AustralieFrV1, PubMed, Corpus, bibRecord, 002F23

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.

Identifieur interne : 002F23 ( PubMed/Corpus ); précédent : 002F22; suivant : 002F24

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.

Auteurs : Jessica K. Mountford ; Claire Petitjean ; Harun W Kusuma Putra ; Jonathan A. Mccafferty ; Natasha M. Setiabakti ; Hannah Lee ; Lotte L. T Nnesen ; James D. Mcfadyen ; Simone M. Schoenwaelder ; Anita Eckly ; Christian Gachet ; Sarah Ellis ; Anne K. Voss ; Ross A. Dickins ; Justin R. Hamilton ; Shaun P. Jackson

Source :

Nature communications [ 2041-1723 ] ; 2015.

RBID : pubmed:25779105

English descriptors

KwdEn :
- Alleles, Animals, Blood Platelets (metabolism), Bone Marrow Transplantation, Cell Adhesion, Crosses, Genetic, Gene Expression Regulation, Genotype, Hemostasis, Humans, Mice, Mice, Inbred C57BL, Microscopy, Electron, Transmission, Mutation, Perfusion, Phosphatidylinositol 3-Kinases (metabolism), Phosphorylation, Platelet Adhesiveness, Platelet Aggregation, Shear Strength, Signal Transduction, Stress, Mechanical, Thrombosis (genetics), Thrombosis (metabolism).
MESH :
- chemical , metabolism : Phosphatidylinositol 3-Kinases.
- genetics : Thrombosis.
- metabolism : Blood Platelets, Thrombosis.
- Alleles, Animals, Bone Marrow Transplantation, Cell Adhesion, Crosses, Genetic, Gene Expression Regulation, Genotype, Hemostasis, Humans, Mice, Mice, Inbred C57BL, Microscopy, Electron, Transmission, Mutation, Perfusion, Phosphorylation, Platelet Adhesiveness, Platelet Aggregation, Shear Strength, Signal Transduction, Stress, Mechanical.

Abstract

PI3KC2α is a broadly expressed lipid kinase with critical functions during embryonic development but poorly defined roles in adult physiology. Here we utilize multiple mouse genetic models to uncover a role for PI3KC2α in regulating the internal membrane reserve structure of megakaryocytes (demarcation membrane system) and platelets (open canalicular system) that results in dysregulated platelet adhesion under haemodynamic shear stress. Structural alterations in the platelet internal membrane lead to enhanced membrane tether formation that is associated with accelerated, yet highly unstable, thrombus formation in vitro and in vivo. Notably, agonist-induced 3-phosphorylated phosphoinositide production and cellular activation are normal in PI3KC2α-deficient platelets. These findings demonstrate an important role for PI3KC2α in regulating shear-dependent platelet adhesion via regulation of membrane structure, rather than acute signalling. These studies provide a link between the open canalicular system and platelet adhesive function that has relevance to the primary haemostatic and prothrombotic function of platelets.

DOI: 10.1038/ncomms7535
PubMed: 25779105

Links to Exploration step

pubmed:25779105

Le document en format XML

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<term>Bone Marrow Transplantation</term>
<term>Cell Adhesion</term>
<term>Crosses, Genetic</term>
<term>Gene Expression Regulation</term>
<term>Genotype</term>
<term>Hemostasis</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Microscopy, Electron, Transmission</term>
<term>Mutation</term>
<term>Perfusion</term>
<term>Phosphatidylinositol 3-Kinases (metabolism)</term>
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<term>Signal Transduction</term>
<term>Stress, Mechanical</term>
<term>Thrombosis (genetics)</term>
<term>Thrombosis (metabolism)</term>
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<term>Thrombosis</term>
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<term>Animals</term>
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<term>Crosses, Genetic</term>
<term>Gene Expression Regulation</term>
<term>Genotype</term>
<term>Hemostasis</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Microscopy, Electron, Transmission</term>
<term>Mutation</term>
<term>Perfusion</term>
<term>Phosphorylation</term>
<term>Platelet Adhesiveness</term>
<term>Platelet Aggregation</term>
<term>Shear Strength</term>
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<front><div type="abstract" xml:lang="en">PI3KC2α is a broadly expressed lipid kinase with critical functions during embryonic development but poorly defined roles in adult physiology. Here we utilize multiple mouse genetic models to uncover a role for PI3KC2α in regulating the internal membrane reserve structure of megakaryocytes (demarcation membrane system) and platelets (open canalicular system) that results in dysregulated platelet adhesion under haemodynamic shear stress. Structural alterations in the platelet internal membrane lead to enhanced membrane tether formation that is associated with accelerated, yet highly unstable, thrombus formation in vitro and in vivo. Notably, agonist-induced 3-phosphorylated phosphoinositide production and cellular activation are normal in PI3KC2α-deficient platelets. These findings demonstrate an important role for PI3KC2α in regulating shear-dependent platelet adhesion via regulation of membrane structure, rather than acute signalling. These studies provide a link between the open canalicular system and platelet adhesive function that has relevance to the primary haemostatic and prothrombotic function of platelets.</div>
</front>
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<Abstract><AbstractText>PI3KC2α is a broadly expressed lipid kinase with critical functions during embryonic development but poorly defined roles in adult physiology. Here we utilize multiple mouse genetic models to uncover a role for PI3KC2α in regulating the internal membrane reserve structure of megakaryocytes (demarcation membrane system) and platelets (open canalicular system) that results in dysregulated platelet adhesion under haemodynamic shear stress. Structural alterations in the platelet internal membrane lead to enhanced membrane tether formation that is associated with accelerated, yet highly unstable, thrombus formation in vitro and in vivo. Notably, agonist-induced 3-phosphorylated phosphoinositide production and cellular activation are normal in PI3KC2α-deficient platelets. These findings demonstrate an important role for PI3KC2α in regulating shear-dependent platelet adhesion via regulation of membrane structure, rather than acute signalling. These studies provide a link between the open canalicular system and platelet adhesive function that has relevance to the primary haemostatic and prothrombotic function of platelets.</AbstractText>
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<Initials>JR</Initials>
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</AffiliationInfo>
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<AffiliationInfo><Affiliation>1] Australian Centre for Blood Diseases, Monash University, Level 6, 89 Commercial Road, Melbourne, Victoria 3004, Australia [2] The Heart Research Institute and Charles Perkins Centre, The University of Sydney, Newtown 2050, Australia [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, San Diego, CA 92037, USA.</Affiliation>
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   |texte=   The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.
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	Serveur d'exploration sur les relations entre la France et l'Australie
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The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.

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