Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults.
Identifieur interne : 002E81 ( PubMed/Corpus ); précédent : 002E80; suivant : 002E82Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults.
Auteurs : E. Zimmermann ; L H Ngquist ; S S Mirza ; J H Zhao ; D I Chasman ; K. Fischer ; Q. Qi ; A V Smith ; M. Thinggaard ; M N Jarczok ; M A Nalls ; S. Trompet ; N J Timpson ; B. Schmidt ; A U Jackson ; L P Lyytik Inen ; N. Verweij ; M. Mueller-Nurasyid ; M. Vikström ; P. Marques-Vidal ; A. Wong ; K. Meidtner ; R P Middelberg ; R J Strawbridge ; L. Christiansen ; K O Kyvik ; A. Hamsten ; T. J Skel Inen ; A. Tj Nneland ; J G Eriksson ; J B Whitfield ; H. Boeing ; R. Hardy ; P. Vollenweider ; K. Leander ; A. Peters ; P. Van Der Harst ; M. Kumari ; T. Lehtim Ki ; A. Meirhaeghe ; J. Tuomilehto ; K-H Jöckel ; Y. Ben-Shlomo ; N. Sattar ; S E Baumeister ; G Davey Smith ; J P Casas ; D K Houston ; W. M Rz ; K. Christensen ; V. Gudnason ; F B Hu ; A. Metspalu ; P M Ridker ; N J Wareham ; R J F. Loos ; H. Tiemeier ; E. Sonestedt ; T I A. S RensenSource :
- Obesity reviews : an official journal of the International Association for the Study of Obesity [ 1467-789X ] ; 2015.
English descriptors
- KwdEn :
- Adiposity (genetics), Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Body Mass Index, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Obesity (genetics), Obesity (mortality), Observational Studies as Topic, Polymorphism, Single Nucleotide, Proteins (genetics), Waist Circumference.
- MESH :
- chemical , genetics : Proteins.
- chemical : Alpha-Ketoglutarate-Dependent Dioxygenase FTO.
- genetics : Adiposity, Obesity.
- mortality : Obesity.
- Body Mass Index, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Observational Studies as Topic, Polymorphism, Single Nucleotide, Waist Circumference.
Abstract
Previously, a single nucleotide polymorphism (SNP), rs9939609, in the FTO gene showed a much stronger association with all-cause mortality than expected from its association with body mass index (BMI), body fat mass index (FMI) and waist circumference (WC). This finding implies that the SNP has strong pleiotropic effects on adiposity and adiposity-independent pathological pathways that leads to increased mortality. To investigate this further, we conducted a meta-analysis of similar data from 34 longitudinal studies including 169,551 adult Caucasians among whom 27,100 died during follow-up. Linear regression showed that the minor allele of the FTO SNP was associated with greater BMI (n = 169,551; 0.32 kg m(-2) ; 95% CI 0.28-0.32, P < 1 × 10(-32) ), WC (n = 152,631; 0.76 cm; 0.68-0.84, P < 1 × 10(-32) ) and FMI (n = 48,192; 0.17 kg m(-2) ; 0.13-0.22, P = 1.0 × 10(-13) ). Cox proportional hazard regression analyses for mortality showed that the hazards ratio (HR) for the minor allele of the FTO SNPs was 1.02 (1.00-1.04, P = 0.097), but the apparent excess risk was eliminated after adjustment for BMI and WC (HR: 1.00; 0.98-1.03, P = 0.662) and for FMI (HR: 1.00; 0.96-1.04, P = 0.932). In conclusion, this study does not support that the FTO SNP is associated with all-cause mortality independently of the adiposity phenotypes.
DOI: 10.1111/obr.12263
PubMed: 25752329
Links to Exploration step
pubmed:25752329Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults.</title><author><name sortKey="Zimmermann, E" sort="Zimmermann, E" uniqKey="Zimmermann E" first="E" last="Zimmermann">E. Zimmermann</name><affiliation><nlm:affiliation>Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey=" Ngquist, L H" sort=" Ngquist, L H" uniqKey=" Ngquist L" first="L H" last=" Ngquist">L H Ngquist</name><affiliation><nlm:affiliation>Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Mirza, S S" sort="Mirza, S S" uniqKey="Mirza S" first="S S" last="Mirza">S S Mirza</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, J H" sort="Zhao, J H" uniqKey="Zhao J" first="J H" last="Zhao">J H Zhao</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Chasman, D I" sort="Chasman, D I" uniqKey="Chasman D" first="D I" last="Chasman">D I Chasman</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Fischer, K" sort="Fischer, K" uniqKey="Fischer K" first="K" last="Fischer">K. Fischer</name><affiliation><nlm:affiliation>Estonian Genome Center, University of Tartu, Tartu, Estonia.</nlm:affiliation></affiliation></author><author><name sortKey="Qi, Q" sort="Qi, Q" uniqKey="Qi Q" first="Q" last="Qi">Q. Qi</name><affiliation><nlm:affiliation>Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, A V" sort="Smith, A V" uniqKey="Smith A" first="A V" last="Smith">A V Smith</name><affiliation><nlm:affiliation>Icelandic Heart Association, Kopavogur, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Thinggaard, M" sort="Thinggaard, M" uniqKey="Thinggaard M" first="M" last="Thinggaard">M. Thinggaard</name><affiliation><nlm:affiliation>The Danish Aging Research Center and The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Jarczok, M N" sort="Jarczok, M N" uniqKey="Jarczok M" first="M N" last="Jarczok">M N Jarczok</name><affiliation><nlm:affiliation>Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Nalls, M A" sort="Nalls, M A" uniqKey="Nalls M" first="M A" last="Nalls">M A Nalls</name><affiliation><nlm:affiliation>Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Trompet, S" sort="Trompet, S" uniqKey="Trompet S" first="S" last="Trompet">S. Trompet</name><affiliation><nlm:affiliation>Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Timpson, N J" sort="Timpson, N J" uniqKey="Timpson N" first="N J" last="Timpson">N J Timpson</name><affiliation><nlm:affiliation>MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Schmidt, B" sort="Schmidt, B" uniqKey="Schmidt B" first="B" last="Schmidt">B. Schmidt</name><affiliation><nlm:affiliation>Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jackson, A U" sort="Jackson, A U" uniqKey="Jackson A" first="A U" last="Jackson">A U Jackson</name><affiliation><nlm:affiliation>Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lyytik Inen, L P" sort="Lyytik Inen, L P" uniqKey="Lyytik Inen L" first="L P" last="Lyytik Inen">L P Lyytik Inen</name><affiliation><nlm:affiliation>Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Verweij, N" sort="Verweij, N" uniqKey="Verweij N" first="N" last="Verweij">N. Verweij</name><affiliation><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Mueller Nurasyid, M" sort="Mueller Nurasyid, M" uniqKey="Mueller Nurasyid M" first="M" last="Mueller-Nurasyid">M. Mueller-Nurasyid</name><affiliation><nlm:affiliation>Department of Medicine I, Ludwig-Maximilians-University, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Vikstrom, M" sort="Vikstrom, M" uniqKey="Vikstrom M" first="M" last="Vikström">M. Vikström</name><affiliation><nlm:affiliation>Karolinska Institutet, Institute of Environmental Medicine, Unit of Cardiovascular Epidemiology, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Marques Vidal, P" sort="Marques Vidal, P" uniqKey="Marques Vidal P" first="P" last="Marques-Vidal">P. Marques-Vidal</name><affiliation><nlm:affiliation>Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Wong, A" sort="Wong, A" uniqKey="Wong A" first="A" last="Wong">A. Wong</name><affiliation><nlm:affiliation>MRC Unit for Lifelong Health and Ageing, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Meidtner, K" sort="Meidtner, K" uniqKey="Meidtner K" first="K" last="Meidtner">K. Meidtner</name><affiliation><nlm:affiliation>Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Middelberg, R P" sort="Middelberg, R P" uniqKey="Middelberg R" first="R P" last="Middelberg">R P Middelberg</name><affiliation><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Strawbridge, R J" sort="Strawbridge, R J" uniqKey="Strawbridge R" first="R J" last="Strawbridge">R J Strawbridge</name><affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Christiansen, L" sort="Christiansen, L" uniqKey="Christiansen L" first="L" last="Christiansen">L. Christiansen</name><affiliation><nlm:affiliation>The Danish Aging Research Center and The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Kyvik, K O" sort="Kyvik, K O" uniqKey="Kyvik K" first="K O" last="Kyvik">K O Kyvik</name><affiliation><nlm:affiliation>Institute of Regional Health Services Research and Odense Patient data Explorative Network, Odense University Hospital, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Hamsten, A" sort="Hamsten, A" uniqKey="Hamsten A" first="A" last="Hamsten">A. Hamsten</name><affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="J Skel Inen, T" sort="J Skel Inen, T" uniqKey="J Skel Inen T" first="T" last="J Skel Inen">T. J Skel Inen</name><affiliation><nlm:affiliation>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Tj Nneland, A" sort="Tj Nneland, A" uniqKey="Tj Nneland A" first="A" last="Tj Nneland">A. Tj Nneland</name><affiliation><nlm:affiliation>Danish Cancer Society Research Centre, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Eriksson, J G" sort="Eriksson, J G" uniqKey="Eriksson J" first="J G" last="Eriksson">J G Eriksson</name><affiliation><nlm:affiliation>Diabetes Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Whitfield, J B" sort="Whitfield, J B" uniqKey="Whitfield J" first="J B" last="Whitfield">J B Whitfield</name><affiliation><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Boeing, H" sort="Boeing, H" uniqKey="Boeing H" first="H" last="Boeing">H. Boeing</name><affiliation><nlm:affiliation>Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hardy, R" sort="Hardy, R" uniqKey="Hardy R" first="R" last="Hardy">R. Hardy</name><affiliation><nlm:affiliation>MRC Unit for Lifelong Health and Ageing, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Vollenweider, P" sort="Vollenweider, P" uniqKey="Vollenweider P" first="P" last="Vollenweider">P. Vollenweider</name><affiliation><nlm:affiliation>Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Leander, K" sort="Leander, K" uniqKey="Leander K" first="K" last="Leander">K. Leander</name><affiliation><nlm:affiliation>Karolinska Institutet, Institute of Environmental Medicine, Unit of Cardiovascular Epidemiology, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Peters, A" sort="Peters, A" uniqKey="Peters A" first="A" last="Peters">A. Peters</name><affiliation><nlm:affiliation>Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK), Partner site Munich Heart Alliance, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Harst, P" sort="Van Der Harst, P" uniqKey="Van Der Harst P" first="P" last="Van Der Harst">P. Van Der Harst</name><affiliation><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Kumari, M" sort="Kumari, M" uniqKey="Kumari M" first="M" last="Kumari">M. Kumari</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lehtim Ki, T" sort="Lehtim Ki, T" uniqKey="Lehtim Ki T" first="T" last="Lehtim Ki">T. Lehtim Ki</name><affiliation><nlm:affiliation>Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Meirhaeghe, A" sort="Meirhaeghe, A" uniqKey="Meirhaeghe A" first="A" last="Meirhaeghe">A. Meirhaeghe</name><affiliation><nlm:affiliation>Inserm, U744, Institut Pasteur de Lille, University Lille Nord de France, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tuomilehto, J" sort="Tuomilehto, J" uniqKey="Tuomilehto J" first="J" last="Tuomilehto">J. Tuomilehto</name><affiliation><nlm:affiliation>Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Jockel, K H" sort="Jockel, K H" uniqKey="Jockel K" first="K-H" last="Jöckel">K-H Jöckel</name><affiliation><nlm:affiliation>Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ben Shlomo, Y" sort="Ben Shlomo, Y" uniqKey="Ben Shlomo Y" first="Y" last="Ben-Shlomo">Y. Ben-Shlomo</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sattar, N" sort="Sattar, N" uniqKey="Sattar N" first="N" last="Sattar">N. Sattar</name><affiliation><nlm:affiliation>BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Baumeister, S E" sort="Baumeister, S E" uniqKey="Baumeister S" first="S E" last="Baumeister">S E Baumeister</name><affiliation><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, G Davey" sort="Smith, G Davey" uniqKey="Smith G" first="G Davey" last="Smith">G Davey Smith</name><affiliation><nlm:affiliation>MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Casas, J P" sort="Casas, J P" uniqKey="Casas J" first="J P" last="Casas">J P Casas</name><affiliation><nlm:affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Houston, D K" sort="Houston, D K" uniqKey="Houston D" first="D K" last="Houston">D K Houston</name><affiliation><nlm:affiliation>Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.</nlm:affiliation></affiliation></author><author><name sortKey="M Rz, W" sort="M Rz, W" uniqKey="M Rz W" first="W" last="M Rz">W. M Rz</name><affiliation><nlm:affiliation>Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Christensen, K" sort="Christensen, K" uniqKey="Christensen K" first="K" last="Christensen">K. Christensen</name><affiliation><nlm:affiliation>The Danish Aging Research Center and The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Gudnason, V" sort="Gudnason, V" uniqKey="Gudnason V" first="V" last="Gudnason">V. Gudnason</name><affiliation><nlm:affiliation>Icelandic Heart Association, Kopavogur, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, F B" sort="Hu, F B" uniqKey="Hu F" first="F B" last="Hu">F B Hu</name><affiliation><nlm:affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Metspalu, A" sort="Metspalu, A" uniqKey="Metspalu A" first="A" last="Metspalu">A. Metspalu</name><affiliation><nlm:affiliation>Estonian Genome Center, University of Tartu, Tartu, Estonia.</nlm:affiliation></affiliation></author><author><name sortKey="Ridker, P M" sort="Ridker, P M" uniqKey="Ridker P" first="P M" last="Ridker">P M Ridker</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wareham, N J" sort="Wareham, N J" uniqKey="Wareham N" first="N J" last="Wareham">N J Wareham</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Loos, R J F" sort="Loos, R J F" uniqKey="Loos R" first="R J F" last="Loos">R J F. Loos</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Tiemeier, H" sort="Tiemeier, H" uniqKey="Tiemeier H" first="H" last="Tiemeier">H. Tiemeier</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Sonestedt, E" sort="Sonestedt, E" uniqKey="Sonestedt E" first="E" last="Sonestedt">E. Sonestedt</name><affiliation><nlm:affiliation>Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="S Rensen, T I A" sort="S Rensen, T I A" uniqKey="S Rensen T" first="T I A" last="S Rensen">T I A. S Rensen</name><affiliation><nlm:affiliation>Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25752329</idno><idno type="pmid">25752329</idno><idno type="doi">10.1111/obr.12263</idno><idno type="wicri:Area/PubMed/Corpus">002E81</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002E81</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults.</title><author><name sortKey="Zimmermann, E" sort="Zimmermann, E" uniqKey="Zimmermann E" first="E" last="Zimmermann">E. Zimmermann</name><affiliation><nlm:affiliation>Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey=" Ngquist, L H" sort=" Ngquist, L H" uniqKey=" Ngquist L" first="L H" last=" Ngquist">L H Ngquist</name><affiliation><nlm:affiliation>Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Mirza, S S" sort="Mirza, S S" uniqKey="Mirza S" first="S S" last="Mirza">S S Mirza</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, J H" sort="Zhao, J H" uniqKey="Zhao J" first="J H" last="Zhao">J H Zhao</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Chasman, D I" sort="Chasman, D I" uniqKey="Chasman D" first="D I" last="Chasman">D I Chasman</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Fischer, K" sort="Fischer, K" uniqKey="Fischer K" first="K" last="Fischer">K. Fischer</name><affiliation><nlm:affiliation>Estonian Genome Center, University of Tartu, Tartu, Estonia.</nlm:affiliation></affiliation></author><author><name sortKey="Qi, Q" sort="Qi, Q" uniqKey="Qi Q" first="Q" last="Qi">Q. Qi</name><affiliation><nlm:affiliation>Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, A V" sort="Smith, A V" uniqKey="Smith A" first="A V" last="Smith">A V Smith</name><affiliation><nlm:affiliation>Icelandic Heart Association, Kopavogur, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Thinggaard, M" sort="Thinggaard, M" uniqKey="Thinggaard M" first="M" last="Thinggaard">M. Thinggaard</name><affiliation><nlm:affiliation>The Danish Aging Research Center and The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Jarczok, M N" sort="Jarczok, M N" uniqKey="Jarczok M" first="M N" last="Jarczok">M N Jarczok</name><affiliation><nlm:affiliation>Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Nalls, M A" sort="Nalls, M A" uniqKey="Nalls M" first="M A" last="Nalls">M A Nalls</name><affiliation><nlm:affiliation>Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Trompet, S" sort="Trompet, S" uniqKey="Trompet S" first="S" last="Trompet">S. Trompet</name><affiliation><nlm:affiliation>Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Timpson, N J" sort="Timpson, N J" uniqKey="Timpson N" first="N J" last="Timpson">N J Timpson</name><affiliation><nlm:affiliation>MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Schmidt, B" sort="Schmidt, B" uniqKey="Schmidt B" first="B" last="Schmidt">B. Schmidt</name><affiliation><nlm:affiliation>Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jackson, A U" sort="Jackson, A U" uniqKey="Jackson A" first="A U" last="Jackson">A U Jackson</name><affiliation><nlm:affiliation>Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lyytik Inen, L P" sort="Lyytik Inen, L P" uniqKey="Lyytik Inen L" first="L P" last="Lyytik Inen">L P Lyytik Inen</name><affiliation><nlm:affiliation>Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Verweij, N" sort="Verweij, N" uniqKey="Verweij N" first="N" last="Verweij">N. Verweij</name><affiliation><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Mueller Nurasyid, M" sort="Mueller Nurasyid, M" uniqKey="Mueller Nurasyid M" first="M" last="Mueller-Nurasyid">M. Mueller-Nurasyid</name><affiliation><nlm:affiliation>Department of Medicine I, Ludwig-Maximilians-University, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Vikstrom, M" sort="Vikstrom, M" uniqKey="Vikstrom M" first="M" last="Vikström">M. Vikström</name><affiliation><nlm:affiliation>Karolinska Institutet, Institute of Environmental Medicine, Unit of Cardiovascular Epidemiology, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Marques Vidal, P" sort="Marques Vidal, P" uniqKey="Marques Vidal P" first="P" last="Marques-Vidal">P. Marques-Vidal</name><affiliation><nlm:affiliation>Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Wong, A" sort="Wong, A" uniqKey="Wong A" first="A" last="Wong">A. Wong</name><affiliation><nlm:affiliation>MRC Unit for Lifelong Health and Ageing, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Meidtner, K" sort="Meidtner, K" uniqKey="Meidtner K" first="K" last="Meidtner">K. Meidtner</name><affiliation><nlm:affiliation>Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Middelberg, R P" sort="Middelberg, R P" uniqKey="Middelberg R" first="R P" last="Middelberg">R P Middelberg</name><affiliation><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Strawbridge, R J" sort="Strawbridge, R J" uniqKey="Strawbridge R" first="R J" last="Strawbridge">R J Strawbridge</name><affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Christiansen, L" sort="Christiansen, L" uniqKey="Christiansen L" first="L" last="Christiansen">L. Christiansen</name><affiliation><nlm:affiliation>The Danish Aging Research Center and The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Kyvik, K O" sort="Kyvik, K O" uniqKey="Kyvik K" first="K O" last="Kyvik">K O Kyvik</name><affiliation><nlm:affiliation>Institute of Regional Health Services Research and Odense Patient data Explorative Network, Odense University Hospital, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Hamsten, A" sort="Hamsten, A" uniqKey="Hamsten A" first="A" last="Hamsten">A. Hamsten</name><affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="J Skel Inen, T" sort="J Skel Inen, T" uniqKey="J Skel Inen T" first="T" last="J Skel Inen">T. J Skel Inen</name><affiliation><nlm:affiliation>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Tj Nneland, A" sort="Tj Nneland, A" uniqKey="Tj Nneland A" first="A" last="Tj Nneland">A. Tj Nneland</name><affiliation><nlm:affiliation>Danish Cancer Society Research Centre, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Eriksson, J G" sort="Eriksson, J G" uniqKey="Eriksson J" first="J G" last="Eriksson">J G Eriksson</name><affiliation><nlm:affiliation>Diabetes Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Whitfield, J B" sort="Whitfield, J B" uniqKey="Whitfield J" first="J B" last="Whitfield">J B Whitfield</name><affiliation><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Boeing, H" sort="Boeing, H" uniqKey="Boeing H" first="H" last="Boeing">H. Boeing</name><affiliation><nlm:affiliation>Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hardy, R" sort="Hardy, R" uniqKey="Hardy R" first="R" last="Hardy">R. Hardy</name><affiliation><nlm:affiliation>MRC Unit for Lifelong Health and Ageing, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Vollenweider, P" sort="Vollenweider, P" uniqKey="Vollenweider P" first="P" last="Vollenweider">P. Vollenweider</name><affiliation><nlm:affiliation>Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Leander, K" sort="Leander, K" uniqKey="Leander K" first="K" last="Leander">K. Leander</name><affiliation><nlm:affiliation>Karolinska Institutet, Institute of Environmental Medicine, Unit of Cardiovascular Epidemiology, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Peters, A" sort="Peters, A" uniqKey="Peters A" first="A" last="Peters">A. Peters</name><affiliation><nlm:affiliation>Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK), Partner site Munich Heart Alliance, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Harst, P" sort="Van Der Harst, P" uniqKey="Van Der Harst P" first="P" last="Van Der Harst">P. Van Der Harst</name><affiliation><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Kumari, M" sort="Kumari, M" uniqKey="Kumari M" first="M" last="Kumari">M. Kumari</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lehtim Ki, T" sort="Lehtim Ki, T" uniqKey="Lehtim Ki T" first="T" last="Lehtim Ki">T. Lehtim Ki</name><affiliation><nlm:affiliation>Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Meirhaeghe, A" sort="Meirhaeghe, A" uniqKey="Meirhaeghe A" first="A" last="Meirhaeghe">A. Meirhaeghe</name><affiliation><nlm:affiliation>Inserm, U744, Institut Pasteur de Lille, University Lille Nord de France, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tuomilehto, J" sort="Tuomilehto, J" uniqKey="Tuomilehto J" first="J" last="Tuomilehto">J. Tuomilehto</name><affiliation><nlm:affiliation>Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Jockel, K H" sort="Jockel, K H" uniqKey="Jockel K" first="K-H" last="Jöckel">K-H Jöckel</name><affiliation><nlm:affiliation>Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ben Shlomo, Y" sort="Ben Shlomo, Y" uniqKey="Ben Shlomo Y" first="Y" last="Ben-Shlomo">Y. Ben-Shlomo</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sattar, N" sort="Sattar, N" uniqKey="Sattar N" first="N" last="Sattar">N. Sattar</name><affiliation><nlm:affiliation>BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Baumeister, S E" sort="Baumeister, S E" uniqKey="Baumeister S" first="S E" last="Baumeister">S E Baumeister</name><affiliation><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, G Davey" sort="Smith, G Davey" uniqKey="Smith G" first="G Davey" last="Smith">G Davey Smith</name><affiliation><nlm:affiliation>MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Casas, J P" sort="Casas, J P" uniqKey="Casas J" first="J P" last="Casas">J P Casas</name><affiliation><nlm:affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Houston, D K" sort="Houston, D K" uniqKey="Houston D" first="D K" last="Houston">D K Houston</name><affiliation><nlm:affiliation>Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.</nlm:affiliation></affiliation></author><author><name sortKey="M Rz, W" sort="M Rz, W" uniqKey="M Rz W" first="W" last="M Rz">W. M Rz</name><affiliation><nlm:affiliation>Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Christensen, K" sort="Christensen, K" uniqKey="Christensen K" first="K" last="Christensen">K. Christensen</name><affiliation><nlm:affiliation>The Danish Aging Research Center and The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Gudnason, V" sort="Gudnason, V" uniqKey="Gudnason V" first="V" last="Gudnason">V. Gudnason</name><affiliation><nlm:affiliation>Icelandic Heart Association, Kopavogur, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, F B" sort="Hu, F B" uniqKey="Hu F" first="F B" last="Hu">F B Hu</name><affiliation><nlm:affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Metspalu, A" sort="Metspalu, A" uniqKey="Metspalu A" first="A" last="Metspalu">A. Metspalu</name><affiliation><nlm:affiliation>Estonian Genome Center, University of Tartu, Tartu, Estonia.</nlm:affiliation></affiliation></author><author><name sortKey="Ridker, P M" sort="Ridker, P M" uniqKey="Ridker P" first="P M" last="Ridker">P M Ridker</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wareham, N J" sort="Wareham, N J" uniqKey="Wareham N" first="N J" last="Wareham">N J Wareham</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Loos, R J F" sort="Loos, R J F" uniqKey="Loos R" first="R J F" last="Loos">R J F. Loos</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Tiemeier, H" sort="Tiemeier, H" uniqKey="Tiemeier H" first="H" last="Tiemeier">H. Tiemeier</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Sonestedt, E" sort="Sonestedt, E" uniqKey="Sonestedt E" first="E" last="Sonestedt">E. Sonestedt</name><affiliation><nlm:affiliation>Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="S Rensen, T I A" sort="S Rensen, T I A" uniqKey="S Rensen T" first="T I A" last="S Rensen">T I A. S Rensen</name><affiliation><nlm:affiliation>Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Obesity reviews : an official journal of the International Association for the Study of Obesity</title><idno type="eISSN">1467-789X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adiposity (genetics)</term><term>Alpha-Ketoglutarate-Dependent Dioxygenase FTO</term><term>Body Mass Index</term><term>Genetic Predisposition to Disease</term><term>Genetic Variation</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Obesity (genetics)</term><term>Obesity (mortality)</term><term>Observational Studies as Topic</term><term>Polymorphism, Single Nucleotide</term><term>Proteins (genetics)</term><term>Waist Circumference</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Proteins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Alpha-Ketoglutarate-Dependent Dioxygenase FTO</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adiposity</term><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Obesity</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Body Mass Index</term><term>Genetic Predisposition to Disease</term><term>Genetic Variation</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Observational Studies as Topic</term><term>Polymorphism, Single Nucleotide</term><term>Waist Circumference</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previously, a single nucleotide polymorphism (SNP), rs9939609, in the FTO gene showed a much stronger association with all-cause mortality than expected from its association with body mass index (BMI), body fat mass index (FMI) and waist circumference (WC). This finding implies that the SNP has strong pleiotropic effects on adiposity and adiposity-independent pathological pathways that leads to increased mortality. To investigate this further, we conducted a meta-analysis of similar data from 34 longitudinal studies including 169,551 adult Caucasians among whom 27,100 died during follow-up. Linear regression showed that the minor allele of the FTO SNP was associated with greater BMI (n = 169,551; 0.32 kg m(-2) ; 95% CI 0.28-0.32, P < 1 × 10(-32) ), WC (n = 152,631; 0.76 cm; 0.68-0.84, P < 1 × 10(-32) ) and FMI (n = 48,192; 0.17 kg m(-2) ; 0.13-0.22, P = 1.0 × 10(-13) ). Cox proportional hazard regression analyses for mortality showed that the hazards ratio (HR) for the minor allele of the FTO SNPs was 1.02 (1.00-1.04, P = 0.097), but the apparent excess risk was eliminated after adjustment for BMI and WC (HR: 1.00; 0.98-1.03, P = 0.662) and for FMI (HR: 1.00; 0.96-1.04, P = 0.932). In conclusion, this study does not support that the FTO SNP is associated with all-cause mortality independently of the adiposity phenotypes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25752329</PMID><DateCreated><Year>2015</Year><Month>03</Month><Day>19</Day></DateCreated><DateCompleted><Year>2015</Year><Month>12</Month><Day>28</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1467-789X</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>4</Issue><PubDate><Year>2015</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Obesity reviews : an official journal of the International Association for the Study of Obesity</Title><ISOAbbreviation>Obes Rev</ISOAbbreviation></Journal><ArticleTitle>Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults.</ArticleTitle><Pagination><MedlinePgn>327-340</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/obr.12263</ELocationID><Abstract><AbstractText>Previously, a single nucleotide polymorphism (SNP), rs9939609, in the FTO gene showed a much stronger association with all-cause mortality than expected from its association with body mass index (BMI), body fat mass index (FMI) and waist circumference (WC). This finding implies that the SNP has strong pleiotropic effects on adiposity and adiposity-independent pathological pathways that leads to increased mortality. To investigate this further, we conducted a meta-analysis of similar data from 34 longitudinal studies including 169,551 adult Caucasians among whom 27,100 died during follow-up. Linear regression showed that the minor allele of the FTO SNP was associated with greater BMI (n = 169,551; 0.32 kg m(-2) ; 95% CI 0.28-0.32, P < 1 × 10(-32) ), WC (n = 152,631; 0.76 cm; 0.68-0.84, P < 1 × 10(-32) ) and FMI (n = 48,192; 0.17 kg m(-2) ; 0.13-0.22, P = 1.0 × 10(-13) ). Cox proportional hazard regression analyses for mortality showed that the hazards ratio (HR) for the minor allele of the FTO SNPs was 1.02 (1.00-1.04, P = 0.097), but the apparent excess risk was eliminated after adjustment for BMI and WC (HR: 1.00; 0.98-1.03, P = 0.662) and for FMI (HR: 1.00; 0.96-1.04, P = 0.932). In conclusion, this study does not support that the FTO SNP is associated with all-cause mortality independently of the adiposity phenotypes.</AbstractText><CopyrightInformation>© 2015 World Obesity.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Zimmermann</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Ängquist</LastName><ForeName>L H</ForeName><Initials>LH</Initials><AffiliationInfo><Affiliation>Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mirza</LastName><ForeName>S S</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>J H</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chasman</LastName><ForeName>D I</ForeName><Initials>DI</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fischer</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Estonian Genome Center, University of Tartu, Tartu, Estonia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qi</LastName><ForeName>Q</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>A V</ForeName><Initials>AV</Initials><AffiliationInfo><Affiliation>Icelandic Heart Association, Kopavogur, Iceland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Icelandic, Reykajvik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thinggaard</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>The Danish Aging Research Center and The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jarczok</LastName><ForeName>M N</ForeName><Initials>MN</Initials><AffiliationInfo><Affiliation>Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nalls</LastName><ForeName>M A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trompet</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Timpson</LastName><ForeName>N J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jackson</LastName><ForeName>A U</ForeName><Initials>AU</Initials><AffiliationInfo><Affiliation>Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lyytikäinen</LastName><ForeName>L P</ForeName><Initials>LP</Initials><AffiliationInfo><Affiliation>Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medicine, University of Tampere, Tampere, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verweij</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mueller-Nurasyid</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine I, Ludwig-Maximilians-University, Munich, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK), Partner site Munich Heart Alliance, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vikström</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Karolinska Institutet, Institute of Environmental Medicine, Unit of Cardiovascular Epidemiology, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marques-Vidal</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>MRC Unit for Lifelong Health and Ageing, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meidtner</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Middelberg</LastName><ForeName>R P</ForeName><Initials>RP</Initials><AffiliationInfo><Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Strawbridge</LastName><ForeName>R J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Christiansen</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>The Danish Aging Research Center and The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>FTO-Mortality Collaborating Group</CollectiveName></Author><Author ValidYN="Y"><LastName>Kyvik</LastName><ForeName>K O</ForeName><Initials>KO</Initials><AffiliationInfo><Affiliation>Institute of Regional Health Services Research and Odense Patient data Explorative Network, Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hamsten</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jääskeläinen</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tjønneland</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Danish Cancer Society Research Centre, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eriksson</LastName><ForeName>J G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Diabetes Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of General Practice and Primary Health Care, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Folkhälsan Research Centre, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Whitfield</LastName><ForeName>J B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boeing</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hardy</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>MRC Unit for Lifelong Health and Ageing, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vollenweider</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leander</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Karolinska Institutet, Institute of Environmental Medicine, Unit of Cardiovascular Epidemiology, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK), Partner site Munich Heart Alliance, Munich, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Harst</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Genetic, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Durrer Center for Cardiogenetic Research, ICIN-Neterlands Heart Institute, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumari</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, University College London, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>ISER, University of Essex, Colchester, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lehtimäki</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medicine, University of Tampere, Tampere, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meirhaeghe</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Inserm, U744, Institut Pasteur de Lille, University Lille Nord de France, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tuomilehto</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Vascular Prevention, Danube-University Krems, Krems, Austria.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jöckel</LastName><ForeName>K-H</ForeName><Initials>KH</Initials><AffiliationInfo><Affiliation>Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ben-Shlomo</LastName><ForeName>Y</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sattar</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baumeister</LastName><ForeName>S E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>G Davey</ForeName><Initials>GD</Initials><AffiliationInfo><Affiliation>MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casas</LastName><ForeName>J P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Cardiovascular Science, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Houston</LastName><ForeName>D K</ForeName><Initials>DK</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>März</LastName><ForeName>W</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Synlab Academy, Synlab Services GmbH, Mannheim, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Christensen</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>The Danish Aging Research Center and The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gudnason</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Icelandic Heart Association, Kopavogur, Iceland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Icelandic, Reykajvik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>F B</ForeName><Initials>FB</Initials><AffiliationInfo><Affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Metspalu</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Estonian Genome Center, University of Tartu, Tartu, Estonia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ridker</LastName><ForeName>P M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wareham</LastName><ForeName>N J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loos</LastName><ForeName>R J F</ForeName><Initials>RJF</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tiemeier</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Child and Adolescent Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sonestedt</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sørensen</LastName><ForeName>T I A</ForeName><Initials>TIA</Initials><AffiliationInfo><Affiliation>Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section on Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>DK58845</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AA007535</GrantID><Acronym>AA</Acronym><Agency>NIAAA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>RG/13/2/30098</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 DK058845</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HG004728</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United 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Kingdom</Country></Grant><Grant><GrantID>DK091718</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01 AG062106</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MC_UU_12015/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 DK062370</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG032098</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA055075</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MC_U106179471</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R37 AG013196</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United 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Kingdom</Country></Grant><Grant><GrantID>MC_UU_12013/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 LM010098</GrantID><Acronym>LM</Acronym><Agency>NLM NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K24 DK080140</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL034594</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EY015473</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HL34594</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>DK08014</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA182913</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA49449</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 DK062370</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AA010249</GrantID><Acronym>AA</Acronym><Agency>NIAAA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL071981</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA047988</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01HG004728</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL080467</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MR/K013351/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 AG013196</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HL073168</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>EY015473</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL088521</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA049449</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL073168</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA049449</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01HG004399</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HG004399</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>03</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Obes Rev</MedlineTA><NlmUniqueID>100897395</NlmUniqueID><ISSNLinking>1467-7881</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011506">Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.11.33</RegistryNumber><NameOfSubstance UI="D000071516">Alpha-Ketoglutarate-Dependent Dioxygenase FTO</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.11.33</RegistryNumber><NameOfSubstance UI="C526492">FTO protein, human</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2013;8(8):e71901</RefSource><PMID Version="1">23977173</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Epidemiol. 2013 Nov;28(11):889-926</RefSource><PMID Version="1">24258680</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mayo Clin Proc. 2014 Mar;89(3):335-45</RefSource><PMID Version="1">24582192</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Epidemiol. 2015 Aug;44(4):1137-47</RefSource><PMID 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