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Circulating prolactin and in situ breast cancer risk in the European EPIC cohort: a case-control study.

Identifieur interne : 002F07 ( PubMed/Corpus ); précédent : 002F06; suivant : 002F08

Circulating prolactin and in situ breast cancer risk in the European EPIC cohort: a case-control study.

Auteurs : Kaja Tikk ; Disorn Sookthai ; Renée T. Fortner ; Theron Johnson ; Sabina Rinaldi ; Isabelle Romieu ; Anne Tj Nneland ; Anja Olsen ; Kim Overvad ; Françoise Clavel-Chapelon ; Laura Baglietto ; Heiner Boeing ; Antonia Trichopoulou ; Pagona Lagiou ; Dimitrios Trichopoulos ; Giovanna Masala ; Vittorio Krogh ; Rosario Tumino ; Fulvio Ricceri ; Amalia Mattiello ; Antonio Agudo ; Virginia Menéndez ; María-José Sánchez ; Pilar Amiano ; Maria-Dolores Chirlaque ; Aurelio Barricarte ; H Bas Bueno-De-Mesquita ; Evelyn M. Monninkhof ; N Charlotte Onland-Moret ; Anne Andresson ; Malin Sund ; Elisabete Weiderpass ; Kay-Tee Khaw ; Timothy J. Key ; Ruth C. Travis ; Melissa A. Merritt ; Elio Riboli ; Laure Dossus ; Rudolf Kaaks

Source :

RBID : pubmed:25887963

English descriptors

Abstract

The relationship between circulating prolactin and invasive breast cancer has been investigated previously, but the association between prolactin levels and in situ breast cancer risk has received less attention.

DOI: 10.1186/s13058-015-0563-6
PubMed: 25887963

Links to Exploration step

pubmed:25887963

Le document en format XML

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<name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name>
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<name sortKey="Barricarte, Aurelio" sort="Barricarte, Aurelio" uniqKey="Barricarte A" first="Aurelio" last="Barricarte">Aurelio Barricarte</name>
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<name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name>
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<name sortKey="Andresson, Anne" sort="Andresson, Anne" uniqKey="Andresson A" first="Anne" last="Andresson">Anne Andresson</name>
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<nlm:affiliation>Department of Radiation Sciences, University of Umeå, Umeå, Sweden. anne.andersson@onkologi.umu.se.</nlm:affiliation>
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<name sortKey="Sund, Malin" sort="Sund, Malin" uniqKey="Sund M" first="Malin" last="Sund">Malin Sund</name>
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<nlm:affiliation>Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden. malin.sund@surgery.umu.se.</nlm:affiliation>
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<name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name>
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<nlm:affiliation>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway. Elisabete.Weiderpass.Vainio@ki.se.</nlm:affiliation>
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<nlm:affiliation>School of Clinical Medicine, University of Cambridge, Cambridge, UK. kk101@medschl.cam.ac.uk.</nlm:affiliation>
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<nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. ruth.travis@ceu.ox.ac.uk.</nlm:affiliation>
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<name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name>
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<nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College, London, UK. e.riboli@imperial.ac.uk.</nlm:affiliation>
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<nlm:affiliation>INSERM, Centre for Research in Epidemiology and Population Health [CESP], U1018, Nutrition, Hormones and Women's Health team, F-94805, Villejuif, France. laure.dossus@lyon.unicancer.fr.</nlm:affiliation>
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<nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. r.kaaks@dkfz.de.</nlm:affiliation>
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<title xml:lang="en">Circulating prolactin and in situ breast cancer risk in the European EPIC cohort: a case-control study.</title>
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<name sortKey="Tikk, Kaja" sort="Tikk, Kaja" uniqKey="Tikk K" first="Kaja" last="Tikk">Kaja Tikk</name>
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<nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. k.tikk@dkfz.de.</nlm:affiliation>
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<nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. d.sookthai@dkfz-heidelberg.de.</nlm:affiliation>
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<name sortKey="Fortner, Renee T" sort="Fortner, Renee T" uniqKey="Fortner R" first="Renée T" last="Fortner">Renée T. Fortner</name>
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<nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. r.fortner@dkfz-heidelberg.de.</nlm:affiliation>
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<name sortKey="Johnson, Theron" sort="Johnson, Theron" uniqKey="Johnson T" first="Theron" last="Johnson">Theron Johnson</name>
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<nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. t.johnson@dkfz-heidelberg.de.</nlm:affiliation>
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<name sortKey="Rinaldi, Sabina" sort="Rinaldi, Sabina" uniqKey="Rinaldi S" first="Sabina" last="Rinaldi">Sabina Rinaldi</name>
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<nlm:affiliation>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France. RinaldiS@iarc.fr.</nlm:affiliation>
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<name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name>
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<nlm:affiliation>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France. romieui@iarc.fr.</nlm:affiliation>
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<name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name>
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<nlm:affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark. annet@cancer.dk.</nlm:affiliation>
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<name sortKey="Olsen, Anja" sort="Olsen, Anja" uniqKey="Olsen A" first="Anja" last="Olsen">Anja Olsen</name>
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<nlm:affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark. anja@cancer.dk.</nlm:affiliation>
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<name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name>
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<nlm:affiliation>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark. ko@soci.au.dk.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Clavel Chapelon, Francoise" sort="Clavel Chapelon, Francoise" uniqKey="Clavel Chapelon F" first="Françoise" last="Clavel-Chapelon">Françoise Clavel-Chapelon</name>
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<nlm:affiliation>INSERM, Centre for Research in Epidemiology and Population Health [CESP], U1018, Nutrition, Hormones and Women's Health team, F-94805, Villejuif, France. francoise.clavel@igr.fr.</nlm:affiliation>
</affiliation>
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<name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
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<nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, 3053, Melbourne, Australia. Laura.Baglietto@cancervic.org.au.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name>
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<nlm:affiliation>Department of Epidemiology, German Institute of Human Nutrition (DIfE) Potsdam-Rehbrücke, Nuthetal, Germany. boeing@dife.de.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name>
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<nlm:affiliation>Hellenic Health Foundation, 13 Kaisareias Street, GR-115 27, Athens, Greece. atrichopoulou@hhf-greece.gr.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name>
<affiliation>
<nlm:affiliation>Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 M. Asias Street, Goudi, GR-115 27, Athens, Greece. pdlagiou@med.uoa.gr.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name>
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<nlm:affiliation>Hellenic Health Foundation, 13 Kaisareias Street, GR-115 27, Athens, Greece. dtrichop@hsph.harvard.edu.</nlm:affiliation>
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<author>
<name sortKey="Masala, Giovanna" sort="Masala, Giovanna" uniqKey="Masala G" first="Giovanna" last="Masala">Giovanna Masala</name>
<affiliation>
<nlm:affiliation>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy. g.masala@ispo.toscana.it.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name>
<affiliation>
<nlm:affiliation>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milano, Italy. vittorio.krogh@istitutotumori.mi.it.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name>
<affiliation>
<nlm:affiliation>Cancer Registry and Histopathology Unit, "Civic - M.P.Arezzo" Hospital ASP, Ragusa, Italy. rtumino@tin.it.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Ricceri, Fulvio" sort="Ricceri, Fulvio" uniqKey="Ricceri F" first="Fulvio" last="Ricceri">Fulvio Ricceri</name>
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<nlm:affiliation>Unit of Cancer Epidemiology, AO Citta' della Salute e della Scienza, University of Turin, Torino, Italy. fulvio.ricceri@gmail.com.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Mattiello, Amalia" sort="Mattiello, Amalia" uniqKey="Mattiello A" first="Amalia" last="Mattiello">Amalia Mattiello</name>
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<nlm:affiliation>Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. amattiel@unina.it.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Agudo, Antonio" sort="Agudo, Antonio" uniqKey="Agudo A" first="Antonio" last="Agudo">Antonio Agudo</name>
<affiliation>
<nlm:affiliation>Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology-ICO, IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08908, Spain. a.agudo@iconcologia.net.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Menendez, Virginia" sort="Menendez, Virginia" uniqKey="Menendez V" first="Virginia" last="Menéndez">Virginia Menéndez</name>
<affiliation>
<nlm:affiliation>Public Health Directorate, Asturias, Spain. virginia.menendezgarcia@asturias.org.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="María-José" last="Sánchez">María-José Sánchez</name>
<affiliation>
<nlm:affiliation>Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitario de Granada (Granada.ibs), Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain. mariajose.sanchez.easp@juntadeandalucia.es.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Amiano, Pilar" sort="Amiano, Pilar" uniqKey="Amiano P" first="Pilar" last="Amiano">Pilar Amiano</name>
<affiliation>
<nlm:affiliation>Public Health Division of Gipuzkoa, BioDonostia Reserach Institute, San Sebastian, Spain. epicss-san@ej-gv.es.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Chirlaque, Maria Dolores" sort="Chirlaque, Maria Dolores" uniqKey="Chirlaque M" first="Maria-Dolores" last="Chirlaque">Maria-Dolores Chirlaque</name>
<affiliation>
<nlm:affiliation>Department of Epidemiology, Murcia Regional Health Authority, Murcia, Spain. mdolores.chirlaque@carm.es.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Barricarte, Aurelio" sort="Barricarte, Aurelio" uniqKey="Barricarte A" first="Aurelio" last="Barricarte">Aurelio Barricarte</name>
<affiliation>
<nlm:affiliation>Navarre Public Health Institute, Pamplona, Spain. abarricg@cfnavarra.es.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name>
<affiliation>
<nlm:affiliation>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. abarricg@cfnavarra.es.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Monninkhof, Evelyn M" sort="Monninkhof, Evelyn M" uniqKey="Monninkhof E" first="Evelyn M" last="Monninkhof">Evelyn M. Monninkhof</name>
<affiliation>
<nlm:affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. E.Monninkhof@umcutrecht.nl.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name>
<affiliation>
<nlm:affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. N.C.Onland@umcutrecht.nl.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Andresson, Anne" sort="Andresson, Anne" uniqKey="Andresson A" first="Anne" last="Andresson">Anne Andresson</name>
<affiliation>
<nlm:affiliation>Department of Radiation Sciences, University of Umeå, Umeå, Sweden. anne.andersson@onkologi.umu.se.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Sund, Malin" sort="Sund, Malin" uniqKey="Sund M" first="Malin" last="Sund">Malin Sund</name>
<affiliation>
<nlm:affiliation>Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden. malin.sund@surgery.umu.se.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name>
<affiliation>
<nlm:affiliation>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway. Elisabete.Weiderpass.Vainio@ki.se.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name>
<affiliation>
<nlm:affiliation>School of Clinical Medicine, University of Cambridge, Cambridge, UK. kk101@medschl.cam.ac.uk.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J" last="Key">Timothy J. Key</name>
<affiliation>
<nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. tim.key@ceu.ox.ac.uk.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name>
<affiliation>
<nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. ruth.travis@ceu.ox.ac.uk.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Merritt, Melissa A" sort="Merritt, Melissa A" uniqKey="Merritt M" first="Melissa A" last="Merritt">Melissa A. Merritt</name>
<affiliation>
<nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College, London, UK. m.merritt@imperial.ac.uk.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name>
<affiliation>
<nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College, London, UK. e.riboli@imperial.ac.uk.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Dossus, Laure" sort="Dossus, Laure" uniqKey="Dossus L" first="Laure" last="Dossus">Laure Dossus</name>
<affiliation>
<nlm:affiliation>INSERM, Centre for Research in Epidemiology and Population Health [CESP], U1018, Nutrition, Hormones and Women's Health team, F-94805, Villejuif, France. laure.dossus@lyon.unicancer.fr.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. r.kaaks@dkfz.de.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Breast cancer research : BCR</title>
<idno type="eISSN">1465-542X</idno>
<imprint>
<date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
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<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Adult</term>
<term>Aged</term>
<term>Breast Neoplasms (blood)</term>
<term>Breast Neoplasms (epidemiology)</term>
<term>Breast Neoplasms (pathology)</term>
<term>Carcinoma in Situ (blood)</term>
<term>Case-Control Studies</term>
<term>Cohort Studies</term>
<term>Europe (epidemiology)</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Logistic Models</term>
<term>Menopause</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Prolactin (blood)</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en">
<term>Prolactin</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en">
<term>Europe</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en">
<term>Breast Neoplasms</term>
<term>Carcinoma in Situ</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Aged</term>
<term>Case-Control Studies</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Logistic Models</term>
<term>Menopause</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Risk Factors</term>
</keywords>
</textClass>
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</teiHeader>
<front>
<div type="abstract" xml:lang="en">The relationship between circulating prolactin and invasive breast cancer has been investigated previously, but the association between prolactin levels and in situ breast cancer risk has received less attention.</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="MEDLINE" Owner="NLM">
<PMID Version="1">25887963</PMID>
<DateCreated>
<Year>2015</Year>
<Month>04</Month>
<Day>30</Day>
</DateCreated>
<DateCompleted>
<Year>2016</Year>
<Month>01</Month>
<Day>15</Day>
</DateCompleted>
<DateRevised>
<Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Electronic">
<Journal>
<ISSN IssnType="Electronic">1465-542X</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>17</Volume>
<PubDate>
<Year>2015</Year>
<Month>Mar</Month>
<Day>31</Day>
</PubDate>
</JournalIssue>
<Title>Breast cancer research : BCR</Title>
<ISOAbbreviation>Breast Cancer Res.</ISOAbbreviation>
</Journal>
<ArticleTitle>Circulating prolactin and in situ breast cancer risk in the European EPIC cohort: a case-control study.</ArticleTitle>
<Pagination>
<MedlinePgn>49</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s13058-015-0563-6</ELocationID>
<Abstract>
<AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">The relationship between circulating prolactin and invasive breast cancer has been investigated previously, but the association between prolactin levels and in situ breast cancer risk has received less attention.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We analysed the relationship between pre-diagnostic prolactin levels and the risk of in situ breast cancer overall, and by menopausal status and use of postmenopausal hormone therapy (HT) at blood donation. Conditional logistic regression was used to assess this association in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, including 307 in situ breast cancer cases and their matched control subjects.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">We found a significant positive association between higher circulating prolactin levels and risk of in situ breast cancer among all women [pre-and postmenopausal combined, ORlog2=1.35 (95% CI 1.04-1.76), Ptrend=0.03]. No statistically significant heterogeneity was found between prolactin levels and in situ cancer risk by menopausal status (Phet=0.98) or baseline HT use (Phet=0.20), although the observed association was more pronounced among postmenopausal women using HT compared to non-users (Ptrend=0.06 vs Ptrend=0.35). In subgroup analyses, the observed positive association was strongest in women diagnosed with in situ breast tumors<4 years compared to ≥4 years after blood donation (Ptrend=0.01 vs Ptrend=0.63; Phet=0.04) and among nulliparous women compared to parous women (Ptrend=0.03 vs Ptrend=0.15; Phet=0.07).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our data extends prior research linking prolactin and invasive breast cancer to the outcome of in situ breast tumours and shows that higher circulating prolactin is associated with increased risk of in situ breast cancer.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Tikk</LastName>
<ForeName>Kaja</ForeName>
<Initials>K</Initials>
<AffiliationInfo>
<Affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. k.tikk@dkfz.de.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ) Heidelberg, Im Neuenheimer Feld 581, D-69120, Heidelberg, Germany. k.tikk@dkfz.de.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Sookthai</LastName>
<ForeName>Disorn</ForeName>
<Initials>D</Initials>
<AffiliationInfo>
<Affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. d.sookthai@dkfz-heidelberg.de.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Fortner</LastName>
<ForeName>Renée T</ForeName>
<Initials>RT</Initials>
<AffiliationInfo>
<Affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. r.fortner@dkfz-heidelberg.de.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Johnson</LastName>
<ForeName>Theron</ForeName>
<Initials>T</Initials>
<AffiliationInfo>
<Affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. t.johnson@dkfz-heidelberg.de.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Rinaldi</LastName>
<ForeName>Sabina</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France. RinaldiS@iarc.fr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Romieu</LastName>
<ForeName>Isabelle</ForeName>
<Initials>I</Initials>
<AffiliationInfo>
<Affiliation>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France. romieui@iarc.fr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Tjønneland</LastName>
<ForeName>Anne</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark. annet@cancer.dk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Olsen</LastName>
<ForeName>Anja</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark. anja@cancer.dk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Overvad</LastName>
<ForeName>Kim</ForeName>
<Initials>K</Initials>
<AffiliationInfo>
<Affiliation>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark. ko@soci.au.dk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Clavel-Chapelon</LastName>
<ForeName>Françoise</ForeName>
<Initials>F</Initials>
<AffiliationInfo>
<Affiliation>INSERM, Centre for Research in Epidemiology and Population Health [CESP], U1018, Nutrition, Hormones and Women's Health team, F-94805, Villejuif, France. francoise.clavel@igr.fr.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>University Paris Sud, UMRS 1018, F-94805, Villejuif, France. francoise.clavel@igr.fr.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>IGR, F-94805, Villejuif, France. francoise.clavel@igr.fr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Baglietto</LastName>
<ForeName>Laura</ForeName>
<Initials>L</Initials>
<AffiliationInfo>
<Affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, 3053, Melbourne, Australia. Laura.Baglietto@cancervic.org.au.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, 3010, Melbourne, Australia. Laura.Baglietto@cancervic.org.au.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Boeing</LastName>
<ForeName>Heiner</ForeName>
<Initials>H</Initials>
<AffiliationInfo>
<Affiliation>Department of Epidemiology, German Institute of Human Nutrition (DIfE) Potsdam-Rehbrücke, Nuthetal, Germany. boeing@dife.de.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Trichopoulou</LastName>
<ForeName>Antonia</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Hellenic Health Foundation, 13 Kaisareias Street, GR-115 27, Athens, Greece. atrichopoulou@hhf-greece.gr.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 M. Asias Street, Goudi, GR-115 27, Athens, Greece. atrichopoulou@hhf-greece.gr.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens, GR-115 27, Greece. atrichopoulou@hhf-greece.gr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Lagiou</LastName>
<ForeName>Pagona</ForeName>
<Initials>P</Initials>
<AffiliationInfo>
<Affiliation>Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 M. Asias Street, Goudi, GR-115 27, Athens, Greece. pdlagiou@med.uoa.gr.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens, GR-115 27, Greece. pdlagiou@med.uoa.gr.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, USA. pdlagiou@med.uoa.gr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Trichopoulos</LastName>
<ForeName>Dimitrios</ForeName>
<Initials>D</Initials>
<AffiliationInfo>
<Affiliation>Hellenic Health Foundation, 13 Kaisareias Street, GR-115 27, Athens, Greece. dtrichop@hsph.harvard.edu.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens, GR-115 27, Greece. dtrichop@hsph.harvard.edu.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, USA. dtrichop@hsph.harvard.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Masala</LastName>
<ForeName>Giovanna</ForeName>
<Initials>G</Initials>
<AffiliationInfo>
<Affiliation>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy. g.masala@ispo.toscana.it.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Krogh</LastName>
<ForeName>Vittorio</ForeName>
<Initials>V</Initials>
<AffiliationInfo>
<Affiliation>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milano, Italy. vittorio.krogh@istitutotumori.mi.it.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Tumino</LastName>
<ForeName>Rosario</ForeName>
<Initials>R</Initials>
<AffiliationInfo>
<Affiliation>Cancer Registry and Histopathology Unit, "Civic - M.P.Arezzo" Hospital ASP, Ragusa, Italy. rtumino@tin.it.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Ricceri</LastName>
<ForeName>Fulvio</ForeName>
<Initials>F</Initials>
<AffiliationInfo>
<Affiliation>Unit of Cancer Epidemiology, AO Citta' della Salute e della Scienza, University of Turin, Torino, Italy. fulvio.ricceri@gmail.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Center for Cancer Prevention (CPO), Via Santena 7, 10126, Torino, Italy. fulvio.ricceri@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Mattiello</LastName>
<ForeName>Amalia</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. amattiel@unina.it.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Agudo</LastName>
<ForeName>Antonio</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology-ICO, IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08908, Spain. a.agudo@iconcologia.net.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Menéndez</LastName>
<ForeName>Virginia</ForeName>
<Initials>V</Initials>
<AffiliationInfo>
<Affiliation>Public Health Directorate, Asturias, Spain. virginia.menendezgarcia@asturias.org.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Sánchez</LastName>
<ForeName>María-José</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo>
<Affiliation>Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitario de Granada (Granada.ibs), Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain. mariajose.sanchez.easp@juntadeandalucia.es.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Consortium for Biomedical Research in Epidemiology and Public Health (CIBER de Epidemiología y Salud Pública (CIBERESP)), Madrid, Spain. mariajose.sanchez.easp@juntadeandalucia.es.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Amiano</LastName>
<ForeName>Pilar</ForeName>
<Initials>P</Initials>
<AffiliationInfo>
<Affiliation>Public Health Division of Gipuzkoa, BioDonostia Reserach Institute, San Sebastian, Spain. epicss-san@ej-gv.es.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Consortium for Biomedical Research in Epidemiology and Public Health (CIBER de Epidemiología y Salud Pública (CIBERESP)), Madrid, Spain. epicss-san@ej-gv.es.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Chirlaque</LastName>
<ForeName>Maria-Dolores</ForeName>
<Initials>MD</Initials>
<AffiliationInfo>
<Affiliation>Department of Epidemiology, Murcia Regional Health Authority, Murcia, Spain. mdolores.chirlaque@carm.es.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Consortium for Biomedical Research in Epidemiology and Public Health (CIBER de Epidemiología y Salud Pública (CIBERESP)), Madrid, Spain. mdolores.chirlaque@carm.es.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Barricarte</LastName>
<ForeName>Aurelio</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Navarre Public Health Institute, Pamplona, Spain. abarricg@cfnavarra.es.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Consortium for Biomedical Research in Epidemiology and Public Health (CIBER de Epidemiología y Salud Pública (CIBERESP)), Madrid, Spain. abarricg@cfnavarra.es.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Bueno-de-Mesquita</LastName>
<ForeName>H Bas</ForeName>
<Initials>HB</Initials>
<AffiliationInfo>
<Affiliation>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. abarricg@cfnavarra.es.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands. abarricg@cfnavarra.es.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College, London, UK. abarricg@cfnavarra.es.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. abarricg@cfnavarra.es.</Affiliation>
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</Author>
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