Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.
Identifieur interne : 002C67 ( PubMed/Corpus ); précédent : 002C66; suivant : 002C68Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.
Auteurs : Rachel S. Van Der Post ; Ingrid P. Vogelaar ; Fátima Carneiro ; Parry Guilford ; David Huntsman ; Nicoline Hoogerbrugge ; Carlos Caldas ; Karen E Chelcun Schreiber ; Richard H. Hardwick ; Margreet G E M. Ausems ; Linda Bardram ; Patrick R. Benusiglio ; Tanya M. Bisseling ; Vanessa Blair ; Eveline Bleiker ; Alex Boussioutas ; Annemieke Cats ; Daniel Coit ; Lynn Degregorio ; Joana Figueiredo ; James M. Ford ; Esther Heijkoop ; Rosella Hermens ; Bostjan Humar ; Pardeep Kaurah ; Gisella Keller ; Jennifer Lai ; Marjolijn J L. Ligtenberg ; Maria O'Donovan ; Carla Oliveira ; Hugo Pinheiro ; Krish Ragunath ; Esther Rasenberg ; Susan Richardson ; Franco Roviello ; Hans Schackert ; Raquel Seruca ; Amy Taylor ; Anouk Ter Huurne ; Marc Tischkowitz ; Sheena Tjon A. Joe ; Benjamin Van Dijck ; Nicole C T. Van Grieken ; Richard Van Hillegersberg ; Johanna W. Van Sandick ; Rianne Vehof ; J Han Van Krieken ; Rebecca C. FitzgeraldSource :
- Journal of medical genetics [ 1468-6244 ] ; 2015.
English descriptors
- KwdEn :
- Breast Neoplasms (diagnosis), Breast Neoplasms (epidemiology), Breast Neoplasms (genetics), Cadherins (genetics), Colorectal Neoplasms (diagnosis), Colorectal Neoplasms (epidemiology), Colorectal Neoplasms (genetics), DNA Mutational Analysis, Early Detection of Cancer (methods), Female, Genetic Counseling, Genetic Testing (methods), Germ-Line Mutation, Heterozygote, Humans, Population Surveillance, Practice Guidelines as Topic, Pregnancy, Stomach Neoplasms (diagnosis), Stomach Neoplasms (epidemiology), Stomach Neoplasms (genetics).
- MESH :
- chemical , genetics : Cadherins.
- diagnosis : Breast Neoplasms, Colorectal Neoplasms, Stomach Neoplasms.
- epidemiology : Breast Neoplasms, Colorectal Neoplasms, Stomach Neoplasms.
- genetics : Breast Neoplasms, Colorectal Neoplasms, Stomach Neoplasms.
- methods : Early Detection of Cancer, Genetic Testing.
- DNA Mutational Analysis, Female, Genetic Counseling, Germ-Line Mutation, Heterozygote, Humans, Population Surveillance, Practice Guidelines as Topic, Pregnancy.
Abstract
Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic testing, surgery, surveillance strategies, pathology reporting and the patient's perspective on multiple aspects, including diet post gastrectomy. The updated guidelines include revised CDH1 testing criteria (taking into account first-degree and second-degree relatives): (1) families with two or more patients with gastric cancer at any age, one confirmed DGC; (2) individuals with DGC before the age of 40 and (3) families with diagnoses of both DGC and LBC (one diagnosis before the age of 50). Additionally, CDH1 testing could be considered in patients with bilateral or familial LBC before the age of 50, patients with DGC and cleft lip/palate, and those with precursor lesions for signet ring cell carcinoma. Given the high mortality associated with invasive disease, prophylactic total gastrectomy at a centre of expertise is advised for individuals with pathogenic CDH1 mutations. Breast cancer surveillance with annual breast MRI starting at age 30 for women with a CDH1 mutation is recommended. Standardised endoscopic surveillance in experienced centres is recommended for those opting not to have gastrectomy at the current time, those with CDH1 variants of uncertain significance and those that fulfil hereditary DGC criteria without germline CDH1 mutations. Expert histopathological confirmation of (early) signet ring cell carcinoma is recommended. The impact of gastrectomy and mastectomy should not be underestimated; these can have severe consequences on a psychological, physiological and metabolic level. Nutritional problems should be carefully monitored.
DOI: 10.1136/jmedgenet-2015-103094
PubMed: 25979631
Links to Exploration step
pubmed:25979631Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.</title><author><name sortKey="Van Der Post, Rachel S" sort="Van Der Post, Rachel S" uniqKey="Van Der Post R" first="Rachel S" last="Van Der Post">Rachel S. Van Der Post</name><affiliation><nlm:affiliation>Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Vogelaar, Ingrid P" sort="Vogelaar, Ingrid P" uniqKey="Vogelaar I" first="Ingrid P" last="Vogelaar">Ingrid P. Vogelaar</name><affiliation><nlm:affiliation>Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Carneiro, Fatima" sort="Carneiro, Fatima" uniqKey="Carneiro F" first="Fátima" last="Carneiro">Fátima Carneiro</name><affiliation><nlm:affiliation>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal Department of Pathology and Oncology, Medical Faculty of the University of Porto, Porto, Portugal Centro Hospitalar São João, Porto, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Guilford, Parry" sort="Guilford, Parry" uniqKey="Guilford P" first="Parry" last="Guilford">Parry Guilford</name><affiliation><nlm:affiliation>Department of Biochemistry, University of Otago, Dunedin, New Zealand.</nlm:affiliation></affiliation></author><author><name sortKey="Huntsman, David" sort="Huntsman, David" uniqKey="Huntsman D" first="David" last="Huntsman">David Huntsman</name><affiliation><nlm:affiliation>British Columbia Cancer Agency, Vancouver, British Columbia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hoogerbrugge, Nicoline" sort="Hoogerbrugge, Nicoline" uniqKey="Hoogerbrugge N" first="Nicoline" last="Hoogerbrugge">Nicoline Hoogerbrugge</name><affiliation><nlm:affiliation>Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Caldas, Carlos" sort="Caldas, Carlos" uniqKey="Caldas C" first="Carlos" last="Caldas">Carlos Caldas</name><affiliation><nlm:affiliation>Department of Oncology, University of Cambridge, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Schreiber, Karen E Chelcun" sort="Schreiber, Karen E Chelcun" uniqKey="Schreiber K" first="Karen E Chelcun" last="Schreiber">Karen E Chelcun Schreiber</name><affiliation><nlm:affiliation>No Stomach For Cancer, Inc., Madison, Wisconsin, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hardwick, Richard H" sort="Hardwick, Richard H" uniqKey="Hardwick R" first="Richard H" last="Hardwick">Richard H. Hardwick</name><affiliation><nlm:affiliation>Department of Oesophago-Gastric Surgery, Addenbrooke's Hospital, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ausems, Margreet G E M" sort="Ausems, Margreet G E M" uniqKey="Ausems M" first="Margreet G E M" last="Ausems">Margreet G E M. Ausems</name><affiliation><nlm:affiliation>Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Bardram, Linda" sort="Bardram, Linda" uniqKey="Bardram L" first="Linda" last="Bardram">Linda Bardram</name><affiliation><nlm:affiliation>Department of Surgical Gastroenterology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Benusiglio, Patrick R" sort="Benusiglio, Patrick R" uniqKey="Benusiglio P" first="Patrick R" last="Benusiglio">Patrick R. Benusiglio</name><affiliation><nlm:affiliation>Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bisseling, Tanya M" sort="Bisseling, Tanya M" uniqKey="Bisseling T" first="Tanya M" last="Bisseling">Tanya M. Bisseling</name><affiliation><nlm:affiliation>Department of Gastroenterology, Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Blair, Vanessa" sort="Blair, Vanessa" uniqKey="Blair V" first="Vanessa" last="Blair">Vanessa Blair</name><affiliation><nlm:affiliation>Vinery Lane Surgery, Whangarei, New Zealand.</nlm:affiliation></affiliation></author><author><name sortKey="Bleiker, Eveline" sort="Bleiker, Eveline" uniqKey="Bleiker E" first="Eveline" last="Bleiker">Eveline Bleiker</name><affiliation><nlm:affiliation>Division of Psychosocial Research and Epidemiology/Family Cancer Clinic, The Netherlands Cancer Institute, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Boussioutas, Alex" sort="Boussioutas, Alex" uniqKey="Boussioutas A" first="Alex" last="Boussioutas">Alex Boussioutas</name><affiliation><nlm:affiliation>Sir Peter MacCallum Department of Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cats, Annemieke" sort="Cats, Annemieke" uniqKey="Cats A" first="Annemieke" last="Cats">Annemieke Cats</name><affiliation><nlm:affiliation>Department of Gastroenterology and Hepatology, Netherlands Cancer Institute/ Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Coit, Daniel" sort="Coit, Daniel" uniqKey="Coit D" first="Daniel" last="Coit">Daniel Coit</name><affiliation><nlm:affiliation>Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Degregorio, Lynn" sort="Degregorio, Lynn" uniqKey="Degregorio L" first="Lynn" last="Degregorio">Lynn Degregorio</name><affiliation><nlm:affiliation>The DeGregorio Family Foundation for Stomach and Esophageal Cancer Research, Pleasantville, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Figueiredo, Joana" sort="Figueiredo, Joana" uniqKey="Figueiredo J" first="Joana" last="Figueiredo">Joana Figueiredo</name><affiliation><nlm:affiliation>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Ford, James M" sort="Ford, James M" uniqKey="Ford J" first="James M" last="Ford">James M. Ford</name><affiliation><nlm:affiliation>Division of Oncology, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Heijkoop, Esther" sort="Heijkoop, Esther" uniqKey="Heijkoop E" first="Esther" last="Heijkoop">Esther Heijkoop</name><affiliation><nlm:affiliation>Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hermens, Rosella" sort="Hermens, Rosella" uniqKey="Hermens R" first="Rosella" last="Hermens">Rosella Hermens</name><affiliation><nlm:affiliation>Scientific Institute for Quality of Healthcare, Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Humar, Bostjan" sort="Humar, Bostjan" uniqKey="Humar B" first="Bostjan" last="Humar">Bostjan Humar</name><affiliation><nlm:affiliation>Division of Surgical Research, University of Zurich, Zurich, Suisse.</nlm:affiliation></affiliation></author><author><name sortKey="Kaurah, Pardeep" sort="Kaurah, Pardeep" uniqKey="Kaurah P" first="Pardeep" last="Kaurah">Pardeep Kaurah</name><affiliation><nlm:affiliation>Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Keller, Gisella" sort="Keller, Gisella" uniqKey="Keller G" first="Gisella" last="Keller">Gisella Keller</name><affiliation><nlm:affiliation>Institute of Pathology, Technische Universität, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lai, Jennifer" sort="Lai, Jennifer" uniqKey="Lai J" first="Jennifer" last="Lai">Jennifer Lai</name><affiliation><nlm:affiliation>No Stomach For Cancer, Inc., Madison, Wisconsin, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ligtenberg, Marjolijn J L" sort="Ligtenberg, Marjolijn J L" uniqKey="Ligtenberg M" first="Marjolijn J L" last="Ligtenberg">Marjolijn J L. Ligtenberg</name><affiliation><nlm:affiliation>Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="O Donovan, Maria" sort="O Donovan, Maria" uniqKey="O Donovan M" first="Maria" last="O'Donovan">Maria O'Donovan</name><affiliation><nlm:affiliation>Department of Histopathology, Cambridge University Hospitals NHS Trust, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Oliveira, Carla" sort="Oliveira, Carla" uniqKey="Oliveira C" first="Carla" last="Oliveira">Carla Oliveira</name><affiliation><nlm:affiliation>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal Department of Pathology and Oncology, Medical Faculty of the University of Porto, Porto, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Pinheiro, Hugo" sort="Pinheiro, Hugo" uniqKey="Pinheiro H" first="Hugo" last="Pinheiro">Hugo Pinheiro</name><affiliation><nlm:affiliation>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Ragunath, Krish" sort="Ragunath, Krish" uniqKey="Ragunath K" first="Krish" last="Ragunath">Krish Ragunath</name><affiliation><nlm:affiliation>NIHR Biomedical Research Unit, Nottingham Digestive Diseases Centre, Queens Medical Centre campus, Nottingham University Hospitals NHS Trust, Nottingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Rasenberg, Esther" sort="Rasenberg, Esther" uniqKey="Rasenberg E" first="Esther" last="Rasenberg">Esther Rasenberg</name><affiliation><nlm:affiliation>Patient representative, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Richardson, Susan" sort="Richardson, Susan" uniqKey="Richardson S" first="Susan" last="Richardson">Susan Richardson</name><affiliation><nlm:affiliation>Department of Oncology, Familial Gastric Cancer Registry, Cambridge University Hospital, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Roviello, Franco" sort="Roviello, Franco" uniqKey="Roviello F" first="Franco" last="Roviello">Franco Roviello</name><affiliation><nlm:affiliation>Department of General Surgery and Surgical Oncology, University of Siena, Siena, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Schackert, Hans" sort="Schackert, Hans" uniqKey="Schackert H" first="Hans" last="Schackert">Hans Schackert</name><affiliation><nlm:affiliation>Department of Surgical Research, Technical University Dresden, Dresden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Seruca, Raquel" sort="Seruca, Raquel" uniqKey="Seruca R" first="Raquel" last="Seruca">Raquel Seruca</name><affiliation><nlm:affiliation>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal Department of Pathology and Oncology, Medical Faculty of the University of Porto, Porto, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Taylor, Amy" sort="Taylor, Amy" uniqKey="Taylor A" first="Amy" last="Taylor">Amy Taylor</name><affiliation><nlm:affiliation>Cambridge University Hospital, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ter Huurne, Anouk" sort="Ter Huurne, Anouk" uniqKey="Ter Huurne A" first="Anouk" last="Ter Huurne">Anouk Ter Huurne</name><affiliation><nlm:affiliation>Stichting CDH1, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Tischkowitz, Marc" sort="Tischkowitz, Marc" uniqKey="Tischkowitz M" first="Marc" last="Tischkowitz">Marc Tischkowitz</name><affiliation><nlm:affiliation>Department of Medical Genetics, University of Cambridge, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Joe, Sheena Tjon A" sort="Joe, Sheena Tjon A" uniqKey="Joe S" first="Sheena Tjon A" last="Joe">Sheena Tjon A. Joe</name><affiliation><nlm:affiliation>Division of Oncology, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Van Dijck, Benjamin" sort="Van Dijck, Benjamin" uniqKey="Van Dijck B" first="Benjamin" last="Van Dijck">Benjamin Van Dijck</name><affiliation><nlm:affiliation>Stichting CDH1, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van Grieken, Nicole C T" sort="Van Grieken, Nicole C T" uniqKey="Van Grieken N" first="Nicole C T" last="Van Grieken">Nicole C T. Van Grieken</name><affiliation><nlm:affiliation>Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van Hillegersberg, Richard" sort="Van Hillegersberg, Richard" uniqKey="Van Hillegersberg R" first="Richard" last="Van Hillegersberg">Richard Van Hillegersberg</name><affiliation><nlm:affiliation>Department of Surgical Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van Sandick, Johanna W" sort="Van Sandick, Johanna W" uniqKey="Van Sandick J" first="Johanna W" last="Van Sandick">Johanna W. Van Sandick</name><affiliation><nlm:affiliation>Department of Surgery, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Vehof, Rianne" sort="Vehof, Rianne" uniqKey="Vehof R" first="Rianne" last="Vehof">Rianne Vehof</name><affiliation><nlm:affiliation>Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van Krieken, J Han" sort="Van Krieken, J Han" uniqKey="Van Krieken J" first="J Han" last="Van Krieken">J Han Van Krieken</name><affiliation><nlm:affiliation>Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Fitzgerald, Rebecca C" sort="Fitzgerald, Rebecca C" uniqKey="Fitzgerald R" first="Rebecca C" last="Fitzgerald">Rebecca C. Fitzgerald</name><affiliation><nlm:affiliation>Cambridge NIHR Biomedical Research Centre, University of Cambridge NHS Foundation Trust MRC Cancer Unit, Hutchison/MRC Research Centre, Cambridge, UK Department Gastroenterology, Cambridge University Hospitals, UK.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25979631</idno><idno type="pmid">25979631</idno><idno type="doi">10.1136/jmedgenet-2015-103094</idno><idno type="wicri:Area/PubMed/Corpus">002C67</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002C67</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.</title><author><name sortKey="Van Der Post, Rachel S" sort="Van Der Post, Rachel S" uniqKey="Van Der Post R" first="Rachel S" last="Van Der Post">Rachel S. Van Der Post</name><affiliation><nlm:affiliation>Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Vogelaar, Ingrid P" sort="Vogelaar, Ingrid P" uniqKey="Vogelaar I" first="Ingrid P" last="Vogelaar">Ingrid P. Vogelaar</name><affiliation><nlm:affiliation>Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Carneiro, Fatima" sort="Carneiro, Fatima" uniqKey="Carneiro F" first="Fátima" last="Carneiro">Fátima Carneiro</name><affiliation><nlm:affiliation>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal Department of Pathology and Oncology, Medical Faculty of the University of Porto, Porto, Portugal Centro Hospitalar São João, Porto, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Guilford, Parry" sort="Guilford, Parry" uniqKey="Guilford P" first="Parry" last="Guilford">Parry Guilford</name><affiliation><nlm:affiliation>Department of Biochemistry, University of Otago, Dunedin, New Zealand.</nlm:affiliation></affiliation></author><author><name sortKey="Huntsman, David" sort="Huntsman, David" uniqKey="Huntsman D" first="David" last="Huntsman">David Huntsman</name><affiliation><nlm:affiliation>British Columbia Cancer Agency, Vancouver, British Columbia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hoogerbrugge, Nicoline" sort="Hoogerbrugge, Nicoline" uniqKey="Hoogerbrugge N" first="Nicoline" last="Hoogerbrugge">Nicoline Hoogerbrugge</name><affiliation><nlm:affiliation>Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Caldas, Carlos" sort="Caldas, Carlos" uniqKey="Caldas C" first="Carlos" last="Caldas">Carlos Caldas</name><affiliation><nlm:affiliation>Department of Oncology, University of Cambridge, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Schreiber, Karen E Chelcun" sort="Schreiber, Karen E Chelcun" uniqKey="Schreiber K" first="Karen E Chelcun" last="Schreiber">Karen E Chelcun Schreiber</name><affiliation><nlm:affiliation>No Stomach For Cancer, Inc., Madison, Wisconsin, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hardwick, Richard H" sort="Hardwick, Richard H" uniqKey="Hardwick R" first="Richard H" last="Hardwick">Richard H. Hardwick</name><affiliation><nlm:affiliation>Department of Oesophago-Gastric Surgery, Addenbrooke's Hospital, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ausems, Margreet G E M" sort="Ausems, Margreet G E M" uniqKey="Ausems M" first="Margreet G E M" last="Ausems">Margreet G E M. Ausems</name><affiliation><nlm:affiliation>Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Bardram, Linda" sort="Bardram, Linda" uniqKey="Bardram L" first="Linda" last="Bardram">Linda Bardram</name><affiliation><nlm:affiliation>Department of Surgical Gastroenterology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Benusiglio, Patrick R" sort="Benusiglio, Patrick R" uniqKey="Benusiglio P" first="Patrick R" last="Benusiglio">Patrick R. Benusiglio</name><affiliation><nlm:affiliation>Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bisseling, Tanya M" sort="Bisseling, Tanya M" uniqKey="Bisseling T" first="Tanya M" last="Bisseling">Tanya M. Bisseling</name><affiliation><nlm:affiliation>Department of Gastroenterology, Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Blair, Vanessa" sort="Blair, Vanessa" uniqKey="Blair V" first="Vanessa" last="Blair">Vanessa Blair</name><affiliation><nlm:affiliation>Vinery Lane Surgery, Whangarei, New Zealand.</nlm:affiliation></affiliation></author><author><name sortKey="Bleiker, Eveline" sort="Bleiker, Eveline" uniqKey="Bleiker E" first="Eveline" last="Bleiker">Eveline Bleiker</name><affiliation><nlm:affiliation>Division of Psychosocial Research and Epidemiology/Family Cancer Clinic, The Netherlands Cancer Institute, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Boussioutas, Alex" sort="Boussioutas, Alex" uniqKey="Boussioutas A" first="Alex" last="Boussioutas">Alex Boussioutas</name><affiliation><nlm:affiliation>Sir Peter MacCallum Department of Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cats, Annemieke" sort="Cats, Annemieke" uniqKey="Cats A" first="Annemieke" last="Cats">Annemieke Cats</name><affiliation><nlm:affiliation>Department of Gastroenterology and Hepatology, Netherlands Cancer Institute/ Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Coit, Daniel" sort="Coit, Daniel" uniqKey="Coit D" first="Daniel" last="Coit">Daniel Coit</name><affiliation><nlm:affiliation>Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Degregorio, Lynn" sort="Degregorio, Lynn" uniqKey="Degregorio L" first="Lynn" last="Degregorio">Lynn Degregorio</name><affiliation><nlm:affiliation>The DeGregorio Family Foundation for Stomach and Esophageal Cancer Research, Pleasantville, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Figueiredo, Joana" sort="Figueiredo, Joana" uniqKey="Figueiredo J" first="Joana" last="Figueiredo">Joana Figueiredo</name><affiliation><nlm:affiliation>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Ford, James M" sort="Ford, James M" uniqKey="Ford J" first="James M" last="Ford">James M. Ford</name><affiliation><nlm:affiliation>Division of Oncology, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Heijkoop, Esther" sort="Heijkoop, Esther" uniqKey="Heijkoop E" first="Esther" last="Heijkoop">Esther Heijkoop</name><affiliation><nlm:affiliation>Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hermens, Rosella" sort="Hermens, Rosella" uniqKey="Hermens R" first="Rosella" last="Hermens">Rosella Hermens</name><affiliation><nlm:affiliation>Scientific Institute for Quality of Healthcare, Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Humar, Bostjan" sort="Humar, Bostjan" uniqKey="Humar B" first="Bostjan" last="Humar">Bostjan Humar</name><affiliation><nlm:affiliation>Division of Surgical Research, University of Zurich, Zurich, Suisse.</nlm:affiliation></affiliation></author><author><name sortKey="Kaurah, Pardeep" sort="Kaurah, Pardeep" uniqKey="Kaurah P" first="Pardeep" last="Kaurah">Pardeep Kaurah</name><affiliation><nlm:affiliation>Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Keller, Gisella" sort="Keller, Gisella" uniqKey="Keller G" first="Gisella" last="Keller">Gisella Keller</name><affiliation><nlm:affiliation>Institute of Pathology, Technische Universität, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lai, Jennifer" sort="Lai, Jennifer" uniqKey="Lai J" first="Jennifer" last="Lai">Jennifer Lai</name><affiliation><nlm:affiliation>No Stomach For Cancer, Inc., Madison, Wisconsin, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ligtenberg, Marjolijn J L" sort="Ligtenberg, Marjolijn J L" uniqKey="Ligtenberg M" first="Marjolijn J L" last="Ligtenberg">Marjolijn J L. Ligtenberg</name><affiliation><nlm:affiliation>Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="O Donovan, Maria" sort="O Donovan, Maria" uniqKey="O Donovan M" first="Maria" last="O'Donovan">Maria O'Donovan</name><affiliation><nlm:affiliation>Department of Histopathology, Cambridge University Hospitals NHS Trust, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Oliveira, Carla" sort="Oliveira, Carla" uniqKey="Oliveira C" first="Carla" last="Oliveira">Carla Oliveira</name><affiliation><nlm:affiliation>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal Department of Pathology and Oncology, Medical Faculty of the University of Porto, Porto, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Pinheiro, Hugo" sort="Pinheiro, Hugo" uniqKey="Pinheiro H" first="Hugo" last="Pinheiro">Hugo Pinheiro</name><affiliation><nlm:affiliation>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Ragunath, Krish" sort="Ragunath, Krish" uniqKey="Ragunath K" first="Krish" last="Ragunath">Krish Ragunath</name><affiliation><nlm:affiliation>NIHR Biomedical Research Unit, Nottingham Digestive Diseases Centre, Queens Medical Centre campus, Nottingham University Hospitals NHS Trust, Nottingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Rasenberg, Esther" sort="Rasenberg, Esther" uniqKey="Rasenberg E" first="Esther" last="Rasenberg">Esther Rasenberg</name><affiliation><nlm:affiliation>Patient representative, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Richardson, Susan" sort="Richardson, Susan" uniqKey="Richardson S" first="Susan" last="Richardson">Susan Richardson</name><affiliation><nlm:affiliation>Department of Oncology, Familial Gastric Cancer Registry, Cambridge University Hospital, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Roviello, Franco" sort="Roviello, Franco" uniqKey="Roviello F" first="Franco" last="Roviello">Franco Roviello</name><affiliation><nlm:affiliation>Department of General Surgery and Surgical Oncology, University of Siena, Siena, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Schackert, Hans" sort="Schackert, Hans" uniqKey="Schackert H" first="Hans" last="Schackert">Hans Schackert</name><affiliation><nlm:affiliation>Department of Surgical Research, Technical University Dresden, Dresden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Seruca, Raquel" sort="Seruca, Raquel" uniqKey="Seruca R" first="Raquel" last="Seruca">Raquel Seruca</name><affiliation><nlm:affiliation>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal Department of Pathology and Oncology, Medical Faculty of the University of Porto, Porto, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Taylor, Amy" sort="Taylor, Amy" uniqKey="Taylor A" first="Amy" last="Taylor">Amy Taylor</name><affiliation><nlm:affiliation>Cambridge University Hospital, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ter Huurne, Anouk" sort="Ter Huurne, Anouk" uniqKey="Ter Huurne A" first="Anouk" last="Ter Huurne">Anouk Ter Huurne</name><affiliation><nlm:affiliation>Stichting CDH1, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Tischkowitz, Marc" sort="Tischkowitz, Marc" uniqKey="Tischkowitz M" first="Marc" last="Tischkowitz">Marc Tischkowitz</name><affiliation><nlm:affiliation>Department of Medical Genetics, University of Cambridge, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Joe, Sheena Tjon A" sort="Joe, Sheena Tjon A" uniqKey="Joe S" first="Sheena Tjon A" last="Joe">Sheena Tjon A. Joe</name><affiliation><nlm:affiliation>Division of Oncology, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Van Dijck, Benjamin" sort="Van Dijck, Benjamin" uniqKey="Van Dijck B" first="Benjamin" last="Van Dijck">Benjamin Van Dijck</name><affiliation><nlm:affiliation>Stichting CDH1, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van Grieken, Nicole C T" sort="Van Grieken, Nicole C T" uniqKey="Van Grieken N" first="Nicole C T" last="Van Grieken">Nicole C T. Van Grieken</name><affiliation><nlm:affiliation>Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van Hillegersberg, Richard" sort="Van Hillegersberg, Richard" uniqKey="Van Hillegersberg R" first="Richard" last="Van Hillegersberg">Richard Van Hillegersberg</name><affiliation><nlm:affiliation>Department of Surgical Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van Sandick, Johanna W" sort="Van Sandick, Johanna W" uniqKey="Van Sandick J" first="Johanna W" last="Van Sandick">Johanna W. Van Sandick</name><affiliation><nlm:affiliation>Department of Surgery, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Vehof, Rianne" sort="Vehof, Rianne" uniqKey="Vehof R" first="Rianne" last="Vehof">Rianne Vehof</name><affiliation><nlm:affiliation>Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van Krieken, J Han" sort="Van Krieken, J Han" uniqKey="Van Krieken J" first="J Han" last="Van Krieken">J Han Van Krieken</name><affiliation><nlm:affiliation>Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Fitzgerald, Rebecca C" sort="Fitzgerald, Rebecca C" uniqKey="Fitzgerald R" first="Rebecca C" last="Fitzgerald">Rebecca C. Fitzgerald</name><affiliation><nlm:affiliation>Cambridge NIHR Biomedical Research Centre, University of Cambridge NHS Foundation Trust MRC Cancer Unit, Hutchison/MRC Research Centre, Cambridge, UK Department Gastroenterology, Cambridge University Hospitals, UK.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of medical genetics</title><idno type="eISSN">1468-6244</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast Neoplasms (diagnosis)</term><term>Breast Neoplasms (epidemiology)</term><term>Breast Neoplasms (genetics)</term><term>Cadherins (genetics)</term><term>Colorectal Neoplasms (diagnosis)</term><term>Colorectal Neoplasms (epidemiology)</term><term>Colorectal Neoplasms (genetics)</term><term>DNA Mutational Analysis</term><term>Early Detection of Cancer (methods)</term><term>Female</term><term>Genetic Counseling</term><term>Genetic Testing (methods)</term><term>Germ-Line Mutation</term><term>Heterozygote</term><term>Humans</term><term>Population Surveillance</term><term>Practice Guidelines as Topic</term><term>Pregnancy</term><term>Stomach Neoplasms (diagnosis)</term><term>Stomach Neoplasms (epidemiology)</term><term>Stomach Neoplasms (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cadherins</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Breast Neoplasms</term><term>Colorectal Neoplasms</term><term>Stomach Neoplasms</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Breast Neoplasms</term><term>Colorectal Neoplasms</term><term>Stomach Neoplasms</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Breast Neoplasms</term><term>Colorectal Neoplasms</term><term>Stomach Neoplasms</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Early Detection of Cancer</term><term>Genetic Testing</term></keywords><keywords scheme="MESH" xml:lang="en"><term>DNA Mutational Analysis</term><term>Female</term><term>Genetic Counseling</term><term>Germ-Line Mutation</term><term>Heterozygote</term><term>Humans</term><term>Population Surveillance</term><term>Practice Guidelines as Topic</term><term>Pregnancy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic testing, surgery, surveillance strategies, pathology reporting and the patient's perspective on multiple aspects, including diet post gastrectomy. The updated guidelines include revised CDH1 testing criteria (taking into account first-degree and second-degree relatives): (1) families with two or more patients with gastric cancer at any age, one confirmed DGC; (2) individuals with DGC before the age of 40 and (3) families with diagnoses of both DGC and LBC (one diagnosis before the age of 50). Additionally, CDH1 testing could be considered in patients with bilateral or familial LBC before the age of 50, patients with DGC and cleft lip/palate, and those with precursor lesions for signet ring cell carcinoma. Given the high mortality associated with invasive disease, prophylactic total gastrectomy at a centre of expertise is advised for individuals with pathogenic CDH1 mutations. Breast cancer surveillance with annual breast MRI starting at age 30 for women with a CDH1 mutation is recommended. Standardised endoscopic surveillance in experienced centres is recommended for those opting not to have gastrectomy at the current time, those with CDH1 variants of uncertain significance and those that fulfil hereditary DGC criteria without germline CDH1 mutations. Expert histopathological confirmation of (early) signet ring cell carcinoma is recommended. The impact of gastrectomy and mastectomy should not be underestimated; these can have severe consequences on a psychological, physiological and metabolic level. Nutritional problems should be carefully monitored.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25979631</PMID><DateCreated><Year>2015</Year><Month>05</Month><Day>24</Day></DateCreated><DateCompleted><Year>2016</Year><Month>02</Month><Day>24</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-6244</ISSN><JournalIssue CitedMedium="Internet"><Volume>52</Volume><Issue>6</Issue><PubDate><Year>2015</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Journal of medical genetics</Title><ISOAbbreviation>J. Med. Genet.</ISOAbbreviation></Journal><ArticleTitle>Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.</ArticleTitle><Pagination><MedlinePgn>361-74</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/jmedgenet-2015-103094</ELocationID><Abstract><AbstractText>Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic testing, surgery, surveillance strategies, pathology reporting and the patient's perspective on multiple aspects, including diet post gastrectomy. The updated guidelines include revised CDH1 testing criteria (taking into account first-degree and second-degree relatives): (1) families with two or more patients with gastric cancer at any age, one confirmed DGC; (2) individuals with DGC before the age of 40 and (3) families with diagnoses of both DGC and LBC (one diagnosis before the age of 50). Additionally, CDH1 testing could be considered in patients with bilateral or familial LBC before the age of 50, patients with DGC and cleft lip/palate, and those with precursor lesions for signet ring cell carcinoma. Given the high mortality associated with invasive disease, prophylactic total gastrectomy at a centre of expertise is advised for individuals with pathogenic CDH1 mutations. Breast cancer surveillance with annual breast MRI starting at age 30 for women with a CDH1 mutation is recommended. Standardised endoscopic surveillance in experienced centres is recommended for those opting not to have gastrectomy at the current time, those with CDH1 variants of uncertain significance and those that fulfil hereditary DGC criteria without germline CDH1 mutations. Expert histopathological confirmation of (early) signet ring cell carcinoma is recommended. The impact of gastrectomy and mastectomy should not be underestimated; these can have severe consequences on a psychological, physiological and metabolic level. Nutritional problems should be carefully monitored.</AbstractText><CopyrightInformation>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>van der Post</LastName><ForeName>Rachel S</ForeName><Initials>RS</Initials><AffiliationInfo><Affiliation>Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vogelaar</LastName><ForeName>Ingrid P</ForeName><Initials>IP</Initials><AffiliationInfo><Affiliation>Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carneiro</LastName><ForeName>Fátima</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal Department of Pathology and Oncology, Medical Faculty of the University of Porto, Porto, Portugal Centro Hospitalar São João, Porto, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guilford</LastName><ForeName>Parry</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Otago, Dunedin, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huntsman</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>British Columbia Cancer Agency, Vancouver, British Columbia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoogerbrugge</LastName><ForeName>Nicoline</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caldas</LastName><ForeName>Carlos</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Oncology, University of Cambridge, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schreiber</LastName><ForeName>Karen E Chelcun</ForeName><Initials>KE</Initials><AffiliationInfo><Affiliation>No Stomach For Cancer, Inc., Madison, Wisconsin, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hardwick</LastName><ForeName>Richard H</ForeName><Initials>RH</Initials><AffiliationInfo><Affiliation>Department of Oesophago-Gastric Surgery, Addenbrooke's Hospital, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ausems</LastName><ForeName>Margreet G E M</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bardram</LastName><ForeName>Linda</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Surgical Gastroenterology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benusiglio</LastName><ForeName>Patrick R</ForeName><Initials>PR</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bisseling</LastName><ForeName>Tanya M</ForeName><Initials>TM</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology, Radboud University Medical Center, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blair</LastName><ForeName>Vanessa</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Vinery Lane Surgery, Whangarei, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bleiker</LastName><ForeName>Eveline</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Division of Psychosocial Research and Epidemiology/Family Cancer Clinic, The Netherlands Cancer Institute, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boussioutas</LastName><ForeName>Alex</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Sir Peter MacCallum Department of Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cats</LastName><ForeName>Annemieke</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Netherlands Cancer Institute/ Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coit</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>DeGregorio</LastName><ForeName>Lynn</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>The DeGregorio Family Foundation for Stomach and Esophageal Cancer Research, Pleasantville, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Figueiredo</LastName><ForeName>Joana</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ford</LastName><ForeName>James M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Division of Oncology, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heijkoop</LastName><ForeName>Esther</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hermens</LastName><ForeName>Rosella</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Scientific Institute for Quality of Healthcare, Radboud University Medical Center, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Humar</LastName><ForeName>Bostjan</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Division of Surgical Research, University of Zurich, Zurich, Suisse.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaurah</LastName><ForeName>Pardeep</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Keller</LastName><ForeName>Gisella</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institute of Pathology, Technische Universität, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lai</LastName><ForeName>Jennifer</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>No Stomach For Cancer, Inc., Madison, Wisconsin, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ligtenberg</LastName><ForeName>Marjolijn J L</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Donovan</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Histopathology, Cambridge University Hospitals NHS Trust, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oliveira</LastName><ForeName>Carla</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal Department of Pathology and Oncology, Medical Faculty of the University of Porto, Porto, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pinheiro</LastName><ForeName>Hugo</ForeName><Initials>H</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-5329-8224</Identifier><AffiliationInfo><Affiliation>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ragunath</LastName><ForeName>Krish</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>NIHR Biomedical Research Unit, Nottingham Digestive Diseases Centre, Queens Medical Centre campus, Nottingham University Hospitals NHS Trust, Nottingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rasenberg</LastName><ForeName>Esther</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Patient representative, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richardson</LastName><ForeName>Susan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Oncology, Familial Gastric Cancer Registry, Cambridge University Hospital, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roviello</LastName><ForeName>Franco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of General Surgery and Surgical Oncology, University of Siena, Siena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schackert</LastName><ForeName>Hans</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Surgical Research, Technical University Dresden, Dresden, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seruca</LastName><ForeName>Raquel</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal Department of Pathology and Oncology, Medical Faculty of the University of Porto, Porto, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taylor</LastName><ForeName>Amy</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Cambridge University Hospital, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ter Huurne</LastName><ForeName>Anouk</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Stichting CDH1, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tischkowitz</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medical Genetics, University of Cambridge, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Joe</LastName><ForeName>Sheena Tjon A</ForeName><Initials>ST</Initials><AffiliationInfo><Affiliation>Division of Oncology, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Dijck</LastName><ForeName>Benjamin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Stichting CDH1, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Grieken</LastName><ForeName>Nicole C T</ForeName><Initials>NC</Initials><AffiliationInfo><Affiliation>Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Hillegersberg</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Surgical Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Sandick</LastName><ForeName>Johanna W</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>Department of Surgery, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vehof</LastName><ForeName>Rianne</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Radboud University Medical Center, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Krieken</LastName><ForeName>J Han</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fitzgerald</LastName><ForeName>Rebecca C</ForeName><Initials>RC</Initials><AffiliationInfo><Affiliation>Cambridge NIHR Biomedical Research Centre, University of Cambridge NHS Foundation Trust MRC Cancer Unit, Hutchison/MRC Research Centre, Cambridge, UK Department Gastroenterology, Cambridge University Hospitals, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>MC_UU_12022/2</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>05</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Med Genet</MedlineTA><NlmUniqueID>2985087R</NlmUniqueID><ISSNLinking>0022-2593</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C513384">CDH1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015820">Cadherins</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C562840">Breast Cancer, 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MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004252" MajorTopicYN="N">DNA Mutational Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055088" MajorTopicYN="N">Early Detection of Cancer</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005817" MajorTopicYN="N">Genetic Counseling</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005820" MajorTopicYN="N">Genetic Testing</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018095" MajorTopicYN="Y">Germ-Line Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006579" MajorTopicYN="Y">Heterozygote</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011159" MajorTopicYN="N">Population Surveillance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017410" MajorTopicYN="N">Practice Guidelines as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013274" MajorTopicYN="N">Stomach Neoplasms</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4453626</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cancer: breast</Keyword><Keyword MajorTopicYN="N">Cancer: gastric</Keyword><Keyword MajorTopicYN="N">Clinical genetics</Keyword><Keyword MajorTopicYN="N">Diagnostics</Keyword><Keyword MajorTopicYN="N">Stomach and duodenum</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>02</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>03</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>5</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>5</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>2</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25979631</ArticleId><ArticleId IdType="pii">jmedgenet-2015-103094</ArticleId><ArticleId IdType="doi">10.1136/jmedgenet-2015-103094</ArticleId><ArticleId 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HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:25979631" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |