Folate pathway gene polymorphisms, maternal folic acid use, and risk of childhood acute lymphoblastic leukemia.
Identifieur interne : 003130 ( PubMed/Corpus ); précédent : 003129; suivant : 003131Folate pathway gene polymorphisms, maternal folic acid use, and risk of childhood acute lymphoblastic leukemia.
Auteurs : Elizabeth Milne ; Kathryn R. Greenop ; Rodney J. Scott ; Michelle Haber ; Murray D. Norris ; John Attia ; Sarra E. Jamieson ; Margaret Miller ; Carol Bower ; Helen D. Bailey ; Somer Dawson ; Geoffrey B. Mccowage ; Nicholas H. De Klerk ; Frank M. Van Bockxmeer ; Bruce K. ArmstrongSource :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [ 1538-7755 ] ; 2015.
English descriptors
- KwdEn :
- Adolescent, Child, Child, Preschool, Dietary Supplements (analysis), Female, Folic Acid (genetics), Genetic Predisposition to Disease, Humans, Infant, Infant, Newborn, Polymorphism, Genetic, Precursor Cell Lymphoblastic Leukemia-Lymphoma (etiology), Precursor Cell Lymphoblastic Leukemia-Lymphoma (genetics), Pregnancy, Risk Factors.
- MESH :
- chemical , genetics : Folic Acid.
- analysis : Dietary Supplements.
- etiology : Precursor Cell Lymphoblastic Leukemia-Lymphoma.
- genetics : Precursor Cell Lymphoblastic Leukemia-Lymphoma.
- Adolescent, Child, Child, Preschool, Female, Genetic Predisposition to Disease, Humans, Infant, Infant, Newborn, Polymorphism, Genetic, Pregnancy, Risk Factors.
Abstract
Several studies suggest that maternal folic acid supplementation before or during pregnancy protects against childhood acute lymphoblastic leukemia (ALL). We investigated associations between ALL risk and folate pathway gene polymorphisms, and their modification by maternal folic acid supplements, in a population-based case-control study (2003-2007).
DOI: 10.1158/1055-9965.EPI-14-0680
PubMed: 25395472
Links to Exploration step
pubmed:25395472Le document en format XML
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Scott</name><affiliation><nlm:affiliation>Hunter Medical Research Institute, John Hunter Hospital, New Lambton, New South Wales, Australia. School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia. Hunter Area Pathology Service, HNEHealth, Newcastle, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Haber, Michelle" sort="Haber, Michelle" uniqKey="Haber M" first="Michelle" last="Haber">Michelle Haber</name><affiliation><nlm:affiliation>Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Norris, Murray D" sort="Norris, Murray D" uniqKey="Norris M" first="Murray D" last="Norris">Murray D. 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Mccowage</name><affiliation><nlm:affiliation>Oncology Unit, The Children's Hospital at Westmead, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="De Klerk, Nicholas H" sort="De Klerk, Nicholas H" uniqKey="De Klerk N" first="Nicholas H" last="De Klerk">Nicholas H. De Klerk</name><affiliation><nlm:affiliation>Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Van Bockxmeer, Frank M" sort="Van Bockxmeer, Frank M" uniqKey="Van Bockxmeer F" first="Frank M" last="Van Bockxmeer">Frank M. Van Bockxmeer</name><affiliation><nlm:affiliation>Department of Clinical Biochemistry, Royal Perth Hospital and the School of Surgery, University of Western Australia, Perth, Western Australia, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K" last="Armstrong">Bruce K. Armstrong</name><affiliation><nlm:affiliation>Sax Institute, Haymarket, New South Wales, Australia. Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25395472</idno><idno type="pmid">25395472</idno><idno type="doi">10.1158/1055-9965.EPI-14-0680</idno><idno type="wicri:Area/PubMed/Corpus">003130</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003130</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Folate pathway gene polymorphisms, maternal folic acid use, and risk of childhood acute lymphoblastic leukemia.</title><author><name sortKey="Milne, Elizabeth" sort="Milne, Elizabeth" uniqKey="Milne E" first="Elizabeth" last="Milne">Elizabeth Milne</name><affiliation><nlm:affiliation>Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia. Liz.Milne@telethonkids.org.au.</nlm:affiliation></affiliation></author><author><name sortKey="Greenop, Kathryn R" sort="Greenop, Kathryn R" uniqKey="Greenop K" first="Kathryn R" last="Greenop">Kathryn R. Greenop</name><affiliation><nlm:affiliation>Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J" last="Scott">Rodney J. Scott</name><affiliation><nlm:affiliation>Hunter Medical Research Institute, John Hunter Hospital, New Lambton, New South Wales, Australia. School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia. Hunter Area Pathology Service, HNEHealth, Newcastle, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Haber, Michelle" sort="Haber, Michelle" uniqKey="Haber M" first="Michelle" last="Haber">Michelle Haber</name><affiliation><nlm:affiliation>Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Norris, Murray D" sort="Norris, Murray D" uniqKey="Norris M" first="Murray D" last="Norris">Murray D. Norris</name><affiliation><nlm:affiliation>Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation><nlm:affiliation>Hunter Medical Research Institute, John Hunter Hospital, New Lambton, New South Wales, Australia. School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Jamieson, Sarra E" sort="Jamieson, Sarra E" uniqKey="Jamieson S" first="Sarra E" last="Jamieson">Sarra E. Jamieson</name><affiliation><nlm:affiliation>Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Miller, Margaret" sort="Miller, Margaret" uniqKey="Miller M" first="Margaret" last="Miller">Margaret Miller</name><affiliation><nlm:affiliation>School of Exercise and Health Sciences, Edith Cowan University, Mount Lawley, Western Australia, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Bower, Carol" sort="Bower, Carol" uniqKey="Bower C" first="Carol" last="Bower">Carol Bower</name><affiliation><nlm:affiliation>Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Bailey, Helen D" sort="Bailey, Helen D" uniqKey="Bailey H" first="Helen D" last="Bailey">Helen D. Bailey</name><affiliation><nlm:affiliation>Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia. Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Dawson, Somer" sort="Dawson, Somer" uniqKey="Dawson S" first="Somer" last="Dawson">Somer Dawson</name><affiliation><nlm:affiliation>Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mccowage, Geoffrey B" sort="Mccowage, Geoffrey B" uniqKey="Mccowage G" first="Geoffrey B" last="Mccowage">Geoffrey B. Mccowage</name><affiliation><nlm:affiliation>Oncology Unit, The Children's Hospital at Westmead, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="De Klerk, Nicholas H" sort="De Klerk, Nicholas H" uniqKey="De Klerk N" first="Nicholas H" last="De Klerk">Nicholas H. De Klerk</name><affiliation><nlm:affiliation>Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Van Bockxmeer, Frank M" sort="Van Bockxmeer, Frank M" uniqKey="Van Bockxmeer F" first="Frank M" last="Van Bockxmeer">Frank M. Van Bockxmeer</name><affiliation><nlm:affiliation>Department of Clinical Biochemistry, Royal Perth Hospital and the School of Surgery, University of Western Australia, Perth, Western Australia, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K" last="Armstrong">Bruce K. Armstrong</name><affiliation><nlm:affiliation>Sax Institute, Haymarket, New South Wales, Australia. Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="eISSN">1538-7755</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Dietary Supplements (analysis)</term><term>Female</term><term>Folic Acid (genetics)</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Polymorphism, Genetic</term><term>Precursor Cell Lymphoblastic Leukemia-Lymphoma (etiology)</term><term>Precursor Cell Lymphoblastic Leukemia-Lymphoma (genetics)</term><term>Pregnancy</term><term>Risk Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Folic Acid</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Dietary Supplements</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Precursor Cell Lymphoblastic Leukemia-Lymphoma</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Precursor Cell Lymphoblastic Leukemia-Lymphoma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Polymorphism, Genetic</term><term>Pregnancy</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several studies suggest that maternal folic acid supplementation before or during pregnancy protects against childhood acute lymphoblastic leukemia (ALL). We investigated associations between ALL risk and folate pathway gene polymorphisms, and their modification by maternal folic acid supplements, in a population-based case-control study (2003-2007).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25395472</PMID><DateCreated><Year>2015</Year><Month>01</Month><Day>14</Day></DateCreated><DateCompleted><Year>2015</Year><Month>09</Month><Day>18</Day></DateCompleted><DateRevised><Year>2015</Year><Month>01</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1538-7755</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>1</Issue><PubDate><Year>2015</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</Title><ISOAbbreviation>Cancer Epidemiol. Biomarkers Prev.</ISOAbbreviation></Journal><ArticleTitle>Folate pathway gene polymorphisms, maternal folic acid use, and risk of childhood acute lymphoblastic leukemia.</ArticleTitle><Pagination><MedlinePgn>48-56</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1158/1055-9965.EPI-14-0680</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Several studies suggest that maternal folic acid supplementation before or during pregnancy protects against childhood acute lymphoblastic leukemia (ALL). We investigated associations between ALL risk and folate pathway gene polymorphisms, and their modification by maternal folic acid supplements, in a population-based case-control study (2003-2007).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">All Australian pediatric oncology centers provided cases; controls were recruited by national random digit dialing. Data from 392 cases and 535 controls were included. Seven folate pathway gene polymorphisms (MTHFR 677C>T, MTHFR 1298A>C, MTRR 66A>G, MTR 2756 A>G, MTR 5049 C>A, CBS 844 Ins68, and CBS 2199 T>C) were genotyped in children and their parents. Information on prepregnancy maternal folic acid supplement use was collected. ORs were estimated with unconditional logistic regression adjusted for frequency-matched variables and potential confounders. Case-parent trios were also analyzed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">There was some evidence of a reduced risk of ALL among children who had, or whose father had, the MTRR 66GG genotype: ORs 0.60 [95% confidence interval (CI) 0.39-0.91] and 0.64 (95% CI, 0.40-1.03), respectively. The ORs for paternal MTHFR 677CT and TT genotypes were 1.41 (95% CI, 1.02-1.93) and 1.81 (95% CI, 1.06-3.07). ORs varied little by maternal folic acid supplementation.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Some folate pathway gene polymorphisms in the child or a parent may influence ALL risk. While biologically plausible, underlying mechanisms for these associations need further elucidation.</AbstractText><AbstractText Label="IMPACT" NlmCategory="CONCLUSIONS">Folate pathway polymorphisms may be related to risk of childhood ALL, but larger studies are needed for conclusive results.</AbstractText><CopyrightInformation>©2014 American Association for Cancer Research.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Milne</LastName><ForeName>Elizabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia. Liz.Milne@telethonkids.org.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Greenop</LastName><ForeName>Kathryn R</ForeName><Initials>KR</Initials><AffiliationInfo><Affiliation>Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scott</LastName><ForeName>Rodney J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Hunter Medical Research Institute, John Hunter Hospital, New Lambton, New South Wales, Australia. School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia. Hunter Area Pathology Service, HNEHealth, Newcastle, New South Wales, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haber</LastName><ForeName>Michelle</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Norris</LastName><ForeName>Murray D</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Attia</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Hunter Medical Research Institute, John Hunter Hospital, New Lambton, New South Wales, Australia. School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jamieson</LastName><ForeName>Sarra E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miller</LastName><ForeName>Margaret</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>School of Exercise and Health Sciences, Edith Cowan University, Mount Lawley, Western Australia, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bower</LastName><ForeName>Carol</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bailey</LastName><ForeName>Helen D</ForeName><Initials>HD</Initials><AffiliationInfo><Affiliation>Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia. Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dawson</LastName><ForeName>Somer</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCowage</LastName><ForeName>Geoffrey B</ForeName><Initials>GB</Initials><AffiliationInfo><Affiliation>Oncology Unit, The Children's Hospital at Westmead, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Klerk</LastName><ForeName>Nicholas H</ForeName><Initials>NH</Initials><AffiliationInfo><Affiliation>Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Bockxmeer</LastName><ForeName>Frank M</ForeName><Initials>FM</Initials><AffiliationInfo><Affiliation>Department of Clinical Biochemistry, Royal Perth Hospital and the School of Surgery, University of Western Australia, Perth, Western Australia, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Armstrong</LastName><ForeName>Bruce K</ForeName><Initials>BK</Initials><AffiliationInfo><Affiliation>Sax Institute, Haymarket, New South Wales, Australia. Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>11</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cancer Epidemiol Biomarkers Prev</MedlineTA><NlmUniqueID>9200608</NlmUniqueID><ISSNLinking>1055-9965</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>935E97BOY8</RegistryNumber><NameOfSubstance UI="D005492">Folic Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019587" MajorTopicYN="N">Dietary Supplements</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005492" MajorTopicYN="N">Folic Acid</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="N">Genetic Predisposition to Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054198" MajorTopicYN="N">Precursor Cell Lymphoblastic Leukemia-Lymphoma</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>11</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>11</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>9</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25395472</ArticleId><ArticleId IdType="pii">1055-9965.EPI-14-0680</ArticleId><ArticleId IdType="doi">10.1158/1055-9965.EPI-14-0680</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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