirling Highway, Crawley WA 6009, Australia. Electronic address: peter.buzzacott@uwa.edu.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lambrechts</LastName><ForeName>Kate</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Université de Bretagne Occidentale, Laboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, 6 avenue Le Gorgeu, CS 93837, 29200 Brest Cedex 3, France. Electronic address: lambrechtskate@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mazur</LastName><ForeName>Aleksandra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Université de Bretagne Occidentale, Laboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, 6 avenue Le Gorgeu, CS 93837, 29200 Brest Cedex 3, France. Electronic address: maz.aleksandra@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Qiong</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Université de Bretagne Occidentale, Laboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, 6 avenue Le Gorgeu, CS 93837, 29200 Brest Cedex 3, France. Electronic address: qiong.wang@etudiant.univ-brest.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Papadopoulou</LastName><ForeName>Virginie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Bioengineering, Imperial College London, London, United Kingdom. Electronic address: virginie.papadopoulou07@imperial.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Theron</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Université de Bretagne Occidentale, Laboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, 6 avenue Le Gorgeu, CS 93837, 29200 Brest Cedex 3, France. Electronic address: Michael.Theron@univ-brest.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balestra</LastName><ForeName>Costantino</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Haute Ecole Paul Henri-Spaak, Environmental, Occupational & Ageing (Integrative) Physiology Laboratory, Brussels, Belgium; DAN Europe Research Division, Brussels, Belgium. Electronic address: daneuben@skynet.be.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guerrero</LastName><ForeName>François</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Université de Bretagne Occidentale, Laboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, 6 avenue Le Gorgeu, CS 93837, 29200 Brest Cedex 3, France. Electronic address: francois.guerrero@univ-brest.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>10</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Comput Biol Med</MedlineTA><NlmUniqueID>1250250</NlmUniqueID><ISSNLinking>0010-4825</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003665" MajorTopicYN="N">Decompression Sickness</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="Y">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Animal model</Keyword><Keyword MajorTopicYN="N">Decompression illness</Keyword><Keyword MajorTopicYN="N">Marginal decompression sickness</Keyword><Keyword MajorTopicYN="N">Modelling</Keyword><Keyword MajorTopicYN="N">Ordinal logistic regression</Keyword><Keyword MajorTopicYN="N">Trinary outcome</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>07</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>10</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>10</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25450221</ArticleId><ArticleId IdType="pii">S0010-4825(14)00286-8</ArticleId><ArticleId IdType="doi">10.1016/j.compbiomed.2014.10.012</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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