DNAM-1 expression marks an alternative program of NK cell maturation.
Identifieur interne : 002E76 ( PubMed/Corpus ); précédent : 002E75; suivant : 002E77DNAM-1 expression marks an alternative program of NK cell maturation.
Auteurs : Ludovic Martinet ; Lucas Ferrari De Andrade ; Camille Guillerey ; Jason S. Lee ; Jing Liu ; Fernando Souza-Fonseca-Guimaraes ; Dana S. Hutchinson ; Tatiana B. Kolesnik ; Sandra E. Nicholson ; Nicholas D. Huntington ; Mark J. SmythSource :
- Cell reports [ 2211-1247 ] ; 2015.
English descriptors
- KwdEn :
- Adaptor Proteins, Signal Transducing (biosynthesis), Adaptor Proteins, Signal Transducing (metabolism), Antigens, Differentiation, T-Lymphocyte (biosynthesis), Antigens, Differentiation, T-Lymphocyte (genetics), Antigens, Differentiation, T-Lymphocyte (immunology), Cell Lineage (genetics), Cell Lineage (immunology), Cytokines (immunology), Cytokines (metabolism), Gene Expression Regulation, Humans, Interleukin-15 (immunology), Interleukin-15 (metabolism), Killer Cells, Natural (cytology), Killer Cells, Natural (metabolism), Signal Transduction.
- MESH :
- chemical , biosynthesis : Adaptor Proteins, Signal Transducing, Antigens, Differentiation, T-Lymphocyte.
- chemical , genetics : Antigens, Differentiation, T-Lymphocyte.
- chemical , immunology : Antigens, Differentiation, T-Lymphocyte, Cytokines, Interleukin-15.
- chemical , metabolism : Adaptor Proteins, Signal Transducing, Cytokines, Interleukin-15.
- cytology : Killer Cells, Natural.
- genetics : Cell Lineage.
- immunology : Cell Lineage.
- metabolism : Killer Cells, Natural.
- Gene Expression Regulation, Humans, Signal Transduction.
Abstract
Natural killer (NK) cells comprise a heterogeneous population of cells important for pathogen defense and cancer surveillance. However, the functional significance of this diversity is not fully understood. Here, we demonstrate through transcriptional profiling and functional studies that the activating receptor DNAM-1 (CD226) identifies two distinct NK cell functional subsets: DNAM-1(+) and DNAM-1(-) NK cells. DNAM-1(+) NK cells produce high levels of inflammatory cytokines, have enhanced interleukin 15 signaling, and proliferate vigorously. By contrast, DNAM-1(-) NK cells that differentiate from DNAM-1(+) NK cells have greater expression of NK-cell-receptor-related genes and are higher producers of MIP1 chemokines. Collectively, our data reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.
DOI: 10.1016/j.celrep.2015.03.006
PubMed: 25818301
Links to Exploration step
pubmed:25818301Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">DNAM-1 expression marks an alternative program of NK cell maturation.</title><author><name sortKey="Martinet, Ludovic" sort="Martinet, Ludovic" uniqKey="Martinet L" first="Ludovic" last="Martinet">Ludovic Martinet</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse 31000, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ferrari De Andrade, Lucas" sort="Ferrari De Andrade, Lucas" uniqKey="Ferrari De Andrade L" first="Lucas" last="Ferrari De Andrade">Lucas Ferrari De Andrade</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; Células Inflamatórias e Neoplásicas group, Universidade Federal do Paraná, Curitiba, Paraná 81530-001, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Guillerey, Camille" sort="Guillerey, Camille" uniqKey="Guillerey C" first="Camille" last="Guillerey">Camille Guillerey</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Jason S" sort="Lee, Jason S" uniqKey="Lee J" first="Jason S" last="Lee">Jason S. Lee</name><affiliation><nlm:affiliation>Control of Gene Expression Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Jing" sort="Liu, Jing" uniqKey="Liu J" first="Jing" last="Liu">Jing Liu</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Souza Fonseca Guimaraes, Fernando" sort="Souza Fonseca Guimaraes, Fernando" uniqKey="Souza Fonseca Guimaraes F" first="Fernando" last="Souza-Fonseca-Guimaraes">Fernando Souza-Fonseca-Guimaraes</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Hutchinson, Dana S" sort="Hutchinson, Dana S" uniqKey="Hutchinson D" first="Dana S" last="Hutchinson">Dana S. Hutchinson</name><affiliation><nlm:affiliation>Department of Pharmacology, Drug Discovery Biology, Monash Institute of Pharmaceutical, Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Kolesnik, Tatiana B" sort="Kolesnik, Tatiana B" uniqKey="Kolesnik T" first="Tatiana B" last="Kolesnik">Tatiana B. Kolesnik</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Nicholson, Sandra E" sort="Nicholson, Sandra E" uniqKey="Nicholson S" first="Sandra E" last="Nicholson">Sandra E. Nicholson</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Huntington, Nicholas D" sort="Huntington, Nicholas D" uniqKey="Huntington N" first="Nicholas D" last="Huntington">Nicholas D. Huntington</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J" last="Smyth">Mark J. Smyth</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; School of Medicine, University of Queensland, Herston, QLD 4006, Australia. Electronic address: mark.smyth@qimrberghofer.edu.au.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25818301</idno><idno type="pmid">25818301</idno><idno type="doi">10.1016/j.celrep.2015.03.006</idno><idno type="wicri:Area/PubMed/Corpus">002E76</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002E76</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">DNAM-1 expression marks an alternative program of NK cell maturation.</title><author><name sortKey="Martinet, Ludovic" sort="Martinet, Ludovic" uniqKey="Martinet L" first="Ludovic" last="Martinet">Ludovic Martinet</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse 31000, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ferrari De Andrade, Lucas" sort="Ferrari De Andrade, Lucas" uniqKey="Ferrari De Andrade L" first="Lucas" last="Ferrari De Andrade">Lucas Ferrari De Andrade</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; Células Inflamatórias e Neoplásicas group, Universidade Federal do Paraná, Curitiba, Paraná 81530-001, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Guillerey, Camille" sort="Guillerey, Camille" uniqKey="Guillerey C" first="Camille" last="Guillerey">Camille Guillerey</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Jason S" sort="Lee, Jason S" uniqKey="Lee J" first="Jason S" last="Lee">Jason S. Lee</name><affiliation><nlm:affiliation>Control of Gene Expression Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Jing" sort="Liu, Jing" uniqKey="Liu J" first="Jing" last="Liu">Jing Liu</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Souza Fonseca Guimaraes, Fernando" sort="Souza Fonseca Guimaraes, Fernando" uniqKey="Souza Fonseca Guimaraes F" first="Fernando" last="Souza-Fonseca-Guimaraes">Fernando Souza-Fonseca-Guimaraes</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Hutchinson, Dana S" sort="Hutchinson, Dana S" uniqKey="Hutchinson D" first="Dana S" last="Hutchinson">Dana S. Hutchinson</name><affiliation><nlm:affiliation>Department of Pharmacology, Drug Discovery Biology, Monash Institute of Pharmaceutical, Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Kolesnik, Tatiana B" sort="Kolesnik, Tatiana B" uniqKey="Kolesnik T" first="Tatiana B" last="Kolesnik">Tatiana B. Kolesnik</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Nicholson, Sandra E" sort="Nicholson, Sandra E" uniqKey="Nicholson S" first="Sandra E" last="Nicholson">Sandra E. Nicholson</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Huntington, Nicholas D" sort="Huntington, Nicholas D" uniqKey="Huntington N" first="Nicholas D" last="Huntington">Nicholas D. Huntington</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J" last="Smyth">Mark J. Smyth</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; School of Medicine, University of Queensland, Herston, QLD 4006, Australia. Electronic address: mark.smyth@qimrberghofer.edu.au.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cell reports</title><idno type="eISSN">2211-1247</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptor Proteins, Signal Transducing (biosynthesis)</term><term>Adaptor Proteins, Signal Transducing (metabolism)</term><term>Antigens, Differentiation, T-Lymphocyte (biosynthesis)</term><term>Antigens, Differentiation, T-Lymphocyte (genetics)</term><term>Antigens, Differentiation, T-Lymphocyte (immunology)</term><term>Cell Lineage (genetics)</term><term>Cell Lineage (immunology)</term><term>Cytokines (immunology)</term><term>Cytokines (metabolism)</term><term>Gene Expression Regulation</term><term>Humans</term><term>Interleukin-15 (immunology)</term><term>Interleukin-15 (metabolism)</term><term>Killer Cells, Natural (cytology)</term><term>Killer Cells, Natural (metabolism)</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term><term>Antigens, Differentiation, T-Lymphocyte</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Differentiation, T-Lymphocyte</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Differentiation, T-Lymphocyte</term><term>Cytokines</term><term>Interleukin-15</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term><term>Cytokines</term><term>Interleukin-15</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Killer Cells, Natural</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cell Lineage</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cell Lineage</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Killer Cells, Natural</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Gene Expression Regulation</term><term>Humans</term><term>Signal Transduction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Natural killer (NK) cells comprise a heterogeneous population of cells important for pathogen defense and cancer surveillance. However, the functional significance of this diversity is not fully understood. Here, we demonstrate through transcriptional profiling and functional studies that the activating receptor DNAM-1 (CD226) identifies two distinct NK cell functional subsets: DNAM-1(+) and DNAM-1(-) NK cells. DNAM-1(+) NK cells produce high levels of inflammatory cytokines, have enhanced interleukin 15 signaling, and proliferate vigorously. By contrast, DNAM-1(-) NK cells that differentiate from DNAM-1(+) NK cells have greater expression of NK-cell-receptor-related genes and are higher producers of MIP1 chemokines. Collectively, our data reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25818301</PMID><DateCreated><Year>2015</Year><Month>04</Month><Day>12</Day></DateCreated><DateCompleted><Year>2016</Year><Month>01</Month><Day>04</Day></DateCompleted><DateRevised><Year>2015</Year><Month>04</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2211-1247</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>1</Issue><PubDate><Year>2015</Year><Month>Apr</Month><Day>07</Day></PubDate></JournalIssue><Title>Cell reports</Title><ISOAbbreviation>Cell Rep</ISOAbbreviation></Journal><ArticleTitle>DNAM-1 expression marks an alternative program of NK cell maturation.</ArticleTitle><Pagination><MedlinePgn>85-97</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.celrep.2015.03.006</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S2211-1247(15)00259-4</ELocationID><Abstract><AbstractText>Natural killer (NK) cells comprise a heterogeneous population of cells important for pathogen defense and cancer surveillance. However, the functional significance of this diversity is not fully understood. Here, we demonstrate through transcriptional profiling and functional studies that the activating receptor DNAM-1 (CD226) identifies two distinct NK cell functional subsets: DNAM-1(+) and DNAM-1(-) NK cells. DNAM-1(+) NK cells produce high levels of inflammatory cytokines, have enhanced interleukin 15 signaling, and proliferate vigorously. By contrast, DNAM-1(-) NK cells that differentiate from DNAM-1(+) NK cells have greater expression of NK-cell-receptor-related genes and are higher producers of MIP1 chemokines. Collectively, our data reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.</AbstractText><CopyrightInformation>Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Martinet</LastName><ForeName>Ludovic</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse 31000, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferrari De Andrade</LastName><ForeName>Lucas</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; Células Inflamatórias e Neoplásicas group, Universidade Federal do Paraná, Curitiba, Paraná 81530-001, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guillerey</LastName><ForeName>Camille</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Jason S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Control of Gene Expression Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Souza-Fonseca-Guimaraes</LastName><ForeName>Fernando</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hutchinson</LastName><ForeName>Dana S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, Drug Discovery Biology, Monash Institute of Pharmaceutical, Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kolesnik</LastName><ForeName>Tatiana B</ForeName><Initials>TB</Initials><AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nicholson</LastName><ForeName>Sandra E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huntington</LastName><ForeName>Nicholas D</ForeName><Initials>ND</Initials><AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smyth</LastName><ForeName>Mark J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; School of Medicine, University of Queensland, Herston, QLD 4006, Australia. Electronic address: mark.smyth@qimrberghofer.edu.au.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>GEO</DataBankName><AccessionNumberList><AccessionNumber>GSE66281</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>03</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cell Rep</MedlineTA><NlmUniqueID>101573691</NlmUniqueID></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D048868">Adaptor Proteins, Signal Transducing</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000945">Antigens, Differentiation, T-Lymphocyte</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C108133">CD226 antigen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019409">Interleukin-15</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C493277">MAPKAP1 protein, human</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D048868" MajorTopicYN="N">Adaptor Proteins, Signal Transducing</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000945" MajorTopicYN="N">Antigens, Differentiation, T-Lymphocyte</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019070" MajorTopicYN="N">Cell Lineage</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019409" MajorTopicYN="N">Interleukin-15</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007694" MajorTopicYN="N">Killer Cells, Natural</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>10</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>12</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>02</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>3</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>3</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>1</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25818301</ArticleId><ArticleId IdType="pii">S2211-1247(15)00259-4</ArticleId><ArticleId IdType="doi">10.1016/j.celrep.2015.03.006</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002E76 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 002E76 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:25818301
|texte= DNAM-1 expression marks an alternative program of NK cell maturation.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:25818301" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |